-- dump date 20140619_053618 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1401659000001 HipA N-terminal domain; Region: Couple_hipA; pfam13657 1401659000002 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 1401659000003 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1401659000004 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1401659000005 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1401659000006 salt bridge; other site 1401659000007 non-specific DNA binding site [nucleotide binding]; other site 1401659000008 sequence-specific DNA binding site [nucleotide binding]; other site 1401659000009 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1401659000010 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1401659000011 FAD binding pocket [chemical binding]; other site 1401659000012 FAD binding motif [chemical binding]; other site 1401659000013 phosphate binding motif [ion binding]; other site 1401659000014 NAD binding pocket [chemical binding]; other site 1401659000015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659000016 putative substrate translocation pore; other site 1401659000017 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1401659000018 IucA / IucC family; Region: IucA_IucC; pfam04183 1401659000019 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1401659000020 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1401659000021 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1401659000022 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1401659000023 IucA / IucC family; Region: IucA_IucC; pfam04183 1401659000024 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1401659000025 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 1401659000026 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1401659000027 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1401659000028 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1401659000029 N-terminal plug; other site 1401659000030 ligand-binding site [chemical binding]; other site 1401659000031 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1401659000032 ParB-like nuclease domain; Region: ParB; smart00470 1401659000033 ParB family; Region: ParB; pfam08775 1401659000034 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1401659000035 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1401659000036 P-loop; other site 1401659000037 Magnesium ion binding site [ion binding]; other site 1401659000038 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1401659000039 Magnesium ion binding site [ion binding]; other site 1401659000040 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1401659000041 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1401659000042 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1401659000043 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1401659000044 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1401659000045 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1401659000046 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 1401659000047 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1401659000048 catalytic core [active] 1401659000049 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 1401659000050 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1401659000051 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1401659000052 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1401659000053 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1401659000054 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1401659000055 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659000056 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1401659000057 putative substrate translocation pore; other site 1401659000058 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1401659000059 HTH domain; Region: HTH_11; pfam08279 1401659000060 Predicted transcriptional regulator [Transcription]; Region: COG2378 1401659000061 WYL domain; Region: WYL; pfam13280 1401659000062 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 1401659000063 putative dimer interface [polypeptide binding]; other site 1401659000064 antimicrobial resistance protein Mig-14; Provisional; Region: PRK15312 1401659000065 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 1401659000066 MltA-interacting protein MipA; Region: MipA; cl01504 1401659000067 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1401659000068 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1401659000069 active site 1401659000070 phosphorylation site [posttranslational modification] 1401659000071 intermolecular recognition site; other site 1401659000072 dimerization interface [polypeptide binding]; other site 1401659000073 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1401659000074 DNA binding site [nucleotide binding] 1401659000075 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1401659000076 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1401659000077 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1401659000078 dimer interface [polypeptide binding]; other site 1401659000079 phosphorylation site [posttranslational modification] 1401659000080 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1401659000081 ATP binding site [chemical binding]; other site 1401659000082 Mg2+ binding site [ion binding]; other site 1401659000083 G-X-G motif; other site 1401659000084 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1401659000085 HlyD family secretion protein; Region: HlyD_3; pfam13437 1401659000086 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1401659000087 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1401659000088 nudix motif; other site 1401659000089 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1401659000090 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1401659000091 ABC transporter transmembrane region; Region: ABC_membrane_3; pfam13748 1401659000092 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1401659000093 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1401659000094 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1401659000095 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1401659000096 citrate-proton symporter; Provisional; Region: PRK15075 1401659000097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659000098 putative substrate translocation pore; other site 1401659000099 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1401659000100 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1401659000101 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659000102 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1401659000103 putative dimerization interface [polypeptide binding]; other site 1401659000104 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1401659000105 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1401659000106 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1401659000107 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1401659000108 active site 1401659000109 metal binding site [ion binding]; metal-binding site 1401659000110 hexamer interface [polypeptide binding]; other site 1401659000111 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 1401659000112 Sensors of blue-light using FAD; Region: BLUF; smart01034 1401659000113 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1401659000114 transcriptional regulator MirA; Provisional; Region: PRK15043 1401659000115 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1401659000116 DNA binding residues [nucleotide binding] 1401659000117 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1401659000118 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1401659000119 dimerization interface [polypeptide binding]; other site 1401659000120 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1401659000121 dimer interface [polypeptide binding]; other site 1401659000122 putative CheW interface [polypeptide binding]; other site 1401659000123 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1401659000124 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1401659000125 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1401659000126 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1401659000127 Coenzyme A binding pocket [chemical binding]; other site 1401659000128 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1401659000129 ACT domain-containing protein [General function prediction only]; Region: COG4747 1401659000130 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1401659000131 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1401659000132 dimerization interface [polypeptide binding]; other site 1401659000133 putative DNA binding site [nucleotide binding]; other site 1401659000134 putative Zn2+ binding site [ion binding]; other site 1401659000135 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1401659000136 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1401659000137 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1401659000138 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1401659000139 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1401659000140 active site turn [active] 1401659000141 phosphorylation site [posttranslational modification] 1401659000142 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1401659000143 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1401659000144 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 1401659000145 metal binding site [ion binding]; metal-binding site 1401659000146 substrate binding pocket [chemical binding]; other site 1401659000147 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1401659000148 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1401659000149 DNA-binding site [nucleotide binding]; DNA binding site 1401659000150 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1401659000151 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 1401659000152 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 1401659000153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 1401659000154 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1401659000155 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1401659000156 metal binding site [ion binding]; metal-binding site 1401659000157 active site 1401659000158 I-site; other site 1401659000159 Protein of unknown function (DUF796); Region: DUF796; pfam05638 1401659000160 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1401659000161 ArsC family; Region: ArsC; pfam03960 1401659000162 catalytic residues [active] 1401659000163 arsenical pump membrane protein; Provisional; Region: PRK15445 1401659000164 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1401659000165 transmembrane helices; other site 1401659000166 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1401659000167 putative DNA binding site [nucleotide binding]; other site 1401659000168 putative Zn2+ binding site [ion binding]; other site 1401659000169 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1401659000170 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1401659000171 inhibitor site; inhibition site 1401659000172 active site 1401659000173 dimer interface [polypeptide binding]; other site 1401659000174 catalytic residue [active] 1401659000175 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1401659000176 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1401659000177 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1401659000178 DNA-binding site [nucleotide binding]; DNA binding site 1401659000179 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1401659000180 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659000181 homodimer interface [polypeptide binding]; other site 1401659000182 catalytic residue [active] 1401659000183 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 1401659000184 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1401659000185 dimerization domain [polypeptide binding]; other site 1401659000186 dimer interface [polypeptide binding]; other site 1401659000187 catalytic residues [active] 1401659000188 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 1401659000189 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 1401659000190 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1401659000191 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1401659000192 DsbD alpha interface [polypeptide binding]; other site 1401659000193 catalytic residues [active] 1401659000194 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 1401659000195 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1401659000196 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 1401659000197 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1401659000198 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1401659000199 Walker A/P-loop; other site 1401659000200 ATP binding site [chemical binding]; other site 1401659000201 Q-loop/lid; other site 1401659000202 ABC transporter signature motif; other site 1401659000203 Walker B; other site 1401659000204 D-loop; other site 1401659000205 H-loop/switch region; other site 1401659000206 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1401659000207 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1401659000208 ABC-ATPase subunit interface; other site 1401659000209 dimer interface [polypeptide binding]; other site 1401659000210 putative PBP binding regions; other site 1401659000211 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1401659000212 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1401659000213 intersubunit interface [polypeptide binding]; other site 1401659000214 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1401659000215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659000216 putative substrate translocation pore; other site 1401659000217 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1401659000218 CAT RNA binding domain; Region: CAT_RBD; smart01061 1401659000219 PRD domain; Region: PRD; pfam00874 1401659000220 PRD domain; Region: PRD; pfam00874 1401659000221 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 1401659000222 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1401659000223 active site turn [active] 1401659000224 phosphorylation site [posttranslational modification] 1401659000225 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1401659000226 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 1401659000227 HPr interaction site; other site 1401659000228 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1401659000229 active site 1401659000230 phosphorylation site [posttranslational modification] 1401659000231 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1401659000232 beta-galactosidase; Region: BGL; TIGR03356 1401659000233 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1401659000234 active site 1401659000235 DNA binding site [nucleotide binding] 1401659000236 Int/Topo IB signature motif; other site 1401659000237 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1401659000238 C factor cell-cell signaling protein; Provisional; Region: PRK09009 1401659000239 NAD(P) binding site [chemical binding]; other site 1401659000240 active site 1401659000241 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 1401659000242 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1401659000243 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1401659000244 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1401659000245 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1401659000246 dimer interface [polypeptide binding]; other site 1401659000247 putative CheW interface [polypeptide binding]; other site 1401659000248 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1401659000249 guanine deaminase; Provisional; Region: PRK09228 1401659000250 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 1401659000251 active site 1401659000252 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1401659000253 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1401659000254 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1401659000255 dimer interface [polypeptide binding]; other site 1401659000256 N-terminal domain interface [polypeptide binding]; other site 1401659000257 substrate binding pocket (H-site) [chemical binding]; other site 1401659000258 Cache domain; Region: Cache_1; pfam02743 1401659000259 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1401659000260 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1401659000261 dimer interface [polypeptide binding]; other site 1401659000262 putative CheW interface [polypeptide binding]; other site 1401659000263 AAA ATPase domain; Region: AAA_16; pfam13191 1401659000264 magnesium-transporting ATPase; Provisional; Region: PRK15122 1401659000265 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1401659000266 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1401659000267 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1401659000268 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1401659000269 motif II; other site 1401659000270 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1401659000271 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1401659000272 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 1401659000273 Putative Ig domain; Region: He_PIG; pfam05345 1401659000274 Autotransporter beta-domain; Region: Autotransporter; smart00869 1401659000275 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1401659000276 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1401659000277 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1401659000278 active site 1401659000279 catalytic site [active] 1401659000280 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 1401659000281 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1401659000282 active site 1401659000283 catalytic site [active] 1401659000284 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1401659000285 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1401659000286 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1401659000287 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1401659000288 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1401659000289 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1401659000290 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1401659000291 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1401659000292 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1401659000293 Transposase; Region: HTH_Tnp_1; pfam01527 1401659000294 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1401659000295 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 1401659000296 TraX protein; Region: TraX; pfam05857 1401659000297 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1401659000298 oligomeric interface; other site 1401659000299 putative active site [active] 1401659000300 homodimer interface [polypeptide binding]; other site 1401659000301 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 1401659000302 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 1401659000303 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 1401659000304 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1401659000305 dimerization interface [polypeptide binding]; other site 1401659000306 putative DNA binding site [nucleotide binding]; other site 1401659000307 putative Zn2+ binding site [ion binding]; other site 1401659000308 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 1401659000309 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 1401659000310 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1401659000311 P loop; other site 1401659000312 Nucleotide binding site [chemical binding]; other site 1401659000313 DTAP/Switch II; other site 1401659000314 Switch I; other site 1401659000315 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1401659000316 P loop; other site 1401659000317 Nucleotide binding site [chemical binding]; other site 1401659000318 DTAP/Switch II; other site 1401659000319 Switch I; other site 1401659000320 arsenical pump membrane protein; Provisional; Region: PRK15445 1401659000321 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1401659000322 transmembrane helices; other site 1401659000323 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1401659000324 ArsC family; Region: ArsC; pfam03960 1401659000325 catalytic residues [active] 1401659000326 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1401659000327 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1401659000328 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1401659000329 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1401659000330 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1401659000331 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1401659000332 Coenzyme A binding pocket [chemical binding]; other site 1401659000333 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 1401659000334 amphipathic channel; other site 1401659000335 Asn-Pro-Ala signature motifs; other site 1401659000336 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1401659000337 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1401659000338 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1401659000339 dimerization interface [polypeptide binding]; other site 1401659000340 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1401659000341 dimer interface [polypeptide binding]; other site 1401659000342 phosphorylation site [posttranslational modification] 1401659000343 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1401659000344 ATP binding site [chemical binding]; other site 1401659000345 Mg2+ binding site [ion binding]; other site 1401659000346 G-X-G motif; other site 1401659000347 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1401659000348 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1401659000349 active site 1401659000350 phosphorylation site [posttranslational modification] 1401659000351 intermolecular recognition site; other site 1401659000352 dimerization interface [polypeptide binding]; other site 1401659000353 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1401659000354 DNA binding site [nucleotide binding] 1401659000355 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1401659000356 CopC domain; Region: CopC; pfam04234 1401659000357 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 1401659000358 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 1401659000359 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1401659000360 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1401659000361 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1401659000362 Peptidase family M23; Region: Peptidase_M23; pfam01551 1401659000363 Protein of unknown function (DUF2933); Region: DUF2933; pfam11666 1401659000364 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1401659000365 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1401659000366 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1401659000367 motif II; other site 1401659000368 Protein of unknown function, DUF; Region: DUF411; cl01142 1401659000369 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 1401659000370 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 1401659000371 HlyD family secretion protein; Region: HlyD_3; pfam13437 1401659000372 periplasmic copper-binding protein; Provisional; Region: PRK09838 1401659000373 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 1401659000374 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 1401659000375 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1401659000376 active site 1401659000377 phosphorylation site [posttranslational modification] 1401659000378 intermolecular recognition site; other site 1401659000379 dimerization interface [polypeptide binding]; other site 1401659000380 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1401659000381 DNA binding site [nucleotide binding] 1401659000382 sensor kinase CusS; Provisional; Region: PRK09835 1401659000383 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1401659000384 dimerization interface [polypeptide binding]; other site 1401659000385 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1401659000386 dimer interface [polypeptide binding]; other site 1401659000387 phosphorylation site [posttranslational modification] 1401659000388 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1401659000389 ATP binding site [chemical binding]; other site 1401659000390 Mg2+ binding site [ion binding]; other site 1401659000391 G-X-G motif; other site 1401659000392 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1401659000393 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 1401659000394 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1401659000395 active site 1401659000396 Phage integrase family; Region: Phage_integrase; pfam00589 1401659000397 active site 1401659000398 DNA binding site [nucleotide binding] 1401659000399 Int/Topo IB signature motif; other site 1401659000400 ParG; Region: ParG; pfam09274 1401659000401 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1401659000402 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1401659000403 P-loop; other site 1401659000404 Magnesium ion binding site [ion binding]; other site 1401659000405 modulator of post-segregation killing protein; Provisional; Region: PRK13720 1401659000406 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1401659000407 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1401659000408 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 1401659000409 IncFII RepA protein family; Region: IncFII_repA; cl11495 1401659000410 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 1401659000411 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1401659000412 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1401659000413 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1401659000414 Walker A motif; other site 1401659000415 ATP binding site [chemical binding]; other site 1401659000416 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1401659000417 Walker B motif; other site 1401659000418 arginine finger; other site 1401659000419 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1401659000420 DnaA box-binding interface [nucleotide binding]; other site 1401659000421 DNA polymerase III subunit beta; Validated; Region: PRK05643 1401659000422 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1401659000423 putative DNA binding surface [nucleotide binding]; other site 1401659000424 dimer interface [polypeptide binding]; other site 1401659000425 beta-clamp/clamp loader binding surface; other site 1401659000426 beta-clamp/translesion DNA polymerase binding surface; other site 1401659000427 recF protein; Region: recf; TIGR00611 1401659000428 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1401659000429 Walker A/P-loop; other site 1401659000430 ATP binding site [chemical binding]; other site 1401659000431 Q-loop/lid; other site 1401659000432 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1401659000433 ABC transporter signature motif; other site 1401659000434 Walker B; other site 1401659000435 D-loop; other site 1401659000436 H-loop/switch region; other site 1401659000437 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1401659000438 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1401659000439 Mg2+ binding site [ion binding]; other site 1401659000440 G-X-G motif; other site 1401659000441 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1401659000442 anchoring element; other site 1401659000443 dimer interface [polypeptide binding]; other site 1401659000444 ATP binding site [chemical binding]; other site 1401659000445 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1401659000446 active site 1401659000447 putative metal-binding site [ion binding]; other site 1401659000448 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1401659000449 sugar phosphate phosphatase; Provisional; Region: PRK10513 1401659000450 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1401659000451 active site 1401659000452 motif I; other site 1401659000453 motif II; other site 1401659000454 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1401659000455 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1401659000456 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1401659000457 DNA-binding site [nucleotide binding]; DNA binding site 1401659000458 FCD domain; Region: FCD; pfam07729 1401659000459 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 1401659000460 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 1401659000461 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 1401659000462 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1401659000463 active site 1401659000464 intersubunit interface [polypeptide binding]; other site 1401659000465 catalytic residue [active] 1401659000466 galactonate dehydratase; Provisional; Region: PRK14017 1401659000467 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 1401659000468 putative active site pocket [active] 1401659000469 putative metal binding site [ion binding]; other site 1401659000470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659000471 D-galactonate transporter; Region: 2A0114; TIGR00893 1401659000472 putative substrate translocation pore; other site 1401659000473 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1401659000474 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659000475 putative substrate translocation pore; other site 1401659000476 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1401659000477 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 1401659000478 putative ligand binding site [chemical binding]; other site 1401659000479 NAD binding site [chemical binding]; other site 1401659000480 catalytic site [active] 1401659000481 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 1401659000482 hypothetical protein; Provisional; Region: PRK11616 1401659000483 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1401659000484 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1401659000485 putative dimer interface [polypeptide binding]; other site 1401659000486 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1401659000487 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1401659000488 putative dimer interface [polypeptide binding]; other site 1401659000489 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1401659000490 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1401659000491 DNA-binding site [nucleotide binding]; DNA binding site 1401659000492 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1401659000493 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1401659000494 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1401659000495 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1401659000496 active site turn [active] 1401659000497 phosphorylation site [posttranslational modification] 1401659000498 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1401659000499 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 1401659000500 NAD binding site [chemical binding]; other site 1401659000501 sugar binding site [chemical binding]; other site 1401659000502 divalent metal binding site [ion binding]; other site 1401659000503 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1401659000504 dimer interface [polypeptide binding]; other site 1401659000505 Predicted membrane protein [Function unknown]; Region: COG2149 1401659000506 Domain of unknown function (DUF202); Region: DUF202; pfam02656 1401659000507 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 1401659000508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659000509 putative substrate translocation pore; other site 1401659000510 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1401659000511 Coenzyme A binding pocket [chemical binding]; other site 1401659000512 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 1401659000513 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 1401659000514 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1401659000515 hypothetical protein; Provisional; Region: PRK07033 1401659000516 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 1401659000517 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1401659000518 ligand binding site [chemical binding]; other site 1401659000519 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 1401659000520 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1401659000521 G1 box; other site 1401659000522 GTP/Mg2+ binding site [chemical binding]; other site 1401659000523 G2 box; other site 1401659000524 Switch I region; other site 1401659000525 G3 box; other site 1401659000526 Switch II region; other site 1401659000527 G4 box; other site 1401659000528 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1401659000529 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1401659000530 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 1401659000531 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 1401659000532 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1401659000533 Protein of unknown function (DUF770); Region: DUF770; pfam05591 1401659000534 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 1401659000535 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1401659000536 Protein of unknown function (DUF796); Region: DUF796; pfam05638 1401659000537 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1401659000538 phosphopeptide binding site; other site 1401659000539 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1401659000540 active site 1401659000541 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 1401659000542 ImpE protein; Region: ImpE; pfam07024 1401659000543 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1401659000544 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1401659000545 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1401659000546 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 1401659000547 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1401659000548 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1401659000549 Walker A motif; other site 1401659000550 ATP binding site [chemical binding]; other site 1401659000551 Walker B motif; other site 1401659000552 arginine finger; other site 1401659000553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1401659000554 Walker A motif; other site 1401659000555 ATP binding site [chemical binding]; other site 1401659000556 Walker B motif; other site 1401659000557 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1401659000558 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1401659000559 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1401659000560 active site 1401659000561 ATP binding site [chemical binding]; other site 1401659000562 substrate binding site [chemical binding]; other site 1401659000563 activation loop (A-loop); other site 1401659000564 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1401659000565 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1401659000566 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1401659000567 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1401659000568 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1401659000569 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 1401659000570 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1401659000571 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1401659000572 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1401659000573 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1401659000574 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1401659000575 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1401659000576 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1401659000577 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1401659000578 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1401659000579 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1401659000580 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1401659000581 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1401659000582 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 1401659000583 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 1401659000584 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1401659000585 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1401659000586 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1401659000587 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 1401659000588 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 1401659000589 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 1401659000590 PAAR motif; Region: PAAR_motif; pfam05488 1401659000591 RHS Repeat; Region: RHS_repeat; cl11982 1401659000592 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1401659000593 RHS Repeat; Region: RHS_repeat; cl11982 1401659000594 RHS Repeat; Region: RHS_repeat; pfam05593 1401659000595 RHS Repeat; Region: RHS_repeat; pfam05593 1401659000596 RHS Repeat; Region: RHS_repeat; pfam05593 1401659000597 RHS Repeat; Region: RHS_repeat; cl11982 1401659000598 RHS Repeat; Region: RHS_repeat; cl11982 1401659000599 RHS Repeat; Region: RHS_repeat; cl11982 1401659000600 RHS protein; Region: RHS; pfam03527 1401659000601 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1401659000602 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1401659000603 RHS protein; Region: RHS; pfam03527 1401659000604 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1401659000605 RHS protein; Region: RHS; pfam03527 1401659000606 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1401659000607 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1401659000608 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1401659000609 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1401659000610 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1401659000611 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 1401659000612 PAAR motif; Region: PAAR_motif; pfam05488 1401659000613 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1401659000614 RHS Repeat; Region: RHS_repeat; pfam05593 1401659000615 RHS Repeat; Region: RHS_repeat; pfam05593 1401659000616 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1401659000617 RHS Repeat; Region: RHS_repeat; pfam05593 1401659000618 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1401659000619 RHS protein; Region: RHS; pfam03527 1401659000620 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1401659000621 A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414 1401659000622 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1401659000623 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1401659000624 RHS Repeat; Region: RHS_repeat; pfam05593 1401659000625 RHS Repeat; Region: RHS_repeat; cl11982 1401659000626 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1401659000627 RHS Repeat; Region: RHS_repeat; pfam05593 1401659000628 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1401659000629 RHS protein; Region: RHS; pfam03527 1401659000630 RHS Repeat; Region: RHS_repeat; cl11982 1401659000631 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1401659000632 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 1401659000633 triosephosphate isomerase; Provisional; Region: PRK14567 1401659000634 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1401659000635 substrate binding site [chemical binding]; other site 1401659000636 dimer interface [polypeptide binding]; other site 1401659000637 catalytic triad [active] 1401659000638 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 1401659000639 Predicted membrane protein [Function unknown]; Region: COG3152 1401659000640 ferredoxin-NADP reductase; Provisional; Region: PRK10926 1401659000641 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1401659000642 FAD binding pocket [chemical binding]; other site 1401659000643 FAD binding motif [chemical binding]; other site 1401659000644 phosphate binding motif [ion binding]; other site 1401659000645 beta-alpha-beta structure motif; other site 1401659000646 NAD binding pocket [chemical binding]; other site 1401659000647 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1401659000648 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1401659000649 putative active site [active] 1401659000650 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 1401659000651 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 1401659000652 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1401659000653 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1401659000654 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1401659000655 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 1401659000656 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1401659000657 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1401659000658 active site 1401659000659 P-loop; other site 1401659000660 phosphorylation site [posttranslational modification] 1401659000661 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1401659000662 active site 1401659000663 phosphorylation site [posttranslational modification] 1401659000664 putative glutathione S-transferase; Provisional; Region: PRK10357 1401659000665 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 1401659000666 putative C-terminal domain interface [polypeptide binding]; other site 1401659000667 putative GSH binding site (G-site) [chemical binding]; other site 1401659000668 putative dimer interface [polypeptide binding]; other site 1401659000669 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1401659000670 dimer interface [polypeptide binding]; other site 1401659000671 N-terminal domain interface [polypeptide binding]; other site 1401659000672 putative substrate binding pocket (H-site) [chemical binding]; other site 1401659000673 selenocysteine synthase; Provisional; Region: PRK04311 1401659000674 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 1401659000675 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 1401659000676 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 1401659000677 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1401659000678 G1 box; other site 1401659000679 putative GEF interaction site [polypeptide binding]; other site 1401659000680 GTP/Mg2+ binding site [chemical binding]; other site 1401659000681 Switch I region; other site 1401659000682 G2 box; other site 1401659000683 G3 box; other site 1401659000684 Switch II region; other site 1401659000685 G4 box; other site 1401659000686 G5 box; other site 1401659000687 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1401659000688 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 1401659000689 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 1401659000690 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1401659000691 putative alcohol dehydrogenase; Provisional; Region: PRK09860 1401659000692 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1401659000693 dimer interface [polypeptide binding]; other site 1401659000694 active site 1401659000695 metal binding site [ion binding]; metal-binding site 1401659000696 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1401659000697 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1401659000698 nucleotide binding site [chemical binding]; other site 1401659000699 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1401659000700 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1401659000701 non-specific DNA binding site [nucleotide binding]; other site 1401659000702 salt bridge; other site 1401659000703 sequence-specific DNA binding site [nucleotide binding]; other site 1401659000704 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 1401659000705 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1401659000706 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 1401659000707 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1401659000708 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1401659000709 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1401659000710 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1401659000711 molybdopterin cofactor binding site; other site 1401659000712 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1401659000713 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1401659000714 molybdopterin cofactor binding site; other site 1401659000715 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1401659000716 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1401659000717 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 1401659000718 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1401659000719 AzlC protein; Region: AzlC; cl00570 1401659000720 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1401659000721 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1401659000722 non-specific DNA binding site [nucleotide binding]; other site 1401659000723 salt bridge; other site 1401659000724 sequence-specific DNA binding site [nucleotide binding]; other site 1401659000725 Cupin domain; Region: Cupin_2; cl17218 1401659000726 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1401659000727 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1401659000728 DNA binding site [nucleotide binding] 1401659000729 domain linker motif; other site 1401659000730 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 1401659000731 ligand binding site [chemical binding]; other site 1401659000732 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1401659000733 Melibiase; Region: Melibiase; pfam02065 1401659000734 galactoside permease; Reviewed; Region: lacY; PRK09528 1401659000735 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659000736 putative substrate translocation pore; other site 1401659000737 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 1401659000738 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1401659000739 intersubunit interface [polypeptide binding]; other site 1401659000740 active site 1401659000741 Zn2+ binding site [ion binding]; other site 1401659000742 L-rhamnose isomerase; Provisional; Region: PRK01076 1401659000743 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1401659000744 N- and C-terminal domain interface [polypeptide binding]; other site 1401659000745 active site 1401659000746 putative catalytic site [active] 1401659000747 metal binding site [ion binding]; metal-binding site 1401659000748 ATP binding site [chemical binding]; other site 1401659000749 rhamnulokinase; Provisional; Region: rhaB; PRK10640 1401659000750 carbohydrate binding site [chemical binding]; other site 1401659000751 transcriptional activator RhaS; Provisional; Region: PRK13503 1401659000752 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1401659000753 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1401659000754 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1401659000755 transcriptional activator RhaR; Provisional; Region: PRK13501 1401659000756 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1401659000757 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1401659000758 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 1401659000759 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 1401659000760 superoxide dismutase; Provisional; Region: PRK10925 1401659000761 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1401659000762 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1401659000763 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 1401659000764 MOSC domain; Region: MOSC; pfam03473 1401659000765 3-alpha domain; Region: 3-alpha; pfam03475 1401659000766 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 1401659000767 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1401659000768 active site 1401659000769 substrate binding site [chemical binding]; other site 1401659000770 FMN binding site [chemical binding]; other site 1401659000771 putative catalytic residues [active] 1401659000772 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 1401659000773 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1401659000774 DNA-binding site [nucleotide binding]; DNA binding site 1401659000775 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1401659000776 L-lactate permease; Provisional; Region: PRK10420 1401659000777 glycolate transporter; Provisional; Region: PRK09695 1401659000778 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 1401659000779 hypothetical protein; Provisional; Region: PRK11020 1401659000780 glycerol kinase; Provisional; Region: glpK; PRK00047 1401659000781 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1401659000782 N- and C-terminal domain interface [polypeptide binding]; other site 1401659000783 active site 1401659000784 MgATP binding site [chemical binding]; other site 1401659000785 catalytic site [active] 1401659000786 metal binding site [ion binding]; metal-binding site 1401659000787 glycerol binding site [chemical binding]; other site 1401659000788 homotetramer interface [polypeptide binding]; other site 1401659000789 homodimer interface [polypeptide binding]; other site 1401659000790 FBP binding site [chemical binding]; other site 1401659000791 protein IIAGlc interface [polypeptide binding]; other site 1401659000792 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1401659000793 amphipathic channel; other site 1401659000794 Asn-Pro-Ala signature motifs; other site 1401659000795 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3074 1401659000796 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1401659000797 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1401659000798 UbiA prenyltransferase family; Region: UbiA; pfam01040 1401659000799 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1401659000800 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1401659000801 Walker A motif; other site 1401659000802 ATP binding site [chemical binding]; other site 1401659000803 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1401659000804 Walker B motif; other site 1401659000805 arginine finger; other site 1401659000806 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1401659000807 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1401659000808 active site 1401659000809 HslU subunit interaction site [polypeptide binding]; other site 1401659000810 Sporulation related domain; Region: SPOR; cl10051 1401659000811 cell division protein FtsN; Provisional; Region: PRK12757 1401659000812 Sporulation related domain; Region: SPOR; cl10051 1401659000813 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1401659000814 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 1401659000815 DNA binding site [nucleotide binding] 1401659000816 domain linker motif; other site 1401659000817 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 1401659000818 dimerization interface [polypeptide binding]; other site 1401659000819 ligand binding site [chemical binding]; other site 1401659000820 primosome assembly protein PriA; Validated; Region: PRK05580 1401659000821 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1401659000822 ATP binding site [chemical binding]; other site 1401659000823 putative Mg++ binding site [ion binding]; other site 1401659000824 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1401659000825 ATP-binding site [chemical binding]; other site 1401659000826 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1401659000827 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 1401659000828 dimerization interface [polypeptide binding]; other site 1401659000829 DNA binding site [nucleotide binding] 1401659000830 corepressor binding sites; other site 1401659000831 cystathionine gamma-synthase; Provisional; Region: PRK08045 1401659000832 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1401659000833 homodimer interface [polypeptide binding]; other site 1401659000834 substrate-cofactor binding pocket; other site 1401659000835 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659000836 catalytic residue [active] 1401659000837 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 1401659000838 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1401659000839 putative catalytic residues [active] 1401659000840 putative nucleotide binding site [chemical binding]; other site 1401659000841 putative aspartate binding site [chemical binding]; other site 1401659000842 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1401659000843 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1401659000844 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1401659000845 FAD binding site [chemical binding]; other site 1401659000846 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1401659000847 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1401659000848 putative active site [active] 1401659000849 heme pocket [chemical binding]; other site 1401659000850 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1401659000851 putative active site [active] 1401659000852 heme pocket [chemical binding]; other site 1401659000853 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1401659000854 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1401659000855 dimer interface [polypeptide binding]; other site 1401659000856 putative CheW interface [polypeptide binding]; other site 1401659000857 malate:quinone oxidoreductase; Validated; Region: PRK05257 1401659000858 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1401659000859 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1401659000860 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1401659000861 dimerization interface [polypeptide binding]; other site 1401659000862 ligand binding site [chemical binding]; other site 1401659000863 NADP binding site [chemical binding]; other site 1401659000864 catalytic site [active] 1401659000865 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659000866 D-galactonate transporter; Region: 2A0114; TIGR00893 1401659000867 putative substrate translocation pore; other site 1401659000868 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1401659000869 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1401659000870 substrate binding site [chemical binding]; other site 1401659000871 ATP binding site [chemical binding]; other site 1401659000872 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1401659000873 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1401659000874 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1401659000875 DNA binding site [nucleotide binding] 1401659000876 domain linker motif; other site 1401659000877 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1401659000878 putative dimerization interface [polypeptide binding]; other site 1401659000879 putative ligand binding site [chemical binding]; other site 1401659000880 zinc/cadmium-binding protein; Provisional; Region: PRK10306 1401659000881 putative outer membrane lipoprotein; Provisional; Region: PRK10510 1401659000882 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1401659000883 ligand binding site [chemical binding]; other site 1401659000884 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1401659000885 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1401659000886 molybdopterin cofactor binding site [chemical binding]; other site 1401659000887 substrate binding site [chemical binding]; other site 1401659000888 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1401659000889 molybdopterin cofactor binding site; other site 1401659000890 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1401659000891 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1401659000892 Coenzyme A binding pocket [chemical binding]; other site 1401659000893 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1401659000894 Autotransporter beta-domain; Region: Autotransporter; cl17461 1401659000895 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1401659000896 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659000897 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1401659000898 phosphoethanolamine transferase; Provisional; Region: PRK11560 1401659000899 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1401659000900 Sulfatase; Region: Sulfatase; pfam00884 1401659000901 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1401659000902 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1401659000903 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1401659000904 peptide binding site [polypeptide binding]; other site 1401659000905 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1401659000906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659000907 dimer interface [polypeptide binding]; other site 1401659000908 conserved gate region; other site 1401659000909 putative PBP binding loops; other site 1401659000910 ABC-ATPase subunit interface; other site 1401659000911 dipeptide transporter; Provisional; Region: PRK10913 1401659000912 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1401659000913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659000914 dimer interface [polypeptide binding]; other site 1401659000915 conserved gate region; other site 1401659000916 putative PBP binding loops; other site 1401659000917 ABC-ATPase subunit interface; other site 1401659000918 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 1401659000919 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1401659000920 Walker A/P-loop; other site 1401659000921 ATP binding site [chemical binding]; other site 1401659000922 Q-loop/lid; other site 1401659000923 ABC transporter signature motif; other site 1401659000924 Walker B; other site 1401659000925 D-loop; other site 1401659000926 H-loop/switch region; other site 1401659000927 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1401659000928 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1401659000929 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1401659000930 Walker A/P-loop; other site 1401659000931 ATP binding site [chemical binding]; other site 1401659000932 Q-loop/lid; other site 1401659000933 ABC transporter signature motif; other site 1401659000934 Walker B; other site 1401659000935 D-loop; other site 1401659000936 H-loop/switch region; other site 1401659000937 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1401659000938 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 1401659000939 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 1401659000940 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 1401659000941 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 1401659000942 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 1401659000943 YhjQ protein; Region: YhjQ; pfam06564 1401659000944 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1401659000945 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 1401659000946 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1401659000947 DXD motif; other site 1401659000948 PilZ domain; Region: PilZ; pfam07238 1401659000949 cellulose synthase regulator protein; Provisional; Region: PRK11114 1401659000950 endo-1,4-D-glucanase; Provisional; Region: PRK11097 1401659000951 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 1401659000952 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1401659000953 TPR motif; other site 1401659000954 binding surface 1401659000955 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 1401659000956 putative diguanylate cyclase; Provisional; Region: PRK13561 1401659000957 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1401659000958 dimerization interface [polypeptide binding]; other site 1401659000959 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1401659000960 I-site; other site 1401659000961 active site 1401659000962 metal binding site [ion binding]; metal-binding site 1401659000963 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1401659000964 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1401659000965 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1401659000966 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1401659000967 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1401659000968 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1401659000969 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1401659000970 substrate binding site [chemical binding]; other site 1401659000971 ATP binding site [chemical binding]; other site 1401659000972 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1401659000973 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1401659000974 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1401659000975 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659000976 metabolite-proton symporter; Region: 2A0106; TIGR00883 1401659000977 putative substrate translocation pore; other site 1401659000978 inner membrane protein YhjD; Region: TIGR00766 1401659000979 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1401659000980 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659000981 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1401659000982 putative effector binding pocket; other site 1401659000983 putative dimerization interface [polypeptide binding]; other site 1401659000984 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1401659000985 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1401659000986 NAD(P) binding site [chemical binding]; other site 1401659000987 active site 1401659000988 hypothetical protein; Provisional; Region: PRK10053 1401659000989 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1401659000990 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1401659000991 glutathione reductase; Validated; Region: PRK06116 1401659000992 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1401659000993 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1401659000994 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1401659000995 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1401659000996 oligopeptidase A; Provisional; Region: PRK10911 1401659000997 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1401659000998 active site 1401659000999 Zn binding site [ion binding]; other site 1401659001000 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1401659001001 S-adenosylmethionine binding site [chemical binding]; other site 1401659001002 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1401659001003 Ligand Binding Site [chemical binding]; other site 1401659001004 universal stress protein UspB; Provisional; Region: PRK04960 1401659001005 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1401659001006 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1401659001007 Predicted flavoproteins [General function prediction only]; Region: COG2081 1401659001008 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1401659001009 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1401659001010 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1401659001011 active site 1401659001012 homotetramer interface [polypeptide binding]; other site 1401659001013 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1401659001014 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1401659001015 NlpC/P60 family; Region: NLPC_P60; pfam00877 1401659001016 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1401659001017 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1401659001018 major facilitator superfamily transporter; Provisional; Region: PRK05122 1401659001019 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659001020 putative substrate translocation pore; other site 1401659001021 hypothetical protein; Provisional; Region: PRK11615 1401659001022 hypothetical protein; Provisional; Region: PRK11212 1401659001023 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 1401659001024 CPxP motif; other site 1401659001025 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1401659001026 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1401659001027 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1401659001028 DctM-like transporters; Region: DctM; pfam06808 1401659001029 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1401659001030 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 1401659001031 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1401659001032 metal-binding site [ion binding] 1401659001033 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1401659001034 Predicted membrane protein [Function unknown]; Region: COG3714 1401659001035 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 1401659001036 hypothetical protein; Provisional; Region: PRK10910 1401659001037 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1401659001038 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1401659001039 S-adenosylmethionine binding site [chemical binding]; other site 1401659001040 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1401659001041 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1401659001042 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1401659001043 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1401659001044 P loop; other site 1401659001045 GTP binding site [chemical binding]; other site 1401659001046 cell division protein FtsE; Provisional; Region: PRK10908 1401659001047 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1401659001048 Walker A/P-loop; other site 1401659001049 ATP binding site [chemical binding]; other site 1401659001050 Q-loop/lid; other site 1401659001051 ABC transporter signature motif; other site 1401659001052 Walker B; other site 1401659001053 D-loop; other site 1401659001054 H-loop/switch region; other site 1401659001055 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1401659001056 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 1401659001057 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1401659001058 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1401659001059 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1401659001060 DNA binding residues [nucleotide binding] 1401659001061 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1401659001062 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1401659001063 DNA-binding site [nucleotide binding]; DNA binding site 1401659001064 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1401659001065 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659001066 homodimer interface [polypeptide binding]; other site 1401659001067 catalytic residue [active] 1401659001068 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 1401659001069 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1401659001070 inhibitor-cofactor binding pocket; inhibition site 1401659001071 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659001072 catalytic residue [active] 1401659001073 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1401659001074 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1401659001075 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1401659001076 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1401659001077 dimerization interface [polypeptide binding]; other site 1401659001078 ligand binding site [chemical binding]; other site 1401659001079 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 1401659001080 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1401659001081 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1401659001082 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1401659001083 TM-ABC transporter signature motif; other site 1401659001084 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1401659001085 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1401659001086 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1401659001087 TM-ABC transporter signature motif; other site 1401659001088 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1401659001089 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1401659001090 Walker A/P-loop; other site 1401659001091 ATP binding site [chemical binding]; other site 1401659001092 Q-loop/lid; other site 1401659001093 ABC transporter signature motif; other site 1401659001094 Walker B; other site 1401659001095 D-loop; other site 1401659001096 H-loop/switch region; other site 1401659001097 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 1401659001098 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1401659001099 Walker A/P-loop; other site 1401659001100 ATP binding site [chemical binding]; other site 1401659001101 Q-loop/lid; other site 1401659001102 ABC transporter signature motif; other site 1401659001103 Walker B; other site 1401659001104 D-loop; other site 1401659001105 H-loop/switch region; other site 1401659001106 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 1401659001107 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1401659001108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659001109 dimer interface [polypeptide binding]; other site 1401659001110 conserved gate region; other site 1401659001111 putative PBP binding loops; other site 1401659001112 ABC-ATPase subunit interface; other site 1401659001113 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1401659001114 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659001115 dimer interface [polypeptide binding]; other site 1401659001116 conserved gate region; other site 1401659001117 putative PBP binding loops; other site 1401659001118 ABC-ATPase subunit interface; other site 1401659001119 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1401659001120 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1401659001121 Walker A/P-loop; other site 1401659001122 ATP binding site [chemical binding]; other site 1401659001123 Q-loop/lid; other site 1401659001124 ABC transporter signature motif; other site 1401659001125 Walker B; other site 1401659001126 D-loop; other site 1401659001127 H-loop/switch region; other site 1401659001128 TOBE domain; Region: TOBE_2; pfam08402 1401659001129 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 1401659001130 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1401659001131 putative active site [active] 1401659001132 catalytic site [active] 1401659001133 putative metal binding site [ion binding]; other site 1401659001134 hypothetical protein; Provisional; Region: PRK10350 1401659001135 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 1401659001136 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1401659001137 putative acetyltransferase YhhY; Provisional; Region: PRK10140 1401659001138 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1401659001139 Coenzyme A binding pocket [chemical binding]; other site 1401659001140 putative oxidoreductase; Provisional; Region: PRK10206 1401659001141 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1401659001142 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1401659001143 Pirin-related protein [General function prediction only]; Region: COG1741 1401659001144 Pirin; Region: Pirin; pfam02678 1401659001145 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 1401659001146 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1401659001147 DNA binding site [nucleotide binding] 1401659001148 domain linker motif; other site 1401659001149 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1401659001150 putative ligand binding site [chemical binding]; other site 1401659001151 putative dimerization interface [polypeptide binding]; other site 1401659001152 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1401659001153 ATP-binding site [chemical binding]; other site 1401659001154 Gluconate-6-phosphate binding site [chemical binding]; other site 1401659001155 low affinity gluconate transporter; Provisional; Region: PRK10472 1401659001156 gluconate transporter; Region: gntP; TIGR00791 1401659001157 putative antibiotic transporter; Provisional; Region: PRK10739 1401659001158 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1401659001159 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1401659001160 glycogen branching enzyme; Provisional; Region: PRK05402 1401659001161 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1401659001162 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1401659001163 active site 1401659001164 catalytic site [active] 1401659001165 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1401659001166 glycogen debranching enzyme; Provisional; Region: PRK03705 1401659001167 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1401659001168 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1401659001169 active site 1401659001170 catalytic site [active] 1401659001171 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 1401659001172 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1401659001173 ligand binding site; other site 1401659001174 oligomer interface; other site 1401659001175 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1401659001176 dimer interface [polypeptide binding]; other site 1401659001177 N-terminal domain interface [polypeptide binding]; other site 1401659001178 sulfate 1 binding site; other site 1401659001179 glycogen synthase; Provisional; Region: glgA; PRK00654 1401659001180 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1401659001181 ADP-binding pocket [chemical binding]; other site 1401659001182 homodimer interface [polypeptide binding]; other site 1401659001183 glycogen phosphorylase; Provisional; Region: PRK14986 1401659001184 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1401659001185 homodimer interface [polypeptide binding]; other site 1401659001186 active site pocket [active] 1401659001187 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1401659001188 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1401659001189 metal binding site [ion binding]; metal-binding site 1401659001190 active site 1401659001191 I-site; other site 1401659001192 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1401659001193 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1401659001194 active site residue [active] 1401659001195 intramembrane serine protease GlpG; Provisional; Region: PRK10907 1401659001196 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 1401659001197 Rhomboid family; Region: Rhomboid; cl11446 1401659001198 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 1401659001199 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1401659001200 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1401659001201 transcriptional regulator MalT; Provisional; Region: PRK04841 1401659001202 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1401659001203 DNA binding residues [nucleotide binding] 1401659001204 dimerization interface [polypeptide binding]; other site 1401659001205 maltodextrin phosphorylase; Provisional; Region: PRK14985 1401659001206 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1401659001207 active site pocket [active] 1401659001208 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1401659001209 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1401659001210 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1401659001211 DNA-binding site [nucleotide binding]; DNA binding site 1401659001212 RNA-binding motif; other site 1401659001213 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 1401659001214 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1401659001215 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1401659001216 DNA utilization protein GntX; Provisional; Region: PRK11595 1401659001217 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1401659001218 active site 1401659001219 carboxylesterase BioH; Provisional; Region: PRK10349 1401659001220 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1401659001221 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1401659001222 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 1401659001223 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 1401659001224 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1401659001225 G1 box; other site 1401659001226 GTP/Mg2+ binding site [chemical binding]; other site 1401659001227 Switch I region; other site 1401659001228 G2 box; other site 1401659001229 G3 box; other site 1401659001230 Switch II region; other site 1401659001231 G4 box; other site 1401659001232 G5 box; other site 1401659001233 Nucleoside recognition; Region: Gate; pfam07670 1401659001234 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1401659001235 Nucleoside recognition; Region: Gate; pfam07670 1401659001236 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 1401659001237 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1401659001238 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1401659001239 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1401659001240 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1401659001241 RNA binding site [nucleotide binding]; other site 1401659001242 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1401659001243 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1401659001244 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1401659001245 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1401659001246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1401659001247 active site 1401659001248 phosphorylation site [posttranslational modification] 1401659001249 intermolecular recognition site; other site 1401659001250 dimerization interface [polypeptide binding]; other site 1401659001251 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1401659001252 DNA binding site [nucleotide binding] 1401659001253 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 1401659001254 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1401659001255 dimerization interface [polypeptide binding]; other site 1401659001256 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1401659001257 dimer interface [polypeptide binding]; other site 1401659001258 phosphorylation site [posttranslational modification] 1401659001259 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1401659001260 ATP binding site [chemical binding]; other site 1401659001261 G-X-G motif; other site 1401659001262 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1401659001263 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1401659001264 active site 1401659001265 substrate-binding site [chemical binding]; other site 1401659001266 metal-binding site [ion binding] 1401659001267 ATP binding site [chemical binding]; other site 1401659001268 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 1401659001269 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1401659001270 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1401659001271 dimerization interface [polypeptide binding]; other site 1401659001272 domain crossover interface; other site 1401659001273 redox-dependent activation switch; other site 1401659001274 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1401659001275 RNA binding surface [nucleotide binding]; other site 1401659001276 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1401659001277 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1401659001278 motif II; other site 1401659001279 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 1401659001280 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 1401659001281 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1401659001282 ADP-ribose binding site [chemical binding]; other site 1401659001283 dimer interface [polypeptide binding]; other site 1401659001284 active site 1401659001285 nudix motif; other site 1401659001286 metal binding site [ion binding]; metal-binding site 1401659001287 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 1401659001288 Transglycosylase; Region: Transgly; pfam00912 1401659001289 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1401659001290 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 1401659001291 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1401659001292 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 1401659001293 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 1401659001294 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1401659001295 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1401659001296 shikimate kinase; Reviewed; Region: aroK; PRK00131 1401659001297 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1401659001298 ADP binding site [chemical binding]; other site 1401659001299 magnesium binding site [ion binding]; other site 1401659001300 putative shikimate binding site; other site 1401659001301 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1401659001302 active site 1401659001303 dimer interface [polypeptide binding]; other site 1401659001304 metal binding site [ion binding]; metal-binding site 1401659001305 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 1401659001306 cell division protein DamX; Validated; Region: PRK10905 1401659001307 DNA adenine methylase; Provisional; Region: PRK10904 1401659001308 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1401659001309 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1401659001310 substrate binding site [chemical binding]; other site 1401659001311 hexamer interface [polypeptide binding]; other site 1401659001312 metal binding site [ion binding]; metal-binding site 1401659001313 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1401659001314 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1401659001315 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1401659001316 motif II; other site 1401659001317 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1401659001318 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1401659001319 active site 1401659001320 HIGH motif; other site 1401659001321 dimer interface [polypeptide binding]; other site 1401659001322 KMSKS motif; other site 1401659001323 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 1401659001324 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 1401659001325 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1401659001326 DNA-binding site [nucleotide binding]; DNA binding site 1401659001327 UTRA domain; Region: UTRA; pfam07702 1401659001328 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 1401659001329 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1401659001330 substrate binding site [chemical binding]; other site 1401659001331 ATP binding site [chemical binding]; other site 1401659001332 fructoselysine 3-epimerase; Provisional; Region: PRK09856 1401659001333 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1401659001334 AP (apurinic/apyrimidinic) site pocket; other site 1401659001335 DNA interaction; other site 1401659001336 Metal-binding active site; metal-binding site 1401659001337 fructoselysine-6-P-deglycase; Provisional; Region: frlB; PRK11382 1401659001338 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1401659001339 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1401659001340 dimer interface [polypeptide binding]; other site 1401659001341 active site 1401659001342 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 1401659001343 hypothetical protein; Provisional; Region: PHA02764 1401659001344 siroheme synthase; Provisional; Region: cysG; PRK10637 1401659001345 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1401659001346 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1401659001347 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1401659001348 active site 1401659001349 SAM binding site [chemical binding]; other site 1401659001350 homodimer interface [polypeptide binding]; other site 1401659001351 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1401659001352 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1401659001353 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1401659001354 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1401659001355 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1401659001356 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1401659001357 putative transporter; Provisional; Region: PRK03699 1401659001358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659001359 putative substrate translocation pore; other site 1401659001360 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 1401659001361 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1401659001362 substrate binding site [chemical binding]; other site 1401659001363 Protein of unknown function (DUF2559); Region: DUF2559; pfam10832 1401659001364 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 1401659001365 cell filamentation protein Fic; Provisional; Region: PRK10347 1401659001366 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1401659001367 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1401659001368 glutamine binding [chemical binding]; other site 1401659001369 catalytic triad [active] 1401659001370 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 1401659001371 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1401659001372 inhibitor-cofactor binding pocket; inhibition site 1401659001373 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659001374 catalytic residue [active] 1401659001375 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 1401659001376 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1401659001377 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1401659001378 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 1401659001379 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1401659001380 ligand binding site [chemical binding]; other site 1401659001381 flexible hinge region; other site 1401659001382 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1401659001383 putative switch regulator; other site 1401659001384 non-specific DNA interactions [nucleotide binding]; other site 1401659001385 DNA binding site [nucleotide binding] 1401659001386 sequence specific DNA binding site [nucleotide binding]; other site 1401659001387 putative cAMP binding site [chemical binding]; other site 1401659001388 hypothetical protein; Provisional; Region: PRK10738 1401659001389 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 1401659001390 active site 1401659001391 hypothetical protein; Provisional; Region: PRK04966 1401659001392 putative hydrolase; Provisional; Region: PRK10985 1401659001393 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1401659001394 nudix motif; other site 1401659001395 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1401659001396 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 1401659001397 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1401659001398 active site 1401659001399 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 1401659001400 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 1401659001401 active site 1401659001402 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 1401659001403 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1401659001404 Walker A/P-loop; other site 1401659001405 ATP binding site [chemical binding]; other site 1401659001406 Q-loop/lid; other site 1401659001407 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1401659001408 ABC transporter; Region: ABC_tran_2; pfam12848 1401659001409 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1401659001410 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1401659001411 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 1401659001412 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 1401659001413 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1401659001414 TrkA-N domain; Region: TrkA_N; pfam02254 1401659001415 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 1401659001416 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1401659001417 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1401659001418 SlyX; Region: SlyX; pfam04102 1401659001419 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 1401659001420 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1401659001421 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1401659001422 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1401659001423 YheO-like PAS domain; Region: PAS_6; pfam08348 1401659001424 HTH domain; Region: HTH_22; pfam13309 1401659001425 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 1401659001426 sulfur relay protein TusC; Validated; Region: PRK00211 1401659001427 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 1401659001428 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1401659001429 16S rRNA interaction site [nucleotide binding]; other site 1401659001430 streptomycin interaction site [chemical binding]; other site 1401659001431 23S rRNA interaction site [nucleotide binding]; other site 1401659001432 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1401659001433 30S ribosomal protein S7; Validated; Region: PRK05302 1401659001434 elongation factor G; Reviewed; Region: PRK00007 1401659001435 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1401659001436 G1 box; other site 1401659001437 putative GEF interaction site [polypeptide binding]; other site 1401659001438 GTP/Mg2+ binding site [chemical binding]; other site 1401659001439 Switch I region; other site 1401659001440 G2 box; other site 1401659001441 G3 box; other site 1401659001442 Switch II region; other site 1401659001443 G4 box; other site 1401659001444 G5 box; other site 1401659001445 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1401659001446 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1401659001447 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1401659001448 elongation factor Tu; Reviewed; Region: PRK00049 1401659001449 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1401659001450 G1 box; other site 1401659001451 GEF interaction site [polypeptide binding]; other site 1401659001452 GTP/Mg2+ binding site [chemical binding]; other site 1401659001453 Switch I region; other site 1401659001454 G2 box; other site 1401659001455 G3 box; other site 1401659001456 Switch II region; other site 1401659001457 G4 box; other site 1401659001458 G5 box; other site 1401659001459 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1401659001460 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1401659001461 Antibiotic Binding Site [chemical binding]; other site 1401659001462 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1401659001463 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1401659001464 heme binding site [chemical binding]; other site 1401659001465 ferroxidase pore; other site 1401659001466 ferroxidase diiron center [ion binding]; other site 1401659001467 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1401659001468 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 1401659001469 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1401659001470 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1401659001471 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1401659001472 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1401659001473 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1401659001474 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1401659001475 protein-rRNA interface [nucleotide binding]; other site 1401659001476 putative translocon binding site; other site 1401659001477 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1401659001478 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1401659001479 G-X-X-G motif; other site 1401659001480 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1401659001481 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1401659001482 23S rRNA interface [nucleotide binding]; other site 1401659001483 5S rRNA interface [nucleotide binding]; other site 1401659001484 putative antibiotic binding site [chemical binding]; other site 1401659001485 L25 interface [polypeptide binding]; other site 1401659001486 L27 interface [polypeptide binding]; other site 1401659001487 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1401659001488 23S rRNA interface [nucleotide binding]; other site 1401659001489 putative translocon interaction site; other site 1401659001490 signal recognition particle (SRP54) interaction site; other site 1401659001491 L23 interface [polypeptide binding]; other site 1401659001492 trigger factor interaction site; other site 1401659001493 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1401659001494 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1401659001495 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1401659001496 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1401659001497 RNA binding site [nucleotide binding]; other site 1401659001498 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1401659001499 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1401659001500 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1401659001501 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1401659001502 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1401659001503 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1401659001504 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1401659001505 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1401659001506 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1401659001507 23S rRNA interface [nucleotide binding]; other site 1401659001508 5S rRNA interface [nucleotide binding]; other site 1401659001509 L27 interface [polypeptide binding]; other site 1401659001510 L5 interface [polypeptide binding]; other site 1401659001511 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1401659001512 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1401659001513 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1401659001514 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1401659001515 23S rRNA binding site [nucleotide binding]; other site 1401659001516 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1401659001517 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1401659001518 SecY translocase; Region: SecY; pfam00344 1401659001519 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1401659001520 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1401659001521 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1401659001522 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1401659001523 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1401659001524 RNA binding surface [nucleotide binding]; other site 1401659001525 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1401659001526 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1401659001527 alphaNTD homodimer interface [polypeptide binding]; other site 1401659001528 alphaNTD - beta interaction site [polypeptide binding]; other site 1401659001529 alphaNTD - beta' interaction site [polypeptide binding]; other site 1401659001530 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1401659001531 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1401659001532 hypothetical protein; Provisional; Region: PRK10203 1401659001533 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 1401659001534 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1401659001535 DNA binding residues [nucleotide binding] 1401659001536 dimer interface [polypeptide binding]; other site 1401659001537 metal binding site [ion binding]; metal-binding site 1401659001538 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1401659001539 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1401659001540 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1401659001541 TrkA-N domain; Region: TrkA_N; pfam02254 1401659001542 TrkA-C domain; Region: TrkA_C; pfam02080 1401659001543 TrkA-N domain; Region: TrkA_N; pfam02254 1401659001544 TrkA-C domain; Region: TrkA_C; pfam02080 1401659001545 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1401659001546 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1401659001547 putative RNA binding site [nucleotide binding]; other site 1401659001548 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1401659001549 S-adenosylmethionine binding site [chemical binding]; other site 1401659001550 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1401659001551 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1401659001552 putative active site [active] 1401659001553 substrate binding site [chemical binding]; other site 1401659001554 putative cosubstrate binding site; other site 1401659001555 catalytic site [active] 1401659001556 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1401659001557 substrate binding site [chemical binding]; other site 1401659001558 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1401659001559 active site 1401659001560 catalytic residues [active] 1401659001561 metal binding site [ion binding]; metal-binding site 1401659001562 hypothetical protein; Provisional; Region: PRK10736 1401659001563 DNA protecting protein DprA; Region: dprA; TIGR00732 1401659001564 hypothetical protein; Validated; Region: PRK03430 1401659001565 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1401659001566 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1401659001567 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1401659001568 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 1401659001569 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1401659001570 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1401659001571 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1401659001572 shikimate binding site; other site 1401659001573 NAD(P) binding site [chemical binding]; other site 1401659001574 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 1401659001575 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1401659001576 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1401659001577 trimer interface [polypeptide binding]; other site 1401659001578 putative metal binding site [ion binding]; other site 1401659001579 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1401659001580 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1401659001581 proposed active site lysine [active] 1401659001582 conserved cys residue [active] 1401659001583 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 1401659001584 malate synthase A; Region: malate_syn_A; TIGR01344 1401659001585 active site 1401659001586 isocitrate lyase; Provisional; Region: PRK15063 1401659001587 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1401659001588 tetramer interface [polypeptide binding]; other site 1401659001589 active site 1401659001590 Mg2+/Mn2+ binding site [ion binding]; other site 1401659001591 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 1401659001592 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 1401659001593 transcriptional repressor IclR; Provisional; Region: PRK11569 1401659001594 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1401659001595 Bacterial transcriptional regulator; Region: IclR; pfam01614 1401659001596 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1401659001597 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1401659001598 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1401659001599 substrate binding pocket [chemical binding]; other site 1401659001600 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1401659001601 B12 binding site [chemical binding]; other site 1401659001602 cobalt ligand [ion binding]; other site 1401659001603 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1401659001604 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1401659001605 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1401659001606 probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684 1401659001607 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 1401659001608 hypothetical protein; Provisional; Region: PRK10515 1401659001609 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1401659001610 Sodium Bile acid symporter family; Region: SBF; pfam01758 1401659001611 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 1401659001612 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 1401659001613 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1401659001614 Walker A motif; other site 1401659001615 ATP binding site [chemical binding]; other site 1401659001616 Walker B motif; other site 1401659001617 arginine finger; other site 1401659001618 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1401659001619 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1401659001620 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1401659001621 hypothetical protein; Reviewed; Region: PRK09588 1401659001622 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 1401659001623 aspartate kinase III; Validated; Region: PRK09084 1401659001624 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1401659001625 nucleotide binding site [chemical binding]; other site 1401659001626 substrate binding site [chemical binding]; other site 1401659001627 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 1401659001628 lysine allosteric regulatory site; other site 1401659001629 dimer interface [polypeptide binding]; other site 1401659001630 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 1401659001631 dimer interface [polypeptide binding]; other site 1401659001632 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1401659001633 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1401659001634 active site 1401659001635 dimer interface [polypeptide binding]; other site 1401659001636 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1401659001637 dimer interface [polypeptide binding]; other site 1401659001638 active site 1401659001639 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 1401659001640 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 1401659001641 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 1401659001642 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 1401659001643 putative trimer interface [polypeptide binding]; other site 1401659001644 putative active site [active] 1401659001645 putative substrate binding site [chemical binding]; other site 1401659001646 putative CoA binding site [chemical binding]; other site 1401659001647 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1401659001648 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659001649 dimer interface [polypeptide binding]; other site 1401659001650 conserved gate region; other site 1401659001651 putative PBP binding loops; other site 1401659001652 ABC-ATPase subunit interface; other site 1401659001653 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659001654 dimer interface [polypeptide binding]; other site 1401659001655 conserved gate region; other site 1401659001656 ABC-ATPase subunit interface; other site 1401659001657 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 1401659001658 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1401659001659 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 1401659001660 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1401659001661 Walker A/P-loop; other site 1401659001662 ATP binding site [chemical binding]; other site 1401659001663 Q-loop/lid; other site 1401659001664 ABC transporter signature motif; other site 1401659001665 Walker B; other site 1401659001666 D-loop; other site 1401659001667 H-loop/switch region; other site 1401659001668 TOBE domain; Region: TOBE_2; pfam08402 1401659001669 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1401659001670 trimer interface; other site 1401659001671 sugar binding site [chemical binding]; other site 1401659001672 maltose regulon periplasmic protein; Provisional; Region: PRK10564 1401659001673 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 1401659001674 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 1401659001675 UbiA prenyltransferase family; Region: UbiA; pfam01040 1401659001676 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 1401659001677 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1401659001678 putative acyl-acceptor binding pocket; other site 1401659001679 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1401659001680 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1401659001681 LexA repressor; Validated; Region: PRK00215 1401659001682 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1401659001683 Catalytic site [active] 1401659001684 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1401659001685 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 1401659001686 hypothetical protein; Provisional; Region: PRK10428 1401659001687 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1401659001688 metal binding site 2 [ion binding]; metal-binding site 1401659001689 putative DNA binding helix; other site 1401659001690 metal binding site 1 [ion binding]; metal-binding site 1401659001691 dimer interface [polypeptide binding]; other site 1401659001692 structural Zn2+ binding site [ion binding]; other site 1401659001693 Cupin domain; Region: Cupin_2; cl17218 1401659001694 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 1401659001695 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1401659001696 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1401659001697 FMN binding site [chemical binding]; other site 1401659001698 active site 1401659001699 catalytic residues [active] 1401659001700 substrate binding site [chemical binding]; other site 1401659001701 phage shock protein G; Reviewed; Region: pspG; PRK09459 1401659001702 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1401659001703 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1401659001704 NADP binding site [chemical binding]; other site 1401659001705 dimer interface [polypeptide binding]; other site 1401659001706 replicative DNA helicase; Provisional; Region: PRK08006 1401659001707 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1401659001708 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1401659001709 Walker A motif; other site 1401659001710 ATP binding site [chemical binding]; other site 1401659001711 Walker B motif; other site 1401659001712 DNA binding loops [nucleotide binding] 1401659001713 alanine racemase; Reviewed; Region: alr; PRK00053 1401659001714 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1401659001715 active site 1401659001716 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1401659001717 substrate binding site [chemical binding]; other site 1401659001718 catalytic residues [active] 1401659001719 dimer interface [polypeptide binding]; other site 1401659001720 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1401659001721 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1401659001722 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659001723 homodimer interface [polypeptide binding]; other site 1401659001724 catalytic residue [active] 1401659001725 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1401659001726 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1401659001727 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1401659001728 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 1401659001729 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1401659001730 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1401659001731 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1401659001732 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1401659001733 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1401659001734 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1401659001735 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1401659001736 dimer interface [polypeptide binding]; other site 1401659001737 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1401659001738 ssDNA binding site [nucleotide binding]; other site 1401659001739 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1401659001740 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1401659001741 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1401659001742 metal binding site [ion binding]; metal-binding site 1401659001743 active site 1401659001744 I-site; other site 1401659001745 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1401659001746 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1401659001747 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1401659001748 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1401659001749 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1401659001750 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 1401659001751 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 1401659001752 DNA binding residues [nucleotide binding] 1401659001753 dimer interface [polypeptide binding]; other site 1401659001754 [2Fe-2S] cluster binding site [ion binding]; other site 1401659001755 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1401659001756 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1401659001757 putative C-terminal domain interface [polypeptide binding]; other site 1401659001758 putative GSH binding site (G-site) [chemical binding]; other site 1401659001759 putative dimer interface [polypeptide binding]; other site 1401659001760 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 1401659001761 putative N-terminal domain interface [polypeptide binding]; other site 1401659001762 putative dimer interface [polypeptide binding]; other site 1401659001763 putative substrate binding pocket (H-site) [chemical binding]; other site 1401659001764 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1401659001765 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1401659001766 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1401659001767 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1401659001768 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1401659001769 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1401659001770 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1401659001771 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1401659001772 Na binding site [ion binding]; other site 1401659001773 Predicted membrane protein [Function unknown]; Region: COG3162 1401659001774 acetyl-CoA synthetase; Provisional; Region: PRK00174 1401659001775 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1401659001776 active site 1401659001777 CoA binding site [chemical binding]; other site 1401659001778 acyl-activating enzyme (AAE) consensus motif; other site 1401659001779 AMP binding site [chemical binding]; other site 1401659001780 acetate binding site [chemical binding]; other site 1401659001781 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 1401659001782 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1401659001783 Hok/gef family; Region: HOK_GEF; pfam01848 1401659001784 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 1401659001785 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1401659001786 ATP binding site [chemical binding]; other site 1401659001787 Mg2+ binding site [ion binding]; other site 1401659001788 G-X-G motif; other site 1401659001789 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 1401659001790 hypothetical protein; Provisional; Region: PRK10220 1401659001791 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1401659001792 PhnA protein; Region: PhnA; pfam03831 1401659001793 hypothetical protein; Provisional; Region: PRK09866 1401659001794 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1401659001795 G1 box; other site 1401659001796 GTP/Mg2+ binding site [chemical binding]; other site 1401659001797 G2 box; other site 1401659001798 Switch I region; other site 1401659001799 G3 box; other site 1401659001800 Switch II region; other site 1401659001801 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1401659001802 G3 box; other site 1401659001803 Switch II region; other site 1401659001804 GTP/Mg2+ binding site [chemical binding]; other site 1401659001805 G4 box; other site 1401659001806 G5 box; other site 1401659001807 YjcZ-like protein; Region: YjcZ; pfam13990 1401659001808 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 1401659001809 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1401659001810 putative S-transferase; Provisional; Region: PRK11752 1401659001811 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1401659001812 C-terminal domain interface [polypeptide binding]; other site 1401659001813 GSH binding site (G-site) [chemical binding]; other site 1401659001814 dimer interface [polypeptide binding]; other site 1401659001815 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 1401659001816 dimer interface [polypeptide binding]; other site 1401659001817 N-terminal domain interface [polypeptide binding]; other site 1401659001818 active site 1401659001819 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 1401659001820 putative transcriptional regulator; Provisional; Region: PRK11640 1401659001821 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 1401659001822 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1401659001823 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1401659001824 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1401659001825 DsbD alpha interface [polypeptide binding]; other site 1401659001826 catalytic residues [active] 1401659001827 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 1401659001828 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1401659001829 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1401659001830 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1401659001831 Aspartase; Region: Aspartase; cd01357 1401659001832 active sites [active] 1401659001833 tetramer interface [polypeptide binding]; other site 1401659001834 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 1401659001835 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1401659001836 oligomerisation interface [polypeptide binding]; other site 1401659001837 mobile loop; other site 1401659001838 roof hairpin; other site 1401659001839 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1401659001840 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1401659001841 ring oligomerisation interface [polypeptide binding]; other site 1401659001842 ATP/Mg binding site [chemical binding]; other site 1401659001843 stacking interactions; other site 1401659001844 hinge regions; other site 1401659001845 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 1401659001846 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 1401659001847 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1401659001848 FeS/SAM binding site; other site 1401659001849 elongation factor P; Validated; Region: PRK00529 1401659001850 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1401659001851 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1401659001852 RNA binding site [nucleotide binding]; other site 1401659001853 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1401659001854 RNA binding site [nucleotide binding]; other site 1401659001855 Predicted small secreted protein [Function unknown]; Region: COG5510 1401659001856 Entericidin EcnA/B family; Region: Entericidin; cl02322 1401659001857 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1401659001858 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1401659001859 DNA binding residues [nucleotide binding] 1401659001860 dimerization interface [polypeptide binding]; other site 1401659001861 multidrug efflux system protein; Provisional; Region: PRK11431 1401659001862 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1401659001863 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 1401659001864 Iron-sulfur protein interface; other site 1401659001865 proximal quinone binding site [chemical binding]; other site 1401659001866 C-subunit interface; other site 1401659001867 distal quinone binding site; other site 1401659001868 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 1401659001869 D-subunit interface [polypeptide binding]; other site 1401659001870 Iron-sulfur protein interface; other site 1401659001871 proximal quinone binding site [chemical binding]; other site 1401659001872 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 1401659001873 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1401659001874 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 1401659001875 L-aspartate oxidase; Provisional; Region: PRK06175 1401659001876 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1401659001877 poxB regulator PoxA; Provisional; Region: PRK09350 1401659001878 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1401659001879 motif 1; other site 1401659001880 dimer interface [polypeptide binding]; other site 1401659001881 active site 1401659001882 motif 2; other site 1401659001883 motif 3; other site 1401659001884 putative mechanosensitive channel protein; Provisional; Region: PRK10929 1401659001885 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1401659001886 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1401659001887 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1401659001888 GTPase RsgA; Reviewed; Region: PRK12288 1401659001889 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1401659001890 RNA binding site [nucleotide binding]; other site 1401659001891 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1401659001892 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1401659001893 GTP/Mg2+ binding site [chemical binding]; other site 1401659001894 G4 box; other site 1401659001895 G5 box; other site 1401659001896 G1 box; other site 1401659001897 Switch I region; other site 1401659001898 G2 box; other site 1401659001899 G3 box; other site 1401659001900 Switch II region; other site 1401659001901 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1401659001902 catalytic site [active] 1401659001903 putative active site [active] 1401659001904 putative substrate binding site [chemical binding]; other site 1401659001905 dimer interface [polypeptide binding]; other site 1401659001906 epoxyqueuosine reductase; Region: TIGR00276 1401659001907 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1401659001908 putative carbohydrate kinase; Provisional; Region: PRK10565 1401659001909 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1401659001910 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1401659001911 putative substrate binding site [chemical binding]; other site 1401659001912 putative ATP binding site [chemical binding]; other site 1401659001913 ADP-binding protein; Provisional; Region: PRK10646 1401659001914 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 1401659001915 AMIN domain; Region: AMIN; pfam11741 1401659001916 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1401659001917 active site 1401659001918 metal binding site [ion binding]; metal-binding site 1401659001919 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1401659001920 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1401659001921 ATP binding site [chemical binding]; other site 1401659001922 Mg2+ binding site [ion binding]; other site 1401659001923 G-X-G motif; other site 1401659001924 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1401659001925 ATP binding site [chemical binding]; other site 1401659001926 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1401659001927 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1401659001928 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1401659001929 Sm and related proteins; Region: Sm_like; cl00259 1401659001930 hexamer interface [polypeptide binding]; other site 1401659001931 Sm1 motif; other site 1401659001932 heptamer interface [polypeptide binding]; other site 1401659001933 RNA binding site [nucleotide binding]; other site 1401659001934 Sm2 motif; other site 1401659001935 GTPase HflX; Provisional; Region: PRK11058 1401659001936 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1401659001937 HflX GTPase family; Region: HflX; cd01878 1401659001938 G1 box; other site 1401659001939 GTP/Mg2+ binding site [chemical binding]; other site 1401659001940 Switch I region; other site 1401659001941 G2 box; other site 1401659001942 G3 box; other site 1401659001943 Switch II region; other site 1401659001944 G4 box; other site 1401659001945 G5 box; other site 1401659001946 FtsH protease regulator HflK; Provisional; Region: PRK10930 1401659001947 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 1401659001948 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1401659001949 FtsH protease regulator HflC; Provisional; Region: PRK11029 1401659001950 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1401659001951 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 1401659001952 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1401659001953 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1401659001954 GDP-binding site [chemical binding]; other site 1401659001955 ACT binding site; other site 1401659001956 IMP binding site; other site 1401659001957 Predicted transcriptional regulator [Transcription]; Region: COG1959 1401659001958 transcriptional repressor NsrR; Provisional; Region: PRK11014 1401659001959 exoribonuclease R; Provisional; Region: PRK11642 1401659001960 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1401659001961 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1401659001962 RNB domain; Region: RNB; pfam00773 1401659001963 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1401659001964 RNA binding site [nucleotide binding]; other site 1401659001965 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1401659001966 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1401659001967 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1401659001968 Predicted membrane protein [Function unknown]; Region: COG3766 1401659001969 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1401659001970 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1401659001971 Protein of unknown function (DUF1190); Region: DUF1190; cl10031 1401659001972 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1401659001973 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1401659001974 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1401659001975 active site 1401659001976 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1401659001977 dimerization interface [polypeptide binding]; other site 1401659001978 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1401659001979 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1401659001980 dimer interface [polypeptide binding]; other site 1401659001981 putative CheW interface [polypeptide binding]; other site 1401659001982 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1401659001983 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 1401659001984 esterase; Provisional; Region: PRK10566 1401659001985 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1401659001986 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1401659001987 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1401659001988 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1401659001989 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1401659001990 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1401659001991 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 1401659001992 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 1401659001993 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 1401659001994 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 1401659001995 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1401659001996 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1401659001997 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1401659001998 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 1401659001999 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1401659002000 Hemerythrin-like domain; Region: Hr-like; cd12108 1401659002001 Fe binding site [ion binding]; other site 1401659002002 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1401659002003 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1401659002004 dimer interface [polypeptide binding]; other site 1401659002005 ligand binding site [chemical binding]; other site 1401659002006 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1401659002007 dimerization interface [polypeptide binding]; other site 1401659002008 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1401659002009 dimer interface [polypeptide binding]; other site 1401659002010 putative CheW interface [polypeptide binding]; other site 1401659002011 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1401659002012 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 1401659002013 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1401659002014 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1401659002015 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1401659002016 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1401659002017 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1401659002018 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1401659002019 NADP binding site [chemical binding]; other site 1401659002020 Predicted transcriptional regulators [Transcription]; Region: COG1733 1401659002021 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1401659002022 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 1401659002023 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1401659002024 active site 1401659002025 metal binding site [ion binding]; metal-binding site 1401659002026 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1401659002027 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1401659002028 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1401659002029 active site 1401659002030 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; cl17398 1401659002031 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 1401659002032 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1401659002033 Domain of unknown function DUF21; Region: DUF21; pfam01595 1401659002034 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1401659002035 Transporter associated domain; Region: CorC_HlyC; smart01091 1401659002036 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1401659002037 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1401659002038 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1401659002039 Surface antigen; Region: Bac_surface_Ag; pfam01103 1401659002040 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1401659002041 Family of unknown function (DUF490); Region: DUF490; pfam04357 1401659002042 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1401659002043 dimerization interface [polypeptide binding]; other site 1401659002044 putative active site pocket [active] 1401659002045 putative catalytic residue [active] 1401659002046 Fimbrial protein; Region: Fimbrial; cl01416 1401659002047 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1401659002048 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 1401659002049 PapC N-terminal domain; Region: PapC_N; pfam13954 1401659002050 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1401659002051 PapC C-terminal domain; Region: PapC_C; pfam13953 1401659002052 fimbrial chaperone protein StdC; Provisional; Region: PRK15254 1401659002053 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1401659002054 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1401659002055 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1401659002056 Fimbrial protein; Region: Fimbrial; pfam00419 1401659002057 Fimbrial protein; Region: Fimbrial; cl01416 1401659002058 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1401659002059 O-Antigen ligase; Region: Wzy_C; pfam04932 1401659002060 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1401659002061 dimerization interface [polypeptide binding]; other site 1401659002062 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1401659002063 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1401659002064 dimer interface [polypeptide binding]; other site 1401659002065 putative CheW interface [polypeptide binding]; other site 1401659002066 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1401659002067 dimer interface [polypeptide binding]; other site 1401659002068 substrate binding site [chemical binding]; other site 1401659002069 metal binding sites [ion binding]; metal-binding site 1401659002070 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 1401659002071 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1401659002072 putative ligand binding site [chemical binding]; other site 1401659002073 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1401659002074 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1401659002075 Walker A/P-loop; other site 1401659002076 ATP binding site [chemical binding]; other site 1401659002077 Q-loop/lid; other site 1401659002078 ABC transporter signature motif; other site 1401659002079 Walker B; other site 1401659002080 D-loop; other site 1401659002081 H-loop/switch region; other site 1401659002082 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1401659002083 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1401659002084 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1401659002085 TM-ABC transporter signature motif; other site 1401659002086 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1401659002087 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1401659002088 TM-ABC transporter signature motif; other site 1401659002089 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1401659002090 dimer interface [polypeptide binding]; other site 1401659002091 ligand binding site [chemical binding]; other site 1401659002092 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1401659002093 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1401659002094 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1401659002095 dimer interface [polypeptide binding]; other site 1401659002096 putative CheW interface [polypeptide binding]; other site 1401659002097 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1401659002098 AMP binding site [chemical binding]; other site 1401659002099 metal binding site [ion binding]; metal-binding site 1401659002100 active site 1401659002101 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1401659002102 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1401659002103 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1401659002104 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1401659002105 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 1401659002106 active site 1401659002107 catalytic residues [active] 1401659002108 hypothetical protein; Provisional; Region: PRK05255 1401659002109 peptidase PmbA; Provisional; Region: PRK11040 1401659002110 Cytochrome b562; Region: Cytochrom_B562; cl01546 1401659002111 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 1401659002112 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; cl11916 1401659002113 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 1401659002114 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 1401659002115 Domain of unknown function (DUF4310); Region: DUF4310; pfam14187 1401659002116 dihydroorotase; Provisional; Region: PRK09237 1401659002117 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1401659002118 active site 1401659002119 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 1401659002120 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 1401659002121 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1401659002122 HTH domain; Region: HTH_11; pfam08279 1401659002123 Mga helix-turn-helix domain; Region: Mga; pfam05043 1401659002124 PRD domain; Region: PRD; pfam00874 1401659002125 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1401659002126 active site 1401659002127 P-loop; other site 1401659002128 phosphorylation site [posttranslational modification] 1401659002129 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1401659002130 active site 1401659002131 phosphorylation site [posttranslational modification] 1401659002132 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 1401659002133 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1401659002134 FeS/SAM binding site; other site 1401659002135 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1401659002136 ATP cone domain; Region: ATP-cone; pfam03477 1401659002137 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1401659002138 effector binding site; other site 1401659002139 active site 1401659002140 Zn binding site [ion binding]; other site 1401659002141 glycine loop; other site 1401659002142 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 1401659002143 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659002144 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1401659002145 putative effector binding pocket; other site 1401659002146 dimerization interface [polypeptide binding]; other site 1401659002147 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1401659002148 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 1401659002149 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1401659002150 Ca binding site [ion binding]; other site 1401659002151 active site 1401659002152 catalytic site [active] 1401659002153 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1401659002154 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 1401659002155 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1401659002156 active site turn [active] 1401659002157 phosphorylation site [posttranslational modification] 1401659002158 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1401659002159 trehalose repressor; Provisional; Region: treR; PRK09492 1401659002160 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1401659002161 DNA binding site [nucleotide binding] 1401659002162 domain linker motif; other site 1401659002163 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 1401659002164 dimerization interface [polypeptide binding]; other site 1401659002165 ligand binding site [chemical binding]; other site 1401659002166 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1401659002167 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1401659002168 glutaredoxin 2; Provisional; Region: PRK10387 1401659002169 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 1401659002170 C-terminal domain interface [polypeptide binding]; other site 1401659002171 GSH binding site (G-site) [chemical binding]; other site 1401659002172 catalytic residues [active] 1401659002173 putative dimer interface [polypeptide binding]; other site 1401659002174 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 1401659002175 N-terminal domain interface [polypeptide binding]; other site 1401659002176 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1401659002177 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1401659002178 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1401659002179 active site 1401659002180 catalytic tetrad [active] 1401659002181 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1401659002182 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1401659002183 dimer interface [polypeptide binding]; other site 1401659002184 active site 1401659002185 metal binding site [ion binding]; metal-binding site 1401659002186 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1401659002187 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1401659002188 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1401659002189 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1401659002190 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1401659002191 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1401659002192 cystathionine beta-lyase; Provisional; Region: PRK08114 1401659002193 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1401659002194 homodimer interface [polypeptide binding]; other site 1401659002195 substrate-cofactor binding pocket; other site 1401659002196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659002197 catalytic residue [active] 1401659002198 biopolymer transport protein ExbB; Provisional; Region: PRK10414 1401659002199 biopolymer transport protein ExbD; Provisional; Region: PRK11267 1401659002200 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1401659002201 oxidoreductase; Provisional; Region: PRK07985 1401659002202 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1401659002203 NAD binding site [chemical binding]; other site 1401659002204 metal binding site [ion binding]; metal-binding site 1401659002205 active site 1401659002206 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 1401659002207 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1401659002208 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1401659002209 hypothetical protein; Provisional; Region: PRK05208 1401659002210 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1401659002211 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1401659002212 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1401659002213 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1401659002214 methionine cluster; other site 1401659002215 active site 1401659002216 phosphorylation site [posttranslational modification] 1401659002217 metal binding site [ion binding]; metal-binding site 1401659002218 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1401659002219 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1401659002220 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1401659002221 active site 1401659002222 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1401659002223 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1401659002224 DNA binding site [nucleotide binding] 1401659002225 domain linker motif; other site 1401659002226 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1401659002227 ligand binding site [chemical binding]; other site 1401659002228 Predicted membrane protein (DUF2238); Region: DUF2238; cl01464 1401659002229 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 1401659002230 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1401659002231 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1401659002232 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 1401659002233 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 1401659002234 Peptidase family M23; Region: Peptidase_M23; pfam01551 1401659002235 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 1401659002236 VRR-NUC domain; Region: VRR_NUC; cl17748 1401659002237 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 1401659002238 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 1401659002239 Protein of unknown function (DUF554); Region: DUF554; pfam04474 1401659002240 ornithine decarboxylase; Provisional; Region: PRK13578 1401659002241 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1401659002242 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1401659002243 homodimer interface [polypeptide binding]; other site 1401659002244 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659002245 catalytic residue [active] 1401659002246 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1401659002247 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1401659002248 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1401659002249 active site 1401659002250 phosphorylation site [posttranslational modification] 1401659002251 intermolecular recognition site; other site 1401659002252 dimerization interface [polypeptide binding]; other site 1401659002253 Transcriptional regulator; Region: CitT; pfam12431 1401659002254 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1401659002255 PAS domain; Region: PAS; smart00091 1401659002256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1401659002257 ATP binding site [chemical binding]; other site 1401659002258 Mg2+ binding site [ion binding]; other site 1401659002259 G-X-G motif; other site 1401659002260 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 1401659002261 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1401659002262 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1401659002263 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 1401659002264 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1401659002265 active site 1401659002266 nucleotide binding site [chemical binding]; other site 1401659002267 HIGH motif; other site 1401659002268 KMSKS motif; other site 1401659002269 citrate lyase subunit gamma; Provisional; Region: PRK13253 1401659002270 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1401659002271 Coenzyme A transferase; Region: CoA_trans; cl17247 1401659002272 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 1401659002273 murein transglycosylase C; Provisional; Region: mltC; PRK11671 1401659002274 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 1401659002275 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1401659002276 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1401659002277 catalytic residue [active] 1401659002278 oxidative damage protection protein; Provisional; Region: PRK05408 1401659002279 adenine DNA glycosylase; Provisional; Region: PRK10880 1401659002280 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1401659002281 minor groove reading motif; other site 1401659002282 helix-hairpin-helix signature motif; other site 1401659002283 substrate binding pocket [chemical binding]; other site 1401659002284 active site 1401659002285 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1401659002286 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1401659002287 DNA binding and oxoG recognition site [nucleotide binding] 1401659002288 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1401659002289 hypothetical protein; Provisional; Region: PRK11702 1401659002290 hypothetical protein; Provisional; Region: PRK10626 1401659002291 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 1401659002292 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 1401659002293 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 1401659002294 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1401659002295 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1401659002296 Uncharacterized small protein [Function unknown]; Region: COG2879 1401659002297 carbon starvation protein A; Provisional; Region: PRK15015 1401659002298 Carbon starvation protein CstA; Region: CstA; pfam02554 1401659002299 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1401659002300 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1401659002301 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1401659002302 dimerization interface [polypeptide binding]; other site 1401659002303 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1401659002304 dimer interface [polypeptide binding]; other site 1401659002305 putative CheW interface [polypeptide binding]; other site 1401659002306 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1401659002307 active site lid residues [active] 1401659002308 substrate binding pocket [chemical binding]; other site 1401659002309 catalytic residues [active] 1401659002310 substrate-Mg2+ binding site; other site 1401659002311 aspartate-rich region 1; other site 1401659002312 aspartate-rich region 2; other site 1401659002313 phytoene desaturase; Region: crtI_fam; TIGR02734 1401659002314 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1401659002315 Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834 1401659002316 lycopene cyclase; Region: lycopene_cycl; TIGR01789 1401659002317 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1401659002318 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1401659002319 active site 1401659002320 TDP-binding site; other site 1401659002321 acceptor substrate-binding pocket; other site 1401659002322 homodimer interface [polypeptide binding]; other site 1401659002323 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1401659002324 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1401659002325 homotetramer interface [polypeptide binding]; other site 1401659002326 FMN binding site [chemical binding]; other site 1401659002327 homodimer contacts [polypeptide binding]; other site 1401659002328 putative active site [active] 1401659002329 putative substrate binding site [chemical binding]; other site 1401659002330 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1401659002331 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1401659002332 substrate binding pocket [chemical binding]; other site 1401659002333 chain length determination region; other site 1401659002334 substrate-Mg2+ binding site; other site 1401659002335 catalytic residues [active] 1401659002336 aspartate-rich region 1; other site 1401659002337 active site lid residues [active] 1401659002338 aspartate-rich region 2; other site 1401659002339 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 1401659002340 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1401659002341 active site 1401659002342 SUMO-1 interface [polypeptide binding]; other site 1401659002343 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1401659002344 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1401659002345 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1401659002346 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1401659002347 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1401659002348 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1401659002349 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1401659002350 DNA binding residues [nucleotide binding] 1401659002351 DNA primase; Validated; Region: dnaG; PRK05667 1401659002352 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1401659002353 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1401659002354 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1401659002355 active site 1401659002356 metal binding site [ion binding]; metal-binding site 1401659002357 interdomain interaction site; other site 1401659002358 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1401659002359 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 1401659002360 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1401659002361 UGMP family protein; Validated; Region: PRK09604 1401659002362 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1401659002363 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1401659002364 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1401659002365 homooctamer interface [polypeptide binding]; other site 1401659002366 active site 1401659002367 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1401659002368 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1401659002369 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1401659002370 active site 1401659002371 NTP binding site [chemical binding]; other site 1401659002372 metal binding triad [ion binding]; metal-binding site 1401659002373 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1401659002374 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1401659002375 Zn2+ binding site [ion binding]; other site 1401659002376 Mg2+ binding site [ion binding]; other site 1401659002377 SH3 domain-containing protein; Provisional; Region: PRK10884 1401659002378 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1401659002379 Uncharacterized conserved protein [Function unknown]; Region: COG3025 1401659002380 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 1401659002381 putative active site [active] 1401659002382 putative metal binding residues [ion binding]; other site 1401659002383 signature motif; other site 1401659002384 putative triphosphate binding site [ion binding]; other site 1401659002385 CHAD domain; Region: CHAD; pfam05235 1401659002386 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1401659002387 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1401659002388 metal binding triad; other site 1401659002389 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1401659002390 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1401659002391 metal binding triad; other site 1401659002392 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1401659002393 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 1401659002394 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1401659002395 putative ribose interaction site [chemical binding]; other site 1401659002396 putative ADP binding site [chemical binding]; other site 1401659002397 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1401659002398 active site 1401659002399 nucleotide binding site [chemical binding]; other site 1401659002400 HIGH motif; other site 1401659002401 KMSKS motif; other site 1401659002402 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 1401659002403 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 1401659002404 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1401659002405 zinc transporter ZupT; Provisional; Region: PRK04201 1401659002406 ZIP Zinc transporter; Region: Zip; pfam02535 1401659002407 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1401659002408 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1401659002409 putative active site [active] 1401659002410 metal binding site [ion binding]; metal-binding site 1401659002411 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1401659002412 hypothetical protein; Provisional; Region: PRK11653 1401659002413 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 1401659002414 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 1401659002415 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1401659002416 dimer interface [polypeptide binding]; other site 1401659002417 ADP-ribose binding site [chemical binding]; other site 1401659002418 active site 1401659002419 nudix motif; other site 1401659002420 metal binding site [ion binding]; metal-binding site 1401659002421 putative dehydrogenase; Provisional; Region: PRK11039 1401659002422 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1401659002423 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1401659002424 active site 1401659002425 metal binding site [ion binding]; metal-binding site 1401659002426 hexamer interface [polypeptide binding]; other site 1401659002427 esterase YqiA; Provisional; Region: PRK11071 1401659002428 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1401659002429 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 1401659002430 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1401659002431 ATP binding site [chemical binding]; other site 1401659002432 Mg2+ binding site [ion binding]; other site 1401659002433 G-X-G motif; other site 1401659002434 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1401659002435 anchoring element; other site 1401659002436 dimer interface [polypeptide binding]; other site 1401659002437 ATP binding site [chemical binding]; other site 1401659002438 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1401659002439 active site 1401659002440 metal binding site [ion binding]; metal-binding site 1401659002441 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1401659002442 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 1401659002443 Coenzyme A transferase; Region: CoA_trans; cl17247 1401659002444 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 1401659002445 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 1401659002446 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 1401659002447 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; pfam06833 1401659002448 Membrane transport protein; Region: Mem_trans; cl09117 1401659002449 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 1401659002450 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 1401659002451 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1401659002452 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 1401659002453 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1401659002454 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659002455 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1401659002456 dimerization interface [polypeptide binding]; other site 1401659002457 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1401659002458 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1401659002459 heme binding site [chemical binding]; other site 1401659002460 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1401659002461 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1401659002462 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1401659002463 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1401659002464 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1401659002465 CAP-like domain; other site 1401659002466 active site 1401659002467 primary dimer interface [polypeptide binding]; other site 1401659002468 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 1401659002469 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1401659002470 putative acyl-acceptor binding pocket; other site 1401659002471 FtsI repressor; Provisional; Region: PRK10883 1401659002472 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1401659002473 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1401659002474 HemN family oxidoreductase; Provisional; Region: PRK05660 1401659002475 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1401659002476 FeS/SAM binding site; other site 1401659002477 HemN C-terminal domain; Region: HemN_C; pfam06969 1401659002478 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1401659002479 active site 1401659002480 dimerization interface [polypeptide binding]; other site 1401659002481 hypothetical protein; Validated; Region: PRK05090 1401659002482 YGGT family; Region: YGGT; pfam02325 1401659002483 Predicted integral membrane protein [Function unknown]; Region: COG0762 1401659002484 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 1401659002485 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1401659002486 catalytic residue [active] 1401659002487 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1401659002488 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1401659002489 Walker A motif; other site 1401659002490 ATP binding site [chemical binding]; other site 1401659002491 Walker B motif; other site 1401659002492 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 1401659002493 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1401659002494 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1401659002495 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1401659002496 hypothetical protein; Validated; Region: PRK00228 1401659002497 glutathione synthetase; Provisional; Region: PRK05246 1401659002498 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1401659002499 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1401659002500 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1401659002501 RNA methyltransferase, RsmE family; Region: TIGR00046 1401659002502 DNA-specific endonuclease I; Provisional; Region: PRK15137 1401659002503 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 1401659002504 hypothetical protein; Provisional; Region: PRK04860 1401659002505 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1401659002506 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1401659002507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659002508 putative substrate translocation pore; other site 1401659002509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659002510 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1401659002511 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1401659002512 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1401659002513 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1401659002514 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 1401659002515 arginine decarboxylase; Provisional; Region: PRK05354 1401659002516 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1401659002517 dimer interface [polypeptide binding]; other site 1401659002518 active site 1401659002519 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1401659002520 catalytic residues [active] 1401659002521 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1401659002522 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1401659002523 agmatinase; Region: agmatinase; TIGR01230 1401659002524 oligomer interface [polypeptide binding]; other site 1401659002525 putative active site [active] 1401659002526 Mn binding site [ion binding]; other site 1401659002527 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1401659002528 transketolase; Reviewed; Region: PRK12753 1401659002529 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1401659002530 TPP-binding site [chemical binding]; other site 1401659002531 dimer interface [polypeptide binding]; other site 1401659002532 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1401659002533 PYR/PP interface [polypeptide binding]; other site 1401659002534 dimer interface [polypeptide binding]; other site 1401659002535 TPP binding site [chemical binding]; other site 1401659002536 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1401659002537 ferredoxin-type protein NapF; Region: napF; TIGR00402 1401659002538 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 1401659002539 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1401659002540 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1401659002541 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1401659002542 Phosphoglycerate kinase; Region: PGK; pfam00162 1401659002543 substrate binding site [chemical binding]; other site 1401659002544 hinge regions; other site 1401659002545 ADP binding site [chemical binding]; other site 1401659002546 catalytic site [active] 1401659002547 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1401659002548 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 1401659002549 active site 1401659002550 intersubunit interface [polypeptide binding]; other site 1401659002551 zinc binding site [ion binding]; other site 1401659002552 Na+ binding site [ion binding]; other site 1401659002553 mechanosensitive channel MscS; Provisional; Region: PRK10334 1401659002554 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1401659002555 arginine exporter protein; Provisional; Region: PRK09304 1401659002556 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1401659002557 oxidative stress defense protein; Provisional; Region: PRK11087 1401659002558 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1401659002559 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659002560 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 1401659002561 putative dimerization interface [polypeptide binding]; other site 1401659002562 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1401659002563 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1401659002564 active site 1401659002565 dimer interface [polypeptide binding]; other site 1401659002566 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1401659002567 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1401659002568 ligand binding site [chemical binding]; other site 1401659002569 NAD binding site [chemical binding]; other site 1401659002570 tetramer interface [polypeptide binding]; other site 1401659002571 catalytic site [active] 1401659002572 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1401659002573 L-serine binding site [chemical binding]; other site 1401659002574 ACT domain interface; other site 1401659002575 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 1401659002576 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1401659002577 hypothetical protein; Reviewed; Region: PRK01736 1401659002578 proline aminopeptidase P II; Provisional; Region: PRK10879 1401659002579 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1401659002580 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1401659002581 active site 1401659002582 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 1401659002583 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 1401659002584 oxidoreductase; Provisional; Region: PRK08013 1401659002585 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1401659002586 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1401659002587 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1401659002588 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1401659002589 lipoyl attachment site [posttranslational modification]; other site 1401659002590 glycine dehydrogenase; Provisional; Region: PRK05367 1401659002591 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1401659002592 tetramer interface [polypeptide binding]; other site 1401659002593 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659002594 catalytic residue [active] 1401659002595 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1401659002596 tetramer interface [polypeptide binding]; other site 1401659002597 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659002598 catalytic residue [active] 1401659002599 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 1401659002600 classical (c) SDRs; Region: SDR_c; cd05233 1401659002601 NAD(P) binding site [chemical binding]; other site 1401659002602 active site 1401659002603 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 1401659002604 beta-galactosidase; Region: BGL; TIGR03356 1401659002605 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1401659002606 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1401659002607 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1401659002608 putative active site [active] 1401659002609 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 1401659002610 hemolysin; Provisional; Region: PRK15087 1401659002611 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1401659002612 putative global regulator; Reviewed; Region: PRK09559 1401659002613 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1401659002614 hypothetical protein; Provisional; Region: PRK10878 1401659002615 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 1401659002616 flavodoxin FldB; Provisional; Region: PRK12359 1401659002617 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1401659002618 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1401659002619 active site 1401659002620 Int/Topo IB signature motif; other site 1401659002621 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 1401659002622 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1401659002623 dimerization domain [polypeptide binding]; other site 1401659002624 dimer interface [polypeptide binding]; other site 1401659002625 catalytic residues [active] 1401659002626 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1401659002627 DHH family; Region: DHH; pfam01368 1401659002628 DHHA1 domain; Region: DHHA1; pfam02272 1401659002629 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1401659002630 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1401659002631 RF-1 domain; Region: RF-1; pfam00472 1401659002632 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1401659002633 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1401659002634 dimer interface [polypeptide binding]; other site 1401659002635 putative anticodon binding site; other site 1401659002636 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1401659002637 motif 1; other site 1401659002638 active site 1401659002639 motif 2; other site 1401659002640 motif 3; other site 1401659002641 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1401659002642 Peptidase family M23; Region: Peptidase_M23; pfam01551 1401659002643 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1401659002644 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 1401659002645 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 1401659002646 ligand binding site [chemical binding]; other site 1401659002647 flexible hinge region; other site 1401659002648 Transcriptional regulator; Region: Rrf2; cl17282 1401659002649 putative acyltransferase; Provisional; Region: PRK05790 1401659002650 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1401659002651 dimer interface [polypeptide binding]; other site 1401659002652 active site 1401659002653 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 1401659002654 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1401659002655 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1401659002656 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 1401659002657 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1401659002658 NADP binding site [chemical binding]; other site 1401659002659 homodimer interface [polypeptide binding]; other site 1401659002660 active site 1401659002661 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1401659002662 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1401659002663 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1401659002664 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1401659002665 Walker A/P-loop; other site 1401659002666 ATP binding site [chemical binding]; other site 1401659002667 Q-loop/lid; other site 1401659002668 ABC transporter signature motif; other site 1401659002669 Walker B; other site 1401659002670 D-loop; other site 1401659002671 H-loop/switch region; other site 1401659002672 TOBE domain; Region: TOBE; pfam03459 1401659002673 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1401659002674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659002675 dimer interface [polypeptide binding]; other site 1401659002676 conserved gate region; other site 1401659002677 putative PBP binding loops; other site 1401659002678 ABC-ATPase subunit interface; other site 1401659002679 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659002680 dimer interface [polypeptide binding]; other site 1401659002681 conserved gate region; other site 1401659002682 putative PBP binding loops; other site 1401659002683 ABC-ATPase subunit interface; other site 1401659002684 LPS O-antigen length regulator; Provisional; Region: PRK10381 1401659002685 Chain length determinant protein; Region: Wzz; pfam02706 1401659002686 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1401659002687 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1401659002688 aspartate racemase; Region: asp_race; TIGR00035 1401659002689 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1401659002690 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1401659002691 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659002692 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1401659002693 dimerization interface [polypeptide binding]; other site 1401659002694 diaminopimelate decarboxylase; Provisional; Region: PRK11165 1401659002695 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1401659002696 active site 1401659002697 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1401659002698 substrate binding site [chemical binding]; other site 1401659002699 catalytic residues [active] 1401659002700 dimer interface [polypeptide binding]; other site 1401659002701 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1401659002702 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1401659002703 DNA binding site [nucleotide binding] 1401659002704 domain linker motif; other site 1401659002705 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1401659002706 dimerization interface (closed form) [polypeptide binding]; other site 1401659002707 ligand binding site [chemical binding]; other site 1401659002708 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1401659002709 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1401659002710 beta-galactosidase; Region: BGL; TIGR03356 1401659002711 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1401659002712 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1401659002713 active site 1401659002714 P-loop; other site 1401659002715 phosphorylation site [posttranslational modification] 1401659002716 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 1401659002717 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1401659002718 DNA-binding site [nucleotide binding]; DNA binding site 1401659002719 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1401659002720 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1401659002721 Coenzyme A binding pocket [chemical binding]; other site 1401659002722 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 1401659002723 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1401659002724 DNA binding site [nucleotide binding] 1401659002725 domain linker motif; other site 1401659002726 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1401659002727 dimerization interface (closed form) [polypeptide binding]; other site 1401659002728 ligand binding site [chemical binding]; other site 1401659002729 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 1401659002730 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1401659002731 putative acyl-acceptor binding pocket; other site 1401659002732 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 1401659002733 acyl-activating enzyme (AAE) consensus motif; other site 1401659002734 putative AMP binding site [chemical binding]; other site 1401659002735 lysophospholipid transporter LplT; Provisional; Region: PRK11195 1401659002736 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659002737 putative substrate translocation pore; other site 1401659002738 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1401659002739 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1401659002740 active site 1401659002741 catalytic tetrad [active] 1401659002742 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1401659002743 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1401659002744 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 1401659002745 putative DNA-binding cleft [nucleotide binding]; other site 1401659002746 putative DNA clevage site; other site 1401659002747 molecular lever; other site 1401659002748 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1401659002749 putative active site [active] 1401659002750 Ap4A binding site [chemical binding]; other site 1401659002751 nudix motif; other site 1401659002752 putative metal binding site [ion binding]; other site 1401659002753 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 1401659002754 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1401659002755 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1401659002756 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1401659002757 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1401659002758 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1401659002759 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1401659002760 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1401659002761 dimerization interface [polypeptide binding]; other site 1401659002762 active site 1401659002763 hypothetical protein; Provisional; Region: PRK10506 1401659002764 hypothetical protein; Provisional; Region: PRK10557 1401659002765 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1401659002766 Protein of unknown function (DUF2509); Region: DUF2509; pfam10713 1401659002767 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 1401659002768 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1401659002769 protease3; Provisional; Region: PRK15101 1401659002770 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1401659002771 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1401659002772 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1401659002773 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 1401659002774 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1401659002775 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 1401659002776 AAA domain; Region: AAA_30; pfam13604 1401659002777 Family description; Region: UvrD_C_2; pfam13538 1401659002778 N-acetylglutamate synthase; Validated; Region: PRK05279 1401659002779 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1401659002780 putative nucleotide binding site [chemical binding]; other site 1401659002781 putative substrate binding site [chemical binding]; other site 1401659002782 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1401659002783 Coenzyme A binding pocket [chemical binding]; other site 1401659002784 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 1401659002785 AMIN domain; Region: AMIN; pfam11741 1401659002786 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1401659002787 active site 1401659002788 metal binding site [ion binding]; metal-binding site 1401659002789 murein transglycosylase A; Provisional; Region: mltA; PRK11162 1401659002790 MltA specific insert domain; Region: MltA; smart00925 1401659002791 3D domain; Region: 3D; pfam06725 1401659002792 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 1401659002793 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1401659002794 putative ATP binding site [chemical binding]; other site 1401659002795 putative substrate interface [chemical binding]; other site 1401659002796 Fe-S metabolism associated domain; Region: SufE; cl00951 1401659002797 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1401659002798 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1401659002799 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1401659002800 catalytic residue [active] 1401659002801 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1401659002802 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1401659002803 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659002804 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1401659002805 dimerization interface [polypeptide binding]; other site 1401659002806 substrate binding pocket [chemical binding]; other site 1401659002807 hypothetical protein; Provisional; Region: PRK10873 1401659002808 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 1401659002809 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1401659002810 flap endonuclease-like protein; Provisional; Region: PRK09482 1401659002811 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1401659002812 active site 1401659002813 metal binding site 1 [ion binding]; metal-binding site 1401659002814 putative 5' ssDNA interaction site; other site 1401659002815 metal binding site 3; metal-binding site 1401659002816 metal binding site 2 [ion binding]; metal-binding site 1401659002817 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1401659002818 putative DNA binding site [nucleotide binding]; other site 1401659002819 putative metal binding site [ion binding]; other site 1401659002820 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1401659002821 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1401659002822 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1401659002823 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1401659002824 serine transporter; Region: stp; TIGR00814 1401659002825 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1401659002826 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 1401659002827 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 1401659002828 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 1401659002829 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1401659002830 SecY interacting protein Syd; Provisional; Region: PRK04968 1401659002831 tRNA pseudouridine synthase C; Region: DUF446; cl01187 1401659002832 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1401659002833 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 1401659002834 probable active site [active] 1401659002835 flavodoxin; Provisional; Region: PRK08105 1401659002836 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 1401659002837 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 1401659002838 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1401659002839 dimerization interface [polypeptide binding]; other site 1401659002840 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1401659002841 dimer interface [polypeptide binding]; other site 1401659002842 phosphorylation site [posttranslational modification] 1401659002843 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1401659002844 ATP binding site [chemical binding]; other site 1401659002845 Mg2+ binding site [ion binding]; other site 1401659002846 G-X-G motif; other site 1401659002847 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 1401659002848 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1401659002849 active site 1401659002850 phosphorylation site [posttranslational modification] 1401659002851 intermolecular recognition site; other site 1401659002852 dimerization interface [polypeptide binding]; other site 1401659002853 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1401659002854 putative binding surface; other site 1401659002855 active site 1401659002856 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1401659002857 TRAM domain; Region: TRAM; pfam01938 1401659002858 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1401659002859 S-adenosylmethionine binding site [chemical binding]; other site 1401659002860 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 1401659002861 HD domain; Region: HD_4; pfam13328 1401659002862 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1401659002863 synthetase active site [active] 1401659002864 NTP binding site [chemical binding]; other site 1401659002865 metal binding site [ion binding]; metal-binding site 1401659002866 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1401659002867 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1401659002868 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1401659002869 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1401659002870 homodimer interface [polypeptide binding]; other site 1401659002871 metal binding site [ion binding]; metal-binding site 1401659002872 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1401659002873 homodimer interface [polypeptide binding]; other site 1401659002874 active site 1401659002875 putative chemical substrate binding site [chemical binding]; other site 1401659002876 metal binding site [ion binding]; metal-binding site 1401659002877 CTP synthetase; Validated; Region: pyrG; PRK05380 1401659002878 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1401659002879 Catalytic site [active] 1401659002880 active site 1401659002881 UTP binding site [chemical binding]; other site 1401659002882 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1401659002883 active site 1401659002884 putative oxyanion hole; other site 1401659002885 catalytic triad [active] 1401659002886 enolase; Provisional; Region: eno; PRK00077 1401659002887 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1401659002888 dimer interface [polypeptide binding]; other site 1401659002889 metal binding site [ion binding]; metal-binding site 1401659002890 substrate binding pocket [chemical binding]; other site 1401659002891 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1401659002892 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1401659002893 NAD(P) binding site [chemical binding]; other site 1401659002894 active site 1401659002895 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1401659002896 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1401659002897 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1401659002898 putative active site [active] 1401659002899 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1401659002900 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1401659002901 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1401659002902 active site turn [active] 1401659002903 phosphorylation site [posttranslational modification] 1401659002904 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1401659002905 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1401659002906 putative active site cavity [active] 1401659002907 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1401659002908 Repair protein; Region: Repair_PSII; pfam04536 1401659002909 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1401659002910 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1401659002911 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1401659002912 active site 1401659002913 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 1401659002914 Flavodoxin; Region: Flavodoxin_1; pfam00258 1401659002915 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1401659002916 FAD binding pocket [chemical binding]; other site 1401659002917 FAD binding motif [chemical binding]; other site 1401659002918 catalytic residues [active] 1401659002919 NAD binding pocket [chemical binding]; other site 1401659002920 phosphate binding motif [ion binding]; other site 1401659002921 beta-alpha-beta structure motif; other site 1401659002922 sulfite reductase subunit beta; Provisional; Region: PRK13504 1401659002923 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1401659002924 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1401659002925 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1401659002926 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1401659002927 Active Sites [active] 1401659002928 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 1401659002929 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1401659002930 metal binding site [ion binding]; metal-binding site 1401659002931 siroheme synthase; Provisional; Region: cysG; PRK10637 1401659002932 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1401659002933 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1401659002934 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1401659002935 active site 1401659002936 SAM binding site [chemical binding]; other site 1401659002937 homodimer interface [polypeptide binding]; other site 1401659002938 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1401659002939 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1401659002940 Active Sites [active] 1401659002941 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 1401659002942 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1401659002943 CysD dimerization site [polypeptide binding]; other site 1401659002944 G1 box; other site 1401659002945 putative GEF interaction site [polypeptide binding]; other site 1401659002946 GTP/Mg2+ binding site [chemical binding]; other site 1401659002947 Switch I region; other site 1401659002948 G2 box; other site 1401659002949 G3 box; other site 1401659002950 Switch II region; other site 1401659002951 G4 box; other site 1401659002952 G5 box; other site 1401659002953 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1401659002954 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1401659002955 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1401659002956 ligand-binding site [chemical binding]; other site 1401659002957 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 1401659002958 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 1401659002959 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1401659002960 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1401659002961 substrate binding site; other site 1401659002962 dimer interface; other site 1401659002963 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1401659002964 homotrimer interaction site [polypeptide binding]; other site 1401659002965 zinc binding site [ion binding]; other site 1401659002966 CDP-binding sites; other site 1401659002967 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 1401659002968 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 1401659002969 Permutation of conserved domain; other site 1401659002970 active site 1401659002971 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1401659002972 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1401659002973 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1401659002974 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1401659002975 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1401659002976 S-adenosylmethionine binding site [chemical binding]; other site 1401659002977 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1401659002978 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1401659002979 Peptidase family M23; Region: Peptidase_M23; pfam01551 1401659002980 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 1401659002981 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1401659002982 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1401659002983 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1401659002984 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1401659002985 DNA binding residues [nucleotide binding] 1401659002986 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 1401659002987 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659002988 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1401659002989 putative substrate translocation pore; other site 1401659002990 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1401659002991 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659002992 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1401659002993 putative effector binding pocket; other site 1401659002994 dimerization interface [polypeptide binding]; other site 1401659002995 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1401659002996 MarR family; Region: MarR_2; cl17246 1401659002997 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 1401659002998 Flavoprotein; Region: Flavoprotein; pfam02441 1401659002999 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 1401659003000 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1401659003001 MutS domain I; Region: MutS_I; pfam01624 1401659003002 MutS domain II; Region: MutS_II; pfam05188 1401659003003 MutS domain III; Region: MutS_III; pfam05192 1401659003004 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1401659003005 Walker A/P-loop; other site 1401659003006 ATP binding site [chemical binding]; other site 1401659003007 Q-loop/lid; other site 1401659003008 ABC transporter signature motif; other site 1401659003009 Walker B; other site 1401659003010 D-loop; other site 1401659003011 H-loop/switch region; other site 1401659003012 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1401659003013 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1401659003014 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1401659003015 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1401659003016 dimer interface [polypeptide binding]; other site 1401659003017 ligand binding site [chemical binding]; other site 1401659003018 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1401659003019 dimerization interface [polypeptide binding]; other site 1401659003020 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1401659003021 dimer interface [polypeptide binding]; other site 1401659003022 putative CheW interface [polypeptide binding]; other site 1401659003023 KTSC domain; Region: KTSC; pfam13619 1401659003024 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1401659003025 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1401659003026 substrate binding pocket [chemical binding]; other site 1401659003027 membrane-bound complex binding site; other site 1401659003028 hinge residues; other site 1401659003029 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1401659003030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659003031 dimer interface [polypeptide binding]; other site 1401659003032 conserved gate region; other site 1401659003033 putative PBP binding loops; other site 1401659003034 ABC-ATPase subunit interface; other site 1401659003035 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1401659003036 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1401659003037 Walker A/P-loop; other site 1401659003038 ATP binding site [chemical binding]; other site 1401659003039 Q-loop/lid; other site 1401659003040 ABC transporter signature motif; other site 1401659003041 Walker B; other site 1401659003042 D-loop; other site 1401659003043 H-loop/switch region; other site 1401659003044 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1401659003045 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1401659003046 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1401659003047 hypothetical protein; Validated; Region: PRK03661 1401659003048 recombinase A; Provisional; Region: recA; PRK09354 1401659003049 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1401659003050 hexamer interface [polypeptide binding]; other site 1401659003051 Walker A motif; other site 1401659003052 ATP binding site [chemical binding]; other site 1401659003053 Walker B motif; other site 1401659003054 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1401659003055 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1401659003056 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1401659003057 active site 1401659003058 motif 2; other site 1401659003059 motif 3; other site 1401659003060 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1401659003061 DHHA1 domain; Region: DHHA1; pfam02272 1401659003062 carbon storage regulator; Provisional; Region: PRK01712 1401659003063 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 1401659003064 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1401659003065 motif II; other site 1401659003066 Predicted membrane protein [Function unknown]; Region: COG1238 1401659003067 glutamate--cysteine ligase; Provisional; Region: PRK02107 1401659003068 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1401659003069 CHASE4 domain; Region: CHASE4; pfam05228 1401659003070 PAS domain S-box; Region: sensory_box; TIGR00229 1401659003071 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1401659003072 putative active site [active] 1401659003073 heme pocket [chemical binding]; other site 1401659003074 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1401659003075 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1401659003076 metal binding site [ion binding]; metal-binding site 1401659003077 active site 1401659003078 I-site; other site 1401659003079 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1401659003080 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1401659003081 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659003082 putative substrate translocation pore; other site 1401659003083 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659003084 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 1401659003085 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1401659003086 HlyD family secretion protein; Region: HlyD_3; pfam13437 1401659003087 transcriptional repressor MprA; Provisional; Region: PRK10870 1401659003088 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1401659003089 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1401659003090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659003091 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 1401659003092 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1401659003093 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1401659003094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659003095 dimer interface [polypeptide binding]; other site 1401659003096 conserved gate region; other site 1401659003097 putative PBP binding loops; other site 1401659003098 ABC-ATPase subunit interface; other site 1401659003099 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 1401659003100 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1401659003101 Walker A/P-loop; other site 1401659003102 ATP binding site [chemical binding]; other site 1401659003103 Q-loop/lid; other site 1401659003104 ABC transporter signature motif; other site 1401659003105 Walker B; other site 1401659003106 D-loop; other site 1401659003107 H-loop/switch region; other site 1401659003108 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1401659003109 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1401659003110 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1401659003111 dimer interface [polypeptide binding]; other site 1401659003112 putative radical transfer pathway; other site 1401659003113 diiron center [ion binding]; other site 1401659003114 tyrosyl radical; other site 1401659003115 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1401659003116 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1401659003117 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1401659003118 active site 1401659003119 dimer interface [polypeptide binding]; other site 1401659003120 catalytic residues [active] 1401659003121 effector binding site; other site 1401659003122 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1401659003123 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1401659003124 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1401659003125 catalytic residues [active] 1401659003126 hypothetical protein; Provisional; Region: PRK10132 1401659003127 hypothetical protein; Provisional; Region: PRK10556 1401659003128 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 1401659003129 SAM (Sterile alpha motif ); Region: SAM_superfamily; cl15755 1401659003130 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 1401659003131 FIST N domain; Region: FIST; smart00897 1401659003132 FIST C domain; Region: FIST_C; pfam10442 1401659003133 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1401659003134 dimer interface [polypeptide binding]; other site 1401659003135 putative CheW interface [polypeptide binding]; other site 1401659003136 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1401659003137 active site 1401659003138 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1401659003139 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 1401659003140 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1401659003141 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1401659003142 active site 1401659003143 Int/Topo IB signature motif; other site 1401659003144 integrase; Provisional; Region: int; PHA02601 1401659003145 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1401659003146 Phage HP1 integrase, C-terminal catalytic domain. Bacteriophage HP1 and related integrases are found in eubacteria, plasmids and temperate bacteriophages of the P2 family. They belong to the DNA breaking-rejoining enzyme superfamily, which includes...; Region: HP1_INT_C; cd00797 1401659003147 dimer interface [polypeptide binding]; other site 1401659003148 active site 1401659003149 catalytic residues [active] 1401659003150 Int/Topo IB signature motif; other site 1401659003151 Predicted transcriptional regulator [Transcription]; Region: COG2932 1401659003152 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 1401659003153 Protein of unknown function (DUF2724); Region: DUF2724; pfam10893 1401659003154 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 1401659003155 DksA-like zinc finger domain containing protein; Region: PHA00080 1401659003156 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 1401659003157 portal vertex protein; Provisional; Region: Q; PHA02536 1401659003158 Phage portal protein; Region: Phage_portal; pfam04860 1401659003159 terminase ATPase subunit; Provisional; Region: P; PHA02535 1401659003160 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 1401659003161 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929 1401659003162 Phage major capsid protein, P2 family; Region: Phage_cap_P2; pfam05125 1401659003163 terminase endonuclease subunit; Provisional; Region: M; PHA02537 1401659003164 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 1401659003165 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 1401659003166 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 1401659003167 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1401659003168 catalytic residues [active] 1401659003169 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 1401659003170 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 1401659003171 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 1401659003172 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 1401659003173 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 1401659003174 Phage Tail Collar Domain; Region: Collar; pfam07484 1401659003175 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1401659003176 major tail sheath protein; Provisional; Region: FI; PHA02560 1401659003177 major tail tube protein; Provisional; Region: FII; PHA02600 1401659003178 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1401659003179 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1401659003180 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 1401659003181 tail protein; Provisional; Region: D; PHA02561 1401659003182 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25); Region: Herpes_pp85; pfam04637 1401659003183 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1401659003184 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1401659003185 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1401659003186 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1401659003187 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1401659003188 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1401659003189 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1401659003190 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1401659003191 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1401659003192 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1401659003193 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1401659003194 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1401659003195 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1401659003196 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1401659003197 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1401659003198 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1401659003199 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1401659003200 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1401659003201 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1401659003202 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 1401659003203 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1401659003204 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 1401659003205 Walker A/P-loop; other site 1401659003206 ATP binding site [chemical binding]; other site 1401659003207 Q-loop/lid; other site 1401659003208 ABC transporter signature motif; other site 1401659003209 Walker B; other site 1401659003210 D-loop; other site 1401659003211 H-loop/switch region; other site 1401659003212 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1401659003213 HlyD family secretion protein; Region: HlyD_3; pfam13437 1401659003214 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1401659003215 SmpB-tmRNA interface; other site 1401659003216 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1401659003217 putative coenzyme Q binding site [chemical binding]; other site 1401659003218 hypothetical protein; Validated; Region: PRK01777 1401659003219 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 1401659003220 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1401659003221 recombination and repair protein; Provisional; Region: PRK10869 1401659003222 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1401659003223 Walker A/P-loop; other site 1401659003224 ATP binding site [chemical binding]; other site 1401659003225 Q-loop/lid; other site 1401659003226 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1401659003227 Q-loop/lid; other site 1401659003228 ABC transporter signature motif; other site 1401659003229 Walker B; other site 1401659003230 D-loop; other site 1401659003231 H-loop/switch region; other site 1401659003232 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 1401659003233 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1401659003234 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1401659003235 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1401659003236 dimer interface [polypeptide binding]; other site 1401659003237 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1401659003238 hypothetical protein; Provisional; Region: PRK11573 1401659003239 Domain of unknown function DUF21; Region: DUF21; pfam01595 1401659003240 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1401659003241 Transporter associated domain; Region: CorC_HlyC; smart01091 1401659003242 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 1401659003243 signal recognition particle protein; Provisional; Region: PRK10867 1401659003244 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1401659003245 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1401659003246 P loop; other site 1401659003247 GTP binding site [chemical binding]; other site 1401659003248 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1401659003249 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1401659003250 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1401659003251 RimM N-terminal domain; Region: RimM; pfam01782 1401659003252 PRC-barrel domain; Region: PRC; pfam05239 1401659003253 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1401659003254 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1401659003255 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1401659003256 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1401659003257 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1401659003258 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1401659003259 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 1401659003260 Chorismate mutase type II; Region: CM_2; cl00693 1401659003261 prephenate dehydrogenase; Validated; Region: PRK08507 1401659003262 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1401659003263 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 1401659003264 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 1401659003265 Prephenate dehydratase; Region: PDT; pfam00800 1401659003266 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1401659003267 putative L-Phe binding site [chemical binding]; other site 1401659003268 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1401659003269 30S subunit binding site; other site 1401659003270 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1401659003271 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 1401659003272 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1401659003273 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1401659003274 RNA binding surface [nucleotide binding]; other site 1401659003275 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1401659003276 active site 1401659003277 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1401659003278 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1401659003279 protein disaggregation chaperone; Provisional; Region: PRK10865 1401659003280 Clp amino terminal domain; Region: Clp_N; pfam02861 1401659003281 Clp amino terminal domain; Region: Clp_N; pfam02861 1401659003282 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1401659003283 Walker A motif; other site 1401659003284 ATP binding site [chemical binding]; other site 1401659003285 Walker B motif; other site 1401659003286 arginine finger; other site 1401659003287 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1401659003288 Walker A motif; other site 1401659003289 ATP binding site [chemical binding]; other site 1401659003290 Walker B motif; other site 1401659003291 arginine finger; other site 1401659003292 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1401659003293 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1401659003294 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1401659003295 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1401659003296 non-specific DNA binding site [nucleotide binding]; other site 1401659003297 salt bridge; other site 1401659003298 sequence-specific DNA binding site [nucleotide binding]; other site 1401659003299 2TM domain; Region: 2TM; pfam13239 1401659003300 thiamine pyrophosphate protein; Provisional; Region: PRK08273 1401659003301 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1401659003302 PYR/PP interface [polypeptide binding]; other site 1401659003303 dimer interface [polypeptide binding]; other site 1401659003304 tetramer interface [polypeptide binding]; other site 1401659003305 TPP binding site [chemical binding]; other site 1401659003306 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1401659003307 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1401659003308 TPP-binding site [chemical binding]; other site 1401659003309 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 1401659003310 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1401659003311 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659003312 putative substrate translocation pore; other site 1401659003313 lipoprotein; Provisional; Region: PRK10759 1401659003314 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 1401659003315 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 1401659003316 domain interface [polypeptide binding]; other site 1401659003317 putative active site [active] 1401659003318 catalytic site [active] 1401659003319 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 1401659003320 domain interface [polypeptide binding]; other site 1401659003321 putative active site [active] 1401659003322 catalytic site [active] 1401659003323 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1401659003324 CoA binding domain; Region: CoA_binding_2; pfam13380 1401659003325 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1401659003326 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1401659003327 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1401659003328 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1401659003329 Uncharacterized conserved protein [Function unknown]; Region: COG3148 1401659003330 thioredoxin 2; Provisional; Region: PRK10996 1401659003331 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1401659003332 catalytic residues [active] 1401659003333 putative methyltransferase; Provisional; Region: PRK10864 1401659003334 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1401659003335 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1401659003336 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1401659003337 ligand binding site [chemical binding]; other site 1401659003338 active site 1401659003339 UGI interface [polypeptide binding]; other site 1401659003340 catalytic site [active] 1401659003341 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 1401659003342 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1401659003343 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1401659003344 ATP binding site [chemical binding]; other site 1401659003345 Mg++ binding site [ion binding]; other site 1401659003346 motif III; other site 1401659003347 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1401659003348 nucleotide binding region [chemical binding]; other site 1401659003349 ATP-binding site [chemical binding]; other site 1401659003350 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1401659003351 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1401659003352 S-adenosylmethionine binding site [chemical binding]; other site 1401659003353 L-aspartate oxidase; Provisional; Region: PRK09077 1401659003354 L-aspartate oxidase; Provisional; Region: PRK06175 1401659003355 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1401659003356 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 1401659003357 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1401659003358 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1401659003359 DNA binding residues [nucleotide binding] 1401659003360 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 1401659003361 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 1401659003362 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 1401659003363 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 1401659003364 anti-sigma E factor; Provisional; Region: rseB; PRK09455 1401659003365 SoxR reducing system protein RseC; Provisional; Region: PRK10862 1401659003366 GTP-binding protein LepA; Provisional; Region: PRK05433 1401659003367 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1401659003368 G1 box; other site 1401659003369 putative GEF interaction site [polypeptide binding]; other site 1401659003370 GTP/Mg2+ binding site [chemical binding]; other site 1401659003371 Switch I region; other site 1401659003372 G2 box; other site 1401659003373 G3 box; other site 1401659003374 Switch II region; other site 1401659003375 G4 box; other site 1401659003376 G5 box; other site 1401659003377 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1401659003378 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1401659003379 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1401659003380 signal peptidase I; Provisional; Region: PRK10861 1401659003381 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1401659003382 Catalytic site [active] 1401659003383 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1401659003384 ribonuclease III; Reviewed; Region: rnc; PRK00102 1401659003385 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1401659003386 dimerization interface [polypeptide binding]; other site 1401659003387 active site 1401659003388 metal binding site [ion binding]; metal-binding site 1401659003389 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1401659003390 dsRNA binding site [nucleotide binding]; other site 1401659003391 GTPase Era; Reviewed; Region: era; PRK00089 1401659003392 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1401659003393 G1 box; other site 1401659003394 GTP/Mg2+ binding site [chemical binding]; other site 1401659003395 Switch I region; other site 1401659003396 G2 box; other site 1401659003397 Switch II region; other site 1401659003398 G3 box; other site 1401659003399 G4 box; other site 1401659003400 G5 box; other site 1401659003401 KH domain; Region: KH_2; pfam07650 1401659003402 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1401659003403 Recombination protein O N terminal; Region: RecO_N; pfam11967 1401659003404 Recombination protein O C terminal; Region: RecO_C; pfam02565 1401659003405 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1401659003406 active site 1401659003407 hydrophilic channel; other site 1401659003408 dimerization interface [polypeptide binding]; other site 1401659003409 catalytic residues [active] 1401659003410 active site lid [active] 1401659003411 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1401659003412 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1401659003413 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1401659003414 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 1401659003415 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1401659003416 putative active site [active] 1401659003417 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1401659003418 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1401659003419 putative active site [active] 1401659003420 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1401659003421 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1401659003422 active site turn [active] 1401659003423 phosphorylation site [posttranslational modification] 1401659003424 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1401659003425 hypothetical protein; Provisional; Region: PRK11590 1401659003426 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1401659003427 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 1401659003428 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1401659003429 substrate binding pocket [chemical binding]; other site 1401659003430 membrane-bound complex binding site; other site 1401659003431 hinge residues; other site 1401659003432 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1401659003433 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1401659003434 catalytic residue [active] 1401659003435 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1401659003436 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1401659003437 dimerization interface [polypeptide binding]; other site 1401659003438 ATP binding site [chemical binding]; other site 1401659003439 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1401659003440 dimerization interface [polypeptide binding]; other site 1401659003441 ATP binding site [chemical binding]; other site 1401659003442 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1401659003443 putative active site [active] 1401659003444 catalytic triad [active] 1401659003445 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1401659003446 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1401659003447 dimer interface [polypeptide binding]; other site 1401659003448 phosphorylation site [posttranslational modification] 1401659003449 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1401659003450 ATP binding site [chemical binding]; other site 1401659003451 Mg2+ binding site [ion binding]; other site 1401659003452 G-X-G motif; other site 1401659003453 hypothetical protein; Provisional; Region: PRK10722 1401659003454 response regulator GlrR; Provisional; Region: PRK15115 1401659003455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1401659003456 active site 1401659003457 phosphorylation site [posttranslational modification] 1401659003458 intermolecular recognition site; other site 1401659003459 dimerization interface [polypeptide binding]; other site 1401659003460 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1401659003461 Walker A motif; other site 1401659003462 ATP binding site [chemical binding]; other site 1401659003463 Walker B motif; other site 1401659003464 arginine finger; other site 1401659003465 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 1401659003466 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1401659003467 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1401659003468 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1401659003469 heme-binding site [chemical binding]; other site 1401659003470 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1401659003471 FAD binding pocket [chemical binding]; other site 1401659003472 FAD binding motif [chemical binding]; other site 1401659003473 phosphate binding motif [ion binding]; other site 1401659003474 beta-alpha-beta structure motif; other site 1401659003475 NAD binding pocket [chemical binding]; other site 1401659003476 Heme binding pocket [chemical binding]; other site 1401659003477 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1401659003478 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1401659003479 dimer interface [polypeptide binding]; other site 1401659003480 active site 1401659003481 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1401659003482 folate binding site [chemical binding]; other site 1401659003483 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1401659003484 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1401659003485 DNA binding residues [nucleotide binding] 1401659003486 putative dimer interface [polypeptide binding]; other site 1401659003487 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1401659003488 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1401659003489 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659003490 putative substrate translocation pore; other site 1401659003491 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 1401659003492 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 1401659003493 PRD domain; Region: PRD; pfam00874 1401659003494 PRD domain; Region: PRD; pfam00874 1401659003495 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 1401659003496 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 1401659003497 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1401659003498 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1401659003499 active site 1401659003500 dimerization interface [polypeptide binding]; other site 1401659003501 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 1401659003502 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1401659003503 Transcriptional regulator; Region: Rrf2; cl17282 1401659003504 Rrf2 family protein; Region: rrf2_super; TIGR00738 1401659003505 cysteine desulfurase; Provisional; Region: PRK14012 1401659003506 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1401659003507 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1401659003508 catalytic residue [active] 1401659003509 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1401659003510 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1401659003511 trimerization site [polypeptide binding]; other site 1401659003512 active site 1401659003513 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 1401659003514 co-chaperone HscB; Provisional; Region: hscB; PRK05014 1401659003515 DnaJ domain; Region: DnaJ; pfam00226 1401659003516 HSP70 interaction site [polypeptide binding]; other site 1401659003517 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 1401659003518 chaperone protein HscA; Provisional; Region: hscA; PRK05183 1401659003519 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 1401659003520 nucleotide binding site [chemical binding]; other site 1401659003521 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1401659003522 SBD interface [polypeptide binding]; other site 1401659003523 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1401659003524 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1401659003525 catalytic loop [active] 1401659003526 iron binding site [ion binding]; other site 1401659003527 hypothetical protein; Provisional; Region: PRK10721 1401659003528 aminopeptidase B; Provisional; Region: PRK05015 1401659003529 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1401659003530 interface (dimer of trimers) [polypeptide binding]; other site 1401659003531 Substrate-binding/catalytic site; other site 1401659003532 Zn-binding sites [ion binding]; other site 1401659003533 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 1401659003534 Peptidase family M48; Region: Peptidase_M48; cl12018 1401659003535 Peptidase family M48; Region: Peptidase_M48; cl12018 1401659003536 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1401659003537 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1401659003538 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1401659003539 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1401659003540 putative active site [active] 1401659003541 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 1401659003542 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1401659003543 active site residue [active] 1401659003544 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1401659003545 active site residue [active] 1401659003546 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1401659003547 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 1401659003548 NAD binding site [chemical binding]; other site 1401659003549 sugar binding site [chemical binding]; other site 1401659003550 divalent metal binding site [ion binding]; other site 1401659003551 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1401659003552 dimer interface [polypeptide binding]; other site 1401659003553 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1401659003554 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1401659003555 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1401659003556 active site turn [active] 1401659003557 phosphorylation site [posttranslational modification] 1401659003558 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1401659003559 MG2 domain; Region: A2M_N; pfam01835 1401659003560 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1401659003561 surface patch; other site 1401659003562 thioester region; other site 1401659003563 penicillin-binding protein 1C; Provisional; Region: PRK11240 1401659003564 Transglycosylase; Region: Transgly; pfam00912 1401659003565 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1401659003566 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 1401659003567 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1401659003568 active site 1401659003569 multimer interface [polypeptide binding]; other site 1401659003570 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1401659003571 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1401659003572 FeS/SAM binding site; other site 1401659003573 cytoskeletal protein RodZ; Provisional; Region: PRK10856 1401659003574 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1401659003575 non-specific DNA binding site [nucleotide binding]; other site 1401659003576 salt bridge; other site 1401659003577 sequence-specific DNA binding site [nucleotide binding]; other site 1401659003578 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1401659003579 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1401659003580 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1401659003581 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1401659003582 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1401659003583 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1401659003584 dimer interface [polypeptide binding]; other site 1401659003585 motif 1; other site 1401659003586 active site 1401659003587 motif 2; other site 1401659003588 motif 3; other site 1401659003589 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1401659003590 anticodon binding site; other site 1401659003591 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1401659003592 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 1401659003593 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 1401659003594 Trp docking motif [polypeptide binding]; other site 1401659003595 GTP-binding protein Der; Reviewed; Region: PRK00093 1401659003596 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1401659003597 G1 box; other site 1401659003598 GTP/Mg2+ binding site [chemical binding]; other site 1401659003599 Switch I region; other site 1401659003600 G2 box; other site 1401659003601 Switch II region; other site 1401659003602 G3 box; other site 1401659003603 G4 box; other site 1401659003604 G5 box; other site 1401659003605 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1401659003606 G1 box; other site 1401659003607 GTP/Mg2+ binding site [chemical binding]; other site 1401659003608 Switch I region; other site 1401659003609 G2 box; other site 1401659003610 G3 box; other site 1401659003611 Switch II region; other site 1401659003612 G4 box; other site 1401659003613 G5 box; other site 1401659003614 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 1401659003615 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 1401659003616 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1401659003617 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1401659003618 active site 1401659003619 Zn binding site [ion binding]; other site 1401659003620 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1401659003621 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1401659003622 generic binding surface II; other site 1401659003623 generic binding surface I; other site 1401659003624 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1401659003625 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1401659003626 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1401659003627 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1401659003628 active site 1401659003629 GMP synthase; Reviewed; Region: guaA; PRK00074 1401659003630 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1401659003631 AMP/PPi binding site [chemical binding]; other site 1401659003632 candidate oxyanion hole; other site 1401659003633 catalytic triad [active] 1401659003634 potential glutamine specificity residues [chemical binding]; other site 1401659003635 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1401659003636 ATP Binding subdomain [chemical binding]; other site 1401659003637 Ligand Binding sites [chemical binding]; other site 1401659003638 Dimerization subdomain; other site 1401659003639 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 1401659003640 MASE1; Region: MASE1; pfam05231 1401659003641 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1401659003642 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1401659003643 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1401659003644 exopolyphosphatase; Provisional; Region: PRK10854 1401659003645 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1401659003646 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 1401659003647 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1401659003648 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1401659003649 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1401659003650 putative active site [active] 1401659003651 catalytic site [active] 1401659003652 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 1401659003653 domain interface [polypeptide binding]; other site 1401659003654 active site 1401659003655 catalytic site [active] 1401659003656 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1401659003657 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1401659003658 active site 1401659003659 substrate binding site [chemical binding]; other site 1401659003660 cosubstrate binding site; other site 1401659003661 catalytic site [active] 1401659003662 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1401659003663 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1401659003664 dimerization interface [polypeptide binding]; other site 1401659003665 putative ATP binding site [chemical binding]; other site 1401659003666 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1401659003667 active site 1401659003668 uracil transporter; Provisional; Region: PRK10720 1401659003669 DNA replication initiation factor; Provisional; Region: PRK08084 1401659003670 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1401659003671 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1401659003672 ArsC family; Region: ArsC; pfam03960 1401659003673 catalytic residues [active] 1401659003674 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1401659003675 Peptidase family M48; Region: Peptidase_M48; cl12018 1401659003676 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1401659003677 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1401659003678 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1401659003679 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1401659003680 catalytic triad [active] 1401659003681 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 1401659003682 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 1401659003683 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1401659003684 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1401659003685 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1401659003686 dimer interface [polypeptide binding]; other site 1401659003687 active site 1401659003688 catalytic residue [active] 1401659003689 lipoprotein; Provisional; Region: PRK11679 1401659003690 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 1401659003691 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1401659003692 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1401659003693 active site 1401659003694 ATP binding site [chemical binding]; other site 1401659003695 substrate binding site [chemical binding]; other site 1401659003696 Predicted metalloprotease [General function prediction only]; Region: COG2321 1401659003697 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1401659003698 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 1401659003699 Helicase; Region: Helicase_RecD; pfam05127 1401659003700 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1401659003701 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 1401659003702 putative hydrolase; Provisional; Region: PRK11460 1401659003703 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1401659003704 hypothetical protein; Provisional; Region: PRK13664 1401659003705 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1401659003706 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1401659003707 metal binding site [ion binding]; metal-binding site 1401659003708 dimer interface [polypeptide binding]; other site 1401659003709 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1401659003710 ArsC family; Region: ArsC; pfam03960 1401659003711 putative catalytic residues [active] 1401659003712 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1401659003713 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1401659003714 Coenzyme A binding pocket [chemical binding]; other site 1401659003715 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 1401659003716 Protein export membrane protein; Region: SecD_SecF; cl14618 1401659003717 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 1401659003718 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1401659003719 dimer interface [polypeptide binding]; other site 1401659003720 ADP-ribose binding site [chemical binding]; other site 1401659003721 active site 1401659003722 nudix motif; other site 1401659003723 metal binding site [ion binding]; metal-binding site 1401659003724 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 1401659003725 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 1401659003726 transketolase; Reviewed; Region: PRK12753 1401659003727 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1401659003728 TPP-binding site [chemical binding]; other site 1401659003729 dimer interface [polypeptide binding]; other site 1401659003730 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1401659003731 PYR/PP interface [polypeptide binding]; other site 1401659003732 dimer interface [polypeptide binding]; other site 1401659003733 TPP binding site [chemical binding]; other site 1401659003734 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1401659003735 transaldolase-like protein; Provisional; Region: PTZ00411 1401659003736 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1401659003737 active site 1401659003738 dimer interface [polypeptide binding]; other site 1401659003739 catalytic residue [active] 1401659003740 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 1401659003741 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1401659003742 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1401659003743 putative NAD(P) binding site [chemical binding]; other site 1401659003744 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1401659003745 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 1401659003746 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1401659003747 Walker A/P-loop; other site 1401659003748 ATP binding site [chemical binding]; other site 1401659003749 Q-loop/lid; other site 1401659003750 ABC transporter signature motif; other site 1401659003751 Walker B; other site 1401659003752 D-loop; other site 1401659003753 H-loop/switch region; other site 1401659003754 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1401659003755 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1401659003756 ABC-ATPase subunit interface; other site 1401659003757 dimer interface [polypeptide binding]; other site 1401659003758 putative PBP binding regions; other site 1401659003759 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1401659003760 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1401659003761 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1401659003762 ABC-ATPase subunit interface; other site 1401659003763 dimer interface [polypeptide binding]; other site 1401659003764 putative PBP binding regions; other site 1401659003765 enterobactin exporter EntS; Provisional; Region: PRK10489 1401659003766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659003767 putative substrate translocation pore; other site 1401659003768 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 1401659003769 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1401659003770 intersubunit interface [polypeptide binding]; other site 1401659003771 isochorismate synthase EntC; Provisional; Region: PRK15016 1401659003772 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1401659003773 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 1401659003774 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1401659003775 acyl-activating enzyme (AAE) consensus motif; other site 1401659003776 active site 1401659003777 AMP binding site [chemical binding]; other site 1401659003778 substrate binding site [chemical binding]; other site 1401659003779 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1401659003780 hydrophobic substrate binding pocket; other site 1401659003781 Isochorismatase family; Region: Isochorismatase; pfam00857 1401659003782 active site 1401659003783 conserved cis-peptide bond; other site 1401659003784 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1401659003785 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1401659003786 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1401659003787 NAD(P) binding site [chemical binding]; other site 1401659003788 active site 1401659003789 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1401659003790 CoenzymeA binding site [chemical binding]; other site 1401659003791 subunit interaction site [polypeptide binding]; other site 1401659003792 PHB binding site; other site 1401659003793 carbon starvation protein A; Provisional; Region: PRK15015 1401659003794 Carbon starvation protein CstA; Region: CstA; pfam02554 1401659003795 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1401659003796 Uncharacterized small protein [Function unknown]; Region: COG2879 1401659003797 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1401659003798 salt bridge; other site 1401659003799 non-specific DNA binding site [nucleotide binding]; other site 1401659003800 sequence-specific DNA binding site [nucleotide binding]; other site 1401659003801 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1401659003802 enterobactin exporter EntS; Provisional; Region: PRK10489 1401659003803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1401659003804 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1401659003805 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 1401659003806 putative active site [active] 1401659003807 metal binding site [ion binding]; metal-binding site 1401659003808 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1401659003809 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1401659003810 Walker A/P-loop; other site 1401659003811 ATP binding site [chemical binding]; other site 1401659003812 Q-loop/lid; other site 1401659003813 ABC transporter signature motif; other site 1401659003814 Walker B; other site 1401659003815 D-loop; other site 1401659003816 H-loop/switch region; other site 1401659003817 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1401659003818 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1401659003819 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1401659003820 TM-ABC transporter signature motif; other site 1401659003821 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 1401659003822 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1401659003823 putative ligand binding site [chemical binding]; other site 1401659003824 Uncharacterized conserved protein [Function unknown]; Region: COG5276 1401659003825 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 1401659003826 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1401659003827 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1401659003828 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1401659003829 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1401659003830 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 1401659003831 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1401659003832 active site 1401659003833 metal binding site [ion binding]; metal-binding site 1401659003834 putative acetyltransferase; Provisional; Region: PRK03624 1401659003835 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1401659003836 Coenzyme A binding pocket [chemical binding]; other site 1401659003837 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 1401659003838 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 1401659003839 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 1401659003840 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 1401659003841 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1401659003842 thiosulfate transporter subunit; Provisional; Region: PRK10852 1401659003843 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1401659003844 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1401659003845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659003846 dimer interface [polypeptide binding]; other site 1401659003847 conserved gate region; other site 1401659003848 putative PBP binding loops; other site 1401659003849 ABC-ATPase subunit interface; other site 1401659003850 sulfate transport protein; Provisional; Region: cysT; CHL00187 1401659003851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659003852 dimer interface [polypeptide binding]; other site 1401659003853 conserved gate region; other site 1401659003854 putative PBP binding loops; other site 1401659003855 ABC-ATPase subunit interface; other site 1401659003856 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 1401659003857 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1401659003858 Walker A/P-loop; other site 1401659003859 ATP binding site [chemical binding]; other site 1401659003860 Q-loop/lid; other site 1401659003861 ABC transporter signature motif; other site 1401659003862 Walker B; other site 1401659003863 D-loop; other site 1401659003864 H-loop/switch region; other site 1401659003865 TOBE-like domain; Region: TOBE_3; pfam12857 1401659003866 cysteine synthase B; Region: cysM; TIGR01138 1401659003867 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1401659003868 dimer interface [polypeptide binding]; other site 1401659003869 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659003870 catalytic residue [active] 1401659003871 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1401659003872 HPr interaction site; other site 1401659003873 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1401659003874 active site 1401659003875 phosphorylation site [posttranslational modification] 1401659003876 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 1401659003877 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1401659003878 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1401659003879 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1401659003880 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1401659003881 dimerization domain swap beta strand [polypeptide binding]; other site 1401659003882 regulatory protein interface [polypeptide binding]; other site 1401659003883 active site 1401659003884 regulatory phosphorylation site [posttranslational modification]; other site 1401659003885 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1401659003886 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1401659003887 dimer interface [polypeptide binding]; other site 1401659003888 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659003889 catalytic residue [active] 1401659003890 putative sulfate transport protein CysZ; Validated; Region: PRK04949 1401659003891 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 1401659003892 FtsZ protein binding site [polypeptide binding]; other site 1401659003893 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1401659003894 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1401659003895 nucleotide binding pocket [chemical binding]; other site 1401659003896 K-X-D-G motif; other site 1401659003897 catalytic site [active] 1401659003898 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1401659003899 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1401659003900 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1401659003901 Dimer interface [polypeptide binding]; other site 1401659003902 BRCT sequence motif; other site 1401659003903 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 1401659003904 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1401659003905 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1401659003906 active site 1401659003907 HIGH motif; other site 1401659003908 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1401659003909 active site 1401659003910 KMSKS motif; other site 1401659003911 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 1401659003912 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 1401659003913 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1401659003914 diguanylate cyclase; Region: GGDEF; smart00267 1401659003915 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1401659003916 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1401659003917 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1401659003918 Nucleoside recognition; Region: Gate; pfam07670 1401659003919 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1401659003920 manganese transport protein MntH; Reviewed; Region: PRK00701 1401659003921 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1401659003922 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 1401659003923 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1401659003924 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1401659003925 active site 1401659003926 catalytic tetrad [active] 1401659003927 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 1401659003928 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1401659003929 dimer interface [polypeptide binding]; other site 1401659003930 PYR/PP interface [polypeptide binding]; other site 1401659003931 TPP binding site [chemical binding]; other site 1401659003932 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1401659003933 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1401659003934 TPP-binding site [chemical binding]; other site 1401659003935 dimer interface [polypeptide binding]; other site 1401659003936 glucokinase, proteobacterial type; Region: glk; TIGR00749 1401659003937 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1401659003938 nucleotide binding site [chemical binding]; other site 1401659003939 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1401659003940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1401659003941 active site 1401659003942 phosphorylation site [posttranslational modification] 1401659003943 intermolecular recognition site; other site 1401659003944 dimerization interface [polypeptide binding]; other site 1401659003945 LytTr DNA-binding domain; Region: LytTR; pfam04397 1401659003946 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1401659003947 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1401659003948 GAF domain; Region: GAF_3; pfam13492 1401659003949 Histidine kinase; Region: His_kinase; pfam06580 1401659003950 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1401659003951 ATP binding site [chemical binding]; other site 1401659003952 Mg2+ binding site [ion binding]; other site 1401659003953 G-X-G motif; other site 1401659003954 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 1401659003955 aminotransferase; Validated; Region: PRK08175 1401659003956 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1401659003957 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659003958 homodimer interface [polypeptide binding]; other site 1401659003959 catalytic residue [active] 1401659003960 Cupin domain; Region: Cupin_2; pfam07883 1401659003961 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1401659003962 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1401659003963 oligomer interface [polypeptide binding]; other site 1401659003964 metal binding site [ion binding]; metal-binding site 1401659003965 metal binding site [ion binding]; metal-binding site 1401659003966 putative Cl binding site [ion binding]; other site 1401659003967 basic sphincter; other site 1401659003968 hydrophobic gate; other site 1401659003969 periplasmic entrance; other site 1401659003970 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1401659003971 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659003972 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 1401659003973 putative dimerization interface [polypeptide binding]; other site 1401659003974 putative substrate binding pocket [chemical binding]; other site 1401659003975 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 1401659003976 acetolactate synthase; Reviewed; Region: PRK08617 1401659003977 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1401659003978 PYR/PP interface [polypeptide binding]; other site 1401659003979 dimer interface [polypeptide binding]; other site 1401659003980 TPP binding site [chemical binding]; other site 1401659003981 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1401659003982 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1401659003983 TPP-binding site [chemical binding]; other site 1401659003984 acetoin reductase; Validated; Region: PRK08643 1401659003985 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 1401659003986 NAD binding site [chemical binding]; other site 1401659003987 homotetramer interface [polypeptide binding]; other site 1401659003988 homodimer interface [polypeptide binding]; other site 1401659003989 active site 1401659003990 substrate binding site [chemical binding]; other site 1401659003991 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1401659003992 amphipathic channel; other site 1401659003993 Asn-Pro-Ala signature motifs; other site 1401659003994 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1401659003995 Protein of unknown function (DUF2737); Region: DUF2737; pfam10930 1401659003996 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 1401659003997 RecT family; Region: RecT; pfam03837 1401659003998 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 1401659003999 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1401659004000 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1401659004001 non-specific DNA binding site [nucleotide binding]; other site 1401659004002 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1401659004003 salt bridge; other site 1401659004004 sequence-specific DNA binding site [nucleotide binding]; other site 1401659004005 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1401659004006 Catalytic site [active] 1401659004007 Bacteriophage CII protein; Region: Phage_CII; pfam05269 1401659004008 ParB-like nuclease domain; Region: ParB; smart00470 1401659004009 KorB domain; Region: KorB; pfam08535 1401659004010 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 1401659004011 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1401659004012 replicative DNA helicase; Region: DnaB; TIGR00665 1401659004013 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1401659004014 Walker A motif; other site 1401659004015 ATP binding site [chemical binding]; other site 1401659004016 Walker B motif; other site 1401659004017 DNA binding loops [nucleotide binding] 1401659004018 NinB protein; Region: NinB; pfam05772 1401659004019 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442 1401659004020 Endodeoxyribonuclease RusA; Region: RusA; cl01885 1401659004021 Antitermination protein; Region: Antiterm; pfam03589 1401659004022 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 1401659004023 Antitermination protein; Region: Antiterm; pfam03589 1401659004024 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1401659004025 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 1401659004026 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 1401659004027 Head fiber protein; Region: Phage_head_fibr; pfam11133 1401659004028 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 1401659004029 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 1401659004030 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 1401659004031 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 1401659004032 formyl-CoA transferase; Region: oxalate_frc; TIGR03253 1401659004033 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 1401659004034 virion protein; Provisional; Region: V; PHA02564 1401659004035 valyl-tRNA synthetase; Provisional; Region: valS; PRK14900 1401659004036 Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; cl15410 1401659004037 Baseplate J-like protein; Region: Baseplate_J; cl01294 1401659004038 Phage Tail Collar Domain; Region: Collar; pfam07484 1401659004039 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1401659004040 integrase; Provisional; Region: PRK09692 1401659004041 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1401659004042 active site 1401659004043 Int/Topo IB signature motif; other site 1401659004044 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 1401659004045 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 1401659004046 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 1401659004047 Walker A/P-loop; other site 1401659004048 ATP binding site [chemical binding]; other site 1401659004049 Q-loop/lid; other site 1401659004050 ABC transporter signature motif; other site 1401659004051 Walker B; other site 1401659004052 D-loop; other site 1401659004053 H-loop/switch region; other site 1401659004054 heme exporter protein CcmB; Region: ccmB; TIGR01190 1401659004055 heme exporter protein CcmC; Region: ccmC; TIGR01191 1401659004056 Heme exporter protein D (CcmD); Region: CcmD; cl11475 1401659004057 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150 1401659004058 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 1401659004059 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 1401659004060 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1401659004061 catalytic residues [active] 1401659004062 central insert; other site 1401659004063 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 1401659004064 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 1401659004065 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 1401659004066 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1401659004067 binding surface 1401659004068 TPR motif; other site 1401659004069 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 1401659004070 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 1401659004071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 1401659004072 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 1401659004073 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1401659004074 dimer interface [polypeptide binding]; other site 1401659004075 active site 1401659004076 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1401659004077 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1401659004078 substrate binding site [chemical binding]; other site 1401659004079 oxyanion hole (OAH) forming residues; other site 1401659004080 trimer interface [polypeptide binding]; other site 1401659004081 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1401659004082 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1401659004083 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1401659004084 catalytic core [active] 1401659004085 hypothetical protein; Provisional; Region: PRK04946 1401659004086 Smr domain; Region: Smr; pfam01713 1401659004087 HemK family putative methylases; Region: hemK_fam; TIGR00536 1401659004088 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1401659004089 S-adenosylmethionine binding site [chemical binding]; other site 1401659004090 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1401659004091 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1401659004092 Tetramer interface [polypeptide binding]; other site 1401659004093 active site 1401659004094 FMN-binding site [chemical binding]; other site 1401659004095 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 1401659004096 hypothetical protein; Provisional; Region: PRK10621 1401659004097 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1401659004098 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 1401659004099 YfcL protein; Region: YfcL; pfam08891 1401659004100 Uncharacterized conserved protein [Function unknown]; Region: COG4121 1401659004101 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 1401659004102 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1401659004103 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1401659004104 dimer interface [polypeptide binding]; other site 1401659004105 active site 1401659004106 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 1401659004107 catalytic triad [active] 1401659004108 putative active site [active] 1401659004109 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 1401659004110 Autotransporter beta-domain; Region: Autotransporter; smart00869 1401659004111 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 1401659004112 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 1401659004113 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 1401659004114 ligand binding site [chemical binding]; other site 1401659004115 NAD binding site [chemical binding]; other site 1401659004116 catalytic site [active] 1401659004117 homodimer interface [polypeptide binding]; other site 1401659004118 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 1401659004119 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1401659004120 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1401659004121 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1401659004122 dimerization interface 3.5A [polypeptide binding]; other site 1401659004123 active site 1401659004124 hypothetical protein; Provisional; Region: PRK10847 1401659004125 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1401659004126 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1401659004127 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1401659004128 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 1401659004129 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1401659004130 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1401659004131 cell division protein DedD; Provisional; Region: PRK11633 1401659004132 Sporulation related domain; Region: SPOR; pfam05036 1401659004133 Colicin V production protein; Region: Colicin_V; cl00567 1401659004134 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1401659004135 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1401659004136 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1401659004137 active site 1401659004138 tetramer interface [polypeptide binding]; other site 1401659004139 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1401659004140 active site 1401659004141 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 1401659004142 Flavoprotein; Region: Flavoprotein; pfam02441 1401659004143 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 1401659004144 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1401659004145 substrate binding pocket [chemical binding]; other site 1401659004146 membrane-bound complex binding site; other site 1401659004147 hinge residues; other site 1401659004148 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 1401659004149 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1401659004150 substrate binding pocket [chemical binding]; other site 1401659004151 membrane-bound complex binding site; other site 1401659004152 hinge residues; other site 1401659004153 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1401659004154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659004155 dimer interface [polypeptide binding]; other site 1401659004156 conserved gate region; other site 1401659004157 putative PBP binding loops; other site 1401659004158 ABC-ATPase subunit interface; other site 1401659004159 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1401659004160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659004161 dimer interface [polypeptide binding]; other site 1401659004162 conserved gate region; other site 1401659004163 putative PBP binding loops; other site 1401659004164 ABC-ATPase subunit interface; other site 1401659004165 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 1401659004166 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1401659004167 Walker A/P-loop; other site 1401659004168 ATP binding site [chemical binding]; other site 1401659004169 Q-loop/lid; other site 1401659004170 ABC transporter signature motif; other site 1401659004171 Walker B; other site 1401659004172 D-loop; other site 1401659004173 H-loop/switch region; other site 1401659004174 RES domain; Region: RES; smart00953 1401659004175 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1401659004176 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1401659004177 NAD(P) binding site [chemical binding]; other site 1401659004178 active site 1401659004179 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1401659004180 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1401659004181 C-terminal domain interface [polypeptide binding]; other site 1401659004182 GSH binding site (G-site) [chemical binding]; other site 1401659004183 dimer interface [polypeptide binding]; other site 1401659004184 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1401659004185 N-terminal domain interface [polypeptide binding]; other site 1401659004186 putative dimer interface [polypeptide binding]; other site 1401659004187 active site 1401659004188 glutathione S-transferase; Provisional; Region: PRK15113 1401659004189 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1401659004190 C-terminal domain interface [polypeptide binding]; other site 1401659004191 GSH binding site (G-site) [chemical binding]; other site 1401659004192 dimer interface [polypeptide binding]; other site 1401659004193 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 1401659004194 N-terminal domain interface [polypeptide binding]; other site 1401659004195 putative dimer interface [polypeptide binding]; other site 1401659004196 putative substrate binding pocket (H-site) [chemical binding]; other site 1401659004197 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1401659004198 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1401659004199 active site 1401659004200 metal binding site [ion binding]; metal-binding site 1401659004201 homotetramer interface [polypeptide binding]; other site 1401659004202 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 1401659004203 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1401659004204 nudix motif; other site 1401659004205 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1401659004206 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1401659004207 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1401659004208 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1401659004209 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1401659004210 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 1401659004211 phosphate acetyltransferase; Reviewed; Region: PRK05632 1401659004212 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1401659004213 DRTGG domain; Region: DRTGG; pfam07085 1401659004214 phosphate acetyltransferase; Region: pta; TIGR00651 1401659004215 propionate/acetate kinase; Provisional; Region: PRK12379 1401659004216 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1401659004217 hypothetical protein; Provisional; Region: PRK01816 1401659004218 hypothetical protein; Validated; Region: PRK05445 1401659004219 putative phosphatase; Provisional; Region: PRK11587 1401659004220 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1401659004221 motif II; other site 1401659004222 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1401659004223 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1401659004224 TrkA-C domain; Region: TrkA_C; pfam02080 1401659004225 TrkA-C domain; Region: TrkA_C; pfam02080 1401659004226 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1401659004227 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1401659004228 Zn2+ binding site [ion binding]; other site 1401659004229 Mg2+ binding site [ion binding]; other site 1401659004230 aminotransferase AlaT; Validated; Region: PRK09265 1401659004231 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1401659004232 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659004233 homodimer interface [polypeptide binding]; other site 1401659004234 catalytic residue [active] 1401659004235 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 1401659004236 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659004237 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 1401659004238 putative dimerization interface [polypeptide binding]; other site 1401659004239 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1401659004240 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 1401659004241 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 1401659004242 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1401659004243 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1401659004244 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1401659004245 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1401659004246 putative dimer interface [polypeptide binding]; other site 1401659004247 [2Fe-2S] cluster binding site [ion binding]; other site 1401659004248 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 1401659004249 SLBB domain; Region: SLBB; pfam10531 1401659004250 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1401659004251 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 1401659004252 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1401659004253 catalytic loop [active] 1401659004254 iron binding site [ion binding]; other site 1401659004255 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1401659004256 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1401659004257 [4Fe-4S] binding site [ion binding]; other site 1401659004258 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1401659004259 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1401659004260 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 1401659004261 4Fe-4S binding domain; Region: Fer4; cl02805 1401659004262 4Fe-4S binding domain; Region: Fer4; pfam00037 1401659004263 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1401659004264 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1401659004265 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1401659004266 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1401659004267 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1401659004268 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1401659004269 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1401659004270 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1401659004271 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1401659004272 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1401659004273 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1401659004274 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1401659004275 Coenzyme A binding pocket [chemical binding]; other site 1401659004276 hypothetical protein; Provisional; Region: PRK10404 1401659004277 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 1401659004278 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1401659004279 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1401659004280 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1401659004281 dimer interface [polypeptide binding]; other site 1401659004282 tetramer interface [polypeptide binding]; other site 1401659004283 PYR/PP interface [polypeptide binding]; other site 1401659004284 TPP binding site [chemical binding]; other site 1401659004285 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1401659004286 TPP-binding site; other site 1401659004287 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 1401659004288 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1401659004289 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1401659004290 substrate binding site [chemical binding]; other site 1401659004291 oxyanion hole (OAH) forming residues; other site 1401659004292 trimer interface [polypeptide binding]; other site 1401659004293 O-succinylbenzoate synthase; Provisional; Region: PRK05105 1401659004294 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1401659004295 active site 1401659004296 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 1401659004297 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1401659004298 acyl-activating enzyme (AAE) consensus motif; other site 1401659004299 putative AMP binding site [chemical binding]; other site 1401659004300 putative active site [active] 1401659004301 putative CoA binding site [chemical binding]; other site 1401659004302 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1401659004303 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1401659004304 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1401659004305 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 1401659004306 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1401659004307 active site 1401659004308 phosphorylation site [posttranslational modification] 1401659004309 intermolecular recognition site; other site 1401659004310 dimerization interface [polypeptide binding]; other site 1401659004311 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1401659004312 DNA binding site [nucleotide binding] 1401659004313 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 1401659004314 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1401659004315 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1401659004316 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1401659004317 dimer interface [polypeptide binding]; other site 1401659004318 phosphorylation site [posttranslational modification] 1401659004319 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1401659004320 ATP binding site [chemical binding]; other site 1401659004321 G-X-G motif; other site 1401659004322 YfaZ precursor; Region: YfaZ; pfam07437 1401659004323 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 1401659004324 hypothetical protein; Provisional; Region: PRK03673 1401659004325 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1401659004326 putative MPT binding site; other site 1401659004327 Competence-damaged protein; Region: CinA; cl00666 1401659004328 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1401659004329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659004330 putative substrate translocation pore; other site 1401659004331 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 1401659004332 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 1401659004333 active site 1401659004334 catalytic site [active] 1401659004335 metal binding site [ion binding]; metal-binding site 1401659004336 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1401659004337 catalytic loop [active] 1401659004338 iron binding site [ion binding]; other site 1401659004339 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1401659004340 dimer interface [polypeptide binding]; other site 1401659004341 putative radical transfer pathway; other site 1401659004342 diiron center [ion binding]; other site 1401659004343 tyrosyl radical; other site 1401659004344 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 1401659004345 ATP cone domain; Region: ATP-cone; pfam03477 1401659004346 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1401659004347 active site 1401659004348 dimer interface [polypeptide binding]; other site 1401659004349 catalytic residues [active] 1401659004350 effector binding site; other site 1401659004351 R2 peptide binding site; other site 1401659004352 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1401659004353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1401659004354 S-adenosylmethionine binding site [chemical binding]; other site 1401659004355 DNA gyrase subunit A; Validated; Region: PRK05560 1401659004356 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1401659004357 CAP-like domain; other site 1401659004358 active site 1401659004359 primary dimer interface [polypeptide binding]; other site 1401659004360 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1401659004361 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1401659004362 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1401659004363 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1401659004364 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1401659004365 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1401659004366 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 1401659004367 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1401659004368 dimer interface [polypeptide binding]; other site 1401659004369 phosphorylation site [posttranslational modification] 1401659004370 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1401659004371 ATP binding site [chemical binding]; other site 1401659004372 Mg2+ binding site [ion binding]; other site 1401659004373 G-X-G motif; other site 1401659004374 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 1401659004375 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1401659004376 active site 1401659004377 phosphorylation site [posttranslational modification] 1401659004378 intermolecular recognition site; other site 1401659004379 dimerization interface [polypeptide binding]; other site 1401659004380 transcriptional regulator RcsB; Provisional; Region: PRK10840 1401659004381 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1401659004382 active site 1401659004383 phosphorylation site [posttranslational modification] 1401659004384 intermolecular recognition site; other site 1401659004385 dimerization interface [polypeptide binding]; other site 1401659004386 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1401659004387 DNA binding residues [nucleotide binding] 1401659004388 dimerization interface [polypeptide binding]; other site 1401659004389 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 1401659004390 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1401659004391 ATP binding site [chemical binding]; other site 1401659004392 Mg2+ binding site [ion binding]; other site 1401659004393 G-X-G motif; other site 1401659004394 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1401659004395 putative binding surface; other site 1401659004396 active site 1401659004397 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1401659004398 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1401659004399 trimer interface [polypeptide binding]; other site 1401659004400 eyelet of channel; other site 1401659004401 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 1401659004402 ApbE family; Region: ApbE; pfam02424 1401659004403 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 1401659004404 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1401659004405 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1401659004406 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1401659004407 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1401659004408 DNA binding site [nucleotide binding] 1401659004409 active site 1401659004410 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 1401659004411 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 1401659004412 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1401659004413 Walker A/P-loop; other site 1401659004414 ATP binding site [chemical binding]; other site 1401659004415 Q-loop/lid; other site 1401659004416 ABC transporter signature motif; other site 1401659004417 Walker B; other site 1401659004418 D-loop; other site 1401659004419 H-loop/switch region; other site 1401659004420 high affinity sulphate transporter 1; Region: sulP; TIGR00815 1401659004421 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1401659004422 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1401659004423 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1401659004424 KTSC domain; Region: KTSC; pfam13619 1401659004425 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1401659004426 EamA-like transporter family; Region: EamA; pfam00892 1401659004427 EamA-like transporter family; Region: EamA; pfam00892 1401659004428 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 1401659004429 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 1401659004430 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 1401659004431 Sulfatase; Region: Sulfatase; cl17466 1401659004432 hypothetical protein; Provisional; Region: PRK13689 1401659004433 Nucleoid-associated protein [General function prediction only]; Region: COG3081 1401659004434 nucleoid-associated protein NdpA; Validated; Region: PRK00378 1401659004435 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1401659004436 5S rRNA interface [nucleotide binding]; other site 1401659004437 CTC domain interface [polypeptide binding]; other site 1401659004438 L16 interface [polypeptide binding]; other site 1401659004439 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1401659004440 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1401659004441 ATP binding site [chemical binding]; other site 1401659004442 putative Mg++ binding site [ion binding]; other site 1401659004443 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1401659004444 nucleotide binding region [chemical binding]; other site 1401659004445 ATP-binding site [chemical binding]; other site 1401659004446 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 1401659004447 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 1401659004448 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1401659004449 RNA binding surface [nucleotide binding]; other site 1401659004450 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1401659004451 active site 1401659004452 uracil binding [chemical binding]; other site 1401659004453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659004454 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1401659004455 putative substrate translocation pore; other site 1401659004456 hypothetical protein; Provisional; Region: PRK11835 1401659004457 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 1401659004458 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1401659004459 Walker A/P-loop; other site 1401659004460 ATP binding site [chemical binding]; other site 1401659004461 Q-loop/lid; other site 1401659004462 ABC transporter signature motif; other site 1401659004463 Walker B; other site 1401659004464 D-loop; other site 1401659004465 H-loop/switch region; other site 1401659004466 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1401659004467 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1401659004468 Walker A/P-loop; other site 1401659004469 ATP binding site [chemical binding]; other site 1401659004470 Q-loop/lid; other site 1401659004471 ABC transporter signature motif; other site 1401659004472 Walker B; other site 1401659004473 D-loop; other site 1401659004474 H-loop/switch region; other site 1401659004475 microcin C ABC transporter permease; Provisional; Region: PRK15021 1401659004476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659004477 dimer interface [polypeptide binding]; other site 1401659004478 conserved gate region; other site 1401659004479 ABC-ATPase subunit interface; other site 1401659004480 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1401659004481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659004482 dimer interface [polypeptide binding]; other site 1401659004483 conserved gate region; other site 1401659004484 putative PBP binding loops; other site 1401659004485 ABC-ATPase subunit interface; other site 1401659004486 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1401659004487 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1401659004488 phage resistance protein; Provisional; Region: PRK10551 1401659004489 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1401659004490 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1401659004491 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 1401659004492 NlpC/P60 family; Region: NLPC_P60; pfam00877 1401659004493 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1401659004494 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1401659004495 active site 1401659004496 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1401659004497 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1401659004498 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1401659004499 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1401659004500 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1401659004501 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1401659004502 mannonate dehydratase; Provisional; Region: PRK03906 1401659004503 mannonate dehydratase; Region: uxuA; TIGR00695 1401659004504 elongation factor P; Provisional; Region: PRK04542 1401659004505 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1401659004506 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1401659004507 RNA binding site [nucleotide binding]; other site 1401659004508 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1401659004509 RNA binding site [nucleotide binding]; other site 1401659004510 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1401659004511 Coenzyme A binding pocket [chemical binding]; other site 1401659004512 sugar efflux transporter B; Provisional; Region: PRK15011 1401659004513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659004514 putative substrate translocation pore; other site 1401659004515 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 1401659004516 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1401659004517 active site 1401659004518 phosphorylation site [posttranslational modification] 1401659004519 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1401659004520 dimerization domain swap beta strand [polypeptide binding]; other site 1401659004521 regulatory protein interface [polypeptide binding]; other site 1401659004522 active site 1401659004523 regulatory phosphorylation site [posttranslational modification]; other site 1401659004524 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1401659004525 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1401659004526 putative substrate binding site [chemical binding]; other site 1401659004527 putative ATP binding site [chemical binding]; other site 1401659004528 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 1401659004529 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 1401659004530 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1401659004531 active site 1401659004532 P-loop; other site 1401659004533 phosphorylation site [posttranslational modification] 1401659004534 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 1401659004535 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1401659004536 endonuclease IV; Provisional; Region: PRK01060 1401659004537 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1401659004538 AP (apurinic/apyrimidinic) site pocket; other site 1401659004539 DNA interaction; other site 1401659004540 Metal-binding active site; metal-binding site 1401659004541 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1401659004542 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1401659004543 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659004544 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1401659004545 putative dimerization interface [polypeptide binding]; other site 1401659004546 lysine transporter; Provisional; Region: PRK10836 1401659004547 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1401659004548 S-formylglutathione hydrolase; Region: PLN02442 1401659004549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659004550 putative substrate translocation pore; other site 1401659004551 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1401659004552 GTP cyclohydrolase I; Provisional; Region: PLN03044 1401659004553 active site 1401659004554 Predicted membrane protein [Function unknown]; Region: COG2311 1401659004555 hypothetical protein; Provisional; Region: PRK10835 1401659004556 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 1401659004557 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1401659004558 DNA binding site [nucleotide binding] 1401659004559 domain linker motif; other site 1401659004560 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1401659004561 dimerization interface (closed form) [polypeptide binding]; other site 1401659004562 ligand binding site [chemical binding]; other site 1401659004563 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 1401659004564 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 1401659004565 ligand binding site [chemical binding]; other site 1401659004566 calcium binding site [ion binding]; other site 1401659004567 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1401659004568 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 1401659004569 Walker A/P-loop; other site 1401659004570 ATP binding site [chemical binding]; other site 1401659004571 Q-loop/lid; other site 1401659004572 ABC transporter signature motif; other site 1401659004573 Walker B; other site 1401659004574 D-loop; other site 1401659004575 H-loop/switch region; other site 1401659004576 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1401659004577 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1401659004578 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1401659004579 TM-ABC transporter signature motif; other site 1401659004580 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1401659004581 putative active site [active] 1401659004582 cytidine deaminase; Provisional; Region: PRK09027 1401659004583 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1401659004584 active site 1401659004585 catalytic motif [active] 1401659004586 Zn binding site [ion binding]; other site 1401659004587 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1401659004588 active site 1401659004589 catalytic motif [active] 1401659004590 Zn binding site [ion binding]; other site 1401659004591 hypothetical protein; Provisional; Region: PRK10711 1401659004592 hypothetical protein; Provisional; Region: PRK01821 1401659004593 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 1401659004594 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1401659004595 non-specific DNA binding site [nucleotide binding]; other site 1401659004596 salt bridge; other site 1401659004597 sequence-specific DNA binding site [nucleotide binding]; other site 1401659004598 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 1401659004599 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1401659004600 FMN binding site [chemical binding]; other site 1401659004601 active site 1401659004602 catalytic residues [active] 1401659004603 substrate binding site [chemical binding]; other site 1401659004604 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1401659004605 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659004606 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 1401659004607 putative substrate binding pocket [chemical binding]; other site 1401659004608 putative dimerization interface [polypeptide binding]; other site 1401659004609 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1401659004610 oxidoreductase; Provisional; Region: PRK12743 1401659004611 classical (c) SDRs; Region: SDR_c; cd05233 1401659004612 NAD(P) binding site [chemical binding]; other site 1401659004613 active site 1401659004614 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1401659004615 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1401659004616 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 1401659004617 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1401659004618 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 1401659004619 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1401659004620 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1401659004621 Coenzyme A binding pocket [chemical binding]; other site 1401659004622 D-lactate dehydrogenase; Provisional; Region: PRK11183 1401659004623 FAD binding domain; Region: FAD_binding_4; pfam01565 1401659004624 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 1401659004625 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1401659004626 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1401659004627 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1401659004628 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1401659004629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659004630 dimer interface [polypeptide binding]; other site 1401659004631 conserved gate region; other site 1401659004632 ABC-ATPase subunit interface; other site 1401659004633 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1401659004634 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1401659004635 Walker A/P-loop; other site 1401659004636 ATP binding site [chemical binding]; other site 1401659004637 Q-loop/lid; other site 1401659004638 ABC transporter signature motif; other site 1401659004639 Walker B; other site 1401659004640 D-loop; other site 1401659004641 H-loop/switch region; other site 1401659004642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659004643 putative PBP binding loops; other site 1401659004644 ABC-ATPase subunit interface; other site 1401659004645 transcriptional regulator MirA; Provisional; Region: PRK15043 1401659004646 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 1401659004647 DNA binding residues [nucleotide binding] 1401659004648 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1401659004649 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1401659004650 active site 1401659004651 HIGH motif; other site 1401659004652 KMSKS motif; other site 1401659004653 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1401659004654 tRNA binding surface [nucleotide binding]; other site 1401659004655 anticodon binding site; other site 1401659004656 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1401659004657 dimer interface [polypeptide binding]; other site 1401659004658 putative tRNA-binding site [nucleotide binding]; other site 1401659004659 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1401659004660 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1401659004661 Zn2+ binding site [ion binding]; other site 1401659004662 Mg2+ binding site [ion binding]; other site 1401659004663 Cache domain; Region: Cache_1; pfam02743 1401659004664 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1401659004665 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1401659004666 metal binding site [ion binding]; metal-binding site 1401659004667 active site 1401659004668 I-site; other site 1401659004669 antiporter inner membrane protein; Provisional; Region: PRK11670 1401659004670 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1401659004671 Walker A motif; other site 1401659004672 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1401659004673 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1401659004674 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1401659004675 Coenzyme A binding pocket [chemical binding]; other site 1401659004676 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1401659004677 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1401659004678 GAF domain; Region: GAF_3; pfam13492 1401659004679 Histidine kinase; Region: His_kinase; pfam06580 1401659004680 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1401659004681 ATP binding site [chemical binding]; other site 1401659004682 Mg2+ binding site [ion binding]; other site 1401659004683 G-X-G motif; other site 1401659004684 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 1401659004685 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1401659004686 active site 1401659004687 phosphorylation site [posttranslational modification] 1401659004688 intermolecular recognition site; other site 1401659004689 dimerization interface [polypeptide binding]; other site 1401659004690 LytTr DNA-binding domain; Region: LytTR; pfam04397 1401659004691 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 1401659004692 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1401659004693 dimerization interface [polypeptide binding]; other site 1401659004694 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1401659004695 dimer interface [polypeptide binding]; other site 1401659004696 putative CheW interface [polypeptide binding]; other site 1401659004697 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1401659004698 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1401659004699 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1401659004700 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 1401659004701 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1401659004702 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1401659004703 active site 1401659004704 DNA binding site [nucleotide binding] 1401659004705 Int/Topo IB signature motif; other site 1401659004706 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1401659004707 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1401659004708 active site 1401659004709 catalytic residues [active] 1401659004710 DNA binding site [nucleotide binding] 1401659004711 Int/Topo IB signature motif; other site 1401659004712 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1401659004713 substrate binding site [chemical binding]; other site 1401659004714 multimerization interface [polypeptide binding]; other site 1401659004715 ATP binding site [chemical binding]; other site 1401659004716 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1401659004717 dimer interface [polypeptide binding]; other site 1401659004718 substrate binding site [chemical binding]; other site 1401659004719 ATP binding site [chemical binding]; other site 1401659004720 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 1401659004721 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1401659004722 putative active site; other site 1401659004723 catalytic residue [active] 1401659004724 lipid kinase; Reviewed; Region: PRK13054 1401659004725 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1401659004726 putative protease; Provisional; Region: PRK15452 1401659004727 Peptidase family U32; Region: Peptidase_U32; pfam01136 1401659004728 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 1401659004729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1401659004730 active site 1401659004731 phosphorylation site [posttranslational modification] 1401659004732 intermolecular recognition site; other site 1401659004733 dimerization interface [polypeptide binding]; other site 1401659004734 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1401659004735 DNA binding site [nucleotide binding] 1401659004736 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 1401659004737 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1401659004738 dimerization interface [polypeptide binding]; other site 1401659004739 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1401659004740 dimer interface [polypeptide binding]; other site 1401659004741 phosphorylation site [posttranslational modification] 1401659004742 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1401659004743 ATP binding site [chemical binding]; other site 1401659004744 Mg2+ binding site [ion binding]; other site 1401659004745 G-X-G motif; other site 1401659004746 putative transporter; Provisional; Region: PRK10504 1401659004747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659004748 putative substrate translocation pore; other site 1401659004749 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1401659004750 Protein export membrane protein; Region: SecD_SecF; cl14618 1401659004751 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 1401659004752 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1401659004753 HlyD family secretion protein; Region: HlyD_3; pfam13437 1401659004754 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 1401659004755 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1401659004756 salt bridge; other site 1401659004757 non-specific DNA binding site [nucleotide binding]; other site 1401659004758 sequence-specific DNA binding site [nucleotide binding]; other site 1401659004759 putative chaperone; Provisional; Region: PRK11678 1401659004760 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 1401659004761 nucleotide binding site [chemical binding]; other site 1401659004762 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1401659004763 SBD interface [polypeptide binding]; other site 1401659004764 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 1401659004765 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1401659004766 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1401659004767 minor groove reading motif; other site 1401659004768 helix-hairpin-helix signature motif; other site 1401659004769 substrate binding pocket [chemical binding]; other site 1401659004770 active site 1401659004771 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 1401659004772 putative diguanylate cyclase; Provisional; Region: PRK09776 1401659004773 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1401659004774 putative active site [active] 1401659004775 heme pocket [chemical binding]; other site 1401659004776 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1401659004777 putative active site [active] 1401659004778 heme pocket [chemical binding]; other site 1401659004779 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1401659004780 putative active site [active] 1401659004781 heme pocket [chemical binding]; other site 1401659004782 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1401659004783 metal binding site [ion binding]; metal-binding site 1401659004784 active site 1401659004785 I-site; other site 1401659004786 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 1401659004787 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1401659004788 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1401659004789 ATP-binding site [chemical binding]; other site 1401659004790 Sugar specificity; other site 1401659004791 Pyrimidine base specificity; other site 1401659004792 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1401659004793 trimer interface [polypeptide binding]; other site 1401659004794 active site 1401659004795 putative assembly protein; Provisional; Region: PRK10833 1401659004796 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1401659004797 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1401659004798 FOG: CBS domain [General function prediction only]; Region: COG0517 1401659004799 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1401659004800 Transporter associated domain; Region: CorC_HlyC; smart01091 1401659004801 polysaccharide export protein Wza; Provisional; Region: PRK15078 1401659004802 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1401659004803 SLBB domain; Region: SLBB; pfam10531 1401659004804 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1401659004805 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1401659004806 active site 1401659004807 tyrosine kinase; Provisional; Region: PRK11519 1401659004808 Chain length determinant protein; Region: Wzz; pfam02706 1401659004809 Chain length determinant protein; Region: Wzz; cl15801 1401659004810 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1401659004811 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1401659004812 putative glycosyl transferase; Provisional; Region: PRK10018 1401659004813 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1401659004814 active site 1401659004815 putative acyl transferase; Provisional; Region: PRK10191 1401659004816 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1401659004817 trimer interface [polypeptide binding]; other site 1401659004818 active site 1401659004819 substrate binding site [chemical binding]; other site 1401659004820 CoA binding site [chemical binding]; other site 1401659004821 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1401659004822 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 1401659004823 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 1401659004824 putative glycosyl transferase; Provisional; Region: PRK10063 1401659004825 colanic acid biosynthesis glycosyl transferase WcaE; Region: wcaE; TIGR04009 1401659004826 active site 1401659004827 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 1401659004828 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 1401659004829 putative trimer interface [polypeptide binding]; other site 1401659004830 putative active site [active] 1401659004831 putative substrate binding site [chemical binding]; other site 1401659004832 putative CoA binding site [chemical binding]; other site 1401659004833 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1401659004834 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1401659004835 NADP-binding site; other site 1401659004836 homotetramer interface [polypeptide binding]; other site 1401659004837 substrate binding site [chemical binding]; other site 1401659004838 homodimer interface [polypeptide binding]; other site 1401659004839 active site 1401659004840 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1401659004841 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1401659004842 NADP binding site [chemical binding]; other site 1401659004843 active site 1401659004844 putative substrate binding site [chemical binding]; other site 1401659004845 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 1401659004846 active site 1401659004847 GDP-Mannose binding site [chemical binding]; other site 1401659004848 dimer interface [polypeptide binding]; other site 1401659004849 modified nudix motif 1401659004850 metal binding site [ion binding]; metal-binding site 1401659004851 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 1401659004852 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1401659004853 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 1401659004854 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1401659004855 Substrate binding site; other site 1401659004856 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1401659004857 phosphomannomutase CpsG; Provisional; Region: PRK15414 1401659004858 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1401659004859 active site 1401659004860 substrate binding site [chemical binding]; other site 1401659004861 metal binding site [ion binding]; metal-binding site 1401659004862 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 1401659004863 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1401659004864 colanic acid exporter; Provisional; Region: PRK10459 1401659004865 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1401659004866 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 1401659004867 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 1401659004868 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 1401659004869 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 1401659004870 putative ADP-binding pocket [chemical binding]; other site 1401659004871 colanic acid biosynthesis protein WcaM; Region: WcaM; TIGR04004 1401659004872 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 1401659004873 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1401659004874 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 1401659004875 putative NAD(P) binding site [chemical binding]; other site 1401659004876 active site 1401659004877 putative substrate binding site [chemical binding]; other site 1401659004878 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1401659004879 active site 1401659004880 tetramer interface; other site 1401659004881 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1401659004882 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1401659004883 active site 1401659004884 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 1401659004885 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1401659004886 Core-2/I-Branching enzyme; Region: Branch; pfam02485 1401659004887 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1401659004888 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1401659004889 active site 1401659004890 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1401659004891 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1401659004892 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1401659004893 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1401659004894 chain length determinant protein WzzB; Provisional; Region: PRK15471 1401659004895 Chain length determinant protein; Region: Wzz; pfam02706 1401659004896 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1401659004897 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1401659004898 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1401659004899 metal binding site [ion binding]; metal-binding site 1401659004900 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1401659004901 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1401659004902 substrate binding site [chemical binding]; other site 1401659004903 glutamase interaction surface [polypeptide binding]; other site 1401659004904 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1401659004905 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1401659004906 catalytic residues [active] 1401659004907 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 1401659004908 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1401659004909 putative active site [active] 1401659004910 oxyanion strand; other site 1401659004911 catalytic triad [active] 1401659004912 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 1401659004913 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1401659004914 active site 1401659004915 motif I; other site 1401659004916 motif II; other site 1401659004917 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1401659004918 putative active site pocket [active] 1401659004919 4-fold oligomerization interface [polypeptide binding]; other site 1401659004920 metal binding residues [ion binding]; metal-binding site 1401659004921 3-fold/trimer interface [polypeptide binding]; other site 1401659004922 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 1401659004923 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1401659004924 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659004925 homodimer interface [polypeptide binding]; other site 1401659004926 catalytic residue [active] 1401659004927 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1401659004928 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1401659004929 NAD binding site [chemical binding]; other site 1401659004930 dimerization interface [polypeptide binding]; other site 1401659004931 product binding site; other site 1401659004932 substrate binding site [chemical binding]; other site 1401659004933 zinc binding site [ion binding]; other site 1401659004934 catalytic residues [active] 1401659004935 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1401659004936 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1401659004937 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1401659004938 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1401659004939 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1401659004940 putative NAD(P) binding site [chemical binding]; other site 1401659004941 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 1401659004942 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1401659004943 catalytic triad [active] 1401659004944 4-aminobutyrate aminotransferase; Provisional; Region: PRK07495 1401659004945 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1401659004946 inhibitor-cofactor binding pocket; inhibition site 1401659004947 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659004948 catalytic residue [active] 1401659004949 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1401659004950 exonuclease I; Provisional; Region: sbcB; PRK11779 1401659004951 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1401659004952 active site 1401659004953 catalytic site [active] 1401659004954 substrate binding site [chemical binding]; other site 1401659004955 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1401659004956 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1401659004957 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 1401659004958 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1401659004959 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1401659004960 DNA gyrase inhibitor; Provisional; Region: PRK10016 1401659004961 Predicted membrane protein [Function unknown]; Region: COG1289 1401659004962 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1401659004963 hypothetical protein; Provisional; Region: PRK05423 1401659004964 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 1401659004965 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 1401659004966 MATE family multidrug exporter; Provisional; Region: PRK10189 1401659004967 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 1401659004968 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 1401659004969 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 1401659004970 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 1401659004971 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 1401659004972 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 1401659004973 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 1401659004974 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 1401659004975 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 1401659004976 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 1401659004977 AMP nucleosidase; Provisional; Region: PRK08292 1401659004978 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1401659004979 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1401659004980 Sensors of blue-light using FAD; Region: BLUF; smart01034 1401659004981 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1401659004982 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1401659004983 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1401659004984 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 1401659004985 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659004986 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1401659004987 putative dimerization interface [polypeptide binding]; other site 1401659004988 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 1401659004989 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1401659004990 dimerization interface [polypeptide binding]; other site 1401659004991 shikimate transporter; Provisional; Region: PRK09952 1401659004992 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659004993 putative substrate translocation pore; other site 1401659004994 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 1401659004995 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1401659004996 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1401659004997 metal binding site [ion binding]; metal-binding site 1401659004998 active site 1401659004999 I-site; other site 1401659005000 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1401659005001 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659005002 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1401659005003 putative effector binding pocket; other site 1401659005004 dimerization interface [polypeptide binding]; other site 1401659005005 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1401659005006 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1401659005007 potential catalytic triad [active] 1401659005008 conserved cys residue [active] 1401659005009 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1401659005010 classical (c) SDRs; Region: SDR_c; cd05233 1401659005011 NAD(P) binding site [chemical binding]; other site 1401659005012 active site 1401659005013 DinI-like family; Region: DinI; pfam06183 1401659005014 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1401659005015 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1401659005016 trimer interface [polypeptide binding]; other site 1401659005017 eyelet of channel; other site 1401659005018 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1401659005019 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1401659005020 Zn2+ binding site [ion binding]; other site 1401659005021 Mg2+ binding site [ion binding]; other site 1401659005022 DNA cytosine methylase; Provisional; Region: PRK10458 1401659005023 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1401659005024 cofactor binding site; other site 1401659005025 DNA binding site [nucleotide binding] 1401659005026 substrate interaction site [chemical binding]; other site 1401659005027 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1401659005028 mismatch recognition site; other site 1401659005029 additional DNA contacts [nucleotide binding]; other site 1401659005030 active site 1401659005031 zinc binding site [ion binding]; other site 1401659005032 DNA intercalation site [nucleotide binding]; other site 1401659005033 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1401659005034 EamA-like transporter family; Region: EamA; pfam00892 1401659005035 EamA-like transporter family; Region: EamA; pfam00892 1401659005036 hypothetical protein; Provisional; Region: PRK10062 1401659005037 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 1401659005038 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 1401659005039 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1401659005040 metal binding site [ion binding]; metal-binding site 1401659005041 active site 1401659005042 I-site; other site 1401659005043 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 1401659005044 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1401659005045 active site 1401659005046 motif I; other site 1401659005047 motif II; other site 1401659005048 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 1401659005049 hypothetical protein; Provisional; Region: PRK10708 1401659005050 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 1401659005051 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1401659005052 DNA binding residues [nucleotide binding] 1401659005053 dimerization interface [polypeptide binding]; other site 1401659005054 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1401659005055 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1401659005056 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1401659005057 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 1401659005058 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 1401659005059 flagellar motor switch protein; Validated; Region: fliN; PRK05698 1401659005060 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1401659005061 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1401659005062 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 1401659005063 flagellar hook-length control protein; Provisional; Region: PRK10118 1401659005064 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 1401659005065 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1401659005066 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 1401659005067 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 1401659005068 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1401659005069 Walker A motif/ATP binding site; other site 1401659005070 Walker B motif; other site 1401659005071 flagellar assembly protein H; Validated; Region: fliH; PRK05687 1401659005072 Flagellar assembly protein FliH; Region: FliH; pfam02108 1401659005073 flagellar motor switch protein FliG; Region: fliG; TIGR00207 1401659005074 FliG C-terminal domain; Region: FliG_C; pfam01706 1401659005075 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1401659005076 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1401659005077 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1401659005078 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 1401659005079 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1401659005080 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1401659005081 S-adenosylmethionine binding site [chemical binding]; other site 1401659005082 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 1401659005083 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 1401659005084 CPxP motif; other site 1401659005085 putative inner membrane protein; Provisional; Region: PRK11099 1401659005086 lipoprotein; Provisional; Region: PRK10397 1401659005087 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 1401659005088 flagellar protein FliS; Validated; Region: fliS; PRK05685 1401659005089 flagellar capping protein; Reviewed; Region: fliD; PRK08032 1401659005090 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1401659005091 flagellin; Provisional; Region: PRK12802 1401659005092 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1401659005093 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1401659005094 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1401659005095 S-adenosylmethionine binding site [chemical binding]; other site 1401659005096 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 1401659005097 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1401659005098 binding surface 1401659005099 TPR motif; other site 1401659005100 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1401659005101 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1401659005102 binding surface 1401659005103 TPR motif; other site 1401659005104 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1401659005105 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1401659005106 inhibitor-cofactor binding pocket; inhibition site 1401659005107 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659005108 catalytic residue [active] 1401659005109 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1401659005110 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1401659005111 putative trimer interface [polypeptide binding]; other site 1401659005112 putative CoA binding site [chemical binding]; other site 1401659005113 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1401659005114 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1401659005115 NAD(P) binding site [chemical binding]; other site 1401659005116 active site 1401659005117 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1401659005118 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1401659005119 NAD(P) binding site [chemical binding]; other site 1401659005120 active site 1401659005121 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1401659005122 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1401659005123 AMP binding site [chemical binding]; other site 1401659005124 active site 1401659005125 acyl-activating enzyme (AAE) consensus motif; other site 1401659005126 CoA binding site [chemical binding]; other site 1401659005127 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 1401659005128 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1401659005129 NAD(P) binding site [chemical binding]; other site 1401659005130 catalytic residues [active] 1401659005131 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 1401659005132 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1401659005133 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1401659005134 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1401659005135 DNA binding residues [nucleotide binding] 1401659005136 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 1401659005137 cystine transporter subunit; Provisional; Region: PRK11260 1401659005138 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1401659005139 substrate binding pocket [chemical binding]; other site 1401659005140 membrane-bound complex binding site; other site 1401659005141 hinge residues; other site 1401659005142 D-cysteine desulfhydrase; Validated; Region: PRK03910 1401659005143 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 1401659005144 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659005145 catalytic residue [active] 1401659005146 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1401659005147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659005148 dimer interface [polypeptide binding]; other site 1401659005149 conserved gate region; other site 1401659005150 putative PBP binding loops; other site 1401659005151 ABC-ATPase subunit interface; other site 1401659005152 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 1401659005153 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1401659005154 Walker A/P-loop; other site 1401659005155 ATP binding site [chemical binding]; other site 1401659005156 Q-loop/lid; other site 1401659005157 ABC transporter signature motif; other site 1401659005158 Walker B; other site 1401659005159 D-loop; other site 1401659005160 H-loop/switch region; other site 1401659005161 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 1401659005162 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1401659005163 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1401659005164 DNA binding residues [nucleotide binding] 1401659005165 dimerization interface [polypeptide binding]; other site 1401659005166 hypothetical protein; Provisional; Region: PRK10613 1401659005167 response regulator; Provisional; Region: PRK09483 1401659005168 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1401659005169 active site 1401659005170 phosphorylation site [posttranslational modification] 1401659005171 intermolecular recognition site; other site 1401659005172 dimerization interface [polypeptide binding]; other site 1401659005173 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1401659005174 DNA binding residues [nucleotide binding] 1401659005175 dimerization interface [polypeptide binding]; other site 1401659005176 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1401659005177 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1401659005178 GIY-YIG motif/motif A; other site 1401659005179 active site 1401659005180 catalytic site [active] 1401659005181 putative DNA binding site [nucleotide binding]; other site 1401659005182 metal binding site [ion binding]; metal-binding site 1401659005183 UvrB/uvrC motif; Region: UVR; pfam02151 1401659005184 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1401659005185 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 1401659005186 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1401659005187 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1401659005188 Coenzyme A binding pocket [chemical binding]; other site 1401659005189 tyrosine transporter TyrP; Provisional; Region: PRK15132 1401659005190 aromatic amino acid transport protein; Region: araaP; TIGR00837 1401659005191 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1401659005192 Ferritin-like domain; Region: Ferritin; pfam00210 1401659005193 ferroxidase diiron center [ion binding]; other site 1401659005194 YecR-like lipoprotein; Region: YecR; pfam13992 1401659005195 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1401659005196 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1401659005197 dimer interface [polypeptide binding]; other site 1401659005198 putative CheW interface [polypeptide binding]; other site 1401659005199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659005200 putative transporter; Provisional; Region: PRK10504 1401659005201 putative substrate translocation pore; other site 1401659005202 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 1401659005203 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1401659005204 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1401659005205 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1401659005206 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1401659005207 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1401659005208 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 1401659005209 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1401659005210 Ferritin-like domain; Region: Ferritin; pfam00210 1401659005211 ferroxidase diiron center [ion binding]; other site 1401659005212 DJ-1 family protein; Region: not_thiJ; TIGR01383 1401659005213 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1401659005214 conserved cys residue [active] 1401659005215 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 1401659005216 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1401659005217 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 1401659005218 ligand binding site [chemical binding]; other site 1401659005219 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 1401659005220 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1401659005221 Walker A/P-loop; other site 1401659005222 ATP binding site [chemical binding]; other site 1401659005223 Q-loop/lid; other site 1401659005224 ABC transporter signature motif; other site 1401659005225 Walker B; other site 1401659005226 D-loop; other site 1401659005227 H-loop/switch region; other site 1401659005228 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1401659005229 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1401659005230 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1401659005231 TM-ABC transporter signature motif; other site 1401659005232 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1401659005233 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1401659005234 active site 1401659005235 motif I; other site 1401659005236 motif II; other site 1401659005237 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1401659005238 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1401659005239 active site 1401659005240 homotetramer interface [polypeptide binding]; other site 1401659005241 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1401659005242 Ligand Binding Site [chemical binding]; other site 1401659005243 transcriptional activator FlhD; Provisional; Region: PRK02909 1401659005244 transcriptional activator FlhC; Provisional; Region: PRK12722 1401659005245 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1401659005246 flagellar motor protein MotA; Validated; Region: PRK09110 1401659005247 flagellar motor protein MotB; Validated; Region: motB; PRK09041 1401659005248 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1401659005249 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1401659005250 ligand binding site [chemical binding]; other site 1401659005251 chemotaxis protein CheA; Provisional; Region: PRK10547 1401659005252 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1401659005253 putative binding surface; other site 1401659005254 active site 1401659005255 CheY binding; Region: CheY-binding; pfam09078 1401659005256 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1401659005257 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1401659005258 ATP binding site [chemical binding]; other site 1401659005259 Mg2+ binding site [ion binding]; other site 1401659005260 G-X-G motif; other site 1401659005261 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1401659005262 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1401659005263 putative CheA interaction surface; other site 1401659005264 Spore Coat Protein U domain; Region: SCPU; pfam05229 1401659005265 Spore Coat Protein U domain; Region: SCPU; pfam05229 1401659005266 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1401659005267 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1401659005268 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1401659005269 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1401659005270 PapC C-terminal domain; Region: PapC_C; pfam13953 1401659005271 Spore Coat Protein U domain; Region: SCPU; pfam05229 1401659005272 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1401659005273 dimer interface [polypeptide binding]; other site 1401659005274 ligand binding site [chemical binding]; other site 1401659005275 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1401659005276 dimerization interface [polypeptide binding]; other site 1401659005277 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1401659005278 dimer interface [polypeptide binding]; other site 1401659005279 putative CheW interface [polypeptide binding]; other site 1401659005280 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1401659005281 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1401659005282 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1401659005283 S-adenosylmethionine binding site [chemical binding]; other site 1401659005284 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1401659005285 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1401659005286 active site 1401659005287 phosphorylation site [posttranslational modification] 1401659005288 intermolecular recognition site; other site 1401659005289 dimerization interface [polypeptide binding]; other site 1401659005290 CheB methylesterase; Region: CheB_methylest; pfam01339 1401659005291 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1401659005292 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1401659005293 active site 1401659005294 phosphorylation site [posttranslational modification] 1401659005295 intermolecular recognition site; other site 1401659005296 dimerization interface [polypeptide binding]; other site 1401659005297 chemotaxis regulator CheZ; Provisional; Region: PRK11166 1401659005298 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 1401659005299 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1401659005300 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1401659005301 FHIPEP family; Region: FHIPEP; pfam00771 1401659005302 Flagellar protein FlhE; Region: FlhE; pfam06366 1401659005303 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1401659005304 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659005305 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1401659005306 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 1401659005307 Transcriptional regulator; Region: Rrf2; cl17282 1401659005308 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1401659005309 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1401659005310 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1401659005311 active site 1401659005312 HIGH motif; other site 1401659005313 KMSK motif region; other site 1401659005314 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1401659005315 tRNA binding surface [nucleotide binding]; other site 1401659005316 anticodon binding site; other site 1401659005317 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 1401659005318 putative metal binding site [ion binding]; other site 1401659005319 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 1401659005320 putative hydrophobic ligand binding site [chemical binding]; other site 1401659005321 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1401659005322 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1401659005323 NAD binding site [chemical binding]; other site 1401659005324 catalytic Zn binding site [ion binding]; other site 1401659005325 structural Zn binding site [ion binding]; other site 1401659005326 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 1401659005327 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1401659005328 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659005329 homodimer interface [polypeptide binding]; other site 1401659005330 catalytic residue [active] 1401659005331 copper homeostasis protein CutC; Provisional; Region: PRK11572 1401659005332 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1401659005333 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 1401659005334 nucleotide binding site [chemical binding]; other site 1401659005335 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1401659005336 SBD interface [polypeptide binding]; other site 1401659005337 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1401659005338 HSP70 interaction site [polypeptide binding]; other site 1401659005339 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1401659005340 BON domain; Region: BON; pfam04972 1401659005341 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1401659005342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1401659005343 S-adenosylmethionine binding site [chemical binding]; other site 1401659005344 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1401659005345 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1401659005346 S-adenosylmethionine binding site [chemical binding]; other site 1401659005347 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 1401659005348 hypothetical protein; Provisional; Region: PRK10302 1401659005349 Isochorismatase family; Region: Isochorismatase; pfam00857 1401659005350 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1401659005351 catalytic triad [active] 1401659005352 conserved cis-peptide bond; other site 1401659005353 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1401659005354 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1401659005355 dimer interface [polypeptide binding]; other site 1401659005356 anticodon binding site; other site 1401659005357 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1401659005358 homodimer interface [polypeptide binding]; other site 1401659005359 motif 1; other site 1401659005360 active site 1401659005361 motif 2; other site 1401659005362 GAD domain; Region: GAD; pfam02938 1401659005363 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1401659005364 active site 1401659005365 motif 3; other site 1401659005366 dihydroneopterin triphosphate pyrophosphatase; Provisional; Region: nudB; PRK09438 1401659005367 hypothetical protein; Validated; Region: PRK00110 1401659005368 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1401659005369 active site 1401659005370 putative DNA-binding cleft [nucleotide binding]; other site 1401659005371 dimer interface [polypeptide binding]; other site 1401659005372 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1401659005373 RuvA N terminal domain; Region: RuvA_N; pfam01330 1401659005374 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1401659005375 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1401659005376 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1401659005377 Walker A motif; other site 1401659005378 ATP binding site [chemical binding]; other site 1401659005379 Walker B motif; other site 1401659005380 arginine finger; other site 1401659005381 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1401659005382 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1401659005383 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1401659005384 ABC-ATPase subunit interface; other site 1401659005385 dimer interface [polypeptide binding]; other site 1401659005386 putative PBP binding regions; other site 1401659005387 ABC transporter; Region: ABC_tran; pfam00005 1401659005388 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1401659005389 Q-loop/lid; other site 1401659005390 ABC transporter signature motif; other site 1401659005391 Walker B; other site 1401659005392 D-loop; other site 1401659005393 H-loop/switch region; other site 1401659005394 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1401659005395 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1401659005396 metal binding site [ion binding]; metal-binding site 1401659005397 putative peptidase; Provisional; Region: PRK11649 1401659005398 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1401659005399 Peptidase family M23; Region: Peptidase_M23; pfam01551 1401659005400 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1401659005401 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1401659005402 putative acyl-acceptor binding pocket; other site 1401659005403 pyruvate kinase; Provisional; Region: PRK05826 1401659005404 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1401659005405 domain interfaces; other site 1401659005406 active site 1401659005407 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1401659005408 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1401659005409 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1401659005410 putative active site [active] 1401659005411 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1401659005412 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1401659005413 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1401659005414 phosphogluconate dehydratase; Validated; Region: PRK09054 1401659005415 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1401659005416 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1401659005417 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1401659005418 active site 1401659005419 intersubunit interface [polypeptide binding]; other site 1401659005420 catalytic residue [active] 1401659005421 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1401659005422 ATP-grasp domain; Region: ATP-grasp; pfam02222 1401659005423 YebG protein; Region: YebG; pfam07130 1401659005424 hypothetical protein; Provisional; Region: PRK13680 1401659005425 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 1401659005426 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1401659005427 putative metal binding site [ion binding]; other site 1401659005428 protease 2; Provisional; Region: PRK10115 1401659005429 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1401659005430 exodeoxyribonuclease X; Provisional; Region: PRK07983 1401659005431 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1401659005432 active site 1401659005433 catalytic site [active] 1401659005434 substrate binding site [chemical binding]; other site 1401659005435 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 1401659005436 CopC domain; Region: CopC; cl01012 1401659005437 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1401659005438 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 1401659005439 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 1401659005440 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1401659005441 active site 1401659005442 metal binding site [ion binding]; metal-binding site 1401659005443 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 1401659005444 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 1401659005445 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 1401659005446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1401659005447 S-adenosylmethionine binding site [chemical binding]; other site 1401659005448 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1401659005449 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1401659005450 mce related protein; Region: MCE; pfam02470 1401659005451 mce related protein; Region: MCE; pfam02470 1401659005452 mce related protein; Region: MCE; pfam02470 1401659005453 mce related protein; Region: MCE; pfam02470 1401659005454 mce related protein; Region: MCE; pfam02470 1401659005455 mce related protein; Region: MCE; pfam02470 1401659005456 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 1401659005457 Paraquat-inducible protein A; Region: PqiA; pfam04403 1401659005458 Paraquat-inducible protein A; Region: PqiA; pfam04403 1401659005459 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1401659005460 GAF domain; Region: GAF_2; pfam13185 1401659005461 ProP expression regulator; Provisional; Region: PRK04950 1401659005462 ProQ/FINO family; Region: ProQ; pfam04352 1401659005463 carboxy-terminal protease; Provisional; Region: PRK11186 1401659005464 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1401659005465 protein binding site [polypeptide binding]; other site 1401659005466 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1401659005467 Catalytic dyad [active] 1401659005468 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 1401659005469 heat shock protein HtpX; Provisional; Region: PRK05457 1401659005470 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 1401659005471 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1401659005472 Bacterial transcriptional regulator; Region: IclR; pfam01614 1401659005473 YobH-like protein; Region: YobH; pfam13996 1401659005474 PhoPQ regulatory protein; Provisional; Region: PRK10299 1401659005475 YebO-like protein; Region: YebO; pfam13974 1401659005476 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1401659005477 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1401659005478 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1401659005479 DNA-binding site [nucleotide binding]; DNA binding site 1401659005480 RNA-binding motif; other site 1401659005481 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1401659005482 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1401659005483 S-adenosylmethionine binding site [chemical binding]; other site 1401659005484 hypothetical protein; Provisional; Region: PRK11469 1401659005485 Domain of unknown function DUF; Region: DUF204; pfam02659 1401659005486 Domain of unknown function DUF; Region: DUF204; pfam02659 1401659005487 hypothetical protein; Provisional; Region: PRK02913 1401659005488 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 1401659005489 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1401659005490 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1401659005491 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1401659005492 active pocket/dimerization site; other site 1401659005493 active site 1401659005494 phosphorylation site [posttranslational modification] 1401659005495 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1401659005496 active site 1401659005497 phosphorylation site [posttranslational modification] 1401659005498 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1401659005499 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1401659005500 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1401659005501 Transporter associated domain; Region: CorC_HlyC; smart01091 1401659005502 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1401659005503 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1401659005504 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1401659005505 L-serine deaminase; Provisional; Region: PRK15023 1401659005506 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1401659005507 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1401659005508 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1401659005509 putative active site [active] 1401659005510 putative CoA binding site [chemical binding]; other site 1401659005511 nudix motif; other site 1401659005512 metal binding site [ion binding]; metal-binding site 1401659005513 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 1401659005514 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1401659005515 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 1401659005516 hypothetical protein; Provisional; Region: PRK05114 1401659005517 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 1401659005518 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1401659005519 dimer interface [polypeptide binding]; other site 1401659005520 active site 1401659005521 CoA binding pocket [chemical binding]; other site 1401659005522 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1401659005523 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1401659005524 NAD(P) binding site [chemical binding]; other site 1401659005525 active site 1401659005526 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1401659005527 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1401659005528 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 1401659005529 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 1401659005530 active site 1401659005531 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1401659005532 homotrimer interaction site [polypeptide binding]; other site 1401659005533 putative active site [active] 1401659005534 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1401659005535 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1401659005536 ATP binding site [chemical binding]; other site 1401659005537 DEAD_2; Region: DEAD_2; pfam06733 1401659005538 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1401659005539 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1401659005540 Glycoprotease family; Region: Peptidase_M22; pfam00814 1401659005541 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 1401659005542 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 1401659005543 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1401659005544 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1401659005545 acyl-activating enzyme (AAE) consensus motif; other site 1401659005546 putative AMP binding site [chemical binding]; other site 1401659005547 putative active site [active] 1401659005548 putative CoA binding site [chemical binding]; other site 1401659005549 ribonuclease D; Provisional; Region: PRK10829 1401659005550 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1401659005551 catalytic site [active] 1401659005552 putative active site [active] 1401659005553 putative substrate binding site [chemical binding]; other site 1401659005554 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1401659005555 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1401659005556 cell division inhibitor MinD; Provisional; Region: PRK10818 1401659005557 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1401659005558 Switch I; other site 1401659005559 Switch II; other site 1401659005560 septum formation inhibitor; Reviewed; Region: minC; PRK03511 1401659005561 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1401659005562 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1401659005563 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 1401659005564 hypothetical protein; Provisional; Region: PRK10691 1401659005565 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1401659005566 hypothetical protein; Provisional; Region: PRK05170 1401659005567 disulfide bond formation protein B; Provisional; Region: PRK01749 1401659005568 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1401659005569 transmembrane helices; other site 1401659005570 fatty acid metabolism regulator; Provisional; Region: PRK04984 1401659005571 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1401659005572 DNA-binding site [nucleotide binding]; DNA binding site 1401659005573 FadR C-terminal domain; Region: FadR_C; pfam07840 1401659005574 SpoVR family protein; Provisional; Region: PRK11767 1401659005575 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1401659005576 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1401659005577 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1401659005578 alanine racemase; Reviewed; Region: dadX; PRK03646 1401659005579 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1401659005580 active site 1401659005581 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1401659005582 substrate binding site [chemical binding]; other site 1401659005583 catalytic residues [active] 1401659005584 dimer interface [polypeptide binding]; other site 1401659005585 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 1401659005586 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1401659005587 TrkA-C domain; Region: TrkA_C; pfam02080 1401659005588 Transporter associated domain; Region: CorC_HlyC; smart01091 1401659005589 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 1401659005590 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1401659005591 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1401659005592 dimer interface [polypeptide binding]; other site 1401659005593 catalytic triad [active] 1401659005594 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 1401659005595 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1401659005596 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1401659005597 catalytic residue [active] 1401659005598 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1401659005599 Flagellar regulator YcgR; Region: YcgR; pfam07317 1401659005600 PilZ domain; Region: PilZ; cl01260 1401659005601 hypothetical protein; Provisional; Region: PRK10457 1401659005602 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1401659005603 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1401659005604 N-terminal plug; other site 1401659005605 ligand-binding site [chemical binding]; other site 1401659005606 trehalase; Provisional; Region: treA; PRK13271 1401659005607 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 1401659005608 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1401659005609 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1401659005610 DNA-binding site [nucleotide binding]; DNA binding site 1401659005611 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1401659005612 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659005613 homodimer interface [polypeptide binding]; other site 1401659005614 catalytic residue [active] 1401659005615 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1401659005616 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1401659005617 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1401659005618 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1401659005619 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1401659005620 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1401659005621 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1401659005622 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1401659005623 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1401659005624 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1401659005625 putative C-terminal domain interface [polypeptide binding]; other site 1401659005626 putative GSH binding site (G-site) [chemical binding]; other site 1401659005627 putative dimer interface [polypeptide binding]; other site 1401659005628 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1401659005629 putative N-terminal domain interface [polypeptide binding]; other site 1401659005630 putative dimer interface [polypeptide binding]; other site 1401659005631 putative substrate binding pocket (H-site) [chemical binding]; other site 1401659005632 Polyomavirus coat protein; Region: Polyoma_coat2; cl17644 1401659005633 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1401659005634 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659005635 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1401659005636 dimerization interface [polypeptide binding]; other site 1401659005637 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1401659005638 MarR family; Region: MarR_2; cl17246 1401659005639 putative cyanate transporter; Provisional; Region: cynX; PRK09705 1401659005640 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1401659005641 active site 1401659005642 hypothetical protein; Provisional; Region: PRK10396 1401659005643 yecA family protein; Region: ygfB_yecA; TIGR02292 1401659005644 SEC-C motif; Region: SEC-C; pfam02810 1401659005645 GTP-binding protein YchF; Reviewed; Region: PRK09601 1401659005646 YchF GTPase; Region: YchF; cd01900 1401659005647 G1 box; other site 1401659005648 GTP/Mg2+ binding site [chemical binding]; other site 1401659005649 Switch I region; other site 1401659005650 G2 box; other site 1401659005651 Switch II region; other site 1401659005652 G3 box; other site 1401659005653 G4 box; other site 1401659005654 G5 box; other site 1401659005655 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1401659005656 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1401659005657 putative active site [active] 1401659005658 catalytic residue [active] 1401659005659 hypothetical protein; Provisional; Region: PRK10692 1401659005660 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 1401659005661 DNA binding residues [nucleotide binding] 1401659005662 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1401659005663 putative dimer interface [polypeptide binding]; other site 1401659005664 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1401659005665 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1401659005666 putative transporter; Provisional; Region: PRK11660 1401659005667 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1401659005668 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1401659005669 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1401659005670 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1401659005671 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1401659005672 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1401659005673 active site 1401659005674 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1401659005675 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1401659005676 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1401659005677 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 1401659005678 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1401659005679 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1401659005680 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1401659005681 tRNA; other site 1401659005682 putative tRNA binding site [nucleotide binding]; other site 1401659005683 putative NADP binding site [chemical binding]; other site 1401659005684 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1401659005685 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1401659005686 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1401659005687 RF-1 domain; Region: RF-1; pfam00472 1401659005688 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1401659005689 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1401659005690 Invasion gene expression up-regulator, SirB; Region: SirB; cl01184 1401659005691 hypothetical protein; Provisional; Region: PRK10941 1401659005692 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1401659005693 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1401659005694 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1401659005695 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 1401659005696 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1401659005697 cation transport regulator; Reviewed; Region: chaB; PRK09582 1401659005698 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 1401659005699 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1401659005700 putative active site pocket [active] 1401659005701 dimerization interface [polypeptide binding]; other site 1401659005702 putative catalytic residue [active] 1401659005703 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 1401659005704 Cache domain; Region: Cache_1; pfam02743 1401659005705 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1401659005706 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1401659005707 dimerization interface [polypeptide binding]; other site 1401659005708 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1401659005709 dimer interface [polypeptide binding]; other site 1401659005710 putative CheW interface [polypeptide binding]; other site 1401659005711 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 1401659005712 Nitrate and nitrite sensing; Region: NIT; pfam08376 1401659005713 ANTAR domain; Region: ANTAR; pfam03861 1401659005714 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1401659005715 NMT1-like family; Region: NMT1_2; pfam13379 1401659005716 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1401659005717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659005718 dimer interface [polypeptide binding]; other site 1401659005719 conserved gate region; other site 1401659005720 putative PBP binding loops; other site 1401659005721 ABC-ATPase subunit interface; other site 1401659005722 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1401659005723 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1401659005724 Walker A/P-loop; other site 1401659005725 ATP binding site [chemical binding]; other site 1401659005726 Q-loop/lid; other site 1401659005727 ABC transporter signature motif; other site 1401659005728 Walker B; other site 1401659005729 D-loop; other site 1401659005730 H-loop/switch region; other site 1401659005731 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1401659005732 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1401659005733 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1401659005734 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1401659005735 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1401659005736 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1401659005737 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1401659005738 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1401659005739 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1401659005740 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1401659005741 [4Fe-4S] binding site [ion binding]; other site 1401659005742 molybdopterin cofactor binding site; other site 1401659005743 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1401659005744 molybdopterin cofactor binding site; other site 1401659005745 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1401659005746 putative invasin; Provisional; Region: PRK10177 1401659005747 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1401659005748 transcriptional regulator NarL; Provisional; Region: PRK10651 1401659005749 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1401659005750 active site 1401659005751 phosphorylation site [posttranslational modification] 1401659005752 intermolecular recognition site; other site 1401659005753 dimerization interface [polypeptide binding]; other site 1401659005754 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1401659005755 DNA binding residues [nucleotide binding] 1401659005756 dimerization interface [polypeptide binding]; other site 1401659005757 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 1401659005758 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1401659005759 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1401659005760 dimerization interface [polypeptide binding]; other site 1401659005761 Histidine kinase; Region: HisKA_3; pfam07730 1401659005762 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1401659005763 ATP binding site [chemical binding]; other site 1401659005764 Mg2+ binding site [ion binding]; other site 1401659005765 G-X-G motif; other site 1401659005766 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1401659005767 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1401659005768 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1401659005769 [4Fe-4S] binding site [ion binding]; other site 1401659005770 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1401659005771 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1401659005772 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1401659005773 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1401659005774 molybdopterin cofactor binding site; other site 1401659005775 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1401659005776 4Fe-4S binding domain; Region: Fer4; cl02805 1401659005777 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1401659005778 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 1401659005779 Cupin; Region: Cupin_6; pfam12852 1401659005780 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1401659005781 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1401659005782 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1401659005783 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1401659005784 NAD(P) binding site [chemical binding]; other site 1401659005785 active site 1401659005786 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1401659005787 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1401659005788 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1401659005789 putative active site [active] 1401659005790 putative substrate binding site [chemical binding]; other site 1401659005791 putative cosubstrate binding site; other site 1401659005792 catalytic site [active] 1401659005793 hypothetical protein; Provisional; Region: PRK01617 1401659005794 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1401659005795 active site 1401659005796 response regulator of RpoS; Provisional; Region: PRK10693 1401659005797 phosphorylation site [posttranslational modification] 1401659005798 intermolecular recognition site; other site 1401659005799 dimerization interface [polypeptide binding]; other site 1401659005800 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1401659005801 active site 1401659005802 tetramer interface; other site 1401659005803 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1401659005804 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1401659005805 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1401659005806 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1401659005807 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1401659005808 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 1401659005809 putative NAD(P) binding site [chemical binding]; other site 1401659005810 active site 1401659005811 putative substrate binding site [chemical binding]; other site 1401659005812 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 1401659005813 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1401659005814 thymidine kinase; Provisional; Region: PRK04296 1401659005815 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1401659005816 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1401659005817 putative catalytic cysteine [active] 1401659005818 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1401659005819 putative active site [active] 1401659005820 metal binding site [ion binding]; metal-binding site 1401659005821 hypothetical protein; Provisional; Region: PRK11111 1401659005822 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1401659005823 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1401659005824 peptide binding site [polypeptide binding]; other site 1401659005825 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1401659005826 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659005827 dimer interface [polypeptide binding]; other site 1401659005828 conserved gate region; other site 1401659005829 putative PBP binding loops; other site 1401659005830 ABC-ATPase subunit interface; other site 1401659005831 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 1401659005832 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1401659005833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659005834 dimer interface [polypeptide binding]; other site 1401659005835 conserved gate region; other site 1401659005836 putative PBP binding loops; other site 1401659005837 ABC-ATPase subunit interface; other site 1401659005838 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 1401659005839 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1401659005840 Walker A/P-loop; other site 1401659005841 ATP binding site [chemical binding]; other site 1401659005842 Q-loop/lid; other site 1401659005843 ABC transporter signature motif; other site 1401659005844 Walker B; other site 1401659005845 D-loop; other site 1401659005846 H-loop/switch region; other site 1401659005847 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1401659005848 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1401659005849 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1401659005850 Walker A/P-loop; other site 1401659005851 ATP binding site [chemical binding]; other site 1401659005852 Q-loop/lid; other site 1401659005853 ABC transporter signature motif; other site 1401659005854 Walker B; other site 1401659005855 D-loop; other site 1401659005856 H-loop/switch region; other site 1401659005857 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1401659005858 Ion transport protein; Region: Ion_trans; pfam00520 1401659005859 Ion channel; Region: Ion_trans_2; pfam07885 1401659005860 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1401659005861 Double zinc ribbon; Region: DZR; pfam12773 1401659005862 dsDNA-mimic protein; Reviewed; Region: PRK05094 1401659005863 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1401659005864 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1401659005865 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 1401659005866 putative active site [active] 1401659005867 catalytic site [active] 1401659005868 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 1401659005869 putative active site [active] 1401659005870 catalytic site [active] 1401659005871 YciI-like protein; Reviewed; Region: PRK11370 1401659005872 transport protein TonB; Provisional; Region: PRK10819 1401659005873 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1401659005874 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1401659005875 outer membrane receptor FepA; Provisional; Region: PRK13528 1401659005876 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1401659005877 N-terminal plug; other site 1401659005878 ligand-binding site [chemical binding]; other site 1401659005879 intracellular septation protein A; Reviewed; Region: PRK00259 1401659005880 hypothetical protein; Provisional; Region: PRK02868 1401659005881 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 1401659005882 outer membrane protein W; Provisional; Region: PRK10959 1401659005883 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1401659005884 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1401659005885 substrate binding site [chemical binding]; other site 1401659005886 active site 1401659005887 catalytic residues [active] 1401659005888 heterodimer interface [polypeptide binding]; other site 1401659005889 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1401659005890 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1401659005891 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659005892 catalytic residue [active] 1401659005893 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 1401659005894 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1401659005895 active site 1401659005896 ribulose/triose binding site [chemical binding]; other site 1401659005897 phosphate binding site [ion binding]; other site 1401659005898 substrate (anthranilate) binding pocket [chemical binding]; other site 1401659005899 product (indole) binding pocket [chemical binding]; other site 1401659005900 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1401659005901 active site 1401659005902 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 1401659005903 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1401659005904 glutamine binding [chemical binding]; other site 1401659005905 catalytic triad [active] 1401659005906 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1401659005907 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1401659005908 anthranilate synthase component I; Provisional; Region: PRK13564 1401659005909 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1401659005910 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1401659005911 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1401659005912 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1401659005913 active site 1401659005914 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1401659005915 hypothetical protein; Provisional; Region: PRK11630 1401659005916 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 1401659005917 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1401659005918 RNA binding surface [nucleotide binding]; other site 1401659005919 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1401659005920 probable active site [active] 1401659005921 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1401659005922 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1401659005923 homodimer interface [polypeptide binding]; other site 1401659005924 Walker A motif; other site 1401659005925 ATP binding site [chemical binding]; other site 1401659005926 hydroxycobalamin binding site [chemical binding]; other site 1401659005927 Walker B motif; other site 1401659005928 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 1401659005929 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 1401659005930 NADP binding site [chemical binding]; other site 1401659005931 homodimer interface [polypeptide binding]; other site 1401659005932 active site 1401659005933 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 1401659005934 putative inner membrane peptidase; Provisional; Region: PRK11778 1401659005935 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1401659005936 tandem repeat interface [polypeptide binding]; other site 1401659005937 oligomer interface [polypeptide binding]; other site 1401659005938 active site residues [active] 1401659005939 hypothetical protein; Provisional; Region: PRK11037 1401659005940 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1401659005941 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1401659005942 active site 1401659005943 interdomain interaction site; other site 1401659005944 putative metal-binding site [ion binding]; other site 1401659005945 nucleotide binding site [chemical binding]; other site 1401659005946 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1401659005947 domain I; other site 1401659005948 DNA binding groove [nucleotide binding] 1401659005949 phosphate binding site [ion binding]; other site 1401659005950 domain II; other site 1401659005951 domain III; other site 1401659005952 nucleotide binding site [chemical binding]; other site 1401659005953 catalytic site [active] 1401659005954 domain IV; other site 1401659005955 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1401659005956 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1401659005957 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1401659005958 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1401659005959 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 1401659005960 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659005961 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 1401659005962 substrate binding site [chemical binding]; other site 1401659005963 putative dimerization interface [polypeptide binding]; other site 1401659005964 aconitate hydratase; Validated; Region: PRK09277 1401659005965 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1401659005966 substrate binding site [chemical binding]; other site 1401659005967 ligand binding site [chemical binding]; other site 1401659005968 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1401659005969 substrate binding site [chemical binding]; other site 1401659005970 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1401659005971 dimerization interface [polypeptide binding]; other site 1401659005972 active site 1401659005973 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1401659005974 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1401659005975 active site 1401659005976 Predicted membrane protein [Function unknown]; Region: COG3771 1401659005977 tetratricopeptide repeat protein; Provisional; Region: PRK11788 1401659005978 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1401659005979 TPR motif; other site 1401659005980 binding surface 1401659005981 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1401659005982 binding surface 1401659005983 TPR motif; other site 1401659005984 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1401659005985 active site 1401659005986 dimer interface [polypeptide binding]; other site 1401659005987 translation initiation factor Sui1; Validated; Region: PRK06824 1401659005988 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1401659005989 putative rRNA binding site [nucleotide binding]; other site 1401659005990 lipoprotein; Provisional; Region: PRK10540 1401659005991 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1401659005992 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1401659005993 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1401659005994 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 1401659005995 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1401659005996 dimer interface [polypeptide binding]; other site 1401659005997 active site 1401659005998 glycine loop; other site 1401659005999 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 1401659006000 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1401659006001 FeS/SAM binding site; other site 1401659006002 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1401659006003 active site 1401659006004 intersubunit interactions; other site 1401659006005 catalytic residue [active] 1401659006006 hypothetical protein; Provisional; Region: PRK13658 1401659006007 enoyl-CoA hydratase; Validated; Region: PRK08788 1401659006008 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1401659006009 substrate binding site [chemical binding]; other site 1401659006010 oxyanion hole (OAH) forming residues; other site 1401659006011 trimer interface [polypeptide binding]; other site 1401659006012 RNase II stability modulator; Provisional; Region: PRK10060 1401659006013 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1401659006014 putative active site [active] 1401659006015 heme pocket [chemical binding]; other site 1401659006016 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1401659006017 metal binding site [ion binding]; metal-binding site 1401659006018 active site 1401659006019 I-site; other site 1401659006020 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1401659006021 exoribonuclease II; Provisional; Region: PRK05054 1401659006022 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1401659006023 RNB domain; Region: RNB; pfam00773 1401659006024 S1 RNA binding domain; Region: S1; pfam00575 1401659006025 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 1401659006026 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1401659006027 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1401659006028 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 1401659006029 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1401659006030 NAD binding site [chemical binding]; other site 1401659006031 homotetramer interface [polypeptide binding]; other site 1401659006032 homodimer interface [polypeptide binding]; other site 1401659006033 substrate binding site [chemical binding]; other site 1401659006034 active site 1401659006035 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 1401659006036 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1401659006037 Walker A/P-loop; other site 1401659006038 ATP binding site [chemical binding]; other site 1401659006039 Q-loop/lid; other site 1401659006040 ABC transporter signature motif; other site 1401659006041 Walker B; other site 1401659006042 D-loop; other site 1401659006043 H-loop/switch region; other site 1401659006044 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1401659006045 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 1401659006046 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1401659006047 Walker A/P-loop; other site 1401659006048 ATP binding site [chemical binding]; other site 1401659006049 Q-loop/lid; other site 1401659006050 ABC transporter signature motif; other site 1401659006051 Walker B; other site 1401659006052 D-loop; other site 1401659006053 H-loop/switch region; other site 1401659006054 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1401659006055 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 1401659006056 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1401659006057 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659006058 putative PBP binding loops; other site 1401659006059 dimer interface [polypeptide binding]; other site 1401659006060 ABC-ATPase subunit interface; other site 1401659006061 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 1401659006062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659006063 dimer interface [polypeptide binding]; other site 1401659006064 conserved gate region; other site 1401659006065 putative PBP binding loops; other site 1401659006066 ABC-ATPase subunit interface; other site 1401659006067 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1401659006068 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1401659006069 peptide binding site [polypeptide binding]; other site 1401659006070 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 1401659006071 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1401659006072 Walker A motif; other site 1401659006073 ATP binding site [chemical binding]; other site 1401659006074 Walker B motif; other site 1401659006075 arginine finger; other site 1401659006076 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1401659006077 phage shock protein PspA; Provisional; Region: PRK10698 1401659006078 phage shock protein B; Provisional; Region: pspB; PRK09458 1401659006079 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 1401659006080 phage shock protein C; Region: phageshock_pspC; TIGR02978 1401659006081 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 1401659006082 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 1401659006083 sucrose phosphorylase; Provisional; Region: PRK13840 1401659006084 active site 1401659006085 homodimer interface [polypeptide binding]; other site 1401659006086 catalytic site [active] 1401659006087 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1401659006088 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1401659006089 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1401659006090 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1401659006091 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659006092 dimer interface [polypeptide binding]; other site 1401659006093 conserved gate region; other site 1401659006094 putative PBP binding loops; other site 1401659006095 ABC-ATPase subunit interface; other site 1401659006096 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1401659006097 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659006098 dimer interface [polypeptide binding]; other site 1401659006099 conserved gate region; other site 1401659006100 putative PBP binding loops; other site 1401659006101 ABC-ATPase subunit interface; other site 1401659006102 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1401659006103 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 1401659006104 putative NAD(P) binding site [chemical binding]; other site 1401659006105 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1401659006106 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1401659006107 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1401659006108 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1401659006109 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1401659006110 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1401659006111 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1401659006112 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1401659006113 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1401659006114 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1401659006115 motif II; other site 1401659006116 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1401659006117 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1401659006118 Walker A/P-loop; other site 1401659006119 ATP binding site [chemical binding]; other site 1401659006120 Q-loop/lid; other site 1401659006121 ABC transporter signature motif; other site 1401659006122 Walker B; other site 1401659006123 D-loop; other site 1401659006124 H-loop/switch region; other site 1401659006125 TOBE domain; Region: TOBE_2; pfam08402 1401659006126 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1401659006127 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1401659006128 DNA binding site [nucleotide binding] 1401659006129 domain linker motif; other site 1401659006130 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1401659006131 Predicted ATPase [General function prediction only]; Region: COG3106 1401659006132 hypothetical protein; Provisional; Region: PRK05415 1401659006133 Domain of unknown function (DUF697); Region: DUF697; cl12064 1401659006134 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 1401659006135 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 1401659006136 putative aromatic amino acid binding site; other site 1401659006137 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1401659006138 putative active site [active] 1401659006139 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1401659006140 Walker A motif; other site 1401659006141 ATP binding site [chemical binding]; other site 1401659006142 Walker B motif; other site 1401659006143 arginine finger; other site 1401659006144 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1401659006145 dimer interface [polypeptide binding]; other site 1401659006146 catalytic triad [active] 1401659006147 peroxidatic and resolving cysteines [active] 1401659006148 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 1401659006149 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1401659006150 active site 1401659006151 murein peptide amidase A; Provisional; Region: PRK10602 1401659006152 active site 1401659006153 Zn binding site [ion binding]; other site 1401659006154 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1401659006155 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1401659006156 peptide binding site [polypeptide binding]; other site 1401659006157 anti-adapter protein IraM; Provisional; Region: PRK09919 1401659006158 General stress protein [General function prediction only]; Region: GsiB; COG3729 1401659006159 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1401659006160 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1401659006161 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 1401659006162 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1401659006163 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1401659006164 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 1401659006165 Cl binding site [ion binding]; other site 1401659006166 oligomer interface [polypeptide binding]; other site 1401659006167 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1401659006168 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1401659006169 Ligand Binding Site [chemical binding]; other site 1401659006170 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1401659006171 putative catalytic site [active] 1401659006172 putative metal binding site [ion binding]; other site 1401659006173 putative phosphate binding site [ion binding]; other site 1401659006174 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1401659006175 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1401659006176 NAD binding site [chemical binding]; other site 1401659006177 metal binding site [ion binding]; metal-binding site 1401659006178 active site 1401659006179 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1401659006180 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1401659006181 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1401659006182 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1401659006183 Walker A motif; other site 1401659006184 ATP binding site [chemical binding]; other site 1401659006185 Walker B motif; other site 1401659006186 arginine finger; other site 1401659006187 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1401659006188 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1401659006189 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1401659006190 NAD(P) binding site [chemical binding]; other site 1401659006191 catalytic residues [active] 1401659006192 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1401659006193 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1401659006194 NAD binding site [chemical binding]; other site 1401659006195 substrate binding site [chemical binding]; other site 1401659006196 catalytic Zn binding site [ion binding]; other site 1401659006197 tetramer interface [polypeptide binding]; other site 1401659006198 structural Zn binding site [ion binding]; other site 1401659006199 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1401659006200 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1401659006201 dimer interface [polypeptide binding]; other site 1401659006202 PYR/PP interface [polypeptide binding]; other site 1401659006203 TPP binding site [chemical binding]; other site 1401659006204 substrate binding site [chemical binding]; other site 1401659006205 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1401659006206 Domain of unknown function; Region: EKR; smart00890 1401659006207 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1401659006208 4Fe-4S binding domain; Region: Fer4; pfam00037 1401659006209 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1401659006210 TPP-binding site [chemical binding]; other site 1401659006211 dimer interface [polypeptide binding]; other site 1401659006212 Domain of unknown function (DUF333); Region: DUF333; pfam03891 1401659006213 META domain; Region: META; cl01245 1401659006214 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 1401659006215 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1401659006216 putative ligand binding site [chemical binding]; other site 1401659006217 putative NAD binding site [chemical binding]; other site 1401659006218 catalytic site [active] 1401659006219 hypothetical protein; Provisional; Region: PRK10695 1401659006220 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 1401659006221 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 1401659006222 azoreductase; Reviewed; Region: PRK00170 1401659006223 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1401659006224 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1401659006225 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1401659006226 ATP binding site [chemical binding]; other site 1401659006227 putative Mg++ binding site [ion binding]; other site 1401659006228 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1401659006229 nucleotide binding region [chemical binding]; other site 1401659006230 ATP-binding site [chemical binding]; other site 1401659006231 Helicase associated domain (HA2); Region: HA2; pfam04408 1401659006232 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1401659006233 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1401659006234 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 1401659006235 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1401659006236 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1401659006237 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1401659006238 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1401659006239 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1401659006240 HlyD family secretion protein; Region: HlyD_3; pfam13437 1401659006241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659006242 putative substrate translocation pore; other site 1401659006243 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1401659006244 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1401659006245 MarR family; Region: MarR_2; pfam12802 1401659006246 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1401659006247 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1401659006248 Coenzyme A binding pocket [chemical binding]; other site 1401659006249 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 1401659006250 FosA, a Fosfomycin resistance protein, catalyzes the addition of glutathione to the antibiotic fosfomycin, making it inactive; Region: FosA; cd07244 1401659006251 dimer interface [polypeptide binding]; other site 1401659006252 Mn binding site [ion binding]; other site 1401659006253 K binding site [ion binding]; other site 1401659006254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659006255 metabolite-proton symporter; Region: 2A0106; TIGR00883 1401659006256 putative substrate translocation pore; other site 1401659006257 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1401659006258 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1401659006259 putative active site [active] 1401659006260 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 1401659006261 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1401659006262 NAD binding site [chemical binding]; other site 1401659006263 catalytic residues [active] 1401659006264 substrate binding site [chemical binding]; other site 1401659006265 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1401659006266 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1401659006267 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1401659006268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659006269 metabolite-proton symporter; Region: 2A0106; TIGR00883 1401659006270 putative substrate translocation pore; other site 1401659006271 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1401659006272 putative metal binding site [ion binding]; other site 1401659006273 putative homodimer interface [polypeptide binding]; other site 1401659006274 putative homotetramer interface [polypeptide binding]; other site 1401659006275 putative homodimer-homodimer interface [polypeptide binding]; other site 1401659006276 putative allosteric switch controlling residues; other site 1401659006277 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1401659006278 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1401659006279 substrate binding site [chemical binding]; other site 1401659006280 catalytic Zn binding site [ion binding]; other site 1401659006281 NAD binding site [chemical binding]; other site 1401659006282 structural Zn binding site [ion binding]; other site 1401659006283 dimer interface [polypeptide binding]; other site 1401659006284 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 1401659006285 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1401659006286 dimer interface [polypeptide binding]; other site 1401659006287 ligand binding site [chemical binding]; other site 1401659006288 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1401659006289 dimerization interface [polypeptide binding]; other site 1401659006290 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1401659006291 dimer interface [polypeptide binding]; other site 1401659006292 putative CheW interface [polypeptide binding]; other site 1401659006293 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 1401659006294 dimerization interface [polypeptide binding]; other site 1401659006295 metal binding site [ion binding]; metal-binding site 1401659006296 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1401659006297 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1401659006298 FMN binding site [chemical binding]; other site 1401659006299 active site 1401659006300 substrate binding site [chemical binding]; other site 1401659006301 catalytic residue [active] 1401659006302 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1401659006303 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659006304 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1401659006305 dimerization interface [polypeptide binding]; other site 1401659006306 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 1401659006307 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1401659006308 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1401659006309 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1401659006310 substrate binding pocket [chemical binding]; other site 1401659006311 catalytic triad [active] 1401659006312 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 1401659006313 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 1401659006314 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1401659006315 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1401659006316 Coenzyme A binding pocket [chemical binding]; other site 1401659006317 UDP-3-O-[3-hydroxymyristoyl]; Region: LpxD; COG1044 1401659006318 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 1401659006319 putative trimer interface [polypeptide binding]; other site 1401659006320 putative CoA binding site [chemical binding]; other site 1401659006321 tellurite resistance protein TehB; Provisional; Region: PRK11207 1401659006322 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1401659006323 S-adenosylmethionine binding site [chemical binding]; other site 1401659006324 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 1401659006325 integrase; Provisional; Region: PRK09692 1401659006326 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1401659006327 active site 1401659006328 Int/Topo IB signature motif; other site 1401659006329 MT-A70; Region: MT-A70; cl01947 1401659006330 Protein of unknown function (DUF1317); Region: DUF1317; pfam07026 1401659006331 PerC transcriptional activator; Region: PerC; pfam06069 1401659006332 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1401659006333 RecT family; Region: RecT; pfam03837 1401659006334 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 1401659006335 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1401659006336 non-specific DNA binding site [nucleotide binding]; other site 1401659006337 salt bridge; other site 1401659006338 sequence-specific DNA binding site [nucleotide binding]; other site 1401659006339 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1401659006340 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1401659006341 non-specific DNA binding site [nucleotide binding]; other site 1401659006342 salt bridge; other site 1401659006343 sequence-specific DNA binding site [nucleotide binding]; other site 1401659006344 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1401659006345 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1401659006346 cofactor binding site; other site 1401659006347 DNA binding site [nucleotide binding] 1401659006348 substrate interaction site [chemical binding]; other site 1401659006349 primosomal protein DnaI; Provisional; Region: PRK02854 1401659006350 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 1401659006351 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1401659006352 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1401659006353 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 1401659006354 Terminase small subunit; Region: Terminase_2; pfam03592 1401659006355 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1401659006356 hypothetical protein; Region: PHA00670 1401659006357 Bacteriophage head to tail connecting protein; Region: Head-tail_con; pfam12236 1401659006358 putative protease; Region: PHA00666 1401659006359 major capsid protein; Region: PHA00665 1401659006360 hypothetical protein; Region: PHA00664 1401659006361 hypothetical protein; Region: PHA00662 1401659006362 hypothetical protein; Region: PHA00661 1401659006363 hypothetical protein; Region: PHA01733 1401659006364 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1401659006365 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1401659006366 catalytic residue [active] 1401659006367 structural protein; Region: PHA01972 1401659006368 BRO family, N-terminal domain; Region: Bro-N; smart01040 1401659006369 Phage T7 tail fibre protein; Region: Phage_T7_tail; pfam03906 1401659006370 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1401659006371 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 1401659006372 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1401659006373 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1401659006374 Ligand binding site; other site 1401659006375 Putative Catalytic site; other site 1401659006376 DXD motif; other site 1401659006377 Predicted chitinase [General function prediction only]; Region: COG3179 1401659006378 catalytic residue [active] 1401659006379 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 1401659006380 benzoate transporter; Region: benE; TIGR00843 1401659006381 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 1401659006382 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1401659006383 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1401659006384 non-specific DNA binding site [nucleotide binding]; other site 1401659006385 salt bridge; other site 1401659006386 sequence-specific DNA binding site [nucleotide binding]; other site 1401659006387 Cupin domain; Region: Cupin_2; pfam07883 1401659006388 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1401659006389 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1401659006390 Peptidase family U32; Region: Peptidase_U32; pfam01136 1401659006391 Collagenase; Region: DUF3656; pfam12392 1401659006392 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1401659006393 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1401659006394 Catalytic site [active] 1401659006395 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1401659006396 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1401659006397 active site 1401659006398 DNA binding site [nucleotide binding] 1401659006399 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1401659006400 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 1401659006401 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 1401659006402 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 1401659006403 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1401659006404 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1401659006405 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1401659006406 active site 1401659006407 Zn binding site [ion binding]; other site 1401659006408 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1401659006409 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659006410 putative substrate translocation pore; other site 1401659006411 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1401659006412 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659006413 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1401659006414 dimerization interface [polypeptide binding]; other site 1401659006415 substrate binding pocket [chemical binding]; other site 1401659006416 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1401659006417 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1401659006418 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1401659006419 putative dithiobiotin synthetase; Provisional; Region: PRK12374 1401659006420 AAA domain; Region: AAA_26; pfam13500 1401659006421 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1401659006422 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1401659006423 Walker A/P-loop; other site 1401659006424 ATP binding site [chemical binding]; other site 1401659006425 Q-loop/lid; other site 1401659006426 ABC transporter signature motif; other site 1401659006427 Walker B; other site 1401659006428 D-loop; other site 1401659006429 H-loop/switch region; other site 1401659006430 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 1401659006431 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659006432 dimer interface [polypeptide binding]; other site 1401659006433 conserved gate region; other site 1401659006434 ABC-ATPase subunit interface; other site 1401659006435 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1401659006436 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1401659006437 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659006438 dimer interface [polypeptide binding]; other site 1401659006439 conserved gate region; other site 1401659006440 putative PBP binding loops; other site 1401659006441 ABC-ATPase subunit interface; other site 1401659006442 GlpM protein; Region: GlpM; pfam06942 1401659006443 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 1401659006444 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 1401659006445 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1401659006446 4Fe-4S binding domain; Region: Fer4; pfam00037 1401659006447 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 1401659006448 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1401659006449 putative [Fe4-S4] binding site [ion binding]; other site 1401659006450 putative molybdopterin cofactor binding site [chemical binding]; other site 1401659006451 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1401659006452 putative molybdopterin cofactor binding site; other site 1401659006453 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 1401659006454 Uncharacterized protein family (UPF0257); Region: UPF0257; cl14672 1401659006455 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 1401659006456 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1401659006457 Coenzyme A binding pocket [chemical binding]; other site 1401659006458 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1401659006459 hypothetical protein; Provisional; Region: PRK13659 1401659006460 hypothetical protein; Provisional; Region: PRK02237 1401659006461 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 1401659006462 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 1401659006463 putative active site pocket [active] 1401659006464 putative metal binding site [ion binding]; other site 1401659006465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659006466 D-galactonate transporter; Region: 2A0114; TIGR00893 1401659006467 putative substrate translocation pore; other site 1401659006468 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1401659006469 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1401659006470 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1401659006471 YdfZ protein; Region: YdfZ; pfam14001 1401659006472 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1401659006473 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1401659006474 DNA-binding site [nucleotide binding]; DNA binding site 1401659006475 FCD domain; Region: FCD; pfam07729 1401659006476 malonic semialdehyde reductase; Provisional; Region: PRK10538 1401659006477 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 1401659006478 putative NAD(P) binding site [chemical binding]; other site 1401659006479 homodimer interface [polypeptide binding]; other site 1401659006480 homotetramer interface [polypeptide binding]; other site 1401659006481 active site 1401659006482 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 1401659006483 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1401659006484 active site 1401659006485 Zn binding site [ion binding]; other site 1401659006486 transcriptional regulator MirA; Provisional; Region: PRK15043 1401659006487 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1401659006488 DNA binding residues [nucleotide binding] 1401659006489 dimer interface [polypeptide binding]; other site 1401659006490 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 1401659006491 Protein of unknown function (DUF1264); Region: DUF1264; pfam06884 1401659006492 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1401659006493 substrate binding site [chemical binding]; other site 1401659006494 THF binding site; other site 1401659006495 zinc-binding site [ion binding]; other site 1401659006496 allophanate hydrolase; Provisional; Region: PRK08186 1401659006497 Amidase; Region: Amidase; pfam01425 1401659006498 urea carboxylase; Region: urea_carbox; TIGR02712 1401659006499 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1401659006500 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1401659006501 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1401659006502 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1401659006503 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1401659006504 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1401659006505 carboxyltransferase (CT) interaction site; other site 1401659006506 biotinylation site [posttranslational modification]; other site 1401659006507 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1401659006508 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1401659006509 DNA-binding site [nucleotide binding]; DNA binding site 1401659006510 FCD domain; Region: FCD; pfam07729 1401659006511 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1401659006512 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1401659006513 putative ligand binding site [chemical binding]; other site 1401659006514 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1401659006515 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1401659006516 TM-ABC transporter signature motif; other site 1401659006517 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1401659006518 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1401659006519 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1401659006520 TM-ABC transporter signature motif; other site 1401659006521 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1401659006522 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1401659006523 Walker A/P-loop; other site 1401659006524 ATP binding site [chemical binding]; other site 1401659006525 Q-loop/lid; other site 1401659006526 ABC transporter signature motif; other site 1401659006527 Walker B; other site 1401659006528 D-loop; other site 1401659006529 H-loop/switch region; other site 1401659006530 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1401659006531 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1401659006532 Walker A/P-loop; other site 1401659006533 ATP binding site [chemical binding]; other site 1401659006534 Q-loop/lid; other site 1401659006535 ABC transporter signature motif; other site 1401659006536 Walker B; other site 1401659006537 D-loop; other site 1401659006538 H-loop/switch region; other site 1401659006539 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1401659006540 ABC transporter signature motif; other site 1401659006541 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1401659006542 putative transporter; Provisional; Region: PRK10054 1401659006543 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659006544 putative substrate translocation pore; other site 1401659006545 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1401659006546 EamA-like transporter family; Region: EamA; pfam00892 1401659006547 hypothetical protein; Provisional; Region: PRK10106 1401659006548 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1401659006549 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1401659006550 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1401659006551 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 1401659006552 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1401659006553 putative arabinose transporter; Provisional; Region: PRK03545 1401659006554 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659006555 putative substrate translocation pore; other site 1401659006556 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1401659006557 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1401659006558 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1401659006559 NAD binding site [chemical binding]; other site 1401659006560 dimer interface [polypeptide binding]; other site 1401659006561 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1401659006562 substrate binding site [chemical binding]; other site 1401659006563 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1401659006564 Coenzyme A binding pocket [chemical binding]; other site 1401659006565 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1401659006566 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659006567 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1401659006568 putative dimerization interface [polypeptide binding]; other site 1401659006569 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 1401659006570 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1401659006571 NAD(P) binding site [chemical binding]; other site 1401659006572 catalytic residues [active] 1401659006573 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1401659006574 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1401659006575 dimer interface [polypeptide binding]; other site 1401659006576 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1401659006577 dimerization interface [polypeptide binding]; other site 1401659006578 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1401659006579 dimer interface [polypeptide binding]; other site 1401659006580 putative CheW interface [polypeptide binding]; other site 1401659006581 glutaminase; Provisional; Region: PRK00971 1401659006582 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1401659006583 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 1401659006584 MASE1; Region: MASE1; cl17823 1401659006585 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1401659006586 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1401659006587 metal binding site [ion binding]; metal-binding site 1401659006588 active site 1401659006589 I-site; other site 1401659006590 MASE2 domain; Region: MASE2; pfam05230 1401659006591 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1401659006592 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1401659006593 metal binding site [ion binding]; metal-binding site 1401659006594 active site 1401659006595 I-site; other site 1401659006596 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1401659006597 GAF domain; Region: GAF; pfam01590 1401659006598 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1401659006599 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1401659006600 metal binding site [ion binding]; metal-binding site 1401659006601 active site 1401659006602 I-site; other site 1401659006603 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1401659006604 Coenzyme A binding pocket [chemical binding]; other site 1401659006605 altronate oxidoreductase; Provisional; Region: PRK03643 1401659006606 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1401659006607 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1401659006608 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 1401659006609 active site 1401659006610 catalytic triad [active] 1401659006611 oxyanion hole [active] 1401659006612 Autotransporter beta-domain; Region: Autotransporter; cl17461 1401659006613 trehalase; Provisional; Region: treF; PRK13270 1401659006614 Trehalase; Region: Trehalase; cl17346 1401659006615 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1401659006616 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1401659006617 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1401659006618 PAS fold; Region: PAS_7; pfam12860 1401659006619 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1401659006620 PAS fold; Region: PAS_3; pfam08447 1401659006621 putative active site [active] 1401659006622 heme pocket [chemical binding]; other site 1401659006623 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1401659006624 dimer interface [polypeptide binding]; other site 1401659006625 phosphorylation site [posttranslational modification] 1401659006626 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1401659006627 ATP binding site [chemical binding]; other site 1401659006628 Mg2+ binding site [ion binding]; other site 1401659006629 G-X-G motif; other site 1401659006630 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1401659006631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1401659006632 active site 1401659006633 phosphorylation site [posttranslational modification] 1401659006634 intermolecular recognition site; other site 1401659006635 dimerization interface [polypeptide binding]; other site 1401659006636 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1401659006637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1401659006638 active site 1401659006639 phosphorylation site [posttranslational modification] 1401659006640 intermolecular recognition site; other site 1401659006641 dimerization interface [polypeptide binding]; other site 1401659006642 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 1401659006643 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 1401659006644 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 1401659006645 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1401659006646 DXD motif; other site 1401659006647 OpgC protein; Region: OpgC_C; cl17858 1401659006648 Response regulator receiver domain; Region: Response_reg; pfam00072 1401659006649 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1401659006650 active site 1401659006651 phosphorylation site [posttranslational modification] 1401659006652 intermolecular recognition site; other site 1401659006653 dimerization interface [polypeptide binding]; other site 1401659006654 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1401659006655 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1401659006656 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1401659006657 anti sigma factor interaction site; other site 1401659006658 regulatory phosphorylation site [posttranslational modification]; other site 1401659006659 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1401659006660 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1401659006661 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1401659006662 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1401659006663 non-specific DNA binding site [nucleotide binding]; other site 1401659006664 salt bridge; other site 1401659006665 sequence-specific DNA binding site [nucleotide binding]; other site 1401659006666 Cupin domain; Region: Cupin_2; pfam07883 1401659006667 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1401659006668 B3/4 domain; Region: B3_4; pfam03483 1401659006669 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1401659006670 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1401659006671 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1401659006672 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659006673 putative substrate translocation pore; other site 1401659006674 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1401659006675 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659006676 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1401659006677 putative effector binding pocket; other site 1401659006678 dimerization interface [polypeptide binding]; other site 1401659006679 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1401659006680 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1401659006681 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 1401659006682 DNA binding residues [nucleotide binding] 1401659006683 putative dimer interface [polypeptide binding]; other site 1401659006684 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1401659006685 NlpC/P60 family; Region: NLPC_P60; pfam00877 1401659006686 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1401659006687 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 1401659006688 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1401659006689 EAL domain; Region: EAL; pfam00563 1401659006690 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1401659006691 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659006692 putative substrate translocation pore; other site 1401659006693 UV-endonuclease UvdE; Region: UvdE; cl10036 1401659006694 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1401659006695 RHS Repeat; Region: RHS_repeat; pfam05593 1401659006696 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1401659006697 RHS Repeat; Region: RHS_repeat; cl11982 1401659006698 RHS Repeat; Region: RHS_repeat; cl11982 1401659006699 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1401659006700 RHS Repeat; Region: RHS_repeat; pfam05593 1401659006701 RHS protein; Region: RHS; pfam03527 1401659006702 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1401659006703 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1401659006704 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1401659006705 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1401659006706 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 1401659006707 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1401659006708 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1401659006709 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1401659006710 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1401659006711 classical (c) SDRs; Region: SDR_c; cd05233 1401659006712 NAD(P) binding site [chemical binding]; other site 1401659006713 active site 1401659006714 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 1401659006715 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1401659006716 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1401659006717 TfoX N-terminal domain; Region: TfoX_N; pfam04993 1401659006718 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1401659006719 classical (c) SDRs; Region: SDR_c; cd05233 1401659006720 NAD(P) binding site [chemical binding]; other site 1401659006721 active site 1401659006722 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1401659006723 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1401659006724 putative NAD(P) binding site [chemical binding]; other site 1401659006725 putative substrate binding site [chemical binding]; other site 1401659006726 catalytic Zn binding site [ion binding]; other site 1401659006727 structural Zn binding site [ion binding]; other site 1401659006728 dimer interface [polypeptide binding]; other site 1401659006729 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1401659006730 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1401659006731 Cupin; Region: Cupin_6; pfam12852 1401659006732 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1401659006733 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1401659006734 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1401659006735 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1401659006736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 1401659006737 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1401659006738 dimanganese center [ion binding]; other site 1401659006739 4-oxalocrotonate tautomerase; Provisional; Region: PRK01271 1401659006740 active site 1 [active] 1401659006741 dimer interface [polypeptide binding]; other site 1401659006742 hexamer interface [polypeptide binding]; other site 1401659006743 active site 2 [active] 1401659006744 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1401659006745 dimer interface [polypeptide binding]; other site 1401659006746 FMN binding site [chemical binding]; other site 1401659006747 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 1401659006748 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1401659006749 L-asparagine permease; Provisional; Region: PRK15049 1401659006750 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 1401659006751 NMT1-like family; Region: NMT1_2; pfam13379 1401659006752 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1401659006753 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1401659006754 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1401659006755 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1401659006756 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1401659006757 Walker A/P-loop; other site 1401659006758 ATP binding site [chemical binding]; other site 1401659006759 Q-loop/lid; other site 1401659006760 ABC transporter signature motif; other site 1401659006761 Walker B; other site 1401659006762 D-loop; other site 1401659006763 H-loop/switch region; other site 1401659006764 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1401659006765 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659006766 dimer interface [polypeptide binding]; other site 1401659006767 conserved gate region; other site 1401659006768 putative PBP binding loops; other site 1401659006769 ABC-ATPase subunit interface; other site 1401659006770 PQQ-like domain; Region: PQQ_2; pfam13360 1401659006771 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1401659006772 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1401659006773 N-terminal plug; other site 1401659006774 ligand-binding site [chemical binding]; other site 1401659006775 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1401659006776 non-specific DNA binding site [nucleotide binding]; other site 1401659006777 salt bridge; other site 1401659006778 sequence-specific DNA binding site [nucleotide binding]; other site 1401659006779 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 1401659006780 trehalose synthase; Region: treS_nterm; TIGR02456 1401659006781 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1401659006782 active site 1401659006783 catalytic site [active] 1401659006784 short chain dehydrogenase; Provisional; Region: PRK07109 1401659006785 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 1401659006786 putative NAD(P) binding site [chemical binding]; other site 1401659006787 active site 1401659006788 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1401659006789 dimerization interface [polypeptide binding]; other site 1401659006790 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1401659006791 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1401659006792 dimer interface [polypeptide binding]; other site 1401659006793 putative CheW interface [polypeptide binding]; other site 1401659006794 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 1401659006795 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1401659006796 DNA-binding site [nucleotide binding]; DNA binding site 1401659006797 FCD domain; Region: FCD; pfam07729 1401659006798 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 1401659006799 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1401659006800 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1401659006801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659006802 dimer interface [polypeptide binding]; other site 1401659006803 conserved gate region; other site 1401659006804 putative PBP binding loops; other site 1401659006805 ABC-ATPase subunit interface; other site 1401659006806 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1401659006807 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659006808 dimer interface [polypeptide binding]; other site 1401659006809 conserved gate region; other site 1401659006810 putative PBP binding loops; other site 1401659006811 ABC-ATPase subunit interface; other site 1401659006812 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 1401659006813 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1401659006814 metal binding site [ion binding]; metal-binding site 1401659006815 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 1401659006816 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1401659006817 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1401659006818 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1401659006819 Walker A/P-loop; other site 1401659006820 ATP binding site [chemical binding]; other site 1401659006821 Q-loop/lid; other site 1401659006822 ABC transporter signature motif; other site 1401659006823 Walker B; other site 1401659006824 D-loop; other site 1401659006825 H-loop/switch region; other site 1401659006826 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1401659006827 Walker A/P-loop; other site 1401659006828 ATP binding site [chemical binding]; other site 1401659006829 Q-loop/lid; other site 1401659006830 ABC transporter signature motif; other site 1401659006831 Walker B; other site 1401659006832 D-loop; other site 1401659006833 H-loop/switch region; other site 1401659006834 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1401659006835 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1401659006836 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1401659006837 NAD(P) binding site [chemical binding]; other site 1401659006838 substrate binding site [chemical binding]; other site 1401659006839 dimer interface [polypeptide binding]; other site 1401659006840 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1401659006841 non-specific DNA binding site [nucleotide binding]; other site 1401659006842 salt bridge; other site 1401659006843 sequence-specific DNA binding site [nucleotide binding]; other site 1401659006844 Cupin domain; Region: Cupin_2; pfam07883 1401659006845 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1401659006846 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1401659006847 Coenzyme A binding pocket [chemical binding]; other site 1401659006848 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1401659006849 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1401659006850 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1401659006851 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 1401659006852 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1401659006853 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1401659006854 peptide binding site [polypeptide binding]; other site 1401659006855 Virulence factor SrfB; Region: SrfB; pfam07520 1401659006856 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458 1401659006857 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 1401659006858 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1401659006859 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1401659006860 Metal-binding active site; metal-binding site 1401659006861 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1401659006862 Tar ligand binding domain homologue; Region: TarH; pfam02203 1401659006863 dimer interface [polypeptide binding]; other site 1401659006864 ligand binding site [chemical binding]; other site 1401659006865 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1401659006866 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1401659006867 dimerization interface [polypeptide binding]; other site 1401659006868 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1401659006869 dimer interface [polypeptide binding]; other site 1401659006870 putative CheW interface [polypeptide binding]; other site 1401659006871 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1401659006872 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1401659006873 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1401659006874 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 1401659006875 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1401659006876 4Fe-4S binding domain; Region: Fer4; pfam00037 1401659006877 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1401659006878 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1401659006879 putative [Fe4-S4] binding site [ion binding]; other site 1401659006880 putative molybdopterin cofactor binding site [chemical binding]; other site 1401659006881 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1401659006882 putative molybdopterin cofactor binding site; other site 1401659006883 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1401659006884 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1401659006885 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1401659006886 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1401659006887 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1401659006888 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1401659006889 Coenzyme A binding pocket [chemical binding]; other site 1401659006890 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1401659006891 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1401659006892 tetrameric interface [polypeptide binding]; other site 1401659006893 NAD binding site [chemical binding]; other site 1401659006894 catalytic residues [active] 1401659006895 substrate binding site [chemical binding]; other site 1401659006896 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1401659006897 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659006898 putative PBP binding loops; other site 1401659006899 dimer interface [polypeptide binding]; other site 1401659006900 ABC-ATPase subunit interface; other site 1401659006901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659006902 dimer interface [polypeptide binding]; other site 1401659006903 conserved gate region; other site 1401659006904 putative PBP binding loops; other site 1401659006905 ABC-ATPase subunit interface; other site 1401659006906 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1401659006907 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1401659006908 Walker A/P-loop; other site 1401659006909 ATP binding site [chemical binding]; other site 1401659006910 Q-loop/lid; other site 1401659006911 ABC transporter signature motif; other site 1401659006912 Walker B; other site 1401659006913 D-loop; other site 1401659006914 H-loop/switch region; other site 1401659006915 TOBE domain; Region: TOBE_2; pfam08402 1401659006916 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1401659006917 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1401659006918 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1401659006919 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1401659006920 DNA-binding site [nucleotide binding]; DNA binding site 1401659006921 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1401659006922 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659006923 homodimer interface [polypeptide binding]; other site 1401659006924 catalytic residue [active] 1401659006925 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1401659006926 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1401659006927 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1401659006928 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1401659006929 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 1401659006930 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1401659006931 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1401659006932 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1401659006933 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1401659006934 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1401659006935 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1401659006936 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1401659006937 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1401659006938 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 1401659006939 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1401659006940 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659006941 dimer interface [polypeptide binding]; other site 1401659006942 conserved gate region; other site 1401659006943 ABC-ATPase subunit interface; other site 1401659006944 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1401659006945 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659006946 putative PBP binding loops; other site 1401659006947 dimer interface [polypeptide binding]; other site 1401659006948 ABC-ATPase subunit interface; other site 1401659006949 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1401659006950 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1401659006951 Walker A/P-loop; other site 1401659006952 ATP binding site [chemical binding]; other site 1401659006953 Q-loop/lid; other site 1401659006954 ABC transporter signature motif; other site 1401659006955 Walker B; other site 1401659006956 D-loop; other site 1401659006957 H-loop/switch region; other site 1401659006958 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1401659006959 Walker A/P-loop; other site 1401659006960 ATP binding site [chemical binding]; other site 1401659006961 Q-loop/lid; other site 1401659006962 ABC transporter signature motif; other site 1401659006963 Walker B; other site 1401659006964 D-loop; other site 1401659006965 H-loop/switch region; other site 1401659006966 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1401659006967 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 1401659006968 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1401659006969 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 1401659006970 alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030 1401659006971 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1401659006972 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1401659006973 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1401659006974 active site 1401659006975 motif I; other site 1401659006976 motif II; other site 1401659006977 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1401659006978 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1401659006979 Smr domain; Region: Smr; pfam01713 1401659006980 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 1401659006981 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1401659006982 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1401659006983 DNA binding site [nucleotide binding] 1401659006984 active site 1401659006985 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1401659006986 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1401659006987 ligand binding site [chemical binding]; other site 1401659006988 flexible hinge region; other site 1401659006989 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1401659006990 putative switch regulator; other site 1401659006991 non-specific DNA interactions [nucleotide binding]; other site 1401659006992 DNA binding site [nucleotide binding] 1401659006993 sequence specific DNA binding site [nucleotide binding]; other site 1401659006994 putative cAMP binding site [chemical binding]; other site 1401659006995 universal stress protein UspE; Provisional; Region: PRK11175 1401659006996 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1401659006997 Ligand Binding Site [chemical binding]; other site 1401659006998 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1401659006999 Ligand Binding Site [chemical binding]; other site 1401659007000 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 1401659007001 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1401659007002 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 1401659007003 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1401659007004 ligand binding site [chemical binding]; other site 1401659007005 homodimer interface [polypeptide binding]; other site 1401659007006 NAD(P) binding site [chemical binding]; other site 1401659007007 trimer interface B [polypeptide binding]; other site 1401659007008 trimer interface A [polypeptide binding]; other site 1401659007009 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1401659007010 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1401659007011 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1401659007012 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1401659007013 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1401659007014 dihydromonapterin reductase; Provisional; Region: PRK06483 1401659007015 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1401659007016 NAD(P) binding site [chemical binding]; other site 1401659007017 active site 1401659007018 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 1401659007019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1401659007020 active site 1401659007021 phosphorylation site [posttranslational modification] 1401659007022 intermolecular recognition site; other site 1401659007023 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1401659007024 DNA binding site [nucleotide binding] 1401659007025 short chain dehydrogenase; Provisional; Region: PRK06500 1401659007026 classical (c) SDRs; Region: SDR_c; cd05233 1401659007027 NAD(P) binding site [chemical binding]; other site 1401659007028 active site 1401659007029 LysR family transcriptional regulator; Provisional; Region: PRK14997 1401659007030 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659007031 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 1401659007032 putative effector binding pocket; other site 1401659007033 putative dimerization interface [polypeptide binding]; other site 1401659007034 sensor protein RstB; Provisional; Region: PRK10604 1401659007035 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1401659007036 dimerization interface [polypeptide binding]; other site 1401659007037 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1401659007038 dimer interface [polypeptide binding]; other site 1401659007039 phosphorylation site [posttranslational modification] 1401659007040 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1401659007041 ATP binding site [chemical binding]; other site 1401659007042 Mg2+ binding site [ion binding]; other site 1401659007043 G-X-G motif; other site 1401659007044 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 1401659007045 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1401659007046 Class II fumarases; Region: Fumarase_classII; cd01362 1401659007047 active site 1401659007048 tetramer interface [polypeptide binding]; other site 1401659007049 fumarate hydratase; Provisional; Region: PRK15389 1401659007050 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 1401659007051 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1401659007052 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1401659007053 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1401659007054 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1401659007055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 1401659007056 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 1401659007057 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 1401659007058 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1401659007059 DNA binding site [nucleotide binding] 1401659007060 domain linker motif; other site 1401659007061 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1401659007062 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 1401659007063 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1401659007064 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1401659007065 active site turn [active] 1401659007066 phosphorylation site [posttranslational modification] 1401659007067 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1401659007068 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1401659007069 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659007070 homodimer interface [polypeptide binding]; other site 1401659007071 catalytic residue [active] 1401659007072 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1401659007073 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1401659007074 active site 1401659007075 purine riboside binding site [chemical binding]; other site 1401659007076 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1401659007077 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1401659007078 putative oxidoreductase; Provisional; Region: PRK11579 1401659007079 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1401659007080 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1401659007081 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 1401659007082 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 1401659007083 electron transport complex protein RsxA; Provisional; Region: PRK05151 1401659007084 ferredoxin; Provisional; Region: PRK08764 1401659007085 Putative Fe-S cluster; Region: FeS; pfam04060 1401659007086 4Fe-4S binding domain; Region: Fer4; cl02805 1401659007087 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 1401659007088 SLBB domain; Region: SLBB; pfam10531 1401659007089 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1401659007090 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 1401659007091 electron transport complex protein RnfG; Validated; Region: PRK01908 1401659007092 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1401659007093 endonuclease III; Provisional; Region: PRK10702 1401659007094 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1401659007095 minor groove reading motif; other site 1401659007096 helix-hairpin-helix signature motif; other site 1401659007097 substrate binding pocket [chemical binding]; other site 1401659007098 active site 1401659007099 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1401659007100 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 1401659007101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659007102 putative substrate translocation pore; other site 1401659007103 POT family; Region: PTR2; pfam00854 1401659007104 glutathionine S-transferase; Provisional; Region: PRK10542 1401659007105 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1401659007106 C-terminal domain interface [polypeptide binding]; other site 1401659007107 GSH binding site (G-site) [chemical binding]; other site 1401659007108 dimer interface [polypeptide binding]; other site 1401659007109 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1401659007110 dimer interface [polypeptide binding]; other site 1401659007111 N-terminal domain interface [polypeptide binding]; other site 1401659007112 substrate binding pocket (H-site) [chemical binding]; other site 1401659007113 pyridoxamine kinase; Validated; Region: PRK05756 1401659007114 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1401659007115 dimer interface [polypeptide binding]; other site 1401659007116 pyridoxal binding site [chemical binding]; other site 1401659007117 ATP binding site [chemical binding]; other site 1401659007118 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1401659007119 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1401659007120 active site 1401659007121 HIGH motif; other site 1401659007122 dimer interface [polypeptide binding]; other site 1401659007123 KMSKS motif; other site 1401659007124 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1401659007125 RNA binding surface [nucleotide binding]; other site 1401659007126 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1401659007127 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1401659007128 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1401659007129 lysozyme inhibitor; Provisional; Region: PRK11372 1401659007130 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1401659007131 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1401659007132 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 1401659007133 transcriptional regulator SlyA; Provisional; Region: PRK03573 1401659007134 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1401659007135 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 1401659007136 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1401659007137 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1401659007138 HlyD family secretion protein; Region: HlyD_3; pfam13437 1401659007139 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1401659007140 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1401659007141 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1401659007142 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1401659007143 E-class dimer interface [polypeptide binding]; other site 1401659007144 P-class dimer interface [polypeptide binding]; other site 1401659007145 active site 1401659007146 Cu2+ binding site [ion binding]; other site 1401659007147 Zn2+ binding site [ion binding]; other site 1401659007148 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1401659007149 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1401659007150 active site 1401659007151 catalytic tetrad [active] 1401659007152 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 1401659007153 putative metal dependent hydrolase; Provisional; Region: PRK11598 1401659007154 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1401659007155 Sulfatase; Region: Sulfatase; pfam00884 1401659007156 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1401659007157 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1401659007158 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1401659007159 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1401659007160 FMN binding site [chemical binding]; other site 1401659007161 active site 1401659007162 substrate binding site [chemical binding]; other site 1401659007163 catalytic residue [active] 1401659007164 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1401659007165 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1401659007166 dimer interface [polypeptide binding]; other site 1401659007167 active site 1401659007168 glutathione binding site [chemical binding]; other site 1401659007169 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1401659007170 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 1401659007171 dimer interface [polypeptide binding]; other site 1401659007172 catalytic site [active] 1401659007173 putative active site [active] 1401659007174 putative substrate binding site [chemical binding]; other site 1401659007175 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1401659007176 putative GSH binding site [chemical binding]; other site 1401659007177 catalytic residues [active] 1401659007178 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1401659007179 NlpC/P60 family; Region: NLPC_P60; pfam00877 1401659007180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659007181 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1401659007182 putative substrate translocation pore; other site 1401659007183 hypothetical protein; Provisional; Region: PRK14756 1401659007184 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 1401659007185 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1401659007186 DNA binding site [nucleotide binding] 1401659007187 domain linker motif; other site 1401659007188 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1401659007189 dimerization interface [polypeptide binding]; other site 1401659007190 ligand binding site [chemical binding]; other site 1401659007191 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1401659007192 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659007193 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1401659007194 dimerization interface [polypeptide binding]; other site 1401659007195 putative transporter; Provisional; Region: PRK11043 1401659007196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659007197 putative substrate translocation pore; other site 1401659007198 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 1401659007199 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1401659007200 S-adenosylmethionine binding site [chemical binding]; other site 1401659007201 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1401659007202 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1401659007203 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1401659007204 beta-galactosidase; Region: BGL; TIGR03356 1401659007205 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1401659007206 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1401659007207 DNA binding site [nucleotide binding] 1401659007208 domain linker motif; other site 1401659007209 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1401659007210 dimerization interface [polypeptide binding]; other site 1401659007211 ligand binding site [chemical binding]; other site 1401659007212 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 1401659007213 Lumazine binding domain; Region: Lum_binding; pfam00677 1401659007214 Lumazine binding domain; Region: Lum_binding; pfam00677 1401659007215 multidrug efflux protein; Reviewed; Region: PRK01766 1401659007216 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1401659007217 cation binding site [ion binding]; other site 1401659007218 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 1401659007219 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 1401659007220 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 1401659007221 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 1401659007222 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1401659007223 Protein of unknown function (DUF770); Region: DUF770; pfam05591 1401659007224 AAA domain; Region: AAA_28; pfam13521 1401659007225 Predicted ATPase [General function prediction only]; Region: COG3911 1401659007226 Fic/DOC family; Region: Fic; pfam02661 1401659007227 choline transport protein BetT; Provisional; Region: PRK09928 1401659007228 transcriptional regulator BetI; Validated; Region: PRK00767 1401659007229 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1401659007230 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1401659007231 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 1401659007232 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 1401659007233 tetrameric interface [polypeptide binding]; other site 1401659007234 NAD binding site [chemical binding]; other site 1401659007235 catalytic residues [active] 1401659007236 choline dehydrogenase; Validated; Region: PRK02106 1401659007237 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1401659007238 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1401659007239 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659007240 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1401659007241 dimerization interface [polypeptide binding]; other site 1401659007242 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1401659007243 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1401659007244 Sigma-S stabilisation anti-adaptor protein; Region: Anti-adapt_IraP; pfam10796 1401659007245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659007246 putative substrate translocation pore; other site 1401659007247 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 1401659007248 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659007249 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 1401659007250 putative substrate binding pocket [chemical binding]; other site 1401659007251 putative dimerization interface [polypeptide binding]; other site 1401659007252 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1401659007253 molybdopterin cofactor binding site; other site 1401659007254 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 1401659007255 molybdopterin cofactor binding site; other site 1401659007256 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1401659007257 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1401659007258 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 1401659007259 Acylphosphatase; Region: Acylphosphatase; pfam00708 1401659007260 HypF finger; Region: zf-HYPF; pfam07503 1401659007261 HypF finger; Region: zf-HYPF; pfam07503 1401659007262 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1401659007263 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1401659007264 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1401659007265 [4Fe-4S] binding site [ion binding]; other site 1401659007266 molybdopterin cofactor binding site; other site 1401659007267 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 1401659007268 molybdopterin cofactor binding site; other site 1401659007269 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1401659007270 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1401659007271 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 1401659007272 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 1401659007273 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 1401659007274 nickel binding site [ion binding]; other site 1401659007275 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 1401659007276 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1401659007277 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 1401659007278 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1401659007279 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 1401659007280 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1401659007281 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1401659007282 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1401659007283 NADH dehydrogenase; Region: NADHdh; cl00469 1401659007284 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 1401659007285 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1401659007286 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1401659007287 Transcriptional repressor of hyc and hyp operons; Region: HycA_repressor; cl08095 1401659007288 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 1401659007289 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 1401659007290 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 1401659007291 hydrogenase assembly chaperone; Provisional; Region: PRK10409 1401659007292 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 1401659007293 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 1401659007294 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 1401659007295 dimerization interface [polypeptide binding]; other site 1401659007296 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 1401659007297 ATP binding site [chemical binding]; other site 1401659007298 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 1401659007299 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1401659007300 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1401659007301 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1401659007302 Walker A motif; other site 1401659007303 ATP binding site [chemical binding]; other site 1401659007304 Walker B motif; other site 1401659007305 arginine finger; other site 1401659007306 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1401659007307 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1401659007308 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1401659007309 Peptidase C26; Region: Peptidase_C26; pfam07722 1401659007310 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1401659007311 catalytic triad [active] 1401659007312 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1401659007313 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1401659007314 non-specific DNA binding site [nucleotide binding]; other site 1401659007315 salt bridge; other site 1401659007316 sequence-specific DNA binding site [nucleotide binding]; other site 1401659007317 Cupin domain; Region: Cupin_2; pfam07883 1401659007318 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 1401659007319 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1401659007320 NAD(P) binding site [chemical binding]; other site 1401659007321 catalytic residues [active] 1401659007322 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1401659007323 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1401659007324 hypothetical protein; Provisional; Region: PRK09945 1401659007325 hypothetical protein; Provisional; Region: PRK09945 1401659007326 hypothetical protein; Provisional; Region: PRK09945 1401659007327 hypothetical protein; Provisional; Region: PRK09945 1401659007328 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1401659007329 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1401659007330 Autotransporter beta-domain; Region: Autotransporter; smart00869 1401659007331 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1401659007332 pyruvate kinase; Provisional; Region: PRK09206 1401659007333 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1401659007334 domain interfaces; other site 1401659007335 active site 1401659007336 murein lipoprotein; Provisional; Region: PRK15396 1401659007337 L,D-transpeptidase; Provisional; Region: PRK10190 1401659007338 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1401659007339 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1401659007340 cysteine desufuration protein SufE; Provisional; Region: PRK09296 1401659007341 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1401659007342 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1401659007343 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1401659007344 catalytic residue [active] 1401659007345 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 1401659007346 FeS assembly protein SufD; Region: sufD; TIGR01981 1401659007347 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 1401659007348 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1401659007349 Walker A/P-loop; other site 1401659007350 ATP binding site [chemical binding]; other site 1401659007351 Q-loop/lid; other site 1401659007352 ABC transporter signature motif; other site 1401659007353 Walker B; other site 1401659007354 D-loop; other site 1401659007355 H-loop/switch region; other site 1401659007356 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1401659007357 putative ABC transporter; Region: ycf24; CHL00085 1401659007358 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 1401659007359 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 1401659007360 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1401659007361 catalytic core [active] 1401659007362 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1401659007363 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1401659007364 CoenzymeA binding site [chemical binding]; other site 1401659007365 subunit interaction site [polypeptide binding]; other site 1401659007366 PHB binding site; other site 1401659007367 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1401659007368 FAD binding domain; Region: FAD_binding_4; pfam01565 1401659007369 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1401659007370 putative inner membrane protein; Provisional; Region: PRK10983 1401659007371 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1401659007372 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1401659007373 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1401659007374 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1401659007375 putative symporter YagG; Provisional; Region: PRK09669 1401659007376 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1401659007377 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1401659007378 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1401659007379 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1401659007380 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1401659007381 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1401659007382 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 1401659007383 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1401659007384 hypothetical protein; Validated; Region: PRK00029 1401659007385 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1401659007386 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 1401659007387 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1401659007388 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1401659007389 DNA binding site [nucleotide binding] 1401659007390 domain linker motif; other site 1401659007391 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1401659007392 dimerization interface (closed form) [polypeptide binding]; other site 1401659007393 ligand binding site [chemical binding]; other site 1401659007394 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1401659007395 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1401659007396 NAD binding site [chemical binding]; other site 1401659007397 sugar binding site [chemical binding]; other site 1401659007398 divalent metal binding site [ion binding]; other site 1401659007399 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1401659007400 dimer interface [polypeptide binding]; other site 1401659007401 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1401659007402 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1401659007403 NlpC/P60 family; Region: NLPC_P60; pfam00877 1401659007404 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 1401659007405 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1401659007406 Walker A/P-loop; other site 1401659007407 ATP binding site [chemical binding]; other site 1401659007408 Q-loop/lid; other site 1401659007409 ABC transporter signature motif; other site 1401659007410 Walker B; other site 1401659007411 D-loop; other site 1401659007412 H-loop/switch region; other site 1401659007413 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1401659007414 catalytic residues [active] 1401659007415 dimer interface [polypeptide binding]; other site 1401659007416 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1401659007417 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1401659007418 ABC-ATPase subunit interface; other site 1401659007419 dimer interface [polypeptide binding]; other site 1401659007420 putative PBP binding regions; other site 1401659007421 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1401659007422 IHF dimer interface [polypeptide binding]; other site 1401659007423 IHF - DNA interface [nucleotide binding]; other site 1401659007424 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1401659007425 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1401659007426 putative tRNA-binding site [nucleotide binding]; other site 1401659007427 B3/4 domain; Region: B3_4; pfam03483 1401659007428 tRNA synthetase B5 domain; Region: B5; smart00874 1401659007429 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1401659007430 dimer interface [polypeptide binding]; other site 1401659007431 motif 1; other site 1401659007432 motif 3; other site 1401659007433 motif 2; other site 1401659007434 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1401659007435 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1401659007436 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1401659007437 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1401659007438 dimer interface [polypeptide binding]; other site 1401659007439 motif 1; other site 1401659007440 active site 1401659007441 motif 2; other site 1401659007442 motif 3; other site 1401659007443 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1401659007444 23S rRNA binding site [nucleotide binding]; other site 1401659007445 L21 binding site [polypeptide binding]; other site 1401659007446 L13 binding site [polypeptide binding]; other site 1401659007447 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1401659007448 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1401659007449 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1401659007450 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1401659007451 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1401659007452 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1401659007453 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1401659007454 active site 1401659007455 dimer interface [polypeptide binding]; other site 1401659007456 motif 1; other site 1401659007457 motif 2; other site 1401659007458 motif 3; other site 1401659007459 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1401659007460 anticodon binding site; other site 1401659007461 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1401659007462 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1401659007463 Coenzyme A binding pocket [chemical binding]; other site 1401659007464 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1401659007465 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659007466 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1401659007467 dimerization interface [polypeptide binding]; other site 1401659007468 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1401659007469 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1401659007470 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1401659007471 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1401659007472 Coenzyme A binding pocket [chemical binding]; other site 1401659007473 ecotin; Provisional; Region: PRK03719 1401659007474 secondary substrate binding site; other site 1401659007475 primary substrate binding site; other site 1401659007476 inhibition loop; other site 1401659007477 dimerization interface [polypeptide binding]; other site 1401659007478 proline/glycine betaine transporter; Provisional; Region: PRK10642 1401659007479 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659007480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659007481 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 1401659007482 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 1401659007483 6-phosphofructokinase 2; Provisional; Region: PRK10294 1401659007484 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1401659007485 putative substrate binding site [chemical binding]; other site 1401659007486 putative ATP binding site [chemical binding]; other site 1401659007487 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 1401659007488 Fructosamine kinase; Region: Fructosamin_kin; pfam03881 1401659007489 Phosphotransferase enzyme family; Region: APH; pfam01636 1401659007490 YniB-like protein; Region: YniB; pfam14002 1401659007491 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 1401659007492 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1401659007493 motif II; other site 1401659007494 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 1401659007495 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1401659007496 NADP binding site [chemical binding]; other site 1401659007497 homodimer interface [polypeptide binding]; other site 1401659007498 active site 1401659007499 inner membrane protein; Provisional; Region: PRK11648 1401659007500 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1401659007501 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1401659007502 cell division modulator; Provisional; Region: PRK10113 1401659007503 hydroperoxidase II; Provisional; Region: katE; PRK11249 1401659007504 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1401659007505 tetramer interface [polypeptide binding]; other site 1401659007506 heme binding pocket [chemical binding]; other site 1401659007507 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1401659007508 domain interactions; other site 1401659007509 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 1401659007510 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1401659007511 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1401659007512 homodimer interface [polypeptide binding]; other site 1401659007513 NAD binding pocket [chemical binding]; other site 1401659007514 ATP binding pocket [chemical binding]; other site 1401659007515 Mg binding site [ion binding]; other site 1401659007516 active-site loop [active] 1401659007517 aromatic amino acid exporter; Provisional; Region: PRK11689 1401659007518 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 1401659007519 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1401659007520 GIY-YIG motif/motif A; other site 1401659007521 active site 1401659007522 catalytic site [active] 1401659007523 putative DNA binding site [nucleotide binding]; other site 1401659007524 metal binding site [ion binding]; metal-binding site 1401659007525 HutD; Region: HutD; cl01532 1401659007526 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1401659007527 dimer interface [polypeptide binding]; other site 1401659007528 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 1401659007529 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1401659007530 putative active site [active] 1401659007531 Zn binding site [ion binding]; other site 1401659007532 succinylarginine dihydrolase; Provisional; Region: PRK13281 1401659007533 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 1401659007534 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 1401659007535 NAD(P) binding site [chemical binding]; other site 1401659007536 catalytic residues [active] 1401659007537 arginine succinyltransferase; Provisional; Region: PRK10456 1401659007538 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1401659007539 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 1401659007540 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1401659007541 inhibitor-cofactor binding pocket; inhibition site 1401659007542 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659007543 catalytic residue [active] 1401659007544 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1401659007545 putative catalytic site [active] 1401659007546 putative phosphate binding site [ion binding]; other site 1401659007547 active site 1401659007548 metal binding site A [ion binding]; metal-binding site 1401659007549 DNA binding site [nucleotide binding] 1401659007550 putative AP binding site [nucleotide binding]; other site 1401659007551 putative metal binding site B [ion binding]; other site 1401659007552 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1401659007553 active site 1401659007554 8-oxo-dGMP binding site [chemical binding]; other site 1401659007555 nudix motif; other site 1401659007556 metal binding site [ion binding]; metal-binding site 1401659007557 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 1401659007558 DNA topoisomerase III; Provisional; Region: PRK07726 1401659007559 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1401659007560 active site 1401659007561 putative interdomain interaction site [polypeptide binding]; other site 1401659007562 putative metal-binding site [ion binding]; other site 1401659007563 putative nucleotide binding site [chemical binding]; other site 1401659007564 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1401659007565 domain I; other site 1401659007566 DNA binding groove [nucleotide binding] 1401659007567 phosphate binding site [ion binding]; other site 1401659007568 domain II; other site 1401659007569 domain III; other site 1401659007570 nucleotide binding site [chemical binding]; other site 1401659007571 catalytic site [active] 1401659007572 domain IV; other site 1401659007573 selenophosphate synthetase; Provisional; Region: PRK00943 1401659007574 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1401659007575 dimerization interface [polypeptide binding]; other site 1401659007576 putative ATP binding site [chemical binding]; other site 1401659007577 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1401659007578 putative FMN binding site [chemical binding]; other site 1401659007579 protease 4; Provisional; Region: PRK10949 1401659007580 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1401659007581 tandem repeat interface [polypeptide binding]; other site 1401659007582 oligomer interface [polypeptide binding]; other site 1401659007583 active site residues [active] 1401659007584 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 1401659007585 tandem repeat interface [polypeptide binding]; other site 1401659007586 oligomer interface [polypeptide binding]; other site 1401659007587 active site residues [active] 1401659007588 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1401659007589 active site 1401659007590 homodimer interface [polypeptide binding]; other site 1401659007591 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1401659007592 Isochorismatase family; Region: Isochorismatase; pfam00857 1401659007593 catalytic triad [active] 1401659007594 metal binding site [ion binding]; metal-binding site 1401659007595 conserved cis-peptide bond; other site 1401659007596 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 1401659007597 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1401659007598 SelR domain; Region: SelR; pfam01641 1401659007599 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 1401659007600 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1401659007601 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1401659007602 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1401659007603 active site 1401659007604 phosphate binding residues; other site 1401659007605 catalytic residues [active] 1401659007606 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1401659007607 PrkA family serine protein kinase; Provisional; Region: PRK15455 1401659007608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1401659007609 Walker A motif; other site 1401659007610 ATP binding site [chemical binding]; other site 1401659007611 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1401659007612 hypothetical protein; Provisional; Region: PRK05325 1401659007613 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1401659007614 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1401659007615 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1401659007616 General stress protein [General function prediction only]; Region: GsiB; COG3729 1401659007617 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 1401659007618 putative deacylase active site [active] 1401659007619 Predicted membrane protein [Function unknown]; Region: COG2707 1401659007620 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1401659007621 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659007622 hypothetical protein; Validated; Region: PRK06186 1401659007623 conserved cys residue [active] 1401659007624 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1401659007625 Protein of unknown function (DUF535); Region: DUF535; pfam04393 1401659007626 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1401659007627 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1401659007628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1401659007629 active site 1401659007630 phosphorylation site [posttranslational modification] 1401659007631 intermolecular recognition site; other site 1401659007632 dimerization interface [polypeptide binding]; other site 1401659007633 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1401659007634 DNA-binding site [nucleotide binding]; DNA binding site 1401659007635 RNA-binding motif; other site 1401659007636 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 1401659007637 Tar ligand binding domain homologue; Region: TarH; pfam02203 1401659007638 dimer interface [polypeptide binding]; other site 1401659007639 ligand binding site [chemical binding]; other site 1401659007640 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1401659007641 dimerization interface [polypeptide binding]; other site 1401659007642 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1401659007643 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1401659007644 dimer interface [polypeptide binding]; other site 1401659007645 putative CheW interface [polypeptide binding]; other site 1401659007646 Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783 1401659007647 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1401659007648 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1401659007649 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1401659007650 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659007651 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1401659007652 putative effector binding pocket; other site 1401659007653 dimerization interface [polypeptide binding]; other site 1401659007654 MltA-interacting protein MipA; Region: MipA; cl01504 1401659007655 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1401659007656 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1401659007657 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1401659007658 dimer interface [polypeptide binding]; other site 1401659007659 phosphorylation site [posttranslational modification] 1401659007660 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1401659007661 ATP binding site [chemical binding]; other site 1401659007662 Mg2+ binding site [ion binding]; other site 1401659007663 G-X-G motif; other site 1401659007664 isocitrate dehydrogenase; Validated; Region: PRK07362 1401659007665 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1401659007666 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 1401659007667 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 1401659007668 probable active site [active] 1401659007669 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 1401659007670 nudix motif; other site 1401659007671 Cache domain; Region: Cache_1; pfam02743 1401659007672 HAMP domain; Region: HAMP; pfam00672 1401659007673 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1401659007674 dimer interface [polypeptide binding]; other site 1401659007675 putative CheW interface [polypeptide binding]; other site 1401659007676 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1401659007677 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 1401659007678 putative lysogenization regulator; Reviewed; Region: PRK00218 1401659007679 adenylosuccinate lyase; Provisional; Region: PRK09285 1401659007680 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1401659007681 tetramer interface [polypeptide binding]; other site 1401659007682 active site 1401659007683 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 1401659007684 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1401659007685 active site 1401659007686 phosphorylation site [posttranslational modification] 1401659007687 intermolecular recognition site; other site 1401659007688 dimerization interface [polypeptide binding]; other site 1401659007689 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1401659007690 DNA binding site [nucleotide binding] 1401659007691 sensor protein PhoQ; Provisional; Region: PRK10815 1401659007692 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 1401659007693 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1401659007694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1401659007695 ATP binding site [chemical binding]; other site 1401659007696 Mg2+ binding site [ion binding]; other site 1401659007697 G-X-G motif; other site 1401659007698 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1401659007699 Cupin-like domain; Region: Cupin_8; pfam13621 1401659007700 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 1401659007701 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1401659007702 metal binding site [ion binding]; metal-binding site 1401659007703 dimer interface [polypeptide binding]; other site 1401659007704 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 1401659007705 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1401659007706 Walker A/P-loop; other site 1401659007707 ATP binding site [chemical binding]; other site 1401659007708 Q-loop/lid; other site 1401659007709 ABC transporter signature motif; other site 1401659007710 Walker B; other site 1401659007711 D-loop; other site 1401659007712 H-loop/switch region; other site 1401659007713 TOBE domain; Region: TOBE_2; pfam08402 1401659007714 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1401659007715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659007716 dimer interface [polypeptide binding]; other site 1401659007717 conserved gate region; other site 1401659007718 putative PBP binding loops; other site 1401659007719 ABC-ATPase subunit interface; other site 1401659007720 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1401659007721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659007722 dimer interface [polypeptide binding]; other site 1401659007723 conserved gate region; other site 1401659007724 putative PBP binding loops; other site 1401659007725 ABC-ATPase subunit interface; other site 1401659007726 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 1401659007727 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1401659007728 NAD-dependent deacetylase; Provisional; Region: PRK00481 1401659007729 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1401659007730 NAD+ binding site [chemical binding]; other site 1401659007731 substrate binding site [chemical binding]; other site 1401659007732 Zn binding site [ion binding]; other site 1401659007733 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1401659007734 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1401659007735 nucleotide binding site [chemical binding]; other site 1401659007736 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 1401659007737 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1401659007738 FtsX-like permease family; Region: FtsX; pfam02687 1401659007739 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 1401659007740 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1401659007741 Walker A/P-loop; other site 1401659007742 ATP binding site [chemical binding]; other site 1401659007743 Q-loop/lid; other site 1401659007744 ABC transporter signature motif; other site 1401659007745 Walker B; other site 1401659007746 D-loop; other site 1401659007747 H-loop/switch region; other site 1401659007748 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 1401659007749 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1401659007750 FtsX-like permease family; Region: FtsX; pfam02687 1401659007751 transcription-repair coupling factor; Provisional; Region: PRK10689 1401659007752 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1401659007753 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1401659007754 ATP binding site [chemical binding]; other site 1401659007755 putative Mg++ binding site [ion binding]; other site 1401659007756 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1401659007757 nucleotide binding region [chemical binding]; other site 1401659007758 ATP-binding site [chemical binding]; other site 1401659007759 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1401659007760 L,D-transpeptidase; Provisional; Region: PRK10190 1401659007761 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1401659007762 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1401659007763 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1401659007764 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1401659007765 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1401659007766 hypothetical protein; Provisional; Region: PRK11280 1401659007767 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1401659007768 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1401659007769 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1401659007770 hypothetical protein; Provisional; Region: PRK04940 1401659007771 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1401659007772 beta-hexosaminidase; Provisional; Region: PRK05337 1401659007773 thiamine kinase; Region: ycfN_thiK; TIGR02721 1401659007774 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1401659007775 active site 1401659007776 substrate binding site [chemical binding]; other site 1401659007777 ATP binding site [chemical binding]; other site 1401659007778 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 1401659007779 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 1401659007780 putative dimer interface [polypeptide binding]; other site 1401659007781 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1401659007782 nucleotide binding site/active site [active] 1401659007783 HIT family signature motif; other site 1401659007784 catalytic residue [active] 1401659007785 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 1401659007786 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1401659007787 N-terminal plug; other site 1401659007788 ligand-binding site [chemical binding]; other site 1401659007789 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 1401659007790 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1401659007791 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1401659007792 active site turn [active] 1401659007793 phosphorylation site [posttranslational modification] 1401659007794 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1401659007795 active site 1401659007796 DNA polymerase III subunit delta'; Validated; Region: PRK07993 1401659007797 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 1401659007798 thymidylate kinase; Validated; Region: tmk; PRK00698 1401659007799 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1401659007800 TMP-binding site; other site 1401659007801 ATP-binding site [chemical binding]; other site 1401659007802 conserved hypothetical protein, YceG family; Region: TIGR00247 1401659007803 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1401659007804 dimerization interface [polypeptide binding]; other site 1401659007805 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1401659007806 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1401659007807 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659007808 catalytic residue [active] 1401659007809 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1401659007810 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1401659007811 dimer interface [polypeptide binding]; other site 1401659007812 active site 1401659007813 acyl carrier protein; Provisional; Region: acpP; PRK00982 1401659007814 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1401659007815 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1401659007816 NAD(P) binding site [chemical binding]; other site 1401659007817 homotetramer interface [polypeptide binding]; other site 1401659007818 homodimer interface [polypeptide binding]; other site 1401659007819 active site 1401659007820 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1401659007821 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1401659007822 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1401659007823 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1401659007824 dimer interface [polypeptide binding]; other site 1401659007825 active site 1401659007826 CoA binding pocket [chemical binding]; other site 1401659007827 putative phosphate acyltransferase; Provisional; Region: PRK05331 1401659007828 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1401659007829 hypothetical protein; Provisional; Region: PRK11193 1401659007830 Maf-like protein; Region: Maf; pfam02545 1401659007831 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1401659007832 active site 1401659007833 dimer interface [polypeptide binding]; other site 1401659007834 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 1401659007835 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1401659007836 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1401659007837 RNA binding surface [nucleotide binding]; other site 1401659007838 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1401659007839 active site 1401659007840 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1401659007841 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1401659007842 homodimer interface [polypeptide binding]; other site 1401659007843 oligonucleotide binding site [chemical binding]; other site 1401659007844 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 1401659007845 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1401659007846 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659007847 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1401659007848 putative effector binding pocket; other site 1401659007849 dimerization interface [polypeptide binding]; other site 1401659007850 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659007851 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1401659007852 putative substrate translocation pore; other site 1401659007853 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 1401659007854 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1401659007855 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 1401659007856 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1401659007857 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1401659007858 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 1401659007859 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 1401659007860 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1401659007861 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1401659007862 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1401659007863 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 1401659007864 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 1401659007865 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1401659007866 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1401659007867 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1401659007868 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 1401659007869 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1401659007870 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1401659007871 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1401659007872 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1401659007873 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1401659007874 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1401659007875 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 1401659007876 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1401659007877 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1401659007878 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1401659007879 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1401659007880 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1401659007881 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1401659007882 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1401659007883 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 1401659007884 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1401659007885 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 1401659007886 FlgN protein; Region: FlgN; cl09176 1401659007887 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1401659007888 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1401659007889 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1401659007890 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1401659007891 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1401659007892 hypothetical protein; Provisional; Region: PRK11239 1401659007893 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 1401659007894 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 1401659007895 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1401659007896 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1401659007897 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659007898 putative substrate translocation pore; other site 1401659007899 glutaredoxin 2; Provisional; Region: PRK10387 1401659007900 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 1401659007901 C-terminal domain interface [polypeptide binding]; other site 1401659007902 GSH binding site (G-site) [chemical binding]; other site 1401659007903 catalytic residues [active] 1401659007904 putative dimer interface [polypeptide binding]; other site 1401659007905 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 1401659007906 N-terminal domain interface [polypeptide binding]; other site 1401659007907 lipoprotein; Provisional; Region: PRK10598 1401659007908 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1401659007909 active site 1401659007910 substrate binding pocket [chemical binding]; other site 1401659007911 dimer interface [polypeptide binding]; other site 1401659007912 DNA damage-inducible protein I; Provisional; Region: PRK10597 1401659007913 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 1401659007914 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1401659007915 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1401659007916 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1401659007917 hypothetical protein; Provisional; Region: PRK03757 1401659007918 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1401659007919 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1401659007920 active site residue [active] 1401659007921 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1401659007922 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1401659007923 putative acyl-acceptor binding pocket; other site 1401659007924 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 1401659007925 Putative phage tail protein; Region: Phage-tail_3; pfam13550 1401659007926 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1401659007927 Interdomain contacts; other site 1401659007928 Cytokine receptor motif; other site 1401659007929 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 1401659007930 Fibronectin type III protein; Region: DUF3672; pfam12421 1401659007931 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 1401659007932 Phage capsid family; Region: Phage_capsid; pfam05065 1401659007933 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 1401659007934 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 1401659007935 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 1401659007936 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1401659007937 catalytic residues [active] 1401659007938 catalytic nucleophile [active] 1401659007939 Recombinase; Region: Recombinase; pfam07508 1401659007940 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1401659007941 secY/secA suppressor protein; Provisional; Region: PRK11467 1401659007942 lipoprotein; Provisional; Region: PRK10175 1401659007943 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1401659007944 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 1401659007945 Ligand binding site; other site 1401659007946 DXD motif; other site 1401659007947 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 1401659007948 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 1401659007949 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1401659007950 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1401659007951 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 1401659007952 putative active site [active] 1401659007953 catalytic site [active] 1401659007954 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 1401659007955 PLD-like domain; Region: PLDc_2; pfam13091 1401659007956 putative active site [active] 1401659007957 catalytic site [active] 1401659007958 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1401659007959 putative ADP-ribose binding site [chemical binding]; other site 1401659007960 putative active site [active] 1401659007961 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1401659007962 Thin aggregative fimbriae synthesis protein; Region: Tafi-CsgC; cl11667 1401659007963 major curlin subunit; Provisional; Region: csgA; PRK10051 1401659007964 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 1401659007965 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1401659007966 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 1401659007967 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1401659007968 DNA binding residues [nucleotide binding] 1401659007969 dimerization interface [polypeptide binding]; other site 1401659007970 curli assembly protein CsgE; Provisional; Region: PRK10386 1401659007971 curli assembly protein CsgF; Provisional; Region: PRK10050 1401659007972 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 1401659007973 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 1401659007974 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 1401659007975 putative hydrolase; Validated; Region: PRK09248 1401659007976 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 1401659007977 active site 1401659007978 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 1401659007979 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 1401659007980 putative ligand binding site [chemical binding]; other site 1401659007981 NAD binding site [chemical binding]; other site 1401659007982 dimerization interface [polypeptide binding]; other site 1401659007983 catalytic site [active] 1401659007984 Fimbrial protein; Region: Fimbrial; cl01416 1401659007985 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1401659007986 PapC N-terminal domain; Region: PapC_N; pfam13954 1401659007987 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1401659007988 PapC C-terminal domain; Region: PapC_C; pfam13953 1401659007989 fimbrial chaperone protein StiB; Provisional; Region: PRK15299 1401659007990 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1401659007991 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1401659007992 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1401659007993 putative oxidoreductase; Provisional; Region: PRK09939 1401659007994 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1401659007995 putative molybdopterin cofactor binding site [chemical binding]; other site 1401659007996 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1401659007997 putative molybdopterin cofactor binding site; other site 1401659007998 hypothetical protein; Provisional; Region: PRK10536 1401659007999 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1401659008000 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1401659008001 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1401659008002 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 1401659008003 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1401659008004 Imelysin; Region: Peptidase_M75; pfam09375 1401659008005 FTR1 family protein; Region: TIGR00145 1401659008006 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1401659008007 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1401659008008 Nucleoside recognition; Region: Gate; pfam07670 1401659008009 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1401659008010 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 1401659008011 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1401659008012 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1401659008013 Na binding site [ion binding]; other site 1401659008014 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 1401659008015 Predicted transcriptional regulator [Transcription]; Region: COG3905 1401659008016 Proline dehydrogenase; Region: Pro_dh; pfam01619 1401659008017 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1401659008018 Glutamate binding site [chemical binding]; other site 1401659008019 NAD binding site [chemical binding]; other site 1401659008020 catalytic residues [active] 1401659008021 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 1401659008022 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1401659008023 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1401659008024 pyrimidine utilization protein A; Region: RutA; TIGR03612 1401659008025 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1401659008026 active site 1401659008027 dimer interface [polypeptide binding]; other site 1401659008028 non-prolyl cis peptide bond; other site 1401659008029 insertion regions; other site 1401659008030 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1401659008031 Isochorismatase family; Region: Isochorismatase; pfam00857 1401659008032 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1401659008033 catalytic triad [active] 1401659008034 conserved cis-peptide bond; other site 1401659008035 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1401659008036 homotrimer interaction site [polypeptide binding]; other site 1401659008037 putative active site [active] 1401659008038 pyrimidine utilization protein D; Region: RutD; TIGR03611 1401659008039 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 1401659008040 putative FMN binding site [chemical binding]; other site 1401659008041 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 1401659008042 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1401659008043 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 1401659008044 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1401659008045 hypothetical protein; Provisional; Region: PRK10174 1401659008046 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1401659008047 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1401659008048 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659008049 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1401659008050 dimerization interface [polypeptide binding]; other site 1401659008051 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 1401659008052 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1401659008053 ImpA domain protein; Region: DUF3702; pfam12486 1401659008054 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 1401659008055 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 1401659008056 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1401659008057 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 1401659008058 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1401659008059 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1401659008060 peptide binding site [polypeptide binding]; other site 1401659008061 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1401659008062 YccA-like proteins; Region: YccA_like; cd10433 1401659008063 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1401659008064 sulfur transfer protein TusE; Provisional; Region: PRK11508 1401659008065 acylphosphatase; Provisional; Region: PRK14426 1401659008066 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 1401659008067 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 1401659008068 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1401659008069 putative RNA binding site [nucleotide binding]; other site 1401659008070 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1401659008071 S-adenosylmethionine binding site [chemical binding]; other site 1401659008072 heat shock protein HspQ; Provisional; Region: PRK14129 1401659008073 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1401659008074 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1401659008075 active site 1401659008076 dimer interfaces [polypeptide binding]; other site 1401659008077 catalytic residues [active] 1401659008078 DNA helicase IV; Provisional; Region: helD; PRK11054 1401659008079 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 1401659008080 Part of AAA domain; Region: AAA_19; pfam13245 1401659008081 Family description; Region: UvrD_C_2; pfam13538 1401659008082 Predicted membrane protein [Function unknown]; Region: COG3304 1401659008083 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1401659008084 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1401659008085 TIGR01666 family membrane protein; Region: YCCS 1401659008086 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1401659008087 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1401659008088 TfoX N-terminal domain; Region: TfoX_N; pfam04993 1401659008089 TfoX C-terminal domain; Region: TfoX_C; pfam04994 1401659008090 SOS cell division inhibitor; Provisional; Region: PRK10595 1401659008091 outer membrane protein A; Reviewed; Region: PRK10808 1401659008092 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 1401659008093 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1401659008094 ligand binding site [chemical binding]; other site 1401659008095 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 1401659008096 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 1401659008097 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1401659008098 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1401659008099 active site 1 [active] 1401659008100 dimer interface [polypeptide binding]; other site 1401659008101 active site 2 [active] 1401659008102 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 1401659008103 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1401659008104 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1401659008105 paraquat-inducible protein B; Provisional; Region: PRK10807 1401659008106 mce related protein; Region: MCE; pfam02470 1401659008107 mce related protein; Region: MCE; pfam02470 1401659008108 mce related protein; Region: MCE; pfam02470 1401659008109 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 1401659008110 Paraquat-inducible protein A; Region: PqiA; pfam04403 1401659008111 Paraquat-inducible protein A; Region: PqiA; pfam04403 1401659008112 ABC transporter ATPase component; Reviewed; Region: PRK11147 1401659008113 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1401659008114 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1401659008115 Walker A/P-loop; other site 1401659008116 ATP binding site [chemical binding]; other site 1401659008117 Q-loop/lid; other site 1401659008118 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1401659008119 ABC transporter signature motif; other site 1401659008120 Walker B; other site 1401659008121 D-loop; other site 1401659008122 ABC transporter; Region: ABC_tran_2; pfam12848 1401659008123 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1401659008124 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 1401659008125 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1401659008126 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 1401659008127 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1401659008128 S-adenosylmethionine binding site [chemical binding]; other site 1401659008129 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1401659008130 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1401659008131 MOSC domain; Region: MOSC; pfam03473 1401659008132 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1401659008133 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1401659008134 catalytic loop [active] 1401659008135 iron binding site [ion binding]; other site 1401659008136 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 1401659008137 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1401659008138 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1401659008139 active site 1401659008140 catalytic residues [active] 1401659008141 FMN binding site [chemical binding]; other site 1401659008142 quinone interaction residues [chemical binding]; other site 1401659008143 substrate binding site [chemical binding]; other site 1401659008144 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 1401659008145 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1401659008146 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1401659008147 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1401659008148 substrate binding pocket [chemical binding]; other site 1401659008149 membrane-bound complex binding site; other site 1401659008150 hinge residues; other site 1401659008151 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1401659008152 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1401659008153 active site 1401659008154 dimer interface [polypeptide binding]; other site 1401659008155 non-prolyl cis peptide bond; other site 1401659008156 insertion regions; other site 1401659008157 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1401659008158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659008159 dimer interface [polypeptide binding]; other site 1401659008160 conserved gate region; other site 1401659008161 putative PBP binding loops; other site 1401659008162 ABC-ATPase subunit interface; other site 1401659008163 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 1401659008164 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1401659008165 Walker A/P-loop; other site 1401659008166 ATP binding site [chemical binding]; other site 1401659008167 Q-loop/lid; other site 1401659008168 ABC transporter signature motif; other site 1401659008169 Walker B; other site 1401659008170 D-loop; other site 1401659008171 H-loop/switch region; other site 1401659008172 aminopeptidase N; Provisional; Region: pepN; PRK14015 1401659008173 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1401659008174 active site 1401659008175 Zn binding site [ion binding]; other site 1401659008176 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 1401659008177 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 1401659008178 active site 1401659008179 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1401659008180 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1401659008181 putative dimer interface [polypeptide binding]; other site 1401659008182 putative anticodon binding site; other site 1401659008183 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1401659008184 homodimer interface [polypeptide binding]; other site 1401659008185 motif 1; other site 1401659008186 motif 2; other site 1401659008187 active site 1401659008188 motif 3; other site 1401659008189 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1401659008190 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1401659008191 trimer interface [polypeptide binding]; other site 1401659008192 eyelet of channel; other site 1401659008193 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1401659008194 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1401659008195 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659008196 homodimer interface [polypeptide binding]; other site 1401659008197 catalytic residue [active] 1401659008198 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1401659008199 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 1401659008200 Peptidase M15; Region: Peptidase_M15_3; cl01194 1401659008201 murein L,D-transpeptidase; Provisional; Region: PRK10594 1401659008202 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1401659008203 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1401659008204 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1401659008205 cell division protein MukB; Provisional; Region: mukB; PRK04863 1401659008206 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1401659008207 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1401659008208 condesin subunit E; Provisional; Region: PRK05256 1401659008209 condesin subunit F; Provisional; Region: PRK05260 1401659008210 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1401659008211 S-adenosylmethionine binding site [chemical binding]; other site 1401659008212 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1401659008213 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1401659008214 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1401659008215 putative active site [active] 1401659008216 hypothetical protein; Provisional; Region: PRK10593 1401659008217 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 1401659008218 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1401659008219 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1401659008220 AsnC family; Region: AsnC_trans_reg; pfam01037 1401659008221 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1401659008222 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1401659008223 Ligand binding site; other site 1401659008224 oligomer interface; other site 1401659008225 Trm112p-like protein; Region: Trm112p; cl01066 1401659008226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1401659008227 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1401659008228 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1401659008229 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 1401659008230 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 1401659008231 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1401659008232 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1401659008233 Walker A/P-loop; other site 1401659008234 ATP binding site [chemical binding]; other site 1401659008235 Q-loop/lid; other site 1401659008236 ABC transporter signature motif; other site 1401659008237 Walker B; other site 1401659008238 D-loop; other site 1401659008239 H-loop/switch region; other site 1401659008240 ComEC family competence protein; Provisional; Region: PRK11539 1401659008241 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1401659008242 Competence protein; Region: Competence; pfam03772 1401659008243 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1401659008244 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1401659008245 IHF dimer interface [polypeptide binding]; other site 1401659008246 IHF - DNA interface [nucleotide binding]; other site 1401659008247 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1401659008248 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1401659008249 RNA binding site [nucleotide binding]; other site 1401659008250 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1401659008251 RNA binding site [nucleotide binding]; other site 1401659008252 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 1401659008253 RNA binding site [nucleotide binding]; other site 1401659008254 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 1401659008255 RNA binding site [nucleotide binding]; other site 1401659008256 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1401659008257 RNA binding site [nucleotide binding]; other site 1401659008258 cytidylate kinase; Provisional; Region: cmk; PRK00023 1401659008259 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1401659008260 CMP-binding site; other site 1401659008261 The sites determining sugar specificity; other site 1401659008262 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1401659008263 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1401659008264 hinge; other site 1401659008265 active site 1401659008266 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1401659008267 homodimer interface [polypeptide binding]; other site 1401659008268 substrate-cofactor binding pocket; other site 1401659008269 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659008270 catalytic residue [active] 1401659008271 Predicted membrane protein [Function unknown]; Region: COG2323 1401659008272 uncharacterized domain; Region: TIGR00702 1401659008273 YcaO-like family; Region: YcaO; pfam02624 1401659008274 formate transporter; Provisional; Region: PRK10805 1401659008275 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1401659008276 Pyruvate formate lyase 1; Region: PFL1; cd01678 1401659008277 coenzyme A binding site [chemical binding]; other site 1401659008278 active site 1401659008279 catalytic residues [active] 1401659008280 glycine loop; other site 1401659008281 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 1401659008282 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1401659008283 FeS/SAM binding site; other site 1401659008284 putative MFS family transporter protein; Provisional; Region: PRK03633 1401659008285 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659008286 putative substrate translocation pore; other site 1401659008287 seryl-tRNA synthetase; Provisional; Region: PRK05431 1401659008288 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1401659008289 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1401659008290 dimer interface [polypeptide binding]; other site 1401659008291 active site 1401659008292 motif 1; other site 1401659008293 motif 2; other site 1401659008294 motif 3; other site 1401659008295 recombination factor protein RarA; Reviewed; Region: PRK13342 1401659008296 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1401659008297 Walker A motif; other site 1401659008298 ATP binding site [chemical binding]; other site 1401659008299 Walker B motif; other site 1401659008300 arginine finger; other site 1401659008301 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1401659008302 periplasmic chaperone LolA; Region: lolA; TIGR00547 1401659008303 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1401659008304 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1401659008305 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1401659008306 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1401659008307 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1401659008308 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1401659008309 putative DNA binding site [nucleotide binding]; other site 1401659008310 putative Zn2+ binding site [ion binding]; other site 1401659008311 AsnC family; Region: AsnC_trans_reg; pfam01037 1401659008312 thioredoxin reductase; Provisional; Region: PRK10262 1401659008313 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1401659008314 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1401659008315 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 1401659008316 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1401659008317 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1401659008318 Walker A/P-loop; other site 1401659008319 ATP binding site [chemical binding]; other site 1401659008320 Q-loop/lid; other site 1401659008321 ABC transporter signature motif; other site 1401659008322 Walker B; other site 1401659008323 D-loop; other site 1401659008324 H-loop/switch region; other site 1401659008325 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 1401659008326 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 1401659008327 Walker A/P-loop; other site 1401659008328 ATP binding site [chemical binding]; other site 1401659008329 Q-loop/lid; other site 1401659008330 ABC transporter signature motif; other site 1401659008331 Walker B; other site 1401659008332 D-loop; other site 1401659008333 H-loop/switch region; other site 1401659008334 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1401659008335 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1401659008336 rRNA binding site [nucleotide binding]; other site 1401659008337 predicted 30S ribosome binding site; other site 1401659008338 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 1401659008339 Clp amino terminal domain; Region: Clp_N; pfam02861 1401659008340 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1401659008341 Walker A motif; other site 1401659008342 ATP binding site [chemical binding]; other site 1401659008343 Walker B motif; other site 1401659008344 arginine finger; other site 1401659008345 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1401659008346 Walker A motif; other site 1401659008347 ATP binding site [chemical binding]; other site 1401659008348 Walker B motif; other site 1401659008349 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1401659008350 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1401659008351 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1401659008352 DNA-binding site [nucleotide binding]; DNA binding site 1401659008353 RNA-binding motif; other site 1401659008354 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1401659008355 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1401659008356 Walker A/P-loop; other site 1401659008357 ATP binding site [chemical binding]; other site 1401659008358 Q-loop/lid; other site 1401659008359 ABC transporter signature motif; other site 1401659008360 Walker B; other site 1401659008361 D-loop; other site 1401659008362 H-loop/switch region; other site 1401659008363 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1401659008364 FtsX-like permease family; Region: FtsX; pfam02687 1401659008365 macrolide transporter subunit MacA; Provisional; Region: PRK11578 1401659008366 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1401659008367 HlyD family secretion protein; Region: HlyD_3; pfam13437 1401659008368 Protein of unknown function (DUF535); Region: DUF535; pfam04393 1401659008369 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1401659008370 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 1401659008371 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1401659008372 putative active site [active] 1401659008373 putative metal-binding site [ion binding]; other site 1401659008374 Predicted membrane protein [Function unknown]; Region: COG2431 1401659008375 hybrid cluster protein; Provisional; Region: PRK05290 1401659008376 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1401659008377 ACS interaction site; other site 1401659008378 CODH interaction site; other site 1401659008379 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 1401659008380 hybrid metal cluster; other site 1401659008381 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 1401659008382 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1401659008383 FAD binding pocket [chemical binding]; other site 1401659008384 FAD binding motif [chemical binding]; other site 1401659008385 phosphate binding motif [ion binding]; other site 1401659008386 beta-alpha-beta structure motif; other site 1401659008387 NAD binding pocket [chemical binding]; other site 1401659008388 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1401659008389 catalytic loop [active] 1401659008390 iron binding site [ion binding]; other site 1401659008391 pyruvate dehydrogenase; Provisional; Region: PRK09124 1401659008392 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1401659008393 PYR/PP interface [polypeptide binding]; other site 1401659008394 dimer interface [polypeptide binding]; other site 1401659008395 tetramer interface [polypeptide binding]; other site 1401659008396 TPP binding site [chemical binding]; other site 1401659008397 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1401659008398 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1401659008399 TPP-binding site [chemical binding]; other site 1401659008400 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1401659008401 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1401659008402 tetramer interface [polypeptide binding]; other site 1401659008403 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659008404 catalytic residue [active] 1401659008405 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1401659008406 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1401659008407 NAD(P) binding site [chemical binding]; other site 1401659008408 active site 1401659008409 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1401659008410 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1401659008411 amidase catalytic site [active] 1401659008412 Zn binding residues [ion binding]; other site 1401659008413 substrate binding site [chemical binding]; other site 1401659008414 hypothetical protein; Provisional; Region: PRK02877 1401659008415 putative lipoprotein; Provisional; Region: PRK10533 1401659008416 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 1401659008417 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1401659008418 Walker A/P-loop; other site 1401659008419 ATP binding site [chemical binding]; other site 1401659008420 Q-loop/lid; other site 1401659008421 ABC transporter signature motif; other site 1401659008422 Walker B; other site 1401659008423 D-loop; other site 1401659008424 H-loop/switch region; other site 1401659008425 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1401659008426 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1401659008427 substrate binding pocket [chemical binding]; other site 1401659008428 membrane-bound complex binding site; other site 1401659008429 hinge residues; other site 1401659008430 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1401659008431 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659008432 dimer interface [polypeptide binding]; other site 1401659008433 conserved gate region; other site 1401659008434 putative PBP binding loops; other site 1401659008435 ABC-ATPase subunit interface; other site 1401659008436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659008437 dimer interface [polypeptide binding]; other site 1401659008438 conserved gate region; other site 1401659008439 putative PBP binding loops; other site 1401659008440 ABC-ATPase subunit interface; other site 1401659008441 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1401659008442 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1401659008443 substrate binding pocket [chemical binding]; other site 1401659008444 membrane-bound complex binding site; other site 1401659008445 hinge residues; other site 1401659008446 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 1401659008447 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 1401659008448 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1401659008449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659008450 dimer interface [polypeptide binding]; other site 1401659008451 conserved gate region; other site 1401659008452 putative PBP binding loops; other site 1401659008453 ABC-ATPase subunit interface; other site 1401659008454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659008455 dimer interface [polypeptide binding]; other site 1401659008456 conserved gate region; other site 1401659008457 putative PBP binding loops; other site 1401659008458 ABC-ATPase subunit interface; other site 1401659008459 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 1401659008460 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1401659008461 Walker A/P-loop; other site 1401659008462 ATP binding site [chemical binding]; other site 1401659008463 Q-loop/lid; other site 1401659008464 ABC transporter signature motif; other site 1401659008465 Walker B; other site 1401659008466 D-loop; other site 1401659008467 H-loop/switch region; other site 1401659008468 TOBE domain; Region: TOBE_2; pfam08402 1401659008469 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1401659008470 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1401659008471 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1401659008472 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1401659008473 RimK-like ATP-grasp domain; Region: RimK; pfam08443 1401659008474 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1401659008475 dimer interface [polypeptide binding]; other site 1401659008476 FMN binding site [chemical binding]; other site 1401659008477 NADPH bind site [chemical binding]; other site 1401659008478 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 1401659008479 putative transporter; Provisional; Region: PRK04972 1401659008480 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1401659008481 TrkA-C domain; Region: TrkA_C; pfam02080 1401659008482 TrkA-C domain; Region: TrkA_C; pfam02080 1401659008483 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1401659008484 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1401659008485 glucosamine-6-phosphate deaminase-like protein; Validated; Region: PRK02122 1401659008486 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1401659008487 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1401659008488 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1401659008489 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1401659008490 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659008491 putative substrate translocation pore; other site 1401659008492 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1401659008493 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1401659008494 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1401659008495 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1401659008496 active site 1401659008497 motif I; other site 1401659008498 motif II; other site 1401659008499 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1401659008500 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 1401659008501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659008502 putative substrate translocation pore; other site 1401659008503 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 1401659008504 active site 1401659008505 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1401659008506 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1401659008507 active site 1401659008508 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 1401659008509 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1401659008510 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1401659008511 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 1401659008512 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1401659008513 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1401659008514 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1401659008515 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1401659008516 putative C-terminal domain interface [polypeptide binding]; other site 1401659008517 putative GSH binding site (G-site) [chemical binding]; other site 1401659008518 putative dimer interface [polypeptide binding]; other site 1401659008519 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1401659008520 putative N-terminal domain interface [polypeptide binding]; other site 1401659008521 putative dimer interface [polypeptide binding]; other site 1401659008522 putative substrate binding pocket (H-site) [chemical binding]; other site 1401659008523 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1401659008524 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1401659008525 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1401659008526 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1401659008527 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1401659008528 FeS/SAM binding site; other site 1401659008529 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 1401659008530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659008531 dimer interface [polypeptide binding]; other site 1401659008532 conserved gate region; other site 1401659008533 putative PBP binding loops; other site 1401659008534 ABC-ATPase subunit interface; other site 1401659008535 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 1401659008536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659008537 dimer interface [polypeptide binding]; other site 1401659008538 conserved gate region; other site 1401659008539 putative PBP binding loops; other site 1401659008540 ABC-ATPase subunit interface; other site 1401659008541 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 1401659008542 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 1401659008543 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1401659008544 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1401659008545 Walker A/P-loop; other site 1401659008546 ATP binding site [chemical binding]; other site 1401659008547 Q-loop/lid; other site 1401659008548 ABC transporter signature motif; other site 1401659008549 Walker B; other site 1401659008550 D-loop; other site 1401659008551 H-loop/switch region; other site 1401659008552 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1401659008553 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1401659008554 Walker A/P-loop; other site 1401659008555 ATP binding site [chemical binding]; other site 1401659008556 Q-loop/lid; other site 1401659008557 ABC transporter signature motif; other site 1401659008558 Walker B; other site 1401659008559 D-loop; other site 1401659008560 H-loop/switch region; other site 1401659008561 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1401659008562 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 1401659008563 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1401659008564 dimer interface [polypeptide binding]; other site 1401659008565 putative functional site; other site 1401659008566 putative MPT binding site; other site 1401659008567 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1401659008568 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1401659008569 ATP binding site [chemical binding]; other site 1401659008570 substrate interface [chemical binding]; other site 1401659008571 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1401659008572 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1401659008573 DNA binding site [nucleotide binding] 1401659008574 domain linker motif; other site 1401659008575 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1401659008576 ligand binding site [chemical binding]; other site 1401659008577 dimerization interface [polypeptide binding]; other site 1401659008578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659008579 D-galactonate transporter; Region: 2A0114; TIGR00893 1401659008580 putative substrate translocation pore; other site 1401659008581 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1401659008582 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1401659008583 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 1401659008584 putative active site [active] 1401659008585 putative catalytic site [active] 1401659008586 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1401659008587 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1401659008588 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1401659008589 Walker A/P-loop; other site 1401659008590 ATP binding site [chemical binding]; other site 1401659008591 Q-loop/lid; other site 1401659008592 ABC transporter signature motif; other site 1401659008593 Walker B; other site 1401659008594 D-loop; other site 1401659008595 H-loop/switch region; other site 1401659008596 ABC transporter; Region: ABC_tran_2; pfam12848 1401659008597 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1401659008598 L,D-transpeptidase; Provisional; Region: PRK10260 1401659008599 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1401659008600 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1401659008601 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1401659008602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659008603 putative substrate translocation pore; other site 1401659008604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659008605 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1401659008606 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1401659008607 HlyD family secretion protein; Region: HlyD_3; pfam13437 1401659008608 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 1401659008609 transmembrane helices; other site 1401659008610 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1401659008611 manganese transport regulator MntR; Provisional; Region: PRK11050 1401659008612 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1401659008613 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1401659008614 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1401659008615 Sulfatase; Region: Sulfatase; pfam00884 1401659008616 outer membrane protein X; Provisional; Region: ompX; PRK09408 1401659008617 threonine and homoserine efflux system; Provisional; Region: PRK10532 1401659008618 EamA-like transporter family; Region: EamA; pfam00892 1401659008619 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1401659008620 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1401659008621 dimerization interface [polypeptide binding]; other site 1401659008622 DPS ferroxidase diiron center [ion binding]; other site 1401659008623 ion pore; other site 1401659008624 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 1401659008625 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1401659008626 substrate binding pocket [chemical binding]; other site 1401659008627 membrane-bound complex binding site; other site 1401659008628 hinge residues; other site 1401659008629 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1401659008630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659008631 dimer interface [polypeptide binding]; other site 1401659008632 conserved gate region; other site 1401659008633 putative PBP binding loops; other site 1401659008634 ABC-ATPase subunit interface; other site 1401659008635 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 1401659008636 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1401659008637 Walker A/P-loop; other site 1401659008638 ATP binding site [chemical binding]; other site 1401659008639 Q-loop/lid; other site 1401659008640 ABC transporter signature motif; other site 1401659008641 Walker B; other site 1401659008642 D-loop; other site 1401659008643 H-loop/switch region; other site 1401659008644 putative mechanosensitive channel protein; Provisional; Region: PRK11465 1401659008645 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1401659008646 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 1401659008647 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1401659008648 S-adenosylmethionine binding site [chemical binding]; other site 1401659008649 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1401659008650 hypothetical protein; Provisional; Region: PRK11019 1401659008651 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 1401659008652 glycosyl transferase family protein; Provisional; Region: PRK08136 1401659008653 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1401659008654 Fimbrial protein; Region: Fimbrial; cl01416 1401659008655 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1401659008656 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1401659008657 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1401659008658 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1401659008659 PapC N-terminal domain; Region: PapC_N; pfam13954 1401659008660 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1401659008661 PapC C-terminal domain; Region: PapC_C; pfam13953 1401659008662 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1401659008663 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1401659008664 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 1401659008665 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1401659008666 DEAD_2; Region: DEAD_2; pfam06733 1401659008667 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1401659008668 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1401659008669 CAT RNA binding domain; Region: CAT_RBD; smart01061 1401659008670 PRD domain; Region: PRD; pfam00874 1401659008671 PRD domain; Region: PRD; pfam00874 1401659008672 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1401659008673 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1401659008674 active site turn [active] 1401659008675 phosphorylation site [posttranslational modification] 1401659008676 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1401659008677 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1401659008678 HPr interaction site; other site 1401659008679 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1401659008680 active site 1401659008681 phosphorylation site [posttranslational modification] 1401659008682 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1401659008683 beta-galactosidase; Region: BGL; TIGR03356 1401659008684 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1401659008685 beta-galactosidase; Region: BGL; TIGR03356 1401659008686 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1401659008687 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1401659008688 ATP binding site [chemical binding]; other site 1401659008689 Mg++ binding site [ion binding]; other site 1401659008690 motif III; other site 1401659008691 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1401659008692 nucleotide binding region [chemical binding]; other site 1401659008693 ATP-binding site [chemical binding]; other site 1401659008694 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 1401659008695 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1401659008696 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1401659008697 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1401659008698 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1401659008699 HlyD family secretion protein; Region: HlyD_3; pfam13437 1401659008700 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1401659008701 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1401659008702 Walker A/P-loop; other site 1401659008703 ATP binding site [chemical binding]; other site 1401659008704 Q-loop/lid; other site 1401659008705 ABC transporter signature motif; other site 1401659008706 Walker B; other site 1401659008707 D-loop; other site 1401659008708 H-loop/switch region; other site 1401659008709 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1401659008710 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1401659008711 Walker A/P-loop; other site 1401659008712 ATP binding site [chemical binding]; other site 1401659008713 Q-loop/lid; other site 1401659008714 ABC transporter signature motif; other site 1401659008715 Walker B; other site 1401659008716 D-loop; other site 1401659008717 H-loop/switch region; other site 1401659008718 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1401659008719 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1401659008720 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1401659008721 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1401659008722 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 1401659008723 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 1401659008724 putative catalytic site [active] 1401659008725 putative metal binding site [ion binding]; other site 1401659008726 putative phosphate binding site [ion binding]; other site 1401659008727 cardiolipin synthase 2; Provisional; Region: PRK11263 1401659008728 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1401659008729 putative active site [active] 1401659008730 catalytic site [active] 1401659008731 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1401659008732 putative active site [active] 1401659008733 catalytic site [active] 1401659008734 Predicted integral membrane protein [Function unknown]; Region: COG0392 1401659008735 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1401659008736 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1401659008737 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1401659008738 MoaE homodimer interface [polypeptide binding]; other site 1401659008739 MoaD interaction [polypeptide binding]; other site 1401659008740 active site residues [active] 1401659008741 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1401659008742 MoaE interaction surface [polypeptide binding]; other site 1401659008743 MoeB interaction surface [polypeptide binding]; other site 1401659008744 thiocarboxylated glycine; other site 1401659008745 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1401659008746 trimer interface [polypeptide binding]; other site 1401659008747 dimer interface [polypeptide binding]; other site 1401659008748 putative active site [active] 1401659008749 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1401659008750 MPT binding site; other site 1401659008751 trimer interface [polypeptide binding]; other site 1401659008752 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1401659008753 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1401659008754 FeS/SAM binding site; other site 1401659008755 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1401659008756 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1401659008757 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1401659008758 phosphate binding site [ion binding]; other site 1401659008759 putative substrate binding pocket [chemical binding]; other site 1401659008760 dimer interface [polypeptide binding]; other site 1401659008761 excinuclease ABC subunit B; Provisional; Region: PRK05298 1401659008762 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1401659008763 ATP binding site [chemical binding]; other site 1401659008764 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1401659008765 nucleotide binding region [chemical binding]; other site 1401659008766 ATP-binding site [chemical binding]; other site 1401659008767 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1401659008768 UvrB/uvrC motif; Region: UVR; pfam02151 1401659008769 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1401659008770 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1401659008771 Walker A/P-loop; other site 1401659008772 ATP binding site [chemical binding]; other site 1401659008773 Q-loop/lid; other site 1401659008774 ABC transporter signature motif; other site 1401659008775 Walker B; other site 1401659008776 D-loop; other site 1401659008777 H-loop/switch region; other site 1401659008778 AAA domain; Region: AAA_26; pfam13500 1401659008779 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 1401659008780 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1401659008781 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1401659008782 S-adenosylmethionine binding site [chemical binding]; other site 1401659008783 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1401659008784 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1401659008785 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1401659008786 catalytic residue [active] 1401659008787 biotin synthase; Provisional; Region: PRK15108 1401659008788 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1401659008789 FeS/SAM binding site; other site 1401659008790 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1401659008791 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 1401659008792 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1401659008793 inhibitor-cofactor binding pocket; inhibition site 1401659008794 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659008795 catalytic residue [active] 1401659008796 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1401659008797 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1401659008798 potential catalytic triad [active] 1401659008799 conserved cys residue [active] 1401659008800 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1401659008801 substrate binding site [chemical binding]; other site 1401659008802 acyl-CoA thioesterase; Provisional; Region: PRK10531 1401659008803 putative pectinesterase; Region: PLN02432; cl01911 1401659008804 6-phosphogluconolactonase; Provisional; Region: PRK11028 1401659008805 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 1401659008806 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1401659008807 motif II; other site 1401659008808 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1401659008809 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 1401659008810 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1401659008811 Walker A/P-loop; other site 1401659008812 ATP binding site [chemical binding]; other site 1401659008813 Q-loop/lid; other site 1401659008814 ABC transporter signature motif; other site 1401659008815 Walker B; other site 1401659008816 D-loop; other site 1401659008817 H-loop/switch region; other site 1401659008818 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1401659008819 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1401659008820 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659008821 dimer interface [polypeptide binding]; other site 1401659008822 conserved gate region; other site 1401659008823 putative PBP binding loops; other site 1401659008824 ABC-ATPase subunit interface; other site 1401659008825 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 1401659008826 molybdenum ABC transporter, periplasmic molybdate-binding protein; Region: modA; TIGR01256 1401659008827 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 1401659008828 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 1401659008829 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1401659008830 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1401659008831 TOBE domain; Region: TOBE; cl01440 1401659008832 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 1401659008833 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1401659008834 Walker A/P-loop; other site 1401659008835 ATP binding site [chemical binding]; other site 1401659008836 ABC transporter signature motif; other site 1401659008837 Walker B; other site 1401659008838 D-loop; other site 1401659008839 H-loop/switch region; other site 1401659008840 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1401659008841 Walker A/P-loop; other site 1401659008842 ATP binding site [chemical binding]; other site 1401659008843 Q-loop/lid; other site 1401659008844 ABC transporter signature motif; other site 1401659008845 Walker B; other site 1401659008846 D-loop; other site 1401659008847 H-loop/switch region; other site 1401659008848 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 1401659008849 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1401659008850 NAD binding site [chemical binding]; other site 1401659008851 homodimer interface [polypeptide binding]; other site 1401659008852 active site 1401659008853 substrate binding site [chemical binding]; other site 1401659008854 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 1401659008855 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1401659008856 dimer interface [polypeptide binding]; other site 1401659008857 active site 1401659008858 galactokinase; Provisional; Region: PRK05101 1401659008859 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1401659008860 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1401659008861 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1401659008862 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1401659008863 active site 1401659008864 catalytic residues [active] 1401659008865 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1401659008866 catalytic core [active] 1401659008867 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1401659008868 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1401659008869 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1401659008870 Cation efflux family; Region: Cation_efflux; cl00316 1401659008871 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 1401659008872 quinolinate synthetase; Provisional; Region: PRK09375 1401659008873 tol-pal system protein YbgF; Provisional; Region: PRK10803 1401659008874 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1401659008875 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1401659008876 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 1401659008877 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1401659008878 ligand binding site [chemical binding]; other site 1401659008879 translocation protein TolB; Provisional; Region: tolB; PRK03629 1401659008880 TolB amino-terminal domain; Region: TolB_N; pfam04052 1401659008881 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1401659008882 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1401659008883 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1401659008884 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 1401659008885 TolA C-terminal; Region: TolA; pfam06519 1401659008886 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1401659008887 colicin uptake protein TolR; Provisional; Region: PRK11024 1401659008888 colicin uptake protein TolQ; Provisional; Region: PRK10801 1401659008889 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1401659008890 active site 1401659008891 hypothetical protein; Provisional; Region: PRK10588 1401659008892 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 1401659008893 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 1401659008894 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1401659008895 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1401659008896 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1401659008897 DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764 1401659008898 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1401659008899 CoA binding domain; Region: CoA_binding; smart00881 1401659008900 CoA-ligase; Region: Ligase_CoA; pfam00549 1401659008901 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1401659008902 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1401659008903 CoA-ligase; Region: Ligase_CoA; pfam00549 1401659008904 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1401659008905 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1401659008906 E3 interaction surface; other site 1401659008907 lipoyl attachment site [posttranslational modification]; other site 1401659008908 e3 binding domain; Region: E3_binding; pfam02817 1401659008909 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1401659008910 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1401659008911 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1401659008912 TPP-binding site [chemical binding]; other site 1401659008913 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1401659008914 dimer interface [polypeptide binding]; other site 1401659008915 PYR/PP interface [polypeptide binding]; other site 1401659008916 TPP binding site [chemical binding]; other site 1401659008917 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1401659008918 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1401659008919 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 1401659008920 L-aspartate oxidase; Provisional; Region: PRK06175 1401659008921 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1401659008922 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 1401659008923 proximal heme binding site [chemical binding]; other site 1401659008924 cardiolipin binding site; other site 1401659008925 SdhC subunit interface [polypeptide binding]; other site 1401659008926 Iron-sulfur protein interface; other site 1401659008927 proximal quinone binding site [chemical binding]; other site 1401659008928 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1401659008929 Iron-sulfur protein interface; other site 1401659008930 proximal quinone binding site [chemical binding]; other site 1401659008931 SdhD (CybS) interface [polypeptide binding]; other site 1401659008932 proximal heme binding site [chemical binding]; other site 1401659008933 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1401659008934 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1401659008935 dimer interface [polypeptide binding]; other site 1401659008936 active site 1401659008937 citrylCoA binding site [chemical binding]; other site 1401659008938 NADH binding [chemical binding]; other site 1401659008939 cationic pore residues; other site 1401659008940 oxalacetate/citrate binding site [chemical binding]; other site 1401659008941 coenzyme A binding site [chemical binding]; other site 1401659008942 catalytic triad [active] 1401659008943 endonuclease VIII; Provisional; Region: PRK10445 1401659008944 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 1401659008945 DNA binding site [nucleotide binding] 1401659008946 catalytic residue [active] 1401659008947 putative catalytic residues [active] 1401659008948 H2TH interface [polypeptide binding]; other site 1401659008949 intercalation triad [nucleotide binding]; other site 1401659008950 substrate specificity determining residue; other site 1401659008951 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1401659008952 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1401659008953 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 1401659008954 Predicted membrane protein [Function unknown]; Region: COG3817 1401659008955 Protein of unknown function (DUF979); Region: DUF979; pfam06166 1401659008956 Protein of unknown function (DUF969); Region: DUF969; pfam06149 1401659008957 MarR family; Region: MarR_2; cl17246 1401659008958 LamB/YcsF family protein; Provisional; Region: PRK05406 1401659008959 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1401659008960 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1401659008961 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1401659008962 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1401659008963 metal-binding protein; Provisional; Region: PRK10799 1401659008964 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 1401659008965 DNA photolyase; Region: DNA_photolyase; pfam00875 1401659008966 Protein of unknown function (DUF523); Region: DUF523; pfam04463 1401659008967 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1401659008968 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 1401659008969 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 1401659008970 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1401659008971 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1401659008972 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1401659008973 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 1401659008974 sensor protein KdpD; Provisional; Region: PRK10490 1401659008975 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1401659008976 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1401659008977 Ligand Binding Site [chemical binding]; other site 1401659008978 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1401659008979 GAF domain; Region: GAF_3; pfam13492 1401659008980 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1401659008981 dimer interface [polypeptide binding]; other site 1401659008982 phosphorylation site [posttranslational modification] 1401659008983 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1401659008984 ATP binding site [chemical binding]; other site 1401659008985 Mg2+ binding site [ion binding]; other site 1401659008986 G-X-G motif; other site 1401659008987 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1401659008988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1401659008989 active site 1401659008990 phosphorylation site [posttranslational modification] 1401659008991 intermolecular recognition site; other site 1401659008992 dimerization interface [polypeptide binding]; other site 1401659008993 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1401659008994 DNA binding site [nucleotide binding] 1401659008995 ornithine decarboxylase; Provisional; Region: PRK13578 1401659008996 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1401659008997 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1401659008998 homodimer interface [polypeptide binding]; other site 1401659008999 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659009000 catalytic residue [active] 1401659009001 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1401659009002 putrescine transporter; Provisional; Region: potE; PRK10655 1401659009003 phosphoglucomutase; Validated; Region: PRK07564 1401659009004 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1401659009005 active site 1401659009006 substrate binding site [chemical binding]; other site 1401659009007 metal binding site [ion binding]; metal-binding site 1401659009008 replication initiation regulator SeqA; Provisional; Region: PRK11187 1401659009009 acyl-CoA esterase; Provisional; Region: PRK10673 1401659009010 PGAP1-like protein; Region: PGAP1; pfam07819 1401659009011 LexA regulated protein; Provisional; Region: PRK11675 1401659009012 flavodoxin FldA; Validated; Region: PRK09267 1401659009013 ferric uptake regulator; Provisional; Region: fur; PRK09462 1401659009014 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1401659009015 metal binding site 2 [ion binding]; metal-binding site 1401659009016 putative DNA binding helix; other site 1401659009017 metal binding site 1 [ion binding]; metal-binding site 1401659009018 dimer interface [polypeptide binding]; other site 1401659009019 structural Zn2+ binding site [ion binding]; other site 1401659009020 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 1401659009021 Putative carbohydrate binding domain; Region: CHB_HEX; smart01081 1401659009022 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 1401659009023 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 1401659009024 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a...; Region: GH20_Sm-chitobiase-like; cd06569 1401659009025 active site 1401659009026 C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847 1401659009027 outer membrane porin, OprD family; Region: OprD; pfam03573 1401659009028 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1401659009029 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1401659009030 active site 1401659009031 HIGH motif; other site 1401659009032 nucleotide binding site [chemical binding]; other site 1401659009033 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1401659009034 KMSKS motif; other site 1401659009035 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1401659009036 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 1401659009037 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1401659009038 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1401659009039 active site turn [active] 1401659009040 phosphorylation site [posttranslational modification] 1401659009041 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1401659009042 HPr interaction site; other site 1401659009043 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1401659009044 active site 1401659009045 phosphorylation site [posttranslational modification] 1401659009046 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1401659009047 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1401659009048 active site 1401659009049 trimer interface [polypeptide binding]; other site 1401659009050 allosteric site; other site 1401659009051 active site lid [active] 1401659009052 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1401659009053 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 1401659009054 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1401659009055 active site 1401659009056 dimer interface [polypeptide binding]; other site 1401659009057 MarR family; Region: MarR; pfam01047 1401659009058 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1401659009059 ROK family; Region: ROK; pfam00480 1401659009060 UMP phosphatase; Provisional; Region: PRK10444 1401659009061 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1401659009062 active site 1401659009063 motif I; other site 1401659009064 motif II; other site 1401659009065 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1401659009066 asparagine synthetase B; Provisional; Region: asnB; PRK09431 1401659009067 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1401659009068 active site 1401659009069 dimer interface [polypeptide binding]; other site 1401659009070 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1401659009071 Ligand Binding Site [chemical binding]; other site 1401659009072 Molecular Tunnel; other site 1401659009073 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 1401659009074 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1401659009075 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1401659009076 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1401659009077 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1401659009078 FeS/SAM binding site; other site 1401659009079 TRAM domain; Region: TRAM; pfam01938 1401659009080 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1401659009081 PhoH-like protein; Region: PhoH; pfam02562 1401659009082 metal-binding heat shock protein; Provisional; Region: PRK00016 1401659009083 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 1401659009084 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1401659009085 Transporter associated domain; Region: CorC_HlyC; smart01091 1401659009086 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1401659009087 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1401659009088 putative active site [active] 1401659009089 catalytic triad [active] 1401659009090 putative dimer interface [polypeptide binding]; other site 1401659009091 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 1401659009092 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1401659009093 substrate binding pocket [chemical binding]; other site 1401659009094 membrane-bound complex binding site; other site 1401659009095 hinge residues; other site 1401659009096 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1401659009097 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659009098 dimer interface [polypeptide binding]; other site 1401659009099 conserved gate region; other site 1401659009100 putative PBP binding loops; other site 1401659009101 ABC-ATPase subunit interface; other site 1401659009102 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1401659009103 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659009104 dimer interface [polypeptide binding]; other site 1401659009105 conserved gate region; other site 1401659009106 putative PBP binding loops; other site 1401659009107 ABC-ATPase subunit interface; other site 1401659009108 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1401659009109 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1401659009110 Walker A/P-loop; other site 1401659009111 ATP binding site [chemical binding]; other site 1401659009112 Q-loop/lid; other site 1401659009113 ABC transporter signature motif; other site 1401659009114 Walker B; other site 1401659009115 D-loop; other site 1401659009116 H-loop/switch region; other site 1401659009117 hypothetical protein; Provisional; Region: PRK11032 1401659009118 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1401659009119 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1401659009120 HIGH motif; other site 1401659009121 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1401659009122 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1401659009123 active site 1401659009124 KMSKS motif; other site 1401659009125 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1401659009126 tRNA binding surface [nucleotide binding]; other site 1401659009127 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1401659009128 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 1401659009129 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1401659009130 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1401659009131 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1401659009132 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1401659009133 active site 1401659009134 (T/H)XGH motif; other site 1401659009135 ribosome-associated protein; Provisional; Region: PRK11538 1401659009136 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 1401659009137 penicillin-binding protein 2; Provisional; Region: PRK10795 1401659009138 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1401659009139 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1401659009140 cell wall shape-determining protein; Provisional; Region: PRK10794 1401659009141 rare lipoprotein A; Provisional; Region: PRK10672 1401659009142 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1401659009143 Sporulation related domain; Region: SPOR; pfam05036 1401659009144 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 1401659009145 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1401659009146 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1401659009147 hypothetical protein; Provisional; Region: PRK04998 1401659009148 lipoate-protein ligase B; Provisional; Region: PRK14342 1401659009149 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 1401659009150 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659009151 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1401659009152 substrate binding pocket [chemical binding]; other site 1401659009153 dimerization interface [polypeptide binding]; other site 1401659009154 lipoyl synthase; Provisional; Region: PRK05481 1401659009155 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1401659009156 FeS/SAM binding site; other site 1401659009157 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 1401659009158 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1401659009159 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1401659009160 putative active site [active] 1401659009161 catalytic triad [active] 1401659009162 putative dimer interface [polypeptide binding]; other site 1401659009163 chromosome condensation membrane protein; Provisional; Region: PRK14196 1401659009164 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1401659009165 DNA-binding site [nucleotide binding]; DNA binding site 1401659009166 RNA-binding motif; other site 1401659009167 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 1401659009168 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 1401659009169 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1401659009170 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 1401659009171 B1 nucleotide binding pocket [chemical binding]; other site 1401659009172 B2 nucleotide binding pocket [chemical binding]; other site 1401659009173 CAS motifs; other site 1401659009174 active site 1401659009175 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1401659009176 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1401659009177 Ca binding site [ion binding]; other site 1401659009178 active site 1401659009179 catalytic site [active] 1401659009180 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1401659009181 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1401659009182 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1401659009183 Ca binding site [ion binding]; other site 1401659009184 active site 1401659009185 catalytic site [active] 1401659009186 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1401659009187 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1401659009188 Walker A/P-loop; other site 1401659009189 ATP binding site [chemical binding]; other site 1401659009190 Q-loop/lid; other site 1401659009191 ABC transporter signature motif; other site 1401659009192 Walker B; other site 1401659009193 D-loop; other site 1401659009194 H-loop/switch region; other site 1401659009195 TOBE domain; Region: TOBE_2; pfam08402 1401659009196 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1401659009197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659009198 dimer interface [polypeptide binding]; other site 1401659009199 conserved gate region; other site 1401659009200 putative PBP binding loops; other site 1401659009201 ABC-ATPase subunit interface; other site 1401659009202 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659009203 dimer interface [polypeptide binding]; other site 1401659009204 conserved gate region; other site 1401659009205 putative PBP binding loops; other site 1401659009206 ABC-ATPase subunit interface; other site 1401659009207 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1401659009208 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1401659009209 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1401659009210 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1401659009211 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1401659009212 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1401659009213 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1401659009214 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1401659009215 NAD binding site [chemical binding]; other site 1401659009216 catalytic Zn binding site [ion binding]; other site 1401659009217 structural Zn binding site [ion binding]; other site 1401659009218 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1401659009219 Ligand Binding Site [chemical binding]; other site 1401659009220 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1401659009221 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1401659009222 catalytic residue [active] 1401659009223 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1401659009224 catalytic residues [active] 1401659009225 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1401659009226 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1401659009227 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 1401659009228 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1401659009229 dimer interface [polypeptide binding]; other site 1401659009230 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1401659009231 catalytic triad [active] 1401659009232 peroxidatic and resolving cysteines [active] 1401659009233 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 1401659009234 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659009235 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1401659009236 methionine aminotransferase; Validated; Region: PRK09082 1401659009237 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1401659009238 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659009239 homodimer interface [polypeptide binding]; other site 1401659009240 catalytic residue [active] 1401659009241 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 1401659009242 intersubunit interface [polypeptide binding]; other site 1401659009243 active site 1401659009244 Zn2+ binding site [ion binding]; other site 1401659009245 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 1401659009246 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1401659009247 Cupin domain; Region: Cupin_2; cl17218 1401659009248 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1401659009249 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1401659009250 acyl-activating enzyme (AAE) consensus motif; other site 1401659009251 AMP binding site [chemical binding]; other site 1401659009252 MbtH-like protein; Region: MbtH; cl01279 1401659009253 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 1401659009254 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1401659009255 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1401659009256 outer membrane receptor FepA; Provisional; Region: PRK13524 1401659009257 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1401659009258 N-terminal plug; other site 1401659009259 ligand-binding site [chemical binding]; other site 1401659009260 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 1401659009261 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1401659009262 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1401659009263 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1401659009264 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 1401659009265 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1401659009266 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1401659009267 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 1401659009268 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1401659009269 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1401659009270 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 1401659009271 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 1401659009272 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1401659009273 MarR family; Region: MarR_2; pfam12802 1401659009274 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1401659009275 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1401659009276 Coenzyme A binding pocket [chemical binding]; other site 1401659009277 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1401659009278 active site residue [active] 1401659009279 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1401659009280 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1401659009281 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1401659009282 dimerization interface [polypeptide binding]; other site 1401659009283 putative DNA binding site [nucleotide binding]; other site 1401659009284 putative Zn2+ binding site [ion binding]; other site 1401659009285 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659009286 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1401659009287 putative substrate translocation pore; other site 1401659009288 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1401659009289 RES domain; Region: RES; cl02411 1401659009290 Predicted transcriptional regulators [Transcription]; Region: COG1733 1401659009291 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1401659009292 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1401659009293 classical (c) SDRs; Region: SDR_c; cd05233 1401659009294 NAD(P) binding site [chemical binding]; other site 1401659009295 active site 1401659009296 Helix-turn-helix domain; Region: HTH_18; pfam12833 1401659009297 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1401659009298 SnoaL-like domain; Region: SnoaL_2; pfam12680 1401659009299 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 1401659009300 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1401659009301 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1401659009302 homodimer interface [polypeptide binding]; other site 1401659009303 NADP binding site [chemical binding]; other site 1401659009304 substrate binding site [chemical binding]; other site 1401659009305 ribosome-associated protein; Provisional; Region: PRK11507 1401659009306 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1401659009307 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1401659009308 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1401659009309 active site turn [active] 1401659009310 phosphorylation site [posttranslational modification] 1401659009311 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 1401659009312 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1401659009313 DNA binding site [nucleotide binding] 1401659009314 domain linker motif; other site 1401659009315 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1401659009316 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1401659009317 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1401659009318 active site 1401659009319 HIGH motif; other site 1401659009320 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1401659009321 KMSKS motif; other site 1401659009322 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1401659009323 tRNA binding surface [nucleotide binding]; other site 1401659009324 anticodon binding site; other site 1401659009325 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1401659009326 substrate binding site [chemical binding]; other site 1401659009327 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1401659009328 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1401659009329 putative active site [active] 1401659009330 putative metal binding site [ion binding]; other site 1401659009331 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1401659009332 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1401659009333 ATP-grasp domain; Region: ATP-grasp; pfam02222 1401659009334 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 1401659009335 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1401659009336 homodimer interface [polypeptide binding]; other site 1401659009337 substrate-cofactor binding pocket; other site 1401659009338 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659009339 catalytic residue [active] 1401659009340 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1401659009341 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1401659009342 dimer interface [polypeptide binding]; other site 1401659009343 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659009344 catalytic residue [active] 1401659009345 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1401659009346 FOG: CBS domain [General function prediction only]; Region: COG0517 1401659009347 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 1401659009348 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 1401659009349 active site residue [active] 1401659009350 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1401659009351 FtsX-like permease family; Region: FtsX; pfam02687 1401659009352 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1401659009353 Walker A/P-loop; other site 1401659009354 ATP binding site [chemical binding]; other site 1401659009355 ABC transporter; Region: ABC_tran; pfam00005 1401659009356 Q-loop/lid; other site 1401659009357 ABC transporter signature motif; other site 1401659009358 Walker B; other site 1401659009359 D-loop; other site 1401659009360 H-loop/switch region; other site 1401659009361 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1401659009362 active site 1401659009363 catalytic triad [active] 1401659009364 oxyanion hole [active] 1401659009365 switch loop; other site 1401659009366 oxidoreductase; Provisional; Region: PRK08017 1401659009367 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1401659009368 NADP binding site [chemical binding]; other site 1401659009369 active site 1401659009370 steroid binding site; other site 1401659009371 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1401659009372 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1401659009373 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1401659009374 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1401659009375 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1401659009376 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 1401659009377 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 1401659009378 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1401659009379 DNA binding residues [nucleotide binding] 1401659009380 dimer interface [polypeptide binding]; other site 1401659009381 copper binding site [ion binding]; other site 1401659009382 copper exporting ATPase; Provisional; Region: copA; PRK10671 1401659009383 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1401659009384 metal-binding site [ion binding] 1401659009385 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1401659009386 metal-binding site [ion binding] 1401659009387 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1401659009388 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1401659009389 motif II; other site 1401659009390 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1401659009391 TraB family; Region: TraB; cl12050 1401659009392 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1401659009393 putative deacylase active site [active] 1401659009394 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 1401659009395 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 1401659009396 active site 1401659009397 metal binding site [ion binding]; metal-binding site 1401659009398 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1401659009399 putative cation:proton antiport protein; Provisional; Region: PRK10669 1401659009400 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 1401659009401 TrkA-N domain; Region: TrkA_N; pfam02254 1401659009402 inosine/guanosine kinase; Provisional; Region: PRK15074 1401659009403 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1401659009404 ferrochelatase; Reviewed; Region: hemH; PRK00035 1401659009405 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1401659009406 C-terminal domain interface [polypeptide binding]; other site 1401659009407 active site 1401659009408 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1401659009409 active site 1401659009410 N-terminal domain interface [polypeptide binding]; other site 1401659009411 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1401659009412 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1401659009413 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1401659009414 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1401659009415 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1401659009416 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1401659009417 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1401659009418 adenylate kinase; Reviewed; Region: adk; PRK00279 1401659009419 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1401659009420 AMP-binding site [chemical binding]; other site 1401659009421 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1401659009422 heat shock protein 90; Provisional; Region: PRK05218 1401659009423 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1401659009424 ATP binding site [chemical binding]; other site 1401659009425 Mg2+ binding site [ion binding]; other site 1401659009426 G-X-G motif; other site 1401659009427 recombination protein RecR; Reviewed; Region: recR; PRK00076 1401659009428 RecR protein; Region: RecR; pfam02132 1401659009429 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1401659009430 putative active site [active] 1401659009431 putative metal-binding site [ion binding]; other site 1401659009432 tetramer interface [polypeptide binding]; other site 1401659009433 putative major fimbrial protein SthE; Provisional; Region: PRK15292 1401659009434 Fimbrial protein; Region: Fimbrial; pfam00419 1401659009435 Fimbrial protein; Region: Fimbrial; cl01416 1401659009436 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1401659009437 PapC N-terminal domain; Region: PapC_N; pfam13954 1401659009438 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1401659009439 PapC C-terminal domain; Region: PapC_C; pfam13953 1401659009440 fimbrial chaperone protein PefD; Provisional; Region: PRK15211 1401659009441 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1401659009442 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1401659009443 Fimbrial protein; Region: Fimbrial; cl01416 1401659009444 hypothetical protein; Validated; Region: PRK00153 1401659009445 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1401659009446 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 1401659009447 Walker A motif; other site 1401659009448 ATP binding site [chemical binding]; other site 1401659009449 Walker B motif; other site 1401659009450 arginine finger; other site 1401659009451 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1401659009452 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 1401659009453 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 1401659009454 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1401659009455 active site 1401659009456 hypothetical protein; Provisional; Region: PRK10527 1401659009457 Primosomal replication protein priB and priC; Region: priB_priC; cl11483 1401659009458 hypothetical protein; Provisional; Region: PRK11038 1401659009459 hypothetical protein; Provisional; Region: PRK11281 1401659009460 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1401659009461 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 1401659009462 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1401659009463 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 1401659009464 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1401659009465 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1401659009466 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1401659009467 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1401659009468 HlyD family secretion protein; Region: HlyD_3; pfam13437 1401659009469 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 1401659009470 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1401659009471 Hha toxicity attenuator; Provisional; Region: PRK10667 1401659009472 gene expression modulator; Provisional; Region: PRK10945 1401659009473 maltose O-acetyltransferase; Provisional; Region: PRK10092 1401659009474 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1401659009475 active site 1401659009476 substrate binding site [chemical binding]; other site 1401659009477 trimer interface [polypeptide binding]; other site 1401659009478 CoA binding site [chemical binding]; other site 1401659009479 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 1401659009480 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1401659009481 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1401659009482 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1401659009483 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1401659009484 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1401659009485 dimer interface [polypeptide binding]; other site 1401659009486 putative CheW interface [polypeptide binding]; other site 1401659009487 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1401659009488 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1401659009489 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1401659009490 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1401659009491 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1401659009492 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1401659009493 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1401659009494 Walker A/P-loop; other site 1401659009495 ATP binding site [chemical binding]; other site 1401659009496 Q-loop/lid; other site 1401659009497 ABC transporter signature motif; other site 1401659009498 Walker B; other site 1401659009499 D-loop; other site 1401659009500 H-loop/switch region; other site 1401659009501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659009502 dimer interface [polypeptide binding]; other site 1401659009503 conserved gate region; other site 1401659009504 ABC-ATPase subunit interface; other site 1401659009505 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1401659009506 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1401659009507 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1401659009508 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1401659009509 Coenzyme A binding pocket [chemical binding]; other site 1401659009510 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1401659009511 Predicted membrane protein [Function unknown]; Region: COG2364 1401659009512 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1401659009513 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1401659009514 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1401659009515 DNA-binding site [nucleotide binding]; DNA binding site 1401659009516 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1401659009517 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659009518 homodimer interface [polypeptide binding]; other site 1401659009519 catalytic residue [active] 1401659009520 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 1401659009521 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 1401659009522 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 1401659009523 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 1401659009524 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1401659009525 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 1401659009526 CT1975-like protein; Region: Cas_CT1975; pfam09344 1401659009527 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 1401659009528 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 1401659009529 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1401659009530 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 1401659009531 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1401659009532 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1401659009533 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1401659009534 DNA binding site [nucleotide binding] 1401659009535 active site 1401659009536 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 1401659009537 acyl-CoA thioesterase II; Provisional; Region: PRK10526 1401659009538 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1401659009539 active site 1401659009540 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1401659009541 catalytic triad [active] 1401659009542 dimer interface [polypeptide binding]; other site 1401659009543 ammonium transporter; Provisional; Region: PRK10666 1401659009544 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 1401659009545 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1401659009546 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 1401659009547 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1401659009548 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1401659009549 Walker A/P-loop; other site 1401659009550 ATP binding site [chemical binding]; other site 1401659009551 Q-loop/lid; other site 1401659009552 ABC transporter signature motif; other site 1401659009553 Walker B; other site 1401659009554 D-loop; other site 1401659009555 H-loop/switch region; other site 1401659009556 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1401659009557 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1401659009558 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1401659009559 Walker A/P-loop; other site 1401659009560 ATP binding site [chemical binding]; other site 1401659009561 Q-loop/lid; other site 1401659009562 ABC transporter signature motif; other site 1401659009563 Walker B; other site 1401659009564 D-loop; other site 1401659009565 H-loop/switch region; other site 1401659009566 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1401659009567 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1401659009568 putative DNA binding site [nucleotide binding]; other site 1401659009569 putative Zn2+ binding site [ion binding]; other site 1401659009570 AsnC family; Region: AsnC_trans_reg; pfam01037 1401659009571 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1401659009572 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1401659009573 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1401659009574 catalytic residue [active] 1401659009575 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 1401659009576 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1401659009577 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1401659009578 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1401659009579 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1401659009580 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1401659009581 Ligand Binding Site [chemical binding]; other site 1401659009582 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1401659009583 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1401659009584 active site 1401659009585 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1401659009586 periplasmic folding chaperone; Provisional; Region: PRK10788 1401659009587 SurA N-terminal domain; Region: SurA_N_3; cl07813 1401659009588 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1401659009589 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1401659009590 IHF dimer interface [polypeptide binding]; other site 1401659009591 IHF - DNA interface [nucleotide binding]; other site 1401659009592 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 1401659009593 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1401659009594 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1401659009595 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1401659009596 Walker A motif; other site 1401659009597 ATP binding site [chemical binding]; other site 1401659009598 Walker B motif; other site 1401659009599 arginine finger; other site 1401659009600 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1401659009601 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1401659009602 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1401659009603 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1401659009604 Walker A motif; other site 1401659009605 ATP binding site [chemical binding]; other site 1401659009606 Walker B motif; other site 1401659009607 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1401659009608 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1401659009609 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1401659009610 oligomer interface [polypeptide binding]; other site 1401659009611 active site residues [active] 1401659009612 trigger factor; Provisional; Region: tig; PRK01490 1401659009613 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1401659009614 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1401659009615 transcriptional regulator BolA; Provisional; Region: PRK11628 1401659009616 hypothetical protein; Provisional; Region: PRK11627 1401659009617 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 1401659009618 muropeptide transporter; Reviewed; Region: ampG; PRK11902 1401659009619 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659009620 putative substrate translocation pore; other site 1401659009621 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1401659009622 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 1401659009623 nucleotide binding site [chemical binding]; other site 1401659009624 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1401659009625 SBD interface [polypeptide binding]; other site 1401659009626 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 1401659009627 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1401659009628 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1401659009629 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1401659009630 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1401659009631 D-pathway; other site 1401659009632 Putative ubiquinol binding site [chemical binding]; other site 1401659009633 Low-spin heme (heme b) binding site [chemical binding]; other site 1401659009634 Putative water exit pathway; other site 1401659009635 Binuclear center (heme o3/CuB) [ion binding]; other site 1401659009636 K-pathway; other site 1401659009637 Putative proton exit pathway; other site 1401659009638 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1401659009639 Subunit I/III interface [polypeptide binding]; other site 1401659009640 Subunit III/IV interface [polypeptide binding]; other site 1401659009641 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 1401659009642 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 1401659009643 UbiA prenyltransferase family; Region: UbiA; pfam01040 1401659009644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659009645 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1401659009646 putative substrate translocation pore; other site 1401659009647 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1401659009648 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1401659009649 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1401659009650 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1401659009651 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1401659009652 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 1401659009653 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1401659009654 conserved cys residue [active] 1401659009655 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 1401659009656 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1401659009657 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1401659009658 Ligand Binding Site [chemical binding]; other site 1401659009659 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1401659009660 active site residue [active] 1401659009661 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1401659009662 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1401659009663 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1401659009664 substrate binding pocket [chemical binding]; other site 1401659009665 chain length determination region; other site 1401659009666 substrate-Mg2+ binding site; other site 1401659009667 catalytic residues [active] 1401659009668 aspartate-rich region 1; other site 1401659009669 active site lid residues [active] 1401659009670 aspartate-rich region 2; other site 1401659009671 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1401659009672 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1401659009673 TPP-binding site; other site 1401659009674 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1401659009675 PYR/PP interface [polypeptide binding]; other site 1401659009676 dimer interface [polypeptide binding]; other site 1401659009677 TPP binding site [chemical binding]; other site 1401659009678 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1401659009679 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1401659009680 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1401659009681 active site 1401659009682 catalytic tetrad [active] 1401659009683 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1401659009684 tetramer interfaces [polypeptide binding]; other site 1401659009685 binuclear metal-binding site [ion binding]; other site 1401659009686 thiamine monophosphate kinase; Provisional; Region: PRK05731 1401659009687 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1401659009688 ATP binding site [chemical binding]; other site 1401659009689 dimerization interface [polypeptide binding]; other site 1401659009690 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1401659009691 putative RNA binding site [nucleotide binding]; other site 1401659009692 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1401659009693 homopentamer interface [polypeptide binding]; other site 1401659009694 active site 1401659009695 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 1401659009696 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1401659009697 catalytic motif [active] 1401659009698 Zn binding site [ion binding]; other site 1401659009699 RibD C-terminal domain; Region: RibD_C; cl17279 1401659009700 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1401659009701 ATP cone domain; Region: ATP-cone; pfam03477 1401659009702 hypothetical protein; Provisional; Region: PRK11530 1401659009703 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 1401659009704 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1401659009705 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1401659009706 Protein export membrane protein; Region: SecD_SecF; pfam02355 1401659009707 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1401659009708 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1401659009709 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1401659009710 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1401659009711 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1401659009712 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1401659009713 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 1401659009714 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1401659009715 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1401659009716 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 1401659009717 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 1401659009718 Membrane fusogenic activity; Region: BMFP; cl01115 1401659009719 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 1401659009720 maltodextrin glucosidase; Provisional; Region: PRK10785 1401659009721 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1401659009722 homodimer interface [polypeptide binding]; other site 1401659009723 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1401659009724 active site 1401659009725 homodimer interface [polypeptide binding]; other site 1401659009726 catalytic site [active] 1401659009727 putative proline-specific permease; Provisional; Region: proY; PRK10580 1401659009728 Spore germination protein; Region: Spore_permease; cl17796 1401659009729 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 1401659009730 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 1401659009731 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 1401659009732 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1401659009733 putative active site [active] 1401659009734 heme pocket [chemical binding]; other site 1401659009735 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1401659009736 dimer interface [polypeptide binding]; other site 1401659009737 phosphorylation site [posttranslational modification] 1401659009738 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1401659009739 ATP binding site [chemical binding]; other site 1401659009740 Mg2+ binding site [ion binding]; other site 1401659009741 G-X-G motif; other site 1401659009742 transcriptional regulator PhoB; Provisional; Region: PRK10161 1401659009743 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1401659009744 active site 1401659009745 phosphorylation site [posttranslational modification] 1401659009746 intermolecular recognition site; other site 1401659009747 dimerization interface [polypeptide binding]; other site 1401659009748 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1401659009749 DNA binding site [nucleotide binding] 1401659009750 exonuclease subunit SbcD; Provisional; Region: PRK10966 1401659009751 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1401659009752 active site 1401659009753 metal binding site [ion binding]; metal-binding site 1401659009754 DNA binding site [nucleotide binding] 1401659009755 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1401659009756 exonuclease subunit SbcC; Provisional; Region: PRK10246 1401659009757 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1401659009758 Walker A/P-loop; other site 1401659009759 ATP binding site [chemical binding]; other site 1401659009760 Q-loop/lid; other site 1401659009761 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1401659009762 ABC transporter signature motif; other site 1401659009763 Walker B; other site 1401659009764 D-loop; other site 1401659009765 H-loop/switch region; other site 1401659009766 fructokinase; Reviewed; Region: PRK09557 1401659009767 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1401659009768 nucleotide binding site [chemical binding]; other site 1401659009769 recombination associated protein; Reviewed; Region: rdgC; PRK00321 1401659009770 hypothetical protein; Provisional; Region: PRK10579 1401659009771 hypothetical protein; Provisional; Region: PRK10481 1401659009772 hypothetical protein; Provisional; Region: PRK10380 1401659009773 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1401659009774 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1401659009775 ADP binding site [chemical binding]; other site 1401659009776 magnesium binding site [ion binding]; other site 1401659009777 putative shikimate binding site; other site 1401659009778 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 1401659009779 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 1401659009780 Predicted membrane protein [Function unknown]; Region: COG2323 1401659009781 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1401659009782 pyrroline-5-carboxylate reductase; Region: PLN02688 1401659009783 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1401659009784 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659009785 putative substrate translocation pore; other site 1401659009786 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659009787 anti-RssB factor; Provisional; Region: PRK10244 1401659009788 drug efflux system protein MdtG; Provisional; Region: PRK09874 1401659009789 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659009790 putative substrate translocation pore; other site 1401659009791 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 1401659009792 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1401659009793 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1401659009794 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1401659009795 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 1401659009796 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 1401659009797 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 1401659009798 microcin B17 transporter; Reviewed; Region: PRK11098 1401659009799 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1401659009800 Isochorismatase family; Region: Isochorismatase; pfam00857 1401659009801 catalytic triad [active] 1401659009802 conserved cis-peptide bond; other site 1401659009803 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 1401659009804 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1401659009805 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 1401659009806 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 1401659009807 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1401659009808 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1401659009809 Competence-damaged protein; Region: CinA; pfam02464 1401659009810 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1401659009811 dimer interface [polypeptide binding]; other site 1401659009812 active site 1401659009813 Schiff base residues; other site 1401659009814 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1401659009815 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1401659009816 putative acyl-acceptor binding pocket; other site 1401659009817 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 1401659009818 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1401659009819 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 1401659009820 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1401659009821 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659009822 dimer interface [polypeptide binding]; other site 1401659009823 conserved gate region; other site 1401659009824 putative PBP binding loops; other site 1401659009825 ABC-ATPase subunit interface; other site 1401659009826 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 1401659009827 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1401659009828 Walker A/P-loop; other site 1401659009829 ATP binding site [chemical binding]; other site 1401659009830 Q-loop/lid; other site 1401659009831 ABC transporter signature motif; other site 1401659009832 Walker B; other site 1401659009833 D-loop; other site 1401659009834 H-loop/switch region; other site 1401659009835 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 1401659009836 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1401659009837 substrate binding pocket [chemical binding]; other site 1401659009838 membrane-bound complex binding site; other site 1401659009839 hinge residues; other site 1401659009840 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1401659009841 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1401659009842 S-methylmethionine transporter; Provisional; Region: PRK11387 1401659009843 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1401659009844 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1401659009845 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 1401659009846 4Fe-4S binding domain; Region: Fer4; pfam00037 1401659009847 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1401659009848 [4Fe-4S] binding site [ion binding]; other site 1401659009849 molybdopterin cofactor binding site; other site 1401659009850 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1401659009851 molybdopterin cofactor binding site; other site 1401659009852 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1401659009853 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1401659009854 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1401659009855 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1401659009856 Predicted ATPase [General function prediction only]; Region: COG1485 1401659009857 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1401659009858 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1401659009859 putative acyl-acceptor binding pocket; other site 1401659009860 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1401659009861 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1401659009862 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1401659009863 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 1401659009864 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1401659009865 dimer interface [polypeptide binding]; other site 1401659009866 ADP-ribose binding site [chemical binding]; other site 1401659009867 active site 1401659009868 nudix motif; other site 1401659009869 metal binding site [ion binding]; metal-binding site 1401659009870 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 1401659009871 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1401659009872 EAL domain; Region: EAL; pfam00563 1401659009873 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1401659009874 active site clefts [active] 1401659009875 zinc binding site [ion binding]; other site 1401659009876 dimer interface [polypeptide binding]; other site 1401659009877 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1401659009878 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1401659009879 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1401659009880 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1401659009881 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1401659009882 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1401659009883 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 1401659009884 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1401659009885 Trp docking motif [polypeptide binding]; other site 1401659009886 putative active site [active] 1401659009887 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1401659009888 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659009889 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1401659009890 putative effector binding pocket; other site 1401659009891 dimerization interface [polypeptide binding]; other site 1401659009892 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1401659009893 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1401659009894 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1401659009895 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659009896 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1401659009897 dimerization interface [polypeptide binding]; other site 1401659009898 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; pfam05870 1401659009899 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1401659009900 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1401659009901 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1401659009902 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1401659009903 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659009904 dimer interface [polypeptide binding]; other site 1401659009905 conserved gate region; other site 1401659009906 putative PBP binding loops; other site 1401659009907 ABC-ATPase subunit interface; other site 1401659009908 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1401659009909 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1401659009910 Walker A/P-loop; other site 1401659009911 ATP binding site [chemical binding]; other site 1401659009912 Q-loop/lid; other site 1401659009913 ABC transporter signature motif; other site 1401659009914 Walker B; other site 1401659009915 D-loop; other site 1401659009916 H-loop/switch region; other site 1401659009917 NIL domain; Region: NIL; pfam09383 1401659009918 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 1401659009919 malate dehydrogenase; Provisional; Region: PRK13529 1401659009920 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1401659009921 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1401659009922 NAD(P) binding site [chemical binding]; other site 1401659009923 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 1401659009924 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659009925 putative substrate translocation pore; other site 1401659009926 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 1401659009927 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1401659009928 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1401659009929 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1401659009930 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 1401659009931 lac repressor; Reviewed; Region: lacI; PRK09526 1401659009932 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1401659009933 DNA binding site [nucleotide binding] 1401659009934 domain linker motif; other site 1401659009935 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1401659009936 ligand binding site [chemical binding]; other site 1401659009937 dimerization interface (open form) [polypeptide binding]; other site 1401659009938 dimerization interface (closed form) [polypeptide binding]; other site 1401659009939 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1401659009940 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1401659009941 NAD(P) binding site [chemical binding]; other site 1401659009942 active site 1401659009943 Helix-turn-helix domain; Region: HTH_31; pfam13560 1401659009944 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 1401659009945 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1401659009946 putative NAD(P) binding site [chemical binding]; other site 1401659009947 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1401659009948 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1401659009949 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 1401659009950 homotrimer interaction site [polypeptide binding]; other site 1401659009951 putative active site [active] 1401659009952 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1401659009953 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1401659009954 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1401659009955 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1401659009956 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1401659009957 conserved cys residue [active] 1401659009958 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1401659009959 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1401659009960 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 1401659009961 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 1401659009962 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1401659009963 active site 1401659009964 dimer interface [polypeptide binding]; other site 1401659009965 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1401659009966 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 1401659009967 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 1401659009968 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 1401659009969 pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079 1401659009970 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 1401659009971 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1401659009972 FeS/SAM binding site; other site 1401659009973 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1401659009974 coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110 1401659009975 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1401659009976 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1401659009977 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1401659009978 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1401659009979 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 1401659009980 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1401659009981 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1401659009982 peptide binding site [polypeptide binding]; other site 1401659009983 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 1401659009984 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1401659009985 metal binding site [ion binding]; metal-binding site 1401659009986 dimer interface [polypeptide binding]; other site 1401659009987 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1401659009988 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1401659009989 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1401659009990 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1401659009991 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 1401659009992 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 1401659009993 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1401659009994 active site 1401659009995 DNA binding site [nucleotide binding] 1401659009996 Int/Topo IB signature motif; other site 1401659009997 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 1401659009998 HTH-like domain; Region: HTH_21; pfam13276 1401659009999 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1401659010000 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1401659010001 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1401659010002 MULE transposase domain; Region: MULE; pfam10551 1401659010003 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1401659010004 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1401659010005 putative dimer interface [polypeptide binding]; other site 1401659010006 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1401659010007 Clp amino terminal domain; Region: Clp_N; pfam02861 1401659010008 Clp amino terminal domain; Region: Clp_N; pfam02861 1401659010009 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1401659010010 Walker A motif; other site 1401659010011 ATP binding site [chemical binding]; other site 1401659010012 Walker B motif; other site 1401659010013 arginine finger; other site 1401659010014 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1401659010015 Walker A motif; other site 1401659010016 ATP binding site [chemical binding]; other site 1401659010017 Walker B motif; other site 1401659010018 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1401659010019 FtsH Extracellular; Region: FtsH_ext; pfam06480 1401659010020 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1401659010021 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1401659010022 Walker A motif; other site 1401659010023 ATP binding site [chemical binding]; other site 1401659010024 Walker B motif; other site 1401659010025 arginine finger; other site 1401659010026 Peptidase family M41; Region: Peptidase_M41; pfam01434 1401659010027 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1401659010028 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1401659010029 putative dimer interface [polypeptide binding]; other site 1401659010030 integrase; Provisional; Region: PRK09692 1401659010031 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1401659010032 active site 1401659010033 Int/Topo IB signature motif; other site 1401659010034 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1401659010035 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1401659010036 Ligand binding site; other site 1401659010037 Putative Catalytic site; other site 1401659010038 DXD motif; other site 1401659010039 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 1401659010040 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1401659010041 Putative phage tail protein; Region: Phage-tail_3; pfam13550 1401659010042 tape measure domain; Region: tape_meas_nterm; TIGR02675 1401659010043 Arc-like DNA binding domain; Region: Arc; pfam03869 1401659010044 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1401659010045 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 1401659010046 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 1401659010047 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1401659010048 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 1401659010049 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 1401659010050 large terminase protein; Provisional; Region: 17; PHA02533 1401659010051 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 1401659010052 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 1401659010053 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1401659010054 Antitermination protein; Region: Antiterm; pfam03589 1401659010055 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 1401659010056 Antitermination protein; Region: Antiterm; pfam03589 1401659010057 Endodeoxyribonuclease RusA; Region: RusA; cl01885 1401659010058 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442 1401659010059 NinB protein; Region: NinB; pfam05772 1401659010060 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1401659010061 replicative DNA helicase; Region: DnaB; TIGR00665 1401659010062 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1401659010063 Walker A motif; other site 1401659010064 ATP binding site [chemical binding]; other site 1401659010065 Walker B motif; other site 1401659010066 DNA binding loops [nucleotide binding] 1401659010067 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 1401659010068 ParB-like nuclease domain; Region: ParB; smart00470 1401659010069 KorB domain; Region: KorB; pfam08535 1401659010070 Bacteriophage CII protein; Region: Phage_CII; pfam05269 1401659010071 Prophage antirepressor [Transcription]; Region: COG3617 1401659010072 BRO family, N-terminal domain; Region: Bro-N; smart01040 1401659010073 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1401659010074 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1401659010075 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1401659010076 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1401659010077 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1401659010078 ERF superfamily; Region: ERF; pfam04404 1401659010079 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 1401659010080 Protein of unknown function (DUF2737); Region: DUF2737; pfam10930 1401659010081 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1401659010082 YfdX protein; Region: YfdX; pfam10938 1401659010083 YfdX protein; Region: YfdX; pfam10938 1401659010084 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1401659010085 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1401659010086 catalytic residues [active] 1401659010087 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1401659010088 TrkA-N domain; Region: TrkA_N; pfam02254 1401659010089 Phosphate-starvation-inducible E; Region: PsiE; pfam06146 1401659010090 Peptidase family M48; Region: Peptidase_M48; cl12018 1401659010091 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1401659010092 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1401659010093 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1401659010094 protein binding site [polypeptide binding]; other site 1401659010095 Transposase domain (DUF772); Region: DUF772; pfam05598 1401659010096 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1401659010097 Protein of unknown function (DUF 659); Region: DUF659; pfam04937 1401659010098 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1401659010099 putative transposase OrfB; Reviewed; Region: PHA02517 1401659010100 HTH-like domain; Region: HTH_21; pfam13276 1401659010101 Integrase core domain; Region: rve; pfam00665 1401659010102 Integrase core domain; Region: rve_2; pfam13333 1401659010103 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1401659010104 Transposase; Region: HTH_Tnp_1; pfam01527 1401659010105 Antirestriction protein; Region: Antirestrict; pfam03230 1401659010106 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1401659010107 MPN+ (JAMM) motif; other site 1401659010108 Zinc-binding site [ion binding]; other site 1401659010109 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 1401659010110 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 1401659010111 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1401659010112 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1401659010113 putative catalytic cysteine [active] 1401659010114 gamma-glutamyl kinase; Provisional; Region: PRK05429 1401659010115 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1401659010116 nucleotide binding site [chemical binding]; other site 1401659010117 homotetrameric interface [polypeptide binding]; other site 1401659010118 putative phosphate binding site [ion binding]; other site 1401659010119 putative allosteric binding site; other site 1401659010120 PUA domain; Region: PUA; pfam01472 1401659010121 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1401659010122 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1401659010123 trimer interface [polypeptide binding]; other site 1401659010124 eyelet of channel; other site 1401659010125 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 1401659010126 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 1401659010127 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1401659010128 active site 1401659010129 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 1401659010130 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 1401659010131 metal binding site [ion binding]; metal-binding site 1401659010132 dimer interface [polypeptide binding]; other site 1401659010133 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 1401659010134 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1401659010135 hypothetical protein; Reviewed; Region: PRK09588 1401659010136 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 1401659010137 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1401659010138 active site 1401659010139 DNA polymerase IV; Validated; Region: PRK02406 1401659010140 DNA binding site [nucleotide binding] 1401659010141 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1401659010142 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1401659010143 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1401659010144 putative active site [active] 1401659010145 putative dimer interface [polypeptide binding]; other site 1401659010146 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1401659010147 dimer interface [polypeptide binding]; other site 1401659010148 active site 1401659010149 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 1401659010150 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1401659010151 active site 1401659010152 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1401659010153 C-N hydrolase family amidase; Provisional; Region: PRK10438 1401659010154 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 1401659010155 putative active site [active] 1401659010156 catalytic triad [active] 1401659010157 dimer interface [polypeptide binding]; other site 1401659010158 multimer interface [polypeptide binding]; other site 1401659010159 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1401659010160 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1401659010161 active site 1401659010162 substrate binding site [chemical binding]; other site 1401659010163 catalytic site [active] 1401659010164 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1401659010165 RNA/DNA hybrid binding site [nucleotide binding]; other site 1401659010166 active site 1401659010167 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1401659010168 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1401659010169 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1401659010170 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1401659010171 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1401659010172 catalytic residue [active] 1401659010173 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1401659010174 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1401659010175 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1401659010176 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1401659010177 hypothetical protein; Provisional; Region: PRK08317 1401659010178 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1401659010179 S-adenosylmethionine binding site [chemical binding]; other site 1401659010180 hypothetical protein; Provisional; Region: PRK05421 1401659010181 putative catalytic site [active] 1401659010182 putative metal binding site [ion binding]; other site 1401659010183 putative phosphate binding site [ion binding]; other site 1401659010184 putative catalytic site [active] 1401659010185 putative phosphate binding site [ion binding]; other site 1401659010186 putative metal binding site [ion binding]; other site 1401659010187 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1401659010188 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659010189 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 1401659010190 putative effector binding pocket; other site 1401659010191 dimerization interface [polypeptide binding]; other site 1401659010192 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1401659010193 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1401659010194 active site 1401659010195 catalytic tetrad [active] 1401659010196 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 1401659010197 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1401659010198 active site 1401659010199 motif I; other site 1401659010200 motif II; other site 1401659010201 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1401659010202 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1401659010203 Walker A/P-loop; other site 1401659010204 ATP binding site [chemical binding]; other site 1401659010205 Q-loop/lid; other site 1401659010206 ABC transporter signature motif; other site 1401659010207 Walker B; other site 1401659010208 D-loop; other site 1401659010209 H-loop/switch region; other site 1401659010210 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1401659010211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659010212 dimer interface [polypeptide binding]; other site 1401659010213 conserved gate region; other site 1401659010214 ABC-ATPase subunit interface; other site 1401659010215 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 1401659010216 lipoprotein, YaeC family; Region: TIGR00363 1401659010217 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 1401659010218 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1401659010219 homodimer interaction site [polypeptide binding]; other site 1401659010220 cofactor binding site; other site 1401659010221 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1401659010222 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1401659010223 dimer interface [polypeptide binding]; other site 1401659010224 motif 1; other site 1401659010225 active site 1401659010226 motif 2; other site 1401659010227 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1401659010228 putative deacylase active site [active] 1401659010229 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1401659010230 active site 1401659010231 motif 3; other site 1401659010232 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1401659010233 anticodon binding site; other site 1401659010234 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 1401659010235 NlpE N-terminal domain; Region: NlpE; pfam04170 1401659010236 hypothetical protein; Provisional; Region: PRK09256 1401659010237 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1401659010238 YaeQ protein; Region: YaeQ; pfam07152 1401659010239 hypothetical protein; Provisional; Region: PRK04964 1401659010240 Rho-binding antiterminator; Provisional; Region: PRK11625 1401659010241 Cytochrome c553 [Energy production and conversion]; Region: COG2863 1401659010242 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 1401659010243 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1401659010244 Ligand Binding Site [chemical binding]; other site 1401659010245 TilS substrate binding domain; Region: TilS; pfam09179 1401659010246 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 1401659010247 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1401659010248 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1401659010249 putative metal binding site [ion binding]; other site 1401659010250 lysine decarboxylase LdcC; Provisional; Region: PRK15399 1401659010251 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1401659010252 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1401659010253 homodimer interface [polypeptide binding]; other site 1401659010254 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659010255 catalytic residue [active] 1401659010256 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1401659010257 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 1401659010258 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 1401659010259 putative sugar binding site [chemical binding]; other site 1401659010260 catalytic residues [active] 1401659010261 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1401659010262 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1401659010263 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1401659010264 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1401659010265 putative active site [active] 1401659010266 putative PHP Thumb interface [polypeptide binding]; other site 1401659010267 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1401659010268 generic binding surface II; other site 1401659010269 generic binding surface I; other site 1401659010270 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1401659010271 RNA/DNA hybrid binding site [nucleotide binding]; other site 1401659010272 active site 1401659010273 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1401659010274 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1401659010275 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1401659010276 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1401659010277 active site 1401659010278 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1401659010279 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1401659010280 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1401659010281 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1401659010282 trimer interface [polypeptide binding]; other site 1401659010283 active site 1401659010284 UDP-GlcNAc binding site [chemical binding]; other site 1401659010285 lipid binding site [chemical binding]; lipid-binding site 1401659010286 periplasmic chaperone; Provisional; Region: PRK10780 1401659010287 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1401659010288 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 1401659010289 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1401659010290 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1401659010291 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1401659010292 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1401659010293 Surface antigen; Region: Bac_surface_Ag; pfam01103 1401659010294 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1401659010295 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1401659010296 active site 1401659010297 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1401659010298 protein binding site [polypeptide binding]; other site 1401659010299 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1401659010300 protein binding site [polypeptide binding]; other site 1401659010301 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1401659010302 putative substrate binding region [chemical binding]; other site 1401659010303 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 1401659010304 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1401659010305 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1401659010306 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1401659010307 catalytic residue [active] 1401659010308 putative FPP diphosphate binding site; other site 1401659010309 putative FPP binding hydrophobic cleft; other site 1401659010310 dimer interface [polypeptide binding]; other site 1401659010311 putative IPP diphosphate binding site; other site 1401659010312 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1401659010313 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1401659010314 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1401659010315 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1401659010316 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1401659010317 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1401659010318 hinge region; other site 1401659010319 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1401659010320 putative nucleotide binding site [chemical binding]; other site 1401659010321 uridine monophosphate binding site [chemical binding]; other site 1401659010322 homohexameric interface [polypeptide binding]; other site 1401659010323 elongation factor Ts; Provisional; Region: tsf; PRK09377 1401659010324 UBA/TS-N domain; Region: UBA; pfam00627 1401659010325 Elongation factor TS; Region: EF_TS; pfam00889 1401659010326 Elongation factor TS; Region: EF_TS; pfam00889 1401659010327 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1401659010328 rRNA interaction site [nucleotide binding]; other site 1401659010329 S8 interaction site; other site 1401659010330 putative laminin-1 binding site; other site 1401659010331 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1401659010332 active site 1401659010333 PII uridylyl-transferase; Provisional; Region: PRK05007 1401659010334 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1401659010335 metal binding triad; other site 1401659010336 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1401659010337 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1401659010338 Zn2+ binding site [ion binding]; other site 1401659010339 Mg2+ binding site [ion binding]; other site 1401659010340 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1401659010341 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1401659010342 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1401659010343 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1401659010344 trimer interface [polypeptide binding]; other site 1401659010345 active site 1401659010346 substrate binding site [chemical binding]; other site 1401659010347 CoA binding site [chemical binding]; other site 1401659010348 hypothetical protein; Provisional; Region: PRK13677 1401659010349 serine endoprotease; Provisional; Region: PRK10942 1401659010350 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1401659010351 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1401659010352 protein binding site [polypeptide binding]; other site 1401659010353 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1401659010354 protein binding site [polypeptide binding]; other site 1401659010355 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 1401659010356 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1401659010357 Zn2+ binding site [ion binding]; other site 1401659010358 Mg2+ binding site [ion binding]; other site 1401659010359 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1401659010360 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1401659010361 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1401659010362 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 1401659010363 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1401659010364 cobalamin binding residues [chemical binding]; other site 1401659010365 putative BtuC binding residues; other site 1401659010366 dimer interface [polypeptide binding]; other site 1401659010367 hypothetical protein; Provisional; Region: PRK10578 1401659010368 UPF0126 domain; Region: UPF0126; pfam03458 1401659010369 UPF0126 domain; Region: UPF0126; pfam03458 1401659010370 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1401659010371 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1401659010372 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1401659010373 Cl- selectivity filter; other site 1401659010374 Cl- binding residues [ion binding]; other site 1401659010375 pore gating glutamate residue; other site 1401659010376 dimer interface [polypeptide binding]; other site 1401659010377 H+/Cl- coupling transport residue; other site 1401659010378 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1401659010379 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1401659010380 inhibitor-cofactor binding pocket; inhibition site 1401659010381 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659010382 catalytic residue [active] 1401659010383 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1401659010384 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1401659010385 ABC-ATPase subunit interface; other site 1401659010386 dimer interface [polypeptide binding]; other site 1401659010387 putative PBP binding regions; other site 1401659010388 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1401659010389 ABC-ATPase subunit interface; other site 1401659010390 dimer interface [polypeptide binding]; other site 1401659010391 putative PBP binding regions; other site 1401659010392 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1401659010393 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1401659010394 siderophore binding site; other site 1401659010395 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 1401659010396 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1401659010397 Walker A/P-loop; other site 1401659010398 ATP binding site [chemical binding]; other site 1401659010399 Q-loop/lid; other site 1401659010400 ABC transporter signature motif; other site 1401659010401 Walker B; other site 1401659010402 D-loop; other site 1401659010403 H-loop/switch region; other site 1401659010404 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1401659010405 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1401659010406 N-terminal plug; other site 1401659010407 ligand-binding site [chemical binding]; other site 1401659010408 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 1401659010409 Transglycosylase; Region: Transgly; pfam00912 1401659010410 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1401659010411 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 1401659010412 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1401659010413 ATP binding site [chemical binding]; other site 1401659010414 putative Mg++ binding site [ion binding]; other site 1401659010415 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1401659010416 nucleotide binding region [chemical binding]; other site 1401659010417 ATP-binding site [chemical binding]; other site 1401659010418 Helicase associated domain (HA2); Region: HA2; pfam04408 1401659010419 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1401659010420 2'-5' RNA ligase; Provisional; Region: PRK15124 1401659010421 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1401659010422 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1401659010423 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1401659010424 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1401659010425 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 1401659010426 active site 1401659010427 HIGH motif; other site 1401659010428 KMSKS motif; other site 1401659010429 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 1401659010430 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1401659010431 active site 1401659010432 NTP binding site [chemical binding]; other site 1401659010433 metal binding triad [ion binding]; metal-binding site 1401659010434 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1401659010435 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1401659010436 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1401659010437 catalytic center binding site [active] 1401659010438 ATP binding site [chemical binding]; other site 1401659010439 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1401659010440 oligomerization interface [polypeptide binding]; other site 1401659010441 active site 1401659010442 metal binding site [ion binding]; metal-binding site 1401659010443 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1401659010444 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1401659010445 active site 1401659010446 ATP-binding site [chemical binding]; other site 1401659010447 pantoate-binding site; other site 1401659010448 HXXH motif; other site 1401659010449 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1401659010450 tetramerization interface [polypeptide binding]; other site 1401659010451 active site 1401659010452 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1401659010453 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 1401659010454 putative active site [active] 1401659010455 putative metal binding site [ion binding]; other site 1401659010456 inner membrane transport permease; Provisional; Region: PRK15066 1401659010457 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1401659010458 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1401659010459 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1401659010460 Walker A/P-loop; other site 1401659010461 ATP binding site [chemical binding]; other site 1401659010462 Q-loop/lid; other site 1401659010463 ABC transporter signature motif; other site 1401659010464 Walker B; other site 1401659010465 D-loop; other site 1401659010466 H-loop/switch region; other site 1401659010467 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1401659010468 active site clefts [active] 1401659010469 zinc binding site [ion binding]; other site 1401659010470 dimer interface [polypeptide binding]; other site 1401659010471 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1401659010472 active site 1401659010473 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1401659010474 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 1401659010475 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1401659010476 Trp docking motif [polypeptide binding]; other site 1401659010477 putative active site [active] 1401659010478 multicopper oxidase; Provisional; Region: PRK10965 1401659010479 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1401659010480 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1401659010481 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 1401659010482 spermidine synthase; Provisional; Region: PRK00811 1401659010483 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1401659010484 S-adenosylmethionine binding site [chemical binding]; other site 1401659010485 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 1401659010486 hypothetical protein; Provisional; Region: PRK05248 1401659010487 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1401659010488 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1401659010489 substrate binding site [chemical binding]; other site 1401659010490 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1401659010491 substrate binding site [chemical binding]; other site 1401659010492 ligand binding site [chemical binding]; other site 1401659010493 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 1401659010494 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 1401659010495 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 1401659010496 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 1401659010497 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1401659010498 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1401659010499 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1401659010500 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1401659010501 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 1401659010502 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1401659010503 E3 interaction surface; other site 1401659010504 lipoyl attachment site [posttranslational modification]; other site 1401659010505 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1401659010506 E3 interaction surface; other site 1401659010507 lipoyl attachment site [posttranslational modification]; other site 1401659010508 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1401659010509 E3 interaction surface; other site 1401659010510 lipoyl attachment site [posttranslational modification]; other site 1401659010511 e3 binding domain; Region: E3_binding; pfam02817 1401659010512 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1401659010513 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1401659010514 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1401659010515 dimer interface [polypeptide binding]; other site 1401659010516 TPP-binding site [chemical binding]; other site 1401659010517 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 1401659010518 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1401659010519 DNA-binding site [nucleotide binding]; DNA binding site 1401659010520 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1401659010521 aromatic amino acid transporter; Provisional; Region: PRK10238 1401659010522 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1401659010523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659010524 putative substrate translocation pore; other site 1401659010525 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 1401659010526 active site 1401659010527 regulatory protein AmpE; Provisional; Region: PRK10987 1401659010528 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1401659010529 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1401659010530 amidase catalytic site [active] 1401659010531 substrate binding site [chemical binding]; other site 1401659010532 Zn binding residues [ion binding]; other site 1401659010533 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 1401659010534 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1401659010535 dimerization interface [polypeptide binding]; other site 1401659010536 active site 1401659010537 putative major pilin subunit; Provisional; Region: PRK10574 1401659010538 Pilin (bacterial filament); Region: Pilin; pfam00114 1401659010539 hypothetical protein; Provisional; Region: PRK10436 1401659010540 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1401659010541 Walker A motif; other site 1401659010542 ATP binding site [chemical binding]; other site 1401659010543 Walker B motif; other site 1401659010544 type IV pilin biogenesis protein; Provisional; Region: PRK10573 1401659010545 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1401659010546 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1401659010547 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 1401659010548 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1401659010549 active site 1401659010550 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1401659010551 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1401659010552 CoA-binding site [chemical binding]; other site 1401659010553 ATP-binding [chemical binding]; other site 1401659010554 hypothetical protein; Provisional; Region: PRK05287 1401659010555 DNA gyrase inhibitor; Reviewed; Region: PRK00418 1401659010556 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1401659010557 active site 1401659010558 8-oxo-dGMP binding site [chemical binding]; other site 1401659010559 nudix motif; other site 1401659010560 metal binding site [ion binding]; metal-binding site 1401659010561 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1401659010562 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1401659010563 SEC-C motif; Region: SEC-C; pfam02810 1401659010564 SecA regulator SecM; Provisional; Region: PRK02943 1401659010565 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1401659010566 cell division protein FtsZ; Validated; Region: PRK09330 1401659010567 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1401659010568 nucleotide binding site [chemical binding]; other site 1401659010569 SulA interaction site; other site 1401659010570 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 1401659010571 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1401659010572 Cell division protein FtsA; Region: FtsA; pfam14450 1401659010573 cell division protein FtsQ; Provisional; Region: PRK10775 1401659010574 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1401659010575 Cell division protein FtsQ; Region: FtsQ; pfam03799 1401659010576 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1401659010577 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1401659010578 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1401659010579 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1401659010580 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1401659010581 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1401659010582 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1401659010583 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1401659010584 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1401659010585 active site 1401659010586 homodimer interface [polypeptide binding]; other site 1401659010587 cell division protein FtsW; Provisional; Region: PRK10774 1401659010588 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 1401659010589 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1401659010590 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1401659010591 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1401659010592 Mg++ binding site [ion binding]; other site 1401659010593 putative catalytic motif [active] 1401659010594 putative substrate binding site [chemical binding]; other site 1401659010595 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 1401659010596 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1401659010597 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1401659010598 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1401659010599 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1401659010600 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1401659010601 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1401659010602 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1401659010603 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 1401659010604 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1401659010605 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1401659010606 cell division protein FtsL; Provisional; Region: PRK10772 1401659010607 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 1401659010608 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1401659010609 cell division protein MraZ; Reviewed; Region: PRK00326 1401659010610 MraZ protein; Region: MraZ; pfam02381 1401659010611 MraZ protein; Region: MraZ; pfam02381 1401659010612 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 1401659010613 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1401659010614 DNA binding site [nucleotide binding] 1401659010615 domain linker motif; other site 1401659010616 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1401659010617 dimerization interface [polypeptide binding]; other site 1401659010618 ligand binding site [chemical binding]; other site 1401659010619 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1401659010620 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1401659010621 putative valine binding site [chemical binding]; other site 1401659010622 dimer interface [polypeptide binding]; other site 1401659010623 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1401659010624 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 1401659010625 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1401659010626 PYR/PP interface [polypeptide binding]; other site 1401659010627 dimer interface [polypeptide binding]; other site 1401659010628 TPP binding site [chemical binding]; other site 1401659010629 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1401659010630 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1401659010631 TPP-binding site [chemical binding]; other site 1401659010632 dimer interface [polypeptide binding]; other site 1401659010633 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1401659010634 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659010635 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 1401659010636 putative substrate binding pocket [chemical binding]; other site 1401659010637 putative dimerization interface [polypeptide binding]; other site 1401659010638 2-isopropylmalate synthase; Validated; Region: PRK00915 1401659010639 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1401659010640 active site 1401659010641 catalytic residues [active] 1401659010642 metal binding site [ion binding]; metal-binding site 1401659010643 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1401659010644 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1401659010645 tartrate dehydrogenase; Region: TTC; TIGR02089 1401659010646 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1401659010647 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1401659010648 substrate binding site [chemical binding]; other site 1401659010649 ligand binding site [chemical binding]; other site 1401659010650 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1401659010651 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1401659010652 substrate binding site [chemical binding]; other site 1401659010653 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659010654 sugar efflux transporter; Region: 2A0120; TIGR00899 1401659010655 putative substrate translocation pore; other site 1401659010656 transcriptional regulator SgrR; Provisional; Region: PRK13626 1401659010657 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1401659010658 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1401659010659 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 1401659010660 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1401659010661 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 1401659010662 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659010663 dimer interface [polypeptide binding]; other site 1401659010664 conserved gate region; other site 1401659010665 putative PBP binding loops; other site 1401659010666 ABC-ATPase subunit interface; other site 1401659010667 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659010668 dimer interface [polypeptide binding]; other site 1401659010669 conserved gate region; other site 1401659010670 putative PBP binding loops; other site 1401659010671 ABC-ATPase subunit interface; other site 1401659010672 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 1401659010673 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 1401659010674 Walker A/P-loop; other site 1401659010675 ATP binding site [chemical binding]; other site 1401659010676 Q-loop/lid; other site 1401659010677 ABC transporter signature motif; other site 1401659010678 Walker B; other site 1401659010679 D-loop; other site 1401659010680 H-loop/switch region; other site 1401659010681 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1401659010682 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1401659010683 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 1401659010684 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1401659010685 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1401659010686 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1401659010687 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1401659010688 N- and C-terminal domain interface [polypeptide binding]; other site 1401659010689 ribulokinase; Provisional; Region: PRK04123 1401659010690 active site 1401659010691 carbohydrate binding site [chemical binding]; other site 1401659010692 MgATP binding site [chemical binding]; other site 1401659010693 homodimer interface [polypeptide binding]; other site 1401659010694 L-arabinose isomerase; Provisional; Region: PRK02929 1401659010695 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1401659010696 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1401659010697 trimer interface [polypeptide binding]; other site 1401659010698 putative substrate binding site [chemical binding]; other site 1401659010699 putative metal binding site [ion binding]; other site 1401659010700 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1401659010701 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1401659010702 intersubunit interface [polypeptide binding]; other site 1401659010703 active site 1401659010704 Zn2+ binding site [ion binding]; other site 1401659010705 DNA polymerase II; Reviewed; Region: PRK05762 1401659010706 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 1401659010707 active site 1401659010708 catalytic site [active] 1401659010709 substrate binding site [chemical binding]; other site 1401659010710 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 1401659010711 active site 1401659010712 metal-binding site 1401659010713 ATP-dependent helicase HepA; Validated; Region: PRK04914 1401659010714 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1401659010715 ATP binding site [chemical binding]; other site 1401659010716 putative Mg++ binding site [ion binding]; other site 1401659010717 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1401659010718 nucleotide binding region [chemical binding]; other site 1401659010719 ATP-binding site [chemical binding]; other site 1401659010720 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1401659010721 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1401659010722 active site 1401659010723 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 1401659010724 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1401659010725 putative metal binding site [ion binding]; other site 1401659010726 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1401659010727 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 1401659010728 OstA-like protein; Region: OstA; pfam03968 1401659010729 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1401659010730 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1401659010731 SurA N-terminal domain; Region: SurA_N; pfam09312 1401659010732 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1401659010733 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1401659010734 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1401659010735 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1401659010736 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1401659010737 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1401659010738 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1401659010739 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 1401659010740 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1401659010741 active site 1401659010742 metal binding site [ion binding]; metal-binding site 1401659010743 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1401659010744 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1401659010745 folate binding site [chemical binding]; other site 1401659010746 NADP+ binding site [chemical binding]; other site 1401659010747 LysE type translocator; Region: LysE; cl00565 1401659010748 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 1401659010749 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1401659010750 TrkA-N domain; Region: TrkA_N; pfam02254 1401659010751 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 1401659010752 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1401659010753 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1401659010754 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1401659010755 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1401659010756 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1401659010757 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1401659010758 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1401659010759 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1401659010760 IMP binding site; other site 1401659010761 dimer interface [polypeptide binding]; other site 1401659010762 interdomain contacts; other site 1401659010763 partial ornithine binding site; other site 1401659010764 Carbamoylphosphate synthase small subunit [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarA; COG0505 1401659010765 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1401659010766 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1401659010767 catalytic site [active] 1401659010768 subunit interface [polypeptide binding]; other site 1401659010769 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1401659010770 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1401659010771 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1401659010772 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 1401659010773 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1401659010774 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1401659010775 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659010776 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1401659010777 putative effector binding pocket; other site 1401659010778 dimerization interface [polypeptide binding]; other site 1401659010779 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1401659010780 active site 1401659010781 tetramer interface [polypeptide binding]; other site 1401659010782 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1401659010783 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1401659010784 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1401659010785 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1401659010786 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1401659010787 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1401659010788 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1401659010789 HIGH motif; other site 1401659010790 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1401659010791 active site 1401659010792 KMSKS motif; other site 1401659010793 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1401659010794 tRNA binding surface [nucleotide binding]; other site 1401659010795 anticodon binding site; other site 1401659010796 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1401659010797 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1401659010798 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1401659010799 active site 1401659010800 Riboflavin kinase; Region: Flavokinase; smart00904 1401659010801 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1401659010802 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 1401659010803 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659010804 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 1401659010805 putative dimerization interface [polypeptide binding]; other site 1401659010806 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 1401659010807 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 1401659010808 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1401659010809 active site 1401659010810 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 1401659010811 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1401659010812 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1401659010813 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1401659010814 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 1401659010815 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 1401659010816 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 1401659010817 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1401659010818 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659010819 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1401659010820 chaperone protein DnaJ; Provisional; Region: PRK10767 1401659010821 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1401659010822 HSP70 interaction site [polypeptide binding]; other site 1401659010823 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1401659010824 substrate binding site [polypeptide binding]; other site 1401659010825 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1401659010826 Zn binding sites [ion binding]; other site 1401659010827 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1401659010828 dimer interface [polypeptide binding]; other site 1401659010829 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1401659010830 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1401659010831 nucleotide binding site [chemical binding]; other site 1401659010832 hypothetical protein; Provisional; Region: PRK10659 1401659010833 metabolite-proton symporter; Region: 2A0106; TIGR00883 1401659010834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659010835 putative substrate translocation pore; other site 1401659010836 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1401659010837 MPT binding site; other site 1401659010838 trimer interface [polypeptide binding]; other site 1401659010839 transaldolase-like protein; Provisional; Region: PTZ00411 1401659010840 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1401659010841 active site 1401659010842 dimer interface [polypeptide binding]; other site 1401659010843 catalytic residue [active] 1401659010844 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1401659010845 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1401659010846 hypothetical protein; Validated; Region: PRK02101 1401659010847 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1401659010848 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1401659010849 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659010850 catalytic residue [active] 1401659010851 homoserine kinase; Provisional; Region: PRK01212 1401659010852 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1401659010853 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1401659010854 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 1401659010855 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1401659010856 putative catalytic residues [active] 1401659010857 putative nucleotide binding site [chemical binding]; other site 1401659010858 putative aspartate binding site [chemical binding]; other site 1401659010859 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 1401659010860 dimer interface [polypeptide binding]; other site 1401659010861 putative threonine allosteric regulatory site; other site 1401659010862 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 1401659010863 putative threonine allosteric regulatory site; other site 1401659010864 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1401659010865 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1401659010866 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1401659010867 putative RNA methyltransferase; Provisional; Region: PRK10433 1401659010868 two-component response regulator; Provisional; Region: PRK11173 1401659010869 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1401659010870 active site 1401659010871 phosphorylation site [posttranslational modification] 1401659010872 intermolecular recognition site; other site 1401659010873 dimerization interface [polypeptide binding]; other site 1401659010874 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1401659010875 DNA binding site [nucleotide binding] 1401659010876 inner membrane protein; Provisional; Region: PRK11715 1401659010877 sensory histidine kinase CreC; Provisional; Region: PRK11100 1401659010878 HAMP domain; Region: HAMP; pfam00672 1401659010879 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1401659010880 dimer interface [polypeptide binding]; other site 1401659010881 phosphorylation site [posttranslational modification] 1401659010882 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1401659010883 ATP binding site [chemical binding]; other site 1401659010884 Mg2+ binding site [ion binding]; other site 1401659010885 G-X-G motif; other site 1401659010886 DNA-binding response regulator CreB; Provisional; Region: PRK11083 1401659010887 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1401659010888 active site 1401659010889 phosphorylation site [posttranslational modification] 1401659010890 intermolecular recognition site; other site 1401659010891 dimerization interface [polypeptide binding]; other site 1401659010892 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1401659010893 DNA binding site [nucleotide binding] 1401659010894 hypothetical protein; Provisional; Region: PRK10756 1401659010895 CreA protein; Region: CreA; pfam05981 1401659010896 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 1401659010897 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1401659010898 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1401659010899 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1401659010900 catalytic core [active] 1401659010901 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 1401659010902 Trp operon repressor; Provisional; Region: PRK01381 1401659010903 lytic murein transglycosylase; Provisional; Region: PRK11619 1401659010904 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1401659010905 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1401659010906 catalytic residue [active] 1401659010907 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1401659010908 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1401659010909 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1401659010910 ABC transporter; Region: ABC_tran_2; pfam12848 1401659010911 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1401659010912 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 1401659010913 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 1401659010914 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1401659010915 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1401659010916 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 1401659010917 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1401659010918 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 1401659010919 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 1401659010920 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1401659010921 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1401659010922 active site 1401659010923 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1401659010924 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1401659010925 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1401659010926 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1401659010927 binding surface 1401659010928 TPR motif; other site 1401659010929 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1401659010930 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1401659010931 Walker A/P-loop; other site 1401659010932 ATP binding site [chemical binding]; other site 1401659010933 Q-loop/lid; other site 1401659010934 ABC transporter signature motif; other site 1401659010935 Walker B; other site 1401659010936 D-loop; other site 1401659010937 H-loop/switch region; other site 1401659010938 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1401659010939 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1401659010940 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659010941 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1401659010942 putative effector binding pocket; other site 1401659010943 dimerization interface [polypeptide binding]; other site 1401659010944 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1401659010945 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1401659010946 putative NAD(P) binding site [chemical binding]; other site 1401659010947 dimer interface [polypeptide binding]; other site 1401659010948 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1401659010949 non-specific DNA binding site [nucleotide binding]; other site 1401659010950 salt bridge; other site 1401659010951 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 1401659010952 sequence-specific DNA binding site [nucleotide binding]; other site 1401659010953 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 1401659010954 active site 1401659010955 (T/H)XGH motif; other site 1401659010956 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1401659010957 DNA repair protein RadA; Region: sms; TIGR00416 1401659010958 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1401659010959 Walker A motif/ATP binding site; other site 1401659010960 ATP binding site [chemical binding]; other site 1401659010961 Walker B motif; other site 1401659010962 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1401659010963 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 1401659010964 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1401659010965 motif II; other site 1401659010966 hypothetical protein; Provisional; Region: PRK11246 1401659010967 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 1401659010968 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1401659010969 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1401659010970 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1401659010971 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1401659010972 phosphopentomutase; Provisional; Region: PRK05362 1401659010973 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1401659010974 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1401659010975 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1401659010976 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1401659010977 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1401659010978 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1401659010979 intersubunit interface [polypeptide binding]; other site 1401659010980 active site 1401659010981 catalytic residue [active] 1401659010982 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1401659010983 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1401659010984 Nucleoside recognition; Region: Gate; pfam07670 1401659010985 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1401659010986 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1401659010987 active site 1401659010988 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1401659010989 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1401659010990 active site 1401659010991 nucleophile elbow; other site 1401659010992 periplasmic protein; Provisional; Region: PRK10568 1401659010993 BON domain; Region: BON; pfam04972 1401659010994 BON domain; Region: BON; pfam04972 1401659010995 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1401659010996 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1401659010997 G1 box; other site 1401659010998 putative GEF interaction site [polypeptide binding]; other site 1401659010999 GTP/Mg2+ binding site [chemical binding]; other site 1401659011000 Switch I region; other site 1401659011001 G2 box; other site 1401659011002 G3 box; other site 1401659011003 Switch II region; other site 1401659011004 G4 box; other site 1401659011005 G5 box; other site 1401659011006 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1401659011007 dUMP phosphatase; Provisional; Region: PRK09449 1401659011008 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1401659011009 motif II; other site 1401659011010 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 1401659011011 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1401659011012 Coenzyme A binding pocket [chemical binding]; other site 1401659011013 DNA polymerase III psi subunit; Region: DNA_III_psi; pfam03603 1401659011014 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 1401659011015 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 1401659011016 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1401659011017 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 1401659011018 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1401659011019 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1401659011020 metal binding site [ion binding]; metal-binding site 1401659011021 active site 1401659011022 I-site; other site 1401659011023 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 1401659011024 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1401659011025 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1401659011026 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1401659011027 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1401659011028 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1401659011029 putative deacylase active site [active] 1401659011030 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 1401659011031 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1401659011032 DNA binding residues [nucleotide binding] 1401659011033 dimerization interface [polypeptide binding]; other site 1401659011034 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1401659011035 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1401659011036 DNA binding residues [nucleotide binding] 1401659011037 dimerization interface [polypeptide binding]; other site 1401659011038 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1401659011039 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1401659011040 hypothetical protein; Provisional; Region: PRK09917 1401659011041 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1401659011042 MarR family; Region: MarR; pfam01047 1401659011043 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1401659011044 primosomal protein DnaI; Provisional; Region: PRK02854 1401659011045 DNA replication protein DnaC; Validated; Region: PRK07952 1401659011046 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1401659011047 Walker A motif; other site 1401659011048 ATP binding site [chemical binding]; other site 1401659011049 Walker B motif; other site 1401659011050 phosphoglycerol transferase I; Provisional; Region: PRK03776 1401659011051 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1401659011052 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1401659011053 GAF domain; Region: GAF; pfam01590 1401659011054 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1401659011055 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1401659011056 metal binding site [ion binding]; metal-binding site 1401659011057 active site 1401659011058 I-site; other site 1401659011059 HAMP domain; Region: HAMP; pfam00672 1401659011060 dimerization interface [polypeptide binding]; other site 1401659011061 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1401659011062 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1401659011063 metal binding site [ion binding]; metal-binding site 1401659011064 active site 1401659011065 I-site; other site 1401659011066 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1401659011067 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1401659011068 dimer interface [polypeptide binding]; other site 1401659011069 ligand binding site [chemical binding]; other site 1401659011070 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1401659011071 dimerization interface [polypeptide binding]; other site 1401659011072 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1401659011073 dimer interface [polypeptide binding]; other site 1401659011074 putative CheW interface [polypeptide binding]; other site 1401659011075 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 1401659011076 catalytic triad [active] 1401659011077 putative active site [active] 1401659011078 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1401659011079 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1401659011080 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1401659011081 cytosine deaminase; Provisional; Region: PRK09230 1401659011082 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1401659011083 active site 1401659011084 cytosine permease; Provisional; Region: codB; PRK11017 1401659011085 Na binding site [ion binding]; other site 1401659011086 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 1401659011087 beta-galactosidase; Region: BGL; TIGR03356 1401659011088 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 1401659011089 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1401659011090 active site turn [active] 1401659011091 phosphorylation site [posttranslational modification] 1401659011092 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1401659011093 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1401659011094 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1401659011095 DNA binding site [nucleotide binding] 1401659011096 domain linker motif; other site 1401659011097 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1401659011098 dimerization interface (closed form) [polypeptide binding]; other site 1401659011099 ligand binding site [chemical binding]; other site 1401659011100 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 1401659011101 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1401659011102 HlyD family secretion protein; Region: HlyD_3; pfam13437 1401659011103 transcriptional regulator SlyA; Provisional; Region: PRK03573 1401659011104 MarR family; Region: MarR_2; cl17246 1401659011105 lac repressor; Reviewed; Region: lacI; PRK09526 1401659011106 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1401659011107 DNA binding site [nucleotide binding] 1401659011108 domain linker motif; other site 1401659011109 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1401659011110 ligand binding site [chemical binding]; other site 1401659011111 dimerization interface (open form) [polypeptide binding]; other site 1401659011112 dimerization interface (closed form) [polypeptide binding]; other site 1401659011113 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1401659011114 trimer interface; other site 1401659011115 sugar binding site [chemical binding]; other site 1401659011116 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1401659011117 active site turn [active] 1401659011118 phosphorylation site [posttranslational modification] 1401659011119 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1401659011120 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1401659011121 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1401659011122 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1401659011123 Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism]; Region: COG3867 1401659011124 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1401659011125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659011126 dimer interface [polypeptide binding]; other site 1401659011127 conserved gate region; other site 1401659011128 putative PBP binding loops; other site 1401659011129 ABC-ATPase subunit interface; other site 1401659011130 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659011131 dimer interface [polypeptide binding]; other site 1401659011132 conserved gate region; other site 1401659011133 ABC-ATPase subunit interface; other site 1401659011134 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1401659011135 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1401659011136 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1401659011137 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1401659011138 Walker A/P-loop; other site 1401659011139 ATP binding site [chemical binding]; other site 1401659011140 Q-loop/lid; other site 1401659011141 ABC transporter signature motif; other site 1401659011142 Walker B; other site 1401659011143 D-loop; other site 1401659011144 H-loop/switch region; other site 1401659011145 TOBE domain; Region: TOBE; cl01440 1401659011146 TOBE domain; Region: TOBE_2; pfam08402 1401659011147 endoribonuclease SymE; Provisional; Region: PRK13605 1401659011148 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 1401659011149 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1401659011150 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1401659011151 DNA-binding site [nucleotide binding]; DNA binding site 1401659011152 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1401659011153 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659011154 homodimer interface [polypeptide binding]; other site 1401659011155 catalytic residue [active] 1401659011156 Protein of unknown function (DUF445); Region: DUF445; pfam04286 1401659011157 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 1401659011158 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1401659011159 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1401659011160 dimer interface [polypeptide binding]; other site 1401659011161 active site 1401659011162 metal binding site [ion binding]; metal-binding site 1401659011163 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1401659011164 DNA cytosine methylase; Provisional; Region: PRK10458 1401659011165 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1401659011166 cofactor binding site; other site 1401659011167 DNA binding site [nucleotide binding] 1401659011168 substrate interaction site [chemical binding]; other site 1401659011169 N-terminal domain of type IIE restriction endonuclease EcoRII and similar proteins; Region: EcoRII_N; cd10016 1401659011170 DNA binding site [nucleotide binding] 1401659011171 EcoRII C terminal; Region: EcoRII-C; pfam09019 1401659011172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 1401659011173 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 1401659011174 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1401659011175 active site 1401659011176 metal binding site [ion binding]; metal-binding site 1401659011177 interdomain interaction site; other site 1401659011178 D5 N terminal like; Region: D5_N; smart00885 1401659011179 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 1401659011180 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 1401659011181 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1401659011182 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 1401659011183 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 1401659011184 TIR domain; Region: TIR_2; pfam13676 1401659011185 integrase; Provisional; Region: PRK09692 1401659011186 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1401659011187 active site 1401659011188 Int/Topo IB signature motif; other site 1401659011189 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1401659011190 active site 1401659011191 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1401659011192 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1401659011193 S-adenosylmethionine binding site [chemical binding]; other site 1401659011194 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1401659011195 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1401659011196 DNA binding residues [nucleotide binding] 1401659011197 dimerization interface [polypeptide binding]; other site 1401659011198 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 1401659011199 active site 1401659011200 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1401659011201 catalytic residues [active] 1401659011202 Protein of unknown function (DUF2589); Region: DUF2589; pfam11655 1401659011203 Protein of unknown function (DUF2589); Region: DUF2589; pfam11655 1401659011204 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1401659011205 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1401659011206 putative NAD(P) binding site [chemical binding]; other site 1401659011207 putative substrate binding site [chemical binding]; other site 1401659011208 catalytic Zn binding site [ion binding]; other site 1401659011209 structural Zn binding site [ion binding]; other site 1401659011210 dimer interface [polypeptide binding]; other site 1401659011211 dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361 1401659011212 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1401659011213 DAK2 domain; Region: Dak2; pfam02734 1401659011214 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 1401659011215 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1401659011216 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 1401659011217 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1401659011218 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1401659011219 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1401659011220 interface (dimer of trimers) [polypeptide binding]; other site 1401659011221 Substrate-binding/catalytic site; other site 1401659011222 Zn-binding sites [ion binding]; other site 1401659011223 DNA polymerase III subunit chi; Validated; Region: PRK05728 1401659011224 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1401659011225 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1401659011226 HIGH motif; other site 1401659011227 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1401659011228 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1401659011229 active site 1401659011230 KMSKS motif; other site 1401659011231 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1401659011232 tRNA binding surface [nucleotide binding]; other site 1401659011233 anticodon binding site; other site 1401659011234 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1401659011235 Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987 1401659011236 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1401659011237 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1401659011238 Coenzyme A binding pocket [chemical binding]; other site 1401659011239 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1401659011240 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 1401659011241 active site 1401659011242 dinuclear metal binding site [ion binding]; other site 1401659011243 dimerization interface [polypeptide binding]; other site 1401659011244 RNase E inhibitor protein; Provisional; Region: PRK11191 1401659011245 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 1401659011246 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1401659011247 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1401659011248 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1401659011249 arginine deiminase; Provisional; Region: PRK01388 1401659011250 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1401659011251 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1401659011252 putative substrate binding site [chemical binding]; other site 1401659011253 nucleotide binding site [chemical binding]; other site 1401659011254 nucleotide binding site [chemical binding]; other site 1401659011255 homodimer interface [polypeptide binding]; other site 1401659011256 ornithine carbamoyltransferase; Validated; Region: PRK02102 1401659011257 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1401659011258 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1401659011259 Predicted membrane protein [Function unknown]; Region: COG1288 1401659011260 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1401659011261 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1401659011262 Arginine repressor [Transcription]; Region: ArgR; COG1438 1401659011263 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1401659011264 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 1401659011265 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1401659011266 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1401659011267 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 1401659011268 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 1401659011269 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 1401659011270 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1401659011271 homotrimer interaction site [polypeptide binding]; other site 1401659011272 putative active site [active] 1401659011273 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 1401659011274 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 1401659011275 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1401659011276 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 1401659011277 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1401659011278 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 1401659011279 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1401659011280 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1401659011281 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1401659011282 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1401659011283 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 1401659011284 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 1401659011285 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 1401659011286 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1401659011287 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1401659011288 fec operon regulator FecR; Reviewed; Region: PRK09774 1401659011289 FecR protein; Region: FecR; pfam04773 1401659011290 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 1401659011291 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1401659011292 N-terminal plug; other site 1401659011293 ligand-binding site [chemical binding]; other site 1401659011294 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 1401659011295 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1401659011296 siderophore binding site; other site 1401659011297 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1401659011298 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1401659011299 dimer interface [polypeptide binding]; other site 1401659011300 ABC-ATPase subunit interface; other site 1401659011301 putative PBP binding regions; other site 1401659011302 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1401659011303 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1401659011304 ABC-ATPase subunit interface; other site 1401659011305 dimer interface [polypeptide binding]; other site 1401659011306 putative PBP binding regions; other site 1401659011307 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 1401659011308 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1401659011309 Walker A/P-loop; other site 1401659011310 ATP binding site [chemical binding]; other site 1401659011311 Q-loop/lid; other site 1401659011312 ABC transporter signature motif; other site 1401659011313 Walker B; other site 1401659011314 D-loop; other site 1401659011315 H-loop/switch region; other site 1401659011316 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1401659011317 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1401659011318 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1401659011319 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1401659011320 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1401659011321 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1401659011322 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1401659011323 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1401659011324 putative NAD(P) binding site [chemical binding]; other site 1401659011325 dimer interface [polypeptide binding]; other site 1401659011326 lac repressor; Reviewed; Region: lacI; PRK09526 1401659011327 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1401659011328 DNA binding site [nucleotide binding] 1401659011329 domain linker motif; other site 1401659011330 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1401659011331 ligand binding site [chemical binding]; other site 1401659011332 dimerization interface (open form) [polypeptide binding]; other site 1401659011333 dimerization interface (closed form) [polypeptide binding]; other site 1401659011334 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 1401659011335 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1401659011336 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1401659011337 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1401659011338 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 1401659011339 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 1401659011340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659011341 putative substrate translocation pore; other site 1401659011342 Maltose acetyltransferase; Region: Mac; pfam12464 1401659011343 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 1401659011344 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1401659011345 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 1401659011346 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 1401659011347 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 1401659011348 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 1401659011349 NAD binding site [chemical binding]; other site 1401659011350 catalytic Zn binding site [ion binding]; other site 1401659011351 structural Zn binding site [ion binding]; other site 1401659011352 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1401659011353 dimerization interface [polypeptide binding]; other site 1401659011354 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1401659011355 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1401659011356 active site 1401659011357 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1401659011358 EamA-like transporter family; Region: EamA; pfam00892 1401659011359 EamA-like transporter family; Region: EamA; pfam00892 1401659011360 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1401659011361 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1401659011362 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1401659011363 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1401659011364 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1401659011365 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1401659011366 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1401659011367 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1401659011368 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1401659011369 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1401659011370 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1401659011371 FMN binding site [chemical binding]; other site 1401659011372 active site 1401659011373 substrate binding site [chemical binding]; other site 1401659011374 catalytic residue [active] 1401659011375 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1401659011376 Transposase; Region: HTH_Tnp_1; pfam01527 1401659011377 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1401659011378 active site 1401659011379 catalytic residues [active] 1401659011380 DNA binding site [nucleotide binding] 1401659011381 Int/Topo IB signature motif; other site 1401659011382 Transposase; Region: HTH_Tnp_1; cl17663 1401659011383 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1401659011384 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 1401659011385 HTH-like domain; Region: HTH_21; pfam13276 1401659011386 Integrase core domain; Region: rve; pfam00665 1401659011387 Integrase core domain; Region: rve_3; pfam13683 1401659011388 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 1401659011389 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1401659011390 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1401659011391 FAD binding pocket [chemical binding]; other site 1401659011392 FAD binding motif [chemical binding]; other site 1401659011393 phosphate binding motif [ion binding]; other site 1401659011394 NAD binding pocket [chemical binding]; other site 1401659011395 Predicted transcriptional regulators [Transcription]; Region: COG1695 1401659011396 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1401659011397 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1401659011398 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1401659011399 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1401659011400 dimerization interface [polypeptide binding]; other site 1401659011401 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1401659011402 dimer interface [polypeptide binding]; other site 1401659011403 putative CheW interface [polypeptide binding]; other site 1401659011404 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1401659011405 PAS fold; Region: PAS_3; pfam08447 1401659011406 putative active site [active] 1401659011407 heme pocket [chemical binding]; other site 1401659011408 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1401659011409 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1401659011410 dimer interface [polypeptide binding]; other site 1401659011411 putative CheW interface [polypeptide binding]; other site 1401659011412 diguanylate cyclase; Provisional; Region: PRK09894 1401659011413 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1401659011414 metal binding site [ion binding]; metal-binding site 1401659011415 active site 1401659011416 I-site; other site 1401659011417 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 1401659011418 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1401659011419 inhibitor-cofactor binding pocket; inhibition site 1401659011420 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659011421 catalytic residue [active] 1401659011422 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1401659011423 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1401659011424 active site 1401659011425 FMN binding site [chemical binding]; other site 1401659011426 2,4-decadienoyl-CoA binding site; other site 1401659011427 catalytic residue [active] 1401659011428 4Fe-4S cluster binding site [ion binding]; other site 1401659011429 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1401659011430 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1401659011431 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 1401659011432 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1401659011433 S-adenosylmethionine binding site [chemical binding]; other site 1401659011434 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 1401659011435 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1401659011436 putative active site [active] 1401659011437 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1401659011438 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1401659011439 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1401659011440 serine/threonine transporter SstT; Provisional; Region: PRK13628 1401659011441 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1401659011442 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 1401659011443 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1401659011444 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1401659011445 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1401659011446 Glucuronate isomerase; Region: UxaC; pfam02614 1401659011447 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1401659011448 D-galactonate transporter; Region: 2A0114; TIGR00893 1401659011449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659011450 putative substrate translocation pore; other site 1401659011451 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 1401659011452 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1401659011453 DNA-binding site [nucleotide binding]; DNA binding site 1401659011454 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1401659011455 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1401659011456 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1401659011457 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 1401659011458 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 1401659011459 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 1401659011460 Predicted membrane protein [Function unknown]; Region: COG5393 1401659011461 YqjK-like protein; Region: YqjK; pfam13997 1401659011462 Predicted membrane protein [Function unknown]; Region: COG2259 1401659011463 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1401659011464 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1401659011465 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1401659011466 putative dimer interface [polypeptide binding]; other site 1401659011467 N-terminal domain interface [polypeptide binding]; other site 1401659011468 putative substrate binding pocket (H-site) [chemical binding]; other site 1401659011469 Predicted membrane protein [Function unknown]; Region: COG3152 1401659011470 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1401659011471 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1401659011472 putative substrate binding site [chemical binding]; other site 1401659011473 putative ATP binding site [chemical binding]; other site 1401659011474 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1401659011475 trimer interface; other site 1401659011476 sugar binding site [chemical binding]; other site 1401659011477 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1401659011478 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1401659011479 active site turn [active] 1401659011480 phosphorylation site [posttranslational modification] 1401659011481 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1401659011482 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1401659011483 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1401659011484 substrate binding [chemical binding]; other site 1401659011485 active site 1401659011486 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1401659011487 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 1401659011488 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1401659011489 DNA binding site [nucleotide binding] 1401659011490 domain linker motif; other site 1401659011491 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1401659011492 dimerization interface [polypeptide binding]; other site 1401659011493 ligand binding site [chemical binding]; other site 1401659011494 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659011495 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1401659011496 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1401659011497 dimerization interface [polypeptide binding]; other site 1401659011498 Pirin-related protein [General function prediction only]; Region: COG1741 1401659011499 Pirin; Region: Pirin; pfam02678 1401659011500 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 1401659011501 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 1401659011502 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1401659011503 putative SAM binding site [chemical binding]; other site 1401659011504 putative homodimer interface [polypeptide binding]; other site 1401659011505 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 1401659011506 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1401659011507 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1401659011508 putative ligand binding site [chemical binding]; other site 1401659011509 TIGR00252 family protein; Region: TIGR00252 1401659011510 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1401659011511 dimer interface [polypeptide binding]; other site 1401659011512 active site 1401659011513 outer membrane lipoprotein; Provisional; Region: PRK11023 1401659011514 BON domain; Region: BON; pfam04972 1401659011515 BON domain; Region: BON; pfam04972 1401659011516 Predicted permease; Region: DUF318; pfam03773 1401659011517 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 1401659011518 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1401659011519 NAD binding site [chemical binding]; other site 1401659011520 active site 1401659011521 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1401659011522 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1401659011523 proposed catalytic triad [active] 1401659011524 conserved cys residue [active] 1401659011525 hypothetical protein; Provisional; Region: PRK03467 1401659011526 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1401659011527 GIY-YIG motif/motif A; other site 1401659011528 putative active site [active] 1401659011529 putative metal binding site [ion binding]; other site 1401659011530 putative acetyltransferase; Provisional; Region: PRK03624 1401659011531 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1401659011532 Coenzyme A binding pocket [chemical binding]; other site 1401659011533 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 1401659011534 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1401659011535 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1401659011536 Peptidase family U32; Region: Peptidase_U32; pfam01136 1401659011537 putative protease; Provisional; Region: PRK15447 1401659011538 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1401659011539 hypothetical protein; Provisional; Region: PRK10508 1401659011540 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1401659011541 tryptophan permease; Provisional; Region: PRK10483 1401659011542 aromatic amino acid transport protein; Region: araaP; TIGR00837 1401659011543 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1401659011544 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1401659011545 ATP binding site [chemical binding]; other site 1401659011546 Mg++ binding site [ion binding]; other site 1401659011547 motif III; other site 1401659011548 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1401659011549 nucleotide binding region [chemical binding]; other site 1401659011550 ATP-binding site [chemical binding]; other site 1401659011551 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1401659011552 putative RNA binding site [nucleotide binding]; other site 1401659011553 TPR repeat; Region: TPR_11; pfam13414 1401659011554 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1401659011555 binding surface 1401659011556 TPR motif; other site 1401659011557 TPR repeat; Region: TPR_11; pfam13414 1401659011558 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1401659011559 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1401659011560 trimer interface [polypeptide binding]; other site 1401659011561 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1401659011562 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1401659011563 RNase E interface [polypeptide binding]; other site 1401659011564 trimer interface [polypeptide binding]; other site 1401659011565 active site 1401659011566 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1401659011567 putative nucleic acid binding region [nucleotide binding]; other site 1401659011568 G-X-X-G motif; other site 1401659011569 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1401659011570 RNA binding site [nucleotide binding]; other site 1401659011571 domain interface; other site 1401659011572 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1401659011573 16S/18S rRNA binding site [nucleotide binding]; other site 1401659011574 S13e-L30e interaction site [polypeptide binding]; other site 1401659011575 25S rRNA binding site [nucleotide binding]; other site 1401659011576 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1401659011577 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1401659011578 RNA binding site [nucleotide binding]; other site 1401659011579 active site 1401659011580 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1401659011581 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1401659011582 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1401659011583 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1401659011584 translation initiation factor IF-2; Region: IF-2; TIGR00487 1401659011585 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1401659011586 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1401659011587 G1 box; other site 1401659011588 putative GEF interaction site [polypeptide binding]; other site 1401659011589 GTP/Mg2+ binding site [chemical binding]; other site 1401659011590 Switch I region; other site 1401659011591 G2 box; other site 1401659011592 G3 box; other site 1401659011593 Switch II region; other site 1401659011594 G4 box; other site 1401659011595 G5 box; other site 1401659011596 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1401659011597 Translation-initiation factor 2; Region: IF-2; pfam11987 1401659011598 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1401659011599 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1401659011600 NusA N-terminal domain; Region: NusA_N; pfam08529 1401659011601 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1401659011602 RNA binding site [nucleotide binding]; other site 1401659011603 homodimer interface [polypeptide binding]; other site 1401659011604 NusA-like KH domain; Region: KH_5; pfam13184 1401659011605 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1401659011606 G-X-X-G motif; other site 1401659011607 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1401659011608 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1401659011609 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1401659011610 hypothetical protein; Provisional; Region: PRK14641 1401659011611 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1401659011612 putative oligomer interface [polypeptide binding]; other site 1401659011613 putative RNA binding site [nucleotide binding]; other site 1401659011614 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1401659011615 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1401659011616 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1401659011617 active site 1401659011618 substrate binding site [chemical binding]; other site 1401659011619 metal binding site [ion binding]; metal-binding site 1401659011620 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1401659011621 dihydropteroate synthase; Region: DHPS; TIGR01496 1401659011622 substrate binding pocket [chemical binding]; other site 1401659011623 dimer interface [polypeptide binding]; other site 1401659011624 inhibitor binding site; inhibition site 1401659011625 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 1401659011626 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1401659011627 Walker A motif; other site 1401659011628 ATP binding site [chemical binding]; other site 1401659011629 Walker B motif; other site 1401659011630 arginine finger; other site 1401659011631 Peptidase family M41; Region: Peptidase_M41; pfam01434 1401659011632 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1401659011633 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1401659011634 S-adenosylmethionine binding site [chemical binding]; other site 1401659011635 RNA-binding protein YhbY; Provisional; Region: PRK10343 1401659011636 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1401659011637 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1401659011638 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1401659011639 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 1401659011640 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1401659011641 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1401659011642 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1401659011643 active site 1401659011644 phosphorylation site [posttranslational modification] 1401659011645 intermolecular recognition site; other site 1401659011646 dimerization interface [polypeptide binding]; other site 1401659011647 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1401659011648 DNA binding site [nucleotide binding] 1401659011649 sensor protein BasS/PmrB; Provisional; Region: PRK10755 1401659011650 HAMP domain; Region: HAMP; pfam00672 1401659011651 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1401659011652 dimer interface [polypeptide binding]; other site 1401659011653 phosphorylation site [posttranslational modification] 1401659011654 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1401659011655 ATP binding site [chemical binding]; other site 1401659011656 Mg2+ binding site [ion binding]; other site 1401659011657 G-X-G motif; other site 1401659011658 GTPase CgtA; Reviewed; Region: obgE; PRK12298 1401659011659 GTP1/OBG; Region: GTP1_OBG; pfam01018 1401659011660 Obg GTPase; Region: Obg; cd01898 1401659011661 G1 box; other site 1401659011662 GTP/Mg2+ binding site [chemical binding]; other site 1401659011663 Switch I region; other site 1401659011664 G2 box; other site 1401659011665 G3 box; other site 1401659011666 Switch II region; other site 1401659011667 G4 box; other site 1401659011668 G5 box; other site 1401659011669 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1401659011670 EamA-like transporter family; Region: EamA; pfam00892 1401659011671 EamA-like transporter family; Region: EamA; pfam00892 1401659011672 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1401659011673 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1401659011674 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1401659011675 substrate binding pocket [chemical binding]; other site 1401659011676 chain length determination region; other site 1401659011677 substrate-Mg2+ binding site; other site 1401659011678 catalytic residues [active] 1401659011679 aspartate-rich region 1; other site 1401659011680 active site lid residues [active] 1401659011681 aspartate-rich region 2; other site 1401659011682 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 1401659011683 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1401659011684 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1401659011685 hinge; other site 1401659011686 active site 1401659011687 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 1401659011688 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1401659011689 anti sigma factor interaction site; other site 1401659011690 regulatory phosphorylation site [posttranslational modification]; other site 1401659011691 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 1401659011692 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1401659011693 mce related protein; Region: MCE; pfam02470 1401659011694 conserved hypothetical integral membrane protein; Region: TIGR00056 1401659011695 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1401659011696 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 1401659011697 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1401659011698 Walker A/P-loop; other site 1401659011699 ATP binding site [chemical binding]; other site 1401659011700 Q-loop/lid; other site 1401659011701 ABC transporter signature motif; other site 1401659011702 Walker B; other site 1401659011703 D-loop; other site 1401659011704 H-loop/switch region; other site 1401659011705 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 1401659011706 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1401659011707 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1401659011708 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1401659011709 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1401659011710 putative active site [active] 1401659011711 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1401659011712 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 1401659011713 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1401659011714 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 1401659011715 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1401659011716 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 1401659011717 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 1401659011718 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 1401659011719 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1401659011720 Walker A/P-loop; other site 1401659011721 ATP binding site [chemical binding]; other site 1401659011722 Q-loop/lid; other site 1401659011723 ABC transporter signature motif; other site 1401659011724 Walker B; other site 1401659011725 D-loop; other site 1401659011726 H-loop/switch region; other site 1401659011727 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1401659011728 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1401659011729 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1401659011730 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1401659011731 30S subunit binding site; other site 1401659011732 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1401659011733 active site 1401659011734 phosphorylation site [posttranslational modification] 1401659011735 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 1401659011736 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1401659011737 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1401659011738 dimerization domain swap beta strand [polypeptide binding]; other site 1401659011739 regulatory protein interface [polypeptide binding]; other site 1401659011740 active site 1401659011741 regulatory phosphorylation site [posttranslational modification]; other site 1401659011742 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1401659011743 Transglycosylase; Region: Transgly; cl17702 1401659011744 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 1401659011745 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 1401659011746 conserved cys residue [active] 1401659011747 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 1401659011748 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1401659011749 putative active site [active] 1401659011750 heme pocket [chemical binding]; other site 1401659011751 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1401659011752 dimer interface [polypeptide binding]; other site 1401659011753 phosphorylation site [posttranslational modification] 1401659011754 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1401659011755 ATP binding site [chemical binding]; other site 1401659011756 Mg2+ binding site [ion binding]; other site 1401659011757 G-X-G motif; other site 1401659011758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1401659011759 active site 1401659011760 phosphorylation site [posttranslational modification] 1401659011761 intermolecular recognition site; other site 1401659011762 dimerization interface [polypeptide binding]; other site 1401659011763 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1401659011764 putative binding surface; other site 1401659011765 active site 1401659011766 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1401659011767 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1401659011768 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1401659011769 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1401659011770 active site 1401659011771 dimer interface [polypeptide binding]; other site 1401659011772 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1401659011773 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1401659011774 active site 1401659011775 FMN binding site [chemical binding]; other site 1401659011776 substrate binding site [chemical binding]; other site 1401659011777 3Fe-4S cluster binding site [ion binding]; other site 1401659011778 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1401659011779 domain interface; other site 1401659011780 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 1401659011781 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1401659011782 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1401659011783 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1401659011784 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1401659011785 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1401659011786 Autotransporter beta-domain; Region: Autotransporter; smart00869 1401659011787 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 1401659011788 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1401659011789 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 1401659011790 C-terminal domain interface [polypeptide binding]; other site 1401659011791 putative GSH binding site (G-site) [chemical binding]; other site 1401659011792 dimer interface [polypeptide binding]; other site 1401659011793 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1401659011794 dimer interface [polypeptide binding]; other site 1401659011795 N-terminal domain interface [polypeptide binding]; other site 1401659011796 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1401659011797 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1401659011798 23S rRNA interface [nucleotide binding]; other site 1401659011799 L3 interface [polypeptide binding]; other site 1401659011800 Predicted ATPase [General function prediction only]; Region: COG1485 1401659011801 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 1401659011802 hypothetical protein; Provisional; Region: PRK11677 1401659011803 serine endoprotease; Provisional; Region: PRK10139 1401659011804 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1401659011805 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1401659011806 protein binding site [polypeptide binding]; other site 1401659011807 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1401659011808 serine endoprotease; Provisional; Region: PRK10898 1401659011809 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1401659011810 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1401659011811 protein binding site [polypeptide binding]; other site 1401659011812 malate dehydrogenase; Provisional; Region: PRK05086 1401659011813 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 1401659011814 NAD binding site [chemical binding]; other site 1401659011815 dimerization interface [polypeptide binding]; other site 1401659011816 Substrate binding site [chemical binding]; other site 1401659011817 arginine repressor; Provisional; Region: PRK05066 1401659011818 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1401659011819 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1401659011820 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1401659011821 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1401659011822 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1401659011823 RNAase interaction site [polypeptide binding]; other site 1401659011824 succinic semialdehyde dehydrogenase; Region: PLN02278 1401659011825 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1401659011826 tetramerization interface [polypeptide binding]; other site 1401659011827 NAD(P) binding site [chemical binding]; other site 1401659011828 catalytic residues [active] 1401659011829 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 1401659011830 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1401659011831 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 1401659011832 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1401659011833 HlyD family secretion protein; Region: HlyD_3; pfam13437 1401659011834 efflux system membrane protein; Provisional; Region: PRK11594 1401659011835 transcriptional regulator; Provisional; Region: PRK10632 1401659011836 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659011837 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1401659011838 putative effector binding pocket; other site 1401659011839 dimerization interface [polypeptide binding]; other site 1401659011840 protease TldD; Provisional; Region: tldD; PRK10735 1401659011841 hypothetical protein; Provisional; Region: PRK10899 1401659011842 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1401659011843 ribonuclease G; Provisional; Region: PRK11712 1401659011844 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1401659011845 homodimer interface [polypeptide binding]; other site 1401659011846 oligonucleotide binding site [chemical binding]; other site 1401659011847 Maf-like protein; Region: Maf; pfam02545 1401659011848 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1401659011849 active site 1401659011850 dimer interface [polypeptide binding]; other site 1401659011851 rod shape-determining protein MreD; Provisional; Region: PRK11060 1401659011852 rod shape-determining protein MreC; Region: mreC; TIGR00219 1401659011853 rod shape-determining protein MreC; Region: MreC; pfam04085 1401659011854 rod shape-determining protein MreB; Provisional; Region: PRK13927 1401659011855 MreB and similar proteins; Region: MreB_like; cd10225 1401659011856 nucleotide binding site [chemical binding]; other site 1401659011857 Mg binding site [ion binding]; other site 1401659011858 putative protofilament interaction site [polypeptide binding]; other site 1401659011859 RodZ interaction site [polypeptide binding]; other site 1401659011860 regulatory protein CsrD; Provisional; Region: PRK11059 1401659011861 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1401659011862 metal binding site [ion binding]; metal-binding site 1401659011863 active site 1401659011864 I-site; other site 1401659011865 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1401659011866 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1401659011867 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1401659011868 NADP binding site [chemical binding]; other site 1401659011869 dimer interface [polypeptide binding]; other site 1401659011870 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1401659011871 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 1401659011872 Moco binding site; other site 1401659011873 metal coordination site [ion binding]; other site 1401659011874 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1401659011875 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1401659011876 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1401659011877 active site 1401659011878 trimer interface [polypeptide binding]; other site 1401659011879 dimer interface [polypeptide binding]; other site 1401659011880 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1401659011881 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1401659011882 carboxyltransferase (CT) interaction site; other site 1401659011883 biotinylation site [posttranslational modification]; other site 1401659011884 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1401659011885 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1401659011886 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1401659011887 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1401659011888 Protein of unknown function (DUF997); Region: DUF997; cl01614 1401659011889 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 1401659011890 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1401659011891 Na binding site [ion binding]; other site 1401659011892 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1401659011893 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1401659011894 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 1401659011895 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 1401659011896 active site 1401659011897 zinc binding site [ion binding]; other site 1401659011898 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 1401659011899 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1401659011900 FMN binding site [chemical binding]; other site 1401659011901 active site 1401659011902 catalytic residues [active] 1401659011903 substrate binding site [chemical binding]; other site 1401659011904 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 1401659011905 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 1401659011906 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1401659011907 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1401659011908 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1401659011909 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1401659011910 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1401659011911 metal binding site [ion binding]; metal-binding site 1401659011912 active site 1401659011913 I-site; other site 1401659011914 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1401659011915 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 1401659011916 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1401659011917 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1401659011918 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 1401659011919 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1401659011920 HlyD family secretion protein; Region: HlyD_3; pfam13437 1401659011921 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 1401659011922 Protein export membrane protein; Region: SecD_SecF; cl14618 1401659011923 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1401659011924 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1401659011925 substrate binding pocket [chemical binding]; other site 1401659011926 membrane-bound complex binding site; other site 1401659011927 hinge residues; other site 1401659011928 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 1401659011929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659011930 conserved gate region; other site 1401659011931 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659011932 putative PBP binding loops; other site 1401659011933 dimer interface [polypeptide binding]; other site 1401659011934 ABC-ATPase subunit interface; other site 1401659011935 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659011936 dimer interface [polypeptide binding]; other site 1401659011937 conserved gate region; other site 1401659011938 putative PBP binding loops; other site 1401659011939 ABC-ATPase subunit interface; other site 1401659011940 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1401659011941 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1401659011942 Walker A/P-loop; other site 1401659011943 ATP binding site [chemical binding]; other site 1401659011944 Q-loop/lid; other site 1401659011945 ABC transporter signature motif; other site 1401659011946 Walker B; other site 1401659011947 D-loop; other site 1401659011948 H-loop/switch region; other site 1401659011949 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1401659011950 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1401659011951 purine monophosphate binding site [chemical binding]; other site 1401659011952 dimer interface [polypeptide binding]; other site 1401659011953 putative catalytic residues [active] 1401659011954 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1401659011955 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1401659011956 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1401659011957 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1401659011958 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1401659011959 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1401659011960 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 1401659011961 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1401659011962 IHF dimer interface [polypeptide binding]; other site 1401659011963 IHF - DNA interface [nucleotide binding]; other site 1401659011964 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 1401659011965 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1401659011966 Active_site [active] 1401659011967 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1401659011968 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1401659011969 substrate binding site [chemical binding]; other site 1401659011970 active site 1401659011971 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1401659011972 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1401659011973 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1401659011974 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1401659011975 putative NADH binding site [chemical binding]; other site 1401659011976 putative active site [active] 1401659011977 nudix motif; other site 1401659011978 putative metal binding site [ion binding]; other site 1401659011979 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 1401659011980 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1401659011981 ThiC-associated domain; Region: ThiC-associated; pfam13667 1401659011982 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1401659011983 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1401659011984 thiamine phosphate binding site [chemical binding]; other site 1401659011985 active site 1401659011986 pyrophosphate binding site [ion binding]; other site 1401659011987 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1401659011988 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1401659011989 ATP binding site [chemical binding]; other site 1401659011990 substrate interface [chemical binding]; other site 1401659011991 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1401659011992 thiS-thiF/thiG interaction site; other site 1401659011993 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1401659011994 ThiS interaction site; other site 1401659011995 putative active site [active] 1401659011996 tetramer interface [polypeptide binding]; other site 1401659011997 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 1401659011998 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1401659011999 FeS/SAM binding site; other site 1401659012000 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1401659012001 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1401659012002 active site 1401659012003 P-loop; other site 1401659012004 phosphorylation site [posttranslational modification] 1401659012005 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1401659012006 methionine cluster; other site 1401659012007 active site 1401659012008 phosphorylation site [posttranslational modification] 1401659012009 metal binding site [ion binding]; metal-binding site 1401659012010 Helix-turn-helix domain; Region: HTH_18; pfam12833 1401659012011 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1401659012012 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1401659012013 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1401659012014 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1401659012015 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1401659012016 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1401659012017 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1401659012018 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1401659012019 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1401659012020 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1401659012021 DNA binding site [nucleotide binding] 1401659012022 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1401659012023 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1401659012024 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1401659012025 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1401659012026 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1401659012027 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1401659012028 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1401659012029 RPB3 interaction site [polypeptide binding]; other site 1401659012030 RPB1 interaction site [polypeptide binding]; other site 1401659012031 RPB11 interaction site [polypeptide binding]; other site 1401659012032 RPB10 interaction site [polypeptide binding]; other site 1401659012033 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1401659012034 L11 interface [polypeptide binding]; other site 1401659012035 putative EF-Tu interaction site [polypeptide binding]; other site 1401659012036 putative EF-G interaction site [polypeptide binding]; other site 1401659012037 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1401659012038 23S rRNA interface [nucleotide binding]; other site 1401659012039 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1401659012040 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1401659012041 mRNA/rRNA interface [nucleotide binding]; other site 1401659012042 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1401659012043 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1401659012044 L7/L12 interface [polypeptide binding]; other site 1401659012045 23S rRNA interface [nucleotide binding]; other site 1401659012046 L25 interface [polypeptide binding]; other site 1401659012047 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1401659012048 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1401659012049 putative homodimer interface [polypeptide binding]; other site 1401659012050 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1401659012051 heterodimer interface [polypeptide binding]; other site 1401659012052 homodimer interface [polypeptide binding]; other site 1401659012053 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1401659012054 elongation factor Tu; Reviewed; Region: PRK00049 1401659012055 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1401659012056 G1 box; other site 1401659012057 GEF interaction site [polypeptide binding]; other site 1401659012058 GTP/Mg2+ binding site [chemical binding]; other site 1401659012059 Switch I region; other site 1401659012060 G2 box; other site 1401659012061 G3 box; other site 1401659012062 Switch II region; other site 1401659012063 G4 box; other site 1401659012064 G5 box; other site 1401659012065 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1401659012066 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1401659012067 Antibiotic Binding Site [chemical binding]; other site 1401659012068 pantothenate kinase; Provisional; Region: PRK05439 1401659012069 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1401659012070 ATP-binding site [chemical binding]; other site 1401659012071 CoA-binding site [chemical binding]; other site 1401659012072 Mg2+-binding site [ion binding]; other site 1401659012073 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1401659012074 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1401659012075 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1401659012076 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1401659012077 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1401659012078 FAD binding domain; Region: FAD_binding_4; pfam01565 1401659012079 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1401659012080 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 1401659012081 potassium transporter; Provisional; Region: PRK10750 1401659012082 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1401659012083 hypothetical protein; Provisional; Region: PRK11568 1401659012084 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1401659012085 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1401659012086 proline dipeptidase; Provisional; Region: PRK13607 1401659012087 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1401659012088 active site 1401659012089 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1401659012090 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1401659012091 substrate binding site [chemical binding]; other site 1401659012092 oxyanion hole (OAH) forming residues; other site 1401659012093 trimer interface [polypeptide binding]; other site 1401659012094 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1401659012095 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1401659012096 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1401659012097 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 1401659012098 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1401659012099 dimer interface [polypeptide binding]; other site 1401659012100 active site 1401659012101 FMN reductase; Validated; Region: fre; PRK08051 1401659012102 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1401659012103 FAD binding pocket [chemical binding]; other site 1401659012104 FAD binding motif [chemical binding]; other site 1401659012105 phosphate binding motif [ion binding]; other site 1401659012106 beta-alpha-beta structure motif; other site 1401659012107 NAD binding pocket [chemical binding]; other site 1401659012108 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 1401659012109 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 1401659012110 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 1401659012111 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1401659012112 active site 1401659012113 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 1401659012114 sec-independent translocase; Provisional; Region: PRK01770 1401659012115 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1401659012116 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 1401659012117 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1401659012118 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 1401659012119 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1401659012120 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1401659012121 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1401659012122 S-adenosylmethionine binding site [chemical binding]; other site 1401659012123 DNA recombination protein RmuC; Provisional; Region: PRK10361 1401659012124 RmuC family; Region: RmuC; pfam02646 1401659012125 uridine phosphorylase; Provisional; Region: PRK11178 1401659012126 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 1401659012127 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1401659012128 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1401659012129 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1401659012130 THF binding site; other site 1401659012131 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1401659012132 substrate binding site [chemical binding]; other site 1401659012133 THF binding site; other site 1401659012134 zinc-binding site [ion binding]; other site 1401659012135 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 1401659012136 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659012137 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 1401659012138 putative dimerization interface [polypeptide binding]; other site 1401659012139 putative hydrolase; Provisional; Region: PRK10976 1401659012140 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1401659012141 active site 1401659012142 motif I; other site 1401659012143 motif II; other site 1401659012144 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1401659012145 lysophospholipase L2; Provisional; Region: PRK10749 1401659012146 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1401659012147 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 1401659012148 threonine efflux system; Provisional; Region: PRK10229 1401659012149 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 1401659012150 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1401659012151 ATP binding site [chemical binding]; other site 1401659012152 putative Mg++ binding site [ion binding]; other site 1401659012153 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1401659012154 nucleotide binding region [chemical binding]; other site 1401659012155 ATP-binding site [chemical binding]; other site 1401659012156 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1401659012157 HRDC domain; Region: HRDC; pfam00570 1401659012158 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 1401659012159 dimerization interface [polypeptide binding]; other site 1401659012160 substrate binding site [chemical binding]; other site 1401659012161 active site 1401659012162 calcium binding site [ion binding]; other site 1401659012163 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1401659012164 CoenzymeA binding site [chemical binding]; other site 1401659012165 subunit interaction site [polypeptide binding]; other site 1401659012166 PHB binding site; other site 1401659012167 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 1401659012168 EamA-like transporter family; Region: EamA; cl17759 1401659012169 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 1401659012170 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1401659012171 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 1401659012172 Cl binding site [ion binding]; other site 1401659012173 oligomer interface [polypeptide binding]; other site 1401659012174 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1401659012175 Part of AAA domain; Region: AAA_19; pfam13245 1401659012176 Family description; Region: UvrD_C_2; pfam13538 1401659012177 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 1401659012178 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1401659012179 motif II; other site 1401659012180 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 1401659012181 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1401659012182 active site 1401659012183 Int/Topo IB signature motif; other site 1401659012184 hypothetical protein; Provisional; Region: PRK10963 1401659012185 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1401659012186 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1401659012187 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1401659012188 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 1401659012189 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 1401659012190 putative iron binding site [ion binding]; other site 1401659012191 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 1401659012192 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 1401659012193 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 1401659012194 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1401659012195 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1401659012196 domain interfaces; other site 1401659012197 active site 1401659012198 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1401659012199 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1401659012200 active site 1401659012201 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1401659012202 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 1401659012203 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 1401659012204 HemY protein N-terminus; Region: HemY_N; pfam07219 1401659012205 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1401659012206 TPR motif; other site 1401659012207 binding surface 1401659012208 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1401659012209 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1401659012210 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1401659012211 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1401659012212 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1401659012213 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1401659012214 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1401659012215 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1401659012216 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1401659012217 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1401659012218 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1401659012219 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1401659012220 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1401659012221 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1401659012222 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1401659012223 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1401659012224 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1401659012225 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1401659012226 putative transport protein YifK; Provisional; Region: PRK10746 1401659012227 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1401659012228 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1401659012229 putative common antigen polymerase; Provisional; Region: PRK02975 1401659012230 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 1401659012231 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 1401659012232 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1401659012233 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1401659012234 inhibitor-cofactor binding pocket; inhibition site 1401659012235 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659012236 catalytic residue [active] 1401659012237 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 1401659012238 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1401659012239 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1401659012240 substrate binding site; other site 1401659012241 tetramer interface; other site 1401659012242 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 1401659012243 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1401659012244 NAD binding site [chemical binding]; other site 1401659012245 substrate binding site [chemical binding]; other site 1401659012246 homodimer interface [polypeptide binding]; other site 1401659012247 active site 1401659012248 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 1401659012249 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1401659012250 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1401659012251 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1401659012252 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1401659012253 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1401659012254 homodimer interface [polypeptide binding]; other site 1401659012255 active site 1401659012256 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 1401659012257 Chain length determinant protein; Region: Wzz; pfam02706 1401659012258 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 1401659012259 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1401659012260 Mg++ binding site [ion binding]; other site 1401659012261 putative catalytic motif [active] 1401659012262 substrate binding site [chemical binding]; other site 1401659012263 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1401659012264 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1401659012265 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1401659012266 RNA binding site [nucleotide binding]; other site 1401659012267 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1401659012268 multimer interface [polypeptide binding]; other site 1401659012269 Walker A motif; other site 1401659012270 ATP binding site [chemical binding]; other site 1401659012271 Walker B motif; other site 1401659012272 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1401659012273 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1401659012274 catalytic residues [active] 1401659012275 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 1401659012276 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1401659012277 ATP binding site [chemical binding]; other site 1401659012278 Mg++ binding site [ion binding]; other site 1401659012279 motif III; other site 1401659012280 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1401659012281 nucleotide binding region [chemical binding]; other site 1401659012282 ATP-binding site [chemical binding]; other site 1401659012283 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 1401659012284 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1401659012285 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 1401659012286 Part of AAA domain; Region: AAA_19; pfam13245 1401659012287 Family description; Region: UvrD_C_2; pfam13538 1401659012288 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 1401659012289 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1401659012290 ketol-acid reductoisomerase; Validated; Region: PRK05225 1401659012291 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1401659012292 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1401659012293 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1401659012294 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659012295 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 1401659012296 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 1401659012297 putative dimerization interface [polypeptide binding]; other site 1401659012298 threonine dehydratase; Reviewed; Region: PRK09224 1401659012299 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1401659012300 tetramer interface [polypeptide binding]; other site 1401659012301 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659012302 catalytic residue [active] 1401659012303 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1401659012304 putative Ile/Val binding site [chemical binding]; other site 1401659012305 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1401659012306 putative Ile/Val binding site [chemical binding]; other site 1401659012307 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1401659012308 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1401659012309 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1401659012310 homodimer interface [polypeptide binding]; other site 1401659012311 substrate-cofactor binding pocket; other site 1401659012312 catalytic residue [active] 1401659012313 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 1401659012314 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 1401659012315 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1401659012316 PYR/PP interface [polypeptide binding]; other site 1401659012317 dimer interface [polypeptide binding]; other site 1401659012318 TPP binding site [chemical binding]; other site 1401659012319 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1401659012320 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1401659012321 TPP-binding site [chemical binding]; other site 1401659012322 dimer interface [polypeptide binding]; other site 1401659012323 putative ATP-dependent protease; Provisional; Region: PRK09862 1401659012324 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1401659012325 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1401659012326 Walker A motif; other site 1401659012327 ATP binding site [chemical binding]; other site 1401659012328 Walker B motif; other site 1401659012329 arginine finger; other site 1401659012330 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1401659012331 hypothetical protein; Provisional; Region: PRK11027 1401659012332 transcriptional regulator HdfR; Provisional; Region: PRK03601 1401659012333 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659012334 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1401659012335 dimerization interface [polypeptide binding]; other site 1401659012336 glutamate racemase; Provisional; Region: PRK00865 1401659012337 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 1401659012338 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1401659012339 N-terminal plug; other site 1401659012340 ligand-binding site [chemical binding]; other site 1401659012341 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 1401659012342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1401659012343 S-adenosylmethionine binding site [chemical binding]; other site 1401659012344 hypothetical protein; Provisional; Region: PRK11056 1401659012345 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1401659012346 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1401659012347 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1401659012348 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1401659012349 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1401659012350 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1401659012351 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659012352 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1401659012353 dimerization interface [polypeptide binding]; other site 1401659012354 argininosuccinate lyase; Provisional; Region: PRK04833 1401659012355 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1401659012356 active sites [active] 1401659012357 tetramer interface [polypeptide binding]; other site 1401659012358 argininosuccinate synthase; Provisional; Region: PRK13820 1401659012359 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1401659012360 ANP binding site [chemical binding]; other site 1401659012361 Substrate Binding Site II [chemical binding]; other site 1401659012362 Substrate Binding Site I [chemical binding]; other site 1401659012363 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 1401659012364 nucleotide binding site [chemical binding]; other site 1401659012365 N-acetyl-L-glutamate binding site [chemical binding]; other site 1401659012366 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1401659012367 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1401659012368 acetylornithine deacetylase; Provisional; Region: PRK05111 1401659012369 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1401659012370 metal binding site [ion binding]; metal-binding site 1401659012371 putative dimer interface [polypeptide binding]; other site 1401659012372 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1401659012373 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1401659012374 putative major fimbrial protein SthE; Provisional; Region: PRK15292 1401659012375 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1401659012376 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1401659012377 PapC N-terminal domain; Region: PapC_N; pfam13954 1401659012378 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1401659012379 PapC C-terminal domain; Region: PapC_C; pfam13953 1401659012380 putative chaperone protein EcpD; Provisional; Region: PRK09926 1401659012381 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1401659012382 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1401659012383 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1401659012384 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 1401659012385 modulator of post-segregation killing protein; Provisional; Region: PRK13720 1401659012386 Predicted transcriptional regulator [Transcription]; Region: COG2944 1401659012387 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1401659012388 salt bridge; other site 1401659012389 non-specific DNA binding site [nucleotide binding]; other site 1401659012390 sequence-specific DNA binding site [nucleotide binding]; other site 1401659012391 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1401659012392 DALR anticodon binding domain; Region: DALR_1; pfam05746 1401659012393 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1401659012394 dimer interface [polypeptide binding]; other site 1401659012395 motif 1; other site 1401659012396 active site 1401659012397 motif 2; other site 1401659012398 motif 3; other site 1401659012399 YsaB-like lipoprotein; Region: YsaB; pfam13983 1401659012400 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1401659012401 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1401659012402 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1401659012403 conserved cys residue [active] 1401659012404 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1401659012405 Isochorismatase family; Region: Isochorismatase; pfam00857 1401659012406 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1401659012407 catalytic triad [active] 1401659012408 conserved cis-peptide bond; other site 1401659012409 xylulokinase; Provisional; Region: PRK15027 1401659012410 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1401659012411 N- and C-terminal domain interface [polypeptide binding]; other site 1401659012412 active site 1401659012413 MgATP binding site [chemical binding]; other site 1401659012414 catalytic site [active] 1401659012415 metal binding site [ion binding]; metal-binding site 1401659012416 xylulose binding site [chemical binding]; other site 1401659012417 homodimer interface [polypeptide binding]; other site 1401659012418 xylose isomerase; Provisional; Region: PRK05474 1401659012419 xylose isomerase; Region: xylose_isom_A; TIGR02630 1401659012420 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 1401659012421 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1401659012422 putative ligand binding site [chemical binding]; other site 1401659012423 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 1401659012424 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1401659012425 Walker A/P-loop; other site 1401659012426 ATP binding site [chemical binding]; other site 1401659012427 Q-loop/lid; other site 1401659012428 ABC transporter signature motif; other site 1401659012429 Walker B; other site 1401659012430 D-loop; other site 1401659012431 H-loop/switch region; other site 1401659012432 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1401659012433 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1401659012434 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1401659012435 TM-ABC transporter signature motif; other site 1401659012436 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 1401659012437 putative dimerization interface [polypeptide binding]; other site 1401659012438 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1401659012439 putative ligand binding site [chemical binding]; other site 1401659012440 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1401659012441 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1401659012442 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1401659012443 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 1401659012444 hypothetical protein; Provisional; Region: PRK10356 1401659012445 alpha-amylase; Reviewed; Region: malS; PRK09505 1401659012446 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1401659012447 active site 1401659012448 catalytic site [active] 1401659012449 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 1401659012450 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1401659012451 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659012452 homodimer interface [polypeptide binding]; other site 1401659012453 catalytic residue [active] 1401659012454 putative transporter; Provisional; Region: PRK11462 1401659012455 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1401659012456 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1401659012457 Protein of unknown function (DUF796); Region: DUF796; cl01226 1401659012458 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1401659012459 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1401659012460 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1401659012461 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1401659012462 active site 1401659012463 catalytic tetrad [active] 1401659012464 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1401659012465 Ligand binding site; other site 1401659012466 metal-binding site 1401659012467 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1401659012468 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1401659012469 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1401659012470 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1401659012471 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1401659012472 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1401659012473 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1401659012474 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1401659012475 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1401659012476 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1401659012477 catalytic loop [active] 1401659012478 iron binding site [ion binding]; other site 1401659012479 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1401659012480 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1401659012481 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1401659012482 putative metal binding site; other site 1401659012483 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1401659012484 binding surface 1401659012485 TPR motif; other site 1401659012486 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1401659012487 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659012488 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1401659012489 putative effector binding pocket; other site 1401659012490 putative dimerization interface [polypeptide binding]; other site 1401659012491 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1401659012492 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659012493 putative substrate translocation pore; other site 1401659012494 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1401659012495 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1401659012496 putative NAD(P) binding site [chemical binding]; other site 1401659012497 putative substrate binding site [chemical binding]; other site 1401659012498 catalytic Zn binding site [ion binding]; other site 1401659012499 structural Zn binding site [ion binding]; other site 1401659012500 dimer interface [polypeptide binding]; other site 1401659012501 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1401659012502 CAAX protease self-immunity; Region: Abi; pfam02517 1401659012503 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1401659012504 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1401659012505 dimer interface [polypeptide binding]; other site 1401659012506 phosphorylation site [posttranslational modification] 1401659012507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1401659012508 ATP binding site [chemical binding]; other site 1401659012509 G-X-G motif; other site 1401659012510 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 1401659012511 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1401659012512 active site 1401659012513 phosphorylation site [posttranslational modification] 1401659012514 intermolecular recognition site; other site 1401659012515 dimerization interface [polypeptide binding]; other site 1401659012516 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1401659012517 DNA binding site [nucleotide binding] 1401659012518 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1401659012519 active site 1401659012520 homotetramer interface [polypeptide binding]; other site 1401659012521 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1401659012522 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1401659012523 transmembrane helices; other site 1401659012524 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 1401659012525 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1401659012526 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1401659012527 substrate binding pocket [chemical binding]; other site 1401659012528 membrane-bound complex binding site; other site 1401659012529 hinge residues; other site 1401659012530 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1401659012531 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1401659012532 active site 1401659012533 ADP/pyrophosphate binding site [chemical binding]; other site 1401659012534 dimerization interface [polypeptide binding]; other site 1401659012535 allosteric effector site; other site 1401659012536 fructose-1,6-bisphosphate binding site; other site 1401659012537 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 1401659012538 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1401659012539 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1401659012540 dimer interface [polypeptide binding]; other site 1401659012541 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 1401659012542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1401659012543 active site 1401659012544 intermolecular recognition site; other site 1401659012545 dimerization interface [polypeptide binding]; other site 1401659012546 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1401659012547 DNA binding site [nucleotide binding] 1401659012548 two-component sensor protein; Provisional; Region: cpxA; PRK09470 1401659012549 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1401659012550 dimerization interface [polypeptide binding]; other site 1401659012551 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1401659012552 dimer interface [polypeptide binding]; other site 1401659012553 phosphorylation site [posttranslational modification] 1401659012554 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1401659012555 ATP binding site [chemical binding]; other site 1401659012556 Mg2+ binding site [ion binding]; other site 1401659012557 G-X-G motif; other site 1401659012558 putative rRNA methylase; Provisional; Region: PRK10358 1401659012559 serine acetyltransferase; Provisional; Region: cysE; PRK11132 1401659012560 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 1401659012561 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1401659012562 trimer interface [polypeptide binding]; other site 1401659012563 active site 1401659012564 substrate binding site [chemical binding]; other site 1401659012565 CoA binding site [chemical binding]; other site 1401659012566 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1401659012567 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1401659012568 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1401659012569 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 1401659012570 SecA binding site; other site 1401659012571 Preprotein binding site; other site 1401659012572 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1401659012573 GSH binding site [chemical binding]; other site 1401659012574 catalytic residues [active] 1401659012575 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1401659012576 active site residue [active] 1401659012577 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1401659012578 phosphoglyceromutase; Provisional; Region: PRK05434 1401659012579 AmiB activator; Provisional; Region: PRK11637 1401659012580 Peptidase family M23; Region: Peptidase_M23; pfam01551 1401659012581 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1401659012582 NodB motif; other site 1401659012583 putative active site [active] 1401659012584 putative catalytic site [active] 1401659012585 Zn binding site [ion binding]; other site 1401659012586 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1401659012587 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1401659012588 putative metal binding site; other site 1401659012589 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1401659012590 Sulfatase; Region: Sulfatase; pfam00884 1401659012591 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1401659012592 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1401659012593 NAD(P) binding site [chemical binding]; other site 1401659012594 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1401659012595 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1401659012596 substrate-cofactor binding pocket; other site 1401659012597 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1401659012598 catalytic residue [active] 1401659012599 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 1401659012600 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 1401659012601 NADP binding site [chemical binding]; other site 1401659012602 homopentamer interface [polypeptide binding]; other site 1401659012603 substrate binding site [chemical binding]; other site 1401659012604 active site 1401659012605 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1401659012606 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1401659012607 putative active site [active] 1401659012608 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1401659012609 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1401659012610 putative active site [active] 1401659012611 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1401659012612 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1401659012613 O-Antigen ligase; Region: Wzy_C; pfam04932 1401659012614 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 1401659012615 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1401659012616 putative ADP-binding pocket [chemical binding]; other site 1401659012617 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 1401659012618 putative active site [active] 1401659012619 putative catalytic site [active] 1401659012620 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 1401659012621 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1401659012622 putative active site [active] 1401659012623 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1401659012624 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1401659012625 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1401659012626 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1401659012627 putative ADP-binding pocket [chemical binding]; other site 1401659012628 putative glycosyl transferase; Provisional; Region: PRK10073 1401659012629 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1401659012630 active site 1401659012631 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1401659012632 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1401659012633 putative active site [active] 1401659012634 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1401659012635 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1401659012636 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 1401659012637 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1401659012638 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1401659012639 putative metal binding site; other site 1401659012640 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1401659012641 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1401659012642 active site 1401659012643 (T/H)XGH motif; other site 1401659012644 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1401659012645 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1401659012646 DNA binding site [nucleotide binding] 1401659012647 catalytic residue [active] 1401659012648 H2TH interface [polypeptide binding]; other site 1401659012649 putative catalytic residues [active] 1401659012650 turnover-facilitating residue; other site 1401659012651 intercalation triad [nucleotide binding]; other site 1401659012652 8OG recognition residue [nucleotide binding]; other site 1401659012653 putative reading head residues; other site 1401659012654 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1401659012655 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1401659012656 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1401659012657 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1401659012658 hypothetical protein; Reviewed; Region: PRK00024 1401659012659 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1401659012660 MPN+ (JAMM) motif; other site 1401659012661 Zinc-binding site [ion binding]; other site 1401659012662 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1401659012663 Flavoprotein; Region: Flavoprotein; pfam02441 1401659012664 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1401659012665 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1401659012666 trimer interface [polypeptide binding]; other site 1401659012667 active site 1401659012668 division inhibitor protein; Provisional; Region: slmA; PRK09480 1401659012669 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1401659012670 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1401659012671 active site 1401659012672 ribonuclease PH; Reviewed; Region: rph; PRK00173 1401659012673 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1401659012674 hexamer interface [polypeptide binding]; other site 1401659012675 active site 1401659012676 hypothetical protein; Provisional; Region: PRK11820 1401659012677 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1401659012678 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1401659012679 Predicted membrane protein [Function unknown]; Region: COG2860 1401659012680 UPF0126 domain; Region: UPF0126; pfam03458 1401659012681 UPF0126 domain; Region: UPF0126; pfam03458 1401659012682 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 1401659012683 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 1401659012684 nucleotide binding pocket [chemical binding]; other site 1401659012685 K-X-D-G motif; other site 1401659012686 catalytic site [active] 1401659012687 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1401659012688 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1401659012689 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1401659012690 catalytic site [active] 1401659012691 G-X2-G-X-G-K; other site 1401659012692 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1401659012693 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 1401659012694 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1401659012695 Zn2+ binding site [ion binding]; other site 1401659012696 Mg2+ binding site [ion binding]; other site 1401659012697 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1401659012698 synthetase active site [active] 1401659012699 NTP binding site [chemical binding]; other site 1401659012700 metal binding site [ion binding]; metal-binding site 1401659012701 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1401659012702 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1401659012703 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 1401659012704 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1401659012705 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 1401659012706 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1401659012707 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1401659012708 generic binding surface II; other site 1401659012709 ssDNA binding site; other site 1401659012710 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1401659012711 ATP binding site [chemical binding]; other site 1401659012712 putative Mg++ binding site [ion binding]; other site 1401659012713 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1401659012714 nucleotide binding region [chemical binding]; other site 1401659012715 ATP-binding site [chemical binding]; other site 1401659012716 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1401659012717 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1401659012718 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1401659012719 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1401659012720 PapC N-terminal domain; Region: PapC_N; pfam13954 1401659012721 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1401659012722 PapC C-terminal domain; Region: PapC_C; pfam13953 1401659012723 Fimbrial protein; Region: Fimbrial; pfam00419 1401659012724 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1401659012725 Fimbrial protein; Region: Fimbrial; pfam00419 1401659012726 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1401659012727 Fimbrial protein; Region: Fimbrial; pfam00419 1401659012728 Fimbrial protein; Region: Fimbrial; pfam00419 1401659012729 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1401659012730 AsmA family; Region: AsmA; pfam05170 1401659012731 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1401659012732 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1401659012733 Coenzyme A binding pocket [chemical binding]; other site 1401659012734 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 1401659012735 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1401659012736 putative active site [active] 1401659012737 dimerization interface [polypeptide binding]; other site 1401659012738 putative tRNAtyr binding site [nucleotide binding]; other site 1401659012739 hypothetical protein; Reviewed; Region: PRK01637 1401659012740 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1401659012741 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1401659012742 motif II; other site 1401659012743 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1401659012744 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1401659012745 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1401659012746 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 1401659012747 substrate binding site [chemical binding]; other site 1401659012748 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1401659012749 ATP binding site [chemical binding]; other site 1401659012750 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 1401659012751 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1401659012752 Class I aldolases; Region: Aldolase_Class_I; cl17187 1401659012753 catalytic residue [active] 1401659012754 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 1401659012755 dimerization interface [polypeptide binding]; other site 1401659012756 putative active cleft [active] 1401659012757 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 1401659012758 active site 1401659012759 catalytic residues [active] 1401659012760 alpha-glucosidase; Provisional; Region: PRK10426 1401659012761 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1401659012762 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 1401659012763 putative active site [active] 1401659012764 putative catalytic site [active] 1401659012765 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1401659012766 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1401659012767 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1401659012768 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1401659012769 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1401659012770 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1401659012771 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1401659012772 G1 box; other site 1401659012773 putative GEF interaction site [polypeptide binding]; other site 1401659012774 GTP/Mg2+ binding site [chemical binding]; other site 1401659012775 Switch I region; other site 1401659012776 G2 box; other site 1401659012777 G3 box; other site 1401659012778 Switch II region; other site 1401659012779 G4 box; other site 1401659012780 G5 box; other site 1401659012781 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1401659012782 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1401659012783 glutamine synthetase; Provisional; Region: glnA; PRK09469 1401659012784 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1401659012785 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1401659012786 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 1401659012787 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1401659012788 putative active site [active] 1401659012789 heme pocket [chemical binding]; other site 1401659012790 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1401659012791 dimer interface [polypeptide binding]; other site 1401659012792 phosphorylation site [posttranslational modification] 1401659012793 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1401659012794 ATP binding site [chemical binding]; other site 1401659012795 Mg2+ binding site [ion binding]; other site 1401659012796 G-X-G motif; other site 1401659012797 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 1401659012798 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1401659012799 active site 1401659012800 phosphorylation site [posttranslational modification] 1401659012801 intermolecular recognition site; other site 1401659012802 dimerization interface [polypeptide binding]; other site 1401659012803 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1401659012804 Walker A motif; other site 1401659012805 ATP binding site [chemical binding]; other site 1401659012806 Walker B motif; other site 1401659012807 arginine finger; other site 1401659012808 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1401659012809 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1401659012810 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1401659012811 FeS/SAM binding site; other site 1401659012812 HemN C-terminal domain; Region: HemN_C; pfam06969 1401659012813 Der GTPase activator; Provisional; Region: PRK05244 1401659012814 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1401659012815 G1 box; other site 1401659012816 GTP/Mg2+ binding site [chemical binding]; other site 1401659012817 Switch I region; other site 1401659012818 G2 box; other site 1401659012819 G3 box; other site 1401659012820 Switch II region; other site 1401659012821 G4 box; other site 1401659012822 G5 box; other site 1401659012823 DNA polymerase I; Provisional; Region: PRK05755 1401659012824 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1401659012825 active site 1401659012826 metal binding site 1 [ion binding]; metal-binding site 1401659012827 putative 5' ssDNA interaction site; other site 1401659012828 metal binding site 3; metal-binding site 1401659012829 metal binding site 2 [ion binding]; metal-binding site 1401659012830 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1401659012831 putative DNA binding site [nucleotide binding]; other site 1401659012832 putative metal binding site [ion binding]; other site 1401659012833 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1401659012834 active site 1401659012835 catalytic site [active] 1401659012836 substrate binding site [chemical binding]; other site 1401659012837 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1401659012838 active site 1401659012839 DNA binding site [nucleotide binding] 1401659012840 catalytic site [active] 1401659012841 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1401659012842 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1401659012843 putative acyl-acceptor binding pocket; other site 1401659012844 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1401659012845 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1401659012846 catalytic residues [active] 1401659012847 hinge region; other site 1401659012848 alpha helical domain; other site 1401659012849 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1401659012850 serine/threonine protein kinase; Provisional; Region: PRK11768 1401659012851 Protein of unknown function (DUF1040); Region: DUF1040; cl01176 1401659012852 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1401659012853 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1401659012854 GTP binding site; other site 1401659012855 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1401659012856 Walker A motif; other site 1401659012857 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1401659012858 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1401659012859 DNA-binding site [nucleotide binding]; DNA binding site 1401659012860 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1401659012861 putative transporter; Provisional; Region: PRK10504 1401659012862 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659012863 putative substrate translocation pore; other site 1401659012864 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1401659012865 transcriptional repressor RbsR; Provisional; Region: PRK10423 1401659012866 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1401659012867 DNA binding site [nucleotide binding] 1401659012868 domain linker motif; other site 1401659012869 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1401659012870 dimerization interface [polypeptide binding]; other site 1401659012871 ligand binding site [chemical binding]; other site 1401659012872 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1401659012873 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1401659012874 substrate binding site [chemical binding]; other site 1401659012875 dimer interface [polypeptide binding]; other site 1401659012876 ATP binding site [chemical binding]; other site 1401659012877 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1401659012878 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1401659012879 ligand binding site [chemical binding]; other site 1401659012880 dimerization interface [polypeptide binding]; other site 1401659012881 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1401659012882 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1401659012883 TM-ABC transporter signature motif; other site 1401659012884 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 1401659012885 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1401659012886 Walker A/P-loop; other site 1401659012887 ATP binding site [chemical binding]; other site 1401659012888 Q-loop/lid; other site 1401659012889 ABC transporter signature motif; other site 1401659012890 Walker B; other site 1401659012891 D-loop; other site 1401659012892 H-loop/switch region; other site 1401659012893 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1401659012894 D-ribose pyranase; Provisional; Region: PRK11797 1401659012895 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 1401659012896 potassium uptake protein; Region: kup; TIGR00794 1401659012897 regulatory ATPase RavA; Provisional; Region: PRK13531 1401659012898 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1401659012899 Walker A motif; other site 1401659012900 ATP binding site [chemical binding]; other site 1401659012901 Walker B motif; other site 1401659012902 arginine finger; other site 1401659012903 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 1401659012904 hypothetical protein; Provisional; Region: yieM; PRK10997 1401659012905 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 1401659012906 metal ion-dependent adhesion site (MIDAS); other site 1401659012907 Asparagine synthetase A [Amino acid transport and metabolism]; Region: AsnA; COG2502 1401659012908 motif 1; other site 1401659012909 dimer interface [polypeptide binding]; other site 1401659012910 active site 1401659012911 motif 2; other site 1401659012912 motif 3; other site 1401659012913 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 1401659012914 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1401659012915 putative DNA binding site [nucleotide binding]; other site 1401659012916 putative Zn2+ binding site [ion binding]; other site 1401659012917 AsnC family; Region: AsnC_trans_reg; pfam01037 1401659012918 FMN-binding protein MioC; Provisional; Region: PRK09004 1401659012919 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1401659012920 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1401659012921 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1401659012922 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1401659012923 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1401659012924 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 1401659012925 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1401659012926 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1401659012927 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1401659012928 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1401659012929 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1401659012930 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1401659012931 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1401659012932 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1401659012933 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1401659012934 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1401659012935 beta subunit interaction interface [polypeptide binding]; other site 1401659012936 Walker A motif; other site 1401659012937 ATP binding site [chemical binding]; other site 1401659012938 Walker B motif; other site 1401659012939 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1401659012940 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1401659012941 core domain interface [polypeptide binding]; other site 1401659012942 delta subunit interface [polypeptide binding]; other site 1401659012943 epsilon subunit interface [polypeptide binding]; other site 1401659012944 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1401659012945 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1401659012946 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1401659012947 alpha subunit interaction interface [polypeptide binding]; other site 1401659012948 Walker A motif; other site 1401659012949 ATP binding site [chemical binding]; other site 1401659012950 Walker B motif; other site 1401659012951 inhibitor binding site; inhibition site 1401659012952 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1401659012953 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1401659012954 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1401659012955 gamma subunit interface [polypeptide binding]; other site 1401659012956 epsilon subunit interface [polypeptide binding]; other site 1401659012957 LBP interface [polypeptide binding]; other site 1401659012958 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 1401659012959 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1401659012960 Substrate binding site; other site 1401659012961 Mg++ binding site; other site 1401659012962 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1401659012963 active site 1401659012964 substrate binding site [chemical binding]; other site 1401659012965 CoA binding site [chemical binding]; other site 1401659012966 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1401659012967 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1401659012968 glutaminase active site [active] 1401659012969 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1401659012970 dimer interface [polypeptide binding]; other site 1401659012971 active site 1401659012972 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1401659012973 dimer interface [polypeptide binding]; other site 1401659012974 active site 1401659012975 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 1401659012976 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1401659012977 substrate binding pocket [chemical binding]; other site 1401659012978 membrane-bound complex binding site; other site 1401659012979 hinge residues; other site 1401659012980 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 1401659012981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659012982 dimer interface [polypeptide binding]; other site 1401659012983 conserved gate region; other site 1401659012984 putative PBP binding loops; other site 1401659012985 ABC-ATPase subunit interface; other site 1401659012986 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 1401659012987 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1401659012988 dimer interface [polypeptide binding]; other site 1401659012989 conserved gate region; other site 1401659012990 putative PBP binding loops; other site 1401659012991 ABC-ATPase subunit interface; other site 1401659012992 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 1401659012993 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1401659012994 Walker A/P-loop; other site 1401659012995 ATP binding site [chemical binding]; other site 1401659012996 Q-loop/lid; other site 1401659012997 ABC transporter signature motif; other site 1401659012998 Walker B; other site 1401659012999 D-loop; other site 1401659013000 H-loop/switch region; other site 1401659013001 transcriptional regulator PhoU; Provisional; Region: PRK11115 1401659013002 PhoU domain; Region: PhoU; pfam01895 1401659013003 PhoU domain; Region: PhoU; pfam01895 1401659013004 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 1401659013005 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 1401659013006 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 1401659013007 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1401659013008 active site 1401659013009 motif I; other site 1401659013010 motif II; other site 1401659013011 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1401659013012 Predicted flavoprotein [General function prediction only]; Region: COG0431 1401659013013 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1401659013014 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1401659013015 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1401659013016 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1401659013017 Biofilm formation and stress response factor; Region: BsmA; pfam10014 1401659013018 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1401659013019 Coenzyme A binding pocket [chemical binding]; other site 1401659013020 AzlC protein; Region: AzlC; cl00570 1401659013021 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1401659013022 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1401659013023 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1401659013024 ligand binding site [chemical binding]; other site 1401659013025 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 1401659013026 active site residue [active] 1401659013027 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1401659013028 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1401659013029 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1401659013030 G1 box; other site 1401659013031 GTP/Mg2+ binding site [chemical binding]; other site 1401659013032 Switch I region; other site 1401659013033 G2 box; other site 1401659013034 Switch II region; other site 1401659013035 G3 box; other site 1401659013036 G4 box; other site 1401659013037 G5 box; other site 1401659013038 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1401659013039 membrane protein insertase; Provisional; Region: PRK01318 1401659013040 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1401659013041 Ribonuclease P; Region: Ribonuclease_P; cl00457 1401659013042 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399