-- dump date 20140619_053705 -- class Genbank::CDS -- table cds_note -- id note YP_001436146.1 COG: COG0051 Ribosomal protein S10; Psort location: cytoplasmic, score: 23 YP_001436147.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_001436148.1 Psort location: cytoplasmic, score: 23 YP_001436149.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_001436151.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_001436153.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_001436154.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_001436155.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_001436156.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_001436157.1 COG: COG0197 Ribosomal protein L16/L10E; Psort location: cytoplasmic, score: 23 YP_001436158.1 one of the stabilizing components for the large ribosomal subunit YP_001436159.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_001436161.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_001436162.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_001436163.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_001436164.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif YP_001436166.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_001436167.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_001436168.1 binds 5S rRNA along with protein L5 and L25 YP_001436169.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_001436170.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_001436171.1 COG: COG0200 Ribosomal protein L15; Psort location: cytoplasmic, score: 23 YP_001436172.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_001436173.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif YP_001436174.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_001436175.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_001436176.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_001436177.1 COG: COG0203 Ribosomal protein L17; Psort location: cytoplasmic, score: 23 YP_001436178.1 COG: NOG18395 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001436179.1 mediates expression of the zinc export protein ZntA in response to high levels of zinc; member of MerR family of transcriptional regulators YP_001436180.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock YP_001436181.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain YP_001436182.1 catalyzes the methylation of cytosine at position 967 (m5C967) of 16S rRNA; SAM-dependent methyltransferase YP_001436183.1 KEGG: sdy:SDY_3464 1.4e-134 fmt; 10-formyltetrahydrofolate:L-meTHIonyl-tRNA(fMet) N-formyltransferase K00604; COG: COG0223 MeTHIonyl-tRNA formyltransferase; Psort location: cytoplasmic, score: 23 YP_001436184.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_001436185.1 COG: COG0758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake; Psort location: cytoplasmic, score: 23 YP_001436186.1 COG: COG2922 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001436187.1 KEGG: mca:MCA2839 2.3e-43 topA; DNA topoisomerase I K03168; COG: COG0551 Zn-finger domain associated with topoisomerase type I; Psort location: nuclear, score: 23 YP_001436188.1 RimN; YrdC; required for maturation of 16s RNA; binds preferentially double stranded RNA YP_001436189.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate YP_001436190.1 COG: NOG13911 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001436191.1 KEGG: eci:UTI89_C3724 4.2e-78 yrdA; protein YrdA K00680; COG: COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily; Psort location: cytoplasmic, score: 23 YP_001436193.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis YP_001436194.1 Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle YP_001436195.1 KEGG: sdy:SDY_4328 6.8e-220 aceA; isocitrate lyase K01637; COG: COG2224 Isocitrate lyase; Psort location: cytoplasmic, score: 23 YP_001436196.1 catalyzes the phosphorylation/dephosphorylation of the enzyme isocitrate dehydrogenase on a specific serine which regulates activity; unphosphorylated IDH is fully active when cells are grown on glucose while the enzyme becomes phosphorylated and inactive in the presence of acetate or ethanol YP_001436197.1 regulates the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase and isocitrate dehydrogenase kinase/phosphorylase YP_001436198.1 Psort location: cytoplasmic, score: 23 YP_001436199.1 one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity YP_001436200.1 COG: COG1283 Na+/phosphate symporter; Psort location: plasma membrane, score: 23 YP_001436201.1 COG: NOG14139 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001436202.1 KEGG: nfa:nfa24500 0.0025 putative arsenite transporter K03741:K03325; COG: COG0385 Predicted Na+-dependent transporter; Psort location: plasma membrane, score: 23 YP_001436203.1 KEGG: eci:UTI89_C2502 5.4e-37 atoC; acetoacetate metabolism regulatory protein AtoC K07714; COG: COG4650 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain; Psort location: cytoplasmic, score: 23 YP_001436204.1 Psort location: cytoplasmic, score: 23 YP_001436205.1 KEGG: reh:H16_A2768 1.7e-16 predicted membrane-bound protease subunit K01423; COG: COG0330 Membrane protease subunits, stomatin/prohibitin homologs; Psort location: cytoplasmic, score: 23 YP_001436206.1 COG: COG1690 Uncharacterized conserved protein; Psort location: endoplasmic reticulum, score: 9 YP_001436207.1 COG: COG3541 Predicted nucleotidyltransferase; Psort location: cytoplasmic, score: 23 YP_001436208.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive YP_001436209.1 Psort location: cytoplasmic, score: 23 YP_001436210.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_001436211.1 Psort location: mitochondrial, score: 23 YP_001436212.1 Psort location: cytoskeletal, score: 9 YP_001436214.1 COG: NOG14141 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001436215.1 COG: NOG06220 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001436216.1 COG: NOG06780 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001436217.1 COG: NOG06257 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001436218.1 KEGG: mpe:MYPE1700 1.4e-13 nodL; acetyl transferase K00680; COG: COG0110 Acetyltransferase (isoleucine patch superfamily); Psort location: cytoplasmic, score: 23 YP_001436219.1 KEGG: ngo:NGO0916 0.0034 dihydrolipoamide acetyltransferase K00658; COG: NOG12520 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001436220.1 with MalKFE is involved in the transport of maltose into the cell YP_001436221.1 with MalKGE is involved in maltose transport into the cell YP_001436222.1 functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis YP_001436223.1 with malEFG is involved in import of maltose/maltodextrin YP_001436224.1 porin involved in the transport of maltose and maltodextrins YP_001436225.1 KEGG: sco:SCO2181 0.00095 SC5F7.20, sucB; putative dihydrolipoamide succinyltransferase K00658; COG: NOG06298 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001436226.1 catalyzes the formation of 4-hydroxybenzoate from chorismate YP_001436227.1 catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway YP_001436228.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA YP_001436229.1 KEGG: sfx:S3568 7.4e-49 dgkA; diacylglycerol kinase K00901; COG: COG0818 Diacylglycerol kinase; Psort location: endoplasmic reticulum, score: 9 YP_001436230.1 Represses a number of genes involved in the response to DNA damage YP_001436231.1 COG: COG0534 Na+-driven multidrug efflux pump; Psort location: plasma membrane, score: 23 YP_001436232.1 unknown function; highly abundant protein in vivo; overexpressed under high NaCl concentrations; part of the sigma S regulon; non-essential YP_001436233.1 Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes znuACB YP_001436234.1 COG: COG3837 Uncharacterized conserved protein, contains double-stranded beta-helix domain; Psort location: cytoplasmic, score: 23 YP_001436235.1 COG: NOG11280 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001436236.1 KEGG: sec:SC4122 6.4e-153 yjbN; putative TIM-barrel enzymes, possibly dehydrogenases, nifR3 family K05539; COG: COG0042 tRNA-dihydrouridine synthase; Psort location: cytoplasmic, score: 23 YP_001436237.1 Psort location: mitochondrial, score: 23 YP_001436238.1 coordinately regulated along with pspA; PspF-dependent induction in response to secretin overexpression in Yersinia YP_001436239.1 KEGG: sty:STY4441 2.1e-145 qor; quinone oxidoreductase K00344; COG: COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases; Psort location: cytoplasmic, score: 23 YP_001436240.1 unwinds double stranded DNA YP_001436241.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer YP_001436242.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate YP_001436243.1 COG: COG2831 Hemolysin activation/secretion protein; Psort location: extracellular, including cell wall, score: 9 YP_001436244.1 COG: COG0432 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001436245.1 COG: COG2315 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001436246.1 COG: NOG29606 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001436247.1 COG: NOG26992 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001436248.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate YP_001436249.1 KEGG: shn:Shewana3_3590 1.4e-52 single-strand binding protein K00655; COG: COG0629 Single-stranded DNA-binding protein; Psort location: cytoplasmic, score: 23 YP_001436250.1 KEGG: bpm:BURPS1710b_A1493 1.4e-23 GGDEF domain protein; COG: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; Psort location: endoplasmic reticulum, score: 9 YP_001436251.1 COG: NOG14219 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001436252.1 Psort location: endoplasmic reticulum, score: 9 YP_001436253.1 Psort location: cytoplasmic, score: 23 YP_001436254.1 KEGG: shn:Shewana3_3829 9.0e-34 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) K01745; COG: COG4943 Predicted signal transduction protein containing sensor and EAL domains; Psort location: endoplasmic reticulum, score: 9 YP_001436255.1 regulates genes involved in response to oxidative stress YP_001436256.1 KEGG: eci:UTI89_C3737 9.9e-06 yhdM; Zn(II)-responsive regulator of ZntA; COG: COG0789 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001436257.1 KEGG: xac:XAC2394 2.4e-59 gstA; glutathione S-transferase K00799; COG: COG0625 glutathione S-transferase; Psort location: cytoplasmic, score: 23 YP_001436258.1 KEGG: bcz:BCZK0244 9.7e-63 guanine-hypoxanTHIne permease; xanTHIne/uracil permease family protein K06901; COG: COG2252 Permeases; Psort location: plasma membrane, score: 23 YP_001436259.1 COG: COG0025 NhaP-type Na+/H+ and K+/H+ antiporters; Psort location: plasma membrane, score: 23 YP_001436260.1 KEGG: ret:RHE_CH03170 6.7e-14 idhA; myo-inositol 2-dehydrogenase protein K00010; COG: COG0673 Predicted dehydrogenases and related proteins; Psort location: cytoplasmic, score: 23 YP_001436261.1 KEGG: rpr:RP465 1.2e-10 phoR; alkaline phosphatase synthesis sensor protein phoR K07636; COG: COG4147 Predicted symporter; Psort location: plasma membrane, score: 23 YP_001436262.1 KEGG: rba:RB12291 0.0092 probable NAD(P) transhydrogenase subunit alpha K00324; COG: COG3162 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001436263.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA YP_001436264.1 carrier protein part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system YP_001436265.1 Psort location: endoplasmic reticulum, score: 9 YP_001436266.1 Psort location: mitochondrial, score: 23 YP_001436267.1 KEGG: eci:UTI89_C0501 3.5e-25 htpG; chaperone HSP90, heat shock protein C 62.5 K04079; COG: COG0326 Molecular chaperone, HSP90 family; Psort location: endoplasmic reticulum, score: 9 YP_001436268.1 KEGG: reh:H16_B0196 0.0085 sbcC; DNA repair exonuclease, SbcC K01146; COG: NOG06085 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001436269.1 COG: NOG10268 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001436270.1 Psort location: cytoplasmic, score: 23 YP_001436271.1 COG: COG3625 Uncharacterized enzyme of phosphonate metabolism; Psort location: cytoplasmic, score: 23 YP_001436272.1 Psort location: mitochondrial, score: 23 YP_001436273.1 KEGG: eci:UTI89_C4702 1.4e-47 phnA; hypothetical protein PhnA K06193; COG: COG2824 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism; Psort location: cytoplasmic, score: 23 YP_001436274.1 KEGG: reh:H16_A0378 0.0030 predicted GTPase K01529; COG: COG0699 Predicted GTPases (dynamin-related); Psort location: cytoplasmic, score: 23 YP_001436275.1 COG: NOG06779 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001436276.1 transports degraded pectin products into the bacterial cell YP_001436277.1 Psort location: nuclear, score: 23 YP_001436278.1 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate YP_001436279.1 YghU; B2989; one of eight putative glutathione transferase proteins from E. coli YP_001436280.1 COG: COG2215 ABC-type uncharacterized transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001436281.1 Psort location: cytoplasmic, score: 23 YP_001436282.1 COG: COG3455 Uncharacterized protein conserved in bacteria; Psort location: vesicles of secretory system, score: 9 YP_001436283.1 COG: COG3523 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001436284.1 COG: COG3519 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001436285.1 COG: COG3520 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001436286.1 COG: COG3521 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001436287.1 COG: COG1309 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001436288.1 two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm YP_001436289.1 copper binding protein required for copper tolerance; involved in resistance toward heavy metals YP_001436290.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB YP_001436291.1 catalyzes the formation of fumarate from aspartate YP_001436292.1 F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein YP_001436293.1 KEGG: ftf:FTF1695 5.3e-23 groS; chaperonin protein, groES K04078; COG: COG0234 Co-chaperonin GroES (HSP10); Psort location: cytoplasmic, score: 23 YP_001436294.1 KEGG: eci:UTI89_C4741 1.4e-269 groEL; GroEL (chaperone HSP60) K04077; COG: COG0459 Chaperonin GroEL (HSP60 family); Psort location: cytoplasmic, score: 23 YP_001436295.1 COG: NOG09783 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001436296.1 KEGG: eci:UTI89_C4744 3.2e-158 yjeK; hypothetical protein YjeK K01843; COG: COG1509 Lysine 2,3-aminomutase; Psort location: cytoplasmic, score: 23 YP_001436297.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_001436298.1 COG: COG5510 Predicted small secreted protein; Psort location: extracellular, including cell wall, score: 9 YP_001436299.1 KEGG: ava:Ava_2028 0.0027 two component transcriptional regulator, LuxR family; COG: COG2771 DNA-binding HTH domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001436300.1 COG: COG2076 Membrane transporters of cations and cationic drugs; Psort location: endoplasmic reticulum, score: 9 YP_001436301.1 lipocalin; globomycin-sensitive outer membrane lipoprotein YP_001436302.1 in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane YP_001436303.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB YP_001436304.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB YP_001436305.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB YP_001436306.1 lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_001436307.1 KEGG: syn:sll1583 1.8e-07 lig, ligA; DNA ligase K01972; COG: COG3264 Small-conductance mechanosensitive channel; Psort location: endoplasmic reticulum, score: 9 YP_001436308.1 catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine YP_001436309.1 KEGG: ssn:SSO_4346 1.6e-115 yjeQ; hypothetical protein K06949; COG: COG1162 Predicted GTPases; Psort location: mitochondrial, score: 23 YP_001436310.1 Psort location: cytoplasmic, score: 23 YP_001436311.1 3'-5' exoribonuclease specific for small oligoribonuclotides YP_001436312.1 Psort location: nuclear, score: 23 YP_001436313.1 COG: COG1600 Uncharacterized Fe-S protein; Psort location: cytoplasmic, score: 23 YP_001436314.1 KEGG: reh:H16_A1504 2.2e-63 predicted sugar kinase K00924; COG: COG0063 Predicted sugar kinase; Psort location: cytoplasmic, score: 23 YP_001436315.1 possibly involved in cell wall synthesis YP_001436316.1 KEGG: eco:b4169 1.5e-183 amiB, yjeD; N-acetylmuramoyl-l-alanine amidase II, a murein hydrolase K01448; COG: COG0860 N-acetylmuramoyl-L-alanine amidase; Psort location: extracellular, including cell wall, score: 9 YP_001436317.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex YP_001436318.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_001436319.1 Stimulates the elongation of poly(A) tails YP_001436320.1 involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein YP_001436321.1 with HflC inhibits proteolysis of lambda cII protein by FtsH YP_001436322.1 with HflK inhibits proteolysis of lambda cII protein by FtsH YP_001436323.1 COG: COG3242 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001436324.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_001436325.1 negatively regulates the transcription of genes upregulated by nitrosative stress YP_001436326.1 3'-5'exoribonuclease that acts nonspecifically on poly(A), poly(U) and ribosomal RNAs YP_001436327.1 Specifically methylates the ribose of guanosine 2251 in 23S rRNA YP_001436328.1 COG: COG3766 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001436329.1 COG: COG5463 Predicted integral membrane protein; Psort location: nuclear, score: 23 YP_001436330.1 KEGG: vvy:VV2267 1.8e-102 glutaTHIonylspermidine synthase K01917; COG: COG0754 GlutaTHIonylspermidine synthase; Psort location: cytoplasmic, score: 23 YP_001436331.1 catalyzes the formation of 3-methylcrotonyl-CoA from isovaleryl-CoA YP_001436332.1 KEGG: reh:H16_B1458 2.3e-10 signal transduction histidine kinase; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 9 YP_001436333.1 Psort location: cytoplasmic, score: 23 YP_001436334.1 COG: NOG11343 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001436335.1 in Escherichia coli, mutation of this gene affects biofilm maturation, stress response, and motility YP_001436336.1 YjfP; esterase activity towards palmitoyl-CoA and pNP-butyrate in vitro; unknown function and substrate in vivo YP_001436337.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_001436338.1 binds single-stranded DNA at the primosome assembly site YP_001436339.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_001436341.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_001436342.1 COG: COG3061 Cell envelope opacity-associated protein A; Psort location: nuclear, score: 23 YP_001436343.1 Psort location: mitochondrial, score: 23 YP_001436344.1 FKBP-type; rotamase; catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides YP_001436345.1 involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine YP_001436346.1 Involved in anaerobic NO protection and iron metabolism YP_001436347.1 Psort location: cytoplasmic, score: 23 YP_001436348.1 KEGG: rde:RD1_3666 2.0e-06 torS; sensor protein TorS; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 9 YP_001436349.1 KEGG: sfl:SF3793 0.0092 uhpB; sensor histidine protein kinase phosphorylates UhpA K07675; COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: endoplasmic reticulum, score: 23 YP_001436350.1 COG: COG3506 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001436351.1 KEGG: bce:BC3740 3.3e-10 ADA regulatory protein K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: endoplasmic reticulum, score: 9 YP_001436352.1 COG: COG3755 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001436353.1 KEGG: eci:UTI89_C4820 1.4e-102 ytfG; hypothetical protein YtfG; COG: COG0702 Predicted nucleoside-diphosphate-sugar epimerases; Psort location: cytoplasmic, score: 23 YP_001436354.1 COG: COG1733 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001436355.1 periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate YP_001436356.1 catalyzes the formation of AMP from adenosine-3',5'-bisphosphate YP_001436357.1 COG: COG3054 Predicted transcriptional regulator; Psort location: extracellular, including cell wall, score: 9 YP_001436358.1 Psort location: cytoplasmic, score: 23 YP_001436359.1 COG: NOG17567 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001436360.1 KEGG: hpa:HPAG1_1423 6.5e-41 putative integral membrane protein with a TlyC-like hemolysin domain K00088; COG: COG1253 Hemolysins and related proteins containing CBS domains; Psort location: endoplasmic reticulum, score: 9 YP_001436361.1 COG: NOG24086 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001436362.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress YP_001436363.1 Psort location: cytoplasmic, score: 23 YP_001436364.1 COG: COG0729 Outer membrane protein; Psort location: extracellular, including cell wall, score: 9 YP_001436365.1 KEGG: bmf:BAB1_0046 1.2e-13 family of unknown function DUF490 K01076; COG: COG2911 Uncharacterized protein conserved in bacteria; Psort location: mitochondrial, score: 23 YP_001436366.1 COG: COG2105 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001436367.1 KEGG: gvi:glr0861 2.7e-05 two-component sensor histidine kinase; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 9 YP_001436368.1 catalyzes the hydrolysis of pyrophosphate to phosphate YP_001436369.1 Psort location: cytoplasmic, score: 23 YP_001436370.1 Psort location: nuclear, score: 23 YP_001436371.1 KEGG: msm:MSMEG_3095 2.0e-30 D-ribose-binding periplasmic protein; COG: COG1879 ABC-type sugar transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001436372.1 Psort location: cytoplasmic, score: 23 YP_001436373.1 KEGG: eco:b4485 1.4e-228 ytfR, ytfS; predicted sugar transporter subunit: ATP-binding component of ABC superfamily K02056; COG: COG1129 ABC-type sugar transport system, ATPase component; Psort location: endoplasmic reticulum, score: 9 YP_001436374.1 KEGG: msm:MSMEG_1710 1.5e-73 ribose transport system permease protein RbsC; COG: COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001436375.1 membrane component of a putative sugar ABC transporter system YP_001436376.1 KEGG: abo:ABO_1307 7.4e-06 sensor histidine kinase/respose regulator; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 9 YP_001436377.1 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate YP_001436378.1 KEGG: stm:STM4416 2.4e-233 mpl; UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase K02558; COG: COG0773 UDP-N-acetylmuramate-alanine ligase; Psort location: mitochondrial, score: 23 YP_001436379.1 COG: NOG10872 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001436380.1 COG: COG3028 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001436381.1 protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD YP_001436382.1 KEGG: eco:b4236 1.8e-36 cybC; cytochrome b562, truncated (pseudogene); COG: COG3783 Soluble cytochrome b562; Psort location: extracellular, including cell wall, score: 9 YP_001436383.1 Psort location: mitochondrial, score: 23 YP_001436384.1 COG: NOG18554 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001436385.1 COG: NOG11467 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001436386.1 COG: NOG18555 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001436387.1 COG: NOG07923 non supervised orthologous group; Psort location: plasma membrane, score: 23 YP_001436388.1 KEGG: rpa:RPA1257 0.0038 cobS; possible cobalamin (5'-phosphate) synthase K02233; COG: NOG08746 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001436389.1 KEGG: btl:BALH_4413 1.2e-62 possible dihydroorotase K01486; COG: COG3964 Predicted amidohydrolase; Psort location: cytoplasmic, score: 23 YP_001436390.1 KEGG: pcr:Pcryo_1934 3.4e-05 imidazolonepropionase K01468; COG: COG3964 Predicted amidohydrolase; Psort location: cytoplasmic, score: 23 YP_001436391.1 KEGG: efa:EF0838 2.3e-102 pyridoxal phosphate-dependent enzyme, putative K01042; COG: COG1921 Selenocysteine synthase [seryl-tRNASer selenium transferase]; Psort location: cytoplasmic, score: 23 YP_001436392.1 KEGG: msm:MSMEG_3788 7.9e-05 eda; 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase K01625:K01650; COG: NOG08125 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001436393.1 KEGG: spi:MGAS10750_Spy1176 1.1e-32 transcription antiterminator, BglG family / PTS system, mannitol (cryptic)-specific IIA component K00890; COG: COG4668 Mannitol/fructose-specific phosphotransferase system, IIA domain; Psort location: cytoplasmic, score: 23 YP_001436394.1 Qin prophage; bifunctional antitoxin of the RelE-RelB toxin-antitoxin system/transcriptional repressor YP_001436395.1 COG: COG2026 Cytotoxic translational repressor of toxin-antitoxin stability system; Psort location: cytoplasmic, score: 23 YP_001436396.1 activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions YP_001436397.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates YP_001436398.1 KEGG: shn:Shewana3_3435 5.2e-07 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001436399.1 KEGG: gvi:glr1342 5.1e-41 probable NADP(H) oxidoreductase; COG: COG2249 Putative NADPH-quinone reductase (modulator of drug activity B); Psort location: cytoplasmic, score: 23 YP_001436400.1 KEGG: stt:t4488 3.0e-249 treC; trehalose-6-phosphate hydrolase K01226; COG: COG0366 Glycosidases; Psort location: cytoplasmic, score: 23 YP_001436401.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_001436402.1 regulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon YP_001436403.1 COG: COG1309 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001436404.1 cofactor involved in the reduction of disulfides YP_001436405.1 COG: COG1359 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001436406.1 COG: NOG06777 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001436407.1 methylglyoxal reductase/#-keto ester reductase; catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; also catalyzes the reduction of methylglyoxal, ethyl-2-methylacetoacetate and ethyl-acetoacetate YP_001436408.1 KEGG: eco:b3011 1.6e-181 yqhD; putative alcohol dehydrogenase K08325; COG: COG1979 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family; Psort location: cytoplasmic, score: 23 YP_001436409.1 KEGG: bli:BL05281 1.1e-07 adaA; methylphosphotriester-DNA alkyltransferase and transcriptional regulator (AraC/XylS family) K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001436410.1 KEGG: sab:SAB2386 9.1e-08 probable alkaline phosphatase K01077; COG: COG0586 Uncharacterized membrane-associated protein; Psort location: endoplasmic reticulum, score: 9 YP_001436411.1 Psort location: mitochondrial, score: 23 YP_001436412.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell YP_001436413.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell YP_001436414.1 KEGG: sec:SC3099 7.8e-132 yghA; putative oxidoreductase; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001436415.1 regulates expression of genes involved in L-fucose utilization YP_001436416.1 COG: NOG30084 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001436417.1 COG: NOG27696 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001436418.1 Psort location: extracellular, including cell wall, score: 9 YP_001436419.1 COG: COG2862 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001436420.1 KEGG: rle:pRL120603 0.0043 gabD; putative succinate-semialdehyde dehydrogenase (NADP+) K00135; COG: COG0668 Small-conductance mechanosensitive channel; Psort location: plasma membrane, score: 23 YP_001436421.1 COG: COG4580 Maltoporin (phage lambda and maltose receptor); Psort location: endoplasmic reticulum, score: 9 YP_001436422.1 KEGG: eca:ECA2489 3.1e-41 PTS system, cellobiose-specific IIa component K02759; COG: COG1447 Phosphotransferase system cellobiose-specific component IIA; Psort location: cytoplasmic, score: 23 YP_001436423.1 KEGG: eca:ECA2488 1.5e-194 PTS system, cellobiose-specific IIc component K02761; COG: COG1455 Phosphotransferase system cellobiose-specific component IIC; Psort location: plasma membrane, score: 23 YP_001436424.1 KEGG: ppr:PBPRB2008 2.5e-32 celA; hypothetical cellobiose-specific IIB component, PTS system K02760; COG: COG1440 Phosphotransferase system cellobiose-specific component IIB; Psort location: cytoplasmic, score: 23 YP_001436425.1 Psort location: cytoplasmic, score: 23 YP_001436426.1 KEGG: efa:EF1922 0.00016 transcriptional regulator, LacI family/carbohydrate kinase, PfkB family protein K00852; COG: COG1609 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001436427.1 KEGG: fal:FRAAL1007 0.0016 ubiA; 4-hydroxybenzoate octaprenyltransferase K03179; COG: COG3647 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001436428.1 COG: COG3501 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001436429.1 KEGG: cvi:CV0024 4.0e-43 probable hydroxyethylTHIazole kinase K00878; COG: NOG11775 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001436430.1 Psort location: mitochondrial, score: 23 YP_001436431.1 Psort location: cytoplasmic, score: 23 YP_001436432.1 Psort location: endoplasmic reticulum, score: 9 YP_001436433.1 Psort location: cytoplasmic, score: 23 YP_001436434.1 COG: NOG25000 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001436435.1 COG: NOG18467 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001436436.1 COG: NOG18467 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001436437.1 Psort location: nuclear, score: 23 YP_001436438.1 Psort location: cytoplasmic, score: 23 YP_001436439.1 KEGG: fal:FRAAL6221 1.2e-58 putative poly(beta-D-mannuronate) O-acetylase (alginate biosynthesis protein AlgI) K00680; COG: COG1696 Predicted membrane protein involved in D-alanine export; Psort location: plasma membrane, score: 23 YP_001436440.1 KEGG: cme:CMM178C 0.0089 NADH dehydrogenase type II, chloroplast precursor K03885; COG: COG2845 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001436441.1 COG: COG2755 Lysophospholipase L1 and related esterases; Psort location: cytoplasmic, score: 23 YP_001436442.1 COG: COG4685 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 23 YP_001436443.1 COG: COG3234 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001436444.1 COG: COG2373 Large extracellular alpha-helical protein; Psort location: extracellular, including cell wall, score: 9 YP_001436445.1 COG: COG5445 Predicted secreted protein; Psort location: extracellular, including cell wall, score: 9 YP_001436446.1 COG: COG4676 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001436447.1 COG: COG1811 Uncharacterized membrane protein, possible Na+ channel or pump; Psort location: endoplasmic reticulum, score: 9 YP_001436448.1 Psort location: mitochondrial, score: 23 YP_001436449.1 KEGG: ecc:c3553 0. speC; orniTHIne decarboxylase, constitutive K01581; COG: COG1982 Arginine/lysine/orniTHIne decarboxylases; Psort location: extracellular, including cell wall, score: 9 YP_001436450.1 KEGG: btl:BALH_0517 2.1e-21 response regulator; COG: COG4565 Response regulator of citrate/malate metabolism; Psort location: cytoplasmic, score: 23 YP_001436451.1 KEGG: eca:ECA2577 7.1e-170 citA; two-component sensor kinase K07700; COG: COG3290 Signal transduction histidine kinase regulating citrate/malate metabolism; Psort location: endoplasmic reticulum, score: 9 YP_001436452.1 Psort location: mitochondrial, score: 23 YP_001436453.1 COG: COG3493 Na+/citrate symporter; Psort location: plasma membrane, score: 23 YP_001436454.1 KEGG: reu:Reut_B5809 3.0e-68 5-carboxymethyl-2-hydroxymuconate delta-isomerase K01826; COG: COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway); Psort location: cytoplasmic, score: 23 YP_001436455.1 KEGG: eca:ECA2574 1.6e-94 citC; [citrate [pro-3s]-lyase] ligase K01910; COG: COG3053 Citrate lyase synthetase; Psort location: cytoplasmic, score: 23 YP_001436456.1 acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate YP_001436457.1 KEGG: eca:ECA2572 3.0e-130 citE; citrate lyase beta chain K01644; COG: COG2301 Citrate lyase beta subunit; Psort location: cytoplasmic, score: 23 YP_001436458.1 KEGG: eca:ECA2571 2.8e-49 citF; citrate lyase alpha chain K01643; COG: COG3051 Citrate lyase, alpha subunit; Psort location: cytoplasmic, score: 23 YP_001436459.1 Psort location: cytoplasmic, score: 23 YP_001436460.1 KEGG: eca:ECA2571 8.8e-156 citF; citrate lyase alpha chain K01643; COG: COG3051 Citrate lyase, alpha subunit; Psort location: cytoplasmic, score: 23 YP_001436461.1 KEGG: eca:ECA2570 1.7e-40 citX; apo-citrate lyase phosphoribosyl-dephospho-CoA transferase K05964; COG: COG3697 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase); Psort location: cytoplasmic, score: 23 YP_001436462.1 KEGG: eca:ECA2569 2.0e-71 citG; 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase K05966; COG: COG1767 Triphosphoribosyl-dephospho-CoA synthetase; Psort location: cytoplasmic, score: 23 YP_001436463.1 Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues YP_001436464.1 COG: COG2924 Fe-S cluster protector protein; Psort location: extracellular, including cell wall, score: 9 YP_001436465.1 KEGG: spt:SPA2973 8.0e-162 mutY; A/G-specific adenine glycosylase K03575; COG: COG1194 A/G-specific DNA glycosylase; Psort location: cytoplasmic, score: 23 YP_001436466.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine YP_001436467.1 COG: COG3171 Uncharacterized protein conserved in bacteria; Psort location: mitochondrial, score: 23 YP_001436468.1 COG: NOG06291 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001436469.1 Psort location: mitochondrial, score: 23 YP_001436470.1 Psort location: cytoplasmic, score: 23 YP_001436471.1 COG: COG1598 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001436472.1 KEGG: reh:H16_A0195 5.9e-56 putative GTPase (G3E family); COG: COG0523 Putative GTPases (G3E family); Psort location: cytoplasmic, score: 23 YP_001436473.1 COG: COG2879 Uncharacterized small protein; Psort location: cytoplasmic, score: 23 YP_001436474.1 COG: COG1966 Carbon starvation protein, predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001436475.1 KEGG: reh:H16_B0196 2.4e-05 sbcC; DNA repair exonuclease, SbcC K01146; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 9 YP_001436476.1 KEGG: chu:CHU_2038 1.8e-20 crtZ; beta-carotene hydroxylase K00492; COG: NOG14527 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001436477.1 KEGG: plu:plu4343 3.8e-100 crtB; phytoene synthase K02291; COG: COG1562 Phytoene/squalene synthetase; Psort location: cytoplasmic, score: 23 YP_001436478.1 KEGG: rsp:RSP_0271 2.0e-101 crtI; phytoene dehydrogenase K00258; COG: COG1233 Phytoene dehydrogenase and related proteins; Psort location: extracellular, including cell wall, score: 9 YP_001436479.1 KEGG: syc:syc2031_d 4.5e-06 crtL; lycopene cyclase K06444; COG: NOG08858 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001436480.1 KEGG: mxa:MXAN_0593 9.1e-16 glycosyltransferase, MGT family K00754; COG: COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase; Psort location: cytoplasmic, score: 23 YP_001436481.1 catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate YP_001436482.1 KEGG: hne:HNE_1839 2.3e-38 ispA; geranyltranstransferase K00795; COG: COG0142 Geranylgeranyl pyrophosphate synthase; Psort location: endoplasmic reticulum, score: 9 YP_001436483.1 COG: COG3054 Predicted transcriptional regulator; Psort location: extracellular, including cell wall, score: 9 YP_001436484.1 Psort location: extracellular, including cell wall, score: 9 YP_001436485.1 Psort location: cytoplasmic, score: 23 YP_001436486.1 Psort location: nuclear, score: 23 YP_001436487.1 KEGG: ssn:SSO_3206 2.0e-69 ygjF; hypothetical protein K03649; COG: COG3663 G:T/U mismatch-specific DNA glycosylase; Psort location: cytoplasmic, score: 23 YP_001436488.1 Psort location: extracellular, including cell wall, score: 9 YP_001436489.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria YP_001436490.1 synthesizes RNA primers at the replication forks YP_001436491.1 Psort location: mitochondrial, score: 23 YP_001436492.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_001436493.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX YP_001436494.1 KEGG: spt:SPA3074 5.2e-48 folB; dihydroneopterin aldolase K01633; COG: COG1539 Dihydroneopterin aldolase; Psort location: cytoplasmic, score: 23 YP_001436495.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell YP_001436496.1 catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases YP_001436497.1 KEGG: lmf:LMOf2365_1540 0.00028 ami; N-acetylmuramoyl-L-alanine amidase, family 3 K01448; COG: COG3103 SH3 domain protein; Psort location: endoplasmic reticulum, score: 9 YP_001436498.1 KEGG: aha:AHA_3770 2.2e-40 adenylate cyclase K01768; COG: COG3025 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001436499.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme YP_001436500.1 catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose YP_001436501.1 KEGG: cme:CMA103C 0.00053 Raf-related MAP kinase kinase kinase (MAP3K), theta-type K00870; COG: COG2960 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001436502.1 DHBP synthase; functions during riboflavin biosynthesis YP_001436503.1 KEGG: rxy:Rxyl_0125 0.0023 NADH dehydrogenase (quinone) K05903; COG: COG0428 Predicted divalent heavy-metal cations transporter; Psort location: endoplasmic reticulum, score: 9 YP_001436504.1 seems to be involved in biofilm formation; in asymptomatic bacteriuria E. coli strains 83972 and VR50, the ygiD gene is upregulated during biofilm formation in urine YP_001436505.1 KEGG: vvy:VV2267 2.7e-122 glutaTHIonylspermidine synthase K01917; COG: COG0754 GlutaTHIonylspermidine synthase; Psort location: cytoskeletal, score: 9 YP_001436506.1 COG: COG5463 Predicted integral membrane protein; Psort location: nuclear, score: 23 YP_001436507.1 trimeric outer membrane protein involved in efflux of hydrophobic/amphipathic molecules; functions with a number of efflux systems in the inner membrane to transport molecules out of the cell YP_001436508.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose YP_001436509.1 COG: COG3151 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001436510.1 KEGG: eci:UTI89_C3466 7.4e-120 icc; icc protein K03651; COG: COG1409 Predicted phosphohydrolases; Psort location: cytoplasmic, score: 23 YP_001436511.1 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate YP_001436512.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_001436513.1 KEGG: sec:SC3998 0. katG; catalase; hydroperoxidase HPI(I) K03782; COG: COG0376 Catalase (peroxidase I); Psort location: cytoplasmic, score: 23 YP_001436514.1 COG: COG1359 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001436515.1 KEGG: eci:UTI89_C3455 4.3e-92 mdaB; modulator of drug activity B K03923; COG: COG2249 Putative NADPH-quinone reductase (modulator of drug activity B); Psort location: cytoplasmic, score: 23 YP_001436516.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_001436517.1 KEGG: eco:b3018 7.5e-111 plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase K00655; COG: COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase; Psort location: endoplasmic reticulum, score: 9 YP_001436518.1 KEGG: eci:UTI89_C3443 1.1e-228 sufI; FtsI suppressor K04753; COG: COG2132 Putative multicopper oxidases; Psort location: mitochondrial, score: 23 YP_001436519.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_001436520.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine YP_001436521.1 KEGG: lma:LmjF04.1190 0.0098 tRNA nucleotidyltransferase, putative; COG: COG1872 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001436522.1 COG: COG0762 Predicted integral membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001436523.1 KEGG: eci:UTI89_C3340 3.2e-96 yggS; hypothetical protein; COG: COG0325 Predicted enzyme with a TIM-barrel fold; Psort location: cytoplasmic, score: 23 YP_001436524.1 KEGG: pen:PSEEN2333 3.6e-33 xcpR-2; type II secretion pathway protein E K01509; COG: COG2805 Tfp pilus assembly protein, pilus retraction ATPase PilT; Psort location: cytoplasmic, score: 23 YP_001436525.1 KEGG: atc:AGR_L_1103 3.4e-05 sarcosine oxidase alpha subunit K00302; COG: NOG08355 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001436526.1 COG: COG1414 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001436527.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function YP_001436528.1 COG: COG1678 Putative transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001436529.1 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione YP_001436530.1 COG: COG1385 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001436531.1 KEGG: eco:b2945 1.7e-106 endA; DNA-specific endonuclease I K01150; COG: COG2356 Endonuclease I; Psort location: extracellular, including cell wall, score: 9 YP_001436532.1 COG: COG3091 Uncharacterized protein conserved in bacteria; Psort location: mitochondrial, score: 23 YP_001436533.1 KEGG: cal:orf19.3526 9.8e-54 ITR2; myo-inositol transporter K08140; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001436534.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_001436535.1 Psort location: mitochondrial, score: 23 YP_001436536.1 catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis YP_001436537.1 catalyzes the formation of putrescine from agmatine YP_001436538.1 Psort location: cytoplasmic, score: 23 YP_001436539.1 KEGG: stt:t2997 7.3e-113 putative metalloprotease K07387; COG: COG0501 Zn-dependent protease with chaperone function; Psort location: nuclear, score: 23 YP_001436540.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase YP_001436541.1 KEGG: azo:azo2644 7.7e-86 draG2; putative ADP-ribosyl-[dinitrogen reductase] hydrolase; COG: COG1397 ADP-ribosylglycohydrolase; Psort location: cytoplasmic, score: 23 YP_001436542.1 NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate YP_001436543.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_001436544.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate YP_001436545.1 participates in the regulation of osmotic pressure changes within the cel YP_001436546.1 Involved in the export of arginine YP_001436547.1 COG: COG2968 Uncharacterized conserved protein; Psort location: nuclear, score: 23 YP_001436548.1 specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport YP_001436549.1 KEGG: ecc:c3495 8.0e-107 rpiA; ribose 5-phosphate isomerase A K01807; COG: COG0120 Ribose 5-phosphate isomerase; Psort location: cytoplasmic, score: 23 YP_001436550.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate YP_001436551.1 KEGG: shn:Shewana3_3505 8.5e-16 fructose-bisphosphatase K01086; COG: COG3027 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001436552.1 the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown YP_001436553.1 exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide YP_001436554.1 Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone YP_001436555.1 KEGG: ssn:SSO_3059 3.1e-176 visC; hypothetical protein; COG: COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases; Psort location: cytoplasmic, score: 23 YP_001436556.1 Psort location: cytoplasmic, score: 23 YP_001436557.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein YP_001436558.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor YP_001436559.1 Psort location: cytoplasmic, score: 23 YP_001436560.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine YP_001436561.1 KEGG: sfx:S3087 7.6e-102 ygfF; putative oxidoreductase; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001436562.1 KEGG: ecp:ECP_2895 1.6e-252 6-phospho-beta-glucosidase BglA K01223; COG: COG2723 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase; Psort location: cytoplasmic, score: 23 YP_001436563.1 KEGG: bxe:Bxe_A3454 9.8e-09 glucokinase K00845; COG: COG1737 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001436564.1 COG: COG3097 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001436565.1 COG: COG1272 Predicted membrane protein, hemolysin III homolog; Psort location: plasma membrane, score: 23 YP_001436566.1 physiological role is not clear; not essential for growth but mutants grow poorly; mutations suppress hda null mutations; may be involved in regulation of ATP-DnaA levels; may also be involved in regulation of tRNA modifications; can bind folic acid and tetrahydrofolate; forms a three domain ring-like structure with a central channel; structurally similar to DMGO protein from A. globiformis; shows sequence similarity to yeast CAF17 transcriptional regulator YP_001436567.1 COG: COG2938 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001436568.1 COG: NOG09016 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001436569.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic YP_001436570.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_001436571.1 DsbC; periplasmic protein with protein disulfide isomerase activity; this protein also shows disulfide oxidoreductase activity YP_001436572.1 5'-3' single-stranded-DNA-specific exonuclease YP_001436573.1 Psort location: cytoplasmic, score: 23 YP_001436574.1 KEGG: reh:H16_A1169 1.3e-106 prfB; protein chain release factor B (RF-2); COG: COG1186 Protein chain release factor B; Psort location: cytoskeletal, score: 9 YP_001436575.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 YP_001436576.1 KEGG: eci:UTI89_C3250 8.2e-50 ygeR; hypothetical lipoprotein YgeR precursor; COG: COG0739 Membrane proteins related to metalloendopeptidases; Psort location: nuclear, score: 23 YP_001436577.1 COG: COG1280 Putative threonine efflux protein; Psort location: endoplasmic reticulum, score: 9 YP_001436578.1 COG: NOG26670 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001436579.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis YP_001436580.1 COG: NOG06222 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001436581.1 KEGG: yps:YPTB2368 2.0e-151 ogl; oligogalacturonate lyase K01730; COG: COG0823 Periplasmic component of the Tol biopolymer transport system; Psort location: cytoplasmic, score: 23 YP_001436582.1 Psort location: nuclear, score: 23 YP_001436583.1 Psort location: cytoplasmic, score: 23 YP_001436584.1 catalyzes the formation of 3-dehydro-2-deoxy-D-gluconate from 2-deoxy-D-gluconate YP_001436585.1 KEGG: eci:UTI89_C1581 1.6e-06 ycjN; putative ABC transporter periplasmic binding protein YcjN precursor K02027; COG: COG1653 ABC-type sugar transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001436586.1 KEGG: yps:YPTB3446 8.3e-57 ABC sugar transporter, ATP-binding subunit K02028; COG: COG3839 ABC-type sugar transport systems, ATPase components; Psort location: cytoplasmic, score: 23 YP_001436587.1 KEGG: reh:H16_A2327 8.5e-48 ABC-type transporter, ATPase component: CUT1 family; COG: COG3839 ABC-type sugar transport systems, ATPase components; Psort location: cytoplasmic, score: 23 YP_001436588.1 COG: COG0395 ABC-type sugar transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001436589.1 KEGG: ava:Ava_0243 0.0036 molybdate ABC transporter, permease protein K02018; COG: COG1175 ABC-type sugar transport systems, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001436590.1 Psort location: mitochondrial, score: 23 YP_001436591.1 part of the ferric enterobactin transport system; necessary for enetrobactin uptake YP_001436592.1 KEGG: nph:NP3568A 0.00015 homolog 3 to mannose-1-phosphate guanylyltransferase (GDP) K00971; COG: COG1917 Uncharacterized conserved protein, contains double-stranded beta-helix domain; Psort location: cytoplasmic, score: 23 YP_001436593.1 KEGG: eci:UTI89_C3244 3.1e-89 ygeA; hypothetical protein YgeA K01779; COG: COG1794 Aspartate racemase; Psort location: cytoplasmic, score: 23 YP_001436594.1 activates the transcription of the lysA gene encoding diaminopimelate decarboxylase YP_001436595.1 catalyzes the decarboxylation of diaminopimelate into lysine; pyridoxal phosphate(PLP)-binding YP_001436596.1 KEGG: efa:EF1922 1.1e-10 transcriptional regulator, LacI family/carbohydrate kinase, PfkB family protein K00852; COG: COG1609 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001436597.1 KEGG: bcz:BCZK4903 3.7e-70 celB; PTS system, cellobiose-specific IIC component K02761; COG: COG1455 Phosphotransferase system cellobiose-specific component IIC; Psort location: plasma membrane, score: 23 YP_001436598.1 KEGG: eca:ECA3646 4.3e-202 celH; putative 6-phospho-beta-glucosidase K05350; COG: COG2723 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase; Psort location: cytoplasmic, score: 23 YP_001436599.1 KEGG: eca:ECA3645 5.0e-34 PTS system, lichenan-specific IIb component K02760; COG: COG1440 Phosphotransferase system cellobiose-specific component IIB; Psort location: cytoplasmic, score: 23 YP_001436600.1 KEGG: reh:H16_B1289 5.7e-08 phnF; regulator of phosphonate operon, GntR-family; COG: COG2186 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001436601.1 KEGG: reh:H16_B1278 0.00017 predicted acetyltransferase K00680; COG: NOG22247 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001436602.1 controls transcription of galETKM YP_001436603.1 Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1 YP_001436604.1 KEGG: pca:Pcar_2776 4.4e-23 2-acyl-glycerophospho-ethanolamine acyltransferase K05939:K01909; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001436605.1 complements the prephenate dehydrogenase dysfunction of an Escherichia coli tyrosine auxotroph strain; member of the aldo/keto reductase 2 family; crystal structure of purified Escherichia coli protein shows bound NADPH YP_001436606.1 Psort location: cytoplasmic, score: 23 YP_001436607.1 COG: NOG13901 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001436608.1 COG: COG0861 Membrane protein TerC, possibly involved in tellurium resistance; Psort location: endoplasmic reticulum, score: 23 YP_001436609.1 MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair YP_001436610.1 hydrolyzes diadenosine polyphosphate YP_001436611.1 member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr YP_001436612.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein YP_001436613.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived YP_001436614.1 COG: COG2165 Type II secretory pathway, pseudopilin PulG; Psort location: mitochondrial, score: 23 YP_001436615.1 COG: COG4795 Type II secretory pathway, component PulJ; Psort location: mitochondrial, score: 23 YP_001436616.1 COG: NOG10274 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001436617.1 COG: COG4967 Tfp pilus assembly protein PilV; Psort location: cytoplasmic, score: 23 YP_001436618.1 catalyzes ATP-dependent exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides; component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination YP_001436619.1 KEGG: sec:SC2933 0. ptr; protease III K01407; COG: COG1025 Secreted/periplasmic Zn-dependent peptidases, insulinase-like; Psort location: cytoplasmic, score: 23 YP_001436620.1 helicase/nuclease; with RecCD catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity YP_001436621.1 helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity YP_001436622.1 catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis YP_001436623.1 Psort location: cytoplasmic, score: 23 YP_001436624.1 Psort location: cytoplasmic, score: 23 YP_001436625.1 KEGG: sty:STY3129 3.8e-187 N-acetylmuramoyl-L-alanine amidase K01448; COG: COG0860 N-acetylmuramoyl-L-alanine amidase; Psort location: extracellular, including cell wall, score: 9 YP_001436626.1 membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues YP_001436627.1 KEGG: cal:orf19.2115 4.3e-25 molybdopterin-converting factor; COG: COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and THIamine biosynthesis family 1; Psort location: cytoplasmic, score: 23 YP_001436628.1 KEGG: cps:CPS_2211 1.1e-16 putative selenocysteine lyase K02426; COG: COG2166 SufE protein probably involved in Fe-S center assembly; Psort location: cytoplasmic, score: 23 YP_001436629.1 KEGG: eco:b2810 2.9e-173 csdA, ygdJ; cysteine sulfinate desulfinase; COG: COG0520 Selenocysteine lyase; Psort location: cytoplasmic, score: 23 YP_001436630.1 COG: NOG14132 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001436631.1 Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence YP_001436632.1 COG: COG2363 Uncharacterized small membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001436633.1 KEGG: vfi:VF0593 4.1e-126 methyltransferase; COG: COG2933 Predicted SAM-dependent methyltransferase; Psort location: cytoplasmic, score: 23 YP_001436634.1 KEGG: ecs:ECs3658 2.1e-106 5'-3' exonuclease K01146; COG: COG0258 5-3 exonuclease (including N-terminal domain of PolI); Psort location: cytoplasmic, score: 23 YP_001436635.1 KEGG: sfl:SF2811 1.1e-221 sdaB; L-serine dehydratase (deaminase), L-SD2 K01752; COG: COG1760 L-serine deaminase; Psort location: cytoplasmic, score: 23 YP_001436636.1 COG: COG0814 Amino acid permeases; Psort location: plasma membrane, score: 23 YP_001436637.1 Psort location: nuclear, score: 23 YP_001436638.1 KEGG: hch:HCH_00651 3.4e-131 predicted Rossmann fold nucleotide-binding protein K00052; COG: COG1611 Predicted Rossmann fold nucleotide-binding protein; Psort location: cytoplasmic, score: 23 YP_001436639.1 catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis YP_001436640.1 putative SecY regulator that either chelates excess SecY or negatively regulates the SecYE translocase function YP_001436641.1 KEGG: shn:Shewana3_2825 2.7e-12 dTDP-4-dehydrorhamnose 3,5-epimerase K01790; COG: COG3098 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001436642.1 catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp YP_001436643.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_001436644.1 part of the two-component regulatory system with UvrY; involved in the regulation of carbon metabolism via the csrA/csrB regulatory system YP_001436645.1 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S] YP_001436646.1 (p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP YP_001436647.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era YP_001436648.1 Psort location: cytoplasmic, score: 23 YP_001436649.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_001436650.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_001436651.1 COG: NOG13748 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001436652.1 KEGG: azo:azo3173 5.3e-18 galE1; UDP-glucose 4-epimerase K01784; COG: COG0451 Nucleoside-diphosphate-sugar epimerases; Psort location: cytoplasmic, score: 23 YP_001436653.1 Psort location: cytoplasmic, score: 23 YP_001436654.1 KEGG: bte:BTH_I1550 5.1e-29 glucokinase/transcriptional regulator, RpiR family, fusion K00845; COG: COG1737 Transcriptional regulators; Psort location: vesicles of secretory system, score: 23 YP_001436655.1 KEGG: bcl:ABC0713 6.2e-203 PTS system, glucose-specific enzyme II, ABC component K02790:K02791; COG: COG1263 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific; Psort location: plasma membrane, score: 23 YP_001436656.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate YP_001436657.1 COG: COG1512 Beta-propeller domains of methanol dehydrogenase type; Psort location: endoplasmic reticulum, score: 9 YP_001436658.1 KEGG: hpa:HPAG1_0914 3.5e-07 hypothetical protein K04071; COG: COG0602 Organic radical activating enzymes; Psort location: cytoplasmic, score: 23 YP_001436659.1 KEGG: sfl:SF2781 1.5e-59 ygcM; putative 6-pyruvoyl tetrahydrobiopterin synthase K01737; COG: COG0720 6-pyruvoyl-tetrahydropterin synthase; Psort location: cytoplasmic, score: 23 YP_001436660.1 Psort location: mitochondrial, score: 23 YP_001436661.1 catalyzes the reduction of sulfite to sulfide in the biosynthesis of L-cysteine from sulfate; a flavoprotein with flavin reductase activity YP_001436662.1 hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide YP_001436663.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite YP_001436664.1 catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3 YP_001436665.1 KEGG: eca:ECA3544 7.3e-168 cysG1; siroheme synthase [includes: uroporphyrin-III C-methyltransferase; precorrin-2 oxidase; ferrochelatase] K02302:K02303:K02304; COG: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); Psort location: cytoplasmic, score: 23 YP_001436666.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP YP_001436667.1 may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ YP_001436668.1 converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis YP_001436669.1 COG: NOG12170 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001436670.1 forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein YP_001436671.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers YP_001436672.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate YP_001436673.1 catalyzes the modification of U13 in tRNA(Glu) YP_001436674.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate YP_001436675.1 catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins YP_001436676.1 outer membrane lipoprotein involved in stationary-phase cell survival; similar to LppB virulence determinant from Haemophilus somnus YP_001436677.1 COG: COG4460 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001436678.1 KEGG: sgl:SG1466 2.1e-08 dethiobiotinsynthase K01935; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001436679.1 COG: COG0583 Transcriptional regulator; Psort location: extracellular, including cell wall, score: 9 YP_001436680.1 COG: COG1846 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001436681.1 KEGG: sdy:SDY_2938 1.2e-82 phenylacrylic acid decarboxylase-like protein K03186; COG: COG0163 3-polyprenyl-4-hydroxybenzoate decarboxylase; Psort location: cytoplasmic, score: 23 YP_001436682.1 KEGG: gvi:gll3010 3.2e-55 3-octaprenyl-4-hydroxybenzoate carboxy-lyase UbiD K03182; COG: COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases; Psort location: cytoplasmic, score: 23 YP_001436683.1 COG: NOG14130 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001436684.1 This protein performs the mismatch recognition step during the DNA repair process YP_001436685.1 KEGG: bme:BMEII0002 1.9e-41 ribosomal-protein-serine acetyltransferase K00680; COG: COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins; Psort location: cytoplasmic, score: 23 YP_001436686.1 KEGG: ret:RHE_PF00265 4.1e-05 probable two-component sensor histidine kinase/response regulator hybrid protein; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 9 YP_001436687.1 Psort location: cytoplasmic, score: 23 YP_001436688.1 KEGG: bur:Bcep18194_A4695 1.5e-27 ABC polar amino acid transporter, periplasmic ligand binding protein K01713; COG: COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; Psort location: extracellular, including cell wall, score: 23 YP_001436689.1 KEGG: sma:SAV6546 5.7e-26 putative ABC transporter permease K02028; COG: COG0765 ABC-type amino acid transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001436690.1 KEGG: eca:ECA3539 5.7e-97 amino acid ABC transporter, ATP-binding protein K02028; COG: COG1126 ABC-type polar amino acid transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001436691.1 membrane-bound lytic murein transglycosylase B; catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan YP_001436692.1 COG: COG1546 Uncharacterized protein (competence- and mitomycin-induced); Psort location: cytoplasmic, score: 23 YP_001436693.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_001436694.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities YP_001436695.1 Psort location: cytoplasmic, score: 23 YP_001436696.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001436697.1 affects carbohydrate metabolism; has regulatory role in many processes YP_001436698.1 YqaB; catalyzes the dephosphorylation of fructose 1-phosphate, 6-phosphogluconate and p-nitrophenyl phosphate (pNPP); presents beta-phosphoglucomutase activity at a lower extent YP_001436699.1 COG: COG1238 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001436700.1 involved in the first step of glutathione biosynthesis YP_001436701.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2 YP_001436702.1 KEGG: shn:Shewana3_3829 2.4e-87 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) K01745; COG: COG2199 FOG: GGDEF domain; Psort location: endoplasmic reticulum, score: 9 YP_001436703.1 KEGG: sgl:SG1466 2.6e-06 dethiobiotinsynthase K01935; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001436704.1 COG: COG1566 Multidrug resistance efflux pump; Psort location: endoplasmic reticulum, score: 9 YP_001436705.1 DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; negative regulator of the multidrug operon emrAB YP_001436706.1 KEGG: shn:Shewana3_1692 5.5e-16 Xaa-His dipeptidase K01270; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001436707.1 with ProVW, part of the high-affinity transport system for the osmoprotectant glycine betaine YP_001436708.1 with ProVX is involved in the high-affinity uptake of glycine betaine YP_001436709.1 KEGG: ecc:c3230 7.3e-184 proV; glycine betaine/L-proline transport ATP-binding protein proV K02000; COG: COG4175 ABC-type proline/glycine betaine transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001436710.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE YP_001436711.1 Catalyzes the rate-limiting step in dNTP synthesis YP_001436712.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF YP_001436713.1 KEGG: eci:UTI89_C4152 0.0010 grxC; glutaredoxin 3 K03676; COG: COG0695 Glutaredoxin and related proteins; Psort location: nuclear, score: 23 YP_001436714.1 Psort location: mitochondrial, score: 23 YP_001436715.1 COG: COG4575 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001436716.1 COG: NOG09772 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001436717.1 COG: NOG11269 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001436718.1 Psort location: cytoplasmic, score: 23 YP_001436719.1 Psort location: mitochondrial, score: 23 YP_001436720.1 Psort location: cytoplasmic, score: 23 YP_001436721.1 COG: NOG35541 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001436722.1 KEGG: pae:PA1977 0.0015 sensor protein GLPS; COG: COG0401 Uncharacterized homolog of Blt101; Psort location: endoplasmic reticulum, score: 9 YP_001436723.1 KEGG: san:gbs1713 0.0044 similar to Glu-tRNA Gln amidotransferase subunit C K02435; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: extracellular, including cell wall, score: 9 YP_001436724.1 Psort location: mitochondrial, score: 23 YP_001436725.1 Psort location: cytoplasmic, score: 23 YP_001436726.1 COG: NOG27817 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001436727.1 COG: NOG11501 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001436728.1 KEGG: tth:TTC0552 0.0027 esterase; COG: COG0824 Predicted THIoesterase; Psort location: cytoplasmic, score: 23 YP_001436729.1 Psort location: cytoplasmic, score: 23 YP_001436730.1 KEGG: mbo:Mb2127 7.0e-55 helZ; probable helicase HelZ; COG: COG0553 Superfamily II DNA/RNA helicases, SNF2 family; Psort location: cytoplasmic, score: 23 YP_001436731.1 COG: NOG37979 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001436732.1 COG: NOG37734 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001436733.1 KEGG: rno:64012 2.0e-07 Rad50; RAD50 homolog (S. cerevisiae); COG: NOG19849 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001436734.1 KEGG: mma:MM0429 5.9e-237 type I restriction-modification system methylation subunit K03427; COG: COG0286 Type I restriction-modification system methyltransferase subunit; Psort location: cytoplasmic, score: 23 YP_001436735.1 KEGG: rba:RB11377 2.0e-54 hsdS; probable HsdS polypeptide, part of CfrA family K01154; COG: COG0732 Restriction endonuclease S subunits; Psort location: cytoplasmic, score: 23 YP_001436736.1 COG: NOG18152 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001436737.1 KEGG: mma:MM0431 0. type I restriction-modification system restriction subnit K01153; COG: COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases; Psort location: cytoplasmic, score: 23 YP_001436738.1 KEGG: hpa:HPAG1_0593 0.00080 ABC transporter, ATP-binding protein; COG: NOG08709 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001436739.1 Psort location: cytoplasmic, score: 23 YP_001436740.1 KEGG: sty:STY4832 1.4e-237 Bacteriophage P4 DNA primase; COG: COG4643 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001436741.1 COG: NOG29857 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001436742.1 Psort location: cytoplasmic, score: 23 YP_001436743.1 Psort location: cytoplasmic, score: 23 YP_001436744.1 COG: NOG20798 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001436745.1 COG: COG3311 Predicted transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001436746.1 COG: NOG23022 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001436747.1 COG: NOG23021 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001436748.1 COG: NOG36458 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001436749.1 COG: COG3950 Predicted ATP-binding protein involved in virulence; Psort location: nuclear, score: 23 YP_001436750.1 COG: COG0582 Integrase; Psort location: nuclear, score: 23 YP_001436751.1 Psort location: nuclear, score: 23 YP_001436752.1 COG: COG5295 Autotransporter adhesin; Psort location: cytoplasmic, score: 23 YP_001436753.1 COG: COG0845 Membrane-fusion protein; Psort location: cytoplasmic, score: 23 YP_001436754.1 COG: COG0691 tmRNA-binding protein; Psort location: mitochondrial, score: 23 YP_001436755.1 KEGG: tfu:Tfu_1222 1.5e-05 actinorhodin polyketide synthase bifunctional cyclase/dehydratase K05554; COG: COG2867 Oligoketide cyclase/lipid transport protein; Psort location: cytoplasmic, score: 23 YP_001436756.1 COG: COG2914 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001436757.1 COG: COG2913 Small protein A (tmRNA-binding); Psort location: extracellular, including cell wall, score: 9 YP_001436758.1 COG: COG0497 ATPase involved in DNA repair; Psort location: cytoplasmic, score: 23 YP_001436759.1 Psort location: endoplasmic reticulum, score: 9 YP_001436760.1 catalyzes the phosphorylation of NAD to NADP YP_001436761.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor YP_001436762.1 KEGG: ece:Z3906m 2.0e-188 yfjD; uncharacterized CBS domain-containing protein K00638; COG: COG4536 Putative Mg2+ and Co2+ transporter CorB; Psort location: endoplasmic reticulum, score: 23 YP_001436763.1 KEGG: sat:SYN_00150 3.9e-06 heme export protein apocytochrome heme-lyase; COG: COG4137 ABC-type uncharacterized transport system, permease component; Psort location: plasma membrane, score: 23 YP_001436764.1 with 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins YP_001436765.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_001436766.1 Essential for efficient processing of 16S rRNA YP_001436767.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_001436768.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_001436769.1 Psort location: cytoplasmic, score: 23 YP_001436770.1 COG: NOG22124 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001436771.1 KEGG: btk:BT9727_4489 3.4e-20 cysJ; sulfite reductase [NADPH], flavoprotein, alpha subunit K00379; COG: COG3182 Uncharacterized iron-regulated membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001436772.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive YP_001436773.1 catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis YP_001436774.1 KEGG: pub:SAR11_0777 7.3e-26 gnl; gluconolactonase K01053; COG: COG3386 Gluconolactonase; Psort location: cytoskeletal, score: 9 YP_001436775.1 catalyzing the formation of prephenate from chorismate and the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis YP_001436776.1 associated with 30S ribosomal subunit; interferes with translation elongation YP_001436777.1 COG: NOG23126 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001436778.1 with YaeT, NlpB and YfgL forms a complex involved in the proper assembly and/or targeting of OMPs to the outer membrane; involved in resistance to ampicillin and tetracycline YP_001436779.1 responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA YP_001436780.1 COG: COG1496 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001436781.1 KEGG: eci:UTI89_C2925 0. clpB; heat shock protein K03695; COG: COG0542 ATPases with chaperone activity, ATP-binding subunit; Psort location: cytoplasmic, score: 23 YP_001436784.1 COG: COG1763 Molybdopterin-guanine dinucleotide biosynthesis protein; Psort location: cytoplasmic, score: 23 YP_001436785.1 COG: NOG13395 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001436786.1 KEGG: bpm:BURPS1710b_0946 1.2e-204 poxB; pyruvate decarboxylase K00156; COG: COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Psort location: cytoplasmic, score: 23 YP_001436787.1 COG: NOG09993 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001436788.1 KEGG: cal:orf19.2425 0.0010 highly conserved hypothetical protein K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001436789.1 COG: COG5544 Predicted periplasmic lipoprotein; Psort location: extracellular, including cell wall, score: 9 YP_001436790.1 catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome YP_001436791.1 KEGG: eci:UTI89_C2907 0. yfiQ; hypothetical protein YfiQ K09181; COG: COG1042 Acyl-CoA synthetase (NDP forming); Psort location: cytoplasmic, score: 23 YP_001436792.1 COG: COG3148 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001436793.1 KEGG: sbo:SBO_2614 2.2e-63 trxC; putative THIoredoxin-like protein K03672; COG: COG0526 Thiol-disulfide isomerase and THIoredoxins; Psort location: cytoplasmic, score: 23 YP_001436794.1 KEGG: eci:UTI89_C2903 3.1e-144 yfiF; hypothetical tRNA/rRNA methyltransferase YfiF K03214; COG: COG0566 rRNA methylases; Psort location: cytoplasmic, score: 23 YP_001436795.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine YP_001436796.1 stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit YP_001436797.1 facilitates an early step in the assembly of the 50S subunit of the ribosome YP_001436798.1 KEGG: eci:UTI89_C2897 1.0e-97 yfiC; hypothetical protein YfiC K00599; COG: COG4123 Predicted O-methyltransferase; Psort location: mitochondrial, score: 23 YP_001436799.1 catalyzes the formation of oxaloacetate from L-aspartate YP_001436800.1 Psort location: cytoplasmic, score: 23 YP_001436801.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response YP_001436802.1 COG: COG3073 Negative regulator of sigma E activity; Psort location: nuclear, score: 23 YP_001436803.1 periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP YP_001436804.1 involved in the reduction of the SoxR iron-sulfur cluster YP_001436805.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_001436806.1 catalyzes the cleavage of the amino-terminal leader peptide from secretory proteins YP_001436807.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_001436808.1 COG: COG1381 Recombinational DNA repair protein (RecF pathway); Psort location: cytoplasmic, score: 23 YP_001436809.1 involved in the de novo synthesis of pyridoxine (Vitamin B6) YP_001436810.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids YP_001436811.1 KEGG: nar:Saro_2292 2.9e-06 NADH-quinone oxidoreductase, chain I K00338; COG: COG1145 Ferredoxin; Psort location: nuclear, score: 23 YP_001436812.1 KEGG: bte:BTH_I1550 1.5e-21 glucokinase/transcriptional regulator, RpiR family, fusion K00845; COG: COG1737 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001436813.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway YP_001436814.1 KEGG: sec:SC2565 1.7e-200 yfeV; putative phosphotransferase system IIB components K02809:K02810; COG: COG1264 Phosphotransferase system IIB components; Psort location: plasma membrane, score: 23 YP_001436815.1 COG: COG0560 Phosphoserine phosphatase; Psort location: cytoplasmic, score: 23 YP_001436816.1 KEGG: stt:t0289 5.8e-72 yfhC; hypothetical protein K01500; COG: COG0590 Cytosine/adenosine deaminases; Psort location: mitochondrial, score: 23 YP_001436817.1 YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function YP_001436818.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_001436819.1 KEGG: sec:SC2559 7.1e-186 yfhK; putative sensory kinase in regulatory system K07711; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 9 YP_001436820.1 COG: NOG06210 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001436821.1 KEGG: eci:UTI89_C2502 4.2e-85 atoC; acetoacetate metabolism regulatory protein AtoC K07714; COG: COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains; Psort location: cytoplasmic, score: 23 YP_001436822.1 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA YP_001436823.1 flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine YP_001436824.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_001436825.1 KEGG: vfi:VFA0114 1.1e-06 methyltransferase K00599; COG: COG0789 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001436826.1 KEGG: she:Shewmr4_0089 1.3e-42 carboxymuconolactone decarboxylase K01607; COG: COG0599 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit; Psort location: cytoplasmic, score: 23 YP_001436827.1 putative transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters YP_001436828.1 KEGG: spb:M28_Spy1064 7.6e-05 PTS system, mannitol (cryptic)-specific IIA component K00890; COG: COG3711 Transcriptional antiterminator; Psort location: cytoplasmic, score: 23 YP_001436829.1 COG: COG3683 ABC-type uncharacterized transport system, periplasmic component; Psort location: mitochondrial, score: 23 YP_001436830.1 COG: COG2215 ABC-type uncharacterized transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001436831.1 KEGG: spt:SPA0320 4.1e-126 suhB; extragenic suppressor protein SuhB K01092; COG: COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family; Psort location: cytoplasmic, score: 23 YP_001436832.1 KEGG: stm:STM2545 3.5e-113 putative rRNA methylase K02533; COG: COG0565 rRNA methylase; Psort location: cytoplasmic, score: 23 YP_001436833.1 regulates the expression of the iscRSUA operon YP_001436834.1 Psort location: cytoplasmic, score: 23 YP_001436835.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis YP_001436836.1 KEGG: rxy:Rxyl_1354 7.6e-16 tRNA (5-methylaminomethyl-2-THIouridylate)-methyltransferase K00566; COG: COG0822 NifU homolog involved in Fe-S cluster formation; Psort location: cytoplasmic, score: 23 YP_001436837.1 forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein YP_001436838.1 COG: COG1076 DnaJ-domain-containing proteins 1; Psort location: cytoplasmic, score: 23 YP_001436839.1 involved in the maturation of iron-sulfur cluster-containing proteins YP_001436840.1 KEGG: eci:UTI89_C2847 7.5e-56 fdx; ferredoxin, 2Fe-2S K04755; COG: COG0633 Ferredoxin; Psort location: cytoplasmic, score: 23 YP_001436841.1 COG: COG2975 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001436842.1 catalyzes the removal of an N-terminal amino acid from a peptide or arylamide YP_001436843.1 enhances serine sensitivity caused by inhibition of homoserine dehydrogenase I YP_001436844.1 KEGG: aci:ACIAD2833 7.6e-05 htpX; heat shock protein K03799; COG: COG0501 Zn-dependent protease with chaperone function; Psort location: endoplasmic reticulum, score: 9 YP_001436845.1 KEGG: aci:ACIAD2833 4.8e-10 htpX; heat shock protein K03799; COG: COG0501 Zn-dependent protease with chaperone function; Psort location: endoplasmic reticulum, score: 9 YP_001436846.1 KEGG: bte:BTH_I1550 4.8e-09 glucokinase/transcriptional regulator, RpiR family, fusion K00845; COG: COG1737 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001436847.1 catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds YP_001436848.1 KEGG: eca:ECA3226 4.0e-215 6-phospho-alpha-glucosidase K01232; COG: COG1486 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases; Psort location: cytoplasmic, score: 23 YP_001436849.1 KEGG: eca:ECA3225 8.9e-211 PTS system, alpha-glucoside-specific IIbc component K02790:K02791; COG: COG1264 Phosphotransferase system IIB components; Psort location: plasma membrane, score: 23 YP_001436850.1 COG: COG2373 Large extracellular alpha-helical protein; Psort location: extracellular, including cell wall, score: 9 YP_001436851.1 penicillin-insensitive transglycosylase/transpeptidase YP_001436852.1 Psort location: cytoplasmic, score: 23 YP_001436853.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate YP_001436854.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance YP_001436855.1 Psort location: mitochondrial, score: 23 YP_001436856.1 Psort location: mitochondrial, score: 23 YP_001436857.1 KEGG: ava:Ava_3308 0.00022 serine/threonine protein kinase K08884; COG: COG1426 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001436858.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis YP_001436859.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_001436860.1 COG: COG2976 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001436861.1 with YaeT, YfiO, and NlpB forms a complex involved in outer membrane protein biogenesis YP_001436862.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_001436863.1 KEGG: aha:AHA_1764 2.9e-15 ubiquitin ligase sinat5 K01932; COG: NOG17950 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001436864.1 COG: NOG18711 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001436865.1 KEGG: eca:ECA3211 1.8e-123 prt1; extracellular metalloprotease; COG: COG3227 Zinc metalloprotease (elastase); Psort location: cytoplasmic, score: 23 YP_001436866.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_001436867.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate YP_001436868.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_001436869.1 COG: NOG31354 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001436870.1 COG: NOG13900 non supervised orthologous group; Psort location: golgi, score: 9 YP_001436871.1 KEGG: vfi:VF0494 2.9e-25 sensory transduction protein kinase; COG: COG2199 FOG: GGDEF domain; Psort location: endoplasmic reticulum, score: 9 YP_001436872.1 KEGG: sty:STY2743 1.6e-236 ppx; exopolyphosphatase K01514; COG: COG0248 Exopolyphosphatase; Psort location: endoplasmic reticulum, score: 9 YP_001436873.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate YP_001436874.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate YP_001436875.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_001436876.1 KEGG: eci:UTI89_C2814 1.6e-101 upp; uracil phosphoribosyltransferase K00761; COG: COG0035 Uracil phosphoribosyltransferase; Psort location: cytoplasmic, score: 23 YP_001436877.1 KEGG: bcz:BCZK0244 3.6e-07 guanine-hypoxanTHIne permease; xanTHIne/uracil permease family protein K06901; COG: COG2233 XanTHIne/uracil permeases; Psort location: plasma membrane, score: 23 YP_001436878.1 controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP YP_001436879.1 KEGG: pha:PSHAa1133 3.8e-36 arsenate reductase; COG: COG1393 Arsenate reductase and related proteins, glutaredoxin family; Psort location: nuclear, score: 23 YP_001436880.1 KEGG: eci:UTI89_C2810 3.5e-216 yfgC; hypothetical protein YfgC precursor; COG: COG4783 Putative Zn-dependent protease, contains TPR repeats; Psort location: nuclear, score: 23 YP_001436881.1 KEGG: tbd:Tbd_2668 1.2e-28 phosphoribosylaminoimidazole-succinocarboxamide (SAICAR) synthetase K01923; COG: COG0628 Predicted permease; Psort location: plasma membrane, score: 23 YP_001436882.1 bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine YP_001436883.1 KEGG: eci:UTI89_C2806 5.5e-60 gcvR; glycine cleavage system transcriptional repressor K03567; COG: COG2716 Glycine cleavage system regulatory protein; Psort location: cytoplasmic, score: 23 YP_001436884.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_001436885.1 COG: COG3317 Uncharacterized lipoprotein; Psort location: nuclear, score: 23 YP_001436886.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_001436887.1 KEGG: eci:UTI89_C2802 1.8e-125 ypfJ; hypothetical protein; COG: COG2321 Predicted metalloprotease; Psort location: mitochondrial, score: 23 YP_001436888.1 KEGG: mes:Meso_0392 0.0014 GCN5-related N-acetyltransferase K03824; COG: COG1444 Predicted P-loop ATPase fused to an acetyltransferase; Psort location: cytoplasmic, score: 23 YP_001436889.1 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate YP_001436890.1 COG: NOG13899 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001436891.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica. YP_001436892.1 KEGG: eci:UTI89_C2797 2.0e-48 yffB; conserved THIoredoxin-like protein; COG: COG1393 Arsenate reductase and related proteins, glutaredoxin family; Psort location: cytoplasmic, score: 23 YP_001436893.1 KEGG: fnu:FN1006 2.6e-07 acetyltransferase K00680; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: cytoplasmic, score: 23 YP_001436894.1 KEGG: eci:UTI89_C2351 8.4e-112 yegO; hypothetical protein YegO K07789; COG: COG0841 Cation/multidrug efflux pump; Psort location: plasma membrane, score: 23 YP_001436895.1 nitrate/nitrite response regulator NarP; NarP is phosphorylated by NarX and NarQ and can activate fdnG and nitrite or nitrate reductase systems; represses expression of other anaerobic genes YP_001436896.1 KEGG: eci:UTI89_C2793 3.4e-76 yffH; hypothetical protein YffH K01515; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: cytoplasmic, score: 23 YP_001436897.1 COG: NOG06758 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001436898.1 Psort location: extracellular, including cell wall, score: 9 YP_001436899.1 Psort location: cytoplasmic, score: 23 YP_001436900.1 COG: NOG26784 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001436901.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase YP_001436902.1 KEGG: sty:STY2710 2.5e-142 talA; transaldolase A K00616; COG: COG0176 Transaldolase; Psort location: cytoplasmic, score: 23 YP_001436903.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate YP_001436904.1 KEGG: ecj:JW0580 1.1e-111 fepC; iron-enterobactin transporter subunit K02013; COG: COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components; Psort location: cytoplasmic, score: 23 YP_001436905.1 with FepBCD is involved in the transport of ferric enterobactin YP_001436906.1 with FepBCG is involved in the transport of ferric enterobactin YP_001436907.1 protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters YP_001436908.1 with FepCDG is involved in the transport of ferric enterobactin YP_001436909.1 KEGG: eco:b0593 1.4e-134 entC, fepF; isochorismate hydroxymutase 2, enterochelin biosynthesis K02361; COG: COG1169 Isochorismate synthase; Psort location: cytoplasmic, score: 23 YP_001436910.1 bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate YP_001436911.1 KEGG: ece:Z0737 5.3e-126 entB; 2,3-dihydro-2,3-dihydroxybenzoate synthetase, isochroismatase K01252; COG: COG3433 Aryl carrier domain; Psort location: cytoplasmic, score: 23 YP_001436912.1 catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin YP_001436913.1 KEGG: eco:b0597 7.8e-61 ybdB; hypothetical protein; COG: COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism; Psort location: cytoplasmic, score: 23 YP_001436914.1 KEGG: xtr:3283503 0.00072 ND6; NADH dehydrogenase subunit 6 K03884; COG: COG1966 Carbon starvation protein, predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001436915.1 COG: COG2879 Uncharacterized small protein; Psort location: cytoplasmic, score: 23 YP_001436916.1 COG: COG1396 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001436917.1 COG: COG2026 Cytotoxic translational repressor of toxin-antitoxin stability system; Psort location: cytoplasmic, score: 23 YP_001436918.1 KEGG: gme:Gmet_0086 2.5e-12 2-acyl-glycerophospho-ethanolamine acyltransferase K05939:K01909; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001436919.1 member of the iron-containing alcohol dehydrogenase family; unknown function YP_001436920.1 KEGG: eca:ECA2719 1.9e-185 ABC transporter, ATP-binding protein K02056; COG: COG1129 ABC-type sugar transport system, ATPase component; Psort location: extracellular, including cell wall, score: 9 YP_001436921.1 KEGG: msm:MSMEG_4171 4.8e-45 ribose transport system permease protein RbsC; COG: COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components; Psort location: plasma membrane, score: 23 YP_001436922.1 KEGG: bpm:BURPS1710b_A0023 2.4e-11 ABC transporter, ATP-binding protein domain protein K02056; COG: COG1879 ABC-type sugar transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001436923.1 COG: COG5276 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001436924.1 phosphorylates methylthioribose to form methylthioribose-1-phosphate; involved in methionine salvage pathway YP_001436925.1 KEGG: eca:ECA3477 6.7e-142 methylTHIoribose-1-phosphate isomerase K08963; COG: COG0182 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family; Psort location: endoplasmic reticulum, score: 9 YP_001436926.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis YP_001436927.1 KEGG: eci:UTI89_C2768 2.5e-128 amiA; probable N-acetylmuramoyl-L-alanine amidase AmiA precursor K01448; COG: COG0860 N-acetylmuramoyl-L-alanine amidase; Psort location: nuclear, score: 23 YP_001436928.1 Psort location: cytoplasmic, score: 23 YP_001436929.1 Psort location: cytoplasmic, score: 23 YP_001436930.1 KEGG: eco:b2434 1.6e-37 ypeA; putative acetyltransferase K00680; COG: COG0456 Acetyltransferases; Psort location: cytoplasmic, score: 23 YP_001436931.1 COG: COG3111 Uncharacterized conserved protein; Psort location: extracellular, including cell wall, score: 9 YP_001436932.1 Psort location: endoplasmic reticulum, score: 9 YP_001436933.1 COG: NOG06776 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001436934.1 KEGG: reh:H16_B0946 3.5e-42 predicted iron-dependent peroxidase K00430; COG: COG2837 Predicted iron-dependent peroxidase; Psort location: cytoplasmic, score: 23 YP_001436935.1 COG: COG4150 ABC-type sulfate transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001436936.1 KEGG: cyb:CYB_0398 3.0e-29 modB; molybdate ABC transporter, permease protein K02018; COG: COG0555 ABC-type sulfate transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001436937.1 Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import YP_001436938.1 KEGG: sdy:SDY_2618 1.1e-178 cysA; ATP-binding component of sulfate permease A protein K02045; COG: COG1118 ABC-type sulfate/molybdate transport systems, ATPase component; Psort location: cytoplasmic, score: 23 YP_001436939.1 catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide YP_001436940.1 COG: NOG10258 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001436941.1 functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose YP_001436942.1 Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system YP_001436943.1 KEGG: bci:BCI_0069 1.5e-32 ptsH; phosphocarrier protein HPr K00890; COG: COG1925 Phosphotransferase system, HPr-related proteins; Psort location: cytoplasmic, score: 23 YP_001436944.1 CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis YP_001436945.1 KEGG: ret:RHE_CH03674 2.8e-06 hypothetical protein K01954; COG: COG2981 Uncharacterized protein involved in cysteine biosynthesis; Psort location: endoplasmic reticulum, score: 23 YP_001436946.1 interacts with cell division protein FitsZ and may be required to anchor septal ring structure YP_001436947.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB YP_001436948.1 KEGG: cta:CTA_0585 0.00043 dnaQ_2; DNA polymerase III, epsilon chain K02342; COG: COG3530 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001436949.1 COG: NOG12169 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001436950.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_001436951.1 COG: NOG09771 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001436952.1 COG: NOG09771 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001436953.1 KEGG: shn:Shewana3_3829 8.8e-19 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) K01745; COG: COG2199 FOG: GGDEF domain; Psort location: endoplasmic reticulum, score: 9 YP_001436954.1 COG: COG1972 Nucleoside permease; Psort location: plasma membrane, score: 23 YP_001436955.1 COG: COG1914 Mn2+ and Fe2+ transporters of the NRAMP family; Psort location: plasma membrane, score: 23 YP_001436956.1 KEGG: ddi:DDB0219950 0.00013 helB2; putative RNA helicase K01529; COG: NOG09770 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001436957.1 KEGG: ret:RHE_CH02454 1.4e-109 probable oxidoreductase protein K05882; COG: COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001436958.1 KEGG: stm:STM2405 1.2e-188 indolepyruvate decarboxylase K01568; COG: COG3961 Pyruvate decarboxylase and related THIamine pyrophosphate-requiring enzymes; Psort location: cytoplasmic, score: 23 YP_001436959.1 catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate YP_001436960.1 KEGG: rru:Rru_A0376 3.0e-20 transcriptional regulator, LytR/AlgR family K07705; COG: COG3279 Response regulator of the LytR/AlgR family; Psort location: cytoplasmic, score: 23 YP_001436961.1 KEGG: ece:Z3645 1.1e-267 putative sensor protein K07704; COG: COG3275 Putative regulator of cell autolysis; Psort location: plasma membrane, score: 23 YP_001436962.1 COG: NOG06762 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001436963.1 KEGG: eco:b2379 5.5e-211 yfdZ; putative PLP-dependent aminotransferase; COG: COG0436 Aspartate/tyrosine/aromatic aminotransferase; Psort location: cytoplasmic, score: 23 YP_001436964.1 KEGG: sat:SYN_01359 2.1e-05 mannose-6-phosphate isomerase K01809; COG: COG0662 Mannose-6-phosphate isomerase; Psort location: cytoplasmic, score: 23 YP_001436965.1 COG: COG0598 Mg2+ and Co2+ transporters; Psort location: cytoplasmic, score: 23 YP_001436966.1 KEGG: shn:Shewana3_3435 2.2e-24 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001436967.1 KEGG: eca:ECA0740 2.4e-73 budA, aldC; alpha-acetolactate decarboxylase K01575; COG: COG3527 Alpha-acetolactate decarboxylase; Psort location: cytoplasmic, score: 23 YP_001436968.1 catalyzes the formation of 2-acetolactate from pyruvate in stationary phase YP_001436969.1 KEGG: eca:ECA0310 6.3e-107 budC; acetoin reductase K03366; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001436970.1 porin involved in osmoregulation allowing water to move into and out of the cell in response to osmotic pressure YP_001436971.1 Psort location: nuclear, score: 23 YP_001436972.1 Psort location: mitochondrial, score: 23 YP_001436973.1 KEGG: bcz:BCZK3485 8.0e-12 fdhC; formate transporter K00122; COG: COG2116 Formate/nitrite family of transporters; Psort location: plasma membrane, score: 23 YP_001436974.1 Psort location: cytoplasmic, score: 23 YP_001436975.1 ATP-binding protein; required for proper cytochrome c maturation YP_001436976.1 COG: COG2386 ABC-type transport system involved in cytochrome c biogenesis, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001436977.1 KEGG: vfi:VF1822 2.6e-85 heme chaperone heme-lyase K02195; COG: COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001436978.1 COG: COG3114 Heme exporter protein D; Psort location: cytoplasmic, score: 23 YP_001436979.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane YP_001436980.1 KEGG: vfi:VF1819 1.2e-229 heme chaperone--apocytochrome heme-lyase K02198; COG: COG1138 Cytochrome c biogenesis factor; Psort location: plasma membrane, score: 23 YP_001436981.1 KEGG: azo:azo3929 7.6e-31 ccmG; protein disulfide-isomerase K01829; COG: COG0526 Thiol-disulfide isomerase and THIoredoxins; Psort location: extracellular, including cell wall, score: 9 YP_001436982.1 KEGG: stm:STM4281 1.1e-19 nrfE; putative methylase K04016; COG: COG3088 Uncharacterized protein involved in biosynthesis of c-type cytochromes; Psort location: endoplasmic reticulum, score: 9 YP_001436983.1 COG: COG4235 Cytochrome c biogenesis factor; Psort location: endoplasmic reticulum, score: 9 YP_001436984.1 COG: COG2853 Surface lipoprotein; Psort location: extracellular, including cell wall, score: 9 YP_001436985.1 COG: COG2067 Long-chain fatty acid transport protein; Psort location: cytoplasmic, score: 23 YP_001436986.1 COG: COG3691 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001436987.1 FadI; fatty acid oxidation complex component beta; functions in a heterotetramer with FadJ; similar to FadA2B2 complex; functions in beta-oxidation of fatty acids during anaerobic growth YP_001436988.1 multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate YP_001436989.1 KEGG: sty:STY2619 2.7e-67 phosphohistidine phosphatase K08296; COG: COG2062 Phosphohistidine phosphatase SixA; Psort location: endoplasmic reticulum, score: 9 YP_001436990.1 COG: COG2840 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001436991.1 involved in methylation of ribosomal protein L3 YP_001436992.1 Psort location: endoplasmic reticulum, score: 9 YP_001436993.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_001436994.1 D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm YP_001436995.1 COG: COG0730 Predicted permeases; Psort location: endoplasmic reticulum, score: 9 YP_001436996.1 COG: COG3101 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001436997.1 COG: NOG13546 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001436998.1 catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules YP_001436999.1 FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_001437000.1 KEGG: pen:PSEEN3027 1.5e-48 serine protease PspB; COG: COG1404 Subtilisin-like serine proteases; Psort location: endoplasmic reticulum, score: 23 YP_001437001.1 in Salmonella typhimurium Flk regulates flagellar biosynthesis by inhibition of the flagellar-associated type III secretion system; lowers secretion levels of the anti-sigma28 factor FlgM to the periplasm; inner membrane-anchored protein YP_001437002.1 KEGG: sec:SC2372 3.0e-171 pdxB; erythronate-4-phosphate dehyrogenase K03473; COG: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Psort location: endoplasmic reticulum, score: 9 YP_001437003.1 KEGG: eci:UTI89_C2604 1.6e-149 usg; USG-1 protein K00133; COG: COG0136 Aspartate-semialdehyde dehydrogenase; Psort location: cytoplasmic, score: 23 YP_001437004.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_001437005.1 KEGG: lsl:LSL_1322 3.7e-15 alkaline phosphatase K01077; COG: COG0586 Uncharacterized membrane-associated protein; Psort location: endoplasmic reticulum, score: 9 YP_001437006.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits YP_001437007.1 KEGG: sty:STY2596 5.7e-177 folC; folylpolyglutamate synthase K01927:K01930; COG: COG0285 Folylpolyglutamate synthase; Psort location: cytoplasmic, score: 23 YP_001437008.1 KEGG: pfo:Pfl_1900 9.8e-09 argininosuccinate synthase K03749; COG: COG3147 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001437009.1 membrane protein required for colicin V production YP_001437010.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_001437011.1 catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate YP_001437012.1 KEGG: bur:Bcep18194_A4695 9.0e-28 ABC polar amino acid transporter, periplasmic ligand binding protein K01713; COG: COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; Psort location: extracellular, including cell wall, score: 9 YP_001437013.1 KEGG: bur:Bcep18194_A4695 1.3e-28 ABC polar amino acid transporter, periplasmic ligand binding protein K01713; COG: COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; Psort location: extracellular, including cell wall, score: 9 YP_001437014.1 Psort location: cytoplasmic, score: 23 YP_001437015.1 KEGG: sma:SAV6546 2.4e-20 putative ABC transporter permease K02028; COG: COG4215 ABC-type arginine transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001437016.1 KEGG: sma:SAV6546 3.6e-24 putative ABC transporter permease K02028; COG: COG4160 ABC-type arginine/histidine transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001437017.1 KEGG: sdy:SDY_2505 6.1e-125 hisP; ATP-binding component of histidine transport K02028; COG: COG4598 ABC-type histidine transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001437018.1 COG: NOG23433 non supervised orthologous group; Psort location: cytoskeletal, score: 9 YP_001437019.1 COG: NOG34653 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437020.1 KEGG: ava:Ava_0206 1.8e-52 hypothetical protein; COG: COG1090 Predicted nucleoside-diphosphate sugar epimerase; Psort location: cytoplasmic, score: 23 YP_001437021.1 KEGG: eci:UTI89_C2586 8.8e-85 yfcG; putative S-transferase K00799; COG: COG0625 glutathione S-transferase; Psort location: cytoplasmic, score: 23 YP_001437022.1 KEGG: eci:UTI89_C2585 9.1e-83 yfcF; hypothetical protein K00799; COG: COG0625 glutathione S-transferase; Psort location: cytoplasmic, score: 23 YP_001437023.1 KEGG: eci:UTI89_C2584 3.6e-72 yfcE; hypothetical protein; COG: COG0622 Predicted phosphoesterase; Psort location: cytoplasmic, score: 23 YP_001437024.1 KEGG: ssn:SSO_2356 2.1e-76 putative regulator; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: cytoplasmic, score: 23 YP_001437025.1 COG: COG1309 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001437026.1 KEGG: bcz:BCZK3497 4.0e-09 adaA; transcriptional regulator, AraC family K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: nuclear, score: 23 YP_001437027.1 COG: NOG15356 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001437028.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate YP_001437029.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA YP_001437030.1 COG: COG3092 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001437031.1 COG: COG3013 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001437032.1 KEGG: eci:UTI89_C2575 1.3e-81 yfbT; protein YfbT K01112; COG: COG0637 Predicted phosphatase/phosphohexomutase; Psort location: cytoplasmic, score: 23 YP_001437033.1 COG: COG0471 Di- and tricarboxylate transporters; Psort location: plasma membrane, score: 23 YP_001437034.1 KEGG: sdy:SDY_2487 2.4e-91 putative alpha helix protein K08722; COG: COG1896 Predicted hydrolases of HD superfamily; Psort location: mitochondrial, score: 23 YP_001437035.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor YP_001437036.1 KEGG: shn:Shewana3_3435 0.00059 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001437037.1 Psort location: cytoplasmic, score: 23 YP_001437038.1 Catalyzes the transfer of electrons from NADH to quinone YP_001437039.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen YP_001437040.1 NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms YP_001437041.1 Catalyzes the transfer of electrons from NADH to quinone YP_001437042.1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase YP_001437043.1 Catalyzes the transfer of electrons from NADH to quinone YP_001437044.1 Catalyzes the transfer of electrons from NADH to quinone YP_001437045.1 Catalyzes the transfer of electrons from NADH to quinone YP_001437046.1 Catalyzes the transfer of electrons from NADH to quinone YP_001437047.1 Catalyzes the transfer of electrons from NADH to quinone YP_001437048.1 Catalyzes the transfer of electrons from NADH to ubiquinone YP_001437049.1 Catalyzes the transfer of electrons from NADH to quinone YP_001437050.1 Catalyzes the transfer of electrons from NADH to quinone YP_001437051.1 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions YP_001437052.1 KEGG: vfi:VF0317 1.4e-31 acetyltransferase K02348; COG: COG2153 Predicted acyltransferase; Psort location: cytoplasmic, score: 23 YP_001437053.1 COG: COG4575 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001437054.1 KEGG: sec:SC2310 4.6e-111 menF; isochorismate synthase (isochorismate hydroxymutase 2), menaquinone biosynthesis K02552; COG: COG1169 Isochorismate synthase; Psort location: cytoplasmic, score: 23 YP_001437055.1 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis YP_001437056.1 KEGG: sbo:SBO_2300 1.7e-65 yfbB; putative enzyme K08680; COG: COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily); Psort location: cytoplasmic, score: 23 YP_001437057.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA YP_001437058.1 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate YP_001437059.1 KEGG: stt:t0558 1.5e-151 menE; O-succinylbenzoic acid-CoA ligase K01911; COG: COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II; Psort location: mitochondrial, score: 23 YP_001437060.1 COG: COG3647 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001437061.1 KEGG: mka:MK1013 0.00084 ntpK; archaeal/vacuolar-type H+-ATPase subunit K K02124; COG: COG3333 Uncharacterized protein conserved in bacteria; Psort location: plasma membrane, score: 23 YP_001437062.1 COG: NOG11450 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001437063.1 COG: COG3181 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001437064.1 KEGG: rha:RHA1_ro05622 3.8e-36 response regulator (protein-glutamate methylesterase) K07669; COG: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; Psort location: cytoplasmic, score: 23 YP_001437065.1 KEGG: stt:t2678 7.2e-161 tctE; putative two-component system sensor kinase K07649; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 9 YP_001437066.1 COG: NOG08732 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001437067.1 KEGG: hsa:80308 6.6e-08 FLAD1; FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae) K00953; COG: COG1058 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA; Psort location: cytoplasmic, score: 23 YP_001437068.1 Psort location: mitochondrial, score: 23 YP_001437069.1 catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell YP_001437070.1 hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic YP_001437071.1 plays a role in maintenance and possibly the biosynthesis of diferric-tyrosyl radical cofactor, essential for nucleotide reduction catalyzed by ribonucleotide reductases YP_001437072.1 B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA YP_001437073.1 Catalyzes the rate-limiting step in dNTP synthesis YP_001437074.1 Involved in ubiquinone biosynthesis YP_001437075.1 negatively supercoils closed circular double-stranded DNA YP_001437076.1 KEGG: sec:SC2274 0. rcsC; sensory histidine kinase in two-component regulatory system with RcsB, regulates colanic capsule biosynthesis K07677; COG: COG0784 FOG: CheY-like receiver; Psort location: endoplasmic reticulum, score: 9 YP_001437077.1 two-component response regulator RscB regulates the genes involved in capsule biosynthesis and cell division; probably phosphorylated by RcsC or RcsF YP_001437078.1 KEGG: stm:STM2269 0. yojN; putative sensor/kinase in regulatory system K07676; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 9 YP_001437079.1 allows for ions and hydrophilic solutes to cross the outer membrane YP_001437080.1 catalyzes the conversion of aminoimidazole ribotide to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine moiety of thiamine; involved in the maintenance and/or assembly of sulfur clusters; periplasmic lipoporotein anchored to the inner membrane; part of the thiamine pyrophosphate biosynthesis pathway YP_001437081.1 KEGG: ecc:c2754 7.5e-111 ada; ADA regulatory protein K00567; COG: COG0350 Methylated DNA-protein cysteine methyltransferase; Psort location: cytoplasmic, score: 23 YP_001437082.1 COG: COG3145 Alkylated DNA repair protein; Psort location: cytoplasmic, score: 23 YP_001437083.1 efflux pump for the antibacterial peptide microcin J25 YP_001437084.1 KEGG: hpa:HPAG1_0231 3.6e-63 putative sulfate permease K01672; COG: COG0659 Sulfate permease and related transporters (MFS superfamily); Psort location: plasma membrane, score: 23 YP_001437085.1 KEGG: ava:Ava_3150 8.3e-06 lysS; lysyl-tRNA synthetase K04567; COG: NOG22391 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437086.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: extracellular, including cell wall, score: 9 YP_001437087.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: golgi, score: 9 YP_001437088.1 KEGG: eci:UTI89_C4946 3.7e-08 putative member of ShlA/HecA/FhaA exoprotein family; COG: COG5295 Autotransporter adhesin; Psort location: cytoplasmic, score: 23 YP_001437089.1 Psort location: cytoplasmic, score: 23 YP_001437090.1 KEGG: chu:CHU_2528 5.0e-09 CHU large protein; uncharacterized K01238; COG: COG5295 Autotransporter adhesin; Psort location: cytoplasmic, score: 23 YP_001437091.1 KEGG: mxa:MXAN_3564 0.00017 peptidase, M36 (fungalysin) family K01423; COG: COG5295 Autotransporter adhesin; Psort location: cytoplasmic, score: 23 YP_001437092.1 KEGG: chu:CHU_2852 5.5e-31 CHU large protein; candidate b-glycosidase, glycoside hydrolase family 8 protein K01238; COG: COG5295 Autotransporter adhesin; Psort location: endoplasmic reticulum, score: 9 YP_001437093.1 Psort location: cytoplasmic, score: 23 YP_001437094.1 KEGG: shn:Shewana3_3435 0.0073 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001437095.1 COG: COG0582 Integrase; Psort location: nuclear, score: 23 YP_001437096.1 Psort location: cytoplasmic, score: 23 YP_001437097.1 KEGG: sbo:SBO_0976 1.4e-52 putative exodeoxyribonuclease VIII K01146; COG: NOG06785 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437098.1 Psort location: nuclear, score: 23 YP_001437099.1 Psort location: cytoplasmic, score: 23 YP_001437100.1 KEGG: spi:MGAS10750_Spy0587 5.4e-37 methyltransferase K00599; COG: NOG11045 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437101.1 Psort location: cytoplasmic, score: 23 YP_001437102.1 Psort location: cytoplasmic, score: 23 YP_001437103.1 COG: COG2974 DNA recombination-dependent growth factor C; Psort location: cytoplasmic, score: 23 YP_001437104.1 COG: NOG31115 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437105.1 Psort location: cytoplasmic, score: 23 YP_001437106.1 KEGG: chu:CHU_1313 9.2e-05 ligA; DNA ligase K01972; COG: NOG13955 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437107.1 KEGG: afu:AF2118 0.00021 guaB-2; IMP dehydrogenase K00088; COG: COG2932 Predicted transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001437108.1 COG: COG3381 Uncharacterized component of anaerobic dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001437109.1 COG: NOG27757 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437110.1 Psort location: cytoplasmic, score: 23 YP_001437111.1 COG: COG4626 Phage terminase-like protein, large subunit; Psort location: cytoplasmic, score: 23 YP_001437112.1 Psort location: cytoplasmic, score: 23 YP_001437113.1 COG: NOG18073 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001437114.1 Psort location: nuclear, score: 23 YP_001437115.1 KEGG: sac:SACOL0346 4.0e-13 prophage L54a, N-6-adenine-methyltransferase K00571; COG: NOG18143 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437116.1 KEGG: ece:Z5642 2.0e-14 lexA; regulator for SOS(LexA) regulon K01356; COG: COG1974 SOS-response transcriptional repressors (RecA-mediated autopeptidases); Psort location: nuclear, score: 23 YP_001437117.1 KEGG: eci:UTI89_C1478 2.8e-17 endodeoxyribonuclease RusA (Holliday junction resolvase) K01160; COG: COG4570 Holliday junction resolvase; Psort location: cytoplasmic, score: 23 YP_001437118.1 COG: COG3645 Uncharacterized phage-encoded protein; Psort location: cytoplasmic, score: 23 YP_001437119.1 Psort location: cytoplasmic, score: 23 YP_001437120.1 COG: NOG09845 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437121.1 COG: NOG18678 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001437122.1 COG: NOG37752 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001437123.1 COG: NOG23011 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437124.1 KEGG: cvi:CV0024 5.5e-07 probable hydroxyethylTHIazole kinase K00878; COG: COG3179 Predicted chitinase; Psort location: cytoplasmic, score: 23 YP_001437125.1 KEGG: ece:Z1798 6.8e-30 putative endopeptidase of prophage CP-933N K01423; COG: NOG19968 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437126.1 Psort location: nuclear, score: 23 YP_001437127.1 Psort location: cytoplasmic, score: 23 YP_001437128.1 Psort location: cytoplasmic, score: 23 YP_001437129.1 COG: COG3747 Phage terminase, small subunit; Psort location: cytoplasmic, score: 23 YP_001437130.1 COG: COG4626 Phage terminase-like protein, large subunit; Psort location: endoplasmic reticulum, score: 9 YP_001437131.1 COG: COG4695 Phage-related protein; Psort location: cytoplasmic, score: 23 YP_001437132.1 KEGG: nwi:Nwi_1543 1.4e-61 peptidase S14, ClpP K01358; COG: COG0740 Protease subunit of ATP-dependent Clp proteases; Psort location: endoplasmic reticulum, score: 23 YP_001437133.1 KEGG: rxy:Rxyl_1642 0.0065 ATP synthase F0, B subunit K02109; COG: NOG07926 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437134.1 Psort location: cytoplasmic, score: 23 YP_001437135.1 COG: NOG24115 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437136.1 COG: COG5614 Bacteriophage head-tail adaptor; Psort location: mitochondrial, score: 23 YP_001437137.1 Psort location: nuclear, score: 23 YP_001437138.1 Psort location: cytoplasmic, score: 23 YP_001437139.1 Psort location: nuclear, score: 23 YP_001437140.1 Psort location: cytoplasmic, score: 23 YP_001437141.1 Psort location: nuclear, score: 23 YP_001437142.1 KEGG: ddi:DDB0188427 0.0013 hypothetical protein K01778; Psort location: cytoplasmic, score: 23 YP_001437143.1 Psort location: endoplasmic reticulum, score: 9 YP_001437144.1 KEGG: eci:UTI89_C5128 1.3e-35 putative tail length tape measure protein precursor K00924; COG: COG5281 Phage-related minor tail protein; Psort location: cytoplasmic, score: 23 YP_001437145.1 COG: COG4718 Phage-related protein; Psort location: cytoplasmic, score: 23 YP_001437146.1 COG: COG4672 Phage-related protein; Psort location: cytoplasmic, score: 23 YP_001437147.1 COG: COG0791 Cell wall-associated hydrolases (invasion-associated proteins); Psort location: cytoplasmic, score: 23 YP_001437148.1 COG: COG4723 Phage-related protein, tail component; Psort location: endoplasmic reticulum, score: 9 YP_001437149.1 COG: COG4733 Phage-related protein, tail component; Psort location: cytoplasmic, score: 23 YP_001437150.1 Psort location: cytoplasmic, score: 23 YP_001437151.1 COG: COG5525 Bacteriophage tail assembly protein; Psort location: cytoplasmic, score: 23 YP_001437152.1 KEGG: aha:AHA_1664 4.1e-103 putative sulfatase; COG: COG3083 Predicted hydrolase of alkaline phosphatase superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001437153.1 COG: COG3082 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001437154.1 COG: COG3081 Nucleoid-associated protein; Psort location: cytoplasmic, score: 23 YP_001437155.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response YP_001437156.1 KEGG: eci:UTI89_C2461 1.8e-292 yejH; hypothetical protein YejH K01529; COG: COG1061 DNA or RNA helicases of superfamily II; Psort location: cytoplasmic, score: 23 YP_001437157.1 Psort location: cytoplasmic, score: 23 YP_001437158.1 catalyzes the synthesis pseudouridine from uracil-516 in 16S ribosomal RNA YP_001437159.1 Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance YP_001437160.1 Psort location: cytoplasmic, score: 23 YP_001437161.1 KEGG: pen:PSEEN3568 5.0e-153 ABC transporter, ATP-binding protein; COG: COG4172 ABC-type uncharacterized transport system, duplicated ATPase component; Psort location: cytoplasmic, score: 23 YP_001437162.1 COG: COG4239 ABC-type uncharacterized transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001437163.1 KEGG: syf:Synpcc7942_2454 1.0e-35 adenine phosphoribosyltransferase K00759; COG: COG4174 ABC-type uncharacterized transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001437164.1 COG: COG4166 ABC-type oligopeptide transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001437165.1 KEGG: vfi:VF0494 1.3e-37 sensory transduction protein kinase; COG: COG2200 FOG: EAL domain; Psort location: endoplasmic reticulum, score: 9 YP_001437166.1 by similarity, Spr seems to have peptidase activity; involved in thermoresistance YP_001437167.1 KEGG: eci:UTI89_C2451 2.8e-79 hypothetical protein K01094; COG: COG0671 Membrane-associated phospholipid phosphatase; Psort location: endoplasmic reticulum, score: 9 YP_001437168.1 KEGG: reh:H16_A3373 1.9e-17 putative GTPase (G3E family); COG: COG0523 Putative GTPases (G3E family); Psort location: mitochondrial, score: 23 YP_001437169.1 Psort location: cytoplasmic, score: 23 YP_001437170.1 KEGG: ecp:ECP_2213 5.2e-174 hypothetical oxidoreductase YeiQ; COG: COG0246 Mannitol-1-phosphate/altronate dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001437171.1 Psort location: cytoplasmic, score: 23 YP_001437172.1 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate YP_001437173.1 Stimulates the peptidyltransferase activity of the 70S ribosome and enhances dipeptide synthesis with N-formylmethionyl-tRNA and puromycin in vitro, suggesting its involvement in the formation of the first peptide bond of a protein YP_001437174.1 Psort location: cytoplasmic, score: 23 YP_001437175.1 Psort location: cytoplasmic, score: 23 YP_001437176.1 COG: COG0727 Predicted Fe-S-cluster oxidoreductase; Psort location: nuclear, score: 23 YP_001437177.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001437178.1 phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr YP_001437179.1 converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers YP_001437180.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_001437181.1 KEGG: reu:Reut_B5035 2.3e-70 4-hydroxyphenylpyruvate dioxygenase K00457; COG: COG1082 Sugar phosphate isomerases/epimerases; Psort location: cytoplasmic, score: 23 YP_001437182.1 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues YP_001437183.1 COG: COG2855 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001437184.1 Psort location: cytoplasmic, score: 23 YP_001437185.1 KEGG: shn:Shewana3_3435 1.9e-08 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001437186.1 KEGG: eci:UTI89_C0120 3.7e-70 aroP; aromatic amino acid transport protein AroP K03293; COG: COG0833 Amino acid transporters; Psort location: plasma membrane, score: 23 YP_001437187.1 KEGG: eco:b2154 6.0e-102 yeiG; putative esterase K03929; COG: COG0627 Predicted esterase; Psort location: cytoplasmic, score: 23 YP_001437188.1 KEGG: eci:UTI89_C5041 4.2e-30 yjiJ; hypothetical protein YjiJ K00403; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001437189.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer YP_001437190.1 COG: COG2311 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001437191.1 negative regulator of the mglBAC operon for galactose utilization YP_001437192.1 KEGG: msm:MSMEG_3095 2.4e-13 D-ribose-binding periplasmic protein; COG: COG1879 ABC-type sugar transport system, periplasmic component; Psort location: endoplasmic reticulum, score: 9 YP_001437193.1 with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains YP_001437194.1 ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex YP_001437195.1 COG: COG2949 Uncharacterized membrane protein; Psort location: extracellular, including cell wall, score: 9 YP_001437196.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis YP_001437197.1 KEGG: bcz:BCZK3376 3.7e-31 murein hydrolase export regulator K01238; COG: COG1346 Putative effector of murein hydrolase; Psort location: endoplasmic reticulum, score: 9 YP_001437198.1 KEGG: btk:BT9727_3424 2.1e-12 murein hydrolase exporter K06518; COG: COG1380 Putative effector of murein hydrolase LrgA; Psort location: endoplasmic reticulum, score: 9 YP_001437199.1 COG: COG4683 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001437200.1 Psort location: cytoplasmic, score: 23 YP_001437201.1 COG: NOG21794 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437202.1 KEGG: eca:ECA2799 9.3e-145 putative dihydrouridine synthase K05541; COG: COG0042 tRNA-dihydrouridine synthase; Psort location: cytoplasmic, score: 23 YP_001437203.1 KEGG: shn:Shewana3_3435 1.8e-08 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001437204.1 KEGG: cvi:CV0271 5.9e-79 mpd; methyl paraTHIon hydrolase; COG: COG0491 Zn-dependent hydrolases, including glyoxylases; Psort location: extracellular, including cell wall, score: 9 YP_001437205.1 KEGG: ecs:ECs3024 2.9e-102 oxidoreductase; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001437206.1 KEGG: bcl:ABC0731 3.2e-07 alkaline phosphatase K01077; COG: COG0586 Uncharacterized membrane-associated protein; Psort location: endoplasmic reticulum, score: 9 YP_001437207.1 COG: NOG06773 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001437208.1 specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7 YP_001437209.1 KEGG: bur:Bcep18194_B1154 4.9e-52 GCN5-related N-acetyltransferase K03823; COG: COG1247 Sortase and related acyltransferases; Psort location: cytoplasmic, score: 23 YP_001437210.1 component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent YP_001437211.1 KEGG: ecj:JW2120 0. bglX; beta-D-glucoside glucohydrolase, periplasmic K05349; COG: COG1472 Beta-glucosidase-related glycosidases; Psort location: cytoplasmic, score: 23 YP_001437212.1 KEGG: lwe:lwe1439 1.4e-22 glycine betaine/L-proline ABC transporter, permease/glycine betaine/L-proline-binding protein; COG: COG1732 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein); Psort location: extracellular, including cell wall, score: 9 YP_001437213.1 KEGG: lwe:lwe1439 7.4e-33 glycine betaine/L-proline ABC transporter, permease/glycine betaine/L-proline-binding protein; COG: COG1174 ABC-type proline/glycine betaine transport systems, permease component; Psort location: plasma membrane, score: 23 YP_001437214.1 KEGG: bur:Bcep18194_B0497 9.5e-72 ABC proline/glycine betaine transporter, ATPase subunit K05847; COG: COG1125 ABC-type proline/glycine betaine transport systems, ATPase components; Psort location: cytoplasmic, score: 23 YP_001437215.1 KEGG: lwe:lwe1439 5.7e-29 glycine betaine/L-proline ABC transporter, permease/glycine betaine/L-proline-binding protein; COG: COG1174 ABC-type proline/glycine betaine transport systems, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001437216.1 Psort location: mitochondrial, score: 23 YP_001437217.1 Psort location: cytoplasmic, score: 23 YP_001437218.1 KEGG: eci:UTI89_C3737 9.4e-10 yhdM; Zn(II)-responsive regulator of ZntA; COG: COG0789 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001437219.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_001437220.1 COG: COG1566 Multidrug resistance efflux pump; Psort location: golgi, score: 9 YP_001437221.1 COG: NOG14231 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001437222.1 KEGG: rru:Rru_A3236 6.4e-34 hypothetical protein K06020; COG: COG0577 ABC-type antimicrobial peptide transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001437223.1 KEGG: reh:H16_A1174 2.2e-33 ABC-type transporter, ATPase component: LPT family; COG: COG1136 ABC-type antimicrobial peptide transport system, ATPase component; Psort location: nuclear, score: 23 YP_001437224.1 Psort location: cytoplasmic, score: 23 YP_001437225.1 Psort location: extracellular, including cell wall, score: 9 YP_001437226.1 KEGG: eci:UTI89_C2387 7.3e-184 mrp; putative ATPase K03593; COG: COG0489 ATPases involved in chromosome partitioning; Psort location: cytoplasmic, score: 23 YP_001437227.1 KEGG: aha:AHA_3047 1.5e-11 acetyltransferase YjaB K00680; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: cytoplasmic, score: 23 YP_001437228.1 KEGG: stm:STM2159 3.8e-251 yehU; paral putative sensor/kinase in regulatory system K07704; COG: COG3275 Putative regulator of cell autolysis; Psort location: plasma membrane, score: 23 YP_001437229.1 unknown function; when overproduced it confers drug-resistance YP_001437230.1 KEGG: abo:ABO_1307 5.7e-06 sensor histidine kinase/respose regulator; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 9 YP_001437231.1 Psort location: endoplasmic reticulum, score: 9 YP_001437232.1 Psort location: endoplasmic reticulum, score: 9 YP_001437233.1 KEGG: bur:Bcep18194_C7259 2.2e-152 ABC transporter, duplicated ATPase domains; COG: COG0488 ATPase components of ABC transporters with duplicated ATPase domains; Psort location: cytoplasmic, score: 23 YP_001437234.1 COG: COG5455 Predicted integral membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001437235.1 Psort location: cytoplasmic, score: 23 YP_001437236.1 Psort location: extracellular, including cell wall, score: 9 YP_001437237.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP YP_001437238.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine YP_001437239.1 catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate YP_001437240.1 cytosolic protein with phosphatidylglycerol kinase activity; undetermined physiological role YP_001437241.1 KEGG: eci:UTI89_C2360 4.8e-235 yegQ; hypothetical protein K08303; COG: COG0826 Collagenase and related proteases; Psort location: cytoplasmic, score: 23 YP_001437242.1 response regulator in two-component regulatory system with BaeS; regulator of RNA synthesis, flagellar biosynthesis, chemotaxis and transport YP_001437243.1 KEGG: ssn:SSO_2130 7.0e-195 baeS; sensor protein (for BaeR) K07642; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 9 YP_001437244.1 KEGG: sgl:SG1466 6.1e-08 dethiobiotinsynthase K01935; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001437245.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC; confers resistance against novobiocin and deoxycholate YP_001437246.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate YP_001437247.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate YP_001437248.1 Psort location: cytoplasmic, score: 23 YP_001437249.1 COG: COG4683 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001437250.1 KEGG: afu:AF2118 0.0061 guaB-2; IMP dehydrogenase K00088; COG: NOG21794 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437251.1 KEGG: mbo:Mb0358 3.4e-09 dnaK; probable chaperone protein DnaK (heat shock protein 70) (heat shock 70 kda protein) (HSP70) K04043; COG: COG0443 Molecular chaperone; Psort location: cytoplasmic, score: 23 YP_001437252.1 inducible, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine YP_001437253.1 contains a MASE1 (Membrane-Associated Sensor) domain; potentially involved in signal transduction YP_001437254.1 Psort location: cytoplasmic, score: 23 YP_001437255.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor YP_001437256.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis YP_001437257.1 YegA; inner membrane protein involved in the assembly of outer membrane proteins (OMPs); asmA-null mutants show low lipopolysaccharide (LPS) levels, suggesting a role in LPS biogenesis and/or in restricting outer membrane fluidity, resulting on altered assembly of OMPs YP_001437258.1 KEGG: eci:UTI89_C0656 1.4e-25 ybeX; putative transport protein K06189; COG: COG1253 Hemolysins and related proteins containing CBS domains; Psort location: plasma membrane, score: 23 YP_001437259.1 COG: COG1596 Periplasmic protein involved in polysaccharide export; Psort location: mitochondrial, score: 23 YP_001437260.1 Wzb shows phosphatase activity towards the autophosphorylated Wzc protein, which induces colanic acid biosynthesis; catalyzes the phosphorylation of UDP-glucose dehydrogenase, an enzyme involved in colanic acid biosynthesis YP_001437261.1 Wzc; catalyzes the autophosphorylation on tyrosine residues which downregulates the biosynthesis of colonic acid (an extracellular polysaccharide) YP_001437262.1 KEGG: eci:UTI89_C2333 2.7e-129 wcaA; putative colanic acid biosynthesis glycosyltransferase WcaA; COG: COG0463 Glycosyltransferases involved in cell wall biogenesis; Psort location: mitochondrial, score: 23 YP_001437263.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); wcaB is induced in sessile bacteria and by osmotic shock, and repressed when grown in rich medium YP_001437264.1 KEGG: eci:UTI89_C2331 3.0e-178 wcaC; putative glycosyltransferase K00754; COG: COG0438 Glycosyltransferase; Psort location: cytoplasmic, score: 23 YP_001437265.1 essential for colanic acid biosynthesis; colanic acid is an exopolysaccharide produced under stress conditions that confers acid and heat tolerance YP_001437266.1 KEGG: eci:UTI89_C2329 7.1e-99 wcaE; putative colanic acid biosynthesis glycosyl transferase; COG: COG0463 Glycosyltransferases involved in cell wall biogenesis; Psort location: cytoplasmic, score: 23 YP_001437267.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit) YP_001437268.1 KEGG: ecc:c2579 1.6e-195 gmd; GDP-mannose 4,6-dehydratase K01711; COG: COG1089 GDP-D-mannose dehydratase; Psort location: cytoplasmic, score: 23 YP_001437269.1 KEGG: ecc:c2578 2.0e-156 wcaG; GDP-fucose synthetase K02377; COG: COG0451 Nucleoside-diphosphate-sugar epimerases; Psort location: cytoplasmic, score: 23 YP_001437270.1 KEGG: sfl:SF2114 6.6e-64 wcaH; GDP-mannose mannosyl hydrolase K03207; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: cytoplasmic, score: 23 YP_001437271.1 KEGG: eci:UTI89_C2324 1.2e-183 wcaI; putative colanic biosynthesis glycosyl transferase K03208; COG: COG0438 Glycosyltransferase; Psort location: cytoplasmic, score: 23 YP_001437272.1 KEGG: ecc:c2575 7.8e-235 cpsB; mannose-1-phosphate guanylyltransferase K00971; COG: COG0662 Mannose-6-phosphate isomerase; Psort location: cytoplasmic, score: 23 YP_001437273.1 KEGG: ecc:c2573 9.4e-223 cpsG; phosphomannomutase K01840; COG: COG1109 Phosphomannomutase; Psort location: cytoplasmic, score: 23 YP_001437274.1 WcaJ; glucose-1-phosphate transferase responsible for the addition of the first glucose-1-phosphate from UDP-glucose to the lipid carrier undecaprenyl phosphate in the biosynthesis of colanic acid YP_001437275.1 COG: COG2244 Membrane protein involved in the export of O-antigen and teichoic acid; Psort location: plasma membrane, score: 23 YP_001437276.1 KEGG: sbo:SBO_0872 6.7e-190 wcaK; putative galactokinase K00849; COG: COG2327 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001437277.1 KEGG: eco:b2044 4.2e-165 wcaL, yefL; putative colanic acid biosynthesis glycosyl transferase; COG: COG0438 Glycosyltransferase; Psort location: cytoplasmic, score: 23 YP_001437278.1 WcaM from Salmonella enterica is essential for biofilm formation on HEp-2 cells and chicken intestinal tissue but not on a plastic surface; may be involved in the biosynthesis of colanic acid YP_001437279.1 KEGG: sat:SYN_02668 7.5e-24 UDP-glucose 4-epimerase K01784; COG: COG0451 Nucleoside-diphosphate-sugar epimerases; Psort location: cytoplasmic, score: 23 YP_001437280.1 together with GalU subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose YP_001437281.1 NAD(P) binding; catalyzes the formation of dTDP-4-dehydro-6-deoxy-D-glucose from dTDP-glucose YP_001437282.1 KEGG: nme:NMB0062 6.2e-116 glucose-1-phosphate thymidylyltransferase K00973; COG: COG1209 dTDP-glucose pyrophosphorylase; Psort location: endoplasmic reticulum, score: 23 YP_001437283.1 KEGG: btl:BALH_2628 7.5e-08 acetyltransferase, GNAT family K00680; COG: COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins; Psort location: cytoplasmic, score: 23 YP_001437284.1 Psort location: cytoplasmic, score: 23 YP_001437285.1 KEGG: ava:Ava_0899 9.8e-54 Cys/Met metabolism pyridoxal-phosphate-dependent enzyme K00811; COG: COG0399 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis; Psort location: cytoplasmic, score: 23 YP_001437286.1 COG: COG2244 Membrane protein involved in the export of O-antigen and teichoic acid; Psort location: endoplasmic reticulum, score: 23 YP_001437287.1 KEGG: mma:MM1141 1.5e-14 glycosyltransferase K00754; COG: COG0463 Glycosyltransferases involved in cell wall biogenesis; Psort location: cytoplasmic, score: 23 YP_001437288.1 Psort location: plasma membrane, score: 23 YP_001437289.1 Psort location: endoplasmic reticulum, score: 9 YP_001437290.1 Psort location: nuclear, score: 23 YP_001437291.1 KEGG: aha:AHA_2883 1.1e-54 glycosyl transferase, group 2 family protein K00754; COG: COG0463 Glycosyltransferases involved in cell wall biogenesis; Psort location: nuclear, score: 23 YP_001437292.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate YP_001437293.1 KEGG: pfo:Pfl_3844 0.00010 lipopolysaccharide biosynthesis K00903; COG: COG3765 Chain length determinant protein; Psort location: plasma membrane, score: 23 YP_001437294.1 KEGG: sdy:SDY_2215 8.3e-89 hisI; phosphoribosyl-amp cyclohydrolase K01496:K01523; COG: COG0139 Phosphoribosyl-AMP cyclohydrolase; Psort location: cytoplasmic, score: 23 YP_001437295.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase YP_001437296.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide YP_001437297.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide YP_001437298.1 catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate YP_001437299.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_001437300.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_001437301.1 KEGG: eca:ECA2582 5.7e-74 hisG; ATP phosphoribosyltransferase K00765; COG: COG0040 ATP phosphoribosyltransferase; Psort location: cytoplasmic, score: 23 YP_001437302.1 Psort location: cytoplasmic, score: 23 YP_001437303.1 Psort location: cytoplasmic, score: 23 YP_001437304.1 KEGG: eba:ebA1635 2.8e-08 galE1; hypothetical protein K01784; COG: COG0451 Nucleoside-diphosphate-sugar epimerases; Psort location: extracellular, including cell wall, score: 9 YP_001437305.1 KEGG: cvi:CV2023 7.3e-42 probable amidophosphoribosyltransferase K00764; COG: COG2071 Predicted glutamine amidotransferases; Psort location: extracellular, including cell wall, score: 9 YP_001437306.1 Psort location: nuclear, score: 23 YP_001437307.1 KEGG: aha:AHA_3002 6.7e-158 gabT; 4-aminobutyrate transaminase K00823; COG: COG0160 4-aminobutyrate aminotransferase and related aminotransferases; Psort location: extracellular, including cell wall, score: 23 YP_001437308.1 KEGG: eci:UTI89_C0120 1.3e-12 aroP; aromatic amino acid transport protein AroP K03293; COG: COG0531 Amino acid transporters; Psort location: plasma membrane, score: 23 YP_001437309.1 Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates YP_001437310.1 KEGG: mtu:Rv0517 1.0e-13 possible membrane acyltransferase K00680; COG: COG1835 Predicted acyltransferases; Psort location: plasma membrane, score: 23 YP_001437311.1 removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; penicillin-binding protein 6B; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains YP_001437312.1 COG: COG3449 DNA gyrase inhibitor; Psort location: cytoplasmic, score: 23 YP_001437313.1 Psort location: cytoplasmic, score: 23 YP_001437314.1 COG: COG1289 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001437315.1 KEGG: bba:Bd3749 0.0024 lon; ATP-dependent protease La K01338; COG: COG2926 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001437316.1 KEGG: rxy:Rxyl_3145 0.0054 NADH dehydrogenase (quinone) K05903; COG: COG0534 Na+-driven multidrug efflux pump; Psort location: plasma membrane, score: 23 YP_001437317.1 COG: COG3501 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001437318.1 COG: NOG18468 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 23 YP_001437319.1 COG: NOG18467 non supervised orthologous group; Psort location: cytoskeletal, score: 9 YP_001437320.1 COG: NOG18467 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437321.1 Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile YP_001437322.1 KEGG: shn:Shewana3_3829 1.5e-14 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) K01745; COG: COG2200 FOG: EAL domain; Psort location: cytoplasmic, score: 23 YP_001437323.1 KEGG: ret:RHE_CH02675 6.9e-156 probable alkanal monooxygenase (bacterial liciferase alpha chain) like protein K00494; COG: COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases; Psort location: cytoplasmic, score: 23 YP_001437324.1 Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation YP_001437325.1 LysR-type transcriptional regulator similar to CysB; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates two operons consisting of ABC transporters that are part of the cys regulon; regulated by CysB YP_001437326.1 KEGG: cal:orf19.5753 0.0050 STL1; sugar transporter K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001437327.1 COG: COG3228 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001437328.1 KEGG: ava:Ava_3170 2.4e-34 putative diguanylate cyclase (GGDEF domain) K02488; COG: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; Psort location: endoplasmic reticulum, score: 9 YP_001437329.1 KEGG: shn:Shewana3_3435 4.2e-07 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: extracellular, including cell wall, score: 9 YP_001437330.1 KEGG: ret:RHE_PF00538 2.2e-24 hypothetical protein K01423; COG: COG0693 Putative intracellular protease/amidase; Psort location: extracellular, including cell wall, score: 9 YP_001437331.1 KEGG: chu:CHU_1425 3.8e-68 fabG; 3-oxoacyl-[acyl-carrier-protein] reductase K00059; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001437332.1 COG: NOG15335 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437333.1 COG: COG3203 Outer membrane protein (porin); Psort location: extracellular, including cell wall, score: 9 YP_001437334.1 COG: COG1418 Predicted HD superfamily hydrolase; Psort location: cytoplasmic, score: 23 YP_001437335.1 KEGG: stm:STM1992 5.1e-192 dcm; DNA cytosine methylase K00558; COG: COG0270 Site-specific DNA methylase; Psort location: cytoplasmic, score: 23 YP_001437336.1 KEGG: eci:UTI89_C2161 2.7e-67 vsr; DNA mismatch endonuclease, patch repair protein K07458; COG: COG3727 DNA G:T-mismatch repair endonuclease; Psort location: cytoplasmic, score: 23 YP_001437337.1 KEGG: pae:PA1977 0.0056 sensor protein GLPS; COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: plasma membrane, score: 23 YP_001437338.1 KEGG: sru:SRU_1714 0.0086 cdsA; phosphatidate cytidylyltransferase K00981; COG: COG2354 Uncharacterized protein conserved in bacteria; Psort location: plasma membrane, score: 23 YP_001437339.1 COG: COG5475 Uncharacterized small protein; Psort location: cytoplasmic, score: 23 YP_001437340.1 Psort location: cytoplasmic, score: 23 YP_001437341.1 KEGG: aha:AHA_1274 3.4e-24 response regulator PleD (stalked cell differentiation-controllingprotein) K05345; COG: COG2199 FOG: GGDEF domain; Psort location: endoplasmic reticulum, score: 23 YP_001437342.1 catalyzes the hydrolysis of mannosyl-3-phosphoglycerate to form the osmolyte mannosylglycerate YP_001437343.1 Psort location: nuclear, score: 23 YP_001437344.1 COG: NOG14105 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001437345.1 COG: COG2771 DNA-binding HTH domain-containing proteins; Psort location: nuclear, score: 23 YP_001437346.1 FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus YP_001437347.1 with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus YP_001437348.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus YP_001437349.1 with FlhA, FlhB, FliP, FliQ and FliR is one of the membrane components of the flagellar export apparatus YP_001437350.1 One of three proteins involved in switching the direction of the flagellar rotation YP_001437351.1 with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation YP_001437352.1 interacts with cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring YP_001437353.1 KEGG: rno:79011 0.0015 Camkv; CaM kinase-like vesicle-associated K08812; COG: COG3144 Flagellar hook-length control protein; Psort location: nuclear, score: 23 YP_001437354.1 rod/hook and filament chaperone YP_001437355.1 involved in type III protein export during flagellum assembly YP_001437356.1 binds to and inhibits the function of flagella specific ATPase FliI YP_001437357.1 One of three proteins involved in switching the direction of the flagellar rotation YP_001437358.1 the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod YP_001437359.1 COG: COG1677 Flagellar hook-basal body protein; Psort location: cytoplasmic, score: 23 YP_001437360.1 KEGG: ecc:c1631 1.5e-11 umuD; umuD protein K03503; COG: COG1974 SOS-response transcriptional repressors (RecA-mediated autopeptidases); Psort location: cytoplasmic, score: 23 YP_001437361.1 KEGG: eci:UTI89_C1370 2.6e-156 umuC; UmuC protein K03502; COG: COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair; Psort location: cytoplasmic, score: 23 YP_001437362.1 Psort location: cytoplasmic, score: 23 YP_001437363.1 COG: COG0582 Integrase; Psort location: mitochondrial, score: 23 YP_001437364.1 Psort location: nuclear, score: 23 YP_001437365.1 Psort location: extracellular, including cell wall, score: 23 YP_001437366.1 Psort location: cytoplasmic, score: 23 YP_001437367.1 COG: NOG22465 non supervised orthologous group; Psort location: vacuolar, score: 9 YP_001437368.1 Psort location: cytoplasmic, score: 23 YP_001437369.1 COG: COG4316 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001437370.1 KEGG: eci:UTI89_C1370 2.2e-22 umuC; UmuC protein K03502; COG: COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair; Psort location: cytoplasmic, score: 23 YP_001437371.1 COG: COG1396 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001437372.1 KEGG: lpl:lp_3108 1.4e-38 oxidoreductase (putative); COG: COG0451 Nucleoside-diphosphate-sugar epimerases; Psort location: mitochondrial, score: 23 YP_001437373.1 KEGG: eci:UTI89_C0735 0.0020 tolA; membrane spanning protein TolA K03646; COG: COG3652 Predicted outer membrane protein; Psort location: extracellular, including cell wall, score: 9 YP_001437374.1 KEGG: eci:UTI89_C5041 9.4e-07 yjiJ; hypothetical protein YjiJ K00403; COG: COG2814 Arabinose efflux permease; Psort location: endoplasmic reticulum, score: 9 YP_001437375.1 Psort location: cytoplasmic, score: 23 YP_001437376.1 KEGG: shn:Shewana3_3435 4.4e-07 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001437377.1 KEGG: aci:ACIAD0539 4.6e-40 putative methyltransferase; COG: COG0500 SAM-dependent methyltransferases; Psort location: cytoplasmic, score: 23 YP_001437378.1 Psort location: endoplasmic reticulum, score: 9 YP_001437379.1 COG: COG2135 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001437380.1 COG: COG0425 Predicted redox protein, regulator of disulfide bond formation; Psort location: nuclear, score: 23 YP_001437381.1 COG: COG2391 Predicted transporter component; Psort location: endoplasmic reticulum, score: 9 YP_001437382.1 COG: NOG09020 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001437383.1 binds flagellar cap subunits (FliD) and seems to prevents their oligomerization prior to its translocation through the flagellum-specific type III export pathway; acts as a repressor of flagellar class 2 operons by preventing FlhD2C2 to bind the promoter and inhibiting the FlhD2C2-dependent transcription; member of the type III cytoplasmic chaperone family YP_001437384.1 flagellin specific chaperone YP_001437385.1 KEGG: cal:orf19.7586 1.5e-07 CHT3; chitinase 3 precursor K01183; COG: COG1345 Flagellar capping protein; Psort location: nuclear, score: 23 YP_001437386.1 COG: COG1344 Flagellin and related hook-associated proteins; Psort location: nuclear, score: 23 YP_001437387.1 COG: COG0500 SAM-dependent methyltransferases; Psort location: endoplasmic reticulum, score: 9 YP_001437388.1 KEGG: mmu:108155 8.3e-30 Ogt; O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) K00754; COG: COG3914 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family; Psort location: cytoplasmic, score: 23 YP_001437389.1 KEGG: psp:PSPPH_3420 4.2e-133 aminotransferase, DegT/DnrJ/EryC1/StrS family K01726; COG: COG0399 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis; Psort location: cytoplasmic, score: 23 YP_001437390.1 KEGG: rso:RS02341 2.3e-22 RSp1007; putative acetyl transferase protein K00680; COG: COG2148 Sugar transferases involved in lipopolysaccharide synthesis; Psort location: cytoplasmic, score: 23 YP_001437391.1 Psort location: cytoplasmic, score: 23 YP_001437392.1 KEGG: lic:LIC20064 1.5e-41 fabG; 3-oxoacyl-(acyl-carrier protein) reductase K00059; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: endoplasmic reticulum, score: 9 YP_001437393.1 KEGG: mxa:MXAN_4770 1.1e-38 fabG; 3-oxoacyl-(acyl-carrier-protein) reductase K00059; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001437394.1 Psort location: cytoplasmic, score: 23 YP_001437395.1 KEGG: gka:GK0668 2.6e-32 long-chain fatty-acid-CoA ligase K01897; COG: COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II; Psort location: cytoplasmic, score: 23 YP_001437396.1 KEGG: cvi:CV4318 3.6e-19 luxE; long-chain-fatty-acid--luciferin-component ligase, acyl-protein synthase; COG: NOG06256 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437397.1 KEGG: vfi:VFA0923 1.3e-05 LuxC, acyl-CoA reductase; COG: NOG18388 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437398.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes YP_001437399.1 expression activator of the class 2 type of flagellar operons, essential to achieve maximal cell motility; activator of type 1 fimbrial gene expression; cell density-responsive regulator; FliZ in Salmonella typhimurium induces HilA, an activator of invasion genes necessary to achieve full virulence YP_001437400.1 KEGG: eci:UTI89_C2121 1.3e-122 fliY; cystine-binding periplasmic protein precursor K02030:K02424; COG: COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; Psort location: extracellular, including cell wall, score: 9 YP_001437401.1 Psort location: cytoplasmic, score: 23 YP_001437402.1 catalyzes the formation of pyruvate from D-cysteine YP_001437403.1 KEGG: hpa:HPAG1_0922 5.1e-41 amino acid ABC transporter, permease protein; COG: COG0765 ABC-type amino acid transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001437404.1 KEGG: ecj:JW1902 1.2e-114 yecC; predicted transporter subunit K02028; COG: COG1126 ABC-type polar amino acid transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001437405.1 regulates genes involved in cell division YP_001437406.1 COG: NOG13894 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001437407.1 in Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system; in Salmonella SirA and BarA regulate virulence gene expression also via the Csr system YP_001437408.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_001437409.1 KEGG: stt:t0931 1.6e-85 pgsA; phosphotidylglycerophosphate synthetase K00995; COG: COG0558 Phosphatidylglycerophosphate synthase; Psort location: endoplasmic reticulum, score: 9 YP_001437411.1 Psort location: cytoplasmic, score: 23 YP_001437412.1 KEGG: btk:BT9727_2565 4.1e-23 acetyltransferase, GNAT family K00680; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: mitochondrial, score: 23 YP_001437413.1 COG: COG0814 Amino acid permeases; Psort location: endoplasmic reticulum, score: 9 YP_001437414.1 cytoplasmic iron storage protein YP_001437415.1 Psort location: nuclear, score: 23 YP_001437416.1 COG: NOG11332 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001437417.1 KEGG: vpa:VPA0675 0.0079 torS; sensor protein TorS K07647; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 9 YP_001437418.1 KEGG: stm:STM1933 6.0e-102 hypothetical protein K01806; COG: COG0698 Ribose 5-phosphate isomerase RpiB; Psort location: cytoplasmic, score: 23 YP_001437419.1 KEGG: ani:AN1180.2 3.2e-07 hypothetical protein K04428; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001437420.1 COG: NOG15359 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437421.1 COG: COG1280 Putative threonine efflux protein; Psort location: endoplasmic reticulum, score: 9 YP_001437422.1 KEGG: bha:BH0394 8.8e-09 adaA; methylphosphotriester-DNA alkyltransferase (AraC/XylS family) K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001437423.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters YP_001437424.1 COG: COG1528 Ferritin-like protein; Psort location: cytoplasmic, score: 23 YP_001437425.1 COG: COG4297 Uncharacterized protein containing double-stranded beta helix domain; Psort location: cytoplasmic, score: 23 YP_001437426.1 KEGG: aha:AHA_1903 6.0e-141 L-arabinose ABC transporter, periplasmic L-arabinose-binding protein; COG: COG1879 ABC-type sugar transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001437427.1 Psort location: endoplasmic reticulum, score: 9 YP_001437428.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose YP_001437429.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose YP_001437430.1 biosynthetic; catalyzes the formation of trehalose and phosphate from trehalose-6-phosphate; expression is increased under osmotic stress and induced during the transition to stationary phase and by decreased temperature YP_001437431.1 KEGG: ssn:SSO_1221 3.3e-220 otsA; trehalose-6-phosphate synthase K00697; COG: COG0380 Trehalose-6-phosphate synthase; Psort location: cytoplasmic, score: 23 YP_001437432.1 ppGpp-dependent; membrane-associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress YP_001437433.1 with FlhC is involved in the activation of class 2 flagellar genes and is involved in the regulation of a number of other genetic systems YP_001437434.1 With FlhD is involved in the activation of class 2 flagellar genes and as well as a number of other genetic systems YP_001437435.1 With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine YP_001437436.1 with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine YP_001437437.1 chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY; sensory histidine kinase/signal sensing protein; CheA is the histidine kinase component YP_001437438.1 KEGG: eci:UTI89_C2090 2.1e-74 cheW; CheW positive regulator of CheA protein activity K03408; COG: COG0835 Chemotaxis signal transduction protein; Psort location: cytoplasmic, score: 23 YP_001437439.1 KEGG: chu:CHU_0838 0.0026 CHU large protein; uncharacterized K01238; COG: COG5430 Uncharacterized secreted protein; Psort location: mitochondrial, score: 23 YP_001437440.1 COG: COG5430 Uncharacterized secreted protein; Psort location: mitochondrial, score: 23 YP_001437441.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: cytoplasmic, score: 23 YP_001437442.1 COG: COG3188 P pilus assembly protein, porin PapC; Psort location: extracellular, including cell wall, score: 9 YP_001437443.1 COG: COG5430 Uncharacterized secreted protein; Psort location: extracellular, including cell wall, score: 9 YP_001437444.1 KEGG: vpa:VPA0675 5.0e-06 torS; sensor protein TorS K07647; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 9 YP_001437445.1 Psort location: nuclear, score: 23 YP_001437446.1 methylates the MCP YP_001437447.1 regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins YP_001437448.1 chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble YP_001437449.1 cytosolic phosphatase which functions in the chemotaxis signal transduction complex by controlling the level of phosphorylated CheY through dephosphorylation YP_001437450.1 COG: COG1377 Flagellar biosynthesis pathway, component FlhB; Psort location: endoplasmic reticulum, score: 9 YP_001437451.1 membrane protein involved in the flagellar export apparatus YP_001437452.1 COG: NOG12148 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001437453.1 KEGG: eci:UTI89_C4210 3.4e-16 yicJ; hypothetical symporter YicJ K03292; COG: COG2211 Na+/melibiose symporter and related transporters; Psort location: plasma membrane, score: 23 YP_001437454.1 COG: COG4225 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins; Psort location: cytoplasmic, score: 23 YP_001437455.1 COG: NOG06782 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437456.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_001437457.1 COG: COG3102 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001437458.1 COG: COG5637 Predicted integral membrane protein; Psort location: cytoplasmic, score: 23 YP_001437459.1 KEGG: ava:Ava_C0165 4.0e-128 zinc-containing alcohol dehydrogenase superfamily; COG: COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001437460.1 KEGG: dar:Daro_4129 3.8e-84 aminotransferase, class I and II K00842; COG: COG1168 Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities; Psort location: cytoplasmic, score: 23 YP_001437461.1 KEGG: cef:CE1276 0.0077 putative arginyl-tRNA synthetase K01887; COG: COG3142 Uncharacterized protein involved in copper resistance; Psort location: cytoplasmic, score: 23 YP_001437462.1 Psort location: cytoplasmic, score: 23 YP_001437463.1 KEGG: mbo:Mb0358 1.0e-76 dnaK; probable chaperone protein DnaK (heat shock protein 70) (heat shock 70 kda protein) (HSP70) K04043; COG: COG0443 Molecular chaperone; Psort location: cytoplasmic, score: 23 YP_001437464.1 COG: NOG21760 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001437465.1 KEGG: mlo:mlr3017 0.0017 5'-nucleotidase K01081; COG: COG1652 Uncharacterized protein containing LysM domain; Psort location: cytoplasmic, score: 23 YP_001437466.1 KEGG: eci:UTI89_C2075 1.1e-143 yecP; hypothetical protein K00599; COG: COG0500 SAM-dependent methyltransferases; Psort location: cytoplasmic, score: 23 YP_001437467.1 KEGG: eci:UTI89_C2074 5.4e-117 yecO; hypothetical protein K00559; COG: COG0500 SAM-dependent methyltransferases; Psort location: cytoplasmic, score: 23 YP_001437468.1 KEGG: hsa:4056 3.4e-05 LTC4S; leukotriene C4 synthase K00807; COG: COG3788 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily; Psort location: cytoplasmic, score: 23 YP_001437469.1 COG: COG1801 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001437470.1 KEGG: eci:UTI89_C2071 2.7e-74 yecD; hypothetical protein; COG: COG1335 Amidases related to nicotinamidase; Psort location: cytoplasmic, score: 23 YP_001437471.1 Psort location: nuclear, score: 23 YP_001437472.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_001437473.1 converts dATP to dAMP and pyrophosphate YP_001437474.1 KEGG: eci:UTI89_C2068 2.6e-124 yebC; hypothetical protein K00975; COG: COG0217 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001437475.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity YP_001437476.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_001437477.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_001437478.1 involved in transport of zinc(II) with ZnuA and C YP_001437479.1 involved in transport of zinc(II) with ZnuA and C YP_001437480.1 involved in transport of zinc(II) with ZnuA and C YP_001437481.1 KEGG: stm:STM1890 5.5e-202 yebA; putative peptidase; COG: COG0739 Membrane proteins related to metalloendopeptidases; Psort location: extracellular, including cell wall, score: 9 YP_001437482.1 Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA YP_001437483.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_001437484.1 Represses the expression of the zwf, eda, glp and gap YP_001437485.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_001437486.1 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate YP_001437487.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate YP_001437488.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis YP_001437489.1 COG: COG3141 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001437490.1 secreted protein; unknown function YP_001437491.1 COG: COG2979 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001437492.1 PtrB; oligopeptidase that cleaves peptide bonds following arginine and lysine residues YP_001437493.1 3'-5' exonuclease activity on single or double-strand DNA YP_001437494.1 KEGG: ece:Z2891 2.2e-31 holE; DNA polymerase III theta subunit K02345; Psort location: cytoplasmic, score: 23 YP_001437495.1 COG: COG2372 Uncharacterized protein, homolog of Cu resistance protein CopC; Psort location: cytoplasmic, score: 23 YP_001437496.1 COG: COG1276 Putative copper export protein; Psort location: endoplasmic reticulum, score: 9 YP_001437497.1 COG: NOG09766 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001437498.1 Psort location: cytoplasmic, score: 23 YP_001437499.1 Psort location: cytoplasmic, score: 23 YP_001437500.1 COG: NOG37778 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001437501.1 Psort location: cytoplasmic, score: 23 YP_001437502.1 Psort location: nuclear, score: 23 YP_001437503.1 Psort location: extracellular, including cell wall, score: 9 YP_001437504.1 Psort location: cytoplasmic, score: 23 YP_001437505.1 KEGG: spt:SPA1020 1.5e-57 pphA; serine/threonine protein phosphatase 1 K07313; COG: COG0639 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases; Psort location: cytoplasmic, score: 23 YP_001437506.1 COG: NOG12164 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437507.1 COG: NOG13883 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001437508.1 in Escherichia coli this enzyme specifically methylates C1407 of the 16S rRNA YP_001437509.1 COG: COG3008 Paraquat-inducible protein B; Psort location: endoplasmic reticulum, score: 9 YP_001437510.1 COG: COG2995 Uncharacterized paraquat-inducible protein A; Psort location: plasma membrane, score: 23 YP_001437511.1 Psort location: cytoplasmic, score: 23 YP_001437512.1 COG: COG1956 GAF domain-containing protein; Psort location: cytoplasmic, score: 23 YP_001437513.1 affects solute and DNA transport through an unknown mechanism YP_001437514.1 Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3 YP_001437515.1 putative metalloprotease YP_001437516.1 Psort location: cytoplasmic, score: 23 YP_001437517.1 COG: COG1414 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001437518.1 COG: NOG13884 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001437519.1 COG: NOG18120 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001437520.1 COG: NOG11327 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001437521.1 KEGG: xla:379989 0.00035 cmah-prov; cytidine monophospho-N-acetylneuraminic acid hydroxylase K08080; COG: COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold; Psort location: cytoplasmic, score: 23 YP_001437522.1 COG: COG1278 Cold shock proteins; Psort location: cytoplasmic, score: 23 YP_001437523.1 KEGG: eci:UTI89_C2020 5.7e-97 yebH; ribosomal RNA large subunit methyltransferase A K00563; COG: COG0500 SAM-dependent methyltransferases; Psort location: extracellular, including cell wall, score: 9 YP_001437524.1 COG: COG1971 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001437525.1 Psort location: cytoplasmic, score: 23 YP_001437526.1 COG: COG4811 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001437527.1 hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel YP_001437528.1 KEGG: eci:UTI89_C2015 1.4e-125 manY; PTS enzyme IIC, mannose-specific K02795; COG: COG3715 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC; Psort location: endoplasmic reticulum, score: 9 YP_001437529.1 KEGG: stm:STM1830 4.9e-155 manX; Sugar Specific PTS family, mannose-specific enzyme IIAB K02793:K02794; COG: COG2893 Phosphotransferase system, mannose/fructose-specific component IIA; Psort location: cytoplasmic, score: 23 YP_001437530.1 Psort location: mitochondrial, score: 23 YP_001437531.1 KEGG: eci:UTI89_C0656 5.4e-22 ybeX; putative transport protein K06189; COG: COG1253 Hemolysins and related proteins containing CBS domains; Psort location: endoplasmic reticulum, score: 23 YP_001437532.1 KEGG: shn:Shewana3_3829 5.7e-32 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) K01745; COG: COG2200 FOG: EAL domain; Psort location: endoplasmic reticulum, score: 23 YP_001437533.1 KEGG: ecc:c2219 7.4e-223 sdaA; L-serine dehydratase 1 K01752; COG: COG1760 L-serine deaminase; Psort location: cytoplasmic, score: 23 YP_001437534.1 KEGG: gbe:GbCGDNIH1_1634 8.5e-32 coA pyrophosphatase K01529; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: cytoplasmic, score: 23 YP_001437535.1 KEGG: stt:t1053 4.0e-176 pabB; para-aminobenzoate synthase component I K01665; COG: COG0147 Anthranilate/para-aminobenzoate synthases component I; Psort location: cytoplasmic, score: 23 YP_001437536.1 COG: COG3140 Uncharacterized protein conserved in bacteria; Psort location: cytoskeletal, score: 9 YP_001437537.1 KEGG: yps:YPTB1971 1.3e-122 putative 3-oxoacyl-(acyl-carrier-protein) synthase III K00648; COG: COG0332 3-oxoacyl-[acyl-carrier-protein] synthase III; Psort location: cytoplasmic, score: 23 YP_001437538.1 KEGG: eci:UTI89_C0871 8.0e-75 ybjS; hypothetical protein YbjS K00067; COG: COG0451 Nucleoside-diphosphate-sugar epimerases; Psort location: cytoplasmic, score: 23 YP_001437539.1 KEGG: fnu:FN1848 3.5e-13 metal dependent hydrolase; COG: COG0491 Zn-dependent hydrolases, including glyoxylases; Psort location: cytoplasmic, score: 23 YP_001437540.1 KEGG: mag:amb1245 1.6e-07 coenzyme F390 synthetase K01912; COG: COG1541 Coenzyme F390 synthetase; Psort location: cytoplasmic, score: 23 YP_001437541.1 KEGG: reh:H16_A2091 2.2e-07 membrane-associated Ser/Thr and Tyr protein phosphatase (dual specificity) K01090; COG: COG0671 Membrane-associated phospholipid phosphatase; Psort location: endoplasmic reticulum, score: 9 YP_001437542.1 KEGG: msm:MSMEG_2812 7.5e-24 C-5 sterol desaturase K00258; COG: COG3000 Sterol desaturase; Psort location: plasma membrane, score: 23 YP_001437543.1 KEGG: cvi:CV2452 1.5e-71 probable linoleoyl-CoA desaturase K00508; COG: COG3239 Fatty acid desaturase; Psort location: endoplasmic reticulum, score: 9 YP_001437544.1 KEGG: cvi:CV2452 1.5e-73 probable linoleoyl-CoA desaturase K00508; COG: COG3239 Fatty acid desaturase; Psort location: endoplasmic reticulum, score: 9 YP_001437545.1 KEGG: mxa:MXAN_0920 0.00049 2-aminomuconate deaminase; COG: COG0251 Putative translation initiation inhibitor, yjgF family; Psort location: cytoplasmic, score: 23 YP_001437546.1 KEGG: sty:STY1951 1.3e-298 putative ATP-dependent helicase K03722; COG: COG1199 Rad3-related DNA helicases; Psort location: cytoplasmic, score: 23 YP_001437547.1 KEGG: ecp:ECP_1750 3.0e-100 hypothetical protease YeaZ K01423; COG: COG1214 Inactive homolog of metal-dependent proteases, putative molecular chaperone; Psort location: cytoplasmic, score: 23 YP_001437548.1 COG: COG3065 Starvation-inducible outer membrane lipoprotein; Psort location: extracellular, including cell wall, score: 9 YP_001437549.1 Activates fatty acids by binding to coenzyme A YP_001437550.1 KEGG: ecc:c2208 9.1e-154 rnd; ribonuclease D K03684; COG: COG0349 Ribonuclease D; Psort location: cytoplasmic, score: 23 YP_001437551.1 works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell YP_001437552.1 ATPase; with MinC inhibits cell division by blocking formation of the polar Z ring septums YP_001437553.1 blocks the formation of polar Z-ring septums YP_001437554.1 COG: COG3100 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001437555.1 KEGG: reu:Reut_A0332 1.2e-39 5-carboxymethyl-2-hydroxymuconate delta-isomerase K01826; COG: COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway); Psort location: cytoplasmic, score: 23 YP_001437556.1 COG: COG2983 Uncharacterized conserved protein; Psort location: mitochondrial, score: 23 YP_001437557.1 Psort location: cytoplasmic, score: 23 YP_001437558.1 disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein YP_001437559.1 involved in regulation of intracellular pH under alkaline conditions YP_001437560.1 Psort location: cytoplasmic, score: 23 YP_001437561.1 Multifunctional regulator of fatty acid metabolism YP_001437562.1 COG: COG2719 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001437563.1 catalyzes the oxidative deamination of D-amino acids YP_001437564.1 catabolic enzyme, converts L-alanine to D-alanine which is then oxidized to pyruvate by dadA YP_001437565.1 the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli YP_001437566.1 COG: COG5470 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001437567.1 Psort location: cytoplasmic, score: 23 YP_001437568.1 catalyzes the release of D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine YP_001437569.1 KEGG: stm:STM1799 1.2e-82 emtA; membrane-bound lytic murein transglycosylase E K08308; COG: COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains); Psort location: cytoplasmic, score: 23 YP_001437570.1 COG: COG5581 Predicted glycosyltransferase; Psort location: cytoplasmic, score: 23 YP_001437571.1 KEGG: cjk:jk1171 0.00057 cdsA; phosphatidate cytidylyltransferase K00981; COG: COG2261 Predicted membrane protein; Psort location: extracellular, including cell wall, score: 23 YP_001437572.1 KEGG: sgl:SG1838 3.9e-27 putative mannonate dehydratase K01686; COG: COG1629 Outer membrane receptor proteins, mostly Fe transport; Psort location: extracellular, including cell wall, score: 9 YP_001437573.1 periplasmic; catalyzes the hydrolysis of trehalose to glucose which can then be imported into the cell YP_001437574.1 KEGG: bur:Bcep18194_B3074 4.0e-96 transcriptional regulator, GntR family with aminotransferase activity K00375; COG: COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs; Psort location: cytoplasmic, score: 23 YP_001437575.1 KEGG: msm:MSMEG_6370 5.7e-26 pcaC; 4-carboxymuconolactone decarboxylase K01607; COG: COG2128 Uncharacterized conserved protein; Psort location: mitochondrial, score: 23 YP_001437576.1 COG: COG3645 Uncharacterized phage-encoded protein; Psort location: cytoplasmic, score: 23 YP_001437577.1 KEGG: eca:ECA0951 5.0e-66 probable NAD(P)H oxidoreductase K00355; COG: COG2249 Putative NADPH-quinone reductase (modulator of drug activity B); Psort location: cytoplasmic, score: 23 YP_001437578.1 COG: COG1309 Transcriptional regulator; Psort location: endoplasmic reticulum, score: 9 YP_001437579.1 COG: NOG11107 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001437580.1 KEGG: pen:PSEEN4477 0.0019 secA; preprotein translocase SecA subunit; COG: COG3318 Predicted metal-binding protein related to the C-terminal domain of SecA; Psort location: cytoplasmic, score: 23 YP_001437581.1 Psort location: cytoplasmic, score: 23 YP_001437582.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_001437583.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_001437584.1 YchH; transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria; ychH presents a class II promoter to bind CRP; unknown function YP_001437585.1 KEGG: syn:sll0794 2.7e-08 corR, merR, cobH, cbiC; cobalt-dependent transcriptional regulator (MerR (mercuric resistance operon regulatory protein)-like domain in N-terminal half), precorrin isomerase, Precorrin-8X methylmutase (in C-terminal half) K01833; COG: COG0789 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001437586.1 putative role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport YP_001437587.1 Psort location: cytoplasmic, score: 23 YP_001437588.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_001437589.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis YP_001437590.1 Incorporates lipoproteins in the outer membrane after they are released by the LolA protein YP_001437591.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins YP_001437592.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_001437593.1 HemK; PrmC; transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB YP_001437594.1 COG: COG3094 Uncharacterized protein conserved in bacteria; Psort location: plasma membrane, score: 23 YP_001437595.1 KEGG: nmu:Nmul_A1387 0.0058 thymidylate kinase K00943; COG: COG2912 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001437596.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis YP_001437597.1 COG: COG0387 Ca2+/H+ antiporter; Psort location: plasma membrane, score: 23 YP_001437598.1 in Escherichia coli this protein putatively regulates the sodium/proton (also pH-independent calcium/proton) antiporter chaA; has weak affinity for calcium and magnesium ions YP_001437599.1 COG: COG3703 Uncharacterized protein involved in cation transport; Psort location: cytoplasmic, score: 23 YP_001437600.1 Psort location: cytoplasmic, score: 23 YP_001437601.1 KEGG: rha:RHA1_ro04742 1.9e-07 phoR; sensor kinase, two-component system K07636; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: plasma membrane, score: 23 YP_001437602.1 COG: COG1553 Uncharacterized conserved protein involved in intracellular sulfur reduction; Psort location: extracellular, including cell wall, score: 9 YP_001437603.1 KEGG: xac:XAC2157 0.00084 cysG; uroporphyrin-III C-methyltransferase K02302; COG: COG3707 Response regulator with putative antiterminator output domain; Psort location: cytoplasmic, score: 23 YP_001437604.1 COG: COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components; Psort location: cytoplasmic, score: 23 YP_001437605.1 KEGG: rha:RHA1_ro08170 7.5e-24 ABC transporter, permease component; COG: COG0600 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001437606.1 KEGG: azo:azo0944 1.1e-86 nasD; putative nitrate transport system, ATP-binding protein; COG: COG1116 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001437607.1 KEGG: eca:ECA2991 0. nasB; nitrite reductase [NAD(P)H] large subunit K00362; COG: COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases; Psort location: mitochondrial, score: 23 YP_001437608.1 KEGG: eca:ECA2990 8.0e-281 nasA; nitrate reductase K00372; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: cytoplasmic, score: 23 YP_001437609.1 COG: COG1881 Phospholipid-binding protein; Psort location: extracellular, including cell wall, score: 9 YP_001437610.1 COG: NOG06760 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001437611.1 two-component response regulator NarL; phosphorylated by NarQ; activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase YP_001437612.1 KEGG: ecp:ECP_1271 1.9e-224 nitrate/nitrite sensor protein NarX K07673; COG: COG3850 Signal transduction histidine kinase, nitrate/nitrite-specific; Psort location: endoplasmic reticulum, score: 9 YP_001437613.1 COG: COG2223 Nitrate/nitrite transporter; Psort location: plasma membrane, score: 23 YP_001437614.1 KEGG: stm:STM1764 0. narG; nitrate reductase alpha chain K00370; COG: COG5013 Nitrate reductase alpha subunit; Psort location: cytoplasmic, score: 23 YP_001437615.1 KEGG: stt:t1672 5.6e-273 narH; respiratory nitrate reductase 1 beta chain K00371; COG: COG1140 Nitrate reductase beta subunit; Psort location: cytoplasmic, score: 23 YP_001437616.1 KEGG: stm:STM1762 1.3e-97 narJ; nitrate reductase delta chain K00373; COG: COG2180 Nitrate reductase delta subunit; Psort location: cytoplasmic, score: 23 YP_001437617.1 KEGG: stm:STM1761 2.8e-104 narI; nitrate reductase gamma chain K00374; COG: COG2181 Nitrate reductase gamma subunit; Psort location: endoplasmic reticulum, score: 9 YP_001437618.1 KEGG: xac:XAC2822 1.1e-05 Ada, AlkA; DNA methylation and regulatory protein K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001437619.1 KEGG: bur:Bcep18194_B0662 7.3e-65 short-chain dehydrogenase/reductase SDR K00044; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001437620.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine YP_001437621.1 KEGG: pen:PSEEN4477 0.00064 secA; preprotein translocase SecA subunit; COG: COG3012 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001437622.1 KEGG: eci:UTI89_C1431 1.4e-148 rssB; RssB/Hnr protein K02485; COG: COG0784 FOG: CheY-like receiver; Psort location: cytoplasmic, score: 23 YP_001437623.1 together with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose YP_001437624.1 KEGG: sgl:SG1368 7.6e-205 putative UDP-glucose dehydrogenase K00012; COG: COG1004 Predicted UDP-glucose 6-dehydrogenase; Psort location: extracellular, including cell wall, score: 23 YP_001437625.1 Psort location: nuclear, score: 23 YP_001437626.1 KEGG: sgl:SG1369 6.2e-139 putative nucleotide sugar epimerase; COG: COG0451 Nucleoside-diphosphate-sugar epimerases; Psort location: cytoplasmic, score: 23 YP_001437627.1 COG: COG2916 DNA-binding protein H-NS; Psort location: nuclear, score: 23 YP_001437628.1 catalyzes the formation of thymidine 5'-phosphate from thymidine YP_001437629.1 KEGG: sbo:SBO_1828 0. adhE; CoA-linked acetaldehyde dehydrogenase/iron-dependent alcohol dehydrogenase K00001:K04072; COG: COG1012 NAD-dependent aldehyde dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001437630.1 COG: COG2095 Multiple antibiotic transporter; Psort location: plasma membrane, score: 23 YP_001437631.1 KEGG: shn:Shewana3_2650 4.1e-20 acetate kinase K00925; COG: COG4166 ABC-type oligopeptide transport system, periplasmic component; Psort location: endoplasmic reticulum, score: 9 YP_001437632.1 KEGG: rha:RHA1_ro09047 1.5e-43 ABC peptide transporter, permease component K02033; COG: COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001437633.1 KEGG: baa:BA_0884 0.0024 binding-protein-dependent transport systems inner membrane component K00294; COG: COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001437634.1 KEGG: rru:Rru_A0589 1.9e-96 oligopeptide/dipeptide ABC transporter, ATP-binding protein-like K02031; COG: COG0444 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001437635.1 KEGG: bur:Bcep18194_B0119 4.2e-94 oligopeptide/dipeptide ABC transporter, ATPase subunit K02032; COG: COG4608 ABC-type oligopeptide transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001437636.1 COG: COG1226 Kef-type K+ transport systems, predicted NAD-binding component; Psort location: endoplasmic reticulum, score: 23 YP_001437637.1 highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein YP_001437638.1 catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol) YP_001437639.1 unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity YP_001437640.1 membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins YP_001437641.1 YciA; hydrolase that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA; member of the the acyl coenzyme A hydrolase family of proteins YP_001437642.1 Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space YP_001437643.1 Involved in cell division; probably involved in intracellular septation YP_001437644.1 COG: NOG06197 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001437645.1 COG: COG0727 Predicted Fe-S-cluster oxidoreductase; Psort location: nuclear, score: 23 YP_001437646.1 receptor for colicin S4 YP_001437647.1 Psort location: nuclear, score: 23 YP_001437648.1 KEGG: sfx:S1349 1.3e-113 trpA; tryptophan synthase, alpha protein K01695; COG: COG0159 Tryptophan synthase alpha chain; Psort location: cytoplasmic, score: 23 YP_001437649.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_001437650.1 monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate YP_001437651.1 bifunctional anthranilate synthase II/anthranilate phosphoribosyltransferase; TrpD; forms a heterotetramer with Trp E and the complex catalyzes the formation of anthranilate from chorismate and glutamine; also catalyzes the formation of N-(5-phospho-D-ribosyl)-anthranilate from athranilate and 5-phospho-alpha-D-ribose 1-diphosphate; functions in tryptophan biosynthesis YP_001437652.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine YP_001437653.1 KEGG: reh:H16_A1200 7.1e-51 predicted metal-dependent phosphoesterase (PHP family); COG: COG0613 Predicted metal-dependent phosphoesterases (PHP family); Psort location: cytoplasmic, score: 23 YP_001437654.1 COG: COG0009 Putative translation factor (SUA5); Psort location: cytoplasmic, score: 23 YP_001437655.1 catalyzes the synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA YP_001437656.1 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide YP_001437657.1 KEGG: eco:b1271 1.9e-105 yciK; short chain dehydrogenase K00100; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001437658.1 SohB; periplasmic protein; member of the peptidase S49 family YP_001437659.1 Psort location: cytoplasmic, score: 23 YP_001437660.1 Psort location: cytoplasmic, score: 23 YP_001437661.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity YP_001437662.1 LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation YP_001437663.1 Psort location: cytoplasmic, score: 23 YP_001437664.1 Catalyzes the conversion of citrate to isocitrate YP_001437665.1 catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate YP_001437666.1 KEGG: spt:SPA1166 2.6e-108 pgpB; phosphatidylglycerophosphatase B K01096; COG: COG0671 Membrane-associated phospholipid phosphatase; Psort location: endoplasmic reticulum, score: 9 YP_001437667.1 COG: COG3771 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001437668.1 KEGG: azo:azo1075 2.6e-60 conserved hypothetical transferase protein; COG: COG2956 Predicted N-acetylglucosaminyl transferase; Psort location: cytoplasmic, score: 23 YP_001437669.1 KEGG: spt:SPA1169 3.2e-103 pyrF; orotidine-5'-P decarboxylase K01591; COG: COG0284 Orotidine-5-phosphate decarboxylase; Psort location: cytoplasmic, score: 23 YP_001437670.1 involved in start site selection during the initiation of translation YP_001437671.1 COG: NOG17005 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001437672.1 COG: COG1349 Transcriptional regulators of sugar metabolism; Psort location: cytoplasmic, score: 23 YP_001437673.1 KEGG: sec:SC0838 0. pflF; putative pyruvate formate lyase K00656; COG: COG1882 Pyruvate-formate lyase; Psort location: cytoplasmic, score: 23 YP_001437674.1 KEGG: ecj:JW0808 9.4e-120 ybiY; predicted pyruvate formate lyase activating enzyme K04069; COG: COG1180 Pyruvate-formate lyase-activating enzyme; Psort location: cytoplasmic, score: 23 YP_001437675.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies YP_001437676.1 COG: NOG34196 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001437677.1 regulator of pathogenicity factor RpfF; involved in synthesis of a diffusible signal factor involved in the regulation of extracellular enzymes YP_001437678.1 c-di-GMP phosphodiesterase; probably degrades signalling molecule c-di-GMP YP_001437679.1 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction YP_001437680.1 COG: COG2128 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001437681.1 Catalyzes a key regulatory step in fatty acid biosynthesis YP_001437682.1 KEGG: bur:Bcep18194_A6388 1.8e-52 oligopeptide/dipeptide ABC transporter, ATPase subunit K02032; COG: COG4167 ABC-type antimicrobial peptide transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001437683.1 KEGG: ret:RHE_CH00739 9.1e-67 dppDch1, dppFch1; dipeptide ABC transporter, ATP-binding protein K02031; COG: COG4170 ABC-type antimicrobial peptide transport system, ATPase component; Psort location: nuclear, score: 23 YP_001437684.1 KEGG: lwe:lwe0999 0.0031 gbuB; glycine betaine/L-proline ABC transporter, permease protein; COG: COG4171 ABC-type antimicrobial peptide transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001437685.1 KEGG: syf:Synpcc7942_2454 5.5e-28 adenine phosphoribosyltransferase K00759; COG: COG4168 ABC-type antimicrobial peptide transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001437686.1 KEGG: shn:Shewana3_2650 1.3e-123 acetate kinase K00925; COG: COG4166 ABC-type oligopeptide transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001437687.1 transcriptional activator for pspABCE which are induced in response to phage proteins, membrane altering stresses, and impaired proton expor YP_001437688.1 involved in maintaining membrane potential under membrane stress conditions; also acts as a negative transcriptional regulator of the phage shock protein (psp) operon(pspABCDE) by regulating the transcriptional activator PspF YP_001437689.1 acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding YP_001437690.1 with PsbB forms toxin/antitoxin pair; activates the psp operon in response to phage infection, exposure to ethanol or osmotic shock YP_001437691.1 COG: NOG14121 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001437692.1 KEGG: ece:Z2475m 4.9e-194 glycosidase K00690; COG: COG0366 Glycosidases; Psort location: endoplasmic reticulum, score: 9 YP_001437693.1 KEGG: eci:UTI89_C1581 5.2e-167 ycjN; putative ABC transporter periplasmic binding protein YcjN precursor K02027; COG: COG1653 ABC-type sugar transport system, periplasmic component; Psort location: mitochondrial, score: 23 YP_001437694.1 KEGG: tel:tlr1429 0.00010 ndhC; NADH dehydrogenase subunit 3 K05574; COG: COG1175 ABC-type sugar transport systems, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001437695.1 KEGG: cyb:CYB_0398 0.0069 modB; molybdate ABC transporter, permease protein K02018; COG: COG0395 ABC-type sugar transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001437696.1 KEGG: hwa:HQ2425A 1.2e-20 tdh; oxidoreductase (probable Zn-dependent dehydrogenases, threonine 3-dehydrogenase) K00060; COG: COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases; Psort location: endoplasmic reticulum, score: 9 YP_001437697.1 KEGG: eci:UTI89_C1585 1.7e-97 ycjR; putative transient receptor potential locus K01820; COG: COG1082 Sugar phosphate isomerases/epimerases; Psort location: cytoplasmic, score: 23 YP_001437698.1 COG: COG0582 Integrase; Psort location: cytoplasmic, score: 23 YP_001437699.1 COG: NOG18529 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437700.1 COG: NOG23864 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437701.1 COG: NOG14124 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437702.1 COG: COG2932 Predicted transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001437703.1 Psort location: mitochondrial, score: 23 YP_001437704.1 COG: NOG14675 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001437705.1 COG: NOG20728 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001437706.1 KEGG: sto:ST0842 6.4e-05 hypothetical ABC transporter ATP-binding protein K02013; COG: COG1106 Predicted ATPases; Psort location: nuclear, score: 23 YP_001437707.1 Psort location: cytoplasmic, score: 23 YP_001437708.1 DLP12 prophage YP_001437709.1 COG: NOG32342 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001437710.1 Psort location: cytoplasmic, score: 23 YP_001437711.1 KEGG: eci:UTI89_C1478 6.3e-27 endodeoxyribonuclease RusA (Holliday junction resolvase) K01160; COG: COG4570 Holliday junction resolvase; Psort location: cytoplasmic, score: 23 YP_001437712.1 COG: NOG18124 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437713.1 Psort location: endoplasmic reticulum, score: 9 YP_001437714.1 COG: NOG20218 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437715.1 KEGG: ecs:ECs0819 3.0e-52 probable endolysin (lysis protein) (lysozyme) K01185; COG: COG3772 Phage-related lysozyme (muraminidase); Psort location: endoplasmic reticulum, score: 9 YP_001437716.1 Psort location: extracellular, including cell wall, score: 9 YP_001437717.1 Psort location: cytoskeletal, score: 9 YP_001437718.1 Psort location: cytoplasmic, score: 23 YP_001437719.1 Psort location: extracellular, including cell wall, score: 9 YP_001437720.1 Psort location: endoplasmic reticulum, score: 9 YP_001437721.1 Psort location: cytoplasmic, score: 23 YP_001437722.1 COG: COG3747 Phage terminase, small subunit; Psort location: cytoplasmic, score: 23 YP_001437723.1 COG: COG4626 Phage terminase-like protein, large subunit; Psort location: cytoplasmic, score: 23 YP_001437724.1 Psort location: extracellular, including cell wall, score: 9 YP_001437725.1 COG: COG4695 Phage-related protein; Psort location: cytoplasmic, score: 23 YP_001437726.1 KEGG: mtu:Rv2651c 0.0082 possible phiRv2 prophage protease; COG: COG3740 Phage head maturation protease; Psort location: cytoplasmic, score: 23 YP_001437727.1 COG: COG4653 Predicted phage phi-C31 gp36 major capsid-like protein; Psort location: cytoplasmic, score: 23 YP_001437728.1 KEGG: pat:Patl_2341 2.1e-05 agarase K01219; COG: COG5492 Bacterial surface proteins containing Ig-like domains; Psort location: cytoplasmic, score: 23 YP_001437729.1 COG: NOG24115 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437730.1 COG: NOG32857 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001437731.1 COG: NOG30834 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001437732.1 COG: NOG22114 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437733.1 COG: COG3778 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001437734.1 COG: COG5301 Phage-related tail fibre protein; Psort location: cytoplasmic, score: 23 YP_001437735.1 Psort location: mitochondrial, score: 23 YP_001437736.1 Psort location: cytoplasmic, score: 23 YP_001437737.1 KEGG: ecc:c1787 9.2e-106 ycjS; hypothetical oxidoreductase YcjS; COG: COG0673 Predicted dehydrogenases and related proteins; Psort location: cytoplasmic, score: 23 YP_001437738.1 KEGG: eci:UTI89_C1587 2.3e-244 ycjT; hypothetical transport protein YcjT; COG: COG1554 Trehalose and maltose hydrolases (possible phosphorylases); Psort location: cytoplasmic, score: 23 YP_001437739.1 KEGG: eco:b1317 6.5e-73 ycjU, pgmB; putative beta phosphoglucomutase, contains a phophatase-like domain K01838; COG: COG0637 Predicted phosphatase/phosphohexomutase; Psort location: endoplasmic reticulum, score: 9 YP_001437740.1 KEGG: sth:STH1782 9.8e-102 sugar ABC transportor ATP-binding protein K05816; COG: COG3839 ABC-type sugar transport systems, ATPase components; Psort location: cytoplasmic, score: 23 YP_001437741.1 KEGG: efa:EF1922 6.3e-09 transcriptional regulator, LacI family/carbohydrate kinase, PfkB family protein K00852; COG: COG1609 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001437742.1 KEGG: sdy:SDY_1399 3.6e-214 ycjX; putative YcjX; COG: COG3106 Predicted ATPase; Psort location: cytoplasmic, score: 23 YP_001437743.1 COG: COG3768 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 23 YP_001437744.1 regulates genes involved in the biosynthesis and transport of aromatic amino acids YP_001437745.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein YP_001437746.1 KEGG: sfl:SF1331 2.1e-131 ycjG; putative muconate cycloisomerase I; COG: COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily; Psort location: cytoplasmic, score: 23 YP_001437747.1 KEGG: gka:GK2441 0.0034 gamma-D-glutamyl-L-diamino acid endopeptidase I (endopeptidase I) K01308; COG: COG2866 Predicted carboxypeptidase; Psort location: cytoplasmic, score: 23 YP_001437748.1 KEGG: shn:Shewana3_2650 2.8e-22 acetate kinase K00925; COG: COG4166 ABC-type oligopeptide transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001437749.1 Psort location: extracellular, including cell wall, score: 9 YP_001437750.1 COG: NOG12165 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001437751.1 Psort location: extracellular, including cell wall, score: 9 YP_001437752.1 Psort location: cytoplasmic, score: 23 YP_001437753.1 Psort location: endoplasmic reticulum, score: 9 YP_001437754.1 Psort location: mitochondrial, score: 23 YP_001437755.1 Psort location: nuclear, score: 23 YP_001437756.1 KEGG: shn:Shewana3_3829 3.6e-41 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) K01745; COG: COG2200 FOG: EAL domain; Psort location: endoplasmic reticulum, score: 9 YP_001437757.1 Psort location: cytoplasmic, score: 23 YP_001437758.1 Psort location: cytoplasmic, score: 23 YP_001437759.1 COG: NOG12162 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437760.1 Psort location: cytoplasmic, score: 23 YP_001437761.1 Psort location: nuclear, score: 23 YP_001437762.1 COG: COG0598 Mg2+ and Co2+ transporters; Psort location: cytoplasmic, score: 23 YP_001437763.1 COG: COG3468 Type V secretory pathway, adhesin AidA; Psort location: nuclear, score: 23 YP_001437764.1 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs YP_001437765.1 Psort location: mitochondrial, score: 23 YP_001437766.1 COG: NOG16515 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437767.1 Psort location: mitochondrial, score: 23 YP_001437768.1 KEGG: bxe:Bxe_B1317 1.1e-102 short-chain dehydrogenase; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001437769.1 KEGG: stl:stu1732 1.5e-34 pmi1; mannose-6-phosphate isomerase K01809; COG: COG1482 Phosphomannose isomerase; Psort location: cytoplasmic, score: 23 YP_001437770.1 KEGG: reh:H16_B1962 6.3e-91 transcriptional regulator, PspF-family K01529; COG: COG3284 Transcriptional activator of acetoin/glycerol metabolism; Psort location: cytoplasmic, score: 23 YP_001437771.1 KEGG: yps:YPTB2197 1.3e-223 probable aldehyde dehydrogenase K00128; COG: COG1012 NAD-dependent aldehyde dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001437772.1 KEGG: aci:ACIAD3339 3.2e-135 adhA; alcohol dehydrogenase K00001; COG: COG1064 Zn-dependent alcohol dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001437773.1 Psort location: endoplasmic reticulum, score: 9 YP_001437774.1 KEGG: ecp:ECP_1403 0. probable pyruvate-flavodoxin oxidoreductase K03737; COG: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit; Psort location: cytoplasmic, score: 23 YP_001437775.1 COG: COG3042 Putative hemolysin; Psort location: nuclear, score: 23 YP_001437776.1 KEGG: net:Neut_1073 0.0038 6-aminohexanoate-dimer hydrolase; COG: COG3187 Heat shock protein; Psort location: extracellular, including cell wall, score: 9 YP_001437777.1 KEGG: ecj:JW1375 6.0e-157 ldhA; fermentative D-lactate dehydrogenase, NAD-dependent K03778; COG: COG1052 Lactate dehydrogenase and related dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001437778.1 COG: NOG06225 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001437779.1 COG: NOG17319 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001437780.1 COG: COG3784 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001437781.1 Psort location: cytoplasmic, score: 23 YP_001437782.1 FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds YP_001437783.1 involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain YP_001437784.1 COG: COG1943 Transposase and inactivated derivatives; Psort location: mitochondrial, score: 23 YP_001437785.1 KEGG: bcz:BCZK1776 8.4e-64 mdmC; O-methyltransferase K00599; COG: COG4122 Predicted O-methyltransferase; Psort location: cytoplasmic, score: 23 YP_001437786.1 COG: COG1538 Outer membrane protein; Psort location: mitochondrial, score: 23 YP_001437787.1 KEGG: bha:BH2653 0.0088 pdhC; pyruvate dehydrogenase E2 (dihydrolipoamide acetyltransferase) K00627; COG: COG1566 Multidrug resistance efflux pump; Psort location: cytoplasmic, score: 23 YP_001437788.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001437789.1 KEGG: son:SO0916 0.0093 putative acetyltransferase K03828; COG: COG1846 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001437790.1 KEGG: sgl:SG1900 1.9e-11 putative acetyltransferase K03829; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: cytoplasmic, score: 23 YP_001437791.1 KEGG: cvi:CV0163 6.8e-46 fofB; fosfomycin resistance protein FofB K00810; COG: COG0346 Lactoylglutathione lyase and related lyases; Psort location: cytoplasmic, score: 23 YP_001437792.1 KEGG: rme:Rmet_0677 0.00029 aldehyde dehydrogenase K00128; COG: COG1434 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001437793.1 NAD-linked YP_001437794.1 KEGG: eca:ECA2408 3.4e-92 paeX; pectin acetylesterase; COG: COG0657 Esterase/lipase; Psort location: peroxisomal, score: 9 YP_001437795.1 KEGG: ecs:ECs2023 2.1e-58 cytochrome b(561); COG: COG3038 Cytochrome B561; Psort location: endoplasmic reticulum, score: 9 YP_001437796.1 KEGG: cal:orf19.4356 5.2e-06 HGT3; high-affinity glucose transporter K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001437797.1 Psort location: extracellular, including cell wall, score: 9 YP_001437798.1 COG: COG1937 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001437799.1 KEGG: stm:STM1627 3.3e-197 alcohol dehydrogenase class III K00001:K00121; COG: COG1062 Zn-dependent alcohol dehydrogenases, class III; Psort location: cytoplasmic, score: 23 YP_001437800.1 KEGG: ret:RHE_PF00265 0.00050 probable two-component sensor histidine kinase/response regulator hybrid protein; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 9 YP_001437801.1 KEGG: rpe:RPE_3645 8.1e-25 catalase K00429; COG: COG3685 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001437802.1 KEGG: bps:BPSS0877 3.1e-114 putative N-ethylmaleimide reductase; COG: COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family; Psort location: cytoplasmic, score: 23 YP_001437803.1 KEGG: shn:Shewana3_3435 0.00012 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001437804.1 Psort location: cytoplasmic, score: 23 YP_001437805.1 COG: COG5383 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001437806.1 KEGG: stm:STM1623 1.5e-206 putative carboxylesterase K03927; COG: COG2272 Carboxylesterase type B; Psort location: cytoplasmic, score: 23 YP_001437807.1 involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans YP_001437808.1 KEGG: sfl:SF1783 1.3e-58 rimL; acetylation of N-terminal serine of 30S ribosomal subunit protein L7; acetyl transferase K03817; COG: COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins; Psort location: cytoplasmic, score: 23 YP_001437809.1 KEGG: syc:syc1734_d 0.0037 acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine o-acyltransferase K00677; COG: NOG06285 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437810.1 Psort location: mitochondrial, score: 23 YP_001437811.1 with TehA confers resistance to tellurite YP_001437812.1 COG: NOG06284 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001437813.1 KEGG: ade:Adeh_3654 0.0043 NADH dehydrogenase (quinone) K05903; COG: COG3135 Uncharacterized protein involved in benzoate metabolism; Psort location: plasma membrane, score: 23 YP_001437814.1 KEGG: psp:PSPPH_2917 0.00023 DNA-binding protein K00517; COG: COG1396 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001437815.1 KEGG: sec:SC1601 0. ydcP; putative collagenase K08303; COG: COG0826 Collagenase and related proteases; Psort location: mitochondrial, score: 23 YP_001437816.1 KEGG: stm:STM1998 1.9e-34 umuD; error-prone repair: SOS-response transcriptional repressors (LexA homologs, RecA-mediated autopeptidases) K03503; COG: COG1974 SOS-response transcriptional repressors (RecA-mediated autopeptidases); Psort location: cytoplasmic, score: 23 YP_001437817.1 KEGG: stm:STM1997 7.7e-141 umuC; error-prone repair: component of DNA polymerase V with UmuD' K03502; COG: COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair; Psort location: cytoplasmic, score: 23 YP_001437818.1 COG: COG4405 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001437819.1 COG: COG2076 Membrane transporters of cations and cationic drugs; Psort location: endoplasmic reticulum, score: 9 YP_001437820.1 with MdtJ is involved in resistance to deoxycholate, nalidixic acid, fosfomycin, and SDS YP_001437821.1 KEGG: sty:STY1583 4.6e-111 putative secreted protein K04775; COG: COG3591 V8-like Glu-specific endopeptidase; Psort location: mitochondrial, score: 23 YP_001437822.1 Psort location: mitochondrial, score: 23 YP_001437823.1 KEGG: yps:YPTB2232 5.0e-185 putative carboxypeptidase K01299; COG: COG2317 Zn-dependent carboxypeptidase; Psort location: mitochondrial, score: 23 YP_001437824.1 KEGG: shn:Shewana3_1692 9.1e-51 Xaa-His dipeptidase K01270; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001437825.1 KEGG: shn:Shewana3_3435 1.3e-26 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001437826.1 KEGG: eci:UTI89_C1781 4.6e-182 mlc; putative NAGC-like transcriptional regulator K00845; COG: COG1940 Transcriptional regulator/sugar kinase; Psort location: cytoplasmic, score: 23 YP_001437827.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium YP_001437828.1 KEGG: bur:Bcep18194_C7553 8.5e-135 ABC glycine betaine/L-proline transporter, ATPase subunit K05847; COG: COG1125 ABC-type proline/glycine betaine transport systems, ATPase components; Psort location: cytoplasmic, score: 23 YP_001437829.1 KEGG: lwe:lwe1439 7.3e-42 glycine betaine/L-proline ABC transporter, permease/glycine betaine/L-proline-binding protein; COG: COG1174 ABC-type proline/glycine betaine transport systems, permease component; Psort location: plasma membrane, score: 23 YP_001437830.1 KEGG: lwe:lwe1439 4.1e-32 glycine betaine/L-proline ABC transporter, permease/glycine betaine/L-proline-binding protein; COG: COG1732 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein); Psort location: extracellular, including cell wall, score: 9 YP_001437831.1 KEGG: lwe:lwe1439 5.4e-37 glycine betaine/L-proline ABC transporter, permease/glycine betaine/L-proline-binding protein; COG: COG1174 ABC-type proline/glycine betaine transport systems, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001437832.1 KEGG: ctr:CT219 0.0074 ubiA; 4-hydroxybenzoate octaprenyltransferase K03179; COG: COG3136 Uncharacterized membrane protein required for alginate biosynthesis; Psort location: endoplasmic reticulum, score: 9 YP_001437833.1 binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane YP_001437834.1 KEGG: eci:UTI89_C1777 4.1e-103 ynfH; anaerobic dimethyl sulfoxide reductase chain YnfH K07312; COG: COG3302 DMSO reductase anchor subunit; Psort location: plasma membrane, score: 23 YP_001437835.1 KEGG: ecp:ECP_0909 2.5e-110 anaerobic dimethyl sulfoxide reductase, subunit B K07307; COG: COG0437 Fe-S-cluster-containing hydrogenase components 1; Psort location: nuclear, score: 23 YP_001437836.1 KEGG: eco:b0894 0. dmsA; anaerobic dimethyl sulfoxide (DMSO) reductase, subunit A K07306; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: cytoplasmic, score: 23 YP_001437837.1 COG: NOG12175 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001437838.1 COG: NOG06202 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001437839.1 KEGG: sec:SC1519 3.6e-88 speG; spermidine N1-acetyltransferase K00657; COG: COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins; Psort location: cytoplasmic, score: 23 YP_001437840.1 COG: NOG11441 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001437841.1 COG: COG1742 Uncharacterized conserved protein; Psort location: extracellular, including cell wall, score: 23 YP_001437842.1 KEGG: eci:UTI89_C1768 1.2e-215 rspA; starvation sensing protein RspA K08323; COG: COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily; Psort location: cytoplasmic, score: 23 YP_001437843.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001437844.1 KEGG: sty:STY1553 1.3e-202 putative D-mannonate oxidoreductase K00040; COG: COG0246 Mannitol-1-phosphate/altronate dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001437845.1 COG: NOG13886 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437846.1 COG: NOG18492 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001437847.1 KEGG: msm:MSMEG_3400 7.8e-08 glutamyl-tRNA(Gln) amidotransferase subunit A K01957; COG: COG1802 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001437848.1 NADP(+)-dependent; catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine YP_001437849.1 KEGG: ece:Z2160 1.6e-259 dcp; dipeptidyl carboxypeptidase II K01284; COG: COG0339 Zn-dependent oligopeptidases; Psort location: cytoplasmic, score: 23 YP_001437850.1 KEGG: rba:RB997 0.00082 ogt; probable O-linked GlcNAc transferase K00754; COG: COG0789 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001437851.1 COG: COG3781 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001437852.1 Psort location: cytoplasmic, score: 23 YP_001437853.1 Psort location: cytoplasmic, score: 23 YP_001437854.1 COG: NOG09007 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001437855.1 catalyzes the formation of tetrahydropteroyl-L-glutamate and methionine from L-homocysteine and 5-methyltetrahydropteroyltri-L-glutamate YP_001437856.1 Psort location: mitochondrial, score: 23 YP_001437857.1 catalyzes the hydrolysis of allophanate YP_001437858.1 KEGG: eca:ECA2142 0. urea amidolyase K01941; COG: COG0439 Biotin carboxylase; Psort location: cytoplasmic, score: 23 YP_001437859.1 KEGG: msm:MSMEG_3400 4.5e-05 glutamyl-tRNA(Gln) amidotransferase subunit A K01957; COG: COG1802 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001437860.1 COG: COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component; Psort location: mitochondrial, score: 23 YP_001437861.1 KEGG: fal:FRAAL3359 1.7e-12 putative sulfate-transporting ATPase K06020; COG: COG0559 Branched-chain amino acid ABC-type transport system, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001437862.1 KEGG: reh:H16_A3653 2.8e-13 ABC-type transporter, ATPase and permease components; COG: COG4177 ABC-type branched-chain amino acid transport system, permease component; Psort location: plasma membrane, score: 23 YP_001437863.1 KEGG: pen:PSEEN4891 4.4e-90 branched-chain amino acid transport ABC transporter, ATP-binding component; COG: COG4674 Uncharacterized ABC-type transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001437864.1 KEGG: pen:PSEEN4892 6.8e-94 branched-chain amino acid ABC transporter, ATP-binding protein; COG: COG0410 ABC-type branched-chain amino acid transport systems, ATPase component; Psort location: cytoplasmic, score: 23 YP_001437865.1 COG: NOG11501 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437866.1 Psort location: nuclear, score: 23 YP_001437867.1 Psort location: endoplasmic reticulum, score: 9 YP_001437868.1 KEGG: nwi:Nwi_0782 3.7e-09 integrase, catalytic region K00986; COG: COG2801 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001437869.1 Psort location: cytoplasmic, score: 23 YP_001437870.1 Psort location: cytoplasmic, score: 23 YP_001437871.1 KEGG: cel:K12C11.4 0.00045 dapk-1; DAP (Death-Associated Protein) Kinase homolog K08803; COG: COG0515 Serine/threonine protein kinase; Psort location: cytoplasmic, score: 23 YP_001437872.1 COG: NOG12280 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437873.1 COG: COG4245 Uncharacterized protein encoded in toxicity protection region of plasmid R478, contains von Willebrand factor (vWF) domain; Psort location: cytoplasmic, score: 23 YP_001437874.1 KEGG: rxy:Rxyl_0636 0.0062 von Willebrand factor, type A; COG: COG4245 Uncharacterized protein encoded in toxicity protection region of plasmid R478, contains von Willebrand factor (vWF) domain; Psort location: cytoplasmic, score: 23 YP_001437875.1 COG: COG2310 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1; Psort location: cytoplasmic, score: 23 YP_001437876.1 COG: COG4245 Uncharacterized protein encoded in toxicity protection region of plasmid R478, contains von Willebrand factor (vWF) domain; Psort location: cytoplasmic, score: 23 YP_001437877.1 Psort location: nuclear, score: 23 YP_001437878.1 Psort location: nuclear, score: 23 YP_001437879.1 COG: NOG27346 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001437880.1 COG: NOG23976 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001437881.1 KEGG: bpm:BURPS1710b_A0703 4.4e-05 citrate lyase, beta subunit, putative K01644; COG: COG2301 Citrate lyase beta subunit; Psort location: extracellular, including cell wall, score: 9 YP_001437882.1 COG: NOG09666 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437883.1 COG: NOG13540 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437884.1 COG: NOG08627 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437885.1 COG: NOG11390 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001437886.1 COG: COG2310 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1; Psort location: cytoplasmic, score: 23 YP_001437887.1 COG: COG2310 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1; Psort location: cytoplasmic, score: 23 YP_001437888.1 COG: COG3793 Tellurite resistance protein; Psort location: cytoplasmic, score: 23 YP_001437889.1 COG: COG0861 Membrane protein TerC, possibly involved in tellurium resistance; Psort location: plasma membrane, score: 23 YP_001437890.1 COG: COG2310 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1; Psort location: cytoplasmic, score: 23 YP_001437891.1 COG: COG2310 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1; Psort location: cytoplasmic, score: 23 YP_001437892.1 COG: COG2310 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1; Psort location: cytoplasmic, score: 23 YP_001437893.1 COG: NOG04673 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001437894.1 Psort location: nuclear, score: 23 YP_001437895.1 YdeF; uncharacterized member of the major facilitator superfamily (MFS) of transporters YP_001437896.1 KEGG: pae:PA1977 1.5e-08 sensor protein GLPS; COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: plasma membrane, score: 23 YP_001437897.1 COG: NOG15370 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001437898.1 transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype; also activates sodA, zwf and micF YP_001437899.1 Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes YP_001437900.1 KEGG: dre:30298 8.5e-07 jak2b; Janus kinase 2b K04447; COG: COG2814 Arabinose efflux permease; Psort location: plasma membrane, score: 23 YP_001437901.1 KEGG: reh:H16_A2781 5.2e-10 predicted epimerase, PhzC/PhzF homolog; COG: COG0384 Predicted epimerase, PhzC/PhzF homolog; Psort location: endoplasmic reticulum, score: 9 YP_001437902.1 KEGG: lwe:lwe1547 5.9e-111 ldhB; L-lactate dehydrogenase K00016; COG: COG0039 Malate/lactate dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001437903.1 KEGG: cvi:CV2951 3.7e-31 probable acetyltransferase K03829; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: cytoplasmic, score: 23 YP_001437904.1 KEGG: shn:Shewana3_3435 1.2e-09 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001437905.1 KEGG: bpm:BURPS1710b_3227 0.0014 fahA; fumarylacetoacetase K01555; Psort location: cytoplasmic, score: 23 YP_001437906.1 in Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase YP_001437907.1 KEGG: pae:PA1438 2.1e-05 probable two-component sensor K07644; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 23 YP_001437908.1 catalyzes the formation of glutamate from glutamine YP_001437909.1 COG: NOG13916 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437910.1 KEGG: bpm:BURPS1710b_A1493 1.4e-25 GGDEF domain protein; COG: COG2199 FOG: GGDEF domain; Psort location: endoplasmic reticulum, score: 9 YP_001437911.1 KEGG: eci:UTI89_C0404 2.3e-45 yaiC; hypothetical protein; COG: COG2199 FOG: GGDEF domain; Psort location: endoplasmic reticulum, score: 23 YP_001437912.1 KEGG: lpn:lpg1490 3.1e-34 cyaA; adenylate cyclase PLUS two component hybrid sensor and regulator K01768; COG: COG2199 FOG: GGDEF domain; Psort location: cytoplasmic, score: 23 YP_001437913.1 KEGG: cvi:CV3493 4.6e-24 probable acetyltransferase protein K00680; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: cytoplasmic, score: 23 YP_001437914.1 catalyzes the formation of D-tagaturonate from D-altronate YP_001437915.1 KEGG: pen:PSEEN0445 4.9e-25 estA; esterase EstA precursor K01044; COG: COG3240 Phospholipase/leciTHInase/hemolysin; Psort location: extracellular, including cell wall, score: 9 YP_001437916.1 cytoplasmic; catalyzes the hydrolysis of trehalose to glucose YP_001437917.1 KEGG: tth:TT_P0222 1.7e-88 probable beta-galactosidase K01190; COG: COG3250 Beta-galactosidase/beta-glucuronidase; Psort location: extracellular, including cell wall, score: 9 YP_001437918.1 KEGG: azo:azo3685 4.7e-118 putative hybrid sensor and regulator protein; COG: COG0642 Signal transduction histidine kinase; Psort location: cytoplasmic, score: 23 YP_001437919.1 Psort location: mitochondrial, score: 23 YP_001437920.1 COG: NOG25409 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001437921.1 COG: NOG25409 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001437922.1 COG: NOG25409 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001437923.1 KEGG: nca:Noca_2832 1.4e-61 cellulose synthase (UDP-forming); COG: COG1215 Glycosyltransferases, probably involved in cell wall biogenesis; Psort location: endoplasmic reticulum, score: 9 YP_001437924.1 Psort location: mitochondrial, score: 23 YP_001437925.1 COG: COG4645 Uncharacterized protein conserved in bacteria; Psort location: plasma membrane, score: 23 YP_001437926.1 Psort location: extracellular, including cell wall, score: 9 YP_001437927.1 KEGG: ava:Ava_3723 6.7e-39 response regulator receiver (CheY) modulated serine phosphatase K01079; COG: COG2208 Serine phosphatase RsbU, regulator of sigma subunit; Psort location: cytoplasmic, score: 23 YP_001437928.1 KEGG: ter:Tery_1523 6.4e-07 anti-sigma-factor antagonist and sugar transfersase K00996; COG: COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor); Psort location: cytoplasmic, score: 23 YP_001437929.1 KEGG: rde:RD1_0027 7.5e-08 rsbW; serine-protein kinase, putative K08282; Psort location: cytoplasmic, score: 23 YP_001437930.1 KEGG: psp:PSPPH_2917 1.3e-08 DNA-binding protein K00517; COG: COG1396 Predicted transcriptional regulators; Psort location: endoplasmic reticulum, score: 9 YP_001437931.1 COG: COG3382 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001437932.1 KEGG: mkm:Mkms_3050 2.3e-13 dephospho-CoA kinase K00859; COG: COG2320 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001437933.1 COG: NOG11501 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437934.1 Psort location: cytoplasmic, score: 23 YP_001437935.1 COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001437936.1 KEGG: bur:Bcep18194_C6615 1.8e-84 alpha/beta hydrolase K00433; COG: COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily); Psort location: cytoplasmic, score: 23 YP_001437937.1 KEGG: eci:UTI89_C3737 8.4e-09 yhdM; Zn(II)-responsive regulator of ZntA; COG: COG0789 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001437938.1 Psort location: nuclear, score: 23 YP_001437939.1 KEGG: eci:UTI89_C1901 1.0e-33 nlpC; probable lipoprotein NlpC precursor; COG: COG0791 Cell wall-associated hydrolases (invasion-associated proteins); Psort location: extracellular, including cell wall, score: 9 YP_001437940.1 Psort location: mitochondrial, score: 23 YP_001437941.1 Psort location: extracellular, including cell wall, score: 9 YP_001437942.1 KEGG: psp:PSPPH_3703 1.1e-123 L-sorbosone dehydrogenase K00100; COG: COG2133 Glucose/sorbosone dehydrogenases; Psort location: extracellular, including cell wall, score: 9 YP_001437943.1 COG: COG4244 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001437944.1 COG: COG3434 Predicted signal transduction protein containing EAL and modified HD-GYP domains; Psort location: cytoplasmic, score: 23 YP_001437945.1 Psort location: endoplasmic reticulum, score: 9 YP_001437946.1 Psort location: endoplasmic reticulum, score: 9 YP_001437947.1 KEGG: cno:NT01CX_0232 5.8e-22 UV DNA damage endonuclease (UV-endonuclease) UvdE; COG: COG4294 UV damage repair endonuclease; Psort location: cytoplasmic, score: 23 YP_001437948.1 KEGG: azo:azo2292 2.5e-05 ada; methylated-DNA--[protein]-cysteine S-methyltransferase K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: mitochondrial, score: 23 YP_001437949.1 KEGG: ret:RHE_CH00288 3.0e-75 putative oxidoreductase protein K00059; COG: COG4221 Short-chain alcohol dehydrogenase of unknown specificity; Psort location: cytoplasmic, score: 23 YP_001437950.1 Psort location: cytoplasmic, score: 23 YP_001437951.1 Psort location: cytoplasmic, score: 23 YP_001437952.1 COG: NOG22744 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001437953.1 KEGG: mbo:Mb3598c 0.00035 possible oxidoreductase; COG: COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family; Psort location: cytoplasmic, score: 23 YP_001437954.1 COG: COG3070 Regulator of competence-specific genes; Psort location: cytoplasmic, score: 23 YP_001437955.1 Psort location: cytoplasmic, score: 23 YP_001437956.1 KEGG: rpa:RPA0109 9.2e-58 putative 3-oxoacyl-(acyl carrier ptn) reductase K00059; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001437957.1 KEGG: rfr:Rfer_2439 1.8e-134 alcohol dehydrogenase, zinc-binding K00002; COG: COG1064 Zn-dependent alcohol dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001437958.1 KEGG: sru:SRU_2774 4.1e-16 pcaC; 4-carboxymuconolactone decarboxylase domain protein K01607; COG: COG2128 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001437959.1 KEGG: bli:BL05281 4.0e-07 adaA; methylphosphotriester-DNA alkyltransferase and transcriptional regulator (AraC/XylS family) K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001437960.1 KEGG: ssn:SSO_1662 3.0e-59 putative N-hydroxyarylamine O-acetyltransferase K00675; COG: COG2162 Arylamine N-acetyltransferase; Psort location: cytoplasmic, score: 23 YP_001437961.1 COG: COG3685 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001437962.1 KEGG: reu:Reut_B4409 4.9e-107 catalase K07217; COG: COG3546 Mn-containing catalase; Psort location: cytoplasmic, score: 23 YP_001437963.1 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown YP_001437964.1 KEGG: eci:UTI89_C0578 5.6e-51 nfnB; oxygen-insensitive NAD(P)H nitroreductase K00357; COG: COG0778 Nitroreductase; Psort location: golgi, score: 9 YP_001437965.1 KEGG: bur:Bcep18194_C7532 5.9e-95 beta-lactamase K01467; COG: COG1680 Beta-lactamase class C and other penicillin binding proteins; Psort location: extracellular, including cell wall, score: 9 YP_001437966.1 COG: NOG38279 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001437967.1 KEGG: eci:UTI89_C0120 9.8e-86 aroP; aromatic amino acid transport protein AroP K03293; COG: COG1113 Gamma-aminobutyrate permease and related permeases; Psort location: plasma membrane, score: 23 YP_001437968.1 COG: NOG10065 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001437969.1 COG: COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components; Psort location: extracellular, including cell wall, score: 9 YP_001437970.1 Psort location: cytoplasmic, score: 23 YP_001437971.1 KEGG: pst:PSPTO_5198 3.2e-119 dioxygenase, TauD/TfdA family K03119; COG: COG2175 Probable taurine catabolism dioxygenase; Psort location: cytoplasmic, score: 23 YP_001437972.1 KEGG: reh:H16_B2218 1.3e-92 ABC-type transporter, ATPase component: NitT family; COG: COG1116 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001437973.1 KEGG: lwe:lwe1444 2.1e-13 opuCB; glycine betaine/L-proline ABC transporter, permease protein; COG: COG0600 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001437974.1 COG: COG3391 Uncharacterized conserved protein; Psort location: extracellular, including cell wall, score: 9 YP_001437975.1 COG: COG1629 Outer membrane receptor proteins, mostly Fe transport; Psort location: extracellular, including cell wall, score: 9 YP_001437976.1 COG: COG3093 Plasmid maintenance system antidote protein; Psort location: mitochondrial, score: 23 YP_001437977.1 COG: COG3549 Plasmid maintenance system killer protein; Psort location: mitochondrial, score: 23 YP_001437978.1 KEGG: ret:RHE_CH02260 2.5e-103 putative trehalose synthase (glycosyl hydrolase) protein K05343; COG: COG0366 Glycosidases; Psort location: cytoplasmic, score: 23 YP_001437979.1 KEGG: noc:Noc_0472 3.7e-77 short chain dehydrogenase K00059; COG: COG4221 Short-chain alcohol dehydrogenase of unknown specificity; Psort location: cytoplasmic, score: 23 YP_001437980.1 KEGG: vch:VCA0709 2.1e-08 torS; sensor protein TorS K07647; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 9 YP_001437981.1 Psort location: mitochondrial, score: 23 YP_001437982.1 KEGG: msm:MSMEG_3400 2.5e-11 glutamyl-tRNA(Gln) amidotransferase subunit A K01957; COG: COG1802 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001437983.1 KEGG: shn:Shewana3_2650 2.9e-29 acetate kinase K00925; COG: COG0747 ABC-type dipeptide transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001437984.1 KEGG: baa:BA_0884 1.5e-06 binding-protein-dependent transport systems inner membrane component K00294; COG: COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001437985.1 KEGG: rha:RHA1_ro09047 4.5e-49 ABC peptide transporter, permease component K02033; COG: COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001437986.1 KEGG: gox:GOX2239 1.4e-16 hypothetical protein K01436; COG: COG0624 AcetylorniTHIne deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases; Psort location: cytoplasmic, score: 23 YP_001437987.1 KEGG: sdn:Sden_0589 3.1e-34 orniTHIne cyclodeaminase K01750; COG: COG2423 Predicted orniTHIne cyclodeaminase, mu-crystallin homolog; Psort location: extracellular, including cell wall, score: 9 YP_001437988.1 KEGG: rru:Rru_A2011 6.2e-100 ABC transporter component K06020:K06021; COG: COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase; Psort location: cytoplasmic, score: 23 YP_001437989.1 Psort location: cytoplasmic, score: 23 YP_001437990.1 KEGG: ece:Z2270 6.4e-153 yncB; putative oxidoreductase; COG: COG2130 Putative NADP-dependent oxidoreductases; Psort location: cytoplasmic, score: 23 YP_001437991.1 KEGG: psp:PSPPH_2917 5.7e-10 DNA-binding protein K00517; COG: COG1396 Predicted transcriptional regulators; Psort location: nuclear, score: 23 YP_001437992.1 KEGG: ecj:JW5233 8.8e-69 yncA; predicted acyltransferase with acyl-CoA N-acyltransferase domain K03823; COG: COG1247 Sortase and related acyltransferases; Psort location: cytoplasmic, score: 23 YP_001437993.1 COG: COG3238 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001437994.1 KEGG: xcc:XCC0308 6.6e-80 dehydrogenase K00100; COG: COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001437995.1 COG: NOG13890 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001437996.1 KEGG: shn:Shewana3_2650 5.2e-119 acetate kinase K00925; COG: COG0747 ABC-type dipeptide transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001437997.1 KEGG: cal:orf19.4334 1.2e-10 hypothetical protein K00960; COG: NOG35976 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001437998.1 COG: COG4457 Uncharacterized protein conserved in bacteria, putative virulence factor; Psort location: cytoplasmic, score: 23 YP_001437999.1 COG: COG4458 Uncharacterized protein conserved in bacteria, putative virulence factor; Psort location: cytoplasmic, score: 23 YP_001438000.1 Psort location: mitochondrial, score: 23 YP_001438001.1 Psort location: endoplasmic reticulum, score: 9 YP_001438002.1 KEGG: cal:orf19.2606 0.0029 HDA1; histone deacetylase A; COG: NOG12157 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001438003.1 KEGG: hma:rrnAC0265 9.6e-05 apl; AP-endonuclease/AP-lyase K01151:K01741; COG: COG1082 Sugar phosphate isomerases/epimerases; Psort location: cytoplasmic, score: 23 YP_001438004.1 KEGG: cvi:CV1579 7.6e-07 probable two-component hybrid sensor and regulator; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 9 YP_001438005.1 KEGG: ava:Ava_3999 2.9e-33 phytase K01083; COG: COG4222 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001438006.1 KEGG: mba:Mbar_A2589 1.7e-10 heterodisulfate reductase, subunit A K03388; COG: COG1145 Ferredoxin; Psort location: mitochondrial, score: 23 YP_001438007.1 KEGG: dsy:DSY0355 2.7e-28 dmsC; putative anaerobic DMSO reductase chain C anchor subunit K00369; COG: COG3302 DMSO reductase anchor subunit; Psort location: plasma membrane, score: 23 YP_001438008.1 KEGG: dsy:DSY0356 2.9e-61 dmsB; putative anaerobic DMSO reductase chain B iron-sulfur subunit K00369; COG: COG0437 Fe-S-cluster-containing hydrogenase components 1; Psort location: nuclear, score: 23 YP_001438009.1 KEGG: dsy:DSY0357 1.0e-239 dmsA; putative anaerobic DMSO reductase chain A precursor K00369; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: cytoplasmic, score: 23 YP_001438010.1 KEGG: reh:H16_A1591 1.0e-90 membrane-bound alcohol dehydrogenase,cytochromec subunit precursor K00119; COG: COG2010 Cytochrome c, mono- and diheme variants; Psort location: extracellular, including cell wall, score: 9 YP_001438011.1 KEGG: mmu:17161 0.00085 Maoa; monoamine oxidase A K00274; COG: NOG06242 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001438012.1 Psort location: nuclear, score: 23 YP_001438013.1 Psort location: extracellular, including cell wall, score: 9 YP_001438014.1 KEGG: btk:BT9727_1901 0.0021 acetyltransferase, GNAT family K00680; Psort location: mitochondrial, score: 23 YP_001438015.1 KEGG: bur:Bcep18194_A5735 0.00031 GCN5-related N-acetyltransferase K00657; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: cytoplasmic, score: 23 YP_001438016.1 KEGG: reh:H16_B1292 1.7e-10 phnT; acetyltransferase (GNAT) family K00680; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: mitochondrial, score: 23 YP_001438017.1 Psort location: nuclear, score: 23 YP_001438018.1 catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation YP_001438019.1 KEGG: pac:PPA0505 3.4e-10 ABC transporter, putative molybdenum transport system K02017:K02018; COG: COG1177 ABC-type spermidine/putrescine transport system, permease component II; Psort location: endoplasmic reticulum, score: 9 YP_001438020.1 KEGG: cdi:DIP0495 2.3e-09 putative molybdenum ABC transport system (integral membrane and ATP-binding proteins) K02017:K02018; COG: COG1176 ABC-type spermidine/putrescine transport system, permease component I; Psort location: endoplasmic reticulum, score: 9 YP_001438021.1 Psort location: cytoplasmic, score: 23 YP_001438022.1 KEGG: ssn:SSO_1696 1.6e-131 putative ATP-binding component of a transport system K02052; COG: COG3842 ABC-type spermidine/putrescine transport systems, ATPase components; Psort location: cytoplasmic, score: 23 YP_001438023.1 COG: COG0687 Spermidine/putrescine-binding periplasmic protein; Psort location: extracellular, including cell wall, score: 9 YP_001438024.1 KEGG: eci:UTI89_C1658 5.1e-192 ydcR; hypothetical protein YdcR K00811; COG: COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs; Psort location: cytoplasmic, score: 23 YP_001438025.1 KEGG: stm:STM0360 8.5e-222 cytochrome BD2 subunit I K00425; COG: COG1271 Cytochrome bd-type quinol oxidase, subunit 1; Psort location: plasma membrane, score: 23 YP_001438026.1 KEGG: sec:SC0402 1.6e-147 cydB; cytochrome BD2 subunit II K00426; COG: COG1294 Cytochrome bd-type quinol oxidase, subunit 2; Psort location: plasma membrane, score: 23 YP_001438027.1 COG: NOG22122 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001438028.1 Psort location: cytoplasmic, score: 23 YP_001438029.1 COG: COG1309 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001438030.1 KEGG: syn:slr0813 0.0012 ceramide glucosyltransferase K00720; COG: COG2076 Membrane transporters of cations and cationic drugs; Psort location: endoplasmic reticulum, score: 9 YP_001438031.1 KEGG: eci:UTI89_C4210 8.4e-80 yicJ; hypothetical symporter YicJ K03292; COG: COG2211 Na+/melibiose symporter and related transporters; Psort location: plasma membrane, score: 23 YP_001438032.1 KEGG: sma:SAV5743 6.1e-132 abfA; putative alpha-L-arabinofuranosidase K01209; COG: COG3534 Alpha-L-arabinofuranosidase; Psort location: cytoplasmic, score: 23 YP_001438033.1 COG: NOG06288 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001438034.1 KEGG: shn:Shewana3_2650 8.5e-11 acetate kinase K00925; COG: COG0747 ABC-type dipeptide transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001438035.1 KEGG: rha:RHA1_ro09047 7.6e-47 ABC peptide transporter, permease component K02033; COG: COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001438036.1 KEGG: lwe:lwe1444 0.00066 opuCB; glycine betaine/L-proline ABC transporter, permease protein; COG: COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001438037.1 KEGG: fal:FRAAL3863 3.6e-120 putative ABC transport protein, ATPase component; COG: COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase; Psort location: endoplasmic reticulum, score: 9 YP_001438038.1 KEGG: fal:FRAAL4791 9.5e-56 putative monooxigenase; COG: COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases; Psort location: cytoplasmic, score: 23 YP_001438039.1 KEGG: azo:azo2506 1.6e-05 cmd; 4-carboxymuconolactone decarboxylase K01607; COG: COG2128 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001438040.1 KEGG: ecj:JW0806 4.2e-94 ybiV; predicted hydrolase K07757; COG: COG0561 Predicted hydrolases of the HAD superfamily; Psort location: cytoplasmic, score: 23 YP_001438041.1 COG: COG2840 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001438042.1 Psort location: nuclear, score: 23 YP_001438043.1 KEGG: ece:Z2432 5.5e-76 ogt; O-6-alkylguanine-DNA/cysteine-protein methyltransferase K00567; COG: COG0350 Methylated DNA-protein cysteine methyltransferase; Psort location: cytoplasmic, score: 23 YP_001438044.1 Global transcription factor that controls the expression of over 100 target genes in response to anoxia YP_001438045.1 with UspC and UspD is involved in resistance to UV irradiation YP_001438046.1 catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme YP_001438047.1 forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm YP_001438048.1 COG: NOG06063 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001438049.1 KEGG: eci:UTI89_C0120 2.1e-08 aroP; aromatic amino acid transport protein AroP K03293; COG: COG0531 Amino acid transporters; Psort location: plasma membrane, score: 23 YP_001438050.1 response regulator in two-component regulatory system with RstB YP_001438051.1 KEGG: bur:Bcep18194_C7235 4.9e-52 short-chain dehydrogenase/reductase SDR K00059; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001438052.1 KEGG: shn:Shewana3_3435 6.5e-08 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001438053.1 KEGG: sty:STY1651 2.7e-177 rstB; two component sensor kinase K07639; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 9 YP_001438054.1 binds to DNA replication terminator sequences to prevent passage of replication forks YP_001438055.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle YP_001438056.1 KEGG: spt:SPA1387 4.8e-274 fumA; Fumarate hydratase class I, aerobic K01676; COG: COG1951 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain; Psort location: cytoplasmic, score: 23 YP_001438057.1 KEGG: stm:STM1467 3.4e-170 manA; mannose-6-phosphate isomerase K01809; COG: COG1482 Phosphomannose isomerase; Psort location: cytoplasmic, score: 23 YP_001438058.1 COG: COG5339 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001438059.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001438060.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001438061.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001438062.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001438063.1 COG: COG3188 P pilus assembly protein, porin PapC; Psort location: cytoplasmic, score: 23 YP_001438064.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: extracellular, including cell wall, score: 9 YP_001438065.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001438066.1 regulates malXY which are involved in maltose-glucose transport YP_001438067.1 phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS); catalyzes the phosphorylation of maltose and glucose concomitant with their translocation across the cell membrane; component IIB catalyzes the phosphorylation of the sugar molecule; IIC forms the translocation channel and contains the substrate specific binding site YP_001438068.1 KEGG: ece:Z2627 2.3e-155 malY; enzyme that may degrade or block biosynthesis of endogenous mal inducer, probably aminotrasferase K01760; COG: COG1168 Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities; Psort location: cytoplasmic, score: 23 YP_001438069.1 KEGG: stt:t1331 2.1e-147 add; adenosine deaminase K01488; COG: COG1816 Adenosine deaminase; Psort location: cytoplasmic, score: 23 YP_001438070.1 COG: COG0385 Predicted Na+-dependent transporter; Psort location: plasma membrane, score: 23 YP_001438071.1 Psort location: nuclear, score: 23 YP_001438072.1 KEGG: eci:UTI89_C1812 6.9e-156 ydgJ; hypothetical oxidoreductase YdgJ; COG: COG0673 Predicted dehydrogenases and related proteins; Psort location: cytoplasmic, score: 23 YP_001438073.1 YdgT; in E. coli, when complexed with H-NS or StpA binds a 26 base-pair DNA sequence of oriC; seems to play a role in optimizing the activity of oriC; non-essential; Hha protein paralog; in an hha mutant background, cnu is overexpressed and can compensate hha-induced phenotypes YP_001438074.1 COG: NOG08686 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001438075.1 KEGG: vfi:VF0935 1.9e-75 Na(+)-translocating NADH-quinone reductase subunit E K03617; COG: COG4657 Predicted NADH:ubiquinone oxidoreductase, subunit RnfA; Psort location: plasma membrane, score: 23 YP_001438076.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen YP_001438077.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen YP_001438078.1 RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents YP_001438079.1 part of membrane-bound complex hought to be involved in electron transport to nitrogen YP_001438080.1 in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase YP_001438081.1 KEGG: stm:STM1453 9.8e-102 nth; endonuclease III; DNA glycosylase/apyrimidinic (AP) lyase K07457; COG: COG0177 Predicted EndoIII-related endonuclease; Psort location: cytoplasmic, score: 23 YP_001438082.1 mutations in this gene confer resistance to the toxic peptide alafosfalin in Salmonella typhimurium; member of proton-dependent oligopeptide transport (POT) system family; in Escherichia coli this gene is regulated by OmpR although not via osmoregulation YP_001438083.1 KEGG: spt:SPA1402 6.5e-73 gst; glutathione S-transferase K00799; COG: COG0625 glutathione S-transferase; Psort location: cytoplasmic, score: 23 YP_001438084.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal YP_001438085.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) YP_001438086.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate YP_001438087.1 MliC; membrane-bound lysozyme inhibitor of c-type lysozyme YP_001438088.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling YP_001438089.1 COG: COG3133 Outer membrane lipoprotein; Psort location: extracellular, including cell wall, score: 9 YP_001438090.1 Transcription regulator that can both activate or repress expression YP_001438091.1 COG: NOG13888 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001438092.1 COG: COG1566 Multidrug resistance efflux pump; Psort location: mitochondrial, score: 23 YP_001438093.1 COG: COG1289 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001438094.1 SodC; copper and zinc binding; converts superoxide radicals to hydrogen peroxide and water YP_001438095.1 KEGG: ecc:c2039 5.0e-130 ydhF; hypothetical oxidoreductase YdhF; COG: COG4989 Predicted oxidoreductase; Psort location: cytoplasmic, score: 23 YP_001438096.1 COG: COG3313 Predicted Fe-S protein; Psort location: nuclear, score: 23 YP_001438097.1 with ZipA and an unidentified 24 kDa protein forms a complex involved in cell division YP_001438098.1 KEGG: bpm:BURPS1710b_A2293 3.8e-36 TetR-family regulatory protein K00356; COG: COG1309 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001438099.1 FMN-linked; catalyzes the formation of N-ethylsuccinimide from N-ethylmaleimide YP_001438100.1 Ni-dependent; catalyzes the formation of S-lactoylglutathione from methylglyoxal and glutathione YP_001438101.1 Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A) YP_001438102.1 KEGG: ama:AM1083 1.2e-07 grxC1; glutaredoxin 3 K03676; COG: COG0278 Glutaredoxin-related protein; Psort location: cytoplasmic, score: 23 YP_001438103.1 Psort location: cytoplasmic, score: 23 YP_001438104.1 Psort location: endoplasmic reticulum, score: 9 YP_001438105.1 KEGG: ssn:SSO_1501 1.4e-61 ydhO; putative lipoprotein K01183; COG: COG0791 Cell wall-associated hydrolases (invasion-associated proteins); Psort location: cytoplasmic, score: 23 YP_001438106.1 KEGG: tbd:Tbd_2790 0.0027 dsbD; THIol:disulfide interchange protein DsbD K04084; COG: COG2814 Arabinose efflux permease; Psort location: plasma membrane, score: 23 YP_001438107.1 Psort location: cytoplasmic, score: 23 YP_001438108.1 binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers YP_001438109.1 KEGG: shn:Shewana3_3435 0.0012 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001438110.1 uncharacterized member of the major facilitator superfamily (MFS) YP_001438111.1 catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge YP_001438112.1 KEGG: eca:ECA2488 2.7e-186 PTS system, cellobiose-specific IIc component K02761; COG: COG1455 Phosphotransferase system cellobiose-specific component IIC; Psort location: plasma membrane, score: 23 YP_001438113.1 KEGG: eca:ECA4407 2.5e-213 putative glycosyl hydrolase K05350; COG: COG2723 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase; Psort location: cytoplasmic, score: 23 YP_001438114.1 KEGG: efa:EF1922 0.0089 transcriptional regulator, LacI family/carbohydrate kinase, PfkB family protein K00852; COG: COG1609 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001438115.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine YP_001438116.1 NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones YP_001438117.1 Psort location: nuclear, score: 23 YP_001438118.1 Psort location: cytoplasmic, score: 23 YP_001438119.1 COG: NOG22997 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001438120.1 Psort location: cytoplasmic, score: 23 YP_001438121.1 Psort location: cytoplasmic, score: 23 YP_001438122.1 COG: COG3501 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001438123.1 Psort location: cytoplasmic, score: 23 YP_001438124.1 COG: COG3501 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001438125.1 COG: COG3521 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 23 YP_001438126.1 COG: COG3520 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001438127.1 COG: COG3519 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001438128.1 COG: COG3523 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001438129.1 KEGG: bpm:BURPS1710b_A0534 5.7e-48 hypothetical protein K00356; COG: COG3517 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001438130.1 COG: COG3516 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001438131.1 Psort location: mitochondrial, score: 23 YP_001438132.1 COG: COG3911 Predicted ATPase; Psort location: extracellular, including cell wall, score: 9 YP_001438133.1 proton-motive-force-driven choline transporter YP_001438134.1 HTH-type; bet1; Repressor involved in choline regulation of the bet genes YP_001438135.1 catalyzes the formation of betaine from betaine aldehyde YP_001438136.1 catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine YP_001438137.1 COG: COG3791 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001438138.1 Psort location: cytoplasmic, score: 23 YP_001438139.1 Psort location: cytoplasmic, score: 23 YP_001438140.1 KEGG: sgl:SG1466 2.1e-08 dethiobiotinsynthase K01935; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001438141.1 COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001438142.1 COG: COG3376 High-affinity nickel permease; Psort location: endoplasmic reticulum, score: 9 YP_001438143.1 KEGG: pfu:PF0283 2.0e-05 putative acylphosphatase K01512; COG: COG0068 Hydrogenase maturation factor; Psort location: cytoplasmic, score: 23 YP_001438144.1 KEGG: eca:ECA1250 0. fdhF; formate dehydrogenase H K00123; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: cytoplasmic, score: 23 YP_001438145.1 involved in electron transport from formate to hydrogen YP_001438146.1 Involved in glycogen synthesis. May be involved in glycogen priming YP_001438147.1 involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE YP_001438148.1 KEGG: eci:UTI89_C3081 2.3e-45 hycH; formate hydrogenlyase maturation protein HycH; COG: NOG09848 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001438149.1 KEGG: eci:UTI89_C3082 1.8e-116 hycG; formate hydrogenlyase subunit 7; COG: COG3260 Ni,Fe-hydrogenase III small subunit; Psort location: cytoplasmic, score: 23 YP_001438150.1 electron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate YP_001438151.1 KEGG: eci:UTI89_C3084 4.1e-300 hycE; formate hydrogenlyase subunit 5 precursor; COG: COG3261 Ni,Fe-hydrogenase III large subunit; Psort location: cytoplasmic, score: 23 YP_001438152.1 KEGG: eci:UTI89_C3085 8.1e-130 hycD; membrane-spanning protein of formate hydrogenase; COG: COG0650 Formate hydrogenlyase subunit 4; Psort location: plasma membrane, score: 23 YP_001438153.1 catalyzes the oxidation of formate to carbon dioxide and molecular hydrogen; formate hydrogenlyase comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (subunit 3) YP_001438154.1 KEGG: eci:UTI89_C3087 6.0e-70 hycB; formate hydrogenlyase subunit 2; COG: COG1142 Fe-S-cluster-containing hydrogenase components 2; Psort location: nuclear, score: 23 YP_001438155.1 regulates several genes involved in the formate hydrogenlyase system; seems to prevent binding of FhlA transcriptional activator to the activator sequence of hyc operon YP_001438156.1 COG: COG0375 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression); Psort location: cytoplasmic, score: 23 YP_001438157.1 GTP hydrolase involved in nickel liganding into hydrogenases YP_001438158.1 HypC; accessory protein necessary for maturation of the hydrogenase isoforms 1, 2 and 3; forms a complex with HypD, HypE, and HypF proteins, which is the site of ligand biosynthesis and attachment to the iron atom of the NiFe site in the hydrogenase YP_001438159.1 COG: COG0409 Hydrogenase maturation factor; Psort location: cytoplasmic, score: 23 YP_001438160.1 KEGG: cch:Cag_0556 3.2e-80 hypE; hydrogenase expression/formation protein HypE K04655; COG: COG0309 Hydrogenase maturation factor; Psort location: cytoplasmic, score: 23 YP_001438161.1 KEGG: eci:UTI89_C3094 2.9e-283 fhlA; formate hydrogenlyase transcriptional activator K01768; COG: COG3604 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains; Psort location: cytoplasmic, score: 23 YP_001438162.1 KEGG: eci:UTI89_C0120 7.0e-12 aroP; aromatic amino acid transport protein AroP K03293; COG: COG0531 Amino acid transporters; Psort location: plasma membrane, score: 23 YP_001438163.1 Psort location: nuclear, score: 23 YP_001438164.1 KEGG: ecs:ECs1874 7.3e-216 putative glutamine synthetase K01915; COG: COG0174 Glutamine synthetase; Psort location: cytoplasmic, score: 23 YP_001438165.1 catalyzes the degradation of gamma-glutamyl-gamma-aminobutyrate into glutamate and gamma-aminobutyrate YP_001438166.1 regulates genes involved in putrescine degradation YP_001438167.1 Psort location: cytoplasmic, score: 23 YP_001438168.1 catalyzes the formation of gamma-glutamyl-gamma-aminobutyrate from Gamma-glutamyl-gamma-aminobutyraldehyde; involved in putrescine degradation YP_001438169.1 KEGG: ecj:JW1294 1.2e-190 puuB; gamma-Glu-putrescine oxidase, FAD/NAD(P)-binding; COG: COG0665 Glycine/D-amino acid oxidases (deaminating); Psort location: cytoplasmic, score: 23 YP_001438170.1 KEGG: eci:UTI89_C1139 6.9e-134 putative autotransporter; COG: COG3468 Type V secretory pathway, adhesin AidA; Psort location: cytoplasmic, score: 23 YP_001438171.1 KEGG: gbe:GbCGDNIH1_1646 5.1e-105 glycosyltransferase K00754; COG: NOG08921 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001438172.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_001438173.1 COG: COG4238 Murein lipoprotein; Psort location: nuclear, score: 23 YP_001438174.1 KEGG: eci:UTI89_C2228 1.1e-72 erfK; hypothetical protein K00257; COG: COG1376 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001438175.1 Acts with SufS to catalyze the formation of L-alanine from L-cysteine YP_001438176.1 catalyzes the formation of L-alanine and selenide or sulfanylcysteine from selenocysteine or cysteine YP_001438177.1 with SufBC activates cysteine desulfurase SufS YP_001438178.1 part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE YP_001438179.1 with SufCD activates cysteine desulfurase SufS YP_001438180.1 functions as a scaffold on which iron-sulfur clusters ([2Fe-2S]; [4Fe-4S]) are assembled; forms a homodimer; similar to IscA protein YP_001438181.1 KEGG: ecp:ECP_0985 1.4e-132 periplasmic AppA protein precursor K01078:K01093; COG: NOG06767 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001438182.1 KEGG: eco:b1686 6.0e-54 ydiI; hypothetical protein; COG: COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism; Psort location: cytoskeletal, score: 9 YP_001438183.1 KEGG: eci:UTI89_C1879 0. ydiJ; hypothetical protein YdiJ; COG: COG0247 Fe-S oxidoreductase; Psort location: cytoplasmic, score: 23 YP_001438184.1 YdiK; inner membrane protein; ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated; unknown function YP_001438185.1 KEGG: ppr:PBPRA0461 9.2e-248 putative xylosidase K05349; COG: COG1472 Beta-glucosidase-related glycosidases; Psort location: cytoplasmic, score: 23 YP_001438186.1 uncharacterized member of the GPH family of galactose-pentose-hexuronide transporters YP_001438187.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_001438188.1 COG: COG1806 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001438189.1 tryptophan sensitive; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate YP_001438190.1 COG: COG0397 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001438191.1 COG: COG2200 FOG: EAL domain; Psort location: cytoplasmic, score: 23 YP_001438192.1 KEGG: msm:MSMEG_3095 4.2e-05 D-ribose-binding periplasmic protein; COG: COG1609 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001438193.1 KEGG: plu:plu2757 5.7e-177 celF; 6-phospho-beta-glucosidase (cellobiose-6-phosphate hydrolase) K01222; COG: COG1486 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases; Psort location: cytoplasmic, score: 23 YP_001438194.1 KEGG: eca:ECA2488 2.4e-114 PTS system, cellobiose-specific IIc component K02761; COG: COG1455 Phosphotransferase system cellobiose-specific component IIC; Psort location: plasma membrane, score: 23 YP_001438195.1 KEGG: eci:UTI89_C1901 1.3e-67 nlpC; probable lipoprotein NlpC precursor; COG: COG0791 Cell wall-associated hydrolases (invasion-associated proteins); Psort location: extracellular, including cell wall, score: 9 YP_001438196.1 ATP-binding protein that acts with the transmembrane protein BtuC and the solute binding protein BtuF to transport vitamin B12 into the cell YP_001438197.1 similar to glutathione peroxidase; member of the btuCED operon which is required for vitamin B12 transport across the inner membrane YP_001438198.1 with BtuD and BtuF transports vitamin B12 into the cell YP_001438199.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_001438200.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_001438201.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_001438202.1 Psort location: cytoplasmic, score: 23 YP_001438203.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_001438204.1 COG: COG0291 Ribosomal protein L35; Psort location: cytoplasmic, score: 23 YP_001438205.1 Psort location: cytoplasmic, score: 23 YP_001438206.1 Psort location: cytoplasmic, score: 23 YP_001438207.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits YP_001438208.1 KEGG: stt:t1213 1.7e-246 thrS; threonyl-tRNA synthetase K01868; COG: COG0441 Threonyl-tRNA synthetase; Psort location: cytoplasmic, score: 23 YP_001438209.1 Psort location: endoplasmic reticulum, score: 9 YP_001438210.1 KEGG: bur:Bcep18194_A5735 3.2e-48 GCN5-related N-acetyltransferase K00657; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: cytoplasmic, score: 23 YP_001438211.1 COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001438212.1 KEGG: ecp:ECP_4098 1.8e-109 acetyl-hydrolase K01066; COG: COG0657 Esterase/lipase; Psort location: cytoplasmic, score: 23 YP_001438213.1 KEGG: tte:TTE0537 6.8e-07 rimI3; Acetyltransferases K03789; COG: NOG16293 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001438214.1 COG: COG4574 Serine protease inhibitor ecotin; Psort location: extracellular, including cell wall, score: 9 YP_001438215.1 Psort location: extracellular, including cell wall, score: 9 YP_001438216.1 KEGG: cal:orf19.2425 5.1e-05 highly conserved hypothetical protein K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001438217.1 Psort location: extracellular, including cell wall, score: 9 YP_001438218.1 COG: COG3137 Putative salt-induced outer membrane protein; Psort location: cytoplasmic, score: 23 YP_001438219.1 KEGG: stm:STM1326 4.7e-134 pfkB; 6-phosphofructokinase II K00850; COG: COG1105 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB); Psort location: extracellular, including cell wall, score: 9 YP_001438220.1 COG: NOG12163 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001438221.1 KEGG: eci:UTI89_C1919 2.2e-127 yniA; hypothetical protein YniA K00924; COG: COG3001 Fructosamine-3-kinase; Psort location: cytoplasmic, score: 23 YP_001438222.1 COG: NOG07880 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 23 YP_001438223.1 YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate YP_001438224.1 KEGG: vvy:VVA1401 1.9e-96 dehydrogenase K00065; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001438225.1 COG: COG1988 Predicted membrane-bound metal-dependent hydrolases; Psort location: endoplasmic reticulum, score: 9 YP_001438226.1 KEGG: eci:UTI89_C4668 3.0e-36 gltP; glutamate-aspartate symport protein K03309; COG: COG1823 Predicted Na+/dicarboxylate symporter; Psort location: plasma membrane, score: 23 YP_001438227.1 COG: COG3093 Plasmid maintenance system antidote protein; Psort location: cytoplasmic, score: 23 YP_001438228.1 COG: COG3549 Plasmid maintenance system killer protein; Psort location: mitochondrial, score: 23 YP_001438229.1 COG: COG3549 Plasmid maintenance system killer protein; Psort location: cytoplasmic, score: 23 YP_001438230.1 COG: NOG11329 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001438231.1 Catalase HPII; monofunctional catalase that decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide YP_001438232.1 osmotically-inducible lipoprotein E; activator of ntr-like gene protein YP_001438233.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers YP_001438234.1 KEGG: pae:PA1977 0.0011 sensor protein GLPS; COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: plasma membrane, score: 23 YP_001438235.1 3' incision activity; acts with UvrC YP_001438236.1 COG: COG3758 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001438237.1 periplasmic protein induced by stress response via Cpx and BaeSR system; similar to CpxP YP_001438238.1 catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism YP_001438239.1 catalyzes the hydrolysis of 2-N-succinylarginine into 2-N-succinylornithine, ammonia and carbon dioxide in arginine degradation YP_001438240.1 KEGG: eco:b1746 1.4e-210 astD, ydjU; succinylglutamic semialdehyde dehydrogenase K06447; COG: COG1012 NAD-dependent aldehyde dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001438241.1 KEGG: ecj:JW1736 4.4e-154 astA; arginine succinyltransferase K00673; COG: COG3138 Arginine/orniTHIne N-succinyltransferase beta subunit; Psort location: cytoplasmic, score: 23 YP_001438242.1 catalyzes the transamination of 2-N-succinylornithine and alpha-ketoglutarate into 2-N-succinylglutamate semialdehyde and glutamate; also functions as the catabolic acetylornithine aminotransferase catalyzing the formation of 2-N-acetylglutamate semialdehyde and glutamate from 2-N-acetylornithine and alpha-ketoglutarate YP_001438243.1 removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction YP_001438244.1 KEGG: eco:b1759 5.5e-44 nudG, ynjG, orf135; CTP pyrophosphohydrolase K08320; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: cytoplasmic, score: 23 YP_001438245.1 COG: NOG11328 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001438246.1 decatenates replicating daughter chromosomes YP_001438247.1 catalyzes the formation of selenophosphate from selenide and ATP YP_001438248.1 Psort location: mitochondrial, score: 23 YP_001438249.1 KEGG: sbo:SBO_1322 1.1e-77 ydjA; hypothetical protein; COG: COG0778 Nitroreductase; Psort location: endoplasmic reticulum, score: 9 YP_001438250.1 SppA; catalyzes the degradation of cleaved signal peptides; essential to maintain secretion of mature proteins across the membrane YP_001438251.1 converts asparagine to aspartate and ammonia YP_001438252.1 catalyzes the formation of nicotinate from nicotinamide in NAD biosynthesis and the formation of pyrazinoate from pyrazinamide YP_001438253.1 COG: COG3139 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001438254.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress YP_001438255.1 KEGG: ecs:ECs2488 5.4e-172 glyceraldehyde-3-phosphate dehydrogenase A K00134; COG: COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Psort location: cytoplasmic, score: 23 YP_001438256.1 KEGG: azo:azo1660 1.3e-35 conserved hypothetical protein K01785; COG: COG0676 Uncharacterized enzymes related to aldose 1-epimerase; Psort location: cytoplasmic, score: 23 YP_001438257.1 COG: COG3713 Outer membrane protein V; Psort location: cytoplasmic, score: 23 YP_001438258.1 KEGG: eci:UTI89_C1979 0. yeaG; hypothetical protein K07180; COG: COG2766 Putative Ser protein kinase; Psort location: cytoplasmic, score: 23 YP_001438259.1 KEGG: eci:UTI89_C1980 7.0e-211 yeaH; hypothetical protein YeaH K00754; COG: COG2718 Uncharacterized conserved protein; Psort location: nuclear, score: 23 YP_001438260.1 KEGG: vfi:VF0494 2.9e-26 sensory transduction protein kinase; COG: COG4943 Predicted signal transduction protein containing sensor and EAL domains; Psort location: endoplasmic reticulum, score: 9 YP_001438263.1 COG: COG3729 General stress protein; Psort location: cytoplasmic, score: 23 YP_001438264.1 COG: COG2606 Uncharacterized conserved protein; Psort location: endoplasmic reticulum, score: 9 YP_001438265.1 COG: COG2707 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001438266.1 KEGG: gme:Gmet_0086 1.9e-05 2-acyl-glycerophospho-ethanolamine acyltransferase K05939:K01909; COG: COG2807 Cyanate permease; Psort location: plasma membrane, score: 23 YP_001438267.1 KEGG: aba:Acid345_2856 7.2e-58 CTP synthase K01937; COG: COG0504 CTP synthase (UTP-ammonia lyase); Psort location: extracellular, including cell wall, score: 9 YP_001438268.1 KEGG: eci:UTI89_C1988 1.3e-35 yeaO; hypothetical protein K00589; COG: COG3189 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001438269.1 Psort location: cytoplasmic, score: 23 YP_001438270.1 COG: NOG29442 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001438271.1 Psort location: mitochondrial, score: 23 YP_001438272.1 COG: COG2990 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001438273.1 Psort location: cytoplasmic, score: 23 YP_001438274.1 Psort location: cytoplasmic, score: 23 YP_001438275.1 KEGG: stm:STM2314 2.4e-121 putative chemotaxis signal transduction protein K03415; COG: COG0784 FOG: CheY-like receiver; Psort location: cytoplasmic, score: 23 YP_001438276.1 Psort location: cytoplasmic, score: 23 YP_001438277.1 Psort location: nuclear, score: 23 YP_001438278.1 Psort location: cytoplasmic, score: 23 YP_001438279.1 COG: COG1278 Cold shock proteins; Psort location: nuclear, score: 23 YP_001438280.1 COG: COG1278 Cold shock proteins; Psort location: cytoplasmic, score: 23 YP_001438281.1 COG: COG1636 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001438282.1 Psort location: extracellular, including cell wall, score: 9 YP_001438283.1 KEGG: bxe:Bxe_B3011 1.7e-06 CheA signal transduction histidine kinases (STHK); COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 9 YP_001438284.1 Psort location: cytoplasmic, score: 23 YP_001438285.1 Psort location: mitochondrial, score: 23 YP_001438286.1 Psort location: cytoplasmic, score: 23 YP_001438287.1 KEGG: bxe:Bxe_A4064 3.4e-44 putative lipase/esterase; COG: COG0657 Esterase/lipase; Psort location: cytoplasmic, score: 23 YP_001438288.1 KEGG: shn:Shewana3_3435 0.0048 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001438290.1 KEGG: azo:azo3708 9.2e-19 dioxygenase-family protein K01759; COG: COG0346 Lactoylglutathione lyase and related lyases; Psort location: cytoplasmic, score: 23 YP_001438291.1 Psort location: cytoplasmic, score: 23 YP_001438292.1 Psort location: extracellular, including cell wall, score: 9 YP_001438293.1 Psort location: cytoplasmic, score: 23 YP_001438294.1 Converts isocitrate to alpha ketoglutarate YP_001438295.1 KEGG: eci:UTI89_C1264 1.7e-95 rluE; 23S rRNA pseudouridine synthase K06181; COG: COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; Psort location: nuclear, score: 23 YP_001438296.1 KEGG: ece:Z1863 4.4e-67 putative phosphohydrolase; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: cytoplasmic, score: 23 YP_001438297.1 KEGG: mma:MM2965 9.7e-27 hypothetical sensory transduction histidine kinase; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 23 YP_001438298.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_001438299.1 HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis YP_001438300.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_001438301.1 response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress YP_001438302.1 KEGG: sty:STY1270 1.9e-199 phoQ; sensor protein PhoQ, regulator of virulence determinants K07637; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 9 YP_001438303.1 COG: COG2850 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001438304.1 catalyzes the release of the N-terminal amino acid from a tripeptide YP_001438305.1 Psort location: cytoplasmic, score: 23 YP_001438306.1 functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase YP_001438307.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component YP_001438308.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component YP_001438309.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotD is a periplasmic component that binds the substrate YP_001438310.1 KEGG: stm:STM1221 1.6e-115 cobB; putative nicotinate-nucleotide dimethylbenzimidazolephosphoribosltransferase, homolog of virulence factor K01463; COG: COG0846 NAD-dependent protein deacetylases, SIR2 family; Psort location: cytoplasmic, score: 23 YP_001438311.1 catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine YP_001438312.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane YP_001438313.1 KEGG: pen:PSEEN3707 1.0e-67 lipoprotein releasing system, ATP-binding protein LolD; COG: COG1136 ABC-type antimicrobial peptide transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001438314.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane YP_001438315.1 KEGG: eci:UTI89_C1242 0. mfd; transcription-repair coupling factor; mutation frequency decline K03723; COG: COG1197 Transcription-repair coupling factor (superfamily II helicase); Psort location: cytoplasmic, score: 23 YP_001438316.1 KEGG: eci:UTI89_C2228 2.1e-74 erfK; hypothetical protein K00257; COG: COG1376 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001438317.1 COG: NOG13874 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001438318.1 COG: COG1309 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001438319.1 COG: COG3134 Predicted outer membrane lipoprotein; Psort location: endoplasmic reticulum, score: 9 YP_001438320.1 KEGG: stt:t1709 1.2e-215 ndh; NADH dehydrogenase K03885; COG: COG1252 NADH dehydrogenase, FAD-containing subunit; Psort location: cytoplasmic, score: 23 YP_001438321.1 COG: COG3150 Predicted esterase; Psort location: mitochondrial, score: 23 YP_001438322.1 hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides YP_001438323.1 catalyzes the phosphorylation of thiamine to thiamine phosphate YP_001438324.1 KEGG: sco:SCO1554 0.0025 SCL11.10c; putative nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase K04719; COG: COG3417 Collagen-binding surface adhesin SpaP (antigen I/II family); Psort location: extracellular, including cell wall, score: 9 YP_001438325.1 COG: COG5633 Predicted periplasmic lipoprotein; Psort location: extracellular, including cell wall, score: 9 YP_001438326.1 KEGG: eci:UTI89_C1231 1.4e-54 ycfF; HIT-like protein YcfF K01518; COG: COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases; Psort location: cytoplasmic, score: 23 YP_001438327.1 COG: COG4773 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid; Psort location: extracellular, including cell wall, score: 9 YP_001438328.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_001438329.1 KEGG: eco:b1100 6.4e-121 ycfH; hypothetical protein K03424; COG: COG0084 Mg-dependent DNase; Psort location: cytoplasmic, score: 23 YP_001438330.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA YP_001438331.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) YP_001438332.1 KEGG: eco:b1097 2.9e-150 yceG; predicted aminodeoxychorismate lyase; COG: COG1559 Predicted periplasmic solute-binding protein; Psort location: extracellular, including cell wall, score: 23 YP_001438333.1 KEGG: sec:SC1148 8.8e-85 pabC; 4-amino-4-deoxychorismate lyase K02619; COG: COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; Psort location: cytoplasmic, score: 23 YP_001438334.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_001438336.1 carries the fatty acid chain in fatty acid biosynthesis YP_001438337.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_001438338.1 KEGG: stm:STM1194 8.1e-146 fabD; malonyl-CoA-[acyl-carrier-protein] transacylase K00645; COG: COG0331 (acyl-carrier-protein) S-malonyltransferase; Psort location: endoplasmic reticulum, score: 9 YP_001438339.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs YP_001438340.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY YP_001438341.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_001438342.1 COG: COG1399 Predicted metal-binding, possibly nucleic acid-binding protein; Psort location: cytoplasmic, score: 23 YP_001438343.1 COG: COG0424 Nucleotide-binding protein implicated in inhibition of septum formation; Psort location: extracellular, including cell wall, score: 9 YP_001438344.1 KEGG: sag:SAG0445 0.0082 valS; valyl-tRNA synthetase K01873; COG: NOG06217 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001438345.1 catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA YP_001438346.1 bifunctional ribonuclease E/endoribonuclease/RNA-binding protein/RNA degradosome binding protein; forms part of the membrane-associated degradosome complex along with PNPase, RhlB, and enolase YP_001438347.1 KEGG: shn:Shewana3_3435 3.7e-10 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001438348.1 KEGG: shn:Shewana3_1692 2.2e-08 Xaa-His dipeptidase K01270; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001438349.1 with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of this and other flagellar genes YP_001438350.1 with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook YP_001438351.1 Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space YP_001438352.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum YP_001438353.1 part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod YP_001438354.1 makes up the distal portion of the flagellar basal body rod YP_001438355.1 FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod YP_001438356.1 the hook connects flagellar basal body to the flagellar filament YP_001438357.1 acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production YP_001438358.1 with FlgF and B makes up the proximal portion of the flagellar basal body rod YP_001438359.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella YP_001438360.1 required for the assembly of the flagellar basal body P-ring YP_001438361.1 regulates the flagellar specific sigma28 transcription factor YP_001438362.1 COG: COG3418 Flagellar biosynthesis/type III secretory pathway chaperone; Psort location: nuclear, score: 23 YP_001438363.1 COG: COG0728 Uncharacterized membrane protein, putative virulence factor; Psort location: plasma membrane, score: 23 YP_001438364.1 KEGG: lpl:lp_0813 1.0e-33 oxidoreductase (putative) K03810; COG: COG0673 Predicted dehydrogenases and related proteins; Psort location: extracellular, including cell wall, score: 9 YP_001438365.1 COG: COG3132 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001438366.1 KEGG: ece:Z1703 9.0e-99 rimJ; acetylation of N-terminal alanine of 30S ribosomal subunit protein S5 K03790; COG: COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins; Psort location: cytoplasmic, score: 23 YP_001438367.1 Psort location: nuclear, score: 23 YP_001438368.1 Confers resistance to norfloxacin and enoxacin YP_001438369.1 cofactor involved in the reduction of disulfides YP_001438370.1 COG: NOG07875 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001438371.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis YP_001438372.1 Psort location: cytoplasmic, score: 23 YP_001438373.1 BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing YP_001438374.1 catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids YP_001438375.1 KEGG: reh:H16_A3123 2.2e-24 cytochrome b561 K00156; COG: COG3038 Cytochrome B561; Psort location: endoplasmic reticulum, score: 9 YP_001438376.1 COG: COG2353 Uncharacterized conserved protein; Psort location: extracellular, including cell wall, score: 9 YP_001438377.1 KEGG: pub:SAR11_1074 1.4e-22 yceA; rhodanese domain protein; COG: COG1054 Predicted sulfurtransferase; Psort location: cytoplasmic, score: 23 YP_001438378.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA YP_001438379.1 COG: NOG09842 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001438380.1 COG: COG5645 Predicted periplasmic lipoprotein; Psort location: extracellular, including cell wall, score: 23 YP_001438381.1 necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space YP_001438382.1 involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan YP_001438383.1 required for the transfer of succinyl residues to the glucan backbone YP_001438384.1 KEGG: reh:H16_B1107 4.6e-111 phospholipase D K01115; COG: COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipi n synthases and related enzymes; Psort location: cytoplasmic, score: 23 YP_001438385.1 KEGG: reh:H16_A1552 3.0e-45 predicted phosphatase homolog to the C-terminal domain of histone macroH2A1; COG: COG2110 Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1; Psort location: cytoplasmic, score: 23 YP_001438386.1 KEGG: abo:ABO_0612 0.0079 pilD; Leaderpeptidase and N-methyltransferase K02654; COG: NOG09737 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001438387.1 KEGG: vfi:VFA0083 3.5e-07 ynfI; anaerobic dimethyl sulfoxide reductase chain YnfI K00397; COG: COG3381 Uncharacterized component of anaerobic dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001438388.1 KEGG: eci:UTI89_C1155 3.0e-45 ycdX; hypothetical protein K04477; COG: COG1387 Histidinol phosphatase and related hydrolases of the PHP family; Psort location: cytoplasmic, score: 23 YP_001438389.1 Psort location: cytoplasmic, score: 23 YP_001438390.1 Psort location: cytoplasmic, score: 23 YP_001438391.1 Psort location: plasma membrane, score: 23 YP_001438392.1 Psort location: nuclear, score: 23 YP_001438393.1 Psort location: cytoplasmic, score: 23 YP_001438394.1 KEGG: bam:Bamb_4258 1.9e-09 lysozyme K01185; COG: NOG21649 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001438395.1 KEGG: fnu:FN0522 0.0070 exonuclease SBCC K03546; Psort location: endoplasmic reticulum, score: 9 YP_001438396.1 COG: COG4733 Phage-related protein, tail component; Psort location: cytoplasmic, score: 23 YP_001438397.1 Psort location: cytoplasmic, score: 23 YP_001438398.1 KEGG: nma:NMA0905 6.3e-06 iga; IgA1 protease K01347; COG: COG5281 Phage-related minor tail protein; Psort location: nuclear, score: 23 YP_001438399.1 Psort location: nuclear, score: 23 YP_001438400.1 Psort location: cytoplasmic, score: 23 YP_001438401.1 COG: NOG31760 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001438402.1 KEGG: chu:CHU_0597 0.00010 CHU large protein; uncharacterized K01238; COG: COG3210 Large exoproteins involved in heme utilization or adhesion; Psort location: cytoplasmic, score: 23 YP_001438403.1 Psort location: cytoplasmic, score: 23 YP_001438404.1 KEGG: ddi:DDB0191487 3.3e-06 kinX; LISK family protein kinase K05743; COG: COG1340 Uncharacterized archaeal coiled-coil protein; Psort location: cytoplasmic, score: 23 YP_001438405.1 COG: COG5511 Bacteriophage capsid protein; Psort location: cytoplasmic, score: 23 YP_001438406.1 COG: COG5525 Bacteriophage tail assembly protein; Psort location: nuclear, score: 23 YP_001438407.1 Psort location: cytoplasmic, score: 23 YP_001438408.1 KEGG: cal:orf19.2410 0.0056 IMH1; involved in vesicular transport K01553; Psort location: nuclear, score: 23 YP_001438409.1 COG: NOG30563 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001438410.1 COG: NOG13962 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001438411.1 Psort location: cytoplasmic, score: 23 YP_001438412.1 KEGG: vfi:VF0494 8.8e-05 sensory transduction protein kinase; COG: COG2200 FOG: EAL domain; Psort location: cytoplasmic, score: 23 YP_001438413.1 Psort location: cytoplasmic, score: 23 YP_001438414.1 Psort location: endoplasmic reticulum, score: 9 YP_001438415.1 Psort location: extracellular, including cell wall, score: 9 YP_001438416.1 Psort location: nuclear, score: 23 YP_001438417.1 Psort location: cytoplasmic, score: 23 YP_001438418.1 Psort location: nuclear, score: 23 YP_001438419.1 Psort location: endoplasmic reticulum, score: 9 YP_001438420.1 Psort location: cytoplasmic, score: 23 YP_001438421.1 Psort location: cytoplasmic, score: 23 YP_001438422.1 KEGG: msu:MS0629 0.0094 surA; parvulin-like peptidyl-prolyl isomerase K03771; Psort location: nuclear, score: 23 YP_001438423.1 Psort location: endoplasmic reticulum, score: 9 YP_001438424.1 COG: COG1961 Site-specific recombinases, DNA invertase Pin homologs; Psort location: cytoplasmic, score: 23 YP_001438425.1 KEGG: eci:UTI89_C1155 7.6e-63 ycdX; hypothetical protein K04477; COG: COG1387 Histidinol phosphatase and related hydrolases of the PHP family; Psort location: cytoplasmic, score: 23 YP_001438426.1 KEGG: eco:b1033 2.1e-115 ycdW; 2-ketoacid reductase K00049; COG: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001438427.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001438428.1 COG: COG3188 P pilus assembly protein, porin PapC; Psort location: cytoplasmic, score: 23 YP_001438429.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: extracellular, including cell wall, score: 9 YP_001438430.1 Psort location: cytoplasmic, score: 23 YP_001438431.1 KEGG: bur:Bcep18194_C6997 7.9e-258 oxidoreductase alpha (molybdopterin) subunit K00122; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: cytoplasmic, score: 23 YP_001438432.1 KEGG: reh:H16_A0527 8.1e-43 phoH; phosphate starvation-inducible protein PhoH,predicted ATPase; COG: COG1702 Phosphate starvation-inducible protein PhoH, predicted ATPase; Psort location: cytoplasmic, score: 23 YP_001438433.1 KEGG: reh:H16_B0946 7.0e-05 predicted iron-dependent peroxidase K00430; COG: COG2837 Predicted iron-dependent peroxidase; Psort location: cytoplasmic, score: 23 YP_001438434.1 COG: COG2822 Predicted periplasmic lipoprotein involved in iron transport; Psort location: extracellular, including cell wall, score: 9 YP_001438435.1 COG: COG0672 High-affinity Fe2+/Pb2+ permease; Psort location: plasma membrane, score: 23 YP_001438436.1 COG: COG1972 Nucleoside permease; Psort location: plasma membrane, score: 23 YP_001438437.1 COG: NOG18370 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001438438.1 KEGG: rde:RD1_2839 1.7e-06 sensor histidine kinase, putative; COG: COG0591 Na+/proline symporter; Psort location: plasma membrane, score: 23 YP_001438439.1 Psort location: mitochondrial, score: 23 YP_001438440.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichai coli this protein also self-regulates transcription via a DNA-binding domain at the N-terminus; forms dimers and is a peripherally membrane-associated protein YP_001438441.1 COG: NOG26382 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001438442.1 COG: NOG26268 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001438443.1 KEGG: bcl:ABC2937 5.2e-05 NADH dehydrogenase K03885; COG: COG1309 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001438444.1 Psort location: endoplasmic reticulum, score: 9 YP_001438445.1 KEGG: ecs:ECs1258 4.0e-167 hypothetical protein K09018; COG: COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases; Psort location: cytoplasmic, score: 23 YP_001438446.1 KEGG: ssn:SSO_1030 3.1e-105 putative synthetase K09020; COG: COG1335 Amidases related to nicotinamidase; Psort location: cytoplasmic, score: 23 YP_001438447.1 KEGG: ape:APE_1501.1 2.2e-10 ribonuclease UK114; COG: COG0251 Putative translation initiation inhibitor, yjgF family; Psort location: extracellular, including cell wall, score: 9 YP_001438448.1 KEGG: pae:PA0480 4.5e-17 putative beta-ketoadipate enol-lactone hydrolase K01055; COG: COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily); Psort location: cytoplasmic, score: 23 YP_001438449.1 KEGG: ecs:ECs1254 6.3e-75 putative enzyme K09019; COG: COG0778 Nitroreductase; Psort location: cytoplasmic, score: 23 YP_001438450.1 KEGG: ecc:c1144 2.6e-62 ycdH; putative flavin:NADH reductase YcdH K09024; COG: COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family; Psort location: cytoplasmic, score: 23 YP_001438451.1 KEGG: bcz:BCZK0244 2.3e-10 guanine-hypoxanTHIne permease; xanTHIne/uracil permease family protein K06901; COG: COG2233 XanTHIne/uracil permeases; Psort location: plasma membrane, score: 23 YP_001438452.1 Psort location: cytoplasmic, score: 23 YP_001438453.1 KEGG: mav:MAV_3849 6.3e-27 wrbA; NAD(P)H:quinone oxidoreductase, type IV K00355; COG: COG0655 Multimeric flavodoxin WrbA; Psort location: cytoplasmic, score: 23 YP_001438454.1 COG: NOG13872 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001438455.1 KEGG: sus:Acid_6874 8.1e-43 beta-lactamase K01467; COG: COG0491 Zn-dependent hydrolases, including glyoxylases; Psort location: cytoplasmic, score: 23 YP_001438456.1 COG: NOG25608 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001438457.1 COG: COG3515 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001438458.1 COG: COG3518 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001438459.1 COG: COG3515 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001438460.1 KEGG: shn:Shewana3_2650 1.2e-30 acetate kinase K00925; COG: COG4166 ABC-type oligopeptide transport system, periplasmic component; Psort location: endoplasmic reticulum, score: 9 YP_001438461.1 COG: COG0670 Integral membrane protein, interacts with FtsH; Psort location: endoplasmic reticulum, score: 9 YP_001438462.1 transfers sulfur from TusBCD complex to MnmA; involved in thiouridation of U34 position of some tRNAs YP_001438463.1 KEGG: stm:STM1083 4.0e-34 yccX; putative phosphohydrolase K01512; COG: COG1254 Acylphosphatases; Psort location: cytoplasmic, score: 23 YP_001438464.1 KEGG: eci:UTI89_C1034 2.1e-193 yccW; hypothetical protein YccW K06969; COG: COG1092 Predicted SAM-dependent methyltransferases; Psort location: cytoplasmic, score: 23 YP_001438465.1 COG: COG3785 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001438466.1 KEGG: rru:Rru_A2075 1.3e-30 O-acetylhomoserine/O-acetylserine sulfhydrylase K01740; COG: COG1832 Predicted CoA-binding protein; Psort location: cytoplasmic, score: 23 YP_001438467.1 catalyzes the formation of methylglyoxal from glycerone phosphate YP_001438468.1 catalyzes the ATP-dependent unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand YP_001438469.1 COG: COG3304 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001438470.1 KEGG: eco:b3358 3.9e-29 yhfK; conserved inner membrane protein K01823; COG: COG1289 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001438471.1 COG: COG3070 Regulator of competence-specific genes; Psort location: cytoplasmic, score: 23 YP_001438472.1 COG: COG5404 SOS-response cell division inhibitor, blocks FtsZ ring formation; Psort location: nuclear, score: 23 YP_001438473.1 OmpA is believed to be a porin, involved in diffusion of nonspecific small solutes across the outer membrane. It is the most abundant integral protein of the outer membrane of E. coli, and it is known to play a role as a phage receptor, a mediator of F-factor dependent conjugation, and in maintaining the structural shape of the outer membrane; 3a; II*; G; d YP_001438474.1 COG: COG3120 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001438475.1 KEGG: ecp:ECP_0960 5.8e-207 putative protease La K04770; COG: COG1067 Predicted ATP-dependent protease; Psort location: cytoplasmic, score: 23 YP_001438476.1 catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP YP_001438477.1 COG: COG3009 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001438478.1 COG: COG3008 Paraquat-inducible protein B; Psort location: mitochondrial, score: 23 YP_001438479.1 COG: COG2995 Uncharacterized paraquat-inducible protein A; Psort location: plasma membrane, score: 23 YP_001438480.1 Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth YP_001438481.1 catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA YP_001438482.1 KEGG: eci:UTI89_C0875 1.2e-05 hcr; NADH oxidoreductase; COG: COG0633 Ferredoxin; Psort location: cytoplasmic, score: 23 YP_001438483.1 COG: NOG07913 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001438484.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors YP_001438485.1 KEGG: eco:b0937 2.2e-72 ssuE, suE, ycbP, ssi4; NAD(P)H-dependent FMN reductase K00299; COG: COG0431 Predicted flavoprotein; Psort location: mitochondrial, score: 23 YP_001438486.1 KEGG: mav:MAV_3808 0.0013 2'-hydroxybiphenyl-2-sulfinate desulfinase K05977; COG: COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components; Psort location: extracellular, including cell wall, score: 9 YP_001438487.1 catalyzes the release of sulfite from alkanesulfonates YP_001438488.1 part of the ABC type transport system for alkanesulfonate SsuABC; SsuB the ATP-binding subunit and SsuC the permease YP_001438489.1 part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic substrate-binding subunit, SsuB the ATP-binding subunit and SsuC the permease YP_001438490.1 KEGG: stm:STM1057 0. pepN; aminopeptidase N K01256; COG: COG0308 Aminopeptidase N; Psort location: cytoplasmic, score: 23 YP_001438491.1 Psort location: cytoplasmic, score: 23 YP_001438492.1 catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate YP_001438493.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001438494.1 Psort location: cytoplasmic, score: 23 YP_001438495.1 COG: COG3203 Outer membrane protein (porin); Psort location: extracellular, including cell wall, score: 9 YP_001438496.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate YP_001438497.1 KEGG: eci:UTI89_C0999 1.1e-104 ycbL; hypothetical protein K01069; COG: COG0491 Zn-dependent hydrolases, including glyoxylases; Psort location: extracellular, including cell wall, score: 9 YP_001438498.1 COG: COG3108 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001438499.1 COG: COG2989 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001438500.1 SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects YP_001438501.1 acts with MukB and MukF to condense the chromosome and allow for segregation during cell division YP_001438502.1 acts with MukB and MukE to condense the chromosome and allow for segregation during cell division YP_001438503.1 involved in cellular zinc and cadmium homeostasis by binding excess metal ions to its cysteine sulfurs and histidine nitrogens; expression of smtA in cyanobacteria is repressed by SmtB at low concentrations of zinc; NO elicits release of Zn ions from SmtA YP_001438504.1 COG: COG1434 Uncharacterized conserved protein; Psort location: extracellular, including cell wall, score: 9 YP_001438505.1 COG: NOG06195 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001438506.1 COG: NOG14690 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001438507.1 COG: COG1522 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001438508.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS YP_001438509.1 KEGG: net:Neut_2110 1.2e-15 tetraacyldisaccharide 4'-kinase K00912; COG: COG2835 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001438510.1 COG: COG3214 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001438511.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate YP_001438512.1 involved in the transport of lipid A across the inner membrane YP_001438513.1 COG: COG0658 Predicted membrane metal-binding protein; Psort location: plasma membrane, score: 23 YP_001438514.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_001438515.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_001438516.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP YP_001438517.1 Psort location: cytoplasmic, score: 23 YP_001438518.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_001438519.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine YP_001438520.1 KEGG: mmp:MMP0248 0.0028 DNA-directed RNA polymerase related protein K03059; COG: COG2323 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001438521.1 COG: COG1944 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001438522.1 KEGG: shn:Shewana3_1556 2.1e-74 meTHIonine gamma-lyase K01761; COG: COG2116 Formate/nitrite family of transporters; Psort location: endoplasmic reticulum, score: 9 YP_001438523.1 KEGG: stm:STM0973 0. pflB; pyruvate formate lyase I K00656; COG: COG1882 Pyruvate-formate lyase; Psort location: cytoplasmic, score: 23 YP_001438524.1 Psort location: cytoplasmic, score: 23 YP_001438525.1 activates pyruvate formate-lyase 1 under anaerobic conditions YP_001438526.1 KEGG: eci:UTI89_C5041 8.4e-07 yjiJ; hypothetical protein YjiJ K00403; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: endoplasmic reticulum, score: 23 YP_001438527.1 Psort location: cytoplasmic, score: 23 YP_001438528.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001438529.1 KEGG: pha:PSHAa1714 4.9e-139 rarA; polynucleotide enzyme with nucleotide triphosphate hydrolase domain K07478; COG: COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase; Psort location: cytoplasmic, score: 23 YP_001438530.1 participates with LolB in the incorporation of lipoprotein into the outer membrane YP_001438531.1 KEGG: pen:PSEEN2212 1.7e-186 ftsK; cell division protein FtsK; COG: COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins; Psort location: endoplasmic reticulum, score: 9 YP_001438532.1 mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system YP_001438533.1 catalyzes the transfer of electrons from NADPH to thioredoxin; FAD/NAD(P) binding YP_001438534.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c YP_001438535.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c YP_001438536.1 KEGG: spt:SPA1843 7.9e-84 aat; leucyl/phenylalanyl-tRNA-protein transferase K00684; COG: COG2360 Leu/Phe-tRNA-protein transferase; Psort location: cytoplasmic, score: 23 YP_001438537.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_001438538.1 ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease; directs protease to specific substrates YP_001438539.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA YP_001438540.1 COG: COG1278 Cold shock proteins; Psort location: cytoplasmic, score: 23 YP_001438541.1 with MacA is involved in the export of macrolide YP_001438542.1 confers macrolide resistance via active drug efflux YP_001438543.1 COG: COG2990 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001438544.1 COG: COG3593 Predicted ATP-dependent endonuclease of the OLD family; Psort location: cytoplasmic, score: 23 YP_001438545.1 COG: COG2431 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001438546.1 catalyzes the reduction of hydroxylamine to ammonia and water YP_001438547.1 KEGG: eci:UTI89_C0875 3.7e-141 hcr; NADH oxidoreductase; COG: COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1; Psort location: cytoplasmic, score: 23 YP_001438548.1 catalyzes the formation of acetate from pyruvate YP_001438549.1 low- specificity; catalyzes the formation of acetaldehyde and glycine from L-threonine; acts on L-threonine, L-allo-threonine, L-threo-phenylserine, and L-erythro-phenylserine YP_001438550.1 KEGG: eci:UTI89_C0871 1.8e-155 ybjS; hypothetical protein YbjS K00067; COG: COG0451 Nucleoside-diphosphate-sugar epimerases; Psort location: cytoplasmic, score: 23 YP_001438551.1 KEGG: ecs:ECs0953 8.9e-108 N-acetylmuramoyl-L-alanine amidase K01446; COG: COG3023 Negative regulator of beta-lactamase expression; Psort location: extracellular, including cell wall, score: 9 YP_001438552.1 COG: COG0393 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001438553.1 induced during stationary phase and by acivicin (a glutamine analog); regulated by Lrp and RpoS YP_001438554.1 With ArtMQJI transports arginine across the inner membrane YP_001438555.1 KEGG: eci:UTI89_C2121 1.0e-28 fliY; cystine-binding periplasmic protein precursor K02030:K02424; COG: COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; Psort location: extracellular, including cell wall, score: 9 YP_001438556.1 with ArtPMJI transports arginine across the inner membrane YP_001438557.1 with ArtPQJI acts to transport arginine across the inner membrane YP_001438558.1 Psort location: cytoplasmic, score: 23 YP_001438559.1 KEGG: eci:UTI89_C2121 4.3e-28 fliY; cystine-binding periplasmic protein precursor K02030:K02424; COG: COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; Psort location: endoplasmic reticulum, score: 9 YP_001438560.1 RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA YP_001438561.1 COG: NOG08677 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001438562.1 KEGG: cya:CYA_1846 4.0e-14 modB; molybdate ABC transporter, permease protein K02018; COG: COG1177 ABC-type spermidine/putrescine transport system, permease component II; Psort location: plasma membrane, score: 23 YP_001438563.1 KEGG: hpa:HPAG1_0451 2.1e-09 molybdenum ABC transporter ModB K06022; COG: COG1176 ABC-type spermidine/putrescine transport system, permease component I; Psort location: endoplasmic reticulum, score: 9 YP_001438564.1 part of the PotFGHI ATP-dependent putrescine transporter YP_001438565.1 COG: COG0687 Spermidine/putrescine-binding periplasmic protein; Psort location: cytoplasmic, score: 23 YP_001438566.1 COG: NOG08676 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001438567.1 KEGG: mes:Meso_3585 3.2e-16 glutathione synthetase K01920; COG: COG0189 glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase); Psort location: cytoplasmic, score: 23 YP_001438568.1 NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds YP_001438569.1 COG: NOG09759 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001438570.1 COG: COG2985 Predicted permease; Psort location: plasma membrane, score: 23 YP_001438571.1 Psort location: golgi, score: 9 YP_001438572.1 Psort location: endoplasmic reticulum, score: 9 YP_001438573.1 COG: COG3226 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001438574.1 KEGG: eci:UTI89_C5041 4.7e-05 yjiJ; hypothetical protein YjiJ K00403; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001438575.1 COG: COG1344 Flagellin and related hook-associated proteins; Psort location: nuclear, score: 23 YP_001438576.1 KEGG: sbo:SBO_0712 3.6e-72 hypothetical protein K07757; COG: COG0561 Predicted hydrolases of the HAD superfamily; Psort location: cytoplasmic, score: 23 YP_001438577.1 KEGG: shn:Shewana3_1692 1.2e-05 Xaa-His dipeptidase K01270; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001438578.1 COG: COG3907 PAP2 (acid phosphatase) superfamily protein; Psort location: endoplasmic reticulum, score: 23 YP_001438579.1 KEGG: btk:BT9727_2194 3.1e-11 probable phosphatase, PAP2 superfamily; possible bacitracin transport permease K01112; COG: COG0671 Membrane-associated phospholipid phosphatase; Psort location: endoplasmic reticulum, score: 9 YP_001438580.1 COG: COG1349 Transcriptional regulators of sugar metabolism; Psort location: cytoplasmic, score: 23 YP_001438581.1 penicillin-binding protein 6a; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains YP_001438582.1 KEGG: eci:UTI89_C0841 8.2e-82 yliJ; hypothetical GST-like protein YliJ K00799; COG: COG0625 glutathione S-transferase; Psort location: cytoplasmic, score: 23 YP_001438583.1 KEGG: azo:azo1253 1.3e-76 conserved hypothetical protein K00117; COG: COG2133 Glucose/sorbosone dehydrogenases; Psort location: endoplasmic reticulum, score: 9 YP_001438584.1 catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit YP_001438585.1 KEGG: rha:RHA1_ro09047 7.9e-05 ABC peptide transporter, permease component K02033; COG: COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001438586.1 KEGG: rha:RHA1_ro09047 1.7e-42 ABC peptide transporter, permease component K02033; COG: COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001438587.1 KEGG: shn:Shewana3_2650 3.9e-30 acetate kinase K00925; COG: COG0747 ABC-type dipeptide transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001438588.1 with GsiBCD is involved in glutathione import; GsiA contains 2 ATP-binding domains YP_001438589.1 Psort location: nuclear, score: 23 YP_001438590.1 is involved in the formation of active molybdenum cofactor and the chelation of molybdenum YP_001438591.1 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase YP_001438592.1 COG: COG1609 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001438593.1 KEGG: dre:30298 0.0020 jak2b; Janus kinase 2b K04447; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001438594.1 KEGG: ssn:SSO_0800 0. putative glucosidase K01187; COG: COG1501 Alpha-glucosidases, family 31 of glycosyl hydrolases; Psort location: cytoplasmic, score: 23 YP_001438595.1 Psort location: nuclear, score: 23 YP_001438596.1 Psort location: cytoplasmic, score: 23 YP_001438597.1 KEGG: eci:UTI89_C4946 3.1e-66 putative member of ShlA/HecA/FhaA exoprotein family; COG: COG3210 Large exoproteins involved in heme utilization or adhesion; Psort location: nuclear, score: 23 YP_001438598.1 KEGG: eci:UTI89_C0824 8.7e-268 ybiT; hypothetical ABC transporter ATP-binding protein YbiT K01957; COG: COG0488 ATPase components of ABC transporters with duplicated ATPase domains; Psort location: cytoplasmic, score: 23 YP_001438599.1 KEGG: eci:UTI89_C2228 3.3e-101 erfK; hypothetical protein K00257; COG: COG1376 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001438600.1 KEGG: hdu:HD1819 0.0039 dnaX; DNA polymerase III subunits gamma and tau K02343; COG: COG1538 Outer membrane protein; Psort location: extracellular, including cell wall, score: 9 YP_001438601.1 KEGG: sgl:SG1466 1.9e-10 dethiobiotinsynthase K01935; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001438602.1 KEGG: lpp:lpp3057 0.0033 atpF; F-type H+-transporting ATPase b chain K02109; COG: COG1566 Multidrug resistance efflux pump; Psort location: endoplasmic reticulum, score: 9 YP_001438603.1 COG: COG0471 Di- and tricarboxylate transporters; Psort location: plasma membrane, score: 23 YP_001438604.1 Transcriptional regulator that represses the manganese transporter MntH when manganese is present YP_001438605.1 Psort location: extracellular, including cell wall, score: 9 YP_001438606.1 KEGG: eci:UTI89_C0819 1.5e-222 ybiP; hypothetical protein YbiP K00924; COG: COG2194 Predicted membrane-associated, metal-dependent hydrolase; Psort location: endoplasmic reticulum, score: 9 YP_001438607.1 OmpX; involved in cell adhesion; forms an eight-stranded antiparallel beta-barrel that protrudes from the cell surface; mutations in the gene increase cell-surface contact in fimbriated strains but decrease contact in nonfimbriated strains YP_001438608.1 KEGG: pae:PA1977 4.6e-09 sensor protein GLPS; COG: COG5006 Predicted permease, DMT superfamily; Psort location: plasma membrane, score: 23 YP_001438609.1 binds DNA in a non-sequence-specific manner and is abundant during stationary phase; forms a DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage YP_001438610.1 similar to periplasmic-binding component of ABC transporters YP_001438611.1 similar to permease component of ABC transporters; mutations impair ability of Escherichia coli to transport and utilize glutamine YP_001438612.1 similar to ATP-binding component of ABC transporters YP_001438613.1 COG: COG0668 Small-conductance mechanosensitive channel; Psort location: plasma membrane, score: 23 YP_001438614.1 KEGG: vfi:VFA1153 4.0e-80 methyltransferase; COG: COG3129 Predicted SAM-dependent methyltransferase; Psort location: cytoplasmic, score: 23 YP_001438615.1 KEGG: bmf:BAB1_1090 1.8e-38 nitrilotriacetate monooxygenase component B K00492; COG: COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family; Psort location: cytoplasmic, score: 23 YP_001438616.1 COG: COG1734 DnaK suppressor protein; Psort location: nuclear, score: 23 YP_001438617.1 COG: NOG13870 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001438618.1 KEGG: rso:RSc0378 6.0e-54 trpD3, RS03346; putative anthranilate phosphoribosyltransferase protein K00766; COG: COG0547 Anthranilate phosphoribosyltransferase; Psort location: cytoplasmic, score: 23 YP_001438619.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001438620.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: extracellular, including cell wall, score: 9 YP_001438621.1 COG: COG3188 P pilus assembly protein, porin PapC; Psort location: nuclear, score: 23 YP_001438622.1 KEGG: chu:CHU_1335 0.0090 CHU large protein; endoglucanase-related protein, glucosyl hydrolase family 9 protein K01238; COG: NOG23921 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001438623.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001438624.1 helicase involved in DNA repair and perhaps also replication YP_001438625.1 COG: COG3711 Transcriptional antiterminator; Psort location: cytoplasmic, score: 23 YP_001438626.1 KEGG: bsu:BG10934 6.0e-157 bglP, sytA, n17C; PTS beta-glucoside-specific enzyme IIBCA component K02755:K02756:K02757; COG: COG2190 Phosphotransferase system IIA components; Psort location: plasma membrane, score: 23 YP_001438627.1 KEGG: lin:lin0288 1.6e-156 beta-glucosidase K01188; COG: COG2723 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase; Psort location: cytoplasmic, score: 23 YP_001438628.1 KEGG: bsu:BG10935 1.8e-148 bglH, n17D; beta-glucosidase K01188; COG: COG2723 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase; Psort location: cytoplasmic, score: 23 YP_001438629.1 this helicase is not essential cell growth YP_001438630.1 COG: COG1309 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001438631.1 COG: COG0845 Membrane-fusion protein; Psort location: mitochondrial, score: 23 YP_001438632.1 KEGG: rru:Rru_A1792 1.1e-166 ABC transporter component K01990; COG: COG1131 ABC-type multidrug transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001438633.1 KEGG: fal:FRAAL1796 1.8e-12 putative ABC transporter ATP-binding subunit; COG: COG0842 ABC-type multidrug transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001438634.1 KEGG: fal:FRAAL1796 1.1e-11 putative ABC transporter ATP-binding subunit; COG: COG0842 ABC-type multidrug transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001438635.1 COG: NOG09757 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001438636.1 KEGG: eci:UTI89_C0791 1.2e-121 ybhP; putative DNase; COG: COG3568 Metal-dependent hydrolase; Psort location: mitochondrial, score: 23 YP_001438637.1 KEGG: spt:SPA1941 9.1e-186 ybhO; putative phospholipase K06132; COG: COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipi n synthases and related enzymes; Psort location: cytoplasmic, score: 23 YP_001438638.1 COG: COG0392 Predicted integral membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001438639.1 COG: COG0670 Integral membrane protein, interacts with FtsH; Psort location: plasma membrane, score: 23 YP_001438640.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin YP_001438641.1 COG: COG1977 Molybdopterin converting factor, small subunit; Psort location: cytoplasmic, score: 23 YP_001438642.1 COG: COG0315 Molybdenum cofactor biosynthesis enzyme; Psort location: cytoplasmic, score: 23 YP_001438643.1 KEGG: mtu:Rv0984 1.9e-11 moaB2; possible pterin-4-alpha-carbinolamine dehydratase MoaB2 (PHS) (4-alpha-hydroxy-tetrahydropterin dehydratase) (pterin-4-A-carbinolamine dehydratase) (phenylalanine hydroxylase-stimulating protein) (PHS) (pterin carbinolamine dehydratase) (PCD); COG: COG0521 Molybdopterin biosynthesis enzymes; Psort location: cytoplasmic, score: 23 YP_001438644.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z YP_001438645.1 Psort location: mitochondrial, score: 23 YP_001438646.1 KEGG: nph:NP2028A 1.4e-05 hypothetical protein K00924; COG: COG0391 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001438647.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_001438648.1 Psort location: nuclear, score: 23 YP_001438649.1 KEGG: reh:H16_A1079 7.5e-40 ABC-type transporter, ATPase component: HAAT family; COG: COG0410 ABC-type branched-chain amino acid transport systems, ATPase component; Psort location: cytoplasmic, score: 23 YP_001438650.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium YP_001438651.1 putative methyltransferase; acyl carrier protein involved in an unidentified step in the synthesis of pimeloyl-CoA, a biotin precursor; member of the bio operon (bioABFCD); in Escherichia coli, bioC-null mutants require biotin for growth YP_001438652.1 KEGG: sbo:SBO_0663 1.0e-129 bioF; 8-amino-7-oxononanoate synthase K00652; COG: COG0156 7-keto-8-aminopelargonate synthetase and related enzymes; Psort location: endoplasmic reticulum, score: 9 YP_001438653.1 KEGG: ecc:c0855 1.8e-173 bioB; biotin synthase K01012; COG: COG0502 Biotin synthase and related enzymes; Psort location: cytoplasmic, score: 23 YP_001438654.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate YP_001438655.1 KEGG: psp:PSPPH_3239 8.8e-85 ThiJ/PfpI family protein K01423; COG: COG0693 Putative intracellular protease/amidase; Psort location: cytoplasmic, score: 23 YP_001438656.1 YbhB; similar to rat and human kinase inhibitory proteins YP_001438657.1 outer membrane lipoprotein that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; YbhC localizes to the cellular poles; member of pectinesterase family YP_001438658.1 catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate YP_001438659.1 YbhA; catalyzes the dephosphorylation of pyridoxal phosphate, fructose 1,6-bisphosphate, erythrose 4-phosphate and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; phosphotransferase activity observed when using monophosphates as phosphate donor; member of the haloacid dehalogenase-like hydrolases superfamily YP_001438660.1 Part of the ABC transporter complex modABC involved in molybdenum import YP_001438661.1 part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE YP_001438662.1 with ModCB is involved in the high-affinity transport of molybdate YP_001438663.1 COG: NOG17580 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001438664.1 represses the modABCD operon and activates the moaABCD and napFDAGHBC operons YP_001438665.1 Psort location: nuclear, score: 23 YP_001438666.1 contains 2 ATP-binding cassettes; involved in the transport of molybdenum YP_001438667.1 KEGG: stm:STM0776 2.3e-171 galE; UDP-galactose 4-epimerase K01784; COG: COG1087 UDP-glucose 4-epimerase; Psort location: cytoplasmic, score: 23 YP_001438668.1 catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P YP_001438669.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism YP_001438670.1 catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose YP_001438671.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate YP_001438672.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive YP_001438673.1 KEGG: cal:orf19.4072 2.0e-08 HYR10; similar to cell surface flocculin K01186; COG: NOG09755 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001438674.1 Psort location: endoplasmic reticulum, score: 9 YP_001438675.1 involved in zinc efflux across the cytoplasmic membrane YP_001438676.1 COG: COG3201 Nicotinamide mononucleotide transporter; Psort location: plasma membrane, score: 23 YP_001438677.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate YP_001438678.1 periplasmic protein that interacts with TolA; the tol-pal system is probably involved in maintaining cell envelope integrity YP_001438679.1 Psort location: cytoplasmic, score: 23 YP_001438680.1 KEGG: bxe:Bxe_A4171 1.5e-07 putative cytochrome c oxidase K00403; COG: COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins; Psort location: nuclear, score: 23 YP_001438681.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA YP_001438682.1 inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins YP_001438683.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins YP_001438684.1 Psort location: cytoplasmic, score: 23 YP_001438685.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins YP_001438686.1 catalyzes the hydrolysis of short chain aliphatic acyl-CoA thioesters; physiological role remains unknown; involved in phospholipid metabolism; part of the Tol/Pal system of proteins that are critical for maintaining the integrity of the cell envelope components YP_001438687.1 COG: COG3790 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001438688.1 COG: COG4890 Predicted outer membrane lipoprotein; Psort location: extracellular, including cell wall, score: 9 YP_001438689.1 KEGG: spt:SPA2002 1.0e-184 cydB; cytochrome d ubiquinol oxidase subunit II K00426; COG: COG1294 Cytochrome bd-type quinol oxidase, subunit 2; Psort location: plasma membrane, score: 23 YP_001438690.1 KEGG: ece:Z0900 8.5e-261 cydA; cytochrome d terminal oxidase, polypeptide subunit I K00425; COG: COG1271 Cytochrome bd-type quinol oxidase, subunit 1; Psort location: plasma membrane, score: 23 YP_001438691.1 Psort location: cytoplasmic, score: 23 YP_001438692.1 KEGG: lmf:LMOf2365_0421 4.7e-141 glycosyl hydrolase, family 38 K01191; COG: COG0383 Alpha-mannosidase; Psort location: cytoplasmic, score: 23 YP_001438693.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake YP_001438694.1 regulates the succiny-lCoA synthetase operon YP_001438695.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle YP_001438696.1 catalyzes the interconversion of succinyl-CoA and succinate YP_001438697.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA YP_001438698.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide YP_001438699.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase YP_001438700.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol YP_001438701.1 KEGG: ssn:SSO_0673 1.3e-49 sdhD; succinate dehydrogenase, hydrophobic subunit K00242; COG: COG2142 Succinate dehydrogenase, hydrophobic anchor subunit; Psort location: endoplasmic reticulum, score: 9 YP_001438702.1 KEGG: spt:SPA2011 5.4e-53 sdhC; succinate dehydrogenase cytochrome b-556 subunit K00241; COG: COG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit; Psort location: endoplasmic reticulum, score: 9 YP_001438703.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH YP_001438704.1 5-formyluracil/5-hydroxymethyluracil DNA glycosylase; involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases with a preference for oxidized pyrimidines; has apurinic/apyrimidinic lyase activity YP_001438705.1 COG: NOG06103 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001438706.1 COG: COG3817 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001438707.1 COG: COG3819 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001438708.1 Psort location: nuclear, score: 23 YP_001438709.1 COG: COG5631 Predicted transcription regulator, contains HTH domain (MarR family); Psort location: cytoplasmic, score: 23 YP_001438710.1 COG: COG1540 Uncharacterized proteins, homologs of lactam utilization protein B; Psort location: cytoplasmic, score: 23 YP_001438711.1 KEGG: eci:UTI89_C0710 5.3e-126 ybgK; hypothetical protein K01941; COG: COG1984 Allophanate hydrolase subunit 2; Psort location: cytoplasmic, score: 23 YP_001438712.1 KEGG: eci:UTI89_C0709 3.0e-84 ybgJ; hypothetical protein YbgJ K01457; COG: COG2049 Allophanate hydrolase subunit 1; Psort location: cytoplasmic, score: 23 YP_001438713.1 COG: COG0327 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001438714.1 UV-induced DNA repair; converts cyclobutane-type pyrimidine dimers created during exposure to UV ratiation to monomers; light dependent YP_001438715.1 KEGG: ctc:CTC02272 9.7e-08 purine nucleoside phosphorylase K00755; COG: COG3272 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001438716.1 COG: NOG13868 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001438717.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions YP_001438718.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions YP_001438719.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex YP_001438720.1 sensory histidine kinase in two-component regulatory system with KdpE; signal sensing protein YP_001438721.1 KEGG: eci:UTI89_C0698 2.2e-97 kdpE; transcriptional regulatory protein KdpE K07667; COG: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; Psort location: cytoplasmic, score: 23 YP_001438722.1 KEGG: ssn:SSO_0644 0. speF; orniTHIne decarboxylase isozyme, inducible K01581; COG: COG1982 Arginine/lysine/orniTHIne decarboxylases; Psort location: cytoplasmic, score: 23 YP_001438723.1 catalyzes the uptake of putrescine via a proton symport mechanism, as well as the efflux of putrescine by a putrescine/ornithine antiport system YP_001438724.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate YP_001438725.1 negative modulator of the initiation of chromosome replication YP_001438726.1 KEGG: spt:SPA2045 2.8e-104 ybfF; putative esterase/lipase YbfF; COG: COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily); Psort location: cytoplasmic, score: 23 YP_001438727.1 COG: NOG13544 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001438728.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_001438729.1 negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer YP_001438730.1 COG: NOG06782 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001438731.1 KEGG: yps:YPTB1123 0. beta-N-acetylhexosaminidase K01207; COG: COG3525 N-acetyl-beta-hexosaminidase; Psort location: cytoplasmic, score: 23 YP_001438732.1 KEGG: psp:PSPPH_3782 9.5e-12 porin D; COG: NOG06287 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001438733.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001438734.1 Psort location: cytoplasmic, score: 23 YP_001438735.1 Psort location: extracellular, including cell wall, score: 9 YP_001438736.1 KEGG: yps:YPTB1120 8.3e-279 nagE, pstN; PTS system, N-acetylglucosamine-specific IIABC component K02802:K02803:K02804; COG: COG2190 Phosphotransferase system IIA components; Psort location: endoplasmic reticulum, score: 9 YP_001438737.1 catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate YP_001438738.1 catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate YP_001438739.1 KEGG: eci:UTI89_C0670 1.1e-187 nagC; transcriptional repressor of nag (N-acetylglucosamine) operon K02565; COG: COG1940 Transcriptional regulator/sugar kinase; Psort location: cytoplasmic, score: 23 YP_001438740.1 KEGG: eci:UTI89_C0669 3.2e-126 nagD; N-acetylglucosamine metabolism K02566; COG: COG0647 Predicted sugar phosphatases of the HAD superfamily; Psort location: cytoplasmic, score: 23 YP_001438741.1 functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP YP_001438743.1 catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; functions in the biosynthesis of ubiquinone or coenzyme Q YP_001438744.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) YP_001438745.1 KEGG: reh:H16_A0527 2.0e-85 phoH; phosphate starvation-inducible protein PhoH,predicted ATPase; COG: COG1702 Phosphate starvation-inducible protein PhoH, predicted ATPase; Psort location: cytoplasmic, score: 23 YP_001438746.1 KEGG: dps:DP1605 1.5e-08 probable pyridoxal phosphate biosynthetic protein K03474; COG: COG0319 Predicted metal-dependent hydrolase; Psort location: cytoplasmic, score: 23 YP_001438747.1 KEGG: eci:UTI89_C0656 2.5e-142 ybeX; putative transport protein K06189; COG: COG4535 Putative Mg2+ and Co2+ transporter CorC; Psort location: cytoplasmic, score: 23 YP_001438748.1 Transfers the fatty acyl group on membrane lipoproteins YP_001438749.1 KEGG: bur:Bcep18194_A4762 2.1e-21 ABC amino acid transporter, periplasmic ligand binding protein K01713; COG: COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; Psort location: cytoplasmic, score: 23 YP_001438750.1 KEGG: eca:ECA0855 2.7e-19 ABC transporter permease protein K02028; COG: COG0765 ABC-type amino acid transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001438751.1 KEGG: sma:SAV6546 5.7e-26 putative ABC transporter permease K02028; COG: COG0765 ABC-type amino acid transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001438752.1 KEGG: stt:t2211 6.2e-116 gltL; glutamate/aspartate transport ATP-binding protein GltL K02028; COG: COG1126 ABC-type polar amino acid transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001438753.1 COG: NOG08739 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001438754.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_001438755.1 COG: COG2980 Rare lipoprotein B; Psort location: nuclear, score: 23 YP_001438756.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA YP_001438757.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria YP_001438758.1 KEGG: bba:Bd3846 5.6e-10 probable nicotinate-nucleotide adenylyltransferase K00969; COG: COG0799 Uncharacterized homolog of plant Iojap protein; Psort location: mitochondrial, score: 23 YP_001438759.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA YP_001438760.1 KEGG: eci:UTI89_C0637 0. mrdA; cell elongation, e phase; peptidoglycan synthetase; penicillin-binding protein 2 K05515; COG: COG0768 Cell division protein FtsI/penicillin-binding protein 2; Psort location: cytoplasmic, score: 23 YP_001438761.1 COG: COG0772 Bacterial cell division membrane protein; Psort location: plasma membrane, score: 23 YP_001438762.1 KEGG: ret:RHE_CH01819 5.8e-06 hypothetical protein K01238; COG: COG0797 Lipoproteins; Psort location: extracellular, including cell wall, score: 9 YP_001438763.1 penicillin-binding protein 5; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors YP_001438764.1 COG: COG2921 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001438765.1 Psort location: nuclear, score: 23 YP_001438766.1 KEGG: eci:UTI89_C0632 4.2e-78 lipB; lipoate-protein ligase B K03801; COG: COG0321 Lipoate-protein ligase B; Psort location: cytoplasmic, score: 23 YP_001438767.1 COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001438768.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_001438769.1 TatE; similar to TatA and found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes YP_001438770.1 KEGG: eci:UTI89_C0629 1.6e-94 ybeM; putative amidase K01501; COG: COG0388 Predicted amidohydrolase; Psort location: cytoplasmic, score: 23 YP_001438771.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling YP_001438772.1 member of the CspA family; constitutively expressed RNA/ssDNA-binding protein; functions in helping cells adapt to low temperature; aids nucleic acid melting; participates in gene regulation; can act as a transcription antiterminator YP_001438773.1 catalyzes the transfer of palmitate to lipid A YP_001438774.1 responsible for the transport of C4-dicarboxylates during anaerobic growth YP_001438775.1 KEGG: ssn:SSO_0563 9.5e-104 rna; RNase I K01169; COG: COG3719 Ribonuclease I; Psort location: extracellular, including cell wall, score: 9 YP_001438776.1 COG: NOG18344 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001438777.1 KEGG: bba:Bd2279 8.4e-199 malA; alpha-D-1,4-glucosidase K01187; COG: COG0366 Glycosidases; Psort location: cytoplasmic, score: 23 YP_001438778.1 KEGG: vvy:VVA0760 2.0e-204 glycosidase K01182; COG: COG0366 Glycosidases; Psort location: cytoplasmic, score: 23 YP_001438779.1 KEGG: vvu:VV2_1584 1.2e-101 ABC-type sugar transport system, ATPase component K02023; COG: COG3839 ABC-type sugar transport systems, ATPase components; Psort location: cytoplasmic, score: 23 YP_001438780.1 KEGG: cdi:DIP0495 4.3e-05 putative molybdenum ABC transport system (integral membrane and ATP-binding proteins) K02017:K02018; COG: COG0395 ABC-type sugar transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001438781.1 KEGG: pac:PPA0505 4.5e-08 ABC transporter, putative molybdenum transport system K02017:K02018; COG: COG1175 ABC-type sugar transport systems, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001438782.1 COG: COG1653 ABC-type sugar transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001438783.1 KEGG: eci:UTI89_C3106 9.6e-79 ygbN; hypothetical permease YgbN K03299; COG: COG2610 H+/gluconate symporter and related permeases; Psort location: plasma membrane, score: 23 YP_001438784.1 Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation YP_001438785.1 KEGG: pst:PSPTO_1875 6.1e-164 fdH; glutathione-dependent formaldehyde dehydrogenase K00121; COG: COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases; Psort location: endoplasmic reticulum, score: 9 YP_001438786.1 COG: COG0589 Universal stress protein UspA and related nucleotide-binding proteins; Psort location: cytoplasmic, score: 23 YP_001438787.1 KEGG: ecp:ECP_0639 3.4e-257 alkyl hydroperoxide reductase subunit F K03387; COG: COG3634 Alkyl hydroperoxide reductase, large subunit; Psort location: cytoplasmic, score: 23 YP_001438788.1 with AhpF catalyzes the conversion of alkyl hydroperoxides to their corresponding alcohols; AhpC reduced the hydroperoxide substrate YP_001438789.1 Psort location: cytoplasmic, score: 23 YP_001438790.1 KEGG: shn:Shewana3_3435 7.7e-08 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001438791.1 catalyzes the transfer of an amino moiety YP_001438792.1 catalyzes the formation of diketo methylthiopentyl phosphate from methylribulose phosphate in the methionine salvage pathway YP_001438793.1 KEGG: gbe:GbCGDNIH1_2267 2.5e-48 2,3-diketo-5-methylTHIo-1-phosphopentanoate tautomerase K01112; COG: COG4229 Predicted enolase-phosphatase; Psort location: cytoplasmic, score: 23 YP_001438794.1 KEGG: psp:PSPPH_1815 7.1e-51 ARD/ARD'''' family protein K05915; COG: COG1791 Uncharacterized conserved protein, contains double-stranded beta-helix domain; Psort location: cytoplasmic, score: 23 YP_001438795.1 with EntB, EntD, and EntE forms the multienzyme complex enterobactin synthase; EntF is the serine activating enzyme which catalyzes the formation of the amide and ester bonds of the cyclic enterobactin YP_001438796.1 COG: COG3251 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001438797.1 KEGG: btk:BT9727_2470 7.7e-15 probable esterase K07214; COG: COG2382 Enterochelin esterase and related enzymes; Psort location: cytoplasmic, score: 23 YP_001438798.1 Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space YP_001438799.1 KEGG: stt:t2284 1.7e-40 entD; enterobactin synthetase component D K02362; COG: COG2977 Phosphopantetheinyl transferase component of siderophore synthetase; Psort location: cytoplasmic, score: 23 YP_001438800.1 KEGG: bme:BMEII0002 1.5e-48 ribosomal-protein-serine acetyltransferase K00680; COG: COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins; Psort location: cytoplasmic, score: 23 YP_001438801.1 ATP-dependent; carboxylate-amine ligase with weak glutamate--cysteine ligase activity YP_001438802.1 KEGG: pca:Pcar_2344 3.4e-06 nitrogen regulation protein NtrY, putative; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 9 YP_001438803.1 COG: COG3518 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001438804.1 COG: COG4455 Protein of avirulence locus involved in temperature-dependent protein secretion; Psort location: cytoplasmic, score: 23 YP_001438805.1 COG: NOG25930 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001438806.1 KEGG: cal:orf19.4072 0.0053 HYR10; similar to cell surface flocculin K01186; COG: NOG22390 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001438807.1 KEGG: ago:ADR086C 1.1e-09 ADR086Cp; DNA-directed RNA polymerase II subunit A K03006; COG: COG3501 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001438808.1 KEGG: eci:UTI89_C0735 0.00070 tolA; membrane spanning protein TolA K03646; Psort location: cytoplasmic, score: 23 YP_001438809.1 COG: COG2369 Uncharacterized protein, homolog of phage Mu protein gp30; Psort location: nuclear, score: 23 YP_001438810.1 Psort location: cytoplasmic, score: 23 YP_001438811.1 COG: COG1783 Phage terminase large subunit; Psort location: cytoplasmic, score: 23 YP_001438812.1 Psort location: nuclear, score: 23 YP_001438813.1 Psort location: cytoplasmic, score: 23 YP_001438814.1 KEGG: ecs:ECs1623 1.0e-33 putative endopeptidase K01423; COG: NOG19968 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001438815.1 KEGG: yps:YPTB1805 2.9e-47 probable endolysin (lysis protein) (lysozyme) K01185; COG: COG3772 Phage-related lysozyme (muraminidase); Psort location: endoplasmic reticulum, score: 9 YP_001438816.1 Psort location: cytoplasmic, score: 23 YP_001438817.1 Psort location: cytoplasmic, score: 23 YP_001438818.1 COG: NOG09845 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001438819.1 Psort location: nuclear, score: 23 YP_001438820.1 Psort location: cytoplasmic, score: 23 YP_001438821.1 KEGG: sec:SC0344 5.9e-24 rusA; Rus K01160; COG: COG4570 Holliday junction resolvase; Psort location: cytoplasmic, score: 23 YP_001438822.1 COG: COG0582 Integrase; Psort location: cytoplasmic, score: 23 YP_001438823.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate YP_001438824.1 COG: COG2501 Uncharacterized conserved protein; Psort location: extracellular, including cell wall, score: 9 YP_001438825.1 KEGG: gka:GK0991 5.6e-122 PTS system, glucose-specific enzyme II, A component K02763:K02764:K02765; COG: COG2190 Phosphotransferase system IIA components; Psort location: plasma membrane, score: 23 YP_001438826.1 KEGG: efa:EF1922 3.1e-06 transcriptional regulator, LacI family/carbohydrate kinase, PfkB family protein K00852; COG: COG1609 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001438827.1 KEGG: eci:UTI89_C0555 4.7e-228 cysS; cysteinyl-tRNA synthetase (cysteine--tRNA ligase) K01883; COG: COG0215 Cysteinyl-tRNA synthetase; Psort location: cytoplasmic, score: 23 YP_001438828.1 Psort location: cytoplasmic, score: 23 YP_001438829.1 KEGG: eci:UTI89_C0554 2.6e-85 ppiB; peptidyl-prolyl cis-trans isomerase B (rotamase B) K03768; COG: COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family; Psort location: cytoplasmic, score: 23 YP_001438830.1 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine YP_001438831.1 KEGG: stt:t2327 2.4e-73 purE; phosphoribosylaminoimidazole carboxylase catalytic subunit K01588; COG: COG0041 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase; Psort location: cytoplasmic, score: 23 YP_001438832.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway YP_001438833.1 KEGG: plu:plu0523 5.5e-147 unnamed protein product; similar to cystathionine gamma-lyase K01758; COG: COG0626 cystathionine beta-lyases/cystathionine gamma-synthases; Psort location: cytoplasmic, score: 23 YP_001438834.1 KEGG: plu:plu0524 1.0e-163 unnamed protein product; similar to cystathionine beta-synthase K01697; COG: COG0031 Cysteine synthase; Psort location: cytoplasmic, score: 23 YP_001438835.1 Psort location: mitochondrial, score: 23 YP_001438836.1 catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA YP_001438837.1 COG: COG3127 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component; Psort location: plasma membrane, score: 23 YP_001438838.1 KEGG: pen:PSEEN1885 4.6e-56 ABC transporter, ATP-binding protein; COG: COG4181 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component; Psort location: cytoplasmic, score: 23 YP_001438839.1 KEGG: eci:UTI89_C0529 3.2e-96 tesA; acyl-CoA THIoesterase I precursor K01048:K01076; COG: COG2755 Lysophospholipase L1 and related esterases; Psort location: extracellular, including cell wall, score: 23 YP_001438840.1 KEGG: ecc:c0614 1.2e-110 ybbO; short chain dehydrogenase; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001438841.1 KEGG: eci:UTI89_C0527 6.2e-123 ybbN; putative THIoredoxin-like protein K05838; COG: COG3118 Thioredoxin domain-containing protein; Psort location: cytoplasmic, score: 23 YP_001438842.1 KEGG: reh:H16_A2036 1.7e-56 membrane protease subunits, stomatin/prohibitin homologs K01423; COG: COG0330 Membrane protease subunits, stomatin/prohibitin homologs; Psort location: endoplasmic reticulum, score: 9 YP_001438843.1 COG: COG1585 Membrane protein implicated in regulation of membrane protease activity; Psort location: extracellular, including cell wall, score: 9 YP_001438844.1 COG: NOG07908 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001438845.1 COG: NOG22395 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001438846.1 KEGG: eci:UTI89_C3737 2.6e-14 yhdM; Zn(II)-responsive regulator of ZntA; COG: COG0789 Predicted transcriptional regulators; Psort location: nuclear, score: 23 YP_001438847.1 KEGG: ecj:JW0473 0. copA; copper transporter K01533; COG: COG2217 Cation transport ATPase; Psort location: endoplasmic reticulum, score: 9 YP_001438848.1 COG: COG3735 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001438849.1 KEGG: gme:Gmet_1354 0.0067 prolyl-tRNA synthetase K01881; COG: COG2606 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001438850.1 catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides YP_001438851.1 Psort location: nuclear, score: 23 YP_001438852.1 YbaL; member of the CPA-2 family of antiporters; uncharacterized protein YP_001438853.1 KEGG: ecc:c0597 4.5e-216 gsk; inosine-guanosine kinase K00892; COG: COG0524 Sugar kinases, ribokinase family; Psort location: cytoplasmic, score: 23 YP_001438854.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic YP_001438855.1 KEGG: yps:YPTB3821 9.1e-138 glxK; putative glycerate kinase K00865; COG: COG1929 Glycerate kinase; Psort location: cytoplasmic, score: 23 YP_001438856.1 KEGG: eci:UTI89_C3106 5.4e-21 ygbN; hypothetical permease YgbN K03299; COG: COG2610 H+/gluconate symporter and related permeases; Psort location: plasma membrane, score: 23 YP_001438857.1 KEGG: shn:Shewana3_2682 4.7e-63 transcriptional regulator, CdaR K01694; COG: COG3835 Sugar diacid utilization regulator; Psort location: cytoplasmic, score: 23 YP_001438858.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_001438859.1 molecular chaperone YP_001438860.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_001438861.1 COG: NOG23921 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001438862.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: cytoplasmic, score: 23 YP_001438863.1 KEGG: eci:UTI89_C4143 0.0035 putative autotransport adhesin K01423; COG: COG3188 P pilus assembly protein, porin PapC; Psort location: cytoplasmic, score: 23 YP_001438864.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: extracellular, including cell wall, score: 9 YP_001438865.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001438866.1 COG: COG0718 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001438867.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis YP_001438868.1 COG: COG2832 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001438869.1 COG: COG3923 Primosomal replication protein N; Psort location: mitochondrial, score: 23 YP_001438870.1 COG: NOG22666 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001438871.1 small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS YP_001438872.1 regulates the acrAB operon which is involved in susceptibility to dephalothin and cephaloridine YP_001438873.1 COG: COG0845 Membrane-fusion protein; Psort location: extracellular, including cell wall, score: 9 YP_001438874.1 KEGG: eci:UTI89_C2351 1.1e-107 yegO; hypothetical protein YegO K07789; COG: COG0841 Cation/multidrug efflux pump; Psort location: plasma membrane, score: 23 YP_001438875.1 COG: NOG09846 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001438876.1 with Hns involved in transcriptional regulation of hemolysin; non-specific DNA-binding protein which affects the production of multiple proteins YP_001438877.1 KEGG: sty:STY0515 7.7e-70 maA; maltose O-acetyltransferase K00661; COG: COG0110 Acetyltransferase (isoleucine patch superfamily); Psort location: mitochondrial, score: 23 YP_001438878.1 COG: NOG07873 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001438879.1 COG: COG0257 Ribosomal protein L36; Psort location: nuclear, score: 23 YP_001438880.1 COG: COG0254 Ribosomal protein L31; Psort location: nuclear, score: 23 YP_001438881.1 KEGG: vfi:VFA0360 3.1e-09 sensory transduction protein kinase; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 9 YP_001438882.1 KEGG: cal:orf19.541 1.8e-45 similar to bacterial enzymes of the iron/ascorbate oxidoreductase family K00475; COG: COG3491 Isopenicillin N synthase and related dioxygenases; Psort location: cytoplasmic, score: 23 YP_001438883.1 COG: COG1464 ABC-type metal ion transport system, periplasmic component/surface antigen; Psort location: extracellular, including cell wall, score: 9 YP_001438884.1 KEGG: rru:Rru_A0788 5.8e-72 ABC transporter component K06020; COG: COG1135 ABC-type metal ion transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001438885.1 KEGG: baa:BA_0884 7.0e-44 binding-protein-dependent transport systems inner membrane component K00294; COG: COG2011 ABC-type metal ion transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001438886.1 KEGG: mca:MCA1246 3.9e-32 methyltransferase CheR, putative K03412:K00575; COG: COG4943 Predicted signal transduction protein containing sensor and EAL domains; Psort location: endoplasmic reticulum, score: 9 YP_001438887.1 KEGG: sth:STH2923 5.8e-12 ribosomal-protein-alanine acetyltransferase K03789; COG: COG0456 Acetyltransferases; Psort location: cytoplasmic, score: 23 YP_001438888.1 KEGG: fal:FRAAL1741 0.00028 putative ABC transporter ATP-binding protein; COG: COG2364 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001438889.1 KEGG: rha:RHA1_ro05556 3.1e-105 transcriptional regulator/aminotransferase; COG: COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs; Psort location: mitochondrial, score: 23 YP_001438890.1 Psort location: endoplasmic reticulum, score: 9 YP_001438891.1 Psort location: cytoplasmic, score: 23 YP_001438892.1 Psort location: cytoplasmic, score: 23 YP_001438893.1 Psort location: nuclear, score: 23 YP_001438894.1 Psort location: mitochondrial, score: 23 YP_001438895.1 Psort location: extracellular, including cell wall, score: 9 YP_001438896.1 COG: NOG14044 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001438897.1 COG: COG1518 Uncharacterized protein predicted to be involved in DNA repair; Psort location: cytoplasmic, score: 23 YP_001438898.1 COG: NOG14131 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001438899.1 COG: NOG11452 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001438900.1 COG: NOG07898 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001438901.1 COG: NOG19581 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001438902.1 COG: NOG07915 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001438903.1 KEGG: afu:AF0071 4.4e-10 ATP-dependent RNA helicase, putative; COG: COG1203 Predicted helicases; Psort location: cytoplasmic, score: 23 YP_001438904.1 KEGG: eci:UTI89_C0482 8.1e-43 ybaZ; hypothetical protein YbaZ K07443; COG: COG3695 Predicted methylated DNA-protein cysteine methyltransferase; Psort location: cytoplasmic, score: 23 YP_001438905.1 COG: COG3126 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001438906.1 KEGG: ecs:ECs0506 1.0e-136 acyl-CoA THIoesterase II K01076; COG: COG1946 Acyl-CoA THIoesterase; Psort location: cytoplasmic, score: 23 YP_001438907.1 KEGG: ter:Tery_3993 1.0e-37 adenylate/guanylate cyclase K01769; COG: COG0004 Ammonia permease; Psort location: endoplasmic reticulum, score: 9 YP_001438908.1 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II 2 prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II 2 is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; functionally it is equivalent to protein P-II (GlnB), but itsexpression is driven by the presence of uridylyltransferase, nitrogen regulator I, and the absence of ammonia. YP_001438909.1 KEGG: cch:Cag_0453 1.0e-74 ATPase K06147; COG: COG1132 ABC-type multidrug transport system, ATPase and permease components; Psort location: endoplasmic reticulum, score: 9 YP_001438910.1 KEGG: reh:H16_A0776 2.9e-70 ABC-type transporter, ATPase and permease components: Prot2E family; COG: COG1132 ABC-type multidrug transport system, ATPase and permease components; Psort location: endoplasmic reticulum, score: 9 YP_001438911.1 Psort location: nuclear, score: 23 YP_001438912.1 COG: COG1522 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001438913.1 KEGG: sec:SC0500 2.2e-152 putative cysteine synthase/cystathionine beta-synthase K01738; COG: COG0031 Cysteine synthase; Psort location: cytoplasmic, score: 23 YP_001438914.1 Psort location: extracellular, including cell wall, score: 9 YP_001438915.1 KEGG: nma:NMA0905 3.0e-22 iga; IgA1 protease K01347; COG: KOG4809 Rab6 GTPase-interacting protein involved in endosome-to-TGN transport; Psort location: nuclear, score: 23 YP_001438916.1 KEGG: btl:BALH_4896 9.9e-22 hydrolase, haloacid dehalogenase-like family K01564; COG: COG0561 Predicted hydrolases of the HAD superfamily; Psort location: cytoplasmic, score: 23 YP_001438917.1 COG: COG4533 ABC-type uncharacterized transport system, periplasmic component; Psort location: mitochondrial, score: 23 YP_001438918.1 YbaX; catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0), as one of the early reactions of quenosine biosynthesis; quenosine is a modified nucleoside that occurs at the wobble position of GUN anticodons in tRNAs for Asn, Asp, Tyr, and His YP_001438919.1 KEGG: nph:NP3970A 1.7e-07 hydrolase (probable hydroxyacylglutathione hydrolase) 3 K01069; COG: COG0491 Zn-dependent hydrolases, including glyoxylases; Psort location: cytoplasmic, score: 23 YP_001438920.1 KEGG: gbe:GbCGDNIH1_1102 6.4e-11 short-chain acyl-CoA hydrolase; COG: COG0824 Predicted THIoesterase; Psort location: cytoplasmic, score: 23 YP_001438921.1 KEGG: bur:Bcep18194_A5099 7.1e-05 RNA binding S1; COG: COG1555 DNA uptake protein and related DNA-binding proteins; Psort location: extracellular, including cell wall, score: 9 YP_001438922.1 KEGG: sdy:SDY_0291 2.1e-232 ybaU; putative protease maturation protein K03770; COG: COG0760 Parvulin-like peptidyl-prolyl isomerase; Psort location: endoplasmic reticulum, score: 9 YP_001438923.1 histone-like DNA-binding protein YP_001438924.1 KEGG: spt:SPA2272 1.3e-266 lon; Lon protease K01338; COG: COG0466 ATP-dependent Lon protease, bacterial type; Psort location: cytoplasmic, score: 23 YP_001438925.1 binds and unfolds substrates as part of the ClpXP protease YP_001438926.1 KEGG: sty:STY0490 8.7e-94 clpP; ATP-dependent clp protease proteolytic subunit K01358; COG: COG0740 Protease subunit of ATP-dependent Clp proteases; Psort location: cytoplasmic, score: 23 YP_001438927.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_001438928.1 Psort location: mitochondrial, score: 23 YP_001438929.1 Psort location: nuclear, score: 23 YP_001438930.1 positive transcriptional regulator of morphogenetic pathway; controlling several genes involved in oxidative stress, acid stress, heat shock, osmotic shock, and carbon-starvation stress YP_001438931.1 COG: COG3056 Uncharacterized lipoprotein; Psort location: extracellular, including cell wall, score: 9 YP_001438932.1 in Escherichia coli this protein is a permease involved in peptidoglycan recycling; member of major facilitator superfamily; MFS; inner membrane protein YP_001438933.1 COG: NOG21760 non supervised orthologous group; Psort location: plasma membrane, score: 23 YP_001438934.1 KEGG: mbo:Mb0358 4.1e-87 dnaK; probable chaperone protein DnaK (heat shock protein 70) (heat shock 70 kda protein) (HSP70) K04043; COG: COG0443 Molecular chaperone; Psort location: cytoplasmic, score: 23 YP_001438935.1 KEGG: eci:UTI89_C0456 2.6e-149 cyoA; cytochrome o ubiquinol oxidase subunit II K02297; COG: COG1622 Heme/copper-type cytochrome/quinol oxidases, subunit 2; Psort location: endoplasmic reticulum, score: 9 YP_001438936.1 KEGG: eco:b0431 0. cyoB; cytochrome o ubiquinol oxidase subunit I K02298; COG: COG0843 Heme/copper-type cytochrome/quinol oxidases, subunit 1; Psort location: plasma membrane, score: 23 YP_001438937.1 KEGG: sty:STY0483 9.9e-93 cyoC; cytochrome o ubiquinol oxidase subunit III K02299; COG: COG1845 Heme/copper-type cytochrome/quinol oxidase, subunit 3; Psort location: endoplasmic reticulum, score: 9 YP_001438938.1 KEGG: eci:UTI89_C0452 1.2e-41 cyoD; cytochrome o ubiquinol oxidase protein CyoD K02300; COG: COG3125 Heme/copper-type cytochrome/quinol oxidase, subunit 4; Psort location: endoplasmic reticulum, score: 9 YP_001438939.1 converts protoheme IX and farnesyl diphosphate to heme O YP_001438940.1 KEGG: shn:Shewana3_1692 1.1e-07 Xaa-His dipeptidase K01270; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001438941.1 COG: COG1666 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001438942.1 KEGG: sty:STY0473 4.3e-115 apbA; 2-dehydropantoate 2-reductase K00077; COG: COG1893 Ketopantoate reductase; Psort location: cytoplasmic, score: 23 YP_001438943.1 KEGG: eci:UTI89_C0447 2.9e-86 THIJ; 4-methyl-5(B-hydroxyethyl)-THIazole monophosphate biosynthesis enzyme K03152; COG: COG0693 Putative intracellular protease/amidase; Psort location: cytoplasmic, score: 23 YP_001438944.1 Required for the synthesis of the thiazole moiety YP_001438945.1 catalyzes the bidirectional exonucleolytic cleavage of DNA YP_001438946.1 KEGG: sty:STY0462 1.0e-122 ispA; geranyltranstransferase K00795; COG: COG0142 Geranylgeranyl pyrophosphate synthase; Psort location: cytoplasmic, score: 23 YP_001438947.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_001438948.1 KEGG: eco:b0419 2.9e-148 yajO; predicted oxidoreductase, NAD(P)-binding; COG: COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001438949.1 KEGG: sty:STY0459 1.8e-70 phosphatidylglycerophosphatase A K01095; COG: COG1267 Phosphatidylglycerophosphatase A and related proteins; Psort location: endoplasmic reticulum, score: 9 YP_001438950.1 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP YP_001438951.1 Regulates rRNA biosynthesis by transcriptional antitermination YP_001438952.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_001438953.1 riboflavin biosynthesis protein which catalyzes the deamination and reduction steps in the riboflavin biosynthesis pathway; catalyzes the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 5-amino-6-(5-phosphoribitylamino)uracil YP_001438954.1 KEGG: eci:UTI89_C0435 3.6e-72 ybaD; hypothetical protein K07738; COG: COG1327 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains; Psort location: cytoplasmic, score: 23 YP_001438955.1 COG: NOG07872 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001438956.1 COG: COG3248 Nucleoside-binding outer membrane protein; Psort location: extracellular, including cell wall, score: 9 YP_001438957.1 Psort location: nuclear, score: 23 YP_001438958.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF YP_001438959.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane YP_001438960.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex YP_001438961.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) YP_001438962.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step YP_001438963.1 Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP YP_001438964.1 COG: NOG14010 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001438965.1 KEGG: sma:SAV6022 1.8e-05 sucB; putative dihydrolipoamide S-succinyltransferase K00658; COG: COG5373 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001438966.1 KEGG: eci:UTI89_C0425 2.7e-234 malZ; maltodextrin glucosidase K01187; COG: COG0366 Glycosidases; Psort location: extracellular, including cell wall, score: 9 YP_001438967.1 cryptic permease that may be involved in the transport of proline across the inner membrane; in Salmonella typhimurium, the proY gene is silent unless overexpressed on a multicopy plasmid or activated by a proZ mutation YP_001438968.1 KEGG: rpb:RPB_2641 0.00046 V-type H(+)-translocating pyrophosphatase K01507; COG: COG1114 Branched-chain amino acid permeases; Psort location: plasma membrane, score: 23 YP_001438969.1 membrane-associated histidine protein kinase that phosphorylates phoB in response to environmental signals as part of the two-component phosphate regulatory system phoR/phoB YP_001438970.1 two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB YP_001438971.1 with SbcC cleaves DNA hairpin structure, also has 5' single-strand endonuclease activity YP_001438972.1 with SbcD cleaves DNA hairpin structures; also has 5' single-strand endonuclease activity YP_001438973.1 KEGG: rru:Rru_A2630 1.2e-85 ROK K00885; COG: COG1940 Transcriptional regulator/sugar kinase; Psort location: cytoplasmic, score: 23 YP_001438974.1 Required for efficient pilin antigenic variation YP_001438975.1 COG: COG3123 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001438976.1 COG: NOG06193 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001438977.1 Psort location: cytoplasmic, score: 23 YP_001438978.1 COG: NOG13867 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001438979.1 KEGG: sec:SC0429 5.9e-56 aroL; shikimate kinase II K00891; COG: COG0703 Shikimate kinase; Psort location: cytoplasmic, score: 23 YP_001438980.1 COG: COG3416 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001438981.1 COG: COG1671 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001438982.1 COG: COG2323 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001438983.1 COG: NOG18327 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001438984.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate YP_001438985.1 KEGG: cal:orf19.3526 2.2e-56 ITR2; myo-inositol transporter K08140; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001438986.1 Psort location: cytoplasmic, score: 23 YP_001438987.1 Psort location: cytoplasmic, score: 23 YP_001438988.1 COG: NOG14126 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001438989.1 KEGG: ace:Acel_1971 2.3e-08 dTMP kinase K00943; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001438990.1 COG: COG3921 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001438991.1 KEGG: ecs:ECs0431 8.4e-151 D-alanine-D-alanine ligase K01921; COG: COG1181 D-alanine-D-alanine ligase and related ATP-grasp enzymes; Psort location: cytoskeletal, score: 9 YP_001438992.1 COG: NOG09786 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001438993.1 COG: NOG11448 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001438994.1 COG: NOG06003 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001438995.1 in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope YP_001438996.1 KEGG: bma:BMAA0508 1.4e-24 isochorismatase family protein K05993; COG: COG1335 Amidases related to nicotinamidase; Psort location: cytoplasmic, score: 23 YP_001438997.1 this protein has no known enzymatic function YP_001438998.1 COG: NOG06782 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001438999.1 KEGG: eci:UTI89_C0334 2.3e-52 hypothetical protein; COG: COG3468 Type V secretory pathway, adhesin AidA; Psort location: extracellular, including cell wall, score: 9 YP_001439000.1 COG: COG1546 Uncharacterized protein (competence- and mitomycin-induced); Psort location: cytoplasmic, score: 23 YP_001439001.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_001439002.1 KEGG: oih:OB0869 7.9e-06 1-acyl-sn-glycerol-3-phosphate acetyltransferase K00655; COG: COG3176 Putative hemolysin; Psort location: endoplasmic reticulum, score: 9 YP_001439003.1 COG: NOG18699 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001439004.1 catalyzes the conversion of taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde concurrently with the conversion of alpha-ketoglutarate to succinate and carbon dioxide; non-heme iron oxidase; allows the use of taurine as an alternative sulfur source; forms homodimers YP_001439005.1 KEGG: rha:RHA1_ro08170 3.8e-20 ABC transporter, permease component; COG: COG0600 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001439006.1 Part of the ABC transporter complex tauABC involved in taurine import YP_001439007.1 COG: COG4521 ABC-type taurine transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001439008.1 converts homocysteine and S-adenosyl-methionine to methionine and S-adenosyl-homocysteine or S-methyl-methionine and homocysteine to two methionines YP_001439009.1 KEGG: eci:UTI89_C0120 1.5e-75 aroP; aromatic amino acid transport protein AroP K03293; COG: COG0833 Amino acid transporters; Psort location: plasma membrane, score: 23 YP_001439010.1 KEGG: xcb:XC_1452 0. formate dehydrogenase related protein K00123; COG: COG3383 Uncharacterized anaerobic dehydrogenase; Psort location: cytoplasmic, score: 23 YP_001439011.1 COG: NOG39140 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001439012.1 KEGG: xcc:XCC2662 1.4e-157 qxtA; cytochrome D oxidase subunit A K00425; COG: COG1271 Cytochrome bd-type quinol oxidase, subunit 1; Psort location: plasma membrane, score: 23 YP_001439013.1 KEGG: xcc:XCC2661 1.7e-74 qxtB; cytochrome D oxidase subunit B K00426; COG: COG1294 Cytochrome bd-type quinol oxidase, subunit 2; Psort location: endoplasmic reticulum, score: 9 YP_001439014.1 Psort location: endoplasmic reticulum, score: 9 YP_001439015.1 KEGG: reh:H16_A2322 6.2e-36 ATPase K01529; COG: COG1485 Predicted ATPase; Psort location: cytoplasmic, score: 23 YP_001439016.1 KEGG: ecp:ECP_2404 6.6e-119 putative acyltransferase K00680; COG: COG1560 Lauroyl/myristoyl acyltransferase; Psort location: mitochondrial, score: 23 YP_001439017.1 Psort location: endoplasmic reticulum, score: 9 YP_001439018.1 COG: COG1349 Transcriptional regulators of sugar metabolism; Psort location: cytoplasmic, score: 23 YP_001439019.1 KEGG: bur:Bcep18194_A4044 3.0e-68 nucleoside diphosphate pyrophosphatase K01515; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: cytoplasmic, score: 23 YP_001439020.1 KEGG: pfl:PFL_3331 7.7e-22 nudF; ADP-ribose pyrophosphatase K01515; COG: NOG33362 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001439021.1 COG: COG3434 Predicted signal transduction protein containing EAL and modified HD-GYP domains; Psort location: cytoplasmic, score: 23 YP_001439022.1 Psort location: endoplasmic reticulum, score: 9 YP_001439023.1 Psort location: mitochondrial, score: 23 YP_001439024.1 KEGG: eca:ECA3327 2.2e-40 putative carbonic anhydrase K01673; COG: COG0288 Carbonic anhydrase; Psort location: cytoplasmic, score: 23 YP_001439025.1 KEGG: bpm:BURPS1710b_1425 3.0e-107 sul1; sulfate transporter family protein K01672; COG: COG0659 Sulfate permease and related transporters (MFS superfamily); Psort location: plasma membrane, score: 23 YP_001439026.1 KEGG: tbd:Tbd_2668 1.1e-06 phosphoribosylaminoimidazole-succinocarboxamide (SAICAR) synthetase K01923; COG: COG0628 Predicted permease; Psort location: plasma membrane, score: 23 YP_001439027.1 KEGG: atc:AGR_L_2936 0. probable quinate dehydrogenase K00117; COG: COG4993 Glucose dehydrogenase; Psort location: endoplasmic reticulum, score: 9 YP_001439028.1 KEGG: shn:Shewana3_3435 1.4e-08 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001439029.1 COG: NOG23817 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001439030.1 COG: COG3238 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001439031.1 KEGG: shn:Shewana3_3435 0.00086 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001439032.1 KEGG: eca:ECA0069 4.3e-76 padC, pad; phenolic acid decarboxylase K01618; COG: COG3479 Phenolic acid decarboxylase; Psort location: cytoplasmic, score: 23 YP_001439033.1 KEGG: pto:PTO0598 3.3e-62 glucoamylase K01178; COG: COG3387 Glucoamylase and related glycosyl hydrolases; Psort location: cytoplasmic, score: 23 YP_001439034.1 Psort location: nuclear, score: 23 YP_001439035.1 COG: COG1464 ABC-type metal ion transport system, periplasmic component/surface antigen; Psort location: extracellular, including cell wall, score: 9 YP_001439036.1 KEGG: baa:BA_0884 1.3e-37 binding-protein-dependent transport systems inner membrane component K00294; COG: COG2011 ABC-type metal ion transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001439037.1 KEGG: rru:Rru_A0788 4.4e-83 ABC transporter component K06020; COG: COG1135 ABC-type metal ion transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001439038.1 KEGG: reh:H16_A0369 5.6e-99 rfbB1; dTDP-D-glucose 4,6-dehydratase K01710; COG: COG3211 Predicted phosphatase; Psort location: cytoplasmic, score: 23 YP_001439039.1 Psort location: endoplasmic reticulum, score: 9 YP_001439040.1 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate YP_001439041.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001439042.1 forms a homotetramer; hydrolyzes lactose disaccharide to galactose and glucose; converts lactose to allolactose which is the natural inducer of the lac operon YP_001439043.1 transcriptional repressor of lac operon; forms a homotetramer as a dimer of dimers; binds specific sites in lac operon resulting in DNA looping between the operators; binds allolactose as inducer YP_001439044.1 KEGG: reh:H16_B2351 1.0e-35 short-chain dehydrogenase of various substrate specificities; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001439045.1 COG: NOG18146 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001439046.1 COG: COG1309 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001439047.1 KEGG: ape:APE_1501.1 1.9e-09 ribonuclease UK114; COG: COG0251 Putative translation initiation inhibitor, yjgF family; Psort location: cytoplasmic, score: 23 YP_001439048.1 KEGG: sth:STH1645 1.7e-111 glyceraldehyde-3-phosphate dehydrogenase K00134; COG: COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Psort location: cytoplasmic, score: 23 YP_001439049.1 KEGG: bpm:BURPS1710b_A2214 9.1e-35 ftrA; transcriptional activator FtrA K00356; COG: COG4977 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain; Psort location: endoplasmic reticulum, score: 9 YP_001439050.1 Psort location: endoplasmic reticulum, score: 9 YP_001439051.1 Psort location: nuclear, score: 23 YP_001439052.1 Psort location: nuclear, score: 23 YP_001439053.1 Psort location: endoplasmic reticulum, score: 9 YP_001439054.1 COG: NOG27561 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001439055.1 COG: NOG26268 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001439056.1 Psort location: nuclear, score: 23 YP_001439057.1 KEGG: mlo:mll3679 4.6e-88 membrane dipeptidase K01273; COG: COG2355 Zn-dependent dipeptidase, microsomal dipeptidase homolog; Psort location: cytoplasmic, score: 23 YP_001439058.1 possibly involved in transport of pyrroloquinoline quinone transport YP_001439059.1 Required in the synthesis of PPQ, but its exact function is unknown YP_001439060.1 COG: NOG16986 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001439061.1 KEGG: dar:Daro_2097 6.6e-07 radical SAM K04069; COG: COG0535 Predicted Fe-S oxidoreductases; Psort location: cytoplasmic, score: 23 YP_001439062.1 KEGG: pae:PA1973 3.5e-74 pqqF; pyrroloquinoline quinone biosynthesis protein F; COG: COG1025 Secreted/periplasmic Zn-dependent peptidases, insulinase-like; Psort location: mitochondrial, score: 23 YP_001439063.1 KEGG: shn:Shewana3_2650 2.1e-125 acetate kinase K00925; COG: COG0747 ABC-type dipeptide transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001439064.1 catalyzes the release of the N-terminal amino acid from a tripeptide YP_001439065.1 Psort location: cytoplasmic, score: 23 YP_001439066.1 Psort location: mitochondrial, score: 23 YP_001439067.1 Psort location: nuclear, score: 23 YP_001439068.1 Psort location: cytoplasmic, score: 23 YP_001439069.1 Psort location: cytoplasmic, score: 23 YP_001439070.1 COG: NOG35673 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001439071.1 COG: COG3755 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001439072.1 Psort location: endoplasmic reticulum, score: 9 YP_001439073.1 Psort location: mitochondrial, score: 23 YP_001439074.1 Psort location: extracellular, including cell wall, score: 9 YP_001439075.1 COG: NOG27449 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001439076.1 Psort location: cytoplasmic, score: 23 YP_001439077.1 Psort location: cytoplasmic, score: 23 YP_001439078.1 Psort location: cytoplasmic, score: 23 YP_001439079.1 KEGG: lpl:lp_1289 0.00020 adenine phosphoribosyltransferase; Psort location: nuclear, score: 23 YP_001439080.1 COG: COG0758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake; Psort location: cytoplasmic, score: 23 YP_001439081.1 Psort location: cytoplasmic, score: 23 YP_001439082.1 COG: NOG22117 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001439083.1 KEGG: sty:STY4832 2.1e-22 Bacteriophage P4 DNA primase; COG: COG5519 Superfamily II helicase and inactivated derivatives; Psort location: endoplasmic reticulum, score: 9 YP_001439084.1 Psort location: cytoplasmic, score: 23 YP_001439085.1 Psort location: extracellular, including cell wall, score: 9 YP_001439086.1 Psort location: nuclear, score: 23 YP_001439087.1 COG: NOG06079 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001439088.1 Psort location: nuclear, score: 23 YP_001439089.1 Psort location: mitochondrial, score: 23 YP_001439090.1 COG: COG0582 Integrase; Psort location: cytoplasmic, score: 23 YP_001439091.1 COG: COG2246 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001439092.1 KEGG: eco:b2351 1.1e-146 yfdH; CPS-53 (KpLE1) prophage; putative bactoprenol glucosyl transferase K00754; COG: COG0463 Glycosyltransferases involved in cell wall biogenesis; Psort location: vacuolar, score: 9 YP_001439093.1 COG: NOG37959 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001439094.1 COG: COG3210 Large exoproteins involved in heme utilization or adhesion; Psort location: cytoplasmic, score: 23 YP_001439095.1 COG: NOG11915 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001439096.1 Psort location: cytoplasmic, score: 23 YP_001439097.1 Psort location: cytoplasmic, score: 23 YP_001439098.1 Psort location: cytoplasmic, score: 23 YP_001439099.1 KEGG: azo:azo0200 6.0e-08 sbcC; exonuclease SbcC, putative K01146; COG: COG5281 Phage-related minor tail protein; Psort location: cytoplasmic, score: 23 YP_001439100.1 Psort location: endoplasmic reticulum, score: 9 YP_001439101.1 Psort location: cytoplasmic, score: 23 YP_001439102.1 Psort location: cytoplasmic, score: 23 YP_001439103.1 Psort location: cytoplasmic, score: 23 YP_001439104.1 Psort location: extracellular, including cell wall, score: 9 YP_001439105.1 Psort location: nuclear, score: 23 YP_001439106.1 Psort location: cytoplasmic, score: 23 YP_001439107.1 Psort location: cytoplasmic, score: 23 YP_001439108.1 Psort location: cytoplasmic, score: 23 YP_001439109.1 Psort location: cytoplasmic, score: 23 YP_001439110.1 Psort location: cytoplasmic, score: 23 YP_001439111.1 Psort location: cytoplasmic, score: 23 YP_001439112.1 Psort location: cytoplasmic, score: 23 YP_001439113.1 KEGG: eci:UTI89_C0735 0.00078 tolA; membrane spanning protein TolA K03646; Psort location: cytoplasmic, score: 23 YP_001439114.1 Psort location: extracellular, including cell wall, score: 9 YP_001439115.1 COG: COG2369 Uncharacterized protein, homolog of phage Mu protein gp30; Psort location: cytoplasmic, score: 23 YP_001439116.1 Psort location: cytoplasmic, score: 23 YP_001439117.1 COG: COG5410 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001439118.1 COG: COG3728 Phage terminase, small subunit; Psort location: cytoplasmic, score: 23 YP_001439119.1 Psort location: cytoplasmic, score: 23 YP_001439120.1 Psort location: cytoplasmic, score: 23 YP_001439121.1 Psort location: cytoplasmic, score: 23 YP_001439122.1 Psort location: cytoplasmic, score: 23 YP_001439123.1 COG: COG3645 Uncharacterized phage-encoded protein; Psort location: cytoplasmic, score: 23 YP_001439124.1 Psort location: nuclear, score: 23 YP_001439125.1 Psort location: endoplasmic reticulum, score: 9 YP_001439126.1 Psort location: extracellular, including cell wall, score: 9 YP_001439127.1 KEGG: ecc:c1562 3.0e-43 ybcS; probable lysozyme from lambdoid prophage DLP12 K01185; COG: COG3772 Phage-related lysozyme (muraminidase); Psort location: endoplasmic reticulum, score: 9 YP_001439128.1 COG: NOG38344 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001439129.1 Psort location: cytoplasmic, score: 23 YP_001439130.1 Psort location: cytoplasmic, score: 23 YP_001439131.1 Psort location: cytoplasmic, score: 23 YP_001439132.1 Psort location: cytoplasmic, score: 23 YP_001439133.1 Psort location: nuclear, score: 23 YP_001439134.1 KEGG: sto:ST1438 0.0086 V-type H+-transporting ATPase subunit D K02120; Psort location: cytoplasmic, score: 23 YP_001439135.1 COG: NOG14016 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001439136.1 Psort location: nuclear, score: 23 YP_001439137.1 Psort location: nuclear, score: 23 YP_001439138.1 COG: NOG23760 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001439139.1 Psort location: cytoplasmic, score: 23 YP_001439140.1 COG: NOG18339 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001439141.1 COG: NOG22509 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001439142.1 Psort location: cytoplasmic, score: 23 YP_001439143.1 Psort location: cytoplasmic, score: 23 YP_001439144.1 Psort location: nuclear, score: 23 YP_001439145.1 Psort location: cytoplasmic, score: 23 YP_001439146.1 Psort location: cytoplasmic, score: 23 YP_001439147.1 Psort location: nuclear, score: 23 YP_001439148.1 KEGG: ecs:ECs1190 2.6e-133 replication protein P K02314; COG: COG0305 Replicative DNA helicase; Psort location: cytoplasmic, score: 23 YP_001439149.1 COG: NOG24180 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001439150.1 Psort location: cytoplasmic, score: 23 YP_001439151.1 KEGG: tcx:Tcr_1234 2.8e-07 putative prophage repressor K01356; COG: COG1974 SOS-response transcriptional repressors (RecA-mediated autopeptidases); Psort location: cytoplasmic, score: 23 YP_001439152.1 Psort location: nuclear, score: 23 YP_001439153.1 Psort location: nuclear, score: 23 YP_001439154.1 Psort location: cytoplasmic, score: 23 YP_001439155.1 Psort location: cytoplasmic, score: 23 YP_001439156.1 Psort location: endoplasmic reticulum, score: 9 YP_001439157.1 Psort location: cytoplasmic, score: 23 YP_001439158.1 Psort location: cytoplasmic, score: 23 YP_001439159.1 Psort location: cytoplasmic, score: 23 YP_001439160.1 Psort location: nuclear, score: 23 YP_001439161.1 Psort location: nuclear, score: 23 YP_001439162.1 Psort location: nuclear, score: 23 YP_001439163.1 Psort location: nuclear, score: 23 YP_001439164.1 Psort location: nuclear, score: 23 YP_001439165.1 Psort location: cytoplasmic, score: 23 YP_001439166.1 Psort location: nuclear, score: 23 YP_001439167.1 Psort location: cytoplasmic, score: 23 YP_001439168.1 Psort location: cytoplasmic, score: 23 YP_001439169.1 Psort location: cytoplasmic, score: 23 YP_001439170.1 Psort location: cytoplasmic, score: 23 YP_001439171.1 Psort location: cytoplasmic, score: 23 YP_001439172.1 COG: COG0582 Integrase; Psort location: cytoplasmic, score: 23 YP_001439173.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway YP_001439174.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis YP_001439175.1 Psort location: cytoplasmic, score: 23 YP_001439176.1 COG: COG3203 Outer membrane protein (porin); Psort location: extracellular, including cell wall, score: 9 YP_001439177.1 involved in the expression of csgBA which is involved in curli formation; interacts with sigmaS YP_001439178.1 forms a 1:1 complex with the unphosphorylated from of enzyme IIAGlc; FrsA may promote fermentation YP_001439179.1 catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively YP_001439180.1 KEGG: stm:STM0316 2.0e-213 pepD; aminoacyl-histidine dipeptidase K01270; COG: COG2195 Di- and tripeptidases; Psort location: cytoplasmic, score: 23 YP_001439181.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function YP_001439182.1 COG: COG3034 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001439183.1 KEGG: reh:H16_A0476 5.6e-67 predicted glutamine amidotransferase class II; COG: COG0121 Predicted glutamine amidotransferase; Psort location: cytoplasmic, score: 23 YP_001439184.1 catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate YP_001439185.1 functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA YP_001439186.1 KEGG: eco:b0219 1.4e-109 yafV; predicted C-N hydrolase family amidase, NAD(P)-binding; COG: COG0388 Predicted amidohydrolase; Psort location: cytoplasmic, score: 23 YP_001439187.1 3'-5' exonuclease of DNA polymerase III YP_001439188.1 KEGG: ecp:ECP_0220 1.1e-75 ribonuclease HI K03469; COG: COG0328 Ribonuclease HI; Psort location: cytoplasmic, score: 23 YP_001439189.1 KEGG: vfi:VF1937 2.8e-40 methyltransferase K00599; COG: COG0500 SAM-dependent methyltransferases; Psort location: cytoplasmic, score: 23 YP_001439190.1 catalyzes the hydrolysis of S-D-lactoylglutathione to D-lactic acid and reduced glutathione; plays an important role in cellular detoxification using glutathione YP_001439191.1 catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; may play a role in recycling muropeptides during cell division and/or cell elongation; in Helicobacter pylori MltD is a endolytic transglycosylase involved mainly in the rearrangement of the peptidoglycan layer of the bacterial cell wall YP_001439192.1 KEGG: eci:UTI89_C0229 1.2e-96 yafE; conserved hypothetical protein YafE K00599; COG: COG0500 SAM-dependent methyltransferases; Psort location: cytoplasmic, score: 23 YP_001439193.1 COG: COG3021 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001439194.1 KEGG: shn:Shewana3_3435 1.8e-11 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001439195.1 KEGG: sec:SC0251 1.7e-111 yafB; 2,5-diketo-D-gluconate reductase B K06222; COG: COG0656 Aldo/keto reductases, related to diketogulonate reductase; Psort location: cytoplasmic, score: 23 YP_001439197.1 Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate YP_001439198.1 part of the metNIQ transport system for methionine YP_001439199.1 part of the MetNIQ methionine uptake system YP_001439200.1 COG: COG1464 ABC-type metal ion transport system, periplasmic component/surface antigen; Psort location: extracellular, including cell wall, score: 9 YP_001439201.1 COG: NOG09836 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001439202.1 KEGG: eci:UTI89_C0211 3.3e-101 yaeB; hypothetical protein YaeB; COG: COG1720 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001439203.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_001439204.1 COG: COG3015 Uncharacterized lipoprotein NlpE involved in copper resistance; Psort location: endoplasmic reticulum, score: 9 YP_001439205.1 KEGG: reh:H16_A3611 7.6e-31 pth2; peptidyl-tRNA hydrolase; COG: COG1186 Protein chain release factor B; Psort location: nuclear, score: 23 YP_001439206.1 KEGG: bpm:BURPS1710b_0319 2.3e-38 YaeQ protein K00356; COG: COG4681 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001439207.1 COG: NOG13866 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001439208.1 Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination YP_001439209.1 KEGG: cvi:CV4386 1.8e-15 cyc; cytochrome-c oxidase K00403; COG: COG2863 Cytochrome c553; Psort location: extracellular, including cell wall, score: 9 YP_001439210.1 KEGG: stm:STM0236 3.5e-136 mesJ; cell cycle protein K04075; COG: COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control; Psort location: cytoplasmic, score: 23 YP_001439211.1 KEGG: ecc:c0225 3.9e-59 yaeR; hypothetical protein YaeR K01759; COG: COG0346 Lactoylglutathione lyase and related lyases; Psort location: cytoplasmic, score: 23 YP_001439212.1 KEGG: stt:t0236 0. ldcC; lysine decarboxylase K01582; COG: COG1982 Arginine/lysine/orniTHIne decarboxylases; Psort location: cytoplasmic, score: 23 YP_001439213.1 KEGG: bam:Bamb_1428 1.1e-27 chitinase K01183; COG: COG3979 Uncharacterized protein contain chitin-binding domain type 3; Psort location: extracellular, including cell wall, score: 9 YP_001439214.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein YP_001439215.1 Psort location: cytoplasmic, score: 23 YP_001439216.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase YP_001439217.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_001439218.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM YP_001439219.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis YP_001439220.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP YP_001439221.1 Psort location: mitochondrial, score: 23 YP_001439222.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis YP_001439223.1 COG: COG2825 Outer membrane protein; Psort location: cytoplasmic, score: 23 YP_001439224.1 part of a complex with YfgL, YfiO, and NlpB involved in outer membrane protein biosynthesis; involved in the assembly of outer membrane proteins YP_001439225.1 catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response YP_001439226.1 catalyzes the synthesis of CDP-diglyceride from CTP and phosphatidate YP_001439227.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate YP_001439228.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate YP_001439229.1 KEGG: fth:FTH_0222 3.8e-45 prfH; protein-synthesizing GTPase; COG: COG0233 Ribosome recycling factor; Psort location: nuclear, score: 23 YP_001439230.1 Catalyzes the phosphorylation of UMP to UDP YP_001439231.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_001439232.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_001439233.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn YP_001439234.1 catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein YP_001439235.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway YP_001439236.1 COG: NOG09673 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001439237.1 protease Do; required at high temperature; degrades damaged proteins YP_001439238.1 forms a homotetramer; requires magnesium for activity; catalyzes the hydrolysis of dGTP to form deoxyguanosine and triphosphate YP_001439239.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine YP_001439240.1 solute binding component of the vitamin B12 transport system BtuCDF YP_001439241.1 COG: COG2860 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001439242.1 COG: COG0316 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001439243.1 Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation YP_001439244.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway YP_001439245.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome YP_001439246.1 Part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; binds to all hydroxamate siderophores YP_001439247.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter YP_001439248.1 involved with the transport of ferrichrome across the outer membrane; binds the ferrichrome-iron ligand and interacts with the TonB protein YP_001439249.1 bifunctional periplasmic enzyme; contains transglycosylase and transpeptidase activity; major enzyme for peptidoglycan biosynthesis in Escherichia coli; transmembrane protein; forms dimers; three variants, one of which may be a degradation product, while the other appears to result from an alternative initiation site, are found within the cell YP_001439250.1 similar in sequence to the ATP-dependent RNA helicase HrpA YP_001439251.1 KEGG: stm:STM0188 2.1e-67 ligT; 2'-5' RNA ligase K01975; COG: COG1514 2-5 RNA ligase; Psort location: extracellular, including cell wall, score: 9 YP_001439252.1 Regulatory factor involved in maltose metabolism YP_001439253.1 COG: COG1734 DnaK suppressor protein; Psort location: nuclear, score: 23 YP_001439254.1 this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu YP_001439255.1 Psort location: cytoplasmic, score: 23 YP_001439256.1 KEGG: eco:b0143 3.4e-67 pcnB; poly(A) polymerase I K00970; COG: COG0617 tRNA nucleotidyltransferase/poly(A) polymerase; Psort location: nuclear, score: 23 YP_001439257.1 KEGG: spt:SPA0189 9.2e-58 folK; 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase K00950; COG: COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; Psort location: extracellular, including cell wall, score: 9 YP_001439258.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate YP_001439259.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine YP_001439260.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5) YP_001439261.1 KEGG: azo:azo2324 9.7e-22 putative polysaccharide deacetylase; COG: COG0726 Predicted xylanase/chitin deacetylase; Psort location: extracellular, including cell wall, score: 9 YP_001439262.1 COG: COG0842 ABC-type multidrug transport system, permease component; Psort location: plasma membrane, score: 23 YP_001439263.1 KEGG: pen:PSEEN1596 6.9e-101 ABC transporter, ATP-binding protein; COG: COG1131 ABC-type multidrug transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001439264.1 catalyzes the interconversion of bicarbonate and carbon dioxide YP_001439265.1 KEGG: sec:SC0170 1.5e-82 hpt; hypoxanTHIne phosphoribosyltransferase K00760; COG: COG0634 HypoxanTHIne-guanine phosphoribosyltransferase; Psort location: cytoplasmic, score: 23 YP_001439266.1 KEGG: stm:STM0169 0. gcd; glucose dehydrogenase K00117; COG: COG4993 Glucose dehydrogenase; Psort location: endoplasmic reticulum, score: 9 YP_001439267.1 laccase; copper-stimulated phenoloxidase and ferroxidase which may be involved in copper detoxification YP_001439268.1 Psort location: cytoplasmic, score: 23 YP_001439269.1 COG: NOG09835 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001439270.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine YP_001439271.1 S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine YP_001439272.1 COG: COG3112 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001439273.1 Psort location: extracellular, including cell wall, score: 9 YP_001439274.1 catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate YP_001439275.1 KEGG: aha:AHA_2211 8.8e-05 dnaX; DNA polymerase III, subunits gamma and tau K00961; COG: NOG06276 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001439276.1 COG: NOG09806 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001439277.1 COG: NOG11181 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001439278.1 E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_001439279.1 Psort location: cytoplasmic, score: 23 YP_001439280.1 E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains YP_001439281.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC YP_001439282.1 activates lctPRD operon; autoregulates itself through repression of pdhR-aceEF-lpdA operon; regulates pyruvate dehydrogenase complex YP_001439283.1 KEGG: eci:UTI89_C0120 8.5e-222 aroP; aromatic amino acid transport protein AroP K03293; COG: COG1113 Gamma-aminobutyrate permease and related permeases; Psort location: plasma membrane, score: 23 YP_001439284.1 KEGG: eci:UTI89_C4210 1.9e-112 yicJ; hypothetical symporter YicJ K03292; COG: COG2211 Na+/melibiose symporter and related transporters; Psort location: plasma membrane, score: 23 YP_001439285.1 KEGG: sde:Sde_0777 4.0e-105 ribosomal protein L11 methyltransferase K01209; COG: COG3940 Predicted beta-xylosidase; Psort location: cytoplasmic, score: 23 YP_001439286.1 involved in regulation of beta-lactamase; putative signaling protein YP_001439287.1 KEGG: eci:UTI89_C0118 1.9e-80 ampD; AmpD protein K03806; COG: COG3023 Negative regulator of beta-lactamase expression; Psort location: cytoplasmic, score: 23 YP_001439288.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide YP_001439289.1 COG: COG4969 Tfp pilus assembly protein, major pilin PilA; Psort location: mitochondrial, score: 23 YP_001439290.1 KEGG: pen:PSEEN2333 5.6e-83 xcpR-2; type II secretion pathway protein E K01509; COG: COG2804 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB; Psort location: cytoplasmic, score: 23 YP_001439291.1 COG: COG1459 Type II secretory pathway, component PulF; Psort location: endoplasmic reticulum, score: 9 YP_001439292.1 catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate YP_001439293.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis YP_001439294.1 Psort location: cytoplasmic, score: 23 YP_001439295.1 COG: COG4582 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001439296.1 KEGG: gbe:GbCGDNIH1_1027 1.3e-05 ribonuclease G; COG: COG3024 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001439297.1 KEGG: spt:SPA0139 1.8e-52 mutT; 7,8-dihydro-8-oxoguanine-triphosphatase K03574; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: cytoplasmic, score: 23 YP_001439298.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_001439299.1 secM translational pause allows for the initiation of secA translation YP_001439300.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis YP_001439301.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_001439302.1 ATP-binding involved in recruitment of FtsK to Z ring; essential cell division protein; colocalizes with FtsZ through direct interaction to the septal ring structure; structurally similar to eukaryotic actin; binds directly to the cell membrane YP_001439303.1 involved in septum formation YP_001439304.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_001439305.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_001439306.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_001439307.1 integral membrane protein involved in stabilizing FstZ ring during cell division YP_001439308.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation YP_001439309.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_001439310.1 KEGG: sbo:SBO_0074 6.7e-206 murF; D-alanine:D-alanine-adding enzyme K01929; COG: COG0770 UDP-N-acetylmuramyl pentapeptide synthase; Psort location: cytoplasmic, score: 23 YP_001439311.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate YP_001439312.1 KEGG: eco:b0084 3.0e-297 ftsI, pbpB, sep; division-specific transpeptidase, penicillin-binding protein 3 K03587; COG: COG0768 Cell division protein FtsI/penicillin-binding protein 2; Psort location: golgi, score: 9 YP_001439313.1 membrane bound cell division protein at septum containing leucine zipper motif YP_001439314.1 KEGG: spt:SPA0122 3.5e-152 yabC; putative S-adenosyl meTHIonine adenyltransferase K03438; COG: COG0275 Predicted S-adenosylmeTHIonine-dependent methyltransferase involved in cell envelope biogenesis; Psort location: cytoplasmic, score: 23 YP_001439315.1 MraZ; UPF0040; crystal structure shows similarity to AbrB YP_001439316.1 binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism YP_001439317.1 Psort location: cytoplasmic, score: 23 YP_001439318.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit YP_001439319.1 catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive YP_001439320.1 Psort location: cytoplasmic, score: 23 YP_001439321.1 activator for leuABCD operon; member of LysR family of transcriptional activators YP_001439322.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis YP_001439323.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis YP_001439324.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_001439325.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D YP_001439326.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001439327.1 Psort location: mitochondrial, score: 23 YP_001439328.1 activates sgrS under glucose-phosphate stress conditions YP_001439329.1 part of the thiamine and TPP transport system tbpA-thiPQ YP_001439330.1 permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine YP_001439331.1 with TbpA and ThiP is part of the thiamine and TPP transport system YP_001439332.1 KEGG: lsl:LSL_1322 0.0039 alkaline phosphatase K01077; COG: COG0586 Uncharacterized membrane-associated protein; Psort location: endoplasmic reticulum, score: 9 YP_001439333.1 positive and negative regulator; regulates the araBAD and araFGH operons and other genes involved in the transport and catabolism of L-arabinose YP_001439334.1 catalyzes the phosphorylation of ribulose to ribulose 5-phosphate YP_001439335.1 catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism YP_001439336.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source YP_001439337.1 Psort location: mitochondrial, score: 23 YP_001439338.1 Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C YP_001439339.1 transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA YP_001439340.1 catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs YP_001439341.1 functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system YP_001439342.1 determines N-hexane tolerance and is involved in outer membrane permeability YP_001439343.1 Chaperone involved in the folding of extracytoplasmic proteins, especially OmpA, OmpF and LamB YP_001439344.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_001439345.1 protein associated with Co2+ and Mg2+ efflux YP_001439346.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP YP_001439347.1 catalyzes the reduction of dihydrofolate to tetrahydrofolate YP_001439348.1 Psort location: mitochondrial, score: 23 YP_001439349.1 COG: COG1280 Putative threonine efflux protein; Psort location: endoplasmic reticulum, score: 9 YP_001439350.1 transport system that facilitates potassium-efflux YP_001439351.1 Required for full activity of KefC, a potassium-proton antiporter YP_001439352.1 COG: NOG17119 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001439353.1 Psort location: nuclear, score: 23 YP_001439354.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity YP_001439355.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_001439356.1 Psort location: cytoplasmic, score: 23 YP_001439357.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_001439358.1 KEGG: pto:PTO0012 0.0096 isomerizing glucosamine--fructose-6-phosphate aminotransferase K00820; COG: COG1737 Transcriptional regulators; Psort location: mitochondrial, score: 23 YP_001439359.1 COG: NOG06222 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001439360.1 KEGG: lmo:lmo2733 4.7e-205 similar to PTS system, fructose-specific IIABC component K02768:K02769:K02770; COG: COG1299 Phosphotransferase system, fructose-specific IIC component; Psort location: plasma membrane, score: 23 YP_001439361.1 KEGG: lmf:LMOf2365_0421 3.6e-104 glycosyl hydrolase, family 38 K01191; COG: COG0383 Alpha-mannosidase; Psort location: cytoplasmic, score: 23 YP_001439362.1 KEGG: sth:STH1983 3.0e-24 mannnose-6 phospate isomerase K01809; COG: COG1482 Phosphomannose isomerase; Psort location: cytoplasmic, score: 23 YP_001439363.1 KEGG: rru:Rru_A2969 3.3e-14 alanyl-tRNA synthetase related protein K01872; COG: COG2872 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain; Psort location: cytoplasmic, score: 23 YP_001439364.1 KEGG: shn:Shewana3_3435 9.3e-07 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001439365.1 catalyzes the hydrolysis of both purine and pyrimidine ribonucleosides YP_001439366.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway YP_001439367.1 KEGG: sec:SC0042 4.1e-64 slpA; FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase) K03774; COG: COG1047 FKBP-type peptidyl-prolyl cis-trans isomerases 2; Psort location: cytoplasmic, score: 23 YP_001439368.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_001439369.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme YP_001439370.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities YP_001439371.1 COG: COG0268 Ribosomal protein S20; Psort location: nuclear, score: 23 YP_001439372.1 Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC YP_001439373.1 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH YP_001439374.1 KEGG: vfi:VF1598 1.1e-46 exochitinase K01183; COG: COG3325 Chitinase; Psort location: cytoplasmic, score: 23 YP_001439375.1 Psort location: endoplasmic reticulum, score: 9 YP_001439376.1 COG: COG3710 DNA-binding winged-HTH domains; Psort location: vesicles of secretory system, score: 9 YP_001439377.1 COG: COG3926 Putative secretion activating protein; Psort location: cytoplasmic, score: 23 YP_001439378.1 COG: NOG17566 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001439379.1 COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001439380.1 Psort location: mitochondrial, score: 23 YP_001439381.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_001439382.1 COG: NOG10237 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001439383.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_001439384.1 COG: COG1584 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001439385.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001439386.1 forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis YP_001439387.1 KEGG: stt:t0007 3.3e-156 talB; transaldolase B K00616; COG: COG0176 Transaldolase; Psort location: cytoplasmic, score: 23 YP_001439388.1 KEGG: hpa:HPAG1_0925 2.3e-52 D-alanine glycine permease K01613; COG: COG1115 Na+/alanine symporter; Psort location: plasma membrane, score: 23 YP_001439389.1 COG: COG3022 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001439390.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_001439391.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate YP_001439392.1 multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways YP_001439393.1 member of the SPOUT superfamily of methyltransferases YP_001439394.1 KEGG: eci:UTI89_C5174 6.4e-121 arcA; ArcA transcriptional dual regulator K07773; COG: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; Psort location: cytoplasmic, score: 23 YP_001439395.1 COG: COG4452 Inner membrane protein involved in colicin E2 resistance; Psort location: endoplasmic reticulum, score: 23 YP_001439396.1 part of a two-component regulatory system with CreB or PhoB; involved in catabolic regulation YP_001439397.1 response regulator in two-component regulatory system with CreC; CreB protein is phosphorylated by sensor protein phospho-CreC; involved in catabolic regulation YP_001439398.1 COG: COG3045 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001439399.1 KEGG: bat:BAS3585 2.0e-09 Ada regulatory protein/6-O-methylguanine-DNA methyltransferase K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001439400.1 catalyzes reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate YP_001439401.1 pyrophosphatase; has activity against dUTP and dITP; the crystal structure of the Vibrio protein showed similarity to Methanococcus janaschii Mj0226; in Vibrio cholerae this gene is part of the Mba operon that is involved in regulation and maintenance of biofilms; in Escherichia coli overexpression of this gene leads to resistance to an HMP analog YP_001439402.1 When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription YP_001439403.1 catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan YP_001439404.1 Psort location: mitochondrial, score: 23 YP_001439405.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence YP_001439406.1 KEGG: bpm:BURPS1710b_A1960 2.9e-08 putative transport-related membrane protein K00903; COG: COG3524 Capsule polysaccharide export protein; Psort location: endoplasmic reticulum, score: 23 YP_001439407.1 Psort location: nuclear, score: 23 YP_001439408.1 COG: COG1596 Periplasmic protein involved in polysaccharide export; Psort location: extracellular, including cell wall, score: 23 YP_001439409.1 COG: COG3563 Capsule polysaccharide export protein; Psort location: mitochondrial, score: 23 YP_001439410.1 COG: COG3562 Capsule polysaccharide export protein; Psort location: cytoplasmic, score: 23 YP_001439411.1 Psort location: cytoplasmic, score: 23 YP_001439412.1 KEGG: lsa:LSA1576 1.1e-05 tagB; CDP-glycerol:glycerophosphate glycerophosphotransferase (teichoic acid biosynthesis protein B); COG: COG0463 Glycosyltransferases involved in cell wall biogenesis; Psort location: cytoplasmic, score: 23 YP_001439413.1 KEGG: btk:BT9727_5106 4.0e-18 beta-1,3-N-acetylglucosaminyltransferase K00754; COG: COG1887 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC; Psort location: cytoplasmic, score: 23 YP_001439414.1 KEGG: mtu:Rv0806c 1.7e-40 cpsY; possible UDP-glucose-4-epimerase CpsY (galactowaldenase) (UDP-galactose-4-epimerase) (uridine diphosphate galactose-4-epimerase) (uridine diphospho-galactose-4-epimerase) K01784; COG: NOG08826 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001439415.1 KEGG: ecc:c3697 5.6e-90 kpsT; kpsT protein K01990; COG: COG1134 ABC-type polysaccharide/polyol phosphate transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001439416.1 COG: COG1682 ABC-type polysaccharide/polyol phosphate export systems, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001439417.1 KEGG: shn:Shewana3_3435 2.2e-06 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: extracellular, including cell wall, score: 23 YP_001439418.1 KEGG: bur:Bcep18194_A5075 1.1e-84 zinc-containing alcohol dehydrogenase superfamily K00344; COG: COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases; Psort location: cytoplasmic, score: 23 YP_001439419.1 catalyzes the formation of NAD(+) from nicotinamide ribonucleotide YP_001439420.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_001439421.1 catalyzes the formation of serine from O-phosphoserine YP_001439422.1 KEGG: ece:Z5988 1.8e-86 putative lipoate-protein ligase A K03800:K07186; COG: COG3726 Uncharacterized membrane protein affecting hemolysin expression; Psort location: endoplasmic reticulum, score: 23 YP_001439423.1 Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl on the lipoate-dependent enzymes. Creates an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoyl domain of apoproteins YP_001439424.1 KEGG: sty:STY4921 2.4e-121 deoD, pup; purine nucleoside phosphorylase K03784; COG: COG0813 Purine-nucleoside phosphorylase; Psort location: cytoplasmic, score: 23 YP_001439425.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose YP_001439426.1 Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate YP_001439427.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate YP_001439428.1 COG: COG1972 Nucleoside permease; Psort location: plasma membrane, score: 23 YP_001439429.1 KEGG: stm:STM4564 3.6e-95 yjjV; putative hydrolase K03424; COG: COG0084 Mg-dependent DNase; Psort location: mitochondrial, score: 23 YP_001439430.1 KEGG: vfi:VFA0008 8.6e-39 phospholipase; COG: COG4667 Predicted esterase of the alpha-beta hydrolase superfamily; Psort location: cytoplasmic, score: 23 YP_001439431.1 Psort location: nuclear, score: 23 YP_001439432.1 COG: NOG16919 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 23 YP_001439433.1 KEGG: yps:YPTB3710 0.0057 fkpA; peptidyl-prolyl cis-trans isomerase K03772; COG: COG2823 Predicted periplasmic or secreted lipoprotein; Psort location: extracellular, including cell wall, score: 9 YP_001439434.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein YP_001439435.1 manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily YP_001439436.1 alanine acetyltransferase that specifically acetylates ribosomal protein S18 YP_001439437.1 KEGG: stm:STM4557 6.5e-41 holD; DNA polymerase III, psi subunit K02344; COG: COG3050 DNA polymerase III, psi subunit; Psort location: mitochondrial, score: 23 YP_001439438.1 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit YP_001439439.1 COG: NOG09784 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001439440.1 KEGG: ava:Ava_3170 7.3e-26 putative diguanylate cyclase (GGDEF domain) K02488; COG: COG2199 FOG: GGDEF domain; Psort location: endoplasmic reticulum, score: 9 YP_001439441.1 KEGG: gbe:GbCGDNIH1_2380 0.0074 ferric hydroxamate reductase FhuF K00521; COG: COG4114 Uncharacterized Fe-S protein; Psort location: vesicles of secretory system, score: 9 YP_001439442.1 KEGG: eca:ECA2488 5.8e-120 PTS system, cellobiose-specific IIc component K02761; COG: COG1455 Phosphotransferase system cellobiose-specific component IIC; Psort location: plasma membrane, score: 23 YP_001439443.1 KEGG: dvu:DVU1345 4.4e-07 proS, pro; prolyl-tRNA synthetase K01881; COG: COG2606 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001439444.1 regulator for the transport and utilization of the aromatic beta-glucosides arbutin and silicin YP_001439445.1 COG: NOG09075 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001439446.1 COG: COG2966 Uncharacterized conserved protein; Psort location: endoplasmic reticulum, score: 9 YP_001439447.1 COG: COG3610 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001439448.1 COG: COG1846 Transcriptional regulators; Psort location: nuclear, score: 23 YP_001439449.1 KEGG: reh:H16_A1791 3.7e-31 predicted redox protein, regulator of disulfide bond formation K01768; COG: COG1764 Predicted redox protein, regulator of disulfide bond formation; Psort location: cytoplasmic, score: 23 YP_001439450.1 This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' YP_001439451.1 acts to load the DnaB helicase onto the initiation site during DNA replication YP_001439452.1 catalyzes the transfer of phosphoglycerol to the glucan backbone YP_001439453.1 KEGG: lpn:lpg1490 6.4e-34 cyaA; adenylate cyclase PLUS two component hybrid sensor and regulator K01768; COG: COG2199 FOG: GGDEF domain; Psort location: cytoplasmic, score: 23 YP_001439454.1 Psort location: cytoplasmic, score: 23 YP_001439455.1 KEGG: syn:sll1687 1.1e-48 hik17; hypothetical protein; COG: COG2203 FOG: GAF domain; Psort location: endoplasmic reticulum, score: 9 YP_001439456.1 KEGG: syn:sll1871 3.0e-06 hik6; two-component sensor histidine kinase K02486; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 9 YP_001439457.1 Psort location: endoplasmic reticulum, score: 9 YP_001439458.1 KEGG: pen:PSEEN3027 0. serine protease PspB; COG: COG1404 Subtilisin-like serine proteases; Psort location: extracellular, including cell wall, score: 9 YP_001439459.1 KEGG: bam:Bamb_3745 2.5e-183 N-isopropylammelide isopropylaminohydrolase K08710; COG: COG0402 Cytosine deaminase and related metal-dependent hydrolases; Psort location: cytoplasmic, score: 23 YP_001439460.1 COG: COG1457 Purine-cytosine permease and related proteins; Psort location: plasma membrane, score: 23 YP_001439461.1 KEGG: eci:UTI89_C3078 2.0e-229 ascB; 6-phospho-beta-glucosidase K01223; COG: COG2723 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase; Psort location: cytoplasmic, score: 23 YP_001439462.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_001439463.1 KEGG: efa:EF1922 3.3e-12 transcriptional regulator, LacI family/carbohydrate kinase, PfkB family protein K00852; COG: COG1609 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001439464.1 Psort location: extracellular, including cell wall, score: 9 YP_001439465.1 COG: NOG06307 non supervised orthologous group; Psort location: plasma membrane, score: 23 YP_001439466.1 COG: COG1566 Multidrug resistance efflux pump; Psort location: endoplasmic reticulum, score: 9 YP_001439467.1 KEGG: dra:DR0030 0.0098 2-oxoisovalerate dehydrogenase beta subunit K00167; COG: COG1846 Transcriptional regulators; Psort location: nuclear, score: 23 YP_001439468.1 transcriptional repressor of lac operon; forms a homotetramer as a dimer of dimers; binds specific sites in lac operon resulting in DNA looping between the operators; binds allolactose as inducer YP_001439469.1 porin involved in the transport of maltose and maltodextrins YP_001439470.1 KEGG: ypn:YPN_3053 2.3e-29 PTS transport protein K02778; COG: COG1264 Phosphotransferase system IIB components; Psort location: cytoplasmic, score: 23 YP_001439471.1 KEGG: ypm:YP_3549 0. bgaB; puative beta-galactosidase K01190; COG: COG1874 Beta-galactosidase; Psort location: cytoplasmic, score: 23 YP_001439472.1 KEGG: yps:YPTB3098 2.0e-174 putative galactosidase K01224; COG: COG3867 Arabinogalactan endo-1,4-beta-galactosidase; Psort location: extracellular, including cell wall, score: 9 YP_001439473.1 KEGG: cya:CYA_1846 0.00032 modB; molybdate ABC transporter, permease protein K02018; COG: COG3833 ABC-type maltose transport systems, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001439474.1 KEGG: pac:PPA0505 2.7e-05 ABC transporter, putative molybdenum transport system K02017:K02018; COG: COG1175 ABC-type sugar transport systems, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001439475.1 COG: COG2182 Maltose-binding periplasmic proteins/domains; Psort location: extracellular, including cell wall, score: 9 YP_001439476.1 KEGG: bpm:BURPS1710b_1040 3.6e-104 ABC sugar transporter, ATP-binding protein K02023; COG: COG3839 ABC-type sugar transport systems, ATPase components; Psort location: cytoplasmic, score: 23 YP_001439477.1 involved in the degradation of RNA; may be involved in the recycling of RNA during the SOS response YP_001439478.1 COG: COG5457 Uncharacterized conserved small protein; Psort location: cytoplasmic, score: 23 YP_001439479.1 KEGG: bur:Bcep18194_B1266 2.2e-81 transcriptional regulator, GntR family with aminotransferase activity K00825; COG: COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs; Psort location: cytoplasmic, score: 23 YP_001439480.1 COG: COG2733 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001439481.1 Psort location: endoplasmic reticulum, score: 9 YP_001439482.1 COG: COG3209 Rhs family protein; Psort location: cytoplasmic, score: 23 YP_001439483.1 Psort location: cytoplasmic, score: 23 YP_001439484.1 Psort location: cytoplasmic, score: 23 YP_001439485.1 COG: NOG11501 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001439486.1 COG: NOG34707 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001439487.1 COG: NOG26472 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001439488.1 COG: NOG33447 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001439489.1 KEGG: psp:PSPPH_0331 3.7e-22 ubiquinone/menaquinone biosynthesis methyltransferase UbiE K00599; COG: COG0500 SAM-dependent methyltransferases; Psort location: cytoplasmic, score: 23 YP_001439490.1 KEGG: eci:UTI89_C4876 4.2e-156 yjgB; putative oxidoreductase K00100; COG: COG1064 Zn-dependent alcohol dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001439491.1 COG: KOG2813 Predicted molecular chaperone, contains DnaJ domain; Psort location: endoplasmic reticulum, score: 9 YP_001439492.1 KEGG: rle:RL2900 2.8e-65 dhaK; putative dihydroxyacetone kinase K00863; COG: COG2376 Dihydroxyacetone kinase; Psort location: cytoplasmic, score: 23 YP_001439493.1 KEGG: rde:RD1_3702 1.5e-71 dihydroxyacetone kinase K00863; COG: COG2376 Dihydroxyacetone kinase; Psort location: cytoplasmic, score: 23 YP_001439494.1 Psort location: endoplasmic reticulum, score: 23 YP_001439495.1 COG: COG0795 Predicted permeases; Psort location: endoplasmic reticulum, score: 9 YP_001439496.1 COG: COG0795 Predicted permeases; Psort location: endoplasmic reticulum, score: 9 YP_001439497.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides YP_001439498.1 binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB YP_001439499.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_001439500.1 COG: COG4269 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001439501.1 KEGG: stm:STM4473 5.4e-69 yjgM; putative acetyltransferase K03828; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: cytoplasmic, score: 23 YP_001439502.1 Psort location: endoplasmic reticulum, score: 9 YP_001439503.1 KEGG: stm:STM4471 5.5e-108 miaE; hydroxylase for synthesis of 2-methylTHIo-cis-ribozeatin in tRNA K06169; COG: COG4445 Hydroxylase for synthesis of 2-methylTHIo-cis-ribozeatin in tRNA; Psort location: cytoplasmic, score: 23 YP_001439504.1 COG: COG3076 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001439505.1 KEGG: spt:SPA4269 4.4e-154 argI; orniTHIne carbamoyltransferase K00611; COG: COG0078 OrniTHIne carbamoyltransferase; Psort location: cytoplasmic, score: 23 YP_001439506.1 COG: COG2731 Beta-galactosidase, beta subunit; Psort location: cytoplasmic, score: 23 YP_001439507.1 COG: NOG33447 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001439508.1 KEGG: psp:PSPPH_0331 3.7e-22 ubiquinone/menaquinone biosynthesis methyltransferase UbiE K00599; COG: COG0500 SAM-dependent methyltransferases; Psort location: cytoplasmic, score: 23 YP_001439509.1 KEGG: eci:UTI89_C4876 4.2e-156 yjgB; putative oxidoreductase K00100; COG: COG1064 Zn-dependent alcohol dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001439510.1 COG: KOG2813 Predicted molecular chaperone, contains DnaJ domain; Psort location: endoplasmic reticulum, score: 9 YP_001439511.1 KEGG: rle:RL2900 2.7e-145 dhaK; putative dihydroxyacetone kinase K00863; COG: COG2376 Dihydroxyacetone kinase; Psort location: cytoplasmic, score: 23 YP_001439512.1 Psort location: endoplasmic reticulum, score: 23 YP_001439513.1 Psort location: nuclear, score: 23 YP_001439514.1 COG: COG0795 Predicted permeases; Psort location: endoplasmic reticulum, score: 9 YP_001439515.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides YP_001439516.1 binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB YP_001439517.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_001439518.1 COG: COG4269 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001439519.1 KEGG: stm:STM4473 5.4e-69 yjgM; putative acetyltransferase K03828; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: cytoplasmic, score: 23 YP_001439520.1 Psort location: endoplasmic reticulum, score: 9 YP_001439521.1 KEGG: stm:STM4471 5.5e-108 miaE; hydroxylase for synthesis of 2-methylTHIo-cis-ribozeatin in tRNA K06169; COG: COG4445 Hydroxylase for synthesis of 2-methylTHIo-cis-ribozeatin in tRNA; Psort location: cytoplasmic, score: 23 YP_001439522.1 COG: COG3076 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001439523.1 KEGG: spt:SPA4269 4.4e-154 argI; orniTHIne carbamoyltransferase K00611; COG: COG0078 OrniTHIne carbamoyltransferase; Psort location: cytoplasmic, score: 23 YP_001439524.1 COG: COG2731 Beta-galactosidase, beta subunit; Psort location: cytoplasmic, score: 23 YP_001439525.1 Psort location: cytoplasmic, score: 23 YP_001439526.1 catalyzes the degradation of arginine to citruline and ammonia YP_001439527.1 reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP YP_001439528.1 catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway YP_001439529.1 COG: COG1288 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001439530.1 Psort location: mitochondrial, score: 23 YP_001439531.1 COG: COG1438 Arginine repressor; Psort location: cytoplasmic, score: 23 YP_001439532.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis YP_001439533.1 involved in the allosteric regulation of aspartate carbamoyltransferase YP_001439534.1 KEGG: ape:APE_1501.1 1.1e-22 ribonuclease UK114; COG: COG0251 Putative translation initiation inhibitor, yjgF family; Psort location: cytoplasmic, score: 23 YP_001439535.1 KEGG: eci:UTI89_C3435 0. hypothetical protein; COG: COG1032 Fe-S oxidoreductase; Psort location: nuclear, score: 23 YP_001439536.1 KEGG: bur:Bcep18194_C7048 0.0019 ferredoxin/oxidoreductase FAD/NAD(P)-binding K05784; COG: COG2375 Siderophore-interacting protein; Psort location: cytoplasmic, score: 23 YP_001439537.1 Psort location: mitochondrial, score: 23 YP_001439538.1 COG: COG1695 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001439539.1 KEGG: abo:ABO_1307 6.1e-10 sensor histidine kinase/respose regulator; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 9 YP_001439540.1 KEGG: azo:azo3685 8.7e-15 putative hybrid sensor and regulator protein; COG: COG2202 FOG: PAS/PAC domain; Psort location: endoplasmic reticulum, score: 9 YP_001439541.1 KEGG: vfi:VFA0057 5.4e-20 sensor protein; COG: COG2199 FOG: GGDEF domain; Psort location: cytoplasmic, score: 23 YP_001439542.1 Psort location: mitochondrial, score: 23 YP_001439543.1 catalyzes the formation of 4-aminobutyraldehyde from putrescine and 2-oxoglutarate YP_001439544.1 Psort location: cytoplasmic, score: 23 YP_001439545.1 KEGG: stm:STM3219 2.3e-299 fadH; 2,4-dieonyl-CoA reductase K00219; COG: COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001439546.1 KEGG: ecs:ECs3966 4.1e-151 putative ribosomal RNA small subunit methyltransferase D K00564; COG: COG2813 16S RNA G1207 methylase RsmC; Psort location: cytoplasmic, score: 23 YP_001439547.1 COG: COG1451 Predicted metal-dependent hydrolase; Psort location: cytoplasmic, score: 23 YP_001439548.1 COG: COG2949 Uncharacterized membrane protein; Psort location: extracellular, including cell wall, score: 9 YP_001439549.1 KEGG: ecp:ECP_3178 4.3e-140 hypothetical oxidoreductase YgjR; COG: COG0673 Predicted dehydrogenases and related proteins; Psort location: cytoplasmic, score: 23 YP_001439550.1 COG: COG0861 Membrane protein TerC, possibly involved in tellurium resistance; Psort location: plasma membrane, score: 23 YP_001439551.1 involved in the import of serine and threonine coupled with the import of sodium YP_001439552.1 COG: NOG07878 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001439553.1 KEGG: ecp:ECP_3182 7.6e-237 altronate hydrolase K01685; COG: COG2721 Altronate dehydratase; Psort location: cytoplasmic, score: 23 YP_001439554.1 catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism YP_001439555.1 KEGG: fal:FRAAL6577 0.0064 hppA; pyrophosphate-energized proton pump (pyrophosphate-energized inorganic pyrophosphatase) (H+-PPase) (membrane-bound proton-translocating pyrophosphatase) K01507; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001439556.1 regulates the exuT, uxaCA and uxuRAB operons which encode genes involved in hexuronate utilization. YP_001439557.1 KEGG: sab:SAB2386 1.2e-09 probable alkaline phosphatase K01077; COG: COG0586 Uncharacterized membrane-associated protein; Psort location: endoplasmic reticulum, score: 9 YP_001439558.1 Psort location: extracellular, including cell wall, score: 9 YP_001439559.1 KEGG: eci:UTI89_C0735 0.0051 tolA; membrane spanning protein TolA K03646; COG: NOG17164 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001439560.1 COG: COG4575 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001439561.1 COG: COG5393 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001439562.1 COG: NOG11454 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001439563.1 COG: NOG11500 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001439564.1 COG: NOG11500 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001439565.1 Psort location: extracellular, including cell wall, score: 9 YP_001439566.1 COG: COG3188 P pilus assembly protein, porin PapC; Psort location: extracellular, including cell wall, score: 9 YP_001439567.1 member of the periplasmic pilus chaperone family of proteins YP_001439568.1 COG: NOG11500 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001439569.1 COG: NOG11500 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001439570.1 COG: NOG11500 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001439571.1 COG: NOG11500 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001439572.1 KEGG: chu:CHU_2149 0.00014 CHU large protein; candidate retaining b-glycosidase, glycoside hydrolase family 5 protein K01238; COG: NOG11500 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001439573.1 COG: COG2259 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001439574.1 KEGG: eci:UTI89_C3540 7.2e-161 yqjG; putative transferase K07393; COG: COG0435 Predicted glutathione S-transferase; Psort location: cytoplasmic, score: 23 YP_001439575.1 COG: COG3152 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001439576.1 phosphorylates aminoimidazole ribotide (AIR) which forms 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P); synthesis of HMP-P from AIR is complex and requires the product of thiC gene at least YP_001439577.1 COG: COG4580 Maltoporin (phage lambda and maltose receptor); Psort location: extracellular, including cell wall, score: 9 YP_001439578.1 KEGG: ecp:ECP_2752 7.5e-214 PTS system, sucrose-specific IIBC component K02809:K02810; COG: COG1264 Phosphotransferase system IIB components; Psort location: plasma membrane, score: 23 YP_001439579.1 KEGG: ecp:ECP_2753 3.0e-171 sucrose-6-phosphate hydrolase K01193; COG: COG1621 Beta-fructosidases (levanase/invertase); Psort location: vesicles of secretory system, score: 9 YP_001439580.1 KEGG: efa:EF1922 6.6e-07 transcriptional regulator, LacI family/carbohydrate kinase, PfkB family protein K00852; COG: COG1609 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001439581.1 COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001439582.1 COG: COG1741 Pirin-related protein; Psort location: cytoplasmic, score: 23 YP_001439583.1 Psort location: cytoplasmic, score: 23 YP_001439584.1 Psort location: cytoplasmic, score: 23 YP_001439585.1 KEGG: eci:UTI89_C3573 1.7e-136 yraL; hypothetical protein; COG: COG0313 Predicted methyltransferases; Psort location: cytoplasmic, score: 23 YP_001439586.1 KEGG: abo:ABO_1060 0.00024 rne; phosphoric diester hydrolase K08300; COG: COG3107 Putative lipoprotein; Psort location: nuclear, score: 23 YP_001439587.1 Psort location: cytoplasmic, score: 23 YP_001439588.1 KEGG: eci:UTI89_C3574 1.5e-34 yraN; hypothetical protein YraN K07460; COG: COG0792 Predicted endonuclease distantly related to archaeal Holliday junction resolvase; Psort location: cytoplasmic, score: 23 YP_001439589.1 Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein YP_001439590.1 COG: COG2823 Predicted periplasmic or secreted lipoprotein; Psort location: extracellular, including cell wall, score: 9 YP_001439591.1 COG: COG0701 Predicted permeases; Psort location: plasma membrane, score: 23 YP_001439592.1 KEGG: bxe:Bxe_A0199 5.8e-12 hypothetical protein K00329; COG: COG0702 Predicted nucleoside-diphosphate-sugar epimerases; Psort location: cytoplasmic, score: 23 YP_001439593.1 KEGG: ecp:ECP_3241 1.5e-80 hypothetical protein YhbO (hypothetical protease) K05520; COG: COG0693 Putative intracellular protease/amidase; Psort location: cytoplasmic, score: 23 YP_001439594.1 COG: COG3787 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001439595.1 KEGG: mca:MCA0838 0.0011 type I restriction-modification system, R subunit K01153; COG: COG2827 Predicted endonuclease containing a URI domain; Psort location: cytoplasmic, score: 23 YP_001439596.1 KEGG: sec:SC3213 9.8e-70 yhbS; putative ABC superfamily (membrane) transport protein K03824; COG: COG3153 Predicted acetyltransferase; Psort location: cytoplasmic, score: 23 YP_001439597.1 COG: COG3154 Putative lipid carrier protein; Psort location: cytoplasmic, score: 23 YP_001439598.1 KEGG: ecp:ECP_3246 5.2e-167 putative protease YhbU precursor K08303; COG: COG0826 Collagenase and related proteases; Psort location: cytoplasmic, score: 23 YP_001439599.1 KEGG: eci:UTI89_C3586 1.8e-132 yhbV; hypothetical protein YhbV K01423; COG: COG0826 Collagenase and related proteases; Psort location: cytoplasmic, score: 23 YP_001439600.1 KEGG: eci:UTI89_C3587 1.4e-159 yhbW; hypothetical protein K00494; COG: COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases; Psort location: extracellular, including cell wall, score: 9 YP_001439601.1 tryptophan transporter of high affinity YP_001439602.1 Psort location: cytoplasmic, score: 23 YP_001439604.1 participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division YP_001439605.1 lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing YP_001439606.1 Psort location: cytoplasmic, score: 23 YP_001439607.1 KEGG: eci:UTI89_C3594 0. pnp; polyribonucleotide nucleotidyltransferase K00962; COG: COG1185 Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase); Psort location: cytoplasmic, score: 23 YP_001439608.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs YP_001439609.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock YP_001439610.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_001439611.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_001439612.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins YP_001439613.1 KEGG: lpn:lpg1509 0.0046 D-alanyl-D-alanine carboxypeptidase K07258; COG: COG1314 Preprotein translocase subunit SecG; Psort location: endoplasmic reticulum, score: 9 YP_001439614.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_001439615.1 catalyzes the formation of dihydropteroate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate YP_001439616.1 inner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins YP_001439617.1 Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit YP_001439618.1 RNA binding protein found associated to pre-50S subunit of the ribosome; putative role in ribosome assembly; necessary for optimal growth but not cell viability YP_001439619.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_001439620.1 penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains YP_001439621.1 response regulator in two-component regulatory system with BasS YP_001439622.1 KEGG: yps:YPTB0468 2.7e-113 basS, prmB; two-component system sensor protein K07643; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 9 YP_001439623.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_001439624.1 COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: plasma membrane, score: 23 YP_001439625.1 involved in the peptidyltransferase reaction during translation YP_001439626.1 KEGG: bba:Bd0348 0.0092 acyltransferase K00655; Psort location: cytoplasmic, score: 23 YP_001439627.1 KEGG: sfx:S3445 8.2e-153 ispB; octaprenyl diphosphate synthase K02523; COG: COG0142 Geranylgeranyl pyrophosphate synthase; Psort location: cytoplasmic, score: 23 YP_001439628.1 activator of maltose metabolism genes YP_001439629.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_001439630.1 COG: COG5007 Predicted transcriptional regulator, BolA superfamily; Psort location: cytoplasmic, score: 23 YP_001439631.1 COG: COG3113 Predicted NTP binding protein (contains STAS domain); Psort location: cytoplasmic, score: 23 YP_001439632.1 COG: COG2854 ABC-type transport system involved in resistance to organic solvents, auxiliary component; Psort location: extracellular, including cell wall, score: 9 YP_001439633.1 COG: COG1463 ABC-type transport system involved in resistance to organic solvents, periplasmic component; Psort location: endoplasmic reticulum, score: 9 YP_001439634.1 COG: COG0767 ABC-type transport system involved in resistance to organic solvents, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001439635.1 ATP-binding subunit of a putative ABC toluene efflux transporter YP_001439636.1 YrbG; inner membrane protein involved in cell envelope integrity; putative sodium ion/calcium ion exchanger; in E. coli it is non essential for cell viability; member of the YRBG family of cation/Ca2+ exchangers YP_001439637.1 KEGG: sec:SC3253 6.1e-148 yrbH; putative polysialic acid capsule expression protein K06041; COG: COG0794 Predicted sugar phosphate isomerase involved in capsule formation; Psort location: cytoplasmic, score: 23 YP_001439638.1 forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis YP_001439639.1 COG: COG3117 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001439640.1 LptA; periplasmic binding protein part of a putative ABC superfamily of uptake transporters; interacts with LptB protein, the ATP binding component of the uptake system YP_001439641.1 KEGG: pen:PSEEN1094 8.8e-85 ABC transporter, ATP-binding protein; COG: COG1137 ABC-type (unclassified) transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001439642.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen YP_001439643.1 YhbH; resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase; binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization); seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing YP_001439644.1 KEGG: stm:STM3322 1.2e-73 ptsN; sugar specific PTS family, enzyme IIA, also regulates N metabolism K02806; COG: COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type); Psort location: nuclear, score: 23 YP_001439645.1 KEGG: reh:H16_A0381 2.6e-60 predicted P-loop-containing kinase K01009; COG: COG1660 Predicted P-loop-containing kinase; Psort location: cytoplasmic, score: 23 YP_001439646.1 KEGG: aha:AHA_3919 1.6e-28 multiphosphoryl transfer protein (MTP) K00924; COG: COG1925 Phosphotransferase system, HPr-related proteins; Psort location: cytoplasmic, score: 23 YP_001439647.1 glycosyltransferase; polymerizes glycan strands in the peptidoglycan YP_001439648.1 KEGG: gvi:glr2813 0.00078 probable protease K05520; COG: COG3155 Uncharacterized protein involved in an early stage of isoprenoid biosynthesis; Psort location: endoplasmic reticulum, score: 9 YP_001439649.1 sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA YP_001439650.1 KEGG: eci:UTI89_C3647 2.1e-131 yhcC; hypothetical protein; COG: COG1242 Predicted Fe-S oxidoreductase; Psort location: cytoplasmic, score: 23 YP_001439651.1 Psort location: cytoplasmic, score: 23 YP_001439652.1 catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate YP_001439653.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate YP_001439654.1 KEGG: eci:UTI89_C2514 9.0e-52 yfaL; hypothetical protein YfaL precursor K07279; COG: COG3210 Large exoproteins involved in heme utilization or adhesion; Psort location: cytoplasmic, score: 23 YP_001439655.1 COG: COG2731 Beta-galactosidase, beta subunit; Psort location: cytoplasmic, score: 23 YP_001439656.1 catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein YP_001439657.1 KEGG: cal:orf19.6141 3.4e-05 HXT1; high-affinity hexose (glucose) transporter K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001439658.1 catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid YP_001439659.1 Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization YP_001439660.1 COG: COG2969 Stringent starvation protein B; Psort location: cytoplasmic, score: 23 YP_001439661.1 transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation YP_001439662.1 forms a direct contact with the tRNA during translation YP_001439663.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_001439664.1 KEGG: reh:H16_A2322 4.1e-71 ATPase K01529; COG: COG1485 Predicted ATPase; Psort location: cytoplasmic, score: 23 YP_001439665.1 KEGG: eco:b3233 2.6e-62 yhcB; hypothetical protein K00424; COG: COG3105 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001439666.1 KEGG: spt:SPA3215 1.6e-202 degQ; serine protease K04772; COG: COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain; Psort location: extracellular, including cell wall, score: 9 YP_001439667.1 KEGG: ecc:c3990 1.0e-154 degS; protease degS precursor K04691; COG: COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain; Psort location: extracellular, including cell wall, score: 9 YP_001439668.1 oxidizes malate to oxaloacetate YP_001439669.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes YP_001439670.1 KEGG: tko:TK0217 0.0036 pyridoxine/pyridoxal 5-phosphate biosynthesis protein, SOR/SNZ family K06215; COG: NOG12178 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001439671.1 COG: NOG30709 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001439672.1 COG: COG2732 Barstar, RNAse (barnase) inhibitor; Psort location: cytoplasmic, score: 23 YP_001439673.1 KEGG: eca:ECA0280 7.1e-131 succinate-semialdehyde dehydrogenase [NADP+] K00135; COG: COG1012 NAD-dependent aldehyde dehydrogenases; Psort location: extracellular, including cell wall, score: 9 YP_001439674.1 with AaeA forms an efflux pump whose substrates are p-hydroxybenzoic acid 6-hydroxy-2-naphthoic and 2-hydroxycinnamate YP_001439675.1 with AaeB forms an efflux pump whose substrates are p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic and 2-hydroxycinnamate YP_001439676.1 membrane protein AaeX; the gene is a member of the aaeXAB operon YP_001439677.1 KEGG: shn:Shewana3_3435 3.5e-09 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001439678.1 responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase; degrades the E. coli plasmid F-encoded CcdA YP_001439679.1 COG: COG3164 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001439680.1 involved in the processing of the 5'end of 16S rRNA YP_001439681.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell YP_001439682.1 part of cell wall structural complex MreBCD; transmembrane component YP_001439683.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall YP_001439684.1 functions in MreBCD complex in some organisms YP_001439685.1 regulates the degradation of the small RNAs CsrB and CsrC; may function to targate RNase E to specific RNA molecules YP_001439686.1 KEGG: eci:UTI89_C3684 1.1e-139 yhdH; protein YhdH K00001; COG: COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases; Psort location: endoplasmic reticulum, score: 9 YP_001439687.1 in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ YP_001439688.1 in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme YP_001439689.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis YP_001439690.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_001439691.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_001439692.1 KEGG: spj:MGAS2096_Spy0220 0.0075 fasC; sensory transduction protein kinase FasC; COG: COG3924 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001439693.1 mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase YP_001439694.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype YP_001439695.1 Psort location: endoplasmic reticulum, score: 9 YP_001439696.1 KEGG: sec:SC3322 5.7e-161 yhdG, nifR3; putative TIM-barrel enzyme, possibly dehydrogenase K05540; COG: COG0042 tRNA-dihydrouridine synthase; Psort location: mitochondrial, score: 23 YP_001439697.1 Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription YP_001439698.1 KEGG: shn:Shewana3_3829 4.2e-95 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) K01745; COG: COG2199 FOG: GGDEF domain; Psort location: plasma membrane, score: 23 YP_001439699.1 COG: COG1309 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001439700.1 Psort location: nuclear, score: 23 YP_001439701.1 COG: COG0845 Membrane-fusion protein; Psort location: extracellular, including cell wall, score: 9 YP_001439702.1 COG: NOG14133 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001439703.1 Psort location: nuclear, score: 23 YP_001439704.1 KEGG: bur:Bcep18194_A4762 3.0e-16 ABC amino acid transporter, periplasmic ligand binding protein K01713; COG: COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; Psort location: endoplasmic reticulum, score: 9 YP_001439705.1 KEGG: sma:SAV6546 1.6e-17 putative ABC transporter permease K02028; COG: COG4597 ABC-type amino acid transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001439706.1 KEGG: sma:SAV6546 1.1e-22 putative ABC transporter permease K02028; COG: COG0765 ABC-type amino acid transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001439707.1 KEGG: ecs:ECs4144 9.9e-125 putative ATP-binding component of a transport system K02028; COG: COG1126 ABC-type polar amino acid transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001439710.1 involved in de novo purine biosynthesis YP_001439711.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_001439712.1 COG: NOG06219 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001439713.1 histone-like DNA-binding protein YP_001439714.1 COG: COG3068 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001439715.1 Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA; cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures YP_001439716.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III YP_001439717.1 can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates YP_001439718.1 binds specifically to the major sigma factor sigma 70; active in stationary phase YP_001439719.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine YP_001439720.1 catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate YP_001439721.1 KEGG: eci:UTI89_C3827 4.6e-95 THIF; adenylyltransferase ThiF K03148; COG: COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and THIamine biosynthesis family 2; Psort location: cytoplasmic, score: 23 YP_001439722.1 COG: COG2104 Sulfur transfer protein involved in THIamine biosynthesis; Psort location: cytoplasmic, score: 23 YP_001439723.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate YP_001439724.1 in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center YP_001439725.1 KEGG: plu:plu2754 4.8e-29 celA; PTS system, cellobiose-specific IIB component K02760; COG: COG1440 Phosphotransferase system cellobiose-specific component IIB; Psort location: cytoplasmic, score: 23 YP_001439726.1 KEGG: plu:plu2756 1.2e-32 celC; PTS system, cellobiose-specific IIA component (EIIA-CEL) (cellobiose-permease IIA component) (phosphotransferase enzyme II, A component) (EIII-CEL) K02759; COG: COG1447 Phosphotransferase system cellobiose-specific component IIA; Psort location: cytoplasmic, score: 23 YP_001439727.1 KEGG: reh:H16_B2551 1.4e-07 alkA; DNA-3-methyladenine glycosylase II, adenosine deaminase K01247; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: plasma membrane, score: 23 YP_001439728.1 KEGG: xcb:XC_1376 2.2e-05 putative carboxymethylenebutenolidase K01061; COG: COG4188 Predicted dienelactone hydrolase; Psort location: extracellular, including cell wall, score: 9 YP_001439729.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_001439730.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_001439731.1 Psort location: mitochondrial, score: 23 YP_001439732.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_001439733.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_001439734.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_001439735.1 Psort location: mitochondrial, score: 23 YP_001439736.1 binds directly to 23S ribosomal RNA YP_001439737.1 Modulates Rho-dependent transcription termination YP_001439738.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_001439739.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_001439740.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis YP_001439741.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon YP_001439743.1 catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX YP_001439744.1 KEGG: shn:Shewana3_0031 1.1e-77 potassium uptake protein, TrkH family K00961; COG: COG0168 Trk-type K+ transport systems, membrane components; Psort location: plasma membrane, score: 23 YP_001439745.1 KEGG: eci:UTI89_C4433 4.6e-79 yigZ; hypothetical protein K00560; COG: COG1739 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001439746.1 catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters YP_001439747.1 includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids YP_001439748.1 FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids YP_001439749.1 Psort location: extracellular, including cell wall, score: 9 YP_001439750.1 NAD(P)H-flavin reductase; catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide; in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin YP_001439751.1 catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol YP_001439752.1 COG: COG0250 Transcription antiterminator; Psort location: mitochondrial, score: 23 YP_001439753.1 KEGG: fal:FRAAL1637 0.0012 alcohol dehydrogenase K00001; Psort location: extracellular, including cell wall, score: 9 YP_001439754.1 magnesium dependent; not involved in the Sec-independent protein export system YP_001439755.1 with TatABE forms the twin-arginine translocation complex which is involved in the transport of proteins across the cytoplasmic membrane YP_001439756.1 mediates the export of protein precursors bearing twin-arginine signal peptides YP_001439757.1 COG: COG1826 Sec-independent protein secretion pathway components; Psort location: cytoplasmic, score: 23 YP_001439758.1 an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions YP_001439759.1 COG: COG3165 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001439760.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone YP_001439761.1 YigN; nuclease that may cleave DNA structures arising during the recombination of short-inverted repeats and thereby prevents the inversion of the internal sequence; transcription is induced by DNA-damaging agents such as nalidixic acid or mitomycin C in a LexA-dependent manner YP_001439762.1 catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway YP_001439763.1 KEGG: stm:STM3967 3.3e-124 dlhH; putative dienelactone hydrolase family K01061; COG: COG0412 Dienelactone hydrolase and related enzymes; Psort location: cytoplasmic, score: 23 YP_001439764.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine YP_001439765.1 KEGG: shn:Shewana3_3435 1.9e-14 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001439766.1 COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: plasma membrane, score: 23 YP_001439767.1 purine and pyrimidine nucleotides are secondary substrates; yigL expression is regulated by heat shock, osmotic shock and starvation of glucose, phosphate or ammonium YP_001439768.1 lecithinase B; catalyzes the conversion of 1-lysophosphatidylcholine to glycerophosphocholine; can also hydrolyze 2-acyl glycerophosphoethanolamine and other substrates YP_001439769.1 COG: COG1280 Putative threonine efflux protein; Psort location: endoplasmic reticulum, score: 9 YP_001439770.1 COG: COG1280 Putative threonine efflux protein; Psort location: endoplasmic reticulum, score: 9 YP_001439771.1 functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway YP_001439772.1 catalyzes the hydrolysis of phosphatidylcholine YP_001439773.1 COG: COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism; Psort location: cytoplasmic, score: 23 YP_001439774.1 COG: COG2962 Predicted permeases; Psort location: endoplasmic reticulum, score: 23 YP_001439775.1 Psort location: endoplasmic reticulum, score: 9 YP_001439776.1 COG: NOG09851 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001439777.1 responsible for the influx of magnesium ions YP_001439778.1 unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair. YP_001439779.1 KEGG: bur:Bcep18194_B2556 2.5e-25 HAD-superfamily hydrolase, subfamily IA, variant 1 K01560; COG: COG1011 Predicted hydrolase (HAD superfamily); Psort location: cytoplasmic, score: 23 YP_001439780.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_001439781.1 KEGG: azo:azo0595 1.0e-06 3',5'-cyclic-nucleotide phosphodiesterase K01120; COG: COG3159 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001439782.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate YP_001439783.1 COG: COG5567 Predicted small periplasmic lipoprotein; Psort location: extracellular, including cell wall, score: 9 YP_001439784.1 defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly YP_001439785.1 catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP YP_001439786.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis YP_001439787.1 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis YP_001439788.1 KEGG: spt:SPA3777 6.6e-151 hemX; uroporphyrinogen III methylase K02496; COG: COG2959 Uncharacterized enzyme of heme biosynthesis; Psort location: nuclear, score: 23 YP_001439789.1 COG: COG3071 Uncharacterized enzyme of heme biosynthesis; Psort location: endoplasmic reticulum, score: 9 YP_001439790.1 KEGG: ava:Ava_4160 4.1e-34 VCBS K01317; COG: COG5295 Autotransporter adhesin; Psort location: cytoplasmic, score: 23 YP_001439791.1 Psort location: mitochondrial, score: 23 YP_001439792.1 uncharacterized member of the amino acid-polyamine-organocation (APC) superfamily of amino acid transporters; unknown function YP_001439793.1 KEGG: ecc:c4716 3.6e-111 wecG; probable UDP-N-acetyl-D-mannosaminuronic acid transferase K02852; COG: COG1922 Teichoic acid biosynthesis proteins; Psort location: cytoplasmic, score: 23 YP_001439794.1 enterobacterial common antigen polymerase YP_001439795.1 catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis YP_001439796.1 COG: COG2244 Membrane protein involved in the export of O-antigen and teichoic acid; Psort location: plasma membrane, score: 23 YP_001439797.1 catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis YP_001439798.1 KEGG: eci:UTI89_C4346 2.3e-70 rffC, rff, wecD, yifH; TDP-fucosamine acetyltransferase K00680; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: cytoplasmic, score: 23 YP_001439799.1 catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid YP_001439800.1 KEGG: eci:UTI89_C4342 3.2e-167 rffE, yifF, nfrC, wecB; UDP-N-acetylglucosamine 2-epimerase K01791; COG: COG0381 UDP-N-acetylglucosamine 2-epimerase; Psort location: cytoplasmic, score: 23 YP_001439801.1 Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein YP_001439802.1 KEGG: ssn:SSO_3956 2.6e-172 rfe; UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase K02851; COG: COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase; Psort location: plasma membrane, score: 23 YP_001439803.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_001439804.1 KEGG: eci:UTI89_C4335 4.7e-54 trxA; THIoredoxin 1 K03671; COG: COG0526 Thiol-disulfide isomerase and THIoredoxins; Psort location: cytoplasmic, score: 23 YP_001439805.1 enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation YP_001439806.1 catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation YP_001439807.1 single-stranded DNA-dependent ATPase; initiates unwinding at a nick in the DNA; involved in DNA replication YP_001439808.1 KEGG: spt:SPA3749 1.8e-45 ppiC; peptidyl-prolyl cis-trans isomerase C K03769; COG: COG0760 Parvulin-like peptidyl-prolyl isomerase; Psort location: cytoplasmic, score: 23 YP_001439809.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_001439810.1 Psort location: cytoplasmic, score: 23 YP_001439811.1 participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate YP_001439812.1 threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway YP_001439813.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_001439814.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_001439815.1 KEGG: ypn:YPN_0067 1.4e-29 acetolactate synthase isozyme II small subunit K01653; COG: COG3978 Acetolactate synthase (isozyme II), small (regulatory) subunit; Psort location: cytoplasmic, score: 23 YP_001439816.1 catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit YP_001439817.1 KEGG: eci:UTI89_C4322 3.7e-212 yifB; putative 2-component regulator K07391; COG: COG0606 Predicted ATPase with chaperone activity; Psort location: endoplasmic reticulum, score: 9 YP_001439818.1 COG: COG3085 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001439819.1 Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon YP_001439821.1 converts L-glutamate to D-glutamate, a component of peptidoglycan YP_001439822.1 involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space YP_001439823.1 catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs YP_001439824.1 COG: NOG10261 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001439825.1 negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis YP_001439826.1 catalyzes the conversion of NADPH to NADH YP_001439827.1 Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA YP_001439828.1 catalyzes the formation of arginine from (N-L-arginino)succinate YP_001439829.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming YP_001439830.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate YP_001439831.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate YP_001439832.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis YP_001439833.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate YP_001439834.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: cytoplasmic, score: 23 YP_001439835.1 COG: COG3188 P pilus assembly protein, porin PapC; Psort location: extracellular, including cell wall, score: 9 YP_001439836.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: extracellular, including cell wall, score: 9 YP_001439837.1 KEGG: bme:BMEII0148 0.0069 extracellular serine protease; COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: endoplasmic reticulum, score: 9 YP_001439838.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate YP_001439839.1 KEGG: bba:Bd3613 1.6e-19 sensory transduction histidine kinase; COG: COG2202 FOG: PAS/PAC domain; Psort location: cytoplasmic, score: 23 YP_001439840.1 Psort location: cytoplasmic, score: 23 YP_001439841.1 Psort location: cytoplasmic, score: 23 YP_001439842.1 MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor YP_001439843.1 multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways YP_001439844.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine YP_001439845.1 when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis YP_001439846.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_001439847.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity YP_001439848.1 negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins YP_001439849.1 KEGG: rno:309804 4.3e-08 Cdc2l6_predicted; cell division cycle 2-like 6 (CDK8-like) (predicted) K02208; COG: COG3087 Cell division protein; Psort location: nuclear, score: 23 YP_001439850.1 heat shock protein involved in degradation of misfolded proteins YP_001439851.1 heat shock protein involved in degradation of misfolded proteins YP_001439852.1 Psort location: extracellular, including cell wall, score: 9 YP_001439853.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate YP_001439854.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity YP_001439855.1 COG: COG3074 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001439856.1 COG: COG0580 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family); Psort location: endoplasmic reticulum, score: 9 YP_001439857.1 KEGG: sec:SC3975 6.5e-263 glpK; glycerol kinase K00864; COG: COG0554 Glycerol kinase; Psort location: cytoplasmic, score: 23 YP_001439858.1 COG: NOG10267 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001439859.1 COG: NOG17530 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001439860.1 COG: COG4679 Phage-related protein; Psort location: cytoplasmic, score: 23 YP_001439861.1 COG: COG1620 L-lactate permease; Psort location: plasma membrane, score: 23 YP_001439862.1 represses the lctPRD operon YP_001439863.1 flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration YP_001439864.1 COG: COG2258 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001439865.1 SodA; manganese binding; only present under aerobic conditions; destroys free radicals YP_001439866.1 transports L-rhamnose and L-lyxose into the cell YP_001439867.1 KEGG: bli:BL05281 1.2e-09 adaA; methylphosphotriester-DNA alkyltransferase and transcriptional regulator (AraC/XylS family) K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001439868.1 activates the expression of the rhaBAD operon and rhaT gene YP_001439869.1 KEGG: ecj:JW3875 6.5e-144 rhaB; rhamnulokinase K00848; COG: COG1070 Sugar (pentulose and hexulose) kinases; Psort location: cytoplasmic, score: 23 YP_001439870.1 KEGG: sec:SC3937 6.6e-32 rhaB; rhamnulokinase K00848; COG: COG1070 Sugar (pentulose and hexulose) kinases; Psort location: cytoplasmic, score: 23 YP_001439871.1 catalyzes the formation of L-rhamnulose from L-rhamnose YP_001439872.1 KEGG: eca:ECA0438 1.6e-117 rhaD; rhamnulose-1-phosphate aldolase K01629; COG: COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases; Psort location: cytoplasmic, score: 23 YP_001439873.1 KEGG: sty:STY3830 1.3e-175 alcohol dehydrogenase K00001; COG: COG1454 Alcohol dehydrogenase, class IV; Psort location: cytoplasmic, score: 23 YP_001439874.1 KEGG: msm:MSMEG_0587 5.1e-09 rhaU; L-rhamnose 1-epimerase; COG: COG3254 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001439875.1 lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments YP_001439876.1 KEGG: eca:ECA0754 2.2e-278 rafA; alpha-galactosidase K07407; COG: COG3345 Alpha-galactosidase; Psort location: cytoplasmic, score: 23 YP_001439877.1 COG: COG1609 Transcriptional regulators; Psort location: extracellular, including cell wall, score: 9 YP_001439878.1 KEGG: psp:PSPPH_2917 2.7e-08 DNA-binding protein K00517; COG: COG1396 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001439879.1 COG: COG1296 Predicted branched-chain amino acid permease (azaleucine resistance); Psort location: endoplasmic reticulum, score: 9 YP_001439880.1 COG: NOG19750 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001439881.1 Psort location: extracellular, including cell wall, score: 9 YP_001439882.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth YP_001439883.1 KEGG: ecc:c5624 3.8e-100 fdoG; formate dehydrogenase-O, major subunit K00123; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: extracellular, including cell wall, score: 9 YP_001439884.1 KEGG: sty:STY3839 0. fdoG; formate dehydrogenase-O, major subunit K00123; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: cytoplasmic, score: 23 YP_001439885.1 KEGG: stm:STM4036 1.9e-162 fdoH; formate dehydrogenase-O, Fe-S subunit K00124; COG: COG0437 Fe-S-cluster-containing hydrogenase components 1; Psort location: cytoplasmic, score: 23 YP_001439886.1 cytochrome b556(FDO) component; heme containing YP_001439887.1 required for the formation of active formate dehydrogenase YP_001439888.1 COG: COG2944 Predicted transcriptional regulator; Psort location: nuclear, score: 23 YP_001439889.1 COG: COG2026 Cytotoxic translational repressor of toxin-antitoxin stability system; Psort location: cytoplasmic, score: 23 YP_001439890.1 KEGG: bha:BH0394 3.7e-07 adaA; methylphosphotriester-DNA alkyltransferase (AraC/XylS family) K00567; COG: COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain; Psort location: cytoplasmic, score: 23 YP_001439891.1 KEGG: eci:UTI89_C4210 4.6e-72 yicJ; hypothetical symporter YicJ K03292; COG: COG2211 Na+/melibiose symporter and related transporters; Psort location: plasma membrane, score: 23 YP_001439892.1 COG: COG3533 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001439893.1 COG: COG1280 Putative threonine efflux protein; Psort location: plasma membrane, score: 23 YP_001439894.1 KEGG: fnu:FN1474 1.7e-40 N-acetylmannosamine kinase K00885; COG: COG1940 Transcriptional regulator/sugar kinase; Psort location: cytoplasmic, score: 23 YP_001439895.1 KEGG: ecc:c4410 1.1e-155 yiaY; probable alcohol dehydrogenase K00001; COG: COG1454 Alcohol dehydrogenase, class IV; Psort location: cytoplasmic, score: 23 YP_001439896.1 KEGG: eci:UTI89_C4132 2.8e-246 selB; selenocysteine-specific elongation factor K03833; COG: COG3276 Selenocysteine-specific translation elongation factor; Psort location: cytoplasmic, score: 23 YP_001439897.1 catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis YP_001439898.1 KEGG: eci:UTI89_C4134 1.2e-80 yibF; putative S-transferase K00799; COG: COG0625 glutathione S-transferase; Psort location: cytoplasmic, score: 23 YP_001439899.1 KEGG: stm:STM3685 0. mtlA; PTS family, mannitol-specific enzyme IIABC components K02798:K02799:K02800; COG: COG4668 Mannitol/fructose-specific phosphotransferase system, IIA domain; Psort location: plasma membrane, score: 23 YP_001439900.1 KEGG: stm:STM3686 6.7e-174 mtlD; mannitol-1-phosphate dehydrogenase K00009; COG: COG0246 Mannitol-1-phosphate/altronate dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001439901.1 Acts as a repressor of the mtlAD operon YP_001439902.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese YP_001439903.1 KEGG: ssn:SSO_4093 2.7e-115 fpr; ferredoxin-NADP reductase K00528; COG: COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1; Psort location: cytoplasmic, score: 23 YP_001439904.1 COG: COG3152 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001439905.1 Psort location: cytoplasmic, score: 23 YP_001439906.1 COG: NOG06218 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001439907.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate YP_001439908.1 COG: COG5435 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001439909.1 Psort location: cytoplasmic, score: 23 YP_001439910.1 Psort location: cytoplasmic, score: 23 YP_001439911.1 Psort location: cytoplasmic, score: 23 YP_001439912.1 Psort location: cytoplasmic, score: 23 YP_001439913.1 COG: COG3209 Rhs family protein; Psort location: cytoplasmic, score: 23 YP_001439914.1 Psort location: cytoplasmic, score: 23 YP_001439915.1 Psort location: cytoplasmic, score: 23 YP_001439916.1 Psort location: cytoplasmic, score: 23 YP_001439917.1 Psort location: cytoplasmic, score: 23 YP_001439918.1 Psort location: cytoplasmic, score: 23 YP_001439919.1 Psort location: nuclear, score: 23 YP_001439920.1 Psort location: cytoplasmic, score: 23 YP_001439921.1 KEGG: sph:MGAS10270_Spy0598 0.00014 streptodornase K01150; COG: COG3209 Rhs family protein; Psort location: cytoplasmic, score: 23 YP_001439922.1 Psort location: cytoplasmic, score: 23 YP_001439923.1 Psort location: cytoplasmic, score: 23 YP_001439924.1 Psort location: cytoplasmic, score: 23 YP_001439925.1 COG: COG3209 Rhs family protein; Psort location: endoplasmic reticulum, score: 9 YP_001439926.1 COG: COG5435 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001439927.1 COG: COG3501 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001439928.1 Psort location: mitochondrial, score: 23 YP_001439929.1 Psort location: cytoplasmic, score: 23 YP_001439930.1 Psort location: cytoplasmic, score: 23 YP_001439931.1 Psort location: nuclear, score: 23 YP_001439932.1 Psort location: extracellular, including cell wall, score: 9 YP_001439933.1 COG: COG3209 Rhs family protein; Psort location: cytoplasmic, score: 23 YP_001439934.1 Psort location: cytoplasmic, score: 23 YP_001439935.1 KEGG: rpa:RPA3229 0.00054 adk; adenylate kinase K00939; COG: COG3209 Rhs family protein; Psort location: cytoplasmic, score: 23 YP_001439936.1 KEGG: psp:PSPPH_1820 0.00019 ankyrin domain protein; COG: COG0666 FOG: Ankyrin repeat; Psort location: nuclear, score: 23 YP_001439937.1 KEGG: xcv:XCV3039 4.0e-16 putative phospholipase A1 K01058; COG: COG4104 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001439938.1 COG: COG5351 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001439939.1 KEGG: pfa:PFD0565c 2.9e-06 RNA helicase, putative K01509; COG: COG3501 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001439940.1 KEGG: dre:352910 1.3e-07 mib; mind bomb K01932; COG: COG0666 FOG: Ankyrin repeat; Psort location: extracellular, including cell wall, score: 9 YP_001439941.1 KEGG: xcv:XCV3039 6.4e-14 putative phospholipase A1 K01058; COG: COG4104 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001439942.1 KEGG: bte:BTH_II0256 3.5e-79 serine/threonine protein kinase K00870; COG: COG0515 Serine/threonine protein kinase; Psort location: endoplasmic reticulum, score: 9 YP_001439943.1 KEGG: bte:BTH_I2958 2.0e-238 ClpA/B type protease K01358; COG: COG0542 ATPases with chaperone activity, ATP-binding subunit; Psort location: endoplasmic reticulum, score: 9 YP_001439944.1 COG: COG3520 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001439945.1 COG: COG3519 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001439946.1 COG: COG3518 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001439947.1 COG: COG4455 Protein of avirulence locus involved in temperature-dependent protein secretion; Psort location: cytoplasmic, score: 23 YP_001439948.1 COG: NOG10802 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001439949.1 KEGG: tte:TTE1501 3.8e-20 ptc1; protein serine/threonine phosphatases K01090; COG: COG0631 Serine/threonine protein phosphatase; Psort location: cytoplasmic, score: 23 YP_001439950.1 KEGG: rno:85238 2.6e-07 Synj1; synaptojanin 1 K01099; COG: COG3456 Uncharacterized conserved protein, contains FHA domain; Psort location: nuclear, score: 23 YP_001439951.1 Psort location: endoplasmic reticulum, score: 9 YP_001439952.1 COG: NOG13310 non supervised orthologous group; Psort location: vesicles of secretory system, score: 9 YP_001439953.1 Psort location: extracellular, including cell wall, score: 9 YP_001439954.1 Psort location: extracellular, including cell wall, score: 9 YP_001439955.1 Psort location: extracellular, including cell wall, score: 9 YP_001439956.1 COG: COG3157 Hemolysin-coregulated protein (uncharacterized); Psort location: cytoplasmic, score: 23 YP_001439957.1 COG: NOG17434 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001439958.1 COG: NOG22256 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001439959.1 Psort location: cytoplasmic, score: 23 YP_001439960.1 Psort location: cytoplasmic, score: 23 YP_001439961.1 Psort location: extracellular, including cell wall, score: 9 YP_001439962.1 KEGG: bpm:BURPS1710b_A0534 1.7e-95 hypothetical protein K00356; COG: COG3517 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001439963.1 Psort location: mitochondrial, score: 23 YP_001439964.1 COG: COG3516 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001439965.1 COG: COG3515 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001439966.1 COG: COG3913 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001439967.1 COG: COG3523 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001439968.1 COG: COG1360 Flagellar motor protein; Psort location: endoplasmic reticulum, score: 9 YP_001439969.1 COG: COG3522 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001439970.1 COG: COG3521 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001439971.1 Psort location: extracellular, including cell wall, score: 9 YP_001439972.1 KEGG: btk:BT9727_2623 2.5e-16 acetyltransferase, GNAT family K00680; COG: NOG22518 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001439973.1 multidrug efflux protein involved in adaptation to low energy shock YP_001439974.1 KEGG: rba:RB5256 3.6e-07 cellulase K01179; COG: NOG14136 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001439975.1 Psort location: nuclear, score: 23 YP_001439976.1 COG: NOG09782 non supervised orthologous group; Psort location: vacuolar, score: 9 YP_001439977.1 KEGG: cal:orf19.201 0.00014 CDC47; DNA helicase and DNA replication licensing factor K02210; COG: COG2149 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001439978.1 KEGG: ece:Z5177 7.3e-216 putative 6-phospho-beta-glucosidase K01222; COG: COG1486 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases; Psort location: cytoplasmic, score: 23 YP_001439979.1 KEGG: ece:Z5178 2.1e-234 putative PTS component K02749:K02750; COG: COG1263 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific; Psort location: plasma membrane, score: 23 YP_001439980.1 KEGG: btk:BT9727_3183 9.3e-26 transcriptional regulator, GntR family; COG: COG2188 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001439981.1 16 kDa heat shock protein B; associates with aggregated proteins, together with ibpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; ATP-independent YP_001439982.1 with IbpB associates with aggregated proteins to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress YP_001439983.1 Psort location: mitochondrial, score: 23 YP_001439984.1 COG: COG5645 Predicted periplasmic lipoprotein; Psort location: endoplasmic reticulum, score: 9 YP_001439985.1 KEGG: eci:UTI89_C4240 9.5e-159 yidR; hypothetical protein YidR; COG: NOG06296 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001439986.1 KEGG: ypm:YP_2347 5.8e-72 ldhA2; putative D-isomer specific 2-hydroxyacid dehydrogenase family protein K00050; COG: COG1052 Lactate dehydrogenase and related dehydrogenases; Psort location: endoplasmic reticulum, score: 9 YP_001439987.1 KEGG: bur:Bcep18194_A4604 0.00018 major facilitator superfamily (MFS_1) transporter and phospholipid/glycerol acyltransferase K00655; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001439988.1 KEGG: dre:30298 9.5e-06 jak2b; Janus kinase 2b K04447; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001439989.1 KEGG: stm:STM3828 6.0e-189 dgoA; 2-oxo-3-deoxygalactonate 6-phosphate aldolase/galactonate dehydratase K01631:K01684; COG: COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily; Psort location: cytoplasmic, score: 23 YP_001439990.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-galactonate 6-phosphate; functions in galactonate metabolism YP_001439991.1 KEGG: ssn:SSO_3644 2.0e-110 dgoK; 2-oxo-3-deoxygalactonate kinase K00883; COG: COG3734 2-keto-3-deoxy-galactonokinase; Psort location: cytoplasmic, score: 23 YP_001439992.1 COG: COG2186 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001439993.1 Psort location: mitochondrial, score: 23 YP_001439994.1 YidA; catalyzes the dephosphorylation of erythrose 4-phosphate (preferred substrate), mannose 1-phosphate and p-nitrophenyl phosphate; hydrolyzes the alpha-D-glucose-1-phosphate but not the beta form; member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins YP_001439995.1 negatively supercoils closed circular double-stranded DNA YP_001439996.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA YP_001439997.1 binds the polymerase to DNA and acts as a sliding clamp YP_001439998.1 KEGG: shn:Shewana3_0009 7.3e-184 chromosomal replication initiator protein DnaA K00972; COG: COG0593 ATPase involved in DNA replication initiation; Psort location: cytoplasmic, score: 23 YP_001439999.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates YP_001440000.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria YP_001440001.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_001440002.1 KEGG: pen:PSEEN0425 4.6e-08 glpE; THIosulfate sulfurtransferase (rhodanese) K01010; COG: COG0607 Rhodanese-related sulfurtransferase; Psort location: vesicles of secretory system, score: 9 YP_001440003.1 COG: NOG22885 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001440004.1 COG: COG4392 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001440005.1 COG: COG1296 Predicted branched-chain amino acid permease (azaleucine resistance); Psort location: endoplasmic reticulum, score: 9 YP_001440006.1 KEGG: bcz:BCZK0234 4.6e-08 rimI; ribosomal-protein-alanine N-acetyltransferase K03789; COG: COG0456 Acetyltransferases; Psort location: cytoplasmic, score: 23 YP_001440007.1 COG: COG4340 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001440008.1 COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001440009.1 Psort location: mitochondrial, score: 23 YP_001440010.1 COG: COG2091 Phosphopantetheinyl transferase; Psort location: nuclear, score: 23 YP_001440011.1 KEGG: eci:UTI89_C4266 2.1e-83 yieF; hypothetical protein; COG: COG0431 Predicted flavoprotein; Psort location: cytoplasmic, score: 23 YP_001440012.1 KEGG: bcz:BCZK0244 1.1e-88 guanine-hypoxanTHIne permease; xanTHIne/uracil permease family protein K06901; COG: COG2252 Permeases; Psort location: plasma membrane, score: 23 YP_001440013.1 YieH; catalyzes the dephosphorylation of phosphoenolpyruvate, AMP and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; member of the haloacid dehalogenase-like hydrolases superfamily YP_001440014.1 KEGG: eci:UTI89_C4270 2.7e-138 yieL; putative xylanase K07214; COG: COG2382 Enterochelin esterase and related enzymes; Psort location: extracellular, including cell wall, score: 9 YP_001440015.1 regulates several genes involved in high affinity phosphate uptake; under conditions of high phosphate concentrations downregulates the PHO regulon YP_001440016.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_001440017.1 Part of the ABC transporter complex PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions YP_001440018.1 part of the ATP-dependent phosphate uptake system PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions YP_001440019.1 KEGG: mst:Msp_0343 2.4e-08 pstS; PstS K02040; COG: COG0226 ABC-type phosphate transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001440020.1 Psort location: extracellular, including cell wall, score: 9 YP_001440021.1 Psort location: endoplasmic reticulum, score: 9 YP_001440022.1 Psort location: nuclear, score: 23 YP_001440023.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source YP_001440024.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis YP_001440025.1 Psort location: cytoplasmic, score: 23 YP_001440026.1 Psort location: cytoplasmic, score: 23 YP_001440027.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane YP_001440028.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_001440029.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_001440030.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_001440031.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex YP_001440032.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. YP_001440033.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 YP_001440034.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_001440035.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation YP_001440036.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA YP_001440037.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_001440038.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_001440039.1 transcriptional repressor of asnA which codes for aspartate-ammonia ligase YP_001440040.1 catalyzes the formation of asparagine from aspartate and ammonia YP_001440041.1 contains a von Willibrand factor type A domain; stimulates the ATPase activity of RavA YP_001440042.1 interacts with LdcI, lysine decarboxylase; may be active in late log/ early stationary phase YP_001440043.1 Responsible for the low-affinity transport of potassium into the cell; involved in potassium ion uptake under hyper-osmotic stress at a low pH YP_001440044.1 cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source YP_001440045.1 with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain YP_001440046.1 functions to transport ribose at high affinity; forms a complex with RbsA2C2B YP_001440047.1 periplasmic substrate-binding component of the ATP-dependent ribose transport system YP_001440048.1 catalyzes the formation of D-ribose 5-phosphate from ribose YP_001440049.1 DNA-binding transcriptional repressor of ribose metabolism YP_001440050.1 KEGG: sgl:SG1466 3.6e-08 dethiobiotinsynthase K01935; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001440051.1 KEGG: reh:H16_A3019 0.00028 hutC; histidine utilization repressor; COG: COG2186 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001440052.1 in Escherichia coli the MobB protein is not essential but has been found to interact with multiple proteins involved in the molybdopterin guanine dinucleotide cofactor biosynthesis pathway YP_001440053.1 in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis YP_001440054.1 COG: COG3084 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001440055.1 catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages YP_001440056.1 KEGG: bci:BCI_0257 9.4e-49 dsbA; THIol:disulfide interchange protein DsbA K01829; COG: COG0526 Thiol-disulfide isomerase and THIoredoxins; Psort location: extracellular, including cell wall, score: 9 YP_001440057.1 KEGG: eci:UTI89_C4450 1.9e-137 yihG; hypothetical protein YihG K00655; COG: COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase; Psort location: mitochondrial, score: 23 YP_001440058.1 Psort location: nuclear, score: 23 YP_001440059.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair YP_001440060.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential YP_001440061.1 KEGG: bld:BLi03964 0.0033 rpoE; RNA polymerase (delta subunit); RBL01619 K03048; COG: COG3078 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001440062.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_001440063.1 response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes; interacts with sigma-54 YP_001440064.1 sensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation YP_001440065.1 forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme YP_001440066.1 KEGG: eci:UTI89_C4460 0. typA, bipA, yihK, yjhK; putative GTP-binding factor K06207; COG: COG1217 Predicted membrane GTPase involved in stress response; Psort location: cytoplasmic, score: 23 YP_001440067.1 porin involved in the transport of small molecular weight solutes (up to 600 Daltons) across the cell wall; specific substrate still unknown YP_001440068.1 KEGG: eci:UTI89_C4210 3.8e-45 yicJ; hypothetical symporter YicJ K03292; COG: COG2211 Na+/melibiose symporter and related transporters; Psort location: plasma membrane, score: 23 YP_001440069.1 KEGG: eci:UTI89_C4210 8.7e-46 yicJ; hypothetical symporter YicJ K03292; COG: COG2211 Na+/melibiose symporter and related transporters; Psort location: endoplasmic reticulum, score: 9 YP_001440070.1 COG: COG0730 Predicted permeases; Psort location: plasma membrane, score: 23 YP_001440071.1 KEGG: lic:LIC11117 2.7e-129 malZ; alpha-glucosidase K01187; COG: COG1501 Alpha-glucosidases, family 31 of glycosyl hydrolases; Psort location: cytoplasmic, score: 23 YP_001440072.1 KEGG: eco:b3879 2.8e-79 yihR; predicted aldose-1-epimerase K01785; COG: COG2017 Galactose mutarotase and related enzymes; Psort location: cytoplasmic, score: 23 YP_001440073.1 KEGG: eco:b3880 2.3e-205 yihS; predicted glucosamine isomerase; COG: COG2942 N-acyl-D-glucosamine 2-epimerase; Psort location: cytoplasmic, score: 23 YP_001440074.1 KEGG: eco:b3881 1.7e-120 yihT; predicted aldolase; COG: COG3684 Tagatose-1,6-bisphosphate aldolase; Psort location: cytoplasmic, score: 23 YP_001440075.1 KEGG: ece:Z5420 1.4e-123 yihU; putative dehydrogenase K08318; COG: COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001440076.1 KEGG: eci:UTI89_C4462 3.4e-99 yihV; hypothetical sugar kinase YihV K00846; COG: COG0524 Sugar kinases, ribokinase family; Psort location: cytoplasmic, score: 23 YP_001440077.1 COG: COG1349 Transcriptional regulators of sugar metabolism; Psort location: extracellular, including cell wall, score: 9 YP_001440078.1 KEGG: xtr:448759 4.4e-11 ephx2; epoxide hydrolase 2, cytoplasmic K08726; COG: COG1011 Predicted hydrolase (HAD superfamily); Psort location: cytoplasmic, score: 23 YP_001440079.1 RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease YP_001440080.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine YP_001440081.1 KEGG: eci:UTI89_C4472 5.7e-161 yiiD; putative acetyltransferase K00633; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: cytoplasmic, score: 23 YP_001440082.1 COG: NOG06061 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001440083.1 KEGG: hpa:HPAG1_1114 0.00065 hypothetical protein K00760; COG: COG2233 XanTHIne/uracil permeases; Psort location: plasma membrane, score: 23 YP_001440084.1 Psort location: extracellular, including cell wall, score: 9 YP_001440085.1 Psort location: extracellular, including cell wall, score: 9 YP_001440086.1 KEGG: ava:Ava_4160 0.0044 VCBS K01317; Psort location: extracellular, including cell wall, score: 9 YP_001440087.1 COG: NOG06200 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001440088.1 COG: COG3188 P pilus assembly protein, porin PapC; Psort location: extracellular, including cell wall, score: 9 YP_001440089.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: cytoplasmic, score: 23 YP_001440090.1 Psort location: endoplasmic reticulum, score: 9 YP_001440091.1 catalyzes branch migration in Holliday junction intermediates YP_001440092.1 specifically modifies tRNA at position G18 YP_001440093.1 KEGG: spt:SPA3594 0. spoT; Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase; CG Site No. 156 K01139; COG: COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases; Psort location: cytoplasmic, score: 23 YP_001440094.1 promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits YP_001440095.1 Essential for recycling GMP and indirectly, cGMP YP_001440096.1 this ligase is similar to LigA but it lacks the C-terminal BRCT domain; catalyzes strand joining of nicked DNA in the presence of a divalent cation and NAD+ YP_001440097.1 COG: COG2860 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001440098.1 Psort location: cytoplasmic, score: 23 YP_001440099.1 Psort location: nuclear, score: 23 YP_001440100.1 KEGG: pac:PPA1226 0.0037 UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790; COG: COG1396 Predicted transcriptional regulators; Psort location: nuclear, score: 23 YP_001440101.1 Psort location: nuclear, score: 23 YP_001440102.1 Psort location: cytoskeletal, score: 9 YP_001440103.1 Psort location: nuclear, score: 23 YP_001440104.1 COG: COG0582 Integrase; Psort location: cytoplasmic, score: 23 YP_001440105.1 COG: COG1561 Uncharacterized stress-induced protein; Psort location: cytoplasmic, score: 23 YP_001440106.1 KEGG: sty:STY4060 1.6e-101 rph; RNase PH K00989; COG: COG0689 RNase PH; Psort location: cytoplasmic, score: 23 YP_001440107.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_001440108.1 FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly YP_001440109.1 catalyzes the formation of dUMP from dUTP YP_001440110.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine YP_001440111.1 COG: COG2003 DNA repair proteins; Psort location: cytoplasmic, score: 23 YP_001440112.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_001440113.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases YP_001440114.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_001440115.1 KEGG: sgl:SG2204 2.6e-92 lipopolysaccharide glycosyltransferase; COG: COG0463 Glycosyltransferases involved in cell wall biogenesis; Psort location: mitochondrial, score: 23 YP_001440116.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A YP_001440117.1 KEGG: hwa:HQ3540A 1.1e-05 aslA; probable arylsulfatase K01130; COG: COG2194 Predicted membrane-associated, metal-dependent hydrolase; Psort location: endoplasmic reticulum, score: 9 YP_001440118.1 Psort location: cytoplasmic, score: 23 YP_001440119.1 KEGG: plu:plu4290 1.0e-122 unnamed protein product; similar to glycosyltransferase; COG: COG0463 Glycosyltransferases involved in cell wall biogenesis; Psort location: cytoplasmic, score: 23 YP_001440120.1 Psort location: plasma membrane, score: 23 YP_001440121.1 KEGG: azo:azo2322 9.7e-31 glycosyltransferase; COG: COG0438 Glycosyltransferase; Psort location: cytoplasmic, score: 23 YP_001440122.1 KEGG: ava:Ava_1122 6.3e-27 glycosyl transferase, group 1 K00703; COG: COG0438 Glycosyltransferase; Psort location: cytoplasmic, score: 23 YP_001440123.1 KEGG: dar:Daro_0152 3.0e-91 lipopolysaccharide heptosyltransferase III, putative K02849; COG: COG0859 ADP-heptose:LPS heptosyltransferase; Psort location: cytoplasmic, score: 23 YP_001440124.1 KEGG: ece:Z5048 2.3e-141 rfaC; heptosyl transferase I; lipopolysaccharide core biosynthesis K02841; COG: COG0859 ADP-heptose:LPS heptosyltransferase; Psort location: cytoplasmic, score: 23 YP_001440125.1 catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core YP_001440126.1 catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose YP_001440127.1 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine YP_001440128.1 converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism YP_001440129.1 KEGG: dar:Daro_3929 2.4e-27 glycosyl transferase, family 2; COG: COG0463 Glycosyltransferases involved in cell wall biogenesis; Psort location: extracellular, including cell wall, score: 9 YP_001440130.1 COG: COG2861 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001440131.1 KEGG: cya:CYA_1627 3.4e-28 peptidase, M23B family; COG: COG4942 Membrane-bound metallopeptidase; Psort location: extracellular, including cell wall, score: 9 YP_001440132.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate YP_001440133.1 KEGG: pha:PSHAa0367 1.0e-26 rhodanese sulfur transferase K01010; COG: COG0607 Rhodanese-related sulfurtransferase; Psort location: cytoplasmic, score: 23 YP_001440134.1 KEGG: eci:UTI89_C4152 1.7e-35 grxC; glutaredoxin 3 K03676; COG: COG0695 Glutaredoxin and related proteins; Psort location: cytoplasmic, score: 23 YP_001440135.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA YP_001440136.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_001440137.1 catalyzes the O-acetylation of serine YP_001440138.1 member of the SPOUT superfamily of RNA methyltransferases; no methyltransferase activity observed with certain tRNA substrates YP_001440139.1 part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors YP_001440140.1 response regulator in two-component regulatory system with CpxA; part of the envelope stress response system YP_001440141.1 repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates YP_001440142.1 Psort location: extracellular, including cell wall, score: 9 YP_001440143.1 member of cation diffusion facilitator family; CDF; membrane-bound; induced by both zinc and iron, but does not induce resistance to zinc; can transport zinc(II) in a proton-dependent manner; instead this protein induces iron resistance; forms dimers YP_001440144.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis YP_001440145.1 COG: COG1613 ABC-type sulfate transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001440146.1 KEGG: spt:SPA3907 5.6e-83 cdh; CDP-diglyceride hydrolase K01521; COG: COG2134 CDP-diacylglycerol pyrophosphatase; Psort location: extracellular, including cell wall, score: 9 YP_001440147.1 COG: COG0471 Di- and tricarboxylate transporters; Psort location: plasma membrane, score: 23 YP_001440148.1 Psort location: cytoplasmic, score: 23 YP_001440149.1 KEGG: gbe:GbCGDNIH1_1243 4.1e-16 urate oxidase K00365; COG: COG2351 Transthyretin-like protein; Psort location: extracellular, including cell wall, score: 9 YP_001440150.1 Psort location: nuclear, score: 23 YP_001440151.1 induced by CusR in the presence of copper; YedW induces the expression of the upstream gene yedV (encoding a sensor kinase) as well as yedW; yedVW is one of four copper regulons found in E. coli; part of the copper homeostasis mechanism; confers resistance to copper and several drugs when induced YP_001440152.1 KEGG: sty:STY1127 8.5e-119 copS; histidine kinase K07644; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 9 YP_001440153.1 COG: COG1266 Predicted metal-dependent membrane protease; Psort location: endoplasmic reticulum, score: 9 YP_001440154.1 KEGG: azo:azo0951 0.00024 conserved hypothetical phosphomannose protein K01809; COG: COG1917 Uncharacterized conserved protein, contains double-stranded beta-helix domain; Psort location: cytoplasmic, score: 23 YP_001440155.1 KEGG: eci:UTI89_C1599 1.5e-41 hypothetical protein YcjY; COG: COG1073 Hydrolases of the alpha/beta superfamily; Psort location: extracellular, including cell wall, score: 9 YP_001440156.1 KEGG: eci:UTI89_C0359 1.3e-163 yahK; hypothetical zinc-type alcohol dehydrogenase-like protein YahK K00001; COG: COG1064 Zn-dependent alcohol dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001440157.1 KEGG: tfu:Tfu_2783 0.0010 thymidylate kinase K00943; COG: COG2814 Arabinose efflux permease; Psort location: plasma membrane, score: 23 YP_001440158.1 KEGG: shn:Shewana3_3435 8.4e-08 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001440159.1 KEGG: sat:SYN_02803 4.2e-25 glycosyltransferase K00754; COG: COG0463 Glycosyltransferases involved in cell wall biogenesis; Psort location: cytoplasmic, score: 23 YP_001440160.1 Psort location: cytoplasmic, score: 23 YP_001440161.1 KEGG: ava:Ava_C0128 5.7e-58 ferredoxin K00190; COG: COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs; Psort location: cytoplasmic, score: 23 YP_001440162.1 KEGG: eco:b0285 1.0e-136 yagS; putative oxidoreductase, FAD-binding domain K00087; COG: COG1319 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs; Psort location: cytoplasmic, score: 23 YP_001440163.1 KEGG: ecj:JW0278 0. yagR; predicted oxidoreductase with molybdenum-binding domain K00087; COG: COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs; Psort location: cytoplasmic, score: 23 YP_001440164.1 KEGG: aci:ACIAD2466 0.00022 putative xanTHIne dehydrogenase protein; putative xanTHIne dehydrogenase accessory factor (XdhC) K00087; COG: COG1975 XanTHIne and CO dehydrogenases maturation factor, XdhC/CoxF family; Psort location: cytoplasmic, score: 23 YP_001440165.1 KEGG: hma:pNG7236 5.4e-14 glmU; UDP-N-acetylglucosamine pyrophosphorylase K00972; COG: COG2068 Uncharacterized MobA-related protein; Psort location: cytoplasmic, score: 23 YP_001440166.1 KEGG: ret:RHE_PC00204 3.0e-107 probable oxidoreductase protein, aldo-keto aldolase family; COG: COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001440167.1 COG: NOG18230 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001440168.1 KEGG: eci:UTI89_C0121 1.5e-05 usp; uropathogenic specific protein K01150; COG: COG3157 Hemolysin-coregulated protein (uncharacterized); Psort location: cytoplasmic, score: 23 YP_001440169.1 Psort location: endoplasmic reticulum, score: 9 YP_001440170.1 may be involved in the transport of galactosides-pentoses-hexuronides YP_001440171.1 catalyzes the transfer of alpha-xylosyl residue from alpha-xyloside to xylose, glucose, mannose, fructose, maltose, isomaltose, nigerose, kojibiose, sucrose, and trehalose; shows higher activity against alpha-xylosyl fluoride, isoprimeverose (6-O-alpha-xylopyranosyl-glucopyranose), and alpha-xyloside in xyloglucan oligosaccharides YP_001440172.1 transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis YP_001440173.1 periplasmic enzyme that degrades maltodextrins that enter via the outer membrane porin LamB; hydrolyzes alpha-(1,4) glycosidic linkages; contains internal disulfide bonds YP_001440174.1 COG: COG2992 Uncharacterized FlgJ-related protein; Psort location: nuclear, score: 23 YP_001440175.1 KEGG: bcz:BCZK2914 1.3e-10 adaA; methylphosphotriester-DNA alkyltransferase K00567; COG: COG1609 Transcriptional regulators; Psort location: cytoskeletal, score: 9 YP_001440176.1 KEGG: msm:MSMEG_1706 1.2e-66 xylose transport system permease protein XylH; COG: COG4214 ABC-type xylose transport system, permease component; Psort location: plasma membrane, score: 23 YP_001440177.1 with XylFH is part of the high affinity xylose ABC transporter YP_001440178.1 periplasmic substrate-binding component of the ATP-dependent xylose transport system; high affinity YP_001440179.1 catalyzes the interconversion of D-xylose to D-xylulose YP_001440180.1 KEGG: eci:UTI89_C4105 1.1e-212 xylB; xylulose kinase K00854; COG: COG1070 Sugar (pentulose and hexulose) kinases; Psort location: cytoplasmic, score: 23 YP_001440181.1 KEGG: ret:RHE_PF00312 1.2e-39 probable isochorismatase protein K05993; COG: COG1335 Amidases related to nicotinamidase; Psort location: mitochondrial, score: 23 YP_001440182.1 KEGG: bpm:BURPS1710b_A2214 7.2e-19 ftrA; transcriptional activator FtrA K00356; COG: COG4977 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain; Psort location: endoplasmic reticulum, score: 9 YP_001440183.1 KEGG: bba:Bd3365 0.0094 lspA; signal peptidase II K03101; COG: COG3274 Uncharacterized protein conserved in bacteria; Psort location: plasma membrane, score: 23 YP_001440184.1 COG: NOG10996 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001440185.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_001440186.1 Psort location: cytoplasmic, score: 23 YP_001440187.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_001440188.1 KEGG: mma:MM1160 0.0050 nucleotidyltransferase; COG: COG2944 Predicted transcriptional regulator; Psort location: nuclear, score: 23 YP_001440189.1 Psort location: cytoplasmic, score: 23 YP_001440190.1 Psort location: cytoplasmic, score: 23 YP_001440191.1 COG: NOG06217 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001440192.1 KEGG: ece:Z4978 1.9e-144 yiaE; putative dehydrogenase K00090; COG: COG1052 Lactate dehydrogenase and related dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001440193.1 KEGG: pca:Pcar_2776 0.0015 2-acyl-glycerophospho-ethanolamine acyltransferase K05939:K01909; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001440194.1 KEGG: bur:Bcep18194_A5029 6.7e-103 sugar kinase, ribokinase family K00874; COG: COG0524 Sugar kinases, ribokinase family; Psort location: cytoplasmic, score: 23 YP_001440195.1 COG: NOG13334 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001440196.1 KEGG: efa:EF1922 0.0018 transcriptional regulator, LacI family/carbohydrate kinase, PfkB family protein K00852; COG: COG1609 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001440197.1 COG: COG3443 Predicted periplasmic or secreted protein; Psort location: extracellular, including cell wall, score: 9 YP_001440198.1 KEGG: bxe:Bxe_A4171 4.6e-05 putative cytochrome c oxidase K00403; COG: COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins; Psort location: extracellular, including cell wall, score: 9 YP_001440199.1 KEGG: sfx:S4184 0. bisC; biotin sulfoxide reductase K08351; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: cytoplasmic, score: 23 YP_001440200.1 KEGG: sec:SC3575 7.6e-47 yiaC; putative acetyltransferase K03826; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: extracellular, including cell wall, score: 9 YP_001440201.1 KEGG: ecc:c4367 5.1e-73 tag; DNA-3-methyladenine glycosylase I K01246; COG: COG2818 3-methyladenine DNA glycosylase; Psort location: cytoskeletal, score: 9 YP_001440202.1 COG: COG5571 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion; Psort location: cytoplasmic, score: 23 YP_001440203.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001440204.1 KEGG: reh:H16_A1791 6.2e-29 predicted redox protein, regulator of disulfide bond formation K01768; COG: COG1764 Predicted redox protein, regulator of disulfide bond formation; Psort location: cytoplasmic, score: 23 YP_001440205.1 catalyzes the addition of a phosphoethanolamine group to the outer Kdo residue of lipopolysaccharide YP_001440207.1 Psort location: extracellular, including cell wall, score: 9 YP_001440208.1 COG: NOG35673 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001440209.1 KEGG: shn:Shewana3_2650 1.2e-121 acetate kinase K00925; COG: COG0747 ABC-type dipeptide transport system, periplasmic component; Psort location: cytoplasmic, score: 23 YP_001440210.1 transports peptides consisting of two or three amino acids YP_001440211.1 KEGG: bpm:BURPS1710b_A0449 1.9e-05 glycine betaine/L-proline ABC transporter, permease protein K02001; COG: COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001440212.1 DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF YP_001440213.1 Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides YP_001440214.1 Psort location: mitochondrial, score: 23 YP_001440215.1 COG: NOG05994 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001440216.1 COG: NOG15366 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001440217.1 KEGG: vfi:VFA0886 1.5e-23 zinc metalloprotease; COG: NOG14695 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001440218.1 COG: NOG13865 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001440219.1 KEGG: ava:Ava_4268 0.00020 anion-transporting ATPase K01551; COG: COG1192 ATPases involved in chromosome partitioning; Psort location: cytoplasmic, score: 23 YP_001440220.1 polymerizes uridine 5'-diphosphate glucose to cellulose; acts with BcsB, BcsZ and BcsC in cellulose biosynthesis YP_001440221.1 binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP) YP_001440222.1 catalyzes the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans YP_001440223.1 cellulose is produced by the multicellular morphotypes of E. coli and Salmonella typhimurium; the cellulose biosynthesis genes bcsA, bcsB, bcsZ and bcsC are constitutively transcribed, however, cellulose synthesis is dependent on the expression of adrA YP_001440224.1 HmsP in Yersinia pestis plays a role in invasion of epithelial cells; the EAL-domain portion of HmsP from Y. pestis shows phosphodiesterase activity which is required for the inhibition of biofilm formation; inner membrane protein; similar to a putative phosphodiesterase protein from E. coli YP_001440225.1 involved in the transport of C4-dicarboxylates across the membrane YP_001440226.1 KEGG: eci:UTI89_C4059 1.5e-206 yhjJ; protein YhjJ precursor K01412; COG: COG0612 Predicted Zn-dependent peptidases; Psort location: extracellular, including cell wall, score: 9 YP_001440227.1 KEGG: ecs:ECs4406 3.9e-137 ketodeoxygluconokinase K00874; COG: COG0524 Sugar kinases, ribokinase family; Psort location: cytoplasmic, score: 23 YP_001440228.1 in Escherichia coli this protein is involved in flagellar function YP_001440229.1 COG: COG2982 Uncharacterized protein involved in outer membrane biogenesis; Psort location: endoplasmic reticulum, score: 9 YP_001440230.1 KEGG: cal:orf19.2425 5.8e-05 highly conserved hypothetical protein K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001440231.1 KEGG: eci:UTI89_C4054 6.6e-135 yhjD; hypothetical protein; COG: COG1295 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001440232.1 KEGG: shn:Shewana3_3435 1.1e-10 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001440233.1 KEGG: pen:PSEEN1303 5.4e-85 oxidoreductase, short-chain alcohol dehydrogenase/reductase family; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001440234.1 COG: COG3111 Uncharacterized conserved protein; Psort location: extracellular, including cell wall, score: 9 YP_001440235.1 KEGG: eca:ECA3191 1.5e-18 putative acetyltransferase K00676; COG: COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins; Psort location: cytoplasmic, score: 23 YP_001440236.1 Psort location: cytoplasmic, score: 23 YP_001440237.1 COG: NOG26124 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001440238.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense YP_001440239.1 COG: COG2961 Protein involved in catabolism of external DNA; Psort location: cytoplasmic, score: 23 YP_001440240.1 KEGG: eci:UTI89_C4017 0. prlC, opdA; oligopeptidase A K01414; COG: COG0339 Zn-dependent oligopeptidases; Psort location: cytoplasmic, score: 23 YP_001440241.1 predicted SAM-dependent methyltransferase YP_001440242.1 COG: COG0589 Universal stress protein UspA and related nucleotide-binding proteins; Psort location: cytoplasmic, score: 23 YP_001440243.1 ppGpp-dependent, membrane associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress YP_001440244.1 COG: COG0306 Phosphate/sulphate permeases; Psort location: plasma membrane, score: 23 YP_001440245.1 KEGG: ape:APE_2421 0.00031 electoron transfer flavoprotein-quinone oxidoreductase K00313; COG: COG2081 Predicted flavoproteins; Psort location: cytoplasmic, score: 23 YP_001440246.1 Psort location: cytoplasmic, score: 23 YP_001440247.1 Psort location: cytoplasmic, score: 23 YP_001440248.1 Psort location: cytoplasmic, score: 23 YP_001440249.1 COG: COG2801 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001440250.1 COG: NOG19979 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001440251.1 COG: COG3544 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001440252.1 COG: NOG30724 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001440253.1 KEGG: ecs:ECs0608 2.7e-138 putative 2-component sensor protein K07644; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 23 YP_001440254.1 response regulator in two-component regulatory system with CusS; regulates the copper efflux system YP_001440255.1 with CusA, CusB and CusF is part of a cation efflux system that mediates resistance to copper and silver YP_001440256.1 COG: COG5569 Uncharacterized conserved protein; Psort location: extracellular, including cell wall, score: 9 YP_001440257.1 with CusA, CusC and CusF is part of a cation efflux system that mediates resistance to copper and silver YP_001440258.1 KEGG: eci:UTI89_C2351 6.7e-58 yegO; hypothetical protein YegO K07789; COG: COG3696 Putative silver efflux pump; Psort location: endoplasmic reticulum, score: 9 YP_001440259.1 COG: COG3019 Predicted metal-binding protein; Psort location: extracellular, including cell wall, score: 9 YP_001440260.1 Psort location: extracellular, including cell wall, score: 9 YP_001440261.1 KEGG: sme:SMa1087 9.4e-239 putative cation transport P-type ATPase; COG: COG2217 Cation transport ATPase; Psort location: plasma membrane, score: 23 YP_001440262.1 COG: NOG16192 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001440263.1 KEGG: ece:Z2908 1.1e-18 yebA; hypothetical protein; COG: COG0739 Membrane proteins related to metalloendopeptidases; Psort location: cytoplasmic, score: 23 YP_001440264.1 COG: NOG30724 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001440265.1 KEGG: gbe:GbCGDNIH1_2030 6.8e-149 multicopper oxidase PcoA; COG: COG2132 Putative multicopper oxidases; Psort location: mitochondrial, score: 23 YP_001440266.1 COG: COG3667 Uncharacterized protein involved in copper resistance; Psort location: extracellular, including cell wall, score: 9 YP_001440267.1 COG: COG2372 Uncharacterized protein, homolog of Cu resistance protein CopC; Psort location: endoplasmic reticulum, score: 9 YP_001440268.1 COG: COG1276 Putative copper export protein; Psort location: plasma membrane, score: 23 YP_001440269.1 KEGG: rha:RHA1_ro05622 1.9e-41 response regulator (protein-glutamate methylesterase) K07669; COG: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; Psort location: cytoplasmic, score: 23 YP_001440270.1 KEGG: dar:Daro_2258 5.6e-83 heavy metal sensor kinase K07644; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 9 YP_001440271.1 COG: NOG30724 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001440272.1 KEGG: ece:Z2491 3.7e-93 putative glutamine synthetase K01915; COG: COG0174 Glutamine synthetase; Psort location: cytoplasmic, score: 23 YP_001440273.1 KEGG: eci:UTI89_C1901 1.7e-24 nlpC; probable lipoprotein NlpC precursor; COG: COG0791 Cell wall-associated hydrolases (invasion-associated proteins); Psort location: extracellular, including cell wall, score: 9 YP_001440274.1 KEGG: tbd:Tbd_2668 1.0e-11 phosphoribosylaminoimidazole-succinocarboxamide (SAICAR) synthetase K01923; COG: COG0628 Predicted permease; Psort location: endoplasmic reticulum, score: 9 YP_001440275.1 KEGG: sgl:SG1589 1.0e-05 NADH dehydrogenase I subunit N K00343; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001440276.1 COG: NOG07879 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001440277.1 COG: COG1738 Uncharacterized conserved protein; Psort location: endoplasmic reticulum, score: 9 YP_001440278.1 Psort location: nuclear, score: 23 YP_001440279.1 TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs YP_001440280.1 COG: COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001440281.1 COG: COG3090 TRAP-type C4-dicarboxylate transport system, small permease component; Psort location: endoplasmic reticulum, score: 9 YP_001440282.1 COG: COG1593 TRAP-type C4-dicarboxylate transport system, large permease component; Psort location: plasma membrane, score: 23 YP_001440283.1 P-type ATPase involved in the export of lead, cadmium, zinc and mercury YP_001440284.1 KEGG: bpm:BURPS1710b_A0954 0.00041 DJ-1/PfpI family protein; Psort location: nuclear, score: 23 YP_001440285.1 COG: COG3714 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001440286.1 COG: NOG09778 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001440287.1 COG: COG3776 Predicted membrane protein; Psort location: cytoplasmic, score: 23 YP_001440288.1 catalyzes the methylation of 16S rRNA at position G966 YP_001440289.1 signal recognition protein receptor; functions in the targeting and insertion of membrane proteins YP_001440290.1 putative ATP-binding protein of an ATP-binding cassette transporter; when bound to FtsX, FtsEX localizes to the cell division site and plays a role in the assembly or stability of the septal ring under low-salt growth conditions YP_001440291.1 putative ABC transporter, membrane protein YP_001440292.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters YP_001440293.1 KEGG: reh:H16_B0980 1.2e-151 transcriptional regulator, MocR family; COG: COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs; Psort location: cytoplasmic, score: 23 YP_001440294.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate YP_001440295.1 COG: COG1226 Kef-type K+ transport systems, predicted NAD-binding component; Psort location: cytoplasmic, score: 23 YP_001440296.1 KEGG: tde:TDE2249 0.00048 mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase K01000; COG: COG0814 Amino acid permeases; Psort location: plasma membrane, score: 23 YP_001440297.1 KEGG: ava:Ava_2791 0.0016 serine/threonine protein kinase K00903; COG: COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component; Psort location: endoplasmic reticulum, score: 9 YP_001440298.1 COG: NOG09777 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001440299.1 Psort location: extracellular, including cell wall, score: 9 YP_001440300.1 LivHMGF is the membrane component of the LIV-I/LS branched-chain amino acid transporter YP_001440301.1 Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine YP_001440302.1 Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine YP_001440303.1 with LivGHMJ and LivGHMK is part of the high-affinity branched-chain amino acid transport system; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine YP_001440304.1 COG: COG2161 Antitoxin of toxin-antitoxin stability system; Psort location: cytoplasmic, score: 23 YP_001440305.1 COG: COG3654 Prophage maintenance system killer protein; Psort location: cytoplasmic, score: 23 YP_001440306.1 with UgpACE is involved in the uptake of glycerol-3-phosphate YP_001440307.1 with UgpEC is involved in the uptake of glycerol-3-phosphate YP_001440308.1 with UgpABC is involved in uptake of glycerol-3-phosphate YP_001440309.1 part of the UgpABCE glycerol-3-phosphate uptake system YP_001440310.1 hydrolyzes diesters during transport at the inner face of the cytoplasmic membrane to glycerol-3-phosphate and alcohol; induced when cells are starved for inorganic phosphate YP_001440311.1 KEGG: ddi:DDB0229429 4.4e-07 putative CMGC family protein kinase K08825; COG: NOG08680 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001440312.1 periplasmic enzyme; post-translationally processed into two subunits which are required for wild-type enzyme activity; cleaves the gammaglutamyl linkages of compounds such as glutathione and transfer the gammaglutamyl group to other amino acids and peptides YP_001440313.1 KEGG: ecs:ECs4290 8.7e-62 putative acetyltransferase K03825; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: cytoplasmic, score: 23 YP_001440314.1 KEGG: ecp:ECP_3535 1.9e-160 putative oxidoreductase YhhX; COG: COG0673 Predicted dehydrogenases and related proteins; Psort location: mitochondrial, score: 23 YP_001440315.1 KEGG: shn:Shewana3_3385 3.8e-14 hypoxanTHIne phosphoribosyltransferase K00760; COG: COG1741 Pirin-related protein; Psort location: cytoplasmic, score: 23 YP_001440316.1 KEGG: efa:EF1922 1.1e-06 transcriptional regulator, LacI family/carbohydrate kinase, PfkB family protein K00852; COG: COG1609 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001440317.1 Psort location: cytoplasmic, score: 23 YP_001440318.1 thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate YP_001440319.1 KEGG: eci:UTI89_C3106 1.7e-65 ygbN; hypothetical permease YgbN K03299; COG: COG2610 H+/gluconate symporter and related permeases; Psort location: plasma membrane, score: 23 YP_001440320.1 COG: COG2184 Protein involved in cell division; Psort location: cytoplasmic, score: 23 YP_001440321.1 Psort location: cytoplasmic, score: 23 YP_001440322.1 YhgN; Ec0197; hydrolyzes nucleoside triphosphates with an O6 atom-containing purine base to nucleoside monophosphate and pyrophosphate; seems to play a role in the elimination of aberrant purine-derived nucleotides containing the 6-keto group; shows preference for deoxyinosine triphosphate and xanthosine triphosphate over standard nucleoside triphosphates (dATP, dCTP, dGTP, and dTTP) YP_001440323.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde YP_001440324.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain YP_001440325.1 catalyzes the hydrolysis of the alpha-1,6-glucosidic linkages in partially depolymerized glycogen YP_001440326.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate YP_001440327.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose YP_001440328.1 KEGG: spt:SPA3385 0. glgP; glycogen phosphorylase K00688; COG: COG0058 Glucan phosphorylase; Psort location: cytoplasmic, score: 23 YP_001440329.1 Psort location: endoplasmic reticulum, score: 9 YP_001440330.1 KEGG: ava:Ava_3170 5.0e-34 putative diguanylate cyclase (GGDEF domain) K02488; COG: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; Psort location: endoplasmic reticulum, score: 9 YP_001440331.1 in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane YP_001440332.1 belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine YP_001440333.1 protease responsible for the cleavage between Ser and Asp residues of proteins in regions of high local hydrophilicity YP_001440334.1 represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism YP_001440335.1 Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides YP_001440336.1 KEGG: sec:SC3446 0. malP; maltodextrin phosphorylase K00688; COG: COG0058 Glucan phosphorylase; Psort location: cytoplasmic, score: 23 YP_001440337.1 amylomaltase; acts to release glucose from maltodextrins YP_001440338.1 COG: COG1278 Cold shock proteins; Psort location: cytoplasmic, score: 23 YP_001440339.1 cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source YP_001440340.1 KEGG: reh:H16_A0339 2.9e-22 predicted amidophosphoribosyltransferase; COG: COG1040 Predicted amidophosphoribosyltransferases; Psort location: endoplasmic reticulum, score: 9 YP_001440341.1 KEGG: eci:UTI89_C3913 1.6e-99 bioH; carboxylesterase involved in biosynthesis of pimeloyl-CoA/carboxylesterase K02170; COG: COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily); Psort location: cytoplasmic, score: 23 YP_001440342.1 COG: NOG30300 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001440343.1 COG: NOG13904 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001440344.1 cytoplasmic membrane ferrous uptake system permease; mutations disrupt the ability of Escherichia coli to take up ferrous iron; GTP-binding protein which requires GTP for efficient iron(II) uptake YP_001440345.1 COG: COG1918 Fe2+ transport system protein A; Psort location: cytoplasmic, score: 23 YP_001440346.1 Psort location: mitochondrial, score: 23 YP_001440347.1 KEGG: bur:Bcep18194_A5099 1.1e-246 RNA binding S1; COG: COG2183 Transcriptional accessory protein; Psort location: cytoplasmic, score: 23 YP_001440348.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_001440349.1 part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation YP_001440350.1 membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR YP_001440351.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP YP_001440352.1 Psort location: mitochondrial, score: 23 YP_001440353.1 Psort location: nuclear, score: 23 YP_001440354.1 COG: NOG06297 non supervised orthologous group; Psort location: plasma membrane, score: 23 YP_001440355.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers YP_001440356.1 COG: COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog); Psort location: nuclear, score: 23 YP_001440357.1 KEGG: bur:Bcep18194_A3622 0.00015 2-phosphoglycolate phosphatase K01091; COG: COG1011 Predicted hydrolase (HAD superfamily); Psort location: cytoplasmic, score: 23 YP_001440358.1 COG: NOG06324 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001440359.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose YP_001440360.1 bifunctional murein transglycosylase/murein transpeptidase; penicillin-binding protein 1A; involved in the synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation; penicillin-insensitive transglycosylase catalyzes the formation of linear glycan strands and the penicillin-sensitive transpeptidase catalyzes the cross-linking of the peptide subunits YP_001440361.1 COG: NOG05966 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001440362.1 COG: COG3166 Tfp pilus assembly protein PilN; Psort location: mitochondrial, score: 23 YP_001440363.1 COG: NOG13913 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001440364.1 COG: NOG12171 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001440365.1 outer membrane porin probably involved in uptake of extracellular double-stranded DNA; similar to outer membrane competence protein ComE from Haemophilus influenzae and outer membrane protein PilQ involved in type IV pilus production from Pseudomonas aeruginosa YP_001440366.1 type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis YP_001440367.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis YP_001440368.1 Psort location: mitochondrial, score: 23 YP_001440369.1 KEGG: cal:orf19.575 1.3e-08 HYR5; similar to HYR1 K01186; COG: COG3266 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001440370.1 KEGG: eco:b3387 2.0e-119 dam; DNA adenine methylase K06223; COG: COG0338 Site-specific DNA methylase; Psort location: cytoplasmic, score: 23 YP_001440371.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate YP_001440372.1 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate YP_001440373.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001440374.1 Psort location: mitochondrial, score: 23 YP_001440375.1 COG: NOG13903 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001440376.1 may act as a transcriptional regulator of a putative fructoselysine-induced operon containing the yhfM, yhfN, yhfO, yhfP, yhfQ, and yhfR genes YP_001440377.1 KEGG: eco:b3374 1.1e-102 frlD, yhfQ; fructoselysine 6-kinase K00924; COG: COG0524 Sugar kinases, ribokinase family; Psort location: cytoplasmic, score: 23 YP_001440378.1 YhfOP; YhfP; YhfO; FrlC; catalyzes the interconversion of fructoselysine and psicoselysine YP_001440379.1 catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine YP_001440380.1 inner membrane protein possibly involved in fructoselysine transport; member of the flr operon YP_001440381.1 multifunction enzyme consisting of uroporphyrin-III C-methyltransferase, precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase; catalyzes the methylation of uroporphyrinogen III to form precorrin-2, then catalyzes formation of sirohydrochlorin from precorrin-2 and finally catalyzed the formation of siroheme from sirohydrochlorin YP_001440382.1 involved in reducing nitrite to ammonium to detoxify nitrite accumulation in anaerobic nitrate-respiring cells and regenerate NAD+; bounds to NirB, the cytoplasmic subunit, whose expression is induced at high nitrate concentrations YP_001440383.1 KEGG: stm:STM3474 0. nirB; nitrite reductase, large subunit K00362; COG: COG1251 NAD(P)H-nitrite reductase; Psort location: cytoplasmic, score: 23 YP_001440384.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001440385.1 KEGG: stm:STM3472 2.8e-88 ppiA; peptidyl-prolyl cis-trans isomerase A (rotamase A) K03767; COG: COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family; Psort location: extracellular, including cell wall, score: 9 YP_001440386.1 COG: NOG18128 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001440387.1 COG: COG2184 Protein involved in cell division; Psort location: cytoplasmic, score: 23 YP_001440388.1 KEGG: ypa:YPA_3300 5.1e-73 para-aminobenzoate synthase glutamine amidotransferase component II K01664; COG: COG0512 Anthranilate/para-aminobenzoate synthases component II; Psort location: cytoplasmic, score: 23 YP_001440389.1 DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate YP_001440390.1 KEGG: ssn:SSO_3489 1.1e-290 yhfK; hypothetical protein K01823; COG: COG1289 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001440391.1 complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons YP_001440392.1 COG: COG1765 Predicted redox protein, regulator of disulfide bond formation; Psort location: cytoplasmic, score: 23 YP_001440393.1 KEGG: spt:SPA3330 2.0e-149 prkB; phosphoribulokinase K00855; COG: COG3954 Phosphoribulokinase; Psort location: cytoplasmic, score: 23 YP_001440394.1 COG: COG3089 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001440395.1 COG: COG0429 Predicted hydrolase of the alpha/beta-hydrolase fold; Psort location: cytoplasmic, score: 23 YP_001440396.1 Psort location: mitochondrial, score: 23 YP_001440397.1 KEGG: mth:MTH1315 6.7e-16 mutator MutT protein K01529; COG: COG1051 ADP-ribose pyrophosphatase; Psort location: cytoplasmic, score: 23 YP_001440398.1 KEGG: chu:CHU_2422 1.3e-35 prsA; phosphoribosylpyrophosphate synthetase K00948; COG: COG0462 Phosphoribosylpyrophosphate synthetase; Psort location: cytoplasmic, score: 23 YP_001440399.1 KEGG: chu:CHU_2424 4.3e-124 nadV; nicotinamide phosphoribosyl transferase family protein K00763; COG: COG1488 Nicotinic acid phosphoribosyltransferase; Psort location: cytoplasmic, score: 23 YP_001440400.1 Psort location: endoplasmic reticulum, score: 9 YP_001440401.1 COG: COG3853 Uncharacterized protein involved in tellurite resistance; Psort location: cytoplasmic, score: 23 YP_001440402.1 KEGG: bur:Bcep18194_A5345 6.6e-183 ABC transporter, fused ATPase subunits K06158; COG: COG0488 ATPase components of ABC transporters with duplicated ATPase domains; Psort location: mitochondrial, score: 23 YP_001440403.1 required for KefB activity YP_001440404.1 involved in potassium efflux YP_001440405.1 KEGG: syc:syc2139_c 0.0017 accD; acetyl-CoA carboxylase beta subunit K01963; COG: COG3529 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain; Psort location: extracellular, including cell wall, score: 9 YP_001440406.1 Psort location: endoplasmic reticulum, score: 9 YP_001440407.1 rotamase YP_001440408.1 COG: COG2900 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001440409.1 rotamase YP_001440410.1 COG: COG2964 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001440411.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs YP_001440412.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs YP_001440413.1 COG: COG2168 Uncharacterized conserved protein involved in oxidation of intracellular sulfur; Psort location: cytoplasmic, score: 23 YP_001440415.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_001440416.1 COG: NOG09977 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001440417.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_001440418.1 Psort location: cytoplasmic, score: 23 YP_001440419.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_001440420.1 Psort location: mitochondrial, score: 23 YP_001440421.1 iron storage protein YP_001440422.1 KEGG: csa:Csal_2176 4.1e-32 prepilin peptidase; COG: COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases; Psort location: endoplasmic reticulum, score: 9 YP_001440423.1 Psort location: mitochondrial, score: 23; ORF located using Blastx YP_001440424.1 COG: NOG23110 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001440425.1 COG: NOG22282 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001440426.1 KEGG: noc:Noc_1464 3.5e-26 micrococcal nuclease (SNase-like) K01174; COG: COG1525 Micrococcal nuclease (thermonuclease) homologs; Psort location: extracellular, including cell wall, score: 9 YP_001440427.1 Psort location: endoplasmic reticulum, score: 9 YP_001440428.1 Psort location: nuclear, score: 23 YP_001440429.1 COG: NOG35487 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001440430.1 COG: NOG19677 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001440431.1 KEGG: sil:SPO1049 2.1e-83 DNA methylase, C-5 cytosine-specific family K00558; COG: COG0270 Site-specific DNA methylase; Psort location: cytoplasmic, score: 23 YP_001440432.1 COG: COG1961 Site-specific recombinases, DNA invertase Pin homologs; Psort location: cytoplasmic, score: 23 YP_001440433.1 COG: NOG33302 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001440434.1 Psort location: endoplasmic reticulum, score: 9 YP_001440435.1 Psort location: mitochondrial, score: 23 YP_001440436.1 KEGG: aci:ACIAD0086 3.8e-06 epsM; bifunctional protein [includes: mannose-6-phosphate isomerase (phosphomannose isomerase) (PMI) (phosphohexomutase); mannose-1-phosphate guanylyl transferase (GDP) (GDP-mannose pyrophosphorylase) (GMP)] K00971:K01809; COG: COG1917 Uncharacterized conserved protein, contains double-stranded beta-helix domain; Psort location: cytoplasmic, score: 23 YP_001440437.1 KEGG: mma:MM1164 1.1e-15 hypothetical nucleotidyltransferase; COG: COG2361 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001440438.1 KEGG: tth:TTC1285 1.3e-12 nucleotidyltransferase; COG: COG1669 Predicted nucleotidyltransferases; Psort location: cytoplasmic, score: 23 YP_001440439.1 COG: COG4644 Transposase and inactivated derivatives, TnpA family; Psort location: cytoplasmic, score: 23 YP_001440440.1 Psort location: nuclear, score: 23 YP_001440441.1 Psort location: extracellular, including cell wall, score: 9 YP_001440442.1 Psort location: mitochondrial, score: 23 YP_001440443.1 COG: COG1396 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001440444.1 COG: COG0250 Transcription antiterminator; Psort location: cytoplasmic, score: 23; ORF located using Blastx YP_001440445.1 Psort location: nuclear, score: 23 YP_001440446.1 COG: NOG33328 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001440447.1 COG: NOG17192 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001440448.1 COG: NOG22876 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001440449.1 COG: COG3451 Type IV secretory pathway, VirB4 components; Psort location: endoplasmic reticulum, score: 9 YP_001440450.1 COG: NOG13363 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001440451.1 Psort location: extracellular, including cell wall, score: 9 YP_001440452.1 COG: COG3704 Type IV secretory pathway, VirB6 components; Psort location: endoplasmic reticulum, score: 9 YP_001440453.1 Psort location: extracellular, including cell wall, score: 9 YP_001440454.1 COG: COG3736 Type IV secretory pathway, component VirB8; Psort location: endoplasmic reticulum, score: 9 YP_001440455.1 COG: COG3504 Type IV secretory pathway, VirB9 components; Psort location: extracellular, including cell wall, score: 9 YP_001440456.1 COG: COG2948 Type IV secretory pathway, VirB10 components; Psort location: nuclear, score: 23 YP_001440457.1 KEGG: reh:H16_A0983 1.5e-22 cpaF3; flp pilus assembly ATPase CpaF K01529; COG: COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis; Psort location: cytoplasmic, score: 23 YP_001440458.1 Psort location: extracellular, including cell wall, score: 9; ORF located using Blastx YP_001440459.1 COG: NOG33965 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001440460.1 Psort location: nuclear, score: 23 YP_001440461.1 KEGG: rso:RSc0499 7.0e-21 gpmB, RS05023; putative phosphoglycerate mutase 2 protein K01834; COG: COG0406 Fructose-2,6-bisphosphatase; Psort location: cytoplasmic, score: 23 YP_001440462.1 COG: COG4705 Uncharacterized membrane-anchored protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001440463.1 COG: NOG12552 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001440464.1 KEGG: ddi:DDB0216844 7.6e-15 hypothetical protein K00676; COG: COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins; Psort location: cytoplasmic, score: 23 YP_001440465.1 KEGG: fal:FRAAL6580 1.8e-06 tmk; thymidylate kinase (dTMP kinase) (partial match) K00943; COG: NOG06507 non supervised orthologous group; Psort location: plasma membrane, score: 23 YP_001440466.1 Psort location: cytoplasmic, score: 23 YP_001440467.1 outer membrane protease; involved in virulence in many organisms; OmpT; IcsP; SopA; Pla; PgtE; omptin; in Escherichia coli OmpT can degrade antimicrobial peptides; in Yersinia Pla activates plasminogen during infection; in Shigella flexneria SopA cleaves the autotransporter IcsA YP_001440468.1 Psort location: extracellular, including cell wall, score: 9 YP_001440469.1 Psort location: extracellular, including cell wall, score: 9 YP_001440470.1 COG: COG2378 Predicted transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001440471.1 COG: COG0346 Lactoylglutathione lyase and related lyases; Psort location: cytoplasmic, score: 23 YP_001440472.1 COG: NOG11449 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001440473.1 COG: COG3713 Outer membrane protein V; Psort location: extracellular, including cell wall, score: 9 YP_001440474.1 KEGG: rru:Rru_A2929 5.0e-50 two component transcriptional regulator, winged helix family; COG: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; Psort location: cytoplasmic, score: 23 YP_001440475.1 KEGG: xac:XAC2804 2.6e-85 baeS; two-component system sensor protein K07642; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 9 YP_001440476.1 KEGG: pat:Patl_1800 0.0026 2-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase K00658; COG: COG0845 Membrane-fusion protein; Psort location: endoplasmic reticulum, score: 9 YP_001440477.1 KEGG: eci:UTI89_C2351 2.0e-62 yegO; hypothetical protein YegO K07789; COG: COG0841 Cation/multidrug efflux pump; Psort location: plasma membrane, score: 23 YP_001440478.1 COG: NOG16264 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001440479.1 KEGG: gka:GK3067 1.4e-08 NTP pyrophosphohydrolases including oxidative damage repair enzymes K01529; COG: NOG15944 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001440480.1 COG: COG2318 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001440481.1 COG: NOG08503 non supervised orthologous group; Psort location: plasma membrane, score: 23 YP_001440482.1 KEGG: bha:BH3415 0.0098 NADH dehydrogenase K03885; COG: NOG16009 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001440483.1 KEGG: cal:orf19.2425 1.0e-07 highly conserved hypothetical protein K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001440484.1 KEGG: fal:FRAAL3539 0.0073 putative oxidoreductase, NAD(P)-binding domain K00059; COG: COG0725 ABC-type molybdate transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001440485.1 KEGG: shn:Shewana3_3435 1.2e-14 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: endoplasmic reticulum, score: 9 YP_001440486.1 COG: NOG21364 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001440487.1 COG: NOG18230 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001440488.1 COG: NOG18299 non supervised orthologous group; Psort location: cytoskeletal, score: 9 YP_001440489.1 KEGG: cvi:CV0835 2.9e-15 icc; 3',5'-cyclic-nucleotide phosphodiesterase K03651; COG: COG1409 Predicted phosphohydrolases; Psort location: cytoplasmic, score: 23 YP_001440490.1 Psort location: cytoplasmic, score: 23 YP_001440491.1 COG: NOG23111 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001440492.1 Psort location: nuclear, score: 23 YP_001440493.1 Psort location: cytoplasmic, score: 23 YP_001440494.1 Psort location: nuclear, score: 23 YP_001440495.1 KEGG: shn:Shewana3_3829 3.3e-13 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) K01745; COG: COG2200 FOG: EAL domain; Psort location: cytoplasmic, score: 23 YP_001440496.1 KEGG: eci:UTI89_C3737 1.9e-07 yhdM; Zn(II)-responsive regulator of ZntA; COG: COG0789 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001440497.1 KEGG: cps:CPS_1826 1.0e-05 torS; sensor protein TorS K07647; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 9 YP_001440498.1 KEGG: vfi:VFA0660 1.1e-22 prolyl endopeptidase K01322; COG: NOG18075 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001440499.1 KEGG: reh:H16_A0240 2.0e-07 acetyltransferase (GNAT) family K00680; COG: NOG16606 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001440500.1 Psort location: extracellular, including cell wall, score: 9 YP_001440501.1 COG: COG2329 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides; Psort location: cytoplasmic, score: 23 YP_001440502.1 KEGG: afu:AF1672 5.1e-09 acetolactate synthase small subunit K01653; COG: NOG28140 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001440503.1 KEGG: rru:Rru_A1450 7.7e-05 transcriptional regulator, ArsR family; COG: COG0640 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001440504.1 KEGG: psb:Psyr_4478 3.7e-109 alpha/beta hydrolase fold K00433; COG: COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily); Psort location: endoplasmic reticulum, score: 23 YP_001440505.1 KEGG: lwe:lwe0269 7.1e-99 PTS system, beta-glucoside-specific IIABC component K00890; COG: COG1264 Phosphotransferase system IIB components; Psort location: plasma membrane, score: 23 YP_001440506.1 KEGG: eci:UTI89_C1768 4.6e-72 rspA; starvation sensing protein RspA K08323; COG: COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001440507.1 KEGG: btk:BT9727_3183 2.8e-11 transcriptional regulator, GntR family; COG: COG2188 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001440508.1 KEGG: ape:APE_0256a.1 0.00024 DNA-directed RNA polymerase,subunit E K03050; COG: COG2314 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001440509.1 COG: NOG23795 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001440510.1 Psort location: mitochondrial, score: 23 YP_001440511.1 KEGG: ava:Ava_1030 3.1e-31 putative diguanylate cyclase (GGDEF domain) K02488; COG: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; Psort location: endoplasmic reticulum, score: 9 YP_001440512.1 KEGG: bms:BR0643 0.0028 transglycosylase SLT domain protein K01238; Psort location: nuclear, score: 23 YP_001440513.1 Psort location: cytoplasmic, score: 23 YP_001440514.1 COG: COG3157 Hemolysin-coregulated protein (uncharacterized); Psort location: mitochondrial, score: 23 YP_001440515.1 Psort location: endoplasmic reticulum, score: 23 YP_001440516.1 KEGG: mmp:MMP1692 0.0084 vhuB; polyferredoxin, associated with F420-non-reducing hydrogenase; COG: COG1145 Ferredoxin; Psort location: nuclear, score: 23 YP_001440517.1 KEGG: shn:Shewana3_0031 2.9e-63 potassium uptake protein, TrkH family K00961; COG: COG0168 Trk-type K+ transport systems, membrane components; Psort location: plasma membrane, score: 23 YP_001440518.1 KEGG: ecj:JW3470 3.9e-50 arsC; arsenate reductase K00537; COG: COG1393 Arsenate reductase and related proteins, glutaredoxin family; Psort location: nuclear, score: 23 YP_001440519.1 KEGG: ecj:JW3469 1.1e-180 arsB; arsenite/antimonite transporter K03893; COG: COG1055 Na+/H+ antiporter NhaD and related arsenite permeases; Psort location: plasma membrane, score: 23 YP_001440520.1 KEGG: rru:Rru_A1450 2.0e-13 transcriptional regulator, ArsR family; COG: COG0640 Predicted transcriptional regulators; Psort location: nuclear, score: 23 YP_001440521.1 KEGG: plu:plu1530 2.6e-78 unnamed protein product; similar to dihydrodipicolinate synthetase K01714; COG: COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase; Psort location: extracellular, including cell wall, score: 9 YP_001440522.1 COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: plasma membrane, score: 23 YP_001440523.1 KEGG: reh:H16_B1957 2.9e-125 transcriptional regulator, MocR family; COG: COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs; Psort location: cytoplasmic, score: 23 YP_001440524.1 COG: COG3516 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001440525.1 KEGG: bpm:BURPS1710b_A0534 3.0e-116 hypothetical protein K00356; COG: COG3517 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001440526.1 COG: COG3522 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001440527.1 COG: COG3455 Uncharacterized protein conserved in bacteria; Psort location: vesicles of secretory system, score: 9 YP_001440528.1 KEGG: bma:BMA3197 0.0051 coxB; cytochrome c oxidase, subunit II K02275; COG: COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins; Psort location: golgi, score: 9 YP_001440529.1 COG: COG3157 Hemolysin-coregulated protein (uncharacterized); Psort location: cytoplasmic, score: 23 YP_001440530.1 KEGG: eci:UTI89_C3197 0. ClpB protein K01358; COG: COG0542 ATPases with chaperone activity, ATP-binding subunit; Psort location: cytoplasmic, score: 23 YP_001440531.1 COG: COG4253 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001440532.1 Psort location: cytoplasmic, score: 23 YP_001440533.1 KEGG: saz:Sama_1205 3.3e-06 peptidyl-Lys metalloendopeptidase K08646; COG: COG3501 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001440534.1 Psort location: nuclear, score: 23 YP_001440535.1 Psort location: extracellular, including cell wall, score: 9 YP_001440536.1 COG: NOG36642 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001440537.1 COG: COG4104 Uncharacterized conserved protein; Psort location: vesicles of secretory system, score: 9; ORF located using Blastx YP_001440538.1 Psort location: cytoplasmic, score: 23 YP_001440539.1 COG: COG3521 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001440540.1 KEGG: eci:UTI89_C0607 5.4e-69 dsbG; thiol:disulfide interchange protein DsbG precursor K03805; COG: COG1651 Protein-disulfide isomerase; Psort location: extracellular, including cell wall, score: 23 YP_001440541.1 KEGG: xoo:XOO0561 4.3e-60 dsbD; C-type cytochrome biogenesis protein (copper tolerance) K04084; COG: COG4233 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis; Psort location: endoplasmic reticulum, score: 9 YP_001440542.1 COG: NOG29928 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001440543.1 Psort location: endoplasmic reticulum, score: 9 YP_001440544.1 Psort location: cytoplasmic, score: 23 YP_001440545.1 Psort location: cytoplasmic, score: 23 YP_001440546.1 Psort location: cytoplasmic, score: 23 YP_001440547.1 Psort location: mitochondrial, score: 23 YP_001440548.1 COG: NOG13879 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001440549.1 KEGG: ret:RHE_PF00271 1.3e-90 probable iron ABC transporter, ATP-binding protein K02013; COG: COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components; Psort location: cytoplasmic, score: 23 YP_001440550.1 COG: COG0609 ABC-type Fe3+-siderophore transport system, permease component; Psort location: endoplasmic reticulum, score: 23 YP_001440551.1 COG: COG0614 ABC-type Fe3+-hydroxamate transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001440552.1 KEGG: gsu:GSU3029 1.5e-11 long-chain-fatty-acid--[acyl-carrier-protein] ligase / acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase K05939:K01909; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001440553.1 COG: COG4974 Site-specific recombinase XerD; Psort location: cytoplasmic, score: 23 YP_001440554.1 COG: NOG28530 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001440555.1 COG: NOG28669 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001440556.1 KEGG: psb:Psyr_3842 0.00023 SNF2-related:helicase, C-terminal:type III restriction enzyme, res subunit K03580; COG: NOG25072 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001440557.1 KEGG: pen:PSEEN0676 3.0e-43 oxidoreductase, short chain dehydrogenase/reductase family; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001440558.1 COG: NOG17257 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001440559.1 Psort location: cytoplasmic, score: 23 YP_001440560.1 KEGG: lpl:lp_3093 2.3e-05 muramidase (putative) K01185; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: plasma membrane, score: 23 YP_001440561.1 KEGG: rha:RHA1_ro06806 4.5e-07 probable hydroxyacylglutathione hydrolase K01069; COG: NOG09919 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001440562.1 Catalyzes the deamination of guanine YP_001440563.1 KEGG: bur:Bcep18194_B2557 6.5e-25 glutathione S-transferase-like K00799; COG: COG0625 glutathione S-transferase; Psort location: cytoplasmic, score: 23 YP_001440564.1 Psort location: cytoplasmic, score: 23 YP_001440565.1 KEGG: mma:MM2965 4.1e-21 hypothetical sensory transduction histidine kinase; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 9 YP_001440566.1 KEGG: ama:AM949 8.6e-08 clpB; ATP-dependent clp protease ATP-binding subunit K03695; COG: COG0542 ATPases with chaperone activity, ATP-binding subunit; Psort location: cytoplasmic, score: 23 YP_001440567.1 Psort location: nuclear, score: 23 YP_001440568.1 COG: COG0814 Amino acid permeases; Psort location: plasma membrane, score: 23 YP_001440569.1 KEGG: stm:STM3763 0. mgtB; Mg2+ transport protein K01531; COG: COG0474 Cation transport ATPase; Psort location: plasma membrane, score: 23 YP_001440570.1 COG: COG2850 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001440571.1 Psort location: nuclear, score: 23 YP_001440572.1 KEGG: chu:CHU_0837 2.4e-16 CHU large protein; uncharacterized K01238; COG: COG2931 RTX toxins and related Ca2+-binding proteins; Psort location: extracellular, including cell wall, score: 9 YP_001440573.1 KEGG: stm:STM1558 0. putative glycosyl hydrolase K02438; COG: COG1523 Type II secretory pathway, pullulanase PulA and related glycosidases; Psort location: cytoplasmic, score: 23 YP_001440574.1 KEGG: ret:RHE_PE00008 2.2e-207 putative maltooligosyl trehalose synthase protein; COG: COG3280 Maltooligosyl trehalose synthase; Psort location: cytoplasmic, score: 23 YP_001440575.1 KEGG: sme:SMb21447 4.3e-147 glgB2; putative 1,4-alpha-glucan branching enzyme protein K00700; COG: COG0296 1,4-alpha-glucan branching enzyme; Psort location: endoplasmic reticulum, score: 9 YP_001440576.1 COG: COG3550 Uncharacterized protein related to capsule biosynthesis enzymes; Psort location: cytoplasmic, score: 23 YP_001440577.1 KEGG: afu:AF2118 0.0061 guaB-2; IMP dehydrogenase K00088; COG: NOG36203 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001440578.1 COG: COG2375 Siderophore-interacting protein; Psort location: mitochondrial, score: 23 YP_001440579.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001440580.1 KEGG: yps:YPTB3263 5.6e-225 rhbC, iucA; possible siderophore biosynthesis protein, IucA familly K03894; COG: COG4264 Siderophore synthetase component; Psort location: cytoplasmic, score: 23 YP_001440581.1 KEGG: yps:YPTB3264 9.9e-125 iucB; putative siderophore biosynthesis protein IucB K03896; COG: COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins; Psort location: cytoplasmic, score: 23 YP_001440582.1 KEGG: yps:YPTB3265 4.1e-229 iucC; putative siderophore biosynthesis protein IucC K03895; COG: COG4264 Siderophore synthetase component; Psort location: cytoplasmic, score: 23 YP_001440583.1 KEGG: yps:YPTB3266 3.5e-161 iucD; putative siderophore biosynthesis protein IucD K03897; COG: COG3486 Lysine/ornithine N-monooxygenase; Psort location: cytoplasmic, score: 23 YP_001440584.1 COG: COG1629 Outer membrane receptor proteins, mostly Fe transport; Psort location: cytoplasmic, score: 23 YP_001440585.1 Psort location: cytoplasmic, score: 23 YP_001440586.1 COG: COG1475 Predicted transcriptional regulators; Psort location: mitochondrial, score: 23 YP_001440587.1 KEGG: pha:PSHAa0816 6.4e-10 partitioning protein A K00903; COG: COG1192 ATPases involved in chromosome partitioning; Psort location: cytoplasmic, score: 23