-- dump date 20140619_053704 -- class Genbank::misc_feature -- table misc_feature_note -- id note 290339000001 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 290339000002 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 290339000003 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 290339000004 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 290339000005 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 290339000006 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 290339000007 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 290339000008 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 290339000009 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 290339000010 protein-rRNA interface [nucleotide binding]; other site 290339000011 putative translocon binding site; other site 290339000012 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 290339000013 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 290339000014 G-X-X-G motif; other site 290339000015 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 290339000016 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 290339000017 L27 interface [polypeptide binding]; other site 290339000018 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 290339000019 23S rRNA interface [nucleotide binding]; other site 290339000020 putative translocon interaction site; other site 290339000021 signal recognition particle (SRP54) interaction site; other site 290339000022 L23 interface [polypeptide binding]; other site 290339000023 trigger factor interaction site; other site 290339000024 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 290339000025 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 290339000026 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 290339000027 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 290339000028 RNA binding site [nucleotide binding]; other site 290339000029 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 290339000030 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 290339000031 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 290339000032 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 290339000033 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 290339000034 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 290339000035 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 290339000036 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 290339000037 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 290339000038 23S rRNA interface [nucleotide binding]; other site 290339000039 5S rRNA interface [nucleotide binding]; other site 290339000040 L27 interface [polypeptide binding]; other site 290339000041 L5 interface [polypeptide binding]; other site 290339000042 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 290339000043 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 290339000044 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 290339000045 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 290339000046 23S rRNA binding site [nucleotide binding]; other site 290339000047 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 290339000048 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 290339000049 SecY translocase; Region: SecY; pfam00344 290339000050 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 290339000051 alpha operon ribosome binding site 290339000052 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 290339000053 30S ribosomal protein S13; Region: bact_S13; TIGR03631 290339000054 30S ribosomal protein S11; Validated; Region: PRK05309 290339000055 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 290339000056 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 290339000057 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 290339000058 RNA binding surface [nucleotide binding]; other site 290339000059 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 290339000060 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 290339000061 alphaNTD homodimer interface [polypeptide binding]; other site 290339000062 alphaNTD - beta interaction site [polypeptide binding]; other site 290339000063 alphaNTD - beta' interaction site [polypeptide binding]; other site 290339000064 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 290339000065 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 290339000066 hypothetical protein; Provisional; Region: PRK10203 290339000067 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 290339000068 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 290339000069 DNA binding residues [nucleotide binding] 290339000070 dimer interface [polypeptide binding]; other site 290339000071 metal binding site [ion binding]; metal-binding site 290339000072 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 290339000073 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 290339000074 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 290339000075 TrkA-N domain; Region: TrkA_N; pfam02254 290339000076 TrkA-C domain; Region: TrkA_C; pfam02080 290339000077 TrkA-N domain; Region: TrkA_N; pfam02254 290339000078 TrkA-C domain; Region: TrkA_C; pfam02080 290339000079 16S rRNA methyltransferase B; Provisional; Region: PRK10901 290339000080 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 290339000081 putative RNA binding site [nucleotide binding]; other site 290339000082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290339000083 S-adenosylmethionine binding site [chemical binding]; other site 290339000084 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 290339000085 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 290339000086 putative active site [active] 290339000087 substrate binding site [chemical binding]; other site 290339000088 putative cosubstrate binding site; other site 290339000089 catalytic site [active] 290339000090 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 290339000091 substrate binding site [chemical binding]; other site 290339000092 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 290339000093 active site 290339000094 catalytic residues [active] 290339000095 metal binding site [ion binding]; metal-binding site 290339000096 hypothetical protein; Provisional; Region: PRK10736 290339000097 DNA protecting protein DprA; Region: dprA; TIGR00732 290339000098 hypothetical protein; Validated; Region: PRK03430 290339000099 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 290339000100 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 290339000101 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 290339000102 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 290339000103 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 290339000104 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 290339000105 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 290339000106 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 290339000107 shikimate binding site; other site 290339000108 NAD(P) binding site [chemical binding]; other site 290339000109 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 290339000110 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 290339000111 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 290339000112 trimer interface [polypeptide binding]; other site 290339000113 putative metal binding site [ion binding]; other site 290339000114 homoserine O-succinyltransferase; Provisional; Region: PRK05368 290339000115 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 290339000116 proposed active site lysine [active] 290339000117 conserved cys residue [active] 290339000118 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 290339000119 malate synthase A; Region: malate_syn_A; TIGR01344 290339000120 active site 290339000121 isocitrate lyase; Provisional; Region: PRK15063 290339000122 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 290339000123 tetramer interface [polypeptide binding]; other site 290339000124 active site 290339000125 Mg2+/Mn2+ binding site [ion binding]; other site 290339000126 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 290339000127 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 290339000128 transcriptional repressor IclR; Provisional; Region: PRK11569 290339000129 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 290339000130 Bacterial transcriptional regulator; Region: IclR; pfam01614 290339000131 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 290339000132 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 290339000133 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 290339000134 substrate binding pocket [chemical binding]; other site 290339000135 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 290339000136 B12 binding site [chemical binding]; other site 290339000137 cobalt ligand [ion binding]; other site 290339000138 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 290339000139 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 290339000140 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 290339000141 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 290339000142 hypothetical protein; Provisional; Region: PRK10515 290339000143 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 290339000144 Sodium Bile acid symporter family; Region: SBF; pfam01758 290339000145 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 290339000146 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 290339000147 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290339000148 Walker A motif; other site 290339000149 ATP binding site [chemical binding]; other site 290339000150 Walker B motif; other site 290339000151 arginine finger; other site 290339000152 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 290339000153 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 290339000154 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 290339000155 hypothetical protein; Reviewed; Region: PRK09588 290339000156 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 290339000157 aspartate kinase III; Validated; Region: PRK09084 290339000158 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 290339000159 nucleotide binding site [chemical binding]; other site 290339000160 substrate binding site [chemical binding]; other site 290339000161 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 290339000162 lysine allosteric regulatory site; other site 290339000163 dimer interface [polypeptide binding]; other site 290339000164 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 290339000165 dimer interface [polypeptide binding]; other site 290339000166 lysine riboswitch 290339000167 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 290339000168 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 290339000169 active site 290339000170 dimer interface [polypeptide binding]; other site 290339000171 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 290339000172 dimer interface [polypeptide binding]; other site 290339000173 active site 290339000174 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 290339000175 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 290339000176 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 290339000177 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 290339000178 putative trimer interface [polypeptide binding]; other site 290339000179 putative active site [active] 290339000180 putative substrate binding site [chemical binding]; other site 290339000181 putative CoA binding site [chemical binding]; other site 290339000182 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290339000183 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339000184 dimer interface [polypeptide binding]; other site 290339000185 conserved gate region; other site 290339000186 putative PBP binding loops; other site 290339000187 ABC-ATPase subunit interface; other site 290339000188 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339000189 dimer interface [polypeptide binding]; other site 290339000190 conserved gate region; other site 290339000191 ABC-ATPase subunit interface; other site 290339000192 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 290339000193 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290339000194 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 290339000195 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 290339000196 Walker A/P-loop; other site 290339000197 ATP binding site [chemical binding]; other site 290339000198 Q-loop/lid; other site 290339000199 ABC transporter signature motif; other site 290339000200 Walker B; other site 290339000201 D-loop; other site 290339000202 H-loop/switch region; other site 290339000203 TOBE domain; Region: TOBE_2; pfam08402 290339000204 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 290339000205 trimer interface; other site 290339000206 sugar binding site [chemical binding]; other site 290339000207 maltose regulon periplasmic protein; Provisional; Region: PRK10564 290339000208 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 290339000209 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 290339000210 UbiA prenyltransferase family; Region: UbiA; pfam01040 290339000211 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 290339000212 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 290339000213 putative acyl-acceptor binding pocket; other site 290339000214 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 290339000215 LexA repressor; Validated; Region: PRK00215 290339000216 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 290339000217 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 290339000218 Catalytic site [active] 290339000219 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 290339000220 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 290339000221 hypothetical protein; Provisional; Region: PRK10428 290339000222 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 290339000223 metal binding site 2 [ion binding]; metal-binding site 290339000224 putative DNA binding helix; other site 290339000225 metal binding site 1 [ion binding]; metal-binding site 290339000226 dimer interface [polypeptide binding]; other site 290339000227 structural Zn2+ binding site [ion binding]; other site 290339000228 Cupin domain; Region: Cupin_2; cl17218 290339000229 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 290339000230 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 290339000231 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 290339000232 FMN binding site [chemical binding]; other site 290339000233 active site 290339000234 catalytic residues [active] 290339000235 substrate binding site [chemical binding]; other site 290339000236 phage shock protein G; Reviewed; Region: pspG; PRK09459 290339000237 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 290339000238 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 290339000239 NADP binding site [chemical binding]; other site 290339000240 dimer interface [polypeptide binding]; other site 290339000241 replicative DNA helicase; Provisional; Region: PRK08006 290339000242 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 290339000243 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 290339000244 Walker A motif; other site 290339000245 ATP binding site [chemical binding]; other site 290339000246 Walker B motif; other site 290339000247 DNA binding loops [nucleotide binding] 290339000248 alanine racemase; Reviewed; Region: alr; PRK00053 290339000249 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 290339000250 active site 290339000251 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 290339000252 substrate binding site [chemical binding]; other site 290339000253 catalytic residues [active] 290339000254 dimer interface [polypeptide binding]; other site 290339000255 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 290339000256 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290339000257 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339000258 homodimer interface [polypeptide binding]; other site 290339000259 catalytic residue [active] 290339000260 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 290339000261 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 290339000262 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 290339000263 Uncharacterized conserved protein [Function unknown]; Region: COG0432 290339000264 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 290339000265 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 290339000266 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 290339000267 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 290339000268 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 290339000269 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 290339000270 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 290339000271 dimer interface [polypeptide binding]; other site 290339000272 ssDNA binding site [nucleotide binding]; other site 290339000273 tetramer (dimer of dimers) interface [polypeptide binding]; other site 290339000274 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 290339000275 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290339000276 metal binding site [ion binding]; metal-binding site 290339000277 active site 290339000278 I-site; other site 290339000279 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 290339000280 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 290339000281 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290339000282 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 290339000283 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290339000284 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 290339000285 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 290339000286 DNA binding residues [nucleotide binding] 290339000287 dimer interface [polypeptide binding]; other site 290339000288 [2Fe-2S] cluster binding site [ion binding]; other site 290339000289 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 290339000290 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 290339000291 putative C-terminal domain interface [polypeptide binding]; other site 290339000292 putative GSH binding site (G-site) [chemical binding]; other site 290339000293 putative dimer interface [polypeptide binding]; other site 290339000294 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 290339000295 putative N-terminal domain interface [polypeptide binding]; other site 290339000296 putative dimer interface [polypeptide binding]; other site 290339000297 putative substrate binding pocket (H-site) [chemical binding]; other site 290339000298 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 290339000299 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 290339000300 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 290339000301 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290339000302 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290339000303 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290339000304 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 290339000305 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 290339000306 Na binding site [ion binding]; other site 290339000307 Predicted membrane protein [Function unknown]; Region: COG3162 290339000308 acetyl-CoA synthetase; Provisional; Region: PRK00174 290339000309 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 290339000310 active site 290339000311 CoA binding site [chemical binding]; other site 290339000312 acyl-activating enzyme (AAE) consensus motif; other site 290339000313 AMP binding site [chemical binding]; other site 290339000314 acetate binding site [chemical binding]; other site 290339000315 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 290339000316 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 290339000317 Hok/gef family; Region: HOK_GEF; pfam01848 290339000318 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 290339000319 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290339000320 ATP binding site [chemical binding]; other site 290339000321 Mg2+ binding site [ion binding]; other site 290339000322 G-X-G motif; other site 290339000323 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 290339000324 hypothetical protein; Provisional; Region: PRK10220 290339000325 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 290339000326 PhnA protein; Region: PhnA; pfam03831 290339000327 hypothetical protein; Provisional; Region: PRK09866 290339000328 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 290339000329 G1 box; other site 290339000330 GTP/Mg2+ binding site [chemical binding]; other site 290339000331 G2 box; other site 290339000332 Switch I region; other site 290339000333 G3 box; other site 290339000334 Switch II region; other site 290339000335 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 290339000336 G3 box; other site 290339000337 Switch II region; other site 290339000338 G4 box; other site 290339000339 G5 box; other site 290339000340 YjcZ-like protein; Region: YjcZ; pfam13990 290339000341 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 290339000342 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 290339000343 putative S-transferase; Provisional; Region: PRK11752 290339000344 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 290339000345 C-terminal domain interface [polypeptide binding]; other site 290339000346 GSH binding site (G-site) [chemical binding]; other site 290339000347 dimer interface [polypeptide binding]; other site 290339000348 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 290339000349 dimer interface [polypeptide binding]; other site 290339000350 N-terminal domain interface [polypeptide binding]; other site 290339000351 active site 290339000352 High-affinity nickel-transport protein; Region: NicO; cl00964 290339000353 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 290339000354 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 290339000355 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 290339000356 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 290339000357 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 290339000358 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 290339000359 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 290339000360 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 290339000361 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 290339000362 putative transcriptional regulator; Provisional; Region: PRK11640 290339000363 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 290339000364 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 290339000365 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 290339000366 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 290339000367 DsbD alpha interface [polypeptide binding]; other site 290339000368 catalytic residues [active] 290339000369 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 290339000370 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 290339000371 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 290339000372 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 290339000373 Aspartase; Region: Aspartase; cd01357 290339000374 active sites [active] 290339000375 tetramer interface [polypeptide binding]; other site 290339000376 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 290339000377 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 290339000378 oligomerisation interface [polypeptide binding]; other site 290339000379 mobile loop; other site 290339000380 roof hairpin; other site 290339000381 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 290339000382 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 290339000383 ring oligomerisation interface [polypeptide binding]; other site 290339000384 ATP/Mg binding site [chemical binding]; other site 290339000385 stacking interactions; other site 290339000386 hinge regions; other site 290339000387 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 290339000388 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 290339000389 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290339000390 FeS/SAM binding site; other site 290339000391 elongation factor P; Validated; Region: PRK00529 290339000392 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 290339000393 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 290339000394 RNA binding site [nucleotide binding]; other site 290339000395 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 290339000396 RNA binding site [nucleotide binding]; other site 290339000397 entericidin A; Provisional; Region: PRK09810 290339000398 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290339000399 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290339000400 DNA binding residues [nucleotide binding] 290339000401 dimerization interface [polypeptide binding]; other site 290339000402 multidrug efflux system protein; Provisional; Region: PRK11431 290339000403 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 290339000404 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 290339000405 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 290339000406 Iron-sulfur protein interface; other site 290339000407 proximal quinone binding site [chemical binding]; other site 290339000408 C-subunit interface; other site 290339000409 distal quinone binding site; other site 290339000410 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 290339000411 D-subunit interface [polypeptide binding]; other site 290339000412 Iron-sulfur protein interface; other site 290339000413 proximal quinone binding site [chemical binding]; other site 290339000414 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 290339000415 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 290339000416 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 290339000417 L-aspartate oxidase; Provisional; Region: PRK06175 290339000418 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 290339000419 poxB regulator PoxA; Provisional; Region: PRK09350 290339000420 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 290339000421 motif 1; other site 290339000422 dimer interface [polypeptide binding]; other site 290339000423 active site 290339000424 motif 2; other site 290339000425 motif 3; other site 290339000426 putative mechanosensitive channel protein; Provisional; Region: PRK10929 290339000427 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 290339000428 Mechanosensitive ion channel; Region: MS_channel; pfam00924 290339000429 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 290339000430 ribosome small subunit-dependent GTPase A; Region: TIGR00157 290339000431 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 290339000432 GTPase/Zn-binding domain interface [polypeptide binding]; other site 290339000433 GTP/Mg2+ binding site [chemical binding]; other site 290339000434 G4 box; other site 290339000435 G5 box; other site 290339000436 G1 box; other site 290339000437 Switch I region; other site 290339000438 G2 box; other site 290339000439 G3 box; other site 290339000440 Switch II region; other site 290339000441 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 290339000442 catalytic site [active] 290339000443 putative active site [active] 290339000444 putative substrate binding site [chemical binding]; other site 290339000445 dimer interface [polypeptide binding]; other site 290339000446 epoxyqueuosine reductase; Region: TIGR00276 290339000447 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 290339000448 putative carbohydrate kinase; Provisional; Region: PRK10565 290339000449 Uncharacterized conserved protein [Function unknown]; Region: COG0062 290339000450 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 290339000451 putative substrate binding site [chemical binding]; other site 290339000452 putative ATP binding site [chemical binding]; other site 290339000453 ADP-binding protein; Provisional; Region: PRK10646 290339000454 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 290339000455 AMIN domain; Region: AMIN; pfam11741 290339000456 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 290339000457 active site 290339000458 metal binding site [ion binding]; metal-binding site 290339000459 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 290339000460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290339000461 ATP binding site [chemical binding]; other site 290339000462 Mg2+ binding site [ion binding]; other site 290339000463 G-X-G motif; other site 290339000464 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 290339000465 ATP binding site [chemical binding]; other site 290339000466 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 290339000467 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 290339000468 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 290339000469 bacterial Hfq-like; Region: Hfq; cd01716 290339000470 hexamer interface [polypeptide binding]; other site 290339000471 Sm1 motif; other site 290339000472 RNA binding site [nucleotide binding]; other site 290339000473 Sm2 motif; other site 290339000474 GTPase HflX; Provisional; Region: PRK11058 290339000475 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 290339000476 HflX GTPase family; Region: HflX; cd01878 290339000477 G1 box; other site 290339000478 GTP/Mg2+ binding site [chemical binding]; other site 290339000479 Switch I region; other site 290339000480 G2 box; other site 290339000481 G3 box; other site 290339000482 Switch II region; other site 290339000483 G4 box; other site 290339000484 G5 box; other site 290339000485 FtsH protease regulator HflK; Provisional; Region: PRK10930 290339000486 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 290339000487 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 290339000488 FtsH protease regulator HflC; Provisional; Region: PRK11029 290339000489 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 290339000490 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 290339000491 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 290339000492 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 290339000493 GDP-binding site [chemical binding]; other site 290339000494 ACT binding site; other site 290339000495 IMP binding site; other site 290339000496 transcriptional repressor NsrR; Provisional; Region: PRK11014 290339000497 Predicted transcriptional regulator [Transcription]; Region: COG1959 290339000498 exoribonuclease R; Provisional; Region: PRK11642 290339000499 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 290339000500 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 290339000501 RNB domain; Region: RNB; pfam00773 290339000502 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 290339000503 RNA binding site [nucleotide binding]; other site 290339000504 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 290339000505 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 290339000506 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 290339000507 Predicted membrane protein [Function unknown]; Region: COG3766 290339000508 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 290339000509 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 290339000510 Protein of unknown function (DUF1190); Region: DUF1190; cl10031 290339000511 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 290339000512 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 290339000513 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 290339000514 active site 290339000515 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290339000516 dimerization interface [polypeptide binding]; other site 290339000517 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 290339000518 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 290339000519 dimer interface [polypeptide binding]; other site 290339000520 putative CheW interface [polypeptide binding]; other site 290339000521 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 290339000522 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 290339000523 esterase; Provisional; Region: PRK10566 290339000524 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 290339000525 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 290339000526 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 290339000527 dimer interface [polypeptide binding]; other site 290339000528 ssDNA binding site [nucleotide binding]; other site 290339000529 tetramer (dimer of dimers) interface [polypeptide binding]; other site 290339000530 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 290339000531 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 290339000532 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 290339000533 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 290339000534 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 290339000535 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 290339000536 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 290339000537 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 290339000538 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 290339000539 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 290339000540 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 290339000541 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 290339000542 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 290339000543 Hemerythrin-like domain; Region: Hr-like; cd12108 290339000544 Fe binding site [ion binding]; other site 290339000545 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 290339000546 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 290339000547 dimer interface [polypeptide binding]; other site 290339000548 ligand binding site [chemical binding]; other site 290339000549 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290339000550 dimerization interface [polypeptide binding]; other site 290339000551 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 290339000552 dimer interface [polypeptide binding]; other site 290339000553 putative CheW interface [polypeptide binding]; other site 290339000554 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 290339000555 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 290339000556 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 290339000557 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 290339000558 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290339000559 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 290339000560 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 290339000561 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 290339000562 NADP binding site [chemical binding]; other site 290339000563 Predicted transcriptional regulators [Transcription]; Region: COG1733 290339000564 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 290339000565 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 290339000566 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 290339000567 active site 290339000568 metal binding site [ion binding]; metal-binding site 290339000569 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 290339000570 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 290339000571 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 290339000572 active site 290339000573 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 290339000574 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 290339000575 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 290339000576 Domain of unknown function DUF21; Region: DUF21; pfam01595 290339000577 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 290339000578 Transporter associated domain; Region: CorC_HlyC; smart01091 290339000579 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 290339000580 methionine sulfoxide reductase A; Provisional; Region: PRK00058 290339000581 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 290339000582 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 290339000583 Surface antigen; Region: Bac_surface_Ag; pfam01103 290339000584 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 290339000585 Family of unknown function (DUF490); Region: DUF490; pfam04357 290339000586 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 290339000587 dimerization interface [polypeptide binding]; other site 290339000588 putative active site pocket [active] 290339000589 putative catalytic residue [active] 290339000590 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290339000591 dimerization interface [polypeptide binding]; other site 290339000592 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 290339000593 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 290339000594 dimer interface [polypeptide binding]; other site 290339000595 putative CheW interface [polypeptide binding]; other site 290339000596 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 290339000597 dimer interface [polypeptide binding]; other site 290339000598 substrate binding site [chemical binding]; other site 290339000599 metal binding sites [ion binding]; metal-binding site 290339000600 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 290339000601 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 290339000602 putative ligand binding site [chemical binding]; other site 290339000603 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 290339000604 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 290339000605 Walker A/P-loop; other site 290339000606 ATP binding site [chemical binding]; other site 290339000607 Q-loop/lid; other site 290339000608 ABC transporter signature motif; other site 290339000609 Walker B; other site 290339000610 D-loop; other site 290339000611 H-loop/switch region; other site 290339000612 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 290339000613 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290339000614 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290339000615 TM-ABC transporter signature motif; other site 290339000616 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290339000617 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290339000618 TM-ABC transporter signature motif; other site 290339000619 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 290339000620 dimer interface [polypeptide binding]; other site 290339000621 ligand binding site [chemical binding]; other site 290339000622 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 290339000623 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 290339000624 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 290339000625 dimer interface [polypeptide binding]; other site 290339000626 putative CheW interface [polypeptide binding]; other site 290339000627 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 290339000628 AMP binding site [chemical binding]; other site 290339000629 metal binding site [ion binding]; metal-binding site 290339000630 active site 290339000631 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 290339000632 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 290339000633 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 290339000634 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 290339000635 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 290339000636 active site 290339000637 catalytic residues [active] 290339000638 hypothetical protein; Provisional; Region: PRK05255 290339000639 peptidase PmbA; Provisional; Region: PRK11040 290339000640 cytochrome b562; Provisional; Region: PRK15058 290339000641 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 290339000642 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; cl11916 290339000643 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 290339000644 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 290339000645 Domain of unknown function (DUF4310); Region: DUF4310; pfam14187 290339000646 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290339000647 active site 290339000648 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290339000649 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 290339000650 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 290339000651 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 290339000652 HTH domain; Region: HTH_11; pfam08279 290339000653 Mga helix-turn-helix domain; Region: Mga; pfam05043 290339000654 PRD domain; Region: PRD; pfam00874 290339000655 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 290339000656 active site 290339000657 P-loop; other site 290339000658 phosphorylation site [posttranslational modification] 290339000659 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 290339000660 active site 290339000661 phosphorylation site [posttranslational modification] 290339000662 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 290339000663 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 290339000664 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 290339000665 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290339000666 FeS/SAM binding site; other site 290339000667 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 290339000668 ATP cone domain; Region: ATP-cone; pfam03477 290339000669 Class III ribonucleotide reductase; Region: RNR_III; cd01675 290339000670 effector binding site; other site 290339000671 active site 290339000672 Zn binding site [ion binding]; other site 290339000673 glycine loop; other site 290339000674 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 290339000675 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339000676 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 290339000677 putative effector binding pocket; other site 290339000678 dimerization interface [polypeptide binding]; other site 290339000679 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 290339000680 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 290339000681 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 290339000682 Ca binding site [ion binding]; other site 290339000683 active site 290339000684 catalytic site [active] 290339000685 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 290339000686 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 290339000687 active site turn [active] 290339000688 phosphorylation site [posttranslational modification] 290339000689 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 290339000690 trehalose repressor; Provisional; Region: treR; PRK09492 290339000691 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290339000692 DNA binding site [nucleotide binding] 290339000693 domain linker motif; other site 290339000694 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 290339000695 dimerization interface [polypeptide binding]; other site 290339000696 ligand binding site [chemical binding]; other site 290339000697 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290339000698 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290339000699 glutaredoxin 2; Provisional; Region: PRK10387 290339000700 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 290339000701 C-terminal domain interface [polypeptide binding]; other site 290339000702 GSH binding site (G-site) [chemical binding]; other site 290339000703 catalytic residues [active] 290339000704 putative dimer interface [polypeptide binding]; other site 290339000705 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 290339000706 N-terminal domain interface [polypeptide binding]; other site 290339000707 Uncharacterized conserved protein [Function unknown]; Region: COG1359 290339000708 lipoprotein LpqB; Provisional; Region: PRK13616 290339000709 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290339000710 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290339000711 active site 290339000712 catalytic tetrad [active] 290339000713 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 290339000714 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 290339000715 dimer interface [polypeptide binding]; other site 290339000716 active site 290339000717 metal binding site [ion binding]; metal-binding site 290339000718 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 290339000719 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290339000720 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 290339000721 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290339000722 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 290339000723 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 290339000724 biopolymer transport protein ExbB; Provisional; Region: PRK10414 290339000725 biopolymer transport protein ExbD; Provisional; Region: PRK11267 290339000726 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 290339000727 oxidoreductase; Provisional; Region: PRK07985 290339000728 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 290339000729 NAD binding site [chemical binding]; other site 290339000730 metal binding site [ion binding]; metal-binding site 290339000731 active site 290339000732 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 290339000733 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 290339000734 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 290339000735 hypothetical protein; Provisional; Region: PRK05208 290339000736 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 290339000737 Mechanosensitive ion channel; Region: MS_channel; pfam00924 290339000738 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 290339000739 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 290339000740 methionine cluster; other site 290339000741 active site 290339000742 phosphorylation site [posttranslational modification] 290339000743 metal binding site [ion binding]; metal-binding site 290339000744 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 290339000745 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 290339000746 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 290339000747 active site 290339000748 P-loop; other site 290339000749 phosphorylation site [posttranslational modification] 290339000750 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290339000751 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290339000752 DNA binding site [nucleotide binding] 290339000753 domain linker motif; other site 290339000754 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290339000755 ligand binding site [chemical binding]; other site 290339000756 Predicted membrane protein (DUF2238); Region: DUF2238; cl01464 290339000757 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 290339000758 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 290339000759 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 290339000760 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 290339000761 Peptidase family M23; Region: Peptidase_M23; pfam01551 290339000762 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 290339000763 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 290339000764 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 290339000765 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 290339000766 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 290339000767 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 290339000768 active site 290339000769 catalytic triad [active] 290339000770 oxyanion hole [active] 290339000771 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 290339000772 SGNH_peri1; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri1; cd01825 290339000773 active site 290339000774 oxyanion hole [active] 290339000775 catalytic triad [active] 290339000776 hypothetical protein; Provisional; Region: PRK11410 290339000777 Protein of unknown function (DUF1175); Region: DUF1175; cl14898 290339000778 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 290339000779 MG2 domain; Region: A2M_N; pfam01835 290339000780 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 290339000781 Alpha-2-macroglobulin family; Region: A2M; pfam00207 290339000782 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 290339000783 Predicted secreted protein [Function unknown]; Region: COG5445 290339000784 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 290339000785 Predicted secreted protein [Function unknown]; Region: COG5445 290339000786 Stage II sporulation protein; Region: SpoIID; pfam08486 290339000787 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 290339000788 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 290339000789 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 290339000790 Protein of unknown function (DUF554); Region: DUF554; pfam04474 290339000791 ornithine decarboxylase; Provisional; Region: PRK13578 290339000792 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 290339000793 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 290339000794 homodimer interface [polypeptide binding]; other site 290339000795 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339000796 catalytic residue [active] 290339000797 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 290339000798 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 290339000799 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290339000800 active site 290339000801 phosphorylation site [posttranslational modification] 290339000802 intermolecular recognition site; other site 290339000803 dimerization interface [polypeptide binding]; other site 290339000804 Transcriptional regulator; Region: CitT; pfam12431 290339000805 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 290339000806 PAS domain; Region: PAS; smart00091 290339000807 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290339000808 ATP binding site [chemical binding]; other site 290339000809 Mg2+ binding site [ion binding]; other site 290339000810 G-X-G motif; other site 290339000811 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 290339000812 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 290339000813 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 290339000814 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 290339000815 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 290339000816 putative active site [active] 290339000817 (T/H)XGH motif; other site 290339000818 citrate lyase subunit gamma; Provisional; Region: PRK13253 290339000819 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 290339000820 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 290339000821 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 290339000822 Coenzyme A transferase; Region: CoA_trans; cl17247 290339000823 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 290339000824 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 290339000825 murein transglycosylase C; Provisional; Region: mltC; PRK11671 290339000826 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 290339000827 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 290339000828 N-acetyl-D-glucosamine binding site [chemical binding]; other site 290339000829 catalytic residue [active] 290339000830 oxidative damage protection protein; Provisional; Region: PRK05408 290339000831 adenine DNA glycosylase; Provisional; Region: PRK10880 290339000832 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 290339000833 minor groove reading motif; other site 290339000834 helix-hairpin-helix signature motif; other site 290339000835 substrate binding pocket [chemical binding]; other site 290339000836 active site 290339000837 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 290339000838 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 290339000839 DNA binding and oxoG recognition site [nucleotide binding] 290339000840 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 290339000841 hypothetical protein; Provisional; Region: PRK11702 290339000842 hypothetical protein; Provisional; Region: PRK10626 290339000843 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 290339000844 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 290339000845 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 290339000846 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 290339000847 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 290339000848 Uncharacterized small protein [Function unknown]; Region: COG2879 290339000849 carbon starvation protein A; Provisional; Region: PRK15015 290339000850 Carbon starvation protein CstA; Region: CstA; pfam02554 290339000851 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 290339000852 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 290339000853 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290339000854 dimerization interface [polypeptide binding]; other site 290339000855 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 290339000856 dimer interface [polypeptide binding]; other site 290339000857 putative CheW interface [polypeptide binding]; other site 290339000858 beta-carotene hydroxylase; Region: PLN02601 290339000859 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 290339000860 active site lid residues [active] 290339000861 substrate binding pocket [chemical binding]; other site 290339000862 catalytic residues [active] 290339000863 substrate-Mg2+ binding site; other site 290339000864 aspartate-rich region 1; other site 290339000865 aspartate-rich region 2; other site 290339000866 phytoene desaturase; Region: crtI_fam; TIGR02734 290339000867 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 290339000868 Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834 290339000869 lycopene cyclase; Region: lycopene_cycl; TIGR01789 290339000870 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 290339000871 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 290339000872 active site 290339000873 TDP-binding site; other site 290339000874 acceptor substrate-binding pocket; other site 290339000875 homodimer interface [polypeptide binding]; other site 290339000876 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 290339000877 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 290339000878 homotetramer interface [polypeptide binding]; other site 290339000879 FMN binding site [chemical binding]; other site 290339000880 homodimer contacts [polypeptide binding]; other site 290339000881 putative active site [active] 290339000882 putative substrate binding site [chemical binding]; other site 290339000883 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 290339000884 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 290339000885 substrate binding pocket [chemical binding]; other site 290339000886 chain length determination region; other site 290339000887 substrate-Mg2+ binding site; other site 290339000888 catalytic residues [active] 290339000889 aspartate-rich region 1; other site 290339000890 active site lid residues [active] 290339000891 aspartate-rich region 2; other site 290339000892 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 290339000893 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 290339000894 active site 290339000895 SUMO-1 interface [polypeptide binding]; other site 290339000896 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 290339000897 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 290339000898 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 290339000899 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 290339000900 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290339000901 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 290339000902 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290339000903 DNA binding residues [nucleotide binding] 290339000904 DNA primase; Validated; Region: dnaG; PRK05667 290339000905 CHC2 zinc finger; Region: zf-CHC2; pfam01807 290339000906 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 290339000907 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 290339000908 active site 290339000909 metal binding site [ion binding]; metal-binding site 290339000910 interdomain interaction site; other site 290339000911 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 290339000912 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 290339000913 UGMP family protein; Validated; Region: PRK09604 290339000914 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 290339000915 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 290339000916 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 290339000917 homooctamer interface [polypeptide binding]; other site 290339000918 active site 290339000919 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 290339000920 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 290339000921 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 290339000922 active site 290339000923 NTP binding site [chemical binding]; other site 290339000924 metal binding triad [ion binding]; metal-binding site 290339000925 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 290339000926 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 290339000927 Zn2+ binding site [ion binding]; other site 290339000928 Mg2+ binding site [ion binding]; other site 290339000929 SH3 domain-containing protein; Provisional; Region: PRK10884 290339000930 Bacterial SH3 domain homologues; Region: SH3b; smart00287 290339000931 Uncharacterized conserved protein [Function unknown]; Region: COG3025 290339000932 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 290339000933 putative active site [active] 290339000934 putative metal binding residues [ion binding]; other site 290339000935 signature motif; other site 290339000936 putative triphosphate binding site [ion binding]; other site 290339000937 CHAD domain; Region: CHAD; pfam05235 290339000938 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 290339000939 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 290339000940 metal binding triad; other site 290339000941 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 290339000942 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 290339000943 metal binding triad; other site 290339000944 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 290339000945 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 290339000946 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 290339000947 putative ribose interaction site [chemical binding]; other site 290339000948 putative ADP binding site [chemical binding]; other site 290339000949 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 290339000950 active site 290339000951 nucleotide binding site [chemical binding]; other site 290339000952 HIGH motif; other site 290339000953 KMSKS motif; other site 290339000954 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 290339000955 FMN riboswitch (RFN element) 290339000956 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 290339000957 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 290339000958 zinc transporter ZupT; Provisional; Region: PRK04201 290339000959 ZIP Zinc transporter; Region: Zip; pfam02535 290339000960 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 290339000961 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 290339000962 putative active site [active] 290339000963 metal binding site [ion binding]; metal-binding site 290339000964 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 290339000965 hypothetical protein; Provisional; Region: PRK11653 290339000966 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 290339000967 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 290339000968 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 290339000969 dimer interface [polypeptide binding]; other site 290339000970 ADP-ribose binding site [chemical binding]; other site 290339000971 active site 290339000972 nudix motif; other site 290339000973 metal binding site [ion binding]; metal-binding site 290339000974 putative dehydrogenase; Provisional; Region: PRK11039 290339000975 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 290339000976 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 290339000977 active site 290339000978 metal binding site [ion binding]; metal-binding site 290339000979 hexamer interface [polypeptide binding]; other site 290339000980 esterase YqiA; Provisional; Region: PRK11071 290339000981 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 290339000982 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 290339000983 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290339000984 ATP binding site [chemical binding]; other site 290339000985 Mg2+ binding site [ion binding]; other site 290339000986 G-X-G motif; other site 290339000987 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 290339000988 anchoring element; other site 290339000989 dimer interface [polypeptide binding]; other site 290339000990 ATP binding site [chemical binding]; other site 290339000991 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 290339000992 active site 290339000993 metal binding site [ion binding]; metal-binding site 290339000994 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 290339000995 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 290339000996 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 290339000997 heme binding site [chemical binding]; other site 290339000998 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 290339000999 Uncharacterized conserved protein [Function unknown]; Region: COG1359 290339001000 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 290339001001 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 290339001002 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 290339001003 CAP-like domain; other site 290339001004 active site 290339001005 primary dimer interface [polypeptide binding]; other site 290339001006 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 290339001007 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 290339001008 putative acyl-acceptor binding pocket; other site 290339001009 FtsI repressor; Provisional; Region: PRK10883 290339001010 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 290339001011 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 290339001012 HemN family oxidoreductase; Provisional; Region: PRK05660 290339001013 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290339001014 FeS/SAM binding site; other site 290339001015 HemN C-terminal domain; Region: HemN_C; pfam06969 290339001016 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 290339001017 active site 290339001018 dimerization interface [polypeptide binding]; other site 290339001019 hypothetical protein; Validated; Region: PRK05090 290339001020 YGGT family; Region: YGGT; pfam02325 290339001021 Predicted integral membrane protein [Function unknown]; Region: COG0762 290339001022 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 290339001023 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 290339001024 catalytic residue [active] 290339001025 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 290339001026 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 290339001027 Walker A motif; other site 290339001028 ATP binding site [chemical binding]; other site 290339001029 Walker B motif; other site 290339001030 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 290339001031 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 290339001032 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290339001033 Bacterial transcriptional regulator; Region: IclR; pfam01614 290339001034 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 290339001035 hypothetical protein; Validated; Region: PRK00228 290339001036 glutathione synthetase; Provisional; Region: PRK05246 290339001037 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 290339001038 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 290339001039 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 290339001040 RNA methyltransferase, RsmE family; Region: TIGR00046 290339001041 DNA-specific endonuclease I; Provisional; Region: PRK15137 290339001042 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 290339001043 hypothetical protein; Provisional; Region: PRK04860 290339001044 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 290339001045 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 290339001046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339001047 putative substrate translocation pore; other site 290339001048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339001049 S-adenosylmethionine synthetase; Validated; Region: PRK05250 290339001050 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 290339001051 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 290339001052 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 290339001053 arginine decarboxylase; Provisional; Region: PRK05354 290339001054 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 290339001055 dimer interface [polypeptide binding]; other site 290339001056 active site 290339001057 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 290339001058 catalytic residues [active] 290339001059 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 290339001060 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 290339001061 agmatinase; Region: agmatinase; TIGR01230 290339001062 oligomer interface [polypeptide binding]; other site 290339001063 putative active site [active] 290339001064 Mn binding site [ion binding]; other site 290339001065 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 290339001066 transketolase; Reviewed; Region: PRK12753 290339001067 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 290339001068 TPP-binding site [chemical binding]; other site 290339001069 dimer interface [polypeptide binding]; other site 290339001070 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 290339001071 PYR/PP interface [polypeptide binding]; other site 290339001072 dimer interface [polypeptide binding]; other site 290339001073 TPP binding site [chemical binding]; other site 290339001074 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 290339001075 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 290339001076 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 290339001077 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 290339001078 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 290339001079 Phosphoglycerate kinase; Region: PGK; pfam00162 290339001080 substrate binding site [chemical binding]; other site 290339001081 hinge regions; other site 290339001082 ADP binding site [chemical binding]; other site 290339001083 catalytic site [active] 290339001084 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 290339001085 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 290339001086 active site 290339001087 intersubunit interface [polypeptide binding]; other site 290339001088 zinc binding site [ion binding]; other site 290339001089 Na+ binding site [ion binding]; other site 290339001090 mechanosensitive channel MscS; Provisional; Region: PRK10334 290339001091 Mechanosensitive ion channel; Region: MS_channel; pfam00924 290339001092 arginine exporter protein; Provisional; Region: PRK09304 290339001093 Uncharacterized conserved protein [Function unknown]; Region: COG2968 290339001094 oxidative stress defense protein; Provisional; Region: PRK11087 290339001095 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 290339001096 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339001097 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 290339001098 putative dimerization interface [polypeptide binding]; other site 290339001099 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 290339001100 tetramer (dimer of dimers) interface [polypeptide binding]; other site 290339001101 active site 290339001102 dimer interface [polypeptide binding]; other site 290339001103 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 290339001104 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 290339001105 ligand binding site [chemical binding]; other site 290339001106 NAD binding site [chemical binding]; other site 290339001107 tetramer interface [polypeptide binding]; other site 290339001108 catalytic site [active] 290339001109 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 290339001110 L-serine binding site [chemical binding]; other site 290339001111 ACT domain interface; other site 290339001112 Z-ring-associated protein; Provisional; Region: PRK10972 290339001113 hypothetical protein; Reviewed; Region: PRK01736 290339001114 proline aminopeptidase P II; Provisional; Region: PRK10879 290339001115 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 290339001116 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 290339001117 active site 290339001118 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 290339001119 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 290339001120 oxidoreductase; Provisional; Region: PRK08013 290339001121 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 290339001122 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 290339001123 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 290339001124 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 290339001125 lipoyl attachment site [posttranslational modification]; other site 290339001126 glycine dehydrogenase; Provisional; Region: PRK05367 290339001127 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 290339001128 tetramer interface [polypeptide binding]; other site 290339001129 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339001130 catalytic residue [active] 290339001131 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 290339001132 tetramer interface [polypeptide binding]; other site 290339001133 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339001134 catalytic residue [active] 290339001135 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 290339001136 classical (c) SDRs; Region: SDR_c; cd05233 290339001137 NAD(P) binding site [chemical binding]; other site 290339001138 active site 290339001139 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 290339001140 beta-galactosidase; Region: BGL; TIGR03356 290339001141 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 290339001142 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 290339001143 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 290339001144 putative active site [active] 290339001145 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 290339001146 hemolysin; Provisional; Region: PRK15087 290339001147 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 290339001148 putative global regulator; Reviewed; Region: PRK09559 290339001149 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 290339001150 hypothetical protein; Provisional; Region: PRK10878 290339001151 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 290339001152 flavodoxin FldB; Provisional; Region: PRK12359 290339001153 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 290339001154 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 290339001155 active site 290339001156 Int/Topo IB signature motif; other site 290339001157 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 290339001158 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 290339001159 dimerization domain [polypeptide binding]; other site 290339001160 dimer interface [polypeptide binding]; other site 290339001161 catalytic residues [active] 290339001162 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 290339001163 DHH family; Region: DHH; pfam01368 290339001164 DHHA1 domain; Region: DHHA1; pfam02272 290339001165 This domain is found in peptide chain release factors; Region: PCRF; smart00937 290339001166 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 290339001167 RF-1 domain; Region: RF-1; pfam00472 290339001168 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 290339001169 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 290339001170 dimer interface [polypeptide binding]; other site 290339001171 putative anticodon binding site; other site 290339001172 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 290339001173 motif 1; other site 290339001174 active site 290339001175 motif 2; other site 290339001176 motif 3; other site 290339001177 Peptidase family M23; Region: Peptidase_M23; pfam01551 290339001178 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 290339001179 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 290339001180 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 290339001181 ligand binding site [chemical binding]; other site 290339001182 flexible hinge region; other site 290339001183 Transcriptional regulator; Region: Rrf2; cl17282 290339001184 putative acyltransferase; Provisional; Region: PRK05790 290339001185 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 290339001186 dimer interface [polypeptide binding]; other site 290339001187 active site 290339001188 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 290339001189 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 290339001190 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 290339001191 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 290339001192 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 290339001193 NADP binding site [chemical binding]; other site 290339001194 homodimer interface [polypeptide binding]; other site 290339001195 active site 290339001196 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290339001197 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290339001198 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 290339001199 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290339001200 Walker B; other site 290339001201 D-loop; other site 290339001202 H-loop/switch region; other site 290339001203 TOBE domain; Region: TOBE; pfam03459 290339001204 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290339001205 Walker A/P-loop; other site 290339001206 ATP binding site [chemical binding]; other site 290339001207 Q-loop/lid; other site 290339001208 ABC transporter signature motif; other site 290339001209 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290339001210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339001211 dimer interface [polypeptide binding]; other site 290339001212 conserved gate region; other site 290339001213 putative PBP binding loops; other site 290339001214 ABC-ATPase subunit interface; other site 290339001215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339001216 dimer interface [polypeptide binding]; other site 290339001217 conserved gate region; other site 290339001218 putative PBP binding loops; other site 290339001219 ABC-ATPase subunit interface; other site 290339001220 LPS O-antigen length regulator; Provisional; Region: PRK10381 290339001221 Chain length determinant protein; Region: Wzz; pfam02706 290339001222 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 290339001223 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 290339001224 aspartate racemase; Region: asp_race; TIGR00035 290339001225 putative racemase; Provisional; Region: PRK10200 290339001226 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 290339001227 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339001228 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290339001229 dimerization interface [polypeptide binding]; other site 290339001230 diaminopimelate decarboxylase; Provisional; Region: PRK11165 290339001231 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 290339001232 active site 290339001233 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 290339001234 substrate binding site [chemical binding]; other site 290339001235 catalytic residues [active] 290339001236 dimer interface [polypeptide binding]; other site 290339001237 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290339001238 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290339001239 DNA binding site [nucleotide binding] 290339001240 domain linker motif; other site 290339001241 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 290339001242 dimerization interface (closed form) [polypeptide binding]; other site 290339001243 ligand binding site [chemical binding]; other site 290339001244 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 290339001245 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 290339001246 beta-galactosidase; Region: BGL; TIGR03356 290339001247 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 290339001248 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 290339001249 active site 290339001250 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 290339001251 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290339001252 DNA-binding site [nucleotide binding]; DNA binding site 290339001253 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 290339001254 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290339001255 Coenzyme A binding pocket [chemical binding]; other site 290339001256 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 290339001257 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290339001258 DNA binding site [nucleotide binding] 290339001259 domain linker motif; other site 290339001260 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 290339001261 dimerization interface (closed form) [polypeptide binding]; other site 290339001262 ligand binding site [chemical binding]; other site 290339001263 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 290339001264 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 290339001265 putative acyl-acceptor binding pocket; other site 290339001266 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 290339001267 acyl-activating enzyme (AAE) consensus motif; other site 290339001268 putative AMP binding site [chemical binding]; other site 290339001269 lysophospholipid transporter LplT; Provisional; Region: PRK11195 290339001270 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339001271 putative substrate translocation pore; other site 290339001272 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290339001273 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290339001274 active site 290339001275 catalytic tetrad [active] 290339001276 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 290339001277 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 290339001278 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 290339001279 putative DNA-binding cleft [nucleotide binding]; other site 290339001280 putative DNA clevage site; other site 290339001281 molecular lever; other site 290339001282 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 290339001283 putative active site [active] 290339001284 Ap4A binding site [chemical binding]; other site 290339001285 nudix motif; other site 290339001286 putative metal binding site [ion binding]; other site 290339001287 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 290339001288 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 290339001289 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 290339001290 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 290339001291 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 290339001292 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 290339001293 thymidylate synthase; Reviewed; Region: thyA; PRK01827 290339001294 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 290339001295 dimerization interface [polypeptide binding]; other site 290339001296 active site 290339001297 hypothetical protein; Provisional; Region: PRK10506 290339001298 hypothetical protein; Provisional; Region: PRK10557 290339001299 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 290339001300 Protein of unknown function (DUF2509); Region: DUF2509; pfam10713 290339001301 hypothetical protein; Provisional; Region: PRK10332 290339001302 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 290339001303 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 290339001304 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 290339001305 protease3; Provisional; Region: PRK15101 290339001306 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 290339001307 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 290339001308 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 290339001309 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 290339001310 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 290339001311 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 290339001312 AAA domain; Region: AAA_30; pfam13604 290339001313 Family description; Region: UvrD_C_2; pfam13538 290339001314 N-acetylglutamate synthase; Validated; Region: PRK05279 290339001315 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 290339001316 putative nucleotide binding site [chemical binding]; other site 290339001317 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290339001318 Coenzyme A binding pocket [chemical binding]; other site 290339001319 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 290339001320 AMIN domain; Region: AMIN; pfam11741 290339001321 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 290339001322 active site 290339001323 metal binding site [ion binding]; metal-binding site 290339001324 murein transglycosylase A; Provisional; Region: mltA; PRK11162 290339001325 MltA specific insert domain; Region: MltA; pfam03562 290339001326 3D domain; Region: 3D; pfam06725 290339001327 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 290339001328 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 290339001329 putative ATP binding site [chemical binding]; other site 290339001330 putative substrate interface [chemical binding]; other site 290339001331 Fe-S metabolism associated domain; Region: SufE; cl00951 290339001332 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 290339001333 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 290339001334 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290339001335 catalytic residue [active] 290339001336 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 290339001337 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 290339001338 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339001339 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 290339001340 dimerization interface [polypeptide binding]; other site 290339001341 substrate binding pocket [chemical binding]; other site 290339001342 hypothetical protein; Provisional; Region: PRK10873 290339001343 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 290339001344 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 290339001345 flap endonuclease-like protein; Provisional; Region: PRK09482 290339001346 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 290339001347 active site 290339001348 metal binding site 1 [ion binding]; metal-binding site 290339001349 putative 5' ssDNA interaction site; other site 290339001350 metal binding site 3; metal-binding site 290339001351 metal binding site 2 [ion binding]; metal-binding site 290339001352 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 290339001353 putative DNA binding site [nucleotide binding]; other site 290339001354 putative metal binding site [ion binding]; other site 290339001355 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 290339001356 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 290339001357 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 290339001358 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 290339001359 serine transporter; Region: stp; TIGR00814 290339001360 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 290339001361 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 290339001362 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 290339001363 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 290339001364 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 290339001365 SecY interacting protein Syd; Provisional; Region: PRK04968 290339001366 tRNA pseudouridine synthase C; Region: DUF446; cl01187 290339001367 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 290339001368 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 290339001369 probable active site [active] 290339001370 flavodoxin; Provisional; Region: PRK08105 290339001371 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 290339001372 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 290339001373 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290339001374 dimerization interface [polypeptide binding]; other site 290339001375 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290339001376 dimer interface [polypeptide binding]; other site 290339001377 phosphorylation site [posttranslational modification] 290339001378 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290339001379 ATP binding site [chemical binding]; other site 290339001380 Mg2+ binding site [ion binding]; other site 290339001381 G-X-G motif; other site 290339001382 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 290339001383 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290339001384 active site 290339001385 phosphorylation site [posttranslational modification] 290339001386 intermolecular recognition site; other site 290339001387 dimerization interface [polypeptide binding]; other site 290339001388 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 290339001389 putative binding surface; other site 290339001390 active site 290339001391 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 290339001392 TRAM domain; Region: TRAM; pfam01938 290339001393 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 290339001394 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290339001395 S-adenosylmethionine binding site [chemical binding]; other site 290339001396 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 290339001397 HD domain; Region: HD_4; pfam13328 290339001398 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 290339001399 synthetase active site [active] 290339001400 NTP binding site [chemical binding]; other site 290339001401 metal binding site [ion binding]; metal-binding site 290339001402 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 290339001403 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 290339001404 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 290339001405 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 290339001406 homodimer interface [polypeptide binding]; other site 290339001407 metal binding site [ion binding]; metal-binding site 290339001408 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 290339001409 homodimer interface [polypeptide binding]; other site 290339001410 active site 290339001411 putative chemical substrate binding site [chemical binding]; other site 290339001412 metal binding site [ion binding]; metal-binding site 290339001413 CTP synthetase; Validated; Region: pyrG; PRK05380 290339001414 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 290339001415 Catalytic site [active] 290339001416 active site 290339001417 UTP binding site [chemical binding]; other site 290339001418 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 290339001419 active site 290339001420 putative oxyanion hole; other site 290339001421 catalytic triad [active] 290339001422 enolase; Provisional; Region: eno; PRK00077 290339001423 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 290339001424 dimer interface [polypeptide binding]; other site 290339001425 metal binding site [ion binding]; metal-binding site 290339001426 substrate binding pocket [chemical binding]; other site 290339001427 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290339001428 NAD(P) binding site [chemical binding]; other site 290339001429 active site 290339001430 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 290339001431 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 290339001432 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 290339001433 putative active site [active] 290339001434 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 290339001435 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 290339001436 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 290339001437 active site turn [active] 290339001438 phosphorylation site [posttranslational modification] 290339001439 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 290339001440 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 290339001441 putative active site cavity [active] 290339001442 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 290339001443 Repair protein; Region: Repair_PSII; pfam04536 290339001444 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 290339001445 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 290339001446 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 290339001447 active site 290339001448 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 290339001449 Flavodoxin; Region: Flavodoxin_1; pfam00258 290339001450 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 290339001451 FAD binding pocket [chemical binding]; other site 290339001452 FAD binding motif [chemical binding]; other site 290339001453 catalytic residues [active] 290339001454 NAD binding pocket [chemical binding]; other site 290339001455 phosphate binding motif [ion binding]; other site 290339001456 beta-alpha-beta structure motif; other site 290339001457 sulfite reductase subunit beta; Provisional; Region: PRK13504 290339001458 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 290339001459 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 290339001460 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 290339001461 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 290339001462 Active Sites [active] 290339001463 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 290339001464 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 290339001465 metal binding site [ion binding]; metal-binding site 290339001466 siroheme synthase; Provisional; Region: cysG; PRK10637 290339001467 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 290339001468 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 290339001469 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 290339001470 active site 290339001471 SAM binding site [chemical binding]; other site 290339001472 homodimer interface [polypeptide binding]; other site 290339001473 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 290339001474 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 290339001475 Active Sites [active] 290339001476 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 290339001477 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 290339001478 CysD dimerization site [polypeptide binding]; other site 290339001479 G1 box; other site 290339001480 putative GEF interaction site [polypeptide binding]; other site 290339001481 GTP/Mg2+ binding site [chemical binding]; other site 290339001482 Switch I region; other site 290339001483 G2 box; other site 290339001484 G3 box; other site 290339001485 Switch II region; other site 290339001486 G4 box; other site 290339001487 G5 box; other site 290339001488 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 290339001489 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 290339001490 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 290339001491 ligand-binding site [chemical binding]; other site 290339001492 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 290339001493 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 290339001494 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 290339001495 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 290339001496 substrate binding site; other site 290339001497 dimer interface; other site 290339001498 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 290339001499 homotrimer interaction site [polypeptide binding]; other site 290339001500 zinc binding site [ion binding]; other site 290339001501 CDP-binding sites; other site 290339001502 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 290339001503 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 290339001504 Permutation of conserved domain; other site 290339001505 active site 290339001506 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 290339001507 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 290339001508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290339001509 S-adenosylmethionine binding site [chemical binding]; other site 290339001510 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 290339001511 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 290339001512 Peptidase family M23; Region: Peptidase_M23; pfam01551 290339001513 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 290339001514 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339001515 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290339001516 putative substrate translocation pore; other site 290339001517 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290339001518 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339001519 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 290339001520 putative effector binding pocket; other site 290339001521 dimerization interface [polypeptide binding]; other site 290339001522 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 290339001523 MarR family; Region: MarR_2; cl17246 290339001524 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 290339001525 Flavoprotein; Region: Flavoprotein; pfam02441 290339001526 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 290339001527 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 290339001528 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 290339001529 MutS domain I; Region: MutS_I; pfam01624 290339001530 MutS domain II; Region: MutS_II; pfam05188 290339001531 MutS domain III; Region: MutS_III; pfam05192 290339001532 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 290339001533 Walker A/P-loop; other site 290339001534 ATP binding site [chemical binding]; other site 290339001535 Q-loop/lid; other site 290339001536 ABC transporter signature motif; other site 290339001537 Walker B; other site 290339001538 D-loop; other site 290339001539 H-loop/switch region; other site 290339001540 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 290339001541 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 290339001542 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 290339001543 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 290339001544 dimer interface [polypeptide binding]; other site 290339001545 ligand binding site [chemical binding]; other site 290339001546 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 290339001547 dimerization interface [polypeptide binding]; other site 290339001548 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 290339001549 dimer interface [polypeptide binding]; other site 290339001550 putative CheW interface [polypeptide binding]; other site 290339001551 KTSC domain; Region: KTSC; pfam13619 290339001552 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290339001553 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 290339001554 substrate binding pocket [chemical binding]; other site 290339001555 membrane-bound complex binding site; other site 290339001556 hinge residues; other site 290339001557 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 290339001558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339001559 dimer interface [polypeptide binding]; other site 290339001560 conserved gate region; other site 290339001561 putative PBP binding loops; other site 290339001562 ABC-ATPase subunit interface; other site 290339001563 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 290339001564 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 290339001565 Walker A/P-loop; other site 290339001566 ATP binding site [chemical binding]; other site 290339001567 Q-loop/lid; other site 290339001568 ABC transporter signature motif; other site 290339001569 Walker B; other site 290339001570 D-loop; other site 290339001571 H-loop/switch region; other site 290339001572 Transglycosylase SLT domain; Region: SLT_2; pfam13406 290339001573 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 290339001574 N-acetyl-D-glucosamine binding site [chemical binding]; other site 290339001575 hypothetical protein; Validated; Region: PRK03661 290339001576 recombinase A; Provisional; Region: recA; PRK09354 290339001577 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 290339001578 hexamer interface [polypeptide binding]; other site 290339001579 Walker A motif; other site 290339001580 ATP binding site [chemical binding]; other site 290339001581 Walker B motif; other site 290339001582 recombination regulator RecX; Reviewed; Region: recX; PRK00117 290339001583 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 290339001584 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 290339001585 motif 1; other site 290339001586 active site 290339001587 motif 2; other site 290339001588 motif 3; other site 290339001589 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 290339001590 DHHA1 domain; Region: DHHA1; pfam02272 290339001591 carbon storage regulator; Provisional; Region: PRK01712 290339001592 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 290339001593 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290339001594 motif II; other site 290339001595 Predicted membrane protein [Function unknown]; Region: COG1238 290339001596 glutamate--cysteine ligase; Provisional; Region: PRK02107 290339001597 S-ribosylhomocysteinase; Provisional; Region: PRK02260 290339001598 CHASE4 domain; Region: CHASE4; pfam05228 290339001599 PAS domain S-box; Region: sensory_box; TIGR00229 290339001600 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290339001601 putative active site [active] 290339001602 heme pocket [chemical binding]; other site 290339001603 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 290339001604 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290339001605 metal binding site [ion binding]; metal-binding site 290339001606 active site 290339001607 I-site; other site 290339001608 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290339001609 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 290339001610 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339001611 putative substrate translocation pore; other site 290339001612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339001613 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 290339001614 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 290339001615 HlyD family secretion protein; Region: HlyD_3; pfam13437 290339001616 transcriptional repressor MprA; Provisional; Region: PRK10870 290339001617 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 290339001618 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 290339001619 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339001620 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 290339001621 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 290339001622 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 290339001623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339001624 dimer interface [polypeptide binding]; other site 290339001625 conserved gate region; other site 290339001626 putative PBP binding loops; other site 290339001627 ABC-ATPase subunit interface; other site 290339001628 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 290339001629 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 290339001630 Walker A/P-loop; other site 290339001631 ATP binding site [chemical binding]; other site 290339001632 Q-loop/lid; other site 290339001633 ABC transporter signature motif; other site 290339001634 Walker B; other site 290339001635 D-loop; other site 290339001636 H-loop/switch region; other site 290339001637 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 290339001638 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 290339001639 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 290339001640 dimer interface [polypeptide binding]; other site 290339001641 putative radical transfer pathway; other site 290339001642 diiron center [ion binding]; other site 290339001643 tyrosyl radical; other site 290339001644 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 290339001645 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 290339001646 Class I ribonucleotide reductase; Region: RNR_I; cd01679 290339001647 active site 290339001648 dimer interface [polypeptide binding]; other site 290339001649 catalytic residues [active] 290339001650 effector binding site; other site 290339001651 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 290339001652 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 290339001653 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 290339001654 catalytic residues [active] 290339001655 hypothetical protein; Provisional; Region: PRK10132 290339001656 hypothetical protein; Provisional; Region: PRK10556 290339001657 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 290339001658 SAM (Sterile alpha motif ); Region: SAM_superfamily; cl15755 290339001659 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 290339001660 FIST N domain; Region: FIST; smart00897 290339001661 FIST C domain; Region: FIST_C; pfam10442 290339001662 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 290339001663 dimer interface [polypeptide binding]; other site 290339001664 putative CheW interface [polypeptide binding]; other site 290339001665 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 290339001666 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 290339001667 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 290339001668 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290339001669 ATP binding site [chemical binding]; other site 290339001670 putative Mg++ binding site [ion binding]; other site 290339001671 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290339001672 nucleotide binding region [chemical binding]; other site 290339001673 ATP-binding site [chemical binding]; other site 290339001674 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 290339001675 ligand binding site [chemical binding]; other site 290339001676 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 290339001677 HsdM N-terminal domain; Region: HsdM_N; pfam12161 290339001678 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 290339001679 Methyltransferase domain; Region: Methyltransf_26; pfam13659 290339001680 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 290339001681 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 290339001682 Domain of unknown function (DUF4268); Region: DUF4268; pfam14088 290339001683 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 290339001684 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 290339001685 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290339001686 ATP binding site [chemical binding]; other site 290339001687 putative Mg++ binding site [ion binding]; other site 290339001688 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 290339001689 AAA domain; Region: AAA_21; pfam13304 290339001690 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 290339001691 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 290339001692 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 290339001693 active site 290339001694 metal binding site [ion binding]; metal-binding site 290339001695 interdomain interaction site; other site 290339001696 D5 N terminal like; Region: D5_N; smart00885 290339001697 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 290339001698 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 290339001699 Ash protein family; Region: Phage_ASH; pfam10554 290339001700 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 290339001701 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 290339001702 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 290339001703 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 290339001704 AAA domain; Region: AAA_21; pfam13304 290339001705 integrase; Provisional; Region: PRK09692 290339001706 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 290339001707 active site 290339001708 Int/Topo IB signature motif; other site 290339001709 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 290339001710 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 290339001711 SmpB-tmRNA interface; other site 290339001712 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 290339001713 putative coenzyme Q binding site [chemical binding]; other site 290339001714 hypothetical protein; Validated; Region: PRK01777 290339001715 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 290339001716 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 290339001717 recombination and repair protein; Provisional; Region: PRK10869 290339001718 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 290339001719 Q-loop/lid; other site 290339001720 ABC transporter signature motif; other site 290339001721 Walker B; other site 290339001722 D-loop; other site 290339001723 H-loop/switch region; other site 290339001724 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 290339001725 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 290339001726 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 290339001727 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 290339001728 dimer interface [polypeptide binding]; other site 290339001729 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 290339001730 hypothetical protein; Provisional; Region: PRK11573 290339001731 Domain of unknown function DUF21; Region: DUF21; pfam01595 290339001732 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 290339001733 Transporter associated domain; Region: CorC_HlyC; smart01091 290339001734 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 290339001735 signal recognition particle protein; Provisional; Region: PRK10867 290339001736 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 290339001737 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 290339001738 P loop; other site 290339001739 GTP binding site [chemical binding]; other site 290339001740 Signal peptide binding domain; Region: SRP_SPB; pfam02978 290339001741 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 290339001742 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 290339001743 RimM N-terminal domain; Region: RimM; pfam01782 290339001744 PRC-barrel domain; Region: PRC; pfam05239 290339001745 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 290339001746 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 290339001747 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 290339001748 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 290339001749 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 290339001750 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 290339001751 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 290339001752 Chorismate mutase type II; Region: CM_2; cl00693 290339001753 prephenate dehydrogenase; Validated; Region: PRK08507 290339001754 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 290339001755 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 290339001756 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 290339001757 Prephenate dehydratase; Region: PDT; pfam00800 290339001758 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 290339001759 putative L-Phe binding site [chemical binding]; other site 290339001760 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 290339001761 30S subunit binding site; other site 290339001762 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 290339001763 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 290339001764 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 290339001765 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 290339001766 RNA binding surface [nucleotide binding]; other site 290339001767 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 290339001768 active site 290339001769 hypothetical protein; Provisional; Region: PRK10723 290339001770 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 290339001771 protein disaggregation chaperone; Provisional; Region: PRK10865 290339001772 Clp amino terminal domain; Region: Clp_N; pfam02861 290339001773 Clp amino terminal domain; Region: Clp_N; pfam02861 290339001774 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290339001775 Walker A motif; other site 290339001776 ATP binding site [chemical binding]; other site 290339001777 Walker B motif; other site 290339001778 arginine finger; other site 290339001779 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290339001780 Walker A motif; other site 290339001781 ATP binding site [chemical binding]; other site 290339001782 Walker B motif; other site 290339001783 arginine finger; other site 290339001784 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 290339001785 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 290339001786 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 290339001787 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290339001788 non-specific DNA binding site [nucleotide binding]; other site 290339001789 salt bridge; other site 290339001790 sequence-specific DNA binding site [nucleotide binding]; other site 290339001791 2TM domain; Region: 2TM; pfam13239 290339001792 thiamine pyrophosphate protein; Provisional; Region: PRK08273 290339001793 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 290339001794 PYR/PP interface [polypeptide binding]; other site 290339001795 dimer interface [polypeptide binding]; other site 290339001796 tetramer interface [polypeptide binding]; other site 290339001797 TPP binding site [chemical binding]; other site 290339001798 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 290339001799 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 290339001800 TPP-binding site [chemical binding]; other site 290339001801 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 290339001802 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 290339001803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339001804 putative substrate translocation pore; other site 290339001805 lipoprotein; Provisional; Region: PRK10759 290339001806 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 290339001807 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 290339001808 domain interface [polypeptide binding]; other site 290339001809 putative active site [active] 290339001810 catalytic site [active] 290339001811 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 290339001812 domain interface [polypeptide binding]; other site 290339001813 putative active site [active] 290339001814 catalytic site [active] 290339001815 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 290339001816 CoA binding domain; Region: CoA_binding_2; pfam13380 290339001817 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 290339001818 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 290339001819 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 290339001820 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 290339001821 Uncharacterized conserved protein [Function unknown]; Region: COG3148 290339001822 thioredoxin 2; Provisional; Region: PRK10996 290339001823 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 290339001824 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 290339001825 catalytic residues [active] 290339001826 putative methyltransferase; Provisional; Region: PRK10864 290339001827 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 290339001828 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 290339001829 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 290339001830 ligand binding site [chemical binding]; other site 290339001831 active site 290339001832 UGI interface [polypeptide binding]; other site 290339001833 catalytic site [active] 290339001834 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 290339001835 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 290339001836 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 290339001837 ATP binding site [chemical binding]; other site 290339001838 Mg++ binding site [ion binding]; other site 290339001839 motif III; other site 290339001840 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290339001841 nucleotide binding region [chemical binding]; other site 290339001842 ATP-binding site [chemical binding]; other site 290339001843 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 290339001844 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290339001845 S-adenosylmethionine binding site [chemical binding]; other site 290339001846 L-aspartate oxidase; Provisional; Region: PRK09077 290339001847 L-aspartate oxidase; Provisional; Region: PRK06175 290339001848 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 290339001849 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 290339001850 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290339001851 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290339001852 DNA binding residues [nucleotide binding] 290339001853 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 290339001854 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 290339001855 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 290339001856 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 290339001857 anti-sigma E factor; Provisional; Region: rseB; PRK09455 290339001858 SoxR reducing system protein RseC; Provisional; Region: PRK10862 290339001859 GTP-binding protein LepA; Provisional; Region: PRK05433 290339001860 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 290339001861 G1 box; other site 290339001862 putative GEF interaction site [polypeptide binding]; other site 290339001863 GTP/Mg2+ binding site [chemical binding]; other site 290339001864 Switch I region; other site 290339001865 G2 box; other site 290339001866 G3 box; other site 290339001867 Switch II region; other site 290339001868 G4 box; other site 290339001869 G5 box; other site 290339001870 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 290339001871 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 290339001872 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 290339001873 signal peptidase I; Provisional; Region: PRK10861 290339001874 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 290339001875 Catalytic site [active] 290339001876 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 290339001877 GTPase Era; Reviewed; Region: era; PRK00089 290339001878 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 290339001879 G1 box; other site 290339001880 GTP/Mg2+ binding site [chemical binding]; other site 290339001881 Switch I region; other site 290339001882 G2 box; other site 290339001883 Switch II region; other site 290339001884 G3 box; other site 290339001885 G4 box; other site 290339001886 G5 box; other site 290339001887 KH domain; Region: KH_2; pfam07650 290339001888 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 290339001889 Recombination protein O N terminal; Region: RecO_N; pfam11967 290339001890 Recombination protein O C terminal; Region: RecO_C; pfam02565 290339001891 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 290339001892 active site 290339001893 hydrophilic channel; other site 290339001894 dimerization interface [polypeptide binding]; other site 290339001895 catalytic residues [active] 290339001896 active site lid [active] 290339001897 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 290339001898 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 290339001899 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 290339001900 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 290339001901 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 290339001902 putative active site [active] 290339001903 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 290339001904 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 290339001905 putative active site [active] 290339001906 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 290339001907 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 290339001908 active site turn [active] 290339001909 phosphorylation site [posttranslational modification] 290339001910 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 290339001911 hypothetical protein; Provisional; Region: PRK11590 290339001912 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 290339001913 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 290339001914 nucleoside/Zn binding site; other site 290339001915 dimer interface [polypeptide binding]; other site 290339001916 catalytic motif [active] 290339001917 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 290339001918 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290339001919 substrate binding pocket [chemical binding]; other site 290339001920 membrane-bound complex binding site; other site 290339001921 hinge residues; other site 290339001922 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 290339001923 N-acetyl-D-glucosamine binding site [chemical binding]; other site 290339001924 catalytic residue [active] 290339001925 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 290339001926 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 290339001927 dimerization interface [polypeptide binding]; other site 290339001928 ATP binding site [chemical binding]; other site 290339001929 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 290339001930 dimerization interface [polypeptide binding]; other site 290339001931 ATP binding site [chemical binding]; other site 290339001932 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 290339001933 putative active site [active] 290339001934 catalytic triad [active] 290339001935 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 290339001936 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290339001937 dimer interface [polypeptide binding]; other site 290339001938 phosphorylation site [posttranslational modification] 290339001939 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290339001940 ATP binding site [chemical binding]; other site 290339001941 Mg2+ binding site [ion binding]; other site 290339001942 G-X-G motif; other site 290339001943 hypothetical protein; Provisional; Region: PRK10722 290339001944 response regulator GlrR; Provisional; Region: PRK15115 290339001945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290339001946 active site 290339001947 phosphorylation site [posttranslational modification] 290339001948 intermolecular recognition site; other site 290339001949 dimerization interface [polypeptide binding]; other site 290339001950 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290339001951 Walker A motif; other site 290339001952 ATP binding site [chemical binding]; other site 290339001953 Walker B motif; other site 290339001954 arginine finger; other site 290339001955 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 290339001956 Nitrogen regulatory protein P-II; Region: P-II; smart00938 290339001957 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 290339001958 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 290339001959 heme-binding site [chemical binding]; other site 290339001960 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 290339001961 FAD binding pocket [chemical binding]; other site 290339001962 FAD binding motif [chemical binding]; other site 290339001963 phosphate binding motif [ion binding]; other site 290339001964 beta-alpha-beta structure motif; other site 290339001965 NAD binding pocket [chemical binding]; other site 290339001966 Heme binding pocket [chemical binding]; other site 290339001967 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 290339001968 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 290339001969 dimer interface [polypeptide binding]; other site 290339001970 active site 290339001971 glycine-pyridoxal phosphate binding site [chemical binding]; other site 290339001972 folate binding site [chemical binding]; other site 290339001973 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 290339001974 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 290339001975 DNA binding residues [nucleotide binding] 290339001976 putative dimer interface [polypeptide binding]; other site 290339001977 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 290339001978 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 290339001979 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339001980 putative substrate translocation pore; other site 290339001981 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 290339001982 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 290339001983 PRD domain; Region: PRD; pfam00874 290339001984 PRD domain; Region: PRD; pfam00874 290339001985 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 290339001986 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 290339001987 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 290339001988 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 290339001989 active site 290339001990 dimerization interface [polypeptide binding]; other site 290339001991 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 290339001992 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 290339001993 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 290339001994 Rrf2 family protein; Region: rrf2_super; TIGR00738 290339001995 cysteine desulfurase; Provisional; Region: PRK14012 290339001996 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 290339001997 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290339001998 catalytic residue [active] 290339001999 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 290339002000 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 290339002001 trimerization site [polypeptide binding]; other site 290339002002 active site 290339002003 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 290339002004 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 290339002005 chaperone protein HscA; Provisional; Region: hscA; PRK05183 290339002006 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 290339002007 nucleotide binding site [chemical binding]; other site 290339002008 putative NEF/HSP70 interaction site [polypeptide binding]; other site 290339002009 SBD interface [polypeptide binding]; other site 290339002010 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 290339002011 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 290339002012 catalytic loop [active] 290339002013 iron binding site [ion binding]; other site 290339002014 hypothetical protein; Provisional; Region: PRK10721 290339002015 aminopeptidase B; Provisional; Region: PRK05015 290339002016 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 290339002017 interface (dimer of trimers) [polypeptide binding]; other site 290339002018 Substrate-binding/catalytic site; other site 290339002019 Zn-binding sites [ion binding]; other site 290339002020 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 290339002021 Peptidase family M48; Region: Peptidase_M48; cl12018 290339002022 Peptidase family M48; Region: Peptidase_M48; cl12018 290339002023 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 290339002024 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 290339002025 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 290339002026 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 290339002027 putative active site [active] 290339002028 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 290339002029 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 290339002030 active site residue [active] 290339002031 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 290339002032 active site residue [active] 290339002033 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 290339002034 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 290339002035 NAD binding site [chemical binding]; other site 290339002036 sugar binding site [chemical binding]; other site 290339002037 divalent metal binding site [ion binding]; other site 290339002038 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 290339002039 dimer interface [polypeptide binding]; other site 290339002040 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 290339002041 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 290339002042 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 290339002043 active site turn [active] 290339002044 phosphorylation site [posttranslational modification] 290339002045 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 290339002046 MG2 domain; Region: A2M_N; pfam01835 290339002047 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 290339002048 surface patch; other site 290339002049 thioester region; other site 290339002050 penicillin-binding protein 1C; Provisional; Region: PRK11240 290339002051 Transglycosylase; Region: Transgly; pfam00912 290339002052 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 290339002053 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 290339002054 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 290339002055 active site 290339002056 multimer interface [polypeptide binding]; other site 290339002057 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 290339002058 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290339002059 FeS/SAM binding site; other site 290339002060 cytoskeletal protein RodZ; Provisional; Region: PRK10856 290339002061 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290339002062 non-specific DNA binding site [nucleotide binding]; other site 290339002063 salt bridge; other site 290339002064 sequence-specific DNA binding site [nucleotide binding]; other site 290339002065 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 290339002066 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 290339002067 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 290339002068 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 290339002069 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 290339002070 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 290339002071 dimer interface [polypeptide binding]; other site 290339002072 motif 1; other site 290339002073 active site 290339002074 motif 2; other site 290339002075 motif 3; other site 290339002076 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 290339002077 anticodon binding site; other site 290339002078 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 290339002079 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 290339002080 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 290339002081 Trp docking motif [polypeptide binding]; other site 290339002082 GTP-binding protein Der; Reviewed; Region: PRK00093 290339002083 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 290339002084 G1 box; other site 290339002085 GTP/Mg2+ binding site [chemical binding]; other site 290339002086 Switch I region; other site 290339002087 G2 box; other site 290339002088 Switch II region; other site 290339002089 G3 box; other site 290339002090 G4 box; other site 290339002091 G5 box; other site 290339002092 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 290339002093 G1 box; other site 290339002094 GTP/Mg2+ binding site [chemical binding]; other site 290339002095 Switch I region; other site 290339002096 G2 box; other site 290339002097 G3 box; other site 290339002098 Switch II region; other site 290339002099 G4 box; other site 290339002100 G5 box; other site 290339002101 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 290339002102 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 290339002103 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 290339002104 active site 290339002105 Zn binding site [ion binding]; other site 290339002106 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 290339002107 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 290339002108 generic binding surface II; other site 290339002109 generic binding surface I; other site 290339002110 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 290339002111 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 290339002112 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 290339002113 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 290339002114 active site 290339002115 GMP synthase; Reviewed; Region: guaA; PRK00074 290339002116 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 290339002117 AMP/PPi binding site [chemical binding]; other site 290339002118 candidate oxyanion hole; other site 290339002119 catalytic triad [active] 290339002120 potential glutamine specificity residues [chemical binding]; other site 290339002121 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 290339002122 ATP Binding subdomain [chemical binding]; other site 290339002123 Ligand Binding sites [chemical binding]; other site 290339002124 Dimerization subdomain; other site 290339002125 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 290339002126 MASE1; Region: MASE1; pfam05231 290339002127 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 290339002128 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 290339002129 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290339002130 exopolyphosphatase; Provisional; Region: PRK10854 290339002131 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 290339002132 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 290339002133 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 290339002134 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 290339002135 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 290339002136 putative active site [active] 290339002137 catalytic site [active] 290339002138 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 290339002139 domain interface [polypeptide binding]; other site 290339002140 active site 290339002141 catalytic site [active] 290339002142 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 290339002143 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 290339002144 active site 290339002145 substrate binding site [chemical binding]; other site 290339002146 cosubstrate binding site; other site 290339002147 catalytic site [active] 290339002148 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 290339002149 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 290339002150 dimerization interface [polypeptide binding]; other site 290339002151 putative ATP binding site [chemical binding]; other site 290339002152 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290339002153 active site 290339002154 uracil transporter; Provisional; Region: PRK10720 290339002155 DNA replication initiation factor; Provisional; Region: PRK08084 290339002156 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 290339002157 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 290339002158 ArsC family; Region: ArsC; pfam03960 290339002159 catalytic residues [active] 290339002160 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 290339002161 Peptidase family M48; Region: Peptidase_M48; cl12018 290339002162 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 290339002163 Domain of unknown function DUF20; Region: UPF0118; pfam01594 290339002164 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 290339002165 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 290339002166 catalytic triad [active] 290339002167 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 290339002168 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 290339002169 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 290339002170 dihydrodipicolinate synthase; Region: dapA; TIGR00674 290339002171 dimer interface [polypeptide binding]; other site 290339002172 active site 290339002173 catalytic residue [active] 290339002174 lipoprotein; Provisional; Region: PRK11679 290339002175 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 290339002176 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 290339002177 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 290339002178 ATP binding site [chemical binding]; other site 290339002179 active site 290339002180 substrate binding site [chemical binding]; other site 290339002181 Predicted metalloprotease [General function prediction only]; Region: COG2321 290339002182 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 290339002183 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 290339002184 Helicase; Region: Helicase_RecD; pfam05127 290339002185 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290339002186 Coenzyme A binding pocket [chemical binding]; other site 290339002187 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 290339002188 putative hydrolase; Provisional; Region: PRK11460 290339002189 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 290339002190 hypothetical protein; Provisional; Region: PRK13664 290339002191 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 290339002192 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 290339002193 metal binding site [ion binding]; metal-binding site 290339002194 dimer interface [polypeptide binding]; other site 290339002195 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 290339002196 ArsC family; Region: ArsC; pfam03960 290339002197 putative catalytic residues [active] 290339002198 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290339002199 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 290339002200 Coenzyme A binding pocket [chemical binding]; other site 290339002201 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 290339002202 Protein export membrane protein; Region: SecD_SecF; cl14618 290339002203 transcriptional regulator NarP; Provisional; Region: PRK10403 290339002204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290339002205 active site 290339002206 phosphorylation site [posttranslational modification] 290339002207 intermolecular recognition site; other site 290339002208 dimerization interface [polypeptide binding]; other site 290339002209 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290339002210 DNA binding residues [nucleotide binding] 290339002211 dimerization interface [polypeptide binding]; other site 290339002212 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 290339002213 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 290339002214 dimer interface [polypeptide binding]; other site 290339002215 ADP-ribose binding site [chemical binding]; other site 290339002216 active site 290339002217 nudix motif; other site 290339002218 metal binding site [ion binding]; metal-binding site 290339002219 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 290339002220 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 290339002221 transketolase; Reviewed; Region: PRK12753 290339002222 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 290339002223 TPP-binding site [chemical binding]; other site 290339002224 dimer interface [polypeptide binding]; other site 290339002225 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 290339002226 PYR/PP interface [polypeptide binding]; other site 290339002227 dimer interface [polypeptide binding]; other site 290339002228 TPP binding site [chemical binding]; other site 290339002229 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290339002230 transaldolase-like protein; Provisional; Region: PTZ00411 290339002231 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 290339002232 active site 290339002233 dimer interface [polypeptide binding]; other site 290339002234 catalytic residue [active] 290339002235 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 290339002236 Malic enzyme, N-terminal domain; Region: malic; pfam00390 290339002237 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 290339002238 putative NAD(P) binding site [chemical binding]; other site 290339002239 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 290339002240 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 290339002241 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 290339002242 Walker A/P-loop; other site 290339002243 ATP binding site [chemical binding]; other site 290339002244 Q-loop/lid; other site 290339002245 ABC transporter signature motif; other site 290339002246 Walker B; other site 290339002247 D-loop; other site 290339002248 H-loop/switch region; other site 290339002249 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 290339002250 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290339002251 ABC-ATPase subunit interface; other site 290339002252 dimer interface [polypeptide binding]; other site 290339002253 putative PBP binding regions; other site 290339002254 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 290339002255 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 290339002256 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290339002257 ABC-ATPase subunit interface; other site 290339002258 dimer interface [polypeptide binding]; other site 290339002259 putative PBP binding regions; other site 290339002260 enterobactin exporter EntS; Provisional; Region: PRK10489 290339002261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339002262 putative substrate translocation pore; other site 290339002263 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 290339002264 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 290339002265 siderophore binding site; other site 290339002266 isochorismate synthase EntC; Provisional; Region: PRK15016 290339002267 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 290339002268 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 290339002269 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 290339002270 acyl-activating enzyme (AAE) consensus motif; other site 290339002271 active site 290339002272 AMP binding site [chemical binding]; other site 290339002273 substrate binding site [chemical binding]; other site 290339002274 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 290339002275 hydrophobic substrate binding pocket; other site 290339002276 Isochorismatase family; Region: Isochorismatase; pfam00857 290339002277 active site 290339002278 conserved cis-peptide bond; other site 290339002279 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 290339002280 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 290339002281 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290339002282 NAD(P) binding site [chemical binding]; other site 290339002283 active site 290339002284 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 290339002285 CoenzymeA binding site [chemical binding]; other site 290339002286 subunit interaction site [polypeptide binding]; other site 290339002287 PHB binding site; other site 290339002288 carbon starvation protein A; Provisional; Region: PRK15015 290339002289 Carbon starvation protein CstA; Region: CstA; pfam02554 290339002290 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 290339002291 Uncharacterized small protein [Function unknown]; Region: COG2879 290339002292 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290339002293 salt bridge; other site 290339002294 non-specific DNA binding site [nucleotide binding]; other site 290339002295 sequence-specific DNA binding site [nucleotide binding]; other site 290339002296 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 290339002297 enterobactin exporter EntS; Provisional; Region: PRK10489 290339002298 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339002299 putative substrate translocation pore; other site 290339002300 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 290339002301 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 290339002302 putative active site [active] 290339002303 metal binding site [ion binding]; metal-binding site 290339002304 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 290339002305 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 290339002306 Walker A/P-loop; other site 290339002307 ATP binding site [chemical binding]; other site 290339002308 Q-loop/lid; other site 290339002309 ABC transporter signature motif; other site 290339002310 Walker B; other site 290339002311 D-loop; other site 290339002312 H-loop/switch region; other site 290339002313 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 290339002314 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290339002315 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290339002316 TM-ABC transporter signature motif; other site 290339002317 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 290339002318 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 290339002319 putative ligand binding site [chemical binding]; other site 290339002320 Uncharacterized conserved protein [Function unknown]; Region: COG5276 290339002321 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 290339002322 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 290339002323 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 290339002324 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 290339002325 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 290339002326 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 290339002327 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 290339002328 active site 290339002329 metal binding site [ion binding]; metal-binding site 290339002330 putative acetyltransferase; Provisional; Region: PRK03624 290339002331 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290339002332 Coenzyme A binding pocket [chemical binding]; other site 290339002333 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 290339002334 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 290339002335 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 290339002336 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 290339002337 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 290339002338 thiosulfate transporter subunit; Provisional; Region: PRK10852 290339002339 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 290339002340 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 290339002341 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339002342 dimer interface [polypeptide binding]; other site 290339002343 conserved gate region; other site 290339002344 putative PBP binding loops; other site 290339002345 ABC-ATPase subunit interface; other site 290339002346 sulfate transport protein; Provisional; Region: cysT; CHL00187 290339002347 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339002348 dimer interface [polypeptide binding]; other site 290339002349 conserved gate region; other site 290339002350 putative PBP binding loops; other site 290339002351 ABC-ATPase subunit interface; other site 290339002352 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 290339002353 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 290339002354 Walker A/P-loop; other site 290339002355 ATP binding site [chemical binding]; other site 290339002356 Q-loop/lid; other site 290339002357 ABC transporter signature motif; other site 290339002358 Walker B; other site 290339002359 D-loop; other site 290339002360 H-loop/switch region; other site 290339002361 TOBE-like domain; Region: TOBE_3; pfam12857 290339002362 cysteine synthase B; Region: cysM; TIGR01138 290339002363 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 290339002364 dimer interface [polypeptide binding]; other site 290339002365 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339002366 catalytic residue [active] 290339002367 hypothetical protein; Provisional; Region: PRK10318 290339002368 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 290339002369 HPr interaction site; other site 290339002370 glycerol kinase (GK) interaction site [polypeptide binding]; other site 290339002371 active site 290339002372 phosphorylation site [posttranslational modification] 290339002373 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 290339002374 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 290339002375 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 290339002376 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 290339002377 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 290339002378 dimerization domain swap beta strand [polypeptide binding]; other site 290339002379 regulatory protein interface [polypeptide binding]; other site 290339002380 active site 290339002381 regulatory phosphorylation site [posttranslational modification]; other site 290339002382 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 290339002383 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 290339002384 dimer interface [polypeptide binding]; other site 290339002385 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339002386 catalytic residue [active] 290339002387 putative sulfate transport protein CysZ; Validated; Region: PRK04949 290339002388 cell division protein ZipA; Provisional; Region: PRK03427 290339002389 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 290339002390 FtsZ protein binding site [polypeptide binding]; other site 290339002391 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 290339002392 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 290339002393 nucleotide binding pocket [chemical binding]; other site 290339002394 K-X-D-G motif; other site 290339002395 catalytic site [active] 290339002396 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 290339002397 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 290339002398 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 290339002399 Dimer interface [polypeptide binding]; other site 290339002400 BRCT sequence motif; other site 290339002401 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 290339002402 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 290339002403 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 290339002404 active site 290339002405 HIGH motif; other site 290339002406 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 290339002407 active site 290339002408 KMSKS motif; other site 290339002409 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 290339002410 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 290339002411 MASE1; Region: MASE1; cl17823 290339002412 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 290339002413 diguanylate cyclase; Region: GGDEF; smart00267 290339002414 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290339002415 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 290339002416 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 290339002417 Nucleoside recognition; Region: Gate; pfam07670 290339002418 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 290339002419 manganese transport protein MntH; Reviewed; Region: PRK00701 290339002420 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 290339002421 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 290339002422 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290339002423 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290339002424 active site 290339002425 catalytic tetrad [active] 290339002426 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 290339002427 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 290339002428 dimer interface [polypeptide binding]; other site 290339002429 PYR/PP interface [polypeptide binding]; other site 290339002430 TPP binding site [chemical binding]; other site 290339002431 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 290339002432 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 290339002433 TPP-binding site [chemical binding]; other site 290339002434 dimer interface [polypeptide binding]; other site 290339002435 glucokinase, proteobacterial type; Region: glk; TIGR00749 290339002436 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 290339002437 nucleotide binding site [chemical binding]; other site 290339002438 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 290339002439 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290339002440 active site 290339002441 phosphorylation site [posttranslational modification] 290339002442 intermolecular recognition site; other site 290339002443 dimerization interface [polypeptide binding]; other site 290339002444 LytTr DNA-binding domain; Region: LytTR; pfam04397 290339002445 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 290339002446 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 290339002447 GAF domain; Region: GAF_3; pfam13492 290339002448 Histidine kinase; Region: His_kinase; pfam06580 290339002449 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290339002450 ATP binding site [chemical binding]; other site 290339002451 Mg2+ binding site [ion binding]; other site 290339002452 G-X-G motif; other site 290339002453 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 290339002454 aminotransferase; Validated; Region: PRK08175 290339002455 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290339002456 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339002457 homodimer interface [polypeptide binding]; other site 290339002458 catalytic residue [active] 290339002459 Cupin domain; Region: Cupin_2; pfam07883 290339002460 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 290339002461 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 290339002462 oligomer interface [polypeptide binding]; other site 290339002463 metal binding site [ion binding]; metal-binding site 290339002464 metal binding site [ion binding]; metal-binding site 290339002465 putative Cl binding site [ion binding]; other site 290339002466 basic sphincter; other site 290339002467 hydrophobic gate; other site 290339002468 periplasmic entrance; other site 290339002469 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290339002470 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339002471 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 290339002472 putative dimerization interface [polypeptide binding]; other site 290339002473 putative substrate binding pocket [chemical binding]; other site 290339002474 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 290339002475 acetolactate synthase; Reviewed; Region: PRK08617 290339002476 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 290339002477 PYR/PP interface [polypeptide binding]; other site 290339002478 dimer interface [polypeptide binding]; other site 290339002479 TPP binding site [chemical binding]; other site 290339002480 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 290339002481 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 290339002482 TPP-binding site [chemical binding]; other site 290339002483 acetoin reductase; Validated; Region: PRK08643 290339002484 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 290339002485 NAD binding site [chemical binding]; other site 290339002486 homotetramer interface [polypeptide binding]; other site 290339002487 homodimer interface [polypeptide binding]; other site 290339002488 active site 290339002489 substrate binding site [chemical binding]; other site 290339002490 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 290339002491 amphipathic channel; other site 290339002492 Asn-Pro-Ala signature motifs; other site 290339002493 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 290339002494 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 290339002495 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 290339002496 Walker A/P-loop; other site 290339002497 ATP binding site [chemical binding]; other site 290339002498 Q-loop/lid; other site 290339002499 ABC transporter signature motif; other site 290339002500 Walker B; other site 290339002501 D-loop; other site 290339002502 H-loop/switch region; other site 290339002503 heme exporter protein CcmB; Region: ccmB; TIGR01190 290339002504 heme exporter protein CcmC; Region: ccmC; TIGR01191 290339002505 Heme exporter protein D (CcmD); Region: CcmD; cl11475 290339002506 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150 290339002507 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 290339002508 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 290339002509 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 290339002510 catalytic residues [active] 290339002511 central insert; other site 290339002512 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 290339002513 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 290339002514 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290339002515 binding surface 290339002516 TPR motif; other site 290339002517 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 290339002518 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 290339002519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 290339002520 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 290339002521 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 290339002522 dimer interface [polypeptide binding]; other site 290339002523 active site 290339002524 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 290339002525 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 290339002526 substrate binding site [chemical binding]; other site 290339002527 oxyanion hole (OAH) forming residues; other site 290339002528 trimer interface [polypeptide binding]; other site 290339002529 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 290339002530 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 290339002531 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290339002532 catalytic core [active] 290339002533 hypothetical protein; Provisional; Region: PRK04946 290339002534 Smr domain; Region: Smr; pfam01713 290339002535 HemK family putative methylases; Region: hemK_fam; TIGR00536 290339002536 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290339002537 S-adenosylmethionine binding site [chemical binding]; other site 290339002538 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 290339002539 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 290339002540 Tetramer interface [polypeptide binding]; other site 290339002541 active site 290339002542 FMN-binding site [chemical binding]; other site 290339002543 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 290339002544 hypothetical protein; Provisional; Region: PRK10621 290339002545 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 290339002546 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 290339002547 YfcL protein; Region: YfcL; pfam08891 290339002548 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 290339002549 Uncharacterized conserved protein [Function unknown]; Region: COG4121 290339002550 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 290339002551 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 290339002552 dimer interface [polypeptide binding]; other site 290339002553 active site 290339002554 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 290339002555 catalytic triad [active] 290339002556 putative active site [active] 290339002557 Autotransporter beta-domain; Region: Autotransporter; smart00869 290339002558 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 290339002559 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 290339002560 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 290339002561 ligand binding site [chemical binding]; other site 290339002562 NAD binding site [chemical binding]; other site 290339002563 catalytic site [active] 290339002564 homodimer interface [polypeptide binding]; other site 290339002565 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 290339002566 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 290339002567 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 290339002568 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 290339002569 dimerization interface 3.5A [polypeptide binding]; other site 290339002570 active site 290339002571 hypothetical protein; Provisional; Region: PRK10847 290339002572 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 290339002573 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 290339002574 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 290339002575 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 290339002576 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 290339002577 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 290339002578 cell division protein DedD; Provisional; Region: PRK11633 290339002579 Sporulation related domain; Region: SPOR; pfam05036 290339002580 colicin V production protein; Provisional; Region: PRK10845 290339002581 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 290339002582 amidophosphoribosyltransferase; Provisional; Region: PRK09246 290339002583 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 290339002584 active site 290339002585 tetramer interface [polypeptide binding]; other site 290339002586 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290339002587 active site 290339002588 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 290339002589 Flavoprotein; Region: Flavoprotein; pfam02441 290339002590 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 290339002591 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290339002592 substrate binding pocket [chemical binding]; other site 290339002593 membrane-bound complex binding site; other site 290339002594 hinge residues; other site 290339002595 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 290339002596 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290339002597 substrate binding pocket [chemical binding]; other site 290339002598 membrane-bound complex binding site; other site 290339002599 hinge residues; other site 290339002600 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 290339002601 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339002602 dimer interface [polypeptide binding]; other site 290339002603 conserved gate region; other site 290339002604 putative PBP binding loops; other site 290339002605 ABC-ATPase subunit interface; other site 290339002606 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 290339002607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339002608 dimer interface [polypeptide binding]; other site 290339002609 conserved gate region; other site 290339002610 putative PBP binding loops; other site 290339002611 ABC-ATPase subunit interface; other site 290339002612 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 290339002613 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 290339002614 Walker A/P-loop; other site 290339002615 ATP binding site [chemical binding]; other site 290339002616 Q-loop/lid; other site 290339002617 ABC transporter signature motif; other site 290339002618 Walker B; other site 290339002619 D-loop; other site 290339002620 H-loop/switch region; other site 290339002621 RES domain; Region: RES; smart00953 290339002622 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290339002623 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 290339002624 NAD(P) binding site [chemical binding]; other site 290339002625 active site 290339002626 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 290339002627 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 290339002628 C-terminal domain interface [polypeptide binding]; other site 290339002629 GSH binding site (G-site) [chemical binding]; other site 290339002630 dimer interface [polypeptide binding]; other site 290339002631 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 290339002632 N-terminal domain interface [polypeptide binding]; other site 290339002633 putative dimer interface [polypeptide binding]; other site 290339002634 active site 290339002635 glutathione S-transferase; Provisional; Region: PRK15113 290339002636 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 290339002637 C-terminal domain interface [polypeptide binding]; other site 290339002638 GSH binding site (G-site) [chemical binding]; other site 290339002639 dimer interface [polypeptide binding]; other site 290339002640 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 290339002641 N-terminal domain interface [polypeptide binding]; other site 290339002642 putative dimer interface [polypeptide binding]; other site 290339002643 putative substrate binding pocket (H-site) [chemical binding]; other site 290339002644 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 290339002645 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 290339002646 active site 290339002647 metal binding site [ion binding]; metal-binding site 290339002648 homotetramer interface [polypeptide binding]; other site 290339002649 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 290339002650 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 290339002651 nudix motif; other site 290339002652 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290339002653 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290339002654 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 290339002655 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290339002656 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290339002657 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 290339002658 phosphate acetyltransferase; Reviewed; Region: PRK05632 290339002659 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 290339002660 DRTGG domain; Region: DRTGG; pfam07085 290339002661 phosphate acetyltransferase; Region: pta; TIGR00651 290339002662 propionate/acetate kinase; Provisional; Region: PRK12379 290339002663 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 290339002664 hypothetical protein; Provisional; Region: PRK01816 290339002665 hypothetical protein; Validated; Region: PRK05445 290339002666 putative phosphatase; Provisional; Region: PRK11587 290339002667 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290339002668 motif II; other site 290339002669 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 290339002670 transmembrane helices; other site 290339002671 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 290339002672 TrkA-C domain; Region: TrkA_C; pfam02080 290339002673 TrkA-C domain; Region: TrkA_C; pfam02080 290339002674 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 290339002675 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 290339002676 Zn2+ binding site [ion binding]; other site 290339002677 Mg2+ binding site [ion binding]; other site 290339002678 aminotransferase AlaT; Validated; Region: PRK09265 290339002679 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290339002680 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339002681 homodimer interface [polypeptide binding]; other site 290339002682 catalytic residue [active] 290339002683 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 290339002684 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339002685 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 290339002686 putative dimerization interface [polypeptide binding]; other site 290339002687 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 290339002688 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 290339002689 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 290339002690 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 290339002691 NADH dehydrogenase subunit D; Validated; Region: PRK06075 290339002692 NADH dehydrogenase subunit E; Validated; Region: PRK07539 290339002693 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 290339002694 putative dimer interface [polypeptide binding]; other site 290339002695 [2Fe-2S] cluster binding site [ion binding]; other site 290339002696 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 290339002697 SLBB domain; Region: SLBB; pfam10531 290339002698 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 290339002699 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 290339002700 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 290339002701 catalytic loop [active] 290339002702 iron binding site [ion binding]; other site 290339002703 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 290339002704 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 290339002705 [4Fe-4S] binding site [ion binding]; other site 290339002706 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 290339002707 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 290339002708 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 290339002709 4Fe-4S binding domain; Region: Fer4; pfam00037 290339002710 4Fe-4S binding domain; Region: Fer4; pfam00037 290339002711 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 290339002712 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 290339002713 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 290339002714 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 290339002715 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 290339002716 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 290339002717 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 290339002718 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 290339002719 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 290339002720 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 290339002721 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 290339002722 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290339002723 Coenzyme A binding pocket [chemical binding]; other site 290339002724 hypothetical protein; Provisional; Region: PRK10404 290339002725 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 290339002726 chorismate binding enzyme; Region: Chorismate_bind; cl10555 290339002727 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 290339002728 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 290339002729 dimer interface [polypeptide binding]; other site 290339002730 tetramer interface [polypeptide binding]; other site 290339002731 PYR/PP interface [polypeptide binding]; other site 290339002732 TPP binding site [chemical binding]; other site 290339002733 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 290339002734 TPP-binding site; other site 290339002735 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 290339002736 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 290339002737 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 290339002738 substrate binding site [chemical binding]; other site 290339002739 oxyanion hole (OAH) forming residues; other site 290339002740 trimer interface [polypeptide binding]; other site 290339002741 O-succinylbenzoate synthase; Provisional; Region: PRK05105 290339002742 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 290339002743 active site 290339002744 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 290339002745 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 290339002746 acyl-activating enzyme (AAE) consensus motif; other site 290339002747 putative AMP binding site [chemical binding]; other site 290339002748 putative active site [active] 290339002749 putative CoA binding site [chemical binding]; other site 290339002750 hypothetical protein; Provisional; Region: PRK09867 290339002751 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 290339002752 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 290339002753 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 290339002754 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 290339002755 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290339002756 active site 290339002757 phosphorylation site [posttranslational modification] 290339002758 intermolecular recognition site; other site 290339002759 dimerization interface [polypeptide binding]; other site 290339002760 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290339002761 DNA binding site [nucleotide binding] 290339002762 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 290339002763 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 290339002764 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 290339002765 dimerization interface [polypeptide binding]; other site 290339002766 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290339002767 dimer interface [polypeptide binding]; other site 290339002768 phosphorylation site [posttranslational modification] 290339002769 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290339002770 ATP binding site [chemical binding]; other site 290339002771 G-X-G motif; other site 290339002772 YfaZ precursor; Region: YfaZ; pfam07437 290339002773 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 290339002774 hypothetical protein; Provisional; Region: PRK03673 290339002775 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 290339002776 putative MPT binding site; other site 290339002777 Competence-damaged protein; Region: CinA; cl00666 290339002778 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 290339002779 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339002780 putative substrate translocation pore; other site 290339002781 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 290339002782 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 290339002783 active site 290339002784 catalytic site [active] 290339002785 metal binding site [ion binding]; metal-binding site 290339002786 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 290339002787 catalytic loop [active] 290339002788 iron binding site [ion binding]; other site 290339002789 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 290339002790 dimer interface [polypeptide binding]; other site 290339002791 putative radical transfer pathway; other site 290339002792 diiron center [ion binding]; other site 290339002793 tyrosyl radical; other site 290339002794 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 290339002795 ATP cone domain; Region: ATP-cone; pfam03477 290339002796 Class I ribonucleotide reductase; Region: RNR_I; cd01679 290339002797 active site 290339002798 dimer interface [polypeptide binding]; other site 290339002799 catalytic residues [active] 290339002800 effector binding site; other site 290339002801 R2 peptide binding site; other site 290339002802 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 290339002803 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290339002804 S-adenosylmethionine binding site [chemical binding]; other site 290339002805 DNA gyrase subunit A; Validated; Region: PRK05560 290339002806 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 290339002807 CAP-like domain; other site 290339002808 active site 290339002809 primary dimer interface [polypeptide binding]; other site 290339002810 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290339002811 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290339002812 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290339002813 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290339002814 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290339002815 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290339002816 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 290339002817 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290339002818 dimer interface [polypeptide binding]; other site 290339002819 phosphorylation site [posttranslational modification] 290339002820 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290339002821 ATP binding site [chemical binding]; other site 290339002822 Mg2+ binding site [ion binding]; other site 290339002823 G-X-G motif; other site 290339002824 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 290339002825 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290339002826 active site 290339002827 phosphorylation site [posttranslational modification] 290339002828 intermolecular recognition site; other site 290339002829 dimerization interface [polypeptide binding]; other site 290339002830 transcriptional regulator RcsB; Provisional; Region: PRK10840 290339002831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290339002832 active site 290339002833 phosphorylation site [posttranslational modification] 290339002834 intermolecular recognition site; other site 290339002835 dimerization interface [polypeptide binding]; other site 290339002836 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290339002837 DNA binding residues [nucleotide binding] 290339002838 dimerization interface [polypeptide binding]; other site 290339002839 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 290339002840 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290339002841 ATP binding site [chemical binding]; other site 290339002842 Mg2+ binding site [ion binding]; other site 290339002843 G-X-G motif; other site 290339002844 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 290339002845 putative binding surface; other site 290339002846 active site 290339002847 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 290339002848 outer membrane porin protein C; Provisional; Region: PRK10554 290339002849 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 290339002850 ApbE family; Region: ApbE; pfam02424 290339002851 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 290339002852 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 290339002853 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290339002854 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 290339002855 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 290339002856 DNA binding site [nucleotide binding] 290339002857 active site 290339002858 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 290339002859 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 290339002860 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 290339002861 Walker A/P-loop; other site 290339002862 ATP binding site [chemical binding]; other site 290339002863 Q-loop/lid; other site 290339002864 ABC transporter signature motif; other site 290339002865 Walker B; other site 290339002866 D-loop; other site 290339002867 H-loop/switch region; other site 290339002868 high affinity sulphate transporter 1; Region: sulP; TIGR00815 290339002869 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 290339002870 Sulfate transporter family; Region: Sulfate_transp; pfam00916 290339002871 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 290339002872 KTSC domain; Region: KTSC; pfam13619 290339002873 putative chaperone protein EcpD; Provisional; Region: PRK09926 290339002874 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 290339002875 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 290339002876 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 290339002877 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 290339002878 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 290339002879 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 290339002880 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 290339002881 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 290339002882 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 290339002883 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 290339002884 transcriptional regulator SpvR; Provisional; Region: PRK15243 290339002885 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339002886 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290339002887 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 290339002888 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 290339002889 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 290339002890 active site 290339002891 DNA binding site [nucleotide binding] 290339002892 Int/Topo IB signature motif; other site 290339002893 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 290339002894 active site 290339002895 catalytic site [active] 290339002896 substrate binding site [chemical binding]; other site 290339002897 Methyltransferase domain; Region: Methyltransf_25; pfam13649 290339002898 recombination associated protein; Reviewed; Region: rdgC; PRK00321 290339002899 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 290339002900 Dimer interface [polypeptide binding]; other site 290339002901 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290339002902 non-specific DNA binding site [nucleotide binding]; other site 290339002903 Predicted transcriptional regulator [Transcription]; Region: COG2932 290339002904 salt bridge; other site 290339002905 sequence-specific DNA binding site [nucleotide binding]; other site 290339002906 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 290339002907 Catalytic site [active] 290339002908 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 290339002909 Helix-turn-helix domain; Region: HTH_36; pfam13730 290339002910 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 290339002911 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 290339002912 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 290339002913 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 290339002914 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 290339002915 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 290339002916 Protein of unknown function (DUF968); Region: DUF968; pfam06147 290339002917 Antitermination protein; Region: Antiterm; pfam03589 290339002918 Antitermination protein; Region: Antiterm; pfam03589 290339002919 Protein of unknown function (DUF754); Region: DUF754; pfam05449 290339002920 Predicted chitinase [General function prediction only]; Region: COG3179 290339002921 catalytic residue [active] 290339002922 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 290339002923 Phage terminase, small subunit; Region: Terminase_4; cl01525 290339002924 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 290339002925 Phage-related protein [Function unknown]; Region: COG4695 290339002926 Phage portal protein; Region: Phage_portal; pfam04860 290339002927 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 290339002928 oligomer interface [polypeptide binding]; other site 290339002929 active site residues [active] 290339002930 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 290339002931 Phage capsid family; Region: Phage_capsid; pfam05065 290339002932 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 290339002933 oligomerization interface [polypeptide binding]; other site 290339002934 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 290339002935 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 290339002936 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 290339002937 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 290339002938 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 290339002939 50S ribosomal protein L37Ae; Reviewed; Region: rpl37ae; PRK03976 290339002940 Phage-related minor tail protein [Function unknown]; Region: COG5281 290339002941 tape measure domain; Region: tape_meas_nterm; TIGR02675 290339002942 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 290339002943 phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541 290339002944 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 290339002945 Phage minor tail protein; Region: Phage_min_tail; pfam05939 290339002946 Phage-related protein [Function unknown]; Region: gp18; COG4672 290339002947 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 290339002948 MPN+ (JAMM) motif; other site 290339002949 Zinc-binding site [ion binding]; other site 290339002950 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 290339002951 NlpC/P60 family; Region: NLPC_P60; cl17555 290339002952 Phage-related protein, tail component [Function unknown]; Region: COG4723 290339002953 Phage-related protein, tail component [Function unknown]; Region: COG4733 290339002954 Putative phage tail protein; Region: Phage-tail_3; pfam13550 290339002955 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 290339002956 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 290339002957 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 290339002958 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 290339002959 Sulfatase; Region: Sulfatase; cl17466 290339002960 hypothetical protein; Provisional; Region: PRK13689 290339002961 Nucleoid-associated protein [General function prediction only]; Region: COG3081 290339002962 nucleoid-associated protein NdpA; Validated; Region: PRK00378 290339002963 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 290339002964 5S rRNA interface [nucleotide binding]; other site 290339002965 CTC domain interface [polypeptide binding]; other site 290339002966 L16 interface [polypeptide binding]; other site 290339002967 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 290339002968 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290339002969 ATP binding site [chemical binding]; other site 290339002970 putative Mg++ binding site [ion binding]; other site 290339002971 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290339002972 nucleotide binding region [chemical binding]; other site 290339002973 ATP-binding site [chemical binding]; other site 290339002974 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 290339002975 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 290339002976 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 290339002977 RNA binding surface [nucleotide binding]; other site 290339002978 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 290339002979 active site 290339002980 uracil binding [chemical binding]; other site 290339002981 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339002982 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 290339002983 putative substrate translocation pore; other site 290339002984 hypothetical protein; Provisional; Region: PRK11835 290339002985 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 290339002986 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290339002987 Walker A/P-loop; other site 290339002988 ATP binding site [chemical binding]; other site 290339002989 Q-loop/lid; other site 290339002990 ABC transporter signature motif; other site 290339002991 Walker B; other site 290339002992 D-loop; other site 290339002993 H-loop/switch region; other site 290339002994 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290339002995 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290339002996 Walker A/P-loop; other site 290339002997 ATP binding site [chemical binding]; other site 290339002998 Q-loop/lid; other site 290339002999 ABC transporter signature motif; other site 290339003000 Walker B; other site 290339003001 D-loop; other site 290339003002 H-loop/switch region; other site 290339003003 microcin C ABC transporter permease; Provisional; Region: PRK15021 290339003004 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339003005 dimer interface [polypeptide binding]; other site 290339003006 conserved gate region; other site 290339003007 ABC-ATPase subunit interface; other site 290339003008 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 290339003009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339003010 dimer interface [polypeptide binding]; other site 290339003011 conserved gate region; other site 290339003012 putative PBP binding loops; other site 290339003013 ABC-ATPase subunit interface; other site 290339003014 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 290339003015 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 290339003016 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 290339003017 phage resistance protein; Provisional; Region: PRK10551 290339003018 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 290339003019 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290339003020 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 290339003021 NlpC/P60 family; Region: NLPC_P60; pfam00877 290339003022 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 290339003023 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 290339003024 active site 290339003025 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 290339003026 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 290339003027 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 290339003028 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 290339003029 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 290339003030 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 290339003031 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 290339003032 mannonate dehydratase; Provisional; Region: PRK03906 290339003033 mannonate dehydratase; Region: uxuA; TIGR00695 290339003034 elongation factor P; Provisional; Region: PRK04542 290339003035 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 290339003036 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 290339003037 RNA binding site [nucleotide binding]; other site 290339003038 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 290339003039 RNA binding site [nucleotide binding]; other site 290339003040 sugar efflux transporter B; Provisional; Region: PRK15011 290339003041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339003042 putative substrate translocation pore; other site 290339003043 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 290339003044 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 290339003045 active site 290339003046 phosphorylation site [posttranslational modification] 290339003047 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 290339003048 dimerization domain swap beta strand [polypeptide binding]; other site 290339003049 regulatory protein interface [polypeptide binding]; other site 290339003050 active site 290339003051 regulatory phosphorylation site [posttranslational modification]; other site 290339003052 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 290339003053 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 290339003054 putative substrate binding site [chemical binding]; other site 290339003055 putative ATP binding site [chemical binding]; other site 290339003056 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 290339003057 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 290339003058 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 290339003059 active site 290339003060 P-loop; other site 290339003061 phosphorylation site [posttranslational modification] 290339003062 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 290339003063 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 290339003064 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 290339003065 endonuclease IV; Provisional; Region: PRK01060 290339003066 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 290339003067 AP (apurinic/apyrimidinic) site pocket; other site 290339003068 DNA interaction; other site 290339003069 Metal-binding active site; metal-binding site 290339003070 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 290339003071 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 290339003072 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339003073 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 290339003074 putative dimerization interface [polypeptide binding]; other site 290339003075 lysine transporter; Provisional; Region: PRK10836 290339003076 S-formylglutathione hydrolase; Region: PLN02442 290339003077 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 290339003078 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 290339003079 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 290339003080 GTP cyclohydrolase I; Provisional; Region: PLN03044 290339003081 active site 290339003082 Predicted membrane protein [Function unknown]; Region: COG2311 290339003083 hypothetical protein; Provisional; Region: PRK10835 290339003084 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 290339003085 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290339003086 DNA binding site [nucleotide binding] 290339003087 domain linker motif; other site 290339003088 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 290339003089 dimerization interface (closed form) [polypeptide binding]; other site 290339003090 ligand binding site [chemical binding]; other site 290339003091 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 290339003092 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 290339003093 ligand binding site [chemical binding]; other site 290339003094 calcium binding site [ion binding]; other site 290339003095 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 290339003096 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 290339003097 Walker A/P-loop; other site 290339003098 ATP binding site [chemical binding]; other site 290339003099 Q-loop/lid; other site 290339003100 ABC transporter signature motif; other site 290339003101 Walker B; other site 290339003102 D-loop; other site 290339003103 H-loop/switch region; other site 290339003104 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 290339003105 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290339003106 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290339003107 TM-ABC transporter signature motif; other site 290339003108 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 290339003109 putative active site [active] 290339003110 cytidine deaminase; Provisional; Region: PRK09027 290339003111 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 290339003112 active site 290339003113 catalytic motif [active] 290339003114 Zn binding site [ion binding]; other site 290339003115 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 290339003116 active site 290339003117 catalytic motif [active] 290339003118 Zn binding site [ion binding]; other site 290339003119 hypothetical protein; Provisional; Region: PRK10711 290339003120 hypothetical protein; Provisional; Region: PRK01821 290339003121 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 290339003122 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290339003123 non-specific DNA binding site [nucleotide binding]; other site 290339003124 salt bridge; other site 290339003125 sequence-specific DNA binding site [nucleotide binding]; other site 290339003126 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 290339003127 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 290339003128 FMN binding site [chemical binding]; other site 290339003129 active site 290339003130 catalytic residues [active] 290339003131 substrate binding site [chemical binding]; other site 290339003132 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290339003133 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339003134 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 290339003135 putative substrate binding pocket [chemical binding]; other site 290339003136 putative dimerization interface [polypeptide binding]; other site 290339003137 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 290339003138 oxidoreductase; Provisional; Region: PRK12743 290339003139 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290339003140 NAD(P) binding site [chemical binding]; other site 290339003141 active site 290339003142 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 290339003143 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 290339003144 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 290339003145 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 290339003146 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 290339003147 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 290339003148 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290339003149 Coenzyme A binding pocket [chemical binding]; other site 290339003150 D-lactate dehydrogenase; Provisional; Region: PRK11183 290339003151 FAD binding domain; Region: FAD_binding_4; pfam01565 290339003152 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 290339003153 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 290339003154 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 290339003155 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 290339003156 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 290339003157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339003158 dimer interface [polypeptide binding]; other site 290339003159 conserved gate region; other site 290339003160 ABC-ATPase subunit interface; other site 290339003161 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 290339003162 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 290339003163 Walker A/P-loop; other site 290339003164 ATP binding site [chemical binding]; other site 290339003165 Q-loop/lid; other site 290339003166 ABC transporter signature motif; other site 290339003167 Walker B; other site 290339003168 D-loop; other site 290339003169 H-loop/switch region; other site 290339003170 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339003171 putative PBP binding loops; other site 290339003172 ABC-ATPase subunit interface; other site 290339003173 hypothetical protein; Provisional; Region: PRK13681 290339003174 transcriptional regulator MirA; Provisional; Region: PRK15043 290339003175 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 290339003176 DNA binding residues [nucleotide binding] 290339003177 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 290339003178 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 290339003179 active site 290339003180 HIGH motif; other site 290339003181 KMSKS motif; other site 290339003182 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 290339003183 tRNA binding surface [nucleotide binding]; other site 290339003184 anticodon binding site; other site 290339003185 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 290339003186 dimer interface [polypeptide binding]; other site 290339003187 putative tRNA-binding site [nucleotide binding]; other site 290339003188 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 290339003189 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 290339003190 HlyD family secretion protein; Region: HlyD_3; pfam13437 290339003191 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 290339003192 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 290339003193 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 290339003194 FtsX-like permease family; Region: FtsX; pfam02687 290339003195 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 290339003196 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 290339003197 Q-loop/lid; other site 290339003198 ABC transporter signature motif; other site 290339003199 Walker B; other site 290339003200 D-loop; other site 290339003201 H-loop/switch region; other site 290339003202 antiporter inner membrane protein; Provisional; Region: PRK11670 290339003203 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 290339003204 Walker A motif; other site 290339003205 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 290339003206 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290339003207 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 290339003208 Coenzyme A binding pocket [chemical binding]; other site 290339003209 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 290339003210 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 290339003211 GAF domain; Region: GAF_3; pfam13492 290339003212 Histidine kinase; Region: His_kinase; pfam06580 290339003213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290339003214 ATP binding site [chemical binding]; other site 290339003215 Mg2+ binding site [ion binding]; other site 290339003216 G-X-G motif; other site 290339003217 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 290339003218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290339003219 active site 290339003220 phosphorylation site [posttranslational modification] 290339003221 intermolecular recognition site; other site 290339003222 dimerization interface [polypeptide binding]; other site 290339003223 LytTr DNA-binding domain; Region: LytTR; pfam04397 290339003224 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 290339003225 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 290339003226 dimerization interface [polypeptide binding]; other site 290339003227 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 290339003228 dimer interface [polypeptide binding]; other site 290339003229 putative CheW interface [polypeptide binding]; other site 290339003230 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 290339003231 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290339003232 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290339003233 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 290339003234 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 290339003235 TPP riboswitch (THI element) 290339003236 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 290339003237 substrate binding site [chemical binding]; other site 290339003238 multimerization interface [polypeptide binding]; other site 290339003239 ATP binding site [chemical binding]; other site 290339003240 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 290339003241 dimer interface [polypeptide binding]; other site 290339003242 substrate binding site [chemical binding]; other site 290339003243 ATP binding site [chemical binding]; other site 290339003244 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 290339003245 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 290339003246 putative active site; other site 290339003247 catalytic residue [active] 290339003248 lipid kinase; Reviewed; Region: PRK13054 290339003249 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 290339003250 putative protease; Provisional; Region: PRK15452 290339003251 Peptidase family U32; Region: Peptidase_U32; pfam01136 290339003252 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 290339003253 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290339003254 active site 290339003255 phosphorylation site [posttranslational modification] 290339003256 intermolecular recognition site; other site 290339003257 dimerization interface [polypeptide binding]; other site 290339003258 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290339003259 DNA binding site [nucleotide binding] 290339003260 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 290339003261 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290339003262 dimerization interface [polypeptide binding]; other site 290339003263 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290339003264 dimer interface [polypeptide binding]; other site 290339003265 phosphorylation site [posttranslational modification] 290339003266 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290339003267 ATP binding site [chemical binding]; other site 290339003268 Mg2+ binding site [ion binding]; other site 290339003269 G-X-G motif; other site 290339003270 putative transporter; Provisional; Region: PRK10504 290339003271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339003272 putative substrate translocation pore; other site 290339003273 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 290339003274 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 290339003275 Protein export membrane protein; Region: SecD_SecF; cl14618 290339003276 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 290339003277 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 290339003278 HlyD family secretion protein; Region: HlyD_3; pfam13437 290339003279 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 290339003280 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290339003281 salt bridge; other site 290339003282 non-specific DNA binding site [nucleotide binding]; other site 290339003283 sequence-specific DNA binding site [nucleotide binding]; other site 290339003284 putative chaperone; Provisional; Region: PRK11678 290339003285 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 290339003286 nucleotide binding site [chemical binding]; other site 290339003287 putative NEF/HSP70 interaction site [polypeptide binding]; other site 290339003288 SBD interface [polypeptide binding]; other site 290339003289 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 290339003290 AlkA N-terminal domain; Region: AlkA_N; pfam06029 290339003291 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 290339003292 minor groove reading motif; other site 290339003293 helix-hairpin-helix signature motif; other site 290339003294 substrate binding pocket [chemical binding]; other site 290339003295 active site 290339003296 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 290339003297 putative diguanylate cyclase; Provisional; Region: PRK09776 290339003298 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290339003299 putative active site [active] 290339003300 heme pocket [chemical binding]; other site 290339003301 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290339003302 putative active site [active] 290339003303 heme pocket [chemical binding]; other site 290339003304 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290339003305 putative active site [active] 290339003306 heme pocket [chemical binding]; other site 290339003307 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290339003308 metal binding site [ion binding]; metal-binding site 290339003309 active site 290339003310 I-site; other site 290339003311 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 290339003312 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 290339003313 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 290339003314 ATP-binding site [chemical binding]; other site 290339003315 Sugar specificity; other site 290339003316 Pyrimidine base specificity; other site 290339003317 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 290339003318 trimer interface [polypeptide binding]; other site 290339003319 active site 290339003320 putative assembly protein; Provisional; Region: PRK10833 290339003321 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 290339003322 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 290339003323 FOG: CBS domain [General function prediction only]; Region: COG0517 290339003324 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 290339003325 Transporter associated domain; Region: CorC_HlyC; smart01091 290339003326 polysaccharide export protein Wza; Provisional; Region: PRK15078 290339003327 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 290339003328 SLBB domain; Region: SLBB; pfam10531 290339003329 Low molecular weight phosphatase family; Region: LMWPc; cd00115 290339003330 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 290339003331 active site 290339003332 tyrosine kinase; Provisional; Region: PRK11519 290339003333 Chain length determinant protein; Region: Wzz; pfam02706 290339003334 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 290339003335 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 290339003336 colanic acid biosynthesis glycosyl transferase WcaA; Region: WcaA; TIGR04017 290339003337 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290339003338 active site 290339003339 putative acyl transferase; Provisional; Region: PRK10191 290339003340 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 290339003341 trimer interface [polypeptide binding]; other site 290339003342 active site 290339003343 substrate binding site [chemical binding]; other site 290339003344 CoA binding site [chemical binding]; other site 290339003345 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290339003346 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 290339003347 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 290339003348 putative glycosyl transferase; Provisional; Region: PRK10063 290339003349 colanic acid biosynthesis glycosyl transferase WcaE; Region: wcaE; TIGR04009 290339003350 active site 290339003351 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 290339003352 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 290339003353 putative trimer interface [polypeptide binding]; other site 290339003354 putative active site [active] 290339003355 putative substrate binding site [chemical binding]; other site 290339003356 putative CoA binding site [chemical binding]; other site 290339003357 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 290339003358 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 290339003359 NADP-binding site; other site 290339003360 homotetramer interface [polypeptide binding]; other site 290339003361 substrate binding site [chemical binding]; other site 290339003362 homodimer interface [polypeptide binding]; other site 290339003363 active site 290339003364 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 290339003365 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 290339003366 NADP binding site [chemical binding]; other site 290339003367 active site 290339003368 putative substrate binding site [chemical binding]; other site 290339003369 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 290339003370 active site 290339003371 GDP-Mannose binding site [chemical binding]; other site 290339003372 dimer interface [polypeptide binding]; other site 290339003373 modified nudix motif 290339003374 metal binding site [ion binding]; metal-binding site 290339003375 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 290339003376 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 290339003377 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 290339003378 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 290339003379 Substrate binding site; other site 290339003380 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 290339003381 phosphomannomutase CpsG; Provisional; Region: PRK15414 290339003382 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 290339003383 active site 290339003384 substrate binding site [chemical binding]; other site 290339003385 metal binding site [ion binding]; metal-binding site 290339003386 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 290339003387 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 290339003388 colanic acid exporter; Provisional; Region: PRK10459 290339003389 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 290339003390 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 290339003391 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 290339003392 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 290339003393 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 290339003394 putative ADP-binding pocket [chemical binding]; other site 290339003395 colanic acid biosynthesis protein WcaM; Region: WcaM; TIGR04004 290339003396 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 290339003397 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290339003398 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 290339003399 putative NAD(P) binding site [chemical binding]; other site 290339003400 active site 290339003401 putative substrate binding site [chemical binding]; other site 290339003402 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 290339003403 active site 290339003404 tetramer interface; other site 290339003405 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 290339003406 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 290339003407 NAD binding site [chemical binding]; other site 290339003408 substrate binding site [chemical binding]; other site 290339003409 homodimer interface [polypeptide binding]; other site 290339003410 active site 290339003411 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 290339003412 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 290339003413 substrate binding site; other site 290339003414 tetramer interface; other site 290339003415 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 290339003416 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 290339003417 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 290339003418 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 290339003419 inhibitor-cofactor binding pocket; inhibition site 290339003420 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339003421 catalytic residue [active] 290339003422 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 290339003423 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 290339003424 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 290339003425 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290339003426 active site 290339003427 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 290339003428 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 290339003429 active site 290339003430 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 290339003431 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 290339003432 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 290339003433 chain length determinant protein WzzB; Provisional; Region: PRK15471 290339003434 Chain length determinant protein; Region: Wzz; pfam02706 290339003435 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 290339003436 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 290339003437 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 290339003438 metal binding site [ion binding]; metal-binding site 290339003439 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 290339003440 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 290339003441 substrate binding site [chemical binding]; other site 290339003442 glutamase interaction surface [polypeptide binding]; other site 290339003443 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 290339003444 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 290339003445 catalytic residues [active] 290339003446 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 290339003447 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 290339003448 putative active site [active] 290339003449 oxyanion strand; other site 290339003450 catalytic triad [active] 290339003451 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 290339003452 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290339003453 active site 290339003454 motif I; other site 290339003455 motif II; other site 290339003456 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 290339003457 putative active site pocket [active] 290339003458 4-fold oligomerization interface [polypeptide binding]; other site 290339003459 metal binding residues [ion binding]; metal-binding site 290339003460 3-fold/trimer interface [polypeptide binding]; other site 290339003461 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 290339003462 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290339003463 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339003464 homodimer interface [polypeptide binding]; other site 290339003465 catalytic residue [active] 290339003466 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 290339003467 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 290339003468 NAD binding site [chemical binding]; other site 290339003469 dimerization interface [polypeptide binding]; other site 290339003470 product binding site; other site 290339003471 substrate binding site [chemical binding]; other site 290339003472 zinc binding site [ion binding]; other site 290339003473 catalytic residues [active] 290339003474 ATP phosphoribosyltransferase; Region: HisG; cl15266 290339003475 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 290339003476 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 290339003477 histidine operon leader 290339003478 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290339003479 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 290339003480 putative NAD(P) binding site [chemical binding]; other site 290339003481 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 290339003482 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 290339003483 catalytic triad [active] 290339003484 4-aminobutyrate aminotransferase; Provisional; Region: PRK07495 290339003485 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 290339003486 inhibitor-cofactor binding pocket; inhibition site 290339003487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339003488 catalytic residue [active] 290339003489 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 290339003490 exonuclease I; Provisional; Region: sbcB; PRK11779 290339003491 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 290339003492 active site 290339003493 catalytic site [active] 290339003494 substrate binding site [chemical binding]; other site 290339003495 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 290339003496 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 290339003497 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 290339003498 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 290339003499 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 290339003500 DNA gyrase inhibitor; Provisional; Region: PRK10016 290339003501 Predicted membrane protein [Function unknown]; Region: COG1289 290339003502 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 290339003503 hypothetical protein; Provisional; Region: PRK05423 290339003504 MATE family multidrug exporter; Provisional; Region: PRK10189 290339003505 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 290339003506 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 290339003507 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 290339003508 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 290339003509 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 290339003510 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 290339003511 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 290339003512 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 290339003513 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 290339003514 AMP nucleosidase; Provisional; Region: PRK08292 290339003515 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 290339003516 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 290339003517 Sensors of blue-light using FAD; Region: BLUF; smart01034 290339003518 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290339003519 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 290339003520 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 290339003521 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 290339003522 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339003523 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 290339003524 putative dimerization interface [polypeptide binding]; other site 290339003525 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 290339003526 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290339003527 dimerization interface [polypeptide binding]; other site 290339003528 shikimate transporter; Provisional; Region: PRK09952 290339003529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339003530 putative substrate translocation pore; other site 290339003531 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 290339003532 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 290339003533 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290339003534 metal binding site [ion binding]; metal-binding site 290339003535 active site 290339003536 I-site; other site 290339003537 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290339003538 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339003539 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 290339003540 putative effector binding pocket; other site 290339003541 dimerization interface [polypeptide binding]; other site 290339003542 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 290339003543 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 290339003544 potential catalytic triad [active] 290339003545 conserved cys residue [active] 290339003546 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 290339003547 classical (c) SDRs; Region: SDR_c; cd05233 290339003548 NAD(P) binding site [chemical binding]; other site 290339003549 active site 290339003550 DinI-like family; Region: DinI; pfam06183 290339003551 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 290339003552 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 290339003553 trimer interface [polypeptide binding]; other site 290339003554 eyelet of channel; other site 290339003555 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 290339003556 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 290339003557 Zn2+ binding site [ion binding]; other site 290339003558 Mg2+ binding site [ion binding]; other site 290339003559 DNA cytosine methylase; Provisional; Region: PRK10458 290339003560 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 290339003561 cofactor binding site; other site 290339003562 DNA binding site [nucleotide binding] 290339003563 substrate interaction site [chemical binding]; other site 290339003564 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 290339003565 additional DNA contacts [nucleotide binding]; other site 290339003566 mismatch recognition site; other site 290339003567 active site 290339003568 zinc binding site [ion binding]; other site 290339003569 DNA intercalation site [nucleotide binding]; other site 290339003570 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 290339003571 EamA-like transporter family; Region: EamA; pfam00892 290339003572 EamA-like transporter family; Region: EamA; pfam00892 290339003573 hypothetical protein; Provisional; Region: PRK10062 290339003574 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 290339003575 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 290339003576 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290339003577 metal binding site [ion binding]; metal-binding site 290339003578 active site 290339003579 I-site; other site 290339003580 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 290339003581 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290339003582 active site 290339003583 motif I; other site 290339003584 motif II; other site 290339003585 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 290339003586 hypothetical protein; Provisional; Region: PRK10708 290339003587 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 290339003588 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290339003589 DNA binding residues [nucleotide binding] 290339003590 dimerization interface [polypeptide binding]; other site 290339003591 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 290339003592 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 290339003593 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 290339003594 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 290339003595 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 290339003596 flagellar motor switch protein; Validated; Region: fliN; PRK05698 290339003597 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 290339003598 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 290339003599 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 290339003600 flagellar hook-length control protein; Provisional; Region: PRK10118 290339003601 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 290339003602 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 290339003603 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 290339003604 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 290339003605 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 290339003606 Walker A motif/ATP binding site; other site 290339003607 Walker B motif; other site 290339003608 flagellar assembly protein H; Validated; Region: fliH; PRK05687 290339003609 Flagellar assembly protein FliH; Region: FliH; pfam02108 290339003610 flagellar motor switch protein FliG; Region: fliG; TIGR00207 290339003611 FliG C-terminal domain; Region: FliG_C; pfam01706 290339003612 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 290339003613 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 290339003614 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 290339003615 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 290339003616 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 290339003617 Catalytic site [active] 290339003618 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 290339003619 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 290339003620 active site 290339003621 DNA binding site [nucleotide binding] 290339003622 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 290339003623 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 290339003624 active site 290339003625 DNA binding site [nucleotide binding] 290339003626 Int/Topo IB signature motif; other site 290339003627 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 290339003628 Uncharacterized protein conserved in bacteria (DUF2251); Region: DUF2251; pfam10008 290339003629 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 290339003630 Helix-turn-helix domain; Region: HTH_31; pfam13560 290339003631 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 290339003632 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290339003633 putative NAD(P) binding site [chemical binding]; other site 290339003634 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 290339003635 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 290339003636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339003637 putative substrate translocation pore; other site 290339003638 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339003639 transcriptional activator TtdR; Provisional; Region: PRK09801 290339003640 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 290339003641 putative effector binding pocket; other site 290339003642 dimerization interface [polypeptide binding]; other site 290339003643 Methyltransferase domain; Region: Methyltransf_23; pfam13489 290339003644 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290339003645 S-adenosylmethionine binding site [chemical binding]; other site 290339003646 hypothetical protein; Provisional; Region: PRK09951 290339003647 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 290339003648 CPxP motif; other site 290339003649 putative inner membrane protein; Provisional; Region: PRK11099 290339003650 lipoprotein; Provisional; Region: PRK10397 290339003651 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 290339003652 flagellar protein FliS; Validated; Region: fliS; PRK05685 290339003653 flagellar capping protein; Reviewed; Region: fliD; PRK08032 290339003654 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 290339003655 flagellin; Provisional; Region: PRK12802 290339003656 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 290339003657 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 290339003658 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290339003659 S-adenosylmethionine binding site [chemical binding]; other site 290339003660 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 290339003661 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290339003662 binding surface 290339003663 TPR motif; other site 290339003664 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 290339003665 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290339003666 binding surface 290339003667 TPR motif; other site 290339003668 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 290339003669 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 290339003670 inhibitor-cofactor binding pocket; inhibition site 290339003671 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339003672 catalytic residue [active] 290339003673 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 290339003674 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 290339003675 putative trimer interface [polypeptide binding]; other site 290339003676 putative CoA binding site [chemical binding]; other site 290339003677 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 290339003678 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290339003679 NAD(P) binding site [chemical binding]; other site 290339003680 active site 290339003681 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 290339003682 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290339003683 NAD(P) binding site [chemical binding]; other site 290339003684 active site 290339003685 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 290339003686 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 290339003687 AMP binding site [chemical binding]; other site 290339003688 active site 290339003689 acyl-activating enzyme (AAE) consensus motif; other site 290339003690 CoA binding site [chemical binding]; other site 290339003691 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 290339003692 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 290339003693 NAD(P) binding site [chemical binding]; other site 290339003694 catalytic residues [active] 290339003695 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 290339003696 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290339003697 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 290339003698 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290339003699 DNA binding residues [nucleotide binding] 290339003700 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 290339003701 cystine transporter subunit; Provisional; Region: PRK11260 290339003702 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290339003703 substrate binding pocket [chemical binding]; other site 290339003704 membrane-bound complex binding site; other site 290339003705 hinge residues; other site 290339003706 D-cysteine desulfhydrase; Validated; Region: PRK03910 290339003707 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 290339003708 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339003709 catalytic residue [active] 290339003710 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 290339003711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339003712 dimer interface [polypeptide binding]; other site 290339003713 conserved gate region; other site 290339003714 putative PBP binding loops; other site 290339003715 ABC-ATPase subunit interface; other site 290339003716 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 290339003717 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 290339003718 Walker A/P-loop; other site 290339003719 ATP binding site [chemical binding]; other site 290339003720 Q-loop/lid; other site 290339003721 ABC transporter signature motif; other site 290339003722 Walker B; other site 290339003723 D-loop; other site 290339003724 H-loop/switch region; other site 290339003725 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 290339003726 Autoinducer binding domain; Region: Autoind_bind; pfam03472 290339003727 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290339003728 DNA binding residues [nucleotide binding] 290339003729 dimerization interface [polypeptide binding]; other site 290339003730 hypothetical protein; Provisional; Region: PRK10613 290339003731 response regulator; Provisional; Region: PRK09483 290339003732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290339003733 active site 290339003734 phosphorylation site [posttranslational modification] 290339003735 intermolecular recognition site; other site 290339003736 dimerization interface [polypeptide binding]; other site 290339003737 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290339003738 DNA binding residues [nucleotide binding] 290339003739 dimerization interface [polypeptide binding]; other site 290339003740 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 290339003741 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 290339003742 GIY-YIG motif/motif A; other site 290339003743 active site 290339003744 catalytic site [active] 290339003745 putative DNA binding site [nucleotide binding]; other site 290339003746 metal binding site [ion binding]; metal-binding site 290339003747 UvrB/uvrC motif; Region: UVR; pfam02151 290339003748 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 290339003749 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 290339003750 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290339003751 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 290339003752 Coenzyme A binding pocket [chemical binding]; other site 290339003753 tyrosine transporter TyrP; Provisional; Region: PRK15132 290339003754 aromatic amino acid transport protein; Region: araaP; TIGR00837 290339003755 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 290339003756 Ferritin-like domain; Region: Ferritin; pfam00210 290339003757 ferroxidase diiron center [ion binding]; other site 290339003758 YecR-like lipoprotein; Region: YecR; pfam13992 290339003759 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 290339003760 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 290339003761 dimer interface [polypeptide binding]; other site 290339003762 putative CheW interface [polypeptide binding]; other site 290339003763 hypothetical protein; Provisional; Region: PRK09273 290339003764 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 290339003765 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 290339003766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339003767 putative transporter; Provisional; Region: PRK10504 290339003768 putative substrate translocation pore; other site 290339003769 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 290339003770 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 290339003771 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 290339003772 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 290339003773 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290339003774 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 290339003775 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 290339003776 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 290339003777 Ferritin-like domain; Region: Ferritin; pfam00210 290339003778 ferroxidase diiron center [ion binding]; other site 290339003779 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 290339003780 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 290339003781 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 290339003782 ligand binding site [chemical binding]; other site 290339003783 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 290339003784 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 290339003785 Walker A/P-loop; other site 290339003786 ATP binding site [chemical binding]; other site 290339003787 Q-loop/lid; other site 290339003788 ABC transporter signature motif; other site 290339003789 Walker B; other site 290339003790 D-loop; other site 290339003791 H-loop/switch region; other site 290339003792 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 290339003793 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290339003794 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290339003795 TM-ABC transporter signature motif; other site 290339003796 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 290339003797 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290339003798 active site 290339003799 motif I; other site 290339003800 motif II; other site 290339003801 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 290339003802 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 290339003803 active site 290339003804 homotetramer interface [polypeptide binding]; other site 290339003805 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290339003806 Ligand Binding Site [chemical binding]; other site 290339003807 transcriptional activator FlhD; Provisional; Region: PRK02909 290339003808 transcriptional activator FlhC; Provisional; Region: PRK12722 290339003809 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 290339003810 flagellar motor protein MotA; Validated; Region: PRK09110 290339003811 flagellar motor protein MotB; Validated; Region: motB; PRK09041 290339003812 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 290339003813 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 290339003814 ligand binding site [chemical binding]; other site 290339003815 chemotaxis protein CheA; Provisional; Region: PRK10547 290339003816 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 290339003817 putative binding surface; other site 290339003818 active site 290339003819 CheY binding; Region: CheY-binding; pfam09078 290339003820 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 290339003821 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290339003822 ATP binding site [chemical binding]; other site 290339003823 Mg2+ binding site [ion binding]; other site 290339003824 G-X-G motif; other site 290339003825 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 290339003826 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 290339003827 putative CheA interaction surface; other site 290339003828 Spore Coat Protein U domain; Region: SCPU; pfam05229 290339003829 Spore Coat Protein U domain; Region: SCPU; pfam05229 290339003830 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 290339003831 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 290339003832 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 290339003833 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 290339003834 PapC C-terminal domain; Region: PapC_C; pfam13953 290339003835 Spore Coat Protein U domain; Region: SCPU; pfam05229 290339003836 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 290339003837 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 290339003838 dimer interface [polypeptide binding]; other site 290339003839 ligand binding site [chemical binding]; other site 290339003840 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290339003841 dimerization interface [polypeptide binding]; other site 290339003842 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 290339003843 dimer interface [polypeptide binding]; other site 290339003844 putative CheW interface [polypeptide binding]; other site 290339003845 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 290339003846 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 290339003847 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290339003848 S-adenosylmethionine binding site [chemical binding]; other site 290339003849 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 290339003850 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290339003851 active site 290339003852 phosphorylation site [posttranslational modification] 290339003853 intermolecular recognition site; other site 290339003854 dimerization interface [polypeptide binding]; other site 290339003855 CheB methylesterase; Region: CheB_methylest; pfam01339 290339003856 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 290339003857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290339003858 active site 290339003859 phosphorylation site [posttranslational modification] 290339003860 intermolecular recognition site; other site 290339003861 dimerization interface [polypeptide binding]; other site 290339003862 chemotaxis regulator CheZ; Provisional; Region: PRK11166 290339003863 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 290339003864 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 290339003865 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 290339003866 FHIPEP family; Region: FHIPEP; pfam00771 290339003867 Flagellar protein FlhE; Region: FlhE; pfam06366 290339003868 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 290339003869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339003870 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 290339003871 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 290339003872 ligand binding site [chemical binding]; other site 290339003873 flexible hinge region; other site 290339003874 Transcriptional regulator; Region: Rrf2; cl17282 290339003875 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 290339003876 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 290339003877 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 290339003878 active site 290339003879 HIGH motif; other site 290339003880 KMSK motif region; other site 290339003881 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 290339003882 tRNA binding surface [nucleotide binding]; other site 290339003883 anticodon binding site; other site 290339003884 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 290339003885 putative metal binding site [ion binding]; other site 290339003886 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 290339003887 putative hydrophobic ligand binding site [chemical binding]; other site 290339003888 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 290339003889 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 290339003890 NAD binding site [chemical binding]; other site 290339003891 catalytic Zn binding site [ion binding]; other site 290339003892 structural Zn binding site [ion binding]; other site 290339003893 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290339003894 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 290339003895 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339003896 homodimer interface [polypeptide binding]; other site 290339003897 catalytic residue [active] 290339003898 copper homeostasis protein CutC; Provisional; Region: PRK11572 290339003899 NAD-specific glutamate dehydrogenase; Region: NAD-GH; pfam10712 290339003900 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 290339003901 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 290339003902 nucleotide binding site [chemical binding]; other site 290339003903 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 290339003904 HSP70 interaction site [polypeptide binding]; other site 290339003905 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 290339003906 BON domain; Region: BON; pfam04972 290339003907 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 290339003908 Methyltransferase domain; Region: Methyltransf_23; pfam13489 290339003909 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290339003910 S-adenosylmethionine binding site [chemical binding]; other site 290339003911 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 290339003912 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290339003913 S-adenosylmethionine binding site [chemical binding]; other site 290339003914 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 290339003915 hypothetical protein; Provisional; Region: PRK10302 290339003916 Isochorismatase family; Region: Isochorismatase; pfam00857 290339003917 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 290339003918 catalytic triad [active] 290339003919 conserved cis-peptide bond; other site 290339003920 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 290339003921 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 290339003922 dimer interface [polypeptide binding]; other site 290339003923 anticodon binding site; other site 290339003924 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 290339003925 homodimer interface [polypeptide binding]; other site 290339003926 motif 1; other site 290339003927 active site 290339003928 motif 2; other site 290339003929 GAD domain; Region: GAD; pfam02938 290339003930 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 290339003931 active site 290339003932 motif 3; other site 290339003933 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 290339003934 nudix motif; other site 290339003935 hypothetical protein; Validated; Region: PRK00110 290339003936 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 290339003937 active site 290339003938 putative DNA-binding cleft [nucleotide binding]; other site 290339003939 dimer interface [polypeptide binding]; other site 290339003940 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 290339003941 RuvA N terminal domain; Region: RuvA_N; pfam01330 290339003942 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 290339003943 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 290339003944 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290339003945 Walker A motif; other site 290339003946 ATP binding site [chemical binding]; other site 290339003947 Walker B motif; other site 290339003948 arginine finger; other site 290339003949 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 290339003950 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 290339003951 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290339003952 ABC-ATPase subunit interface; other site 290339003953 dimer interface [polypeptide binding]; other site 290339003954 putative PBP binding regions; other site 290339003955 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 290339003956 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 290339003957 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 290339003958 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 290339003959 metal binding site [ion binding]; metal-binding site 290339003960 putative peptidase; Provisional; Region: PRK11649 290339003961 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 290339003962 Peptidase family M23; Region: Peptidase_M23; pfam01551 290339003963 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 290339003964 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 290339003965 putative acyl-acceptor binding pocket; other site 290339003966 pyruvate kinase; Provisional; Region: PRK05826 290339003967 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 290339003968 domain interfaces; other site 290339003969 active site 290339003970 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 290339003971 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 290339003972 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 290339003973 putative active site [active] 290339003974 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 290339003975 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 290339003976 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 290339003977 phosphogluconate dehydratase; Validated; Region: PRK09054 290339003978 6-phosphogluconate dehydratase; Region: edd; TIGR01196 290339003979 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 290339003980 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 290339003981 active site 290339003982 intersubunit interface [polypeptide binding]; other site 290339003983 catalytic residue [active] 290339003984 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 290339003985 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290339003986 ATP-grasp domain; Region: ATP-grasp; pfam02222 290339003987 YebG protein; Region: YebG; pfam07130 290339003988 hypothetical protein; Provisional; Region: PRK13680 290339003989 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 290339003990 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 290339003991 putative metal binding site [ion binding]; other site 290339003992 protease 2; Provisional; Region: PRK10115 290339003993 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 290339003994 exodeoxyribonuclease X; Provisional; Region: PRK07983 290339003995 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 290339003996 active site 290339003997 catalytic site [active] 290339003998 substrate binding site [chemical binding]; other site 290339003999 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 290339004000 CopC domain; Region: CopC; cl01012 290339004001 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 290339004002 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 290339004003 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 290339004004 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 290339004005 active site 290339004006 metal binding site [ion binding]; metal-binding site 290339004007 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 290339004008 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 290339004009 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 290339004010 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290339004011 S-adenosylmethionine binding site [chemical binding]; other site 290339004012 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 290339004013 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 290339004014 mce related protein; Region: MCE; pfam02470 290339004015 mce related protein; Region: MCE; pfam02470 290339004016 mce related protein; Region: MCE; pfam02470 290339004017 mce related protein; Region: MCE; pfam02470 290339004018 mce related protein; Region: MCE; pfam02470 290339004019 mce related protein; Region: MCE; pfam02470 290339004020 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 290339004021 Paraquat-inducible protein A; Region: PqiA; pfam04403 290339004022 Paraquat-inducible protein A; Region: PqiA; pfam04403 290339004023 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 290339004024 GAF domain; Region: GAF_2; pfam13185 290339004025 ProP expression regulator; Provisional; Region: PRK04950 290339004026 ProQ/FINO family; Region: ProQ; pfam04352 290339004027 carboxy-terminal protease; Provisional; Region: PRK11186 290339004028 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 290339004029 protein binding site [polypeptide binding]; other site 290339004030 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 290339004031 Catalytic dyad [active] 290339004032 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 290339004033 heat shock protein HtpX; Provisional; Region: PRK05457 290339004034 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 290339004035 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290339004036 putative DNA binding site [nucleotide binding]; other site 290339004037 putative Zn2+ binding site [ion binding]; other site 290339004038 Bacterial transcriptional regulator; Region: IclR; pfam01614 290339004039 YobH-like protein; Region: YobH; pfam13996 290339004040 PhoPQ regulatory protein; Provisional; Region: PRK10299 290339004041 YebO-like protein; Region: YebO; pfam13974 290339004042 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 290339004043 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 290339004044 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 290339004045 DNA-binding site [nucleotide binding]; DNA binding site 290339004046 RNA-binding motif; other site 290339004047 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 290339004048 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290339004049 S-adenosylmethionine binding site [chemical binding]; other site 290339004050 hypothetical protein; Provisional; Region: PRK11469 290339004051 Domain of unknown function DUF; Region: DUF204; pfam02659 290339004052 Domain of unknown function DUF; Region: DUF204; pfam02659 290339004053 yybp-ykoy leader 290339004054 hypothetical protein; Provisional; Region: PRK02913 290339004055 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 290339004056 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 290339004057 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 290339004058 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 290339004059 active pocket/dimerization site; other site 290339004060 active site 290339004061 phosphorylation site [posttranslational modification] 290339004062 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 290339004063 active site 290339004064 phosphorylation site [posttranslational modification] 290339004065 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 290339004066 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 290339004067 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 290339004068 Transporter associated domain; Region: CorC_HlyC; smart01091 290339004069 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 290339004070 phage resistance protein; Provisional; Region: PRK10551 290339004071 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290339004072 L-serine deaminase; Provisional; Region: PRK15023 290339004073 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 290339004074 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 290339004075 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 290339004076 putative active site [active] 290339004077 putative CoA binding site [chemical binding]; other site 290339004078 nudix motif; other site 290339004079 metal binding site [ion binding]; metal-binding site 290339004080 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 290339004081 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 290339004082 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 290339004083 hypothetical protein; Provisional; Region: PRK05114 290339004084 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 290339004085 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 290339004086 dimer interface [polypeptide binding]; other site 290339004087 active site 290339004088 CoA binding pocket [chemical binding]; other site 290339004089 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290339004090 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290339004091 NAD(P) binding site [chemical binding]; other site 290339004092 active site 290339004093 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 290339004094 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 290339004095 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 290339004096 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 290339004097 active site 290339004098 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 290339004099 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 290339004100 Fatty acid desaturase; Region: FA_desaturase; pfam00487 290339004101 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 290339004102 putative di-iron ligands [ion binding]; other site 290339004103 Fatty acid desaturase; Region: FA_desaturase; pfam00487 290339004104 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 290339004105 putative di-iron ligands [ion binding]; other site 290339004106 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 290339004107 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 290339004108 homotrimer interaction site [polypeptide binding]; other site 290339004109 putative active site [active] 290339004110 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 290339004111 DEAD/DEAH box helicase; Region: DEAD; pfam00270 290339004112 ATP binding site [chemical binding]; other site 290339004113 DEAD_2; Region: DEAD_2; pfam06733 290339004114 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 290339004115 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 290339004116 Glycoprotease family; Region: Peptidase_M22; pfam00814 290339004117 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 290339004118 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 290339004119 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 290339004120 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 290339004121 acyl-activating enzyme (AAE) consensus motif; other site 290339004122 putative AMP binding site [chemical binding]; other site 290339004123 putative active site [active] 290339004124 putative CoA binding site [chemical binding]; other site 290339004125 ribonuclease D; Provisional; Region: PRK10829 290339004126 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 290339004127 catalytic site [active] 290339004128 putative active site [active] 290339004129 putative substrate binding site [chemical binding]; other site 290339004130 HRDC domain; Region: HRDC; pfam00570 290339004131 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 290339004132 cell division inhibitor MinD; Provisional; Region: PRK10818 290339004133 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 290339004134 Switch I; other site 290339004135 Switch II; other site 290339004136 septum formation inhibitor; Reviewed; Region: minC; PRK03511 290339004137 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 290339004138 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 290339004139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 290339004140 hypothetical protein; Provisional; Region: PRK10691 290339004141 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 290339004142 hypothetical protein; Provisional; Region: PRK05170 290339004143 disulfide bond formation protein B; Provisional; Region: PRK01749 290339004144 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 290339004145 transmembrane helices; other site 290339004146 fatty acid metabolism regulator; Provisional; Region: PRK04984 290339004147 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290339004148 DNA-binding site [nucleotide binding]; DNA binding site 290339004149 FadR C-terminal domain; Region: FadR_C; pfam07840 290339004150 SpoVR family protein; Provisional; Region: PRK11767 290339004151 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 290339004152 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 290339004153 hydroxyglutarate oxidase; Provisional; Region: PRK11728 290339004154 alanine racemase; Reviewed; Region: dadX; PRK03646 290339004155 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 290339004156 active site 290339004157 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 290339004158 substrate binding site [chemical binding]; other site 290339004159 catalytic residues [active] 290339004160 dimer interface [polypeptide binding]; other site 290339004161 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 290339004162 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 290339004163 TrkA-C domain; Region: TrkA_C; pfam02080 290339004164 Transporter associated domain; Region: CorC_HlyC; smart01091 290339004165 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 290339004166 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 290339004167 dimer interface [polypeptide binding]; other site 290339004168 catalytic triad [active] 290339004169 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 290339004170 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 290339004171 N-acetyl-D-glucosamine binding site [chemical binding]; other site 290339004172 catalytic residue [active] 290339004173 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 290339004174 Flagellar regulator YcgR; Region: YcgR; pfam07317 290339004175 PilZ domain; Region: PilZ; pfam07238 290339004176 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 290339004177 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 290339004178 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 290339004179 N-terminal plug; other site 290339004180 ligand-binding site [chemical binding]; other site 290339004181 trehalase; Provisional; Region: treA; PRK13271 290339004182 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 290339004183 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 290339004184 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290339004185 DNA-binding site [nucleotide binding]; DNA binding site 290339004186 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290339004187 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339004188 homodimer interface [polypeptide binding]; other site 290339004189 catalytic residue [active] 290339004190 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 290339004191 Uncharacterized conserved protein [Function unknown]; Region: COG2128 290339004192 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 290339004193 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 290339004194 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 290339004195 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 290339004196 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290339004197 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290339004198 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 290339004199 hypothetical protein; Provisional; Region: PRK10396 290339004200 yecA family protein; Region: ygfB_yecA; TIGR02292 290339004201 SEC-C motif; Region: SEC-C; pfam02810 290339004202 GTP-binding protein YchF; Reviewed; Region: PRK09601 290339004203 YchF GTPase; Region: YchF; cd01900 290339004204 G1 box; other site 290339004205 GTP/Mg2+ binding site [chemical binding]; other site 290339004206 Switch I region; other site 290339004207 G2 box; other site 290339004208 Switch II region; other site 290339004209 G3 box; other site 290339004210 G4 box; other site 290339004211 G5 box; other site 290339004212 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 290339004213 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 290339004214 putative active site [active] 290339004215 catalytic residue [active] 290339004216 hypothetical protein; Provisional; Region: PRK10692 290339004217 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 290339004218 DNA binding residues [nucleotide binding] 290339004219 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 290339004220 putative dimer interface [polypeptide binding]; other site 290339004221 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 290339004222 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 290339004223 putative transporter; Provisional; Region: PRK11660 290339004224 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 290339004225 Sulfate transporter family; Region: Sulfate_transp; pfam00916 290339004226 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 290339004227 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 290339004228 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 290339004229 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290339004230 active site 290339004231 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 290339004232 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 290339004233 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 290339004234 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 290339004235 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 290339004236 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 290339004237 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 290339004238 tRNA; other site 290339004239 putative tRNA binding site [nucleotide binding]; other site 290339004240 putative NADP binding site [chemical binding]; other site 290339004241 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 290339004242 peptide chain release factor 1; Validated; Region: prfA; PRK00591 290339004243 This domain is found in peptide chain release factors; Region: PCRF; smart00937 290339004244 RF-1 domain; Region: RF-1; pfam00472 290339004245 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 290339004246 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290339004247 Invasion gene expression up-regulator, SirB; Region: SirB; cl01184 290339004248 hypothetical protein; Provisional; Region: PRK10941 290339004249 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 290339004250 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 290339004251 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 290339004252 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 290339004253 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 290339004254 cation transport regulator; Reviewed; Region: chaB; PRK09582 290339004255 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 290339004256 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 290339004257 putative active site pocket [active] 290339004258 dimerization interface [polypeptide binding]; other site 290339004259 putative catalytic residue [active] 290339004260 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 290339004261 Cache domain; Region: Cache_1; pfam02743 290339004262 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 290339004263 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290339004264 dimerization interface [polypeptide binding]; other site 290339004265 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 290339004266 dimer interface [polypeptide binding]; other site 290339004267 putative CheW interface [polypeptide binding]; other site 290339004268 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 290339004269 Nitrate and nitrite sensing; Region: NIT; pfam08376 290339004270 ANTAR domain; Region: ANTAR; pfam03861 290339004271 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 290339004272 NMT1-like family; Region: NMT1_2; pfam13379 290339004273 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 290339004274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339004275 dimer interface [polypeptide binding]; other site 290339004276 conserved gate region; other site 290339004277 putative PBP binding loops; other site 290339004278 ABC-ATPase subunit interface; other site 290339004279 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 290339004280 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 290339004281 Walker A/P-loop; other site 290339004282 ATP binding site [chemical binding]; other site 290339004283 Q-loop/lid; other site 290339004284 ABC transporter signature motif; other site 290339004285 Walker B; other site 290339004286 D-loop; other site 290339004287 H-loop/switch region; other site 290339004288 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 290339004289 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290339004290 nitrite reductase subunit NirD; Provisional; Region: PRK14989 290339004291 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290339004292 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290339004293 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 290339004294 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 290339004295 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 290339004296 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 290339004297 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 290339004298 [4Fe-4S] binding site [ion binding]; other site 290339004299 molybdopterin cofactor binding site; other site 290339004300 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 290339004301 molybdopterin cofactor binding site; other site 290339004302 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 290339004303 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 290339004304 substrate binding site [chemical binding]; other site 290339004305 putative invasin; Provisional; Region: PRK10177 290339004306 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 290339004307 transcriptional regulator NarL; Provisional; Region: PRK10651 290339004308 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290339004309 active site 290339004310 phosphorylation site [posttranslational modification] 290339004311 intermolecular recognition site; other site 290339004312 dimerization interface [polypeptide binding]; other site 290339004313 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290339004314 DNA binding residues [nucleotide binding] 290339004315 dimerization interface [polypeptide binding]; other site 290339004316 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 290339004317 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 290339004318 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290339004319 dimerization interface [polypeptide binding]; other site 290339004320 Histidine kinase; Region: HisKA_3; pfam07730 290339004321 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290339004322 ATP binding site [chemical binding]; other site 290339004323 Mg2+ binding site [ion binding]; other site 290339004324 G-X-G motif; other site 290339004325 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 290339004326 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 290339004327 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 290339004328 [4Fe-4S] binding site [ion binding]; other site 290339004329 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 290339004330 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 290339004331 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 290339004332 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 290339004333 molybdopterin cofactor binding site; other site 290339004334 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 290339004335 4Fe-4S binding domain; Region: Fer4; cl02805 290339004336 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 290339004337 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 290339004338 Cupin; Region: Cupin_6; pfam12852 290339004339 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290339004340 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 290339004341 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290339004342 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 290339004343 NADP binding site [chemical binding]; other site 290339004344 active site 290339004345 steroid binding site; other site 290339004346 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 290339004347 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 290339004348 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 290339004349 putative active site [active] 290339004350 putative substrate binding site [chemical binding]; other site 290339004351 putative cosubstrate binding site; other site 290339004352 catalytic site [active] 290339004353 hypothetical protein; Provisional; Region: PRK01617 290339004354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290339004355 active site 290339004356 response regulator of RpoS; Provisional; Region: PRK10693 290339004357 phosphorylation site [posttranslational modification] 290339004358 intermolecular recognition site; other site 290339004359 dimerization interface [polypeptide binding]; other site 290339004360 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 290339004361 active site 290339004362 tetramer interface; other site 290339004363 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 290339004364 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 290339004365 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 290339004366 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 290339004367 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290339004368 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 290339004369 putative NAD(P) binding site [chemical binding]; other site 290339004370 active site 290339004371 putative substrate binding site [chemical binding]; other site 290339004372 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 290339004373 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 290339004374 thymidine kinase; Provisional; Region: PRK04296 290339004375 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 290339004376 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 290339004377 putative catalytic cysteine [active] 290339004378 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 290339004379 putative active site [active] 290339004380 metal binding site [ion binding]; metal-binding site 290339004381 hypothetical protein; Provisional; Region: PRK11111 290339004382 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 290339004383 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 290339004384 peptide binding site [polypeptide binding]; other site 290339004385 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 290339004386 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339004387 dimer interface [polypeptide binding]; other site 290339004388 conserved gate region; other site 290339004389 putative PBP binding loops; other site 290339004390 ABC-ATPase subunit interface; other site 290339004391 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 290339004392 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 290339004393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339004394 dimer interface [polypeptide binding]; other site 290339004395 conserved gate region; other site 290339004396 putative PBP binding loops; other site 290339004397 ABC-ATPase subunit interface; other site 290339004398 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 290339004399 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290339004400 Walker A/P-loop; other site 290339004401 ATP binding site [chemical binding]; other site 290339004402 Q-loop/lid; other site 290339004403 ABC transporter signature motif; other site 290339004404 Walker B; other site 290339004405 D-loop; other site 290339004406 H-loop/switch region; other site 290339004407 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 290339004408 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 290339004409 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290339004410 Walker A/P-loop; other site 290339004411 ATP binding site [chemical binding]; other site 290339004412 Q-loop/lid; other site 290339004413 ABC transporter signature motif; other site 290339004414 Walker B; other site 290339004415 D-loop; other site 290339004416 H-loop/switch region; other site 290339004417 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 290339004418 Ion transport protein; Region: Ion_trans; pfam00520 290339004419 Ion channel; Region: Ion_trans_2; pfam07885 290339004420 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 290339004421 Double zinc ribbon; Region: DZR; pfam12773 290339004422 dsDNA-mimic protein; Reviewed; Region: PRK05094 290339004423 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 290339004424 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 290339004425 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 290339004426 putative active site [active] 290339004427 catalytic site [active] 290339004428 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 290339004429 putative active site [active] 290339004430 catalytic site [active] 290339004431 YciI-like protein; Reviewed; Region: PRK11370 290339004432 transport protein TonB; Provisional; Region: PRK10819 290339004433 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 290339004434 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 290339004435 outer membrane receptor FepA; Provisional; Region: PRK13528 290339004436 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 290339004437 N-terminal plug; other site 290339004438 ligand-binding site [chemical binding]; other site 290339004439 intracellular septation protein A; Reviewed; Region: PRK00259 290339004440 hypothetical protein; Provisional; Region: PRK02868 290339004441 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 290339004442 outer membrane protein W; Provisional; Region: PRK10959 290339004443 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 290339004444 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 290339004445 substrate binding site [chemical binding]; other site 290339004446 active site 290339004447 catalytic residues [active] 290339004448 heterodimer interface [polypeptide binding]; other site 290339004449 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 290339004450 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 290339004451 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339004452 catalytic residue [active] 290339004453 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 290339004454 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 290339004455 active site 290339004456 ribulose/triose binding site [chemical binding]; other site 290339004457 phosphate binding site [ion binding]; other site 290339004458 substrate (anthranilate) binding pocket [chemical binding]; other site 290339004459 product (indole) binding pocket [chemical binding]; other site 290339004460 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 290339004461 active site 290339004462 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 290339004463 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 290339004464 glutamine binding [chemical binding]; other site 290339004465 catalytic triad [active] 290339004466 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 290339004467 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 290339004468 anthranilate synthase component I; Provisional; Region: PRK13564 290339004469 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 290339004470 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 290339004471 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 290339004472 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 290339004473 active site 290339004474 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 290339004475 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 290339004476 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 290339004477 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 290339004478 RNA binding surface [nucleotide binding]; other site 290339004479 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 290339004480 probable active site [active] 290339004481 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 290339004482 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 290339004483 homodimer interface [polypeptide binding]; other site 290339004484 Walker A motif; other site 290339004485 ATP binding site [chemical binding]; other site 290339004486 hydroxycobalamin binding site [chemical binding]; other site 290339004487 Walker B motif; other site 290339004488 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 290339004489 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 290339004490 NADP binding site [chemical binding]; other site 290339004491 homodimer interface [polypeptide binding]; other site 290339004492 active site 290339004493 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 290339004494 putative inner membrane peptidase; Provisional; Region: PRK11778 290339004495 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 290339004496 tandem repeat interface [polypeptide binding]; other site 290339004497 oligomer interface [polypeptide binding]; other site 290339004498 active site residues [active] 290339004499 hypothetical protein; Provisional; Region: PRK11037 290339004500 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 290339004501 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 290339004502 active site 290339004503 interdomain interaction site; other site 290339004504 putative metal-binding site [ion binding]; other site 290339004505 nucleotide binding site [chemical binding]; other site 290339004506 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 290339004507 domain I; other site 290339004508 DNA binding groove [nucleotide binding] 290339004509 phosphate binding site [ion binding]; other site 290339004510 domain II; other site 290339004511 domain III; other site 290339004512 nucleotide binding site [chemical binding]; other site 290339004513 catalytic site [active] 290339004514 domain IV; other site 290339004515 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 290339004516 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 290339004517 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 290339004518 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 290339004519 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 290339004520 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339004521 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 290339004522 substrate binding site [chemical binding]; other site 290339004523 putative dimerization interface [polypeptide binding]; other site 290339004524 aconitate hydratase; Validated; Region: PRK09277 290339004525 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 290339004526 substrate binding site [chemical binding]; other site 290339004527 ligand binding site [chemical binding]; other site 290339004528 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 290339004529 substrate binding site [chemical binding]; other site 290339004530 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 290339004531 dimerization interface [polypeptide binding]; other site 290339004532 active site 290339004533 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 290339004534 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 290339004535 active site 290339004536 Predicted membrane protein [Function unknown]; Region: COG3771 290339004537 tetratricopeptide repeat protein; Provisional; Region: PRK11788 290339004538 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 290339004539 TPR motif; other site 290339004540 binding surface 290339004541 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290339004542 binding surface 290339004543 TPR motif; other site 290339004544 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 290339004545 TPR motif; other site 290339004546 binding surface 290339004547 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 290339004548 active site 290339004549 dimer interface [polypeptide binding]; other site 290339004550 translation initiation factor Sui1; Validated; Region: PRK06824 290339004551 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 290339004552 putative rRNA binding site [nucleotide binding]; other site 290339004553 lipoprotein; Provisional; Region: PRK10540 290339004554 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 290339004555 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 290339004556 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 290339004557 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 290339004558 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 290339004559 dimer interface [polypeptide binding]; other site 290339004560 active site 290339004561 glycine loop; other site 290339004562 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 290339004563 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290339004564 FeS/SAM binding site; other site 290339004565 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 290339004566 active site 290339004567 intersubunit interactions; other site 290339004568 catalytic residue [active] 290339004569 hypothetical protein; Provisional; Region: PRK13658 290339004570 enoyl-CoA hydratase; Validated; Region: PRK08788 290339004571 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 290339004572 substrate binding site [chemical binding]; other site 290339004573 oxyanion hole (OAH) forming residues; other site 290339004574 trimer interface [polypeptide binding]; other site 290339004575 RNase II stability modulator; Provisional; Region: PRK10060 290339004576 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290339004577 putative active site [active] 290339004578 heme pocket [chemical binding]; other site 290339004579 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290339004580 metal binding site [ion binding]; metal-binding site 290339004581 active site 290339004582 I-site; other site 290339004583 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290339004584 exoribonuclease II; Provisional; Region: PRK05054 290339004585 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 290339004586 RNB domain; Region: RNB; pfam00773 290339004587 S1 RNA binding domain; Region: S1; pfam00575 290339004588 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 290339004589 Uncharacterized conserved protein [Function unknown]; Region: COG2128 290339004590 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 290339004591 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 290339004592 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 290339004593 NAD binding site [chemical binding]; other site 290339004594 homotetramer interface [polypeptide binding]; other site 290339004595 homodimer interface [polypeptide binding]; other site 290339004596 substrate binding site [chemical binding]; other site 290339004597 active site 290339004598 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 290339004599 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290339004600 Walker A/P-loop; other site 290339004601 ATP binding site [chemical binding]; other site 290339004602 Q-loop/lid; other site 290339004603 ABC transporter signature motif; other site 290339004604 Walker B; other site 290339004605 D-loop; other site 290339004606 H-loop/switch region; other site 290339004607 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290339004608 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 290339004609 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290339004610 Walker A/P-loop; other site 290339004611 ATP binding site [chemical binding]; other site 290339004612 Q-loop/lid; other site 290339004613 ABC transporter signature motif; other site 290339004614 Walker B; other site 290339004615 D-loop; other site 290339004616 H-loop/switch region; other site 290339004617 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290339004618 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 290339004619 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 290339004620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339004621 dimer interface [polypeptide binding]; other site 290339004622 conserved gate region; other site 290339004623 putative PBP binding loops; other site 290339004624 ABC-ATPase subunit interface; other site 290339004625 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 290339004626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339004627 dimer interface [polypeptide binding]; other site 290339004628 conserved gate region; other site 290339004629 putative PBP binding loops; other site 290339004630 ABC-ATPase subunit interface; other site 290339004631 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 290339004632 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 290339004633 peptide binding site [polypeptide binding]; other site 290339004634 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 290339004635 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290339004636 Walker A motif; other site 290339004637 ATP binding site [chemical binding]; other site 290339004638 Walker B motif; other site 290339004639 arginine finger; other site 290339004640 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 290339004641 phage shock protein PspA; Provisional; Region: PRK10698 290339004642 phage shock protein B; Provisional; Region: pspB; PRK09458 290339004643 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 290339004644 phage shock protein C; Region: phageshock_pspC; TIGR02978 290339004645 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 290339004646 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 290339004647 sucrose phosphorylase; Provisional; Region: PRK13840 290339004648 active site 290339004649 homodimer interface [polypeptide binding]; other site 290339004650 catalytic site [active] 290339004651 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 290339004652 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290339004653 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290339004654 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 290339004655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339004656 dimer interface [polypeptide binding]; other site 290339004657 conserved gate region; other site 290339004658 putative PBP binding loops; other site 290339004659 ABC-ATPase subunit interface; other site 290339004660 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290339004661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339004662 dimer interface [polypeptide binding]; other site 290339004663 conserved gate region; other site 290339004664 putative PBP binding loops; other site 290339004665 ABC-ATPase subunit interface; other site 290339004666 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 290339004667 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 290339004668 putative NAD(P) binding site [chemical binding]; other site 290339004669 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 290339004670 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 290339004671 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 290339004672 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 290339004673 Int/Topo IB signature motif; other site 290339004674 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 290339004675 AAA domain; Region: AAA_24; pfam13479 290339004676 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 290339004677 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 290339004678 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290339004679 non-specific DNA binding site [nucleotide binding]; other site 290339004680 salt bridge; other site 290339004681 sequence-specific DNA binding site [nucleotide binding]; other site 290339004682 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 290339004683 Catalytic site [active] 290339004684 Bacteriophage CII protein; Region: Phage_CII; pfam05269 290339004685 Helix-turn-helix domain; Region: HTH_36; pfam13730 290339004686 Replication protein P; Region: Phage_lambda_P; pfam06992 290339004687 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290339004688 AAA domain; Region: AAA_21; pfam13304 290339004689 Walker A/P-loop; other site 290339004690 ATP binding site [chemical binding]; other site 290339004691 hypothetical protein; Provisional; Region: PRK09741 290339004692 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 290339004693 Endodeoxyribonuclease RusA; Region: RusA; cl01885 290339004694 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 290339004695 Lysis protein S; Region: Lysis_S; pfam04971 290339004696 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 290339004697 catalytic residues [active] 290339004698 anti-RssB factor; Provisional; Region: PRK10244 290339004699 Phage terminase, small subunit; Region: Terminase_4; pfam05119 290339004700 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 290339004701 Phage portal protein; Region: Phage_portal; pfam04860 290339004702 Phage-related protein [Function unknown]; Region: COG4695 290339004703 Phage head maturation protease [General function prediction only]; Region: COG3740 290339004704 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 290339004705 Phage capsid family; Region: Phage_capsid; pfam05065 290339004706 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 290339004707 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 290339004708 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 290339004709 oligomerization interface [polypeptide binding]; other site 290339004710 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 290339004711 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 290339004712 Septum formation initiator; Region: DivIC; cl17659 290339004713 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290339004714 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290339004715 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290339004716 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 290339004717 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 290339004718 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 290339004719 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 290339004720 beta-phosphoglucomutase; Region: bPGM; TIGR01990 290339004721 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290339004722 motif II; other site 290339004723 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 290339004724 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 290339004725 Walker A/P-loop; other site 290339004726 ATP binding site [chemical binding]; other site 290339004727 Q-loop/lid; other site 290339004728 ABC transporter signature motif; other site 290339004729 Walker B; other site 290339004730 D-loop; other site 290339004731 H-loop/switch region; other site 290339004732 TOBE domain; Region: TOBE_2; pfam08402 290339004733 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290339004734 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290339004735 DNA binding site [nucleotide binding] 290339004736 domain linker motif; other site 290339004737 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 290339004738 Predicted ATPase [General function prediction only]; Region: COG3106 290339004739 hypothetical protein; Provisional; Region: PRK05415 290339004740 Domain of unknown function (DUF697); Region: DUF697; cl12064 290339004741 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 290339004742 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 290339004743 putative aromatic amino acid binding site; other site 290339004744 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290339004745 putative active site [active] 290339004746 heme pocket [chemical binding]; other site 290339004747 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290339004748 Walker A motif; other site 290339004749 ATP binding site [chemical binding]; other site 290339004750 Walker B motif; other site 290339004751 arginine finger; other site 290339004752 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 290339004753 dimer interface [polypeptide binding]; other site 290339004754 catalytic triad [active] 290339004755 peroxidatic and resolving cysteines [active] 290339004756 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 290339004757 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 290339004758 active site 290339004759 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 290339004760 putative active site [active] 290339004761 Zn binding site [ion binding]; other site 290339004762 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 290339004763 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 290339004764 peptide binding site [polypeptide binding]; other site 290339004765 anti-adapter protein IraM; Provisional; Region: PRK09919 290339004766 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 290339004767 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 290339004768 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290339004769 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 290339004770 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 290339004771 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 290339004772 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 290339004773 Cl binding site [ion binding]; other site 290339004774 oligomer interface [polypeptide binding]; other site 290339004775 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 290339004776 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 290339004777 Ligand Binding Site [chemical binding]; other site 290339004778 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 290339004779 putative catalytic site [active] 290339004780 putative metal binding site [ion binding]; other site 290339004781 putative phosphate binding site [ion binding]; other site 290339004782 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 290339004783 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 290339004784 NAD binding site [chemical binding]; other site 290339004785 metal binding site [ion binding]; metal-binding site 290339004786 active site 290339004787 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 290339004788 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 290339004789 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 290339004790 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290339004791 Walker A motif; other site 290339004792 ATP binding site [chemical binding]; other site 290339004793 Walker B motif; other site 290339004794 arginine finger; other site 290339004795 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 290339004796 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 290339004797 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290339004798 NAD(P) binding site [chemical binding]; other site 290339004799 catalytic residues [active] 290339004800 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 290339004801 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 290339004802 NAD binding site [chemical binding]; other site 290339004803 substrate binding site [chemical binding]; other site 290339004804 catalytic Zn binding site [ion binding]; other site 290339004805 tetramer interface [polypeptide binding]; other site 290339004806 structural Zn binding site [ion binding]; other site 290339004807 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 290339004808 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 290339004809 dimer interface [polypeptide binding]; other site 290339004810 PYR/PP interface [polypeptide binding]; other site 290339004811 TPP binding site [chemical binding]; other site 290339004812 substrate binding site [chemical binding]; other site 290339004813 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 290339004814 Domain of unknown function; Region: EKR; smart00890 290339004815 4Fe-4S binding domain; Region: Fer4_6; pfam12837 290339004816 4Fe-4S binding domain; Region: Fer4; pfam00037 290339004817 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 290339004818 TPP-binding site [chemical binding]; other site 290339004819 dimer interface [polypeptide binding]; other site 290339004820 Domain of unknown function (DUF333); Region: DUF333; pfam03891 290339004821 META domain; Region: META; cl01245 290339004822 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 290339004823 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 290339004824 putative ligand binding site [chemical binding]; other site 290339004825 putative NAD binding site [chemical binding]; other site 290339004826 catalytic site [active] 290339004827 hypothetical protein; Provisional; Region: PRK10695 290339004828 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 290339004829 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 290339004830 azoreductase; Reviewed; Region: PRK00170 290339004831 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 290339004832 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 290339004833 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290339004834 ATP binding site [chemical binding]; other site 290339004835 putative Mg++ binding site [ion binding]; other site 290339004836 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290339004837 nucleotide binding region [chemical binding]; other site 290339004838 ATP-binding site [chemical binding]; other site 290339004839 Helicase associated domain (HA2); Region: HA2; pfam04408 290339004840 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 290339004841 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 290339004842 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 290339004843 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 290339004844 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 290339004845 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 290339004846 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 290339004847 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 290339004848 HlyD family secretion protein; Region: HlyD_3; pfam13437 290339004849 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339004850 putative substrate translocation pore; other site 290339004851 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 290339004852 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 290339004853 MarR family; Region: MarR_2; pfam12802 290339004854 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290339004855 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 290339004856 Coenzyme A binding pocket [chemical binding]; other site 290339004857 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 290339004858 FosA, a Fosfomycin resistance protein, catalyzes the addition of glutathione to the antibiotic fosfomycin, making it inactive; Region: FosA; cd07244 290339004859 dimer interface [polypeptide binding]; other site 290339004860 Mn binding site [ion binding]; other site 290339004861 K binding site [ion binding]; other site 290339004862 Uncharacterized conserved protein [Function unknown]; Region: COG1434 290339004863 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 290339004864 putative active site [active] 290339004865 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 290339004866 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290339004867 NAD binding site [chemical binding]; other site 290339004868 catalytic residues [active] 290339004869 substrate binding site [chemical binding]; other site 290339004870 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 290339004871 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 290339004872 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 290339004873 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339004874 metabolite-proton symporter; Region: 2A0106; TIGR00883 290339004875 putative substrate translocation pore; other site 290339004876 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 290339004877 putative metal binding site [ion binding]; other site 290339004878 putative homodimer interface [polypeptide binding]; other site 290339004879 putative homotetramer interface [polypeptide binding]; other site 290339004880 putative homodimer-homodimer interface [polypeptide binding]; other site 290339004881 putative allosteric switch controlling residues; other site 290339004882 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 290339004883 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 290339004884 substrate binding site [chemical binding]; other site 290339004885 catalytic Zn binding site [ion binding]; other site 290339004886 NAD binding site [chemical binding]; other site 290339004887 structural Zn binding site [ion binding]; other site 290339004888 dimer interface [polypeptide binding]; other site 290339004889 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 290339004890 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 290339004891 dimer interface [polypeptide binding]; other site 290339004892 ligand binding site [chemical binding]; other site 290339004893 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290339004894 dimerization interface [polypeptide binding]; other site 290339004895 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 290339004896 dimer interface [polypeptide binding]; other site 290339004897 putative CheW interface [polypeptide binding]; other site 290339004898 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 290339004899 dimerization interface [polypeptide binding]; other site 290339004900 metal binding site [ion binding]; metal-binding site 290339004901 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 290339004902 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 290339004903 FMN binding site [chemical binding]; other site 290339004904 active site 290339004905 substrate binding site [chemical binding]; other site 290339004906 catalytic residue [active] 290339004907 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 290339004908 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339004909 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290339004910 dimerization interface [polypeptide binding]; other site 290339004911 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 290339004912 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 290339004913 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 290339004914 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 290339004915 substrate binding pocket [chemical binding]; other site 290339004916 catalytic triad [active] 290339004917 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 290339004918 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 290339004919 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 290339004920 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290339004921 Coenzyme A binding pocket [chemical binding]; other site 290339004922 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 290339004923 putative trimer interface [polypeptide binding]; other site 290339004924 putative CoA binding site [chemical binding]; other site 290339004925 tellurite resistance protein TehB; Provisional; Region: PRK11207 290339004926 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290339004927 S-adenosylmethionine binding site [chemical binding]; other site 290339004928 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 290339004929 benzoate transporter; Region: benE; TIGR00843 290339004930 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 290339004931 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 290339004932 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290339004933 non-specific DNA binding site [nucleotide binding]; other site 290339004934 salt bridge; other site 290339004935 sequence-specific DNA binding site [nucleotide binding]; other site 290339004936 Cupin domain; Region: Cupin_2; pfam07883 290339004937 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 290339004938 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 290339004939 Peptidase family U32; Region: Peptidase_U32; pfam01136 290339004940 Collagenase; Region: DUF3656; pfam12392 290339004941 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 290339004942 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 290339004943 Catalytic site [active] 290339004944 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 290339004945 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 290339004946 active site 290339004947 DNA binding site [nucleotide binding] 290339004948 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 290339004949 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 290339004950 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 290339004951 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 290339004952 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 290339004953 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 290339004954 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 290339004955 active site 290339004956 Zn binding site [ion binding]; other site 290339004957 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 290339004958 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339004959 putative substrate translocation pore; other site 290339004960 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 290339004961 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339004962 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 290339004963 dimerization interface [polypeptide binding]; other site 290339004964 substrate binding pocket [chemical binding]; other site 290339004965 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 290339004966 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 290339004967 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 290339004968 putative dithiobiotin synthetase; Provisional; Region: PRK12374 290339004969 AAA domain; Region: AAA_26; pfam13500 290339004970 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 290339004971 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 290339004972 Walker A/P-loop; other site 290339004973 ATP binding site [chemical binding]; other site 290339004974 Q-loop/lid; other site 290339004975 ABC transporter signature motif; other site 290339004976 Walker B; other site 290339004977 D-loop; other site 290339004978 H-loop/switch region; other site 290339004979 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 290339004980 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339004981 dimer interface [polypeptide binding]; other site 290339004982 conserved gate region; other site 290339004983 ABC-ATPase subunit interface; other site 290339004984 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 290339004985 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 290339004986 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339004987 putative PBP binding loops; other site 290339004988 dimer interface [polypeptide binding]; other site 290339004989 ABC-ATPase subunit interface; other site 290339004990 GlpM protein; Region: GlpM; pfam06942 290339004991 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 290339004992 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 290339004993 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 290339004994 4Fe-4S binding domain; Region: Fer4; pfam00037 290339004995 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 290339004996 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 290339004997 putative [Fe4-S4] binding site [ion binding]; other site 290339004998 putative molybdopterin cofactor binding site [chemical binding]; other site 290339004999 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 290339005000 putative molybdopterin cofactor binding site; other site 290339005001 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 290339005002 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 290339005003 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 290339005004 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290339005005 Coenzyme A binding pocket [chemical binding]; other site 290339005006 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 290339005007 hypothetical protein; Provisional; Region: PRK13659 290339005008 hypothetical protein; Provisional; Region: PRK02237 290339005009 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 290339005010 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 290339005011 putative active site pocket [active] 290339005012 putative metal binding site [ion binding]; other site 290339005013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339005014 D-galactonate transporter; Region: 2A0114; TIGR00893 290339005015 putative substrate translocation pore; other site 290339005016 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 290339005017 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 290339005018 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 290339005019 YdfZ protein; Region: YdfZ; pfam14001 290339005020 Transcriptional regulators [Transcription]; Region: GntR; COG1802 290339005021 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290339005022 DNA-binding site [nucleotide binding]; DNA binding site 290339005023 FCD domain; Region: FCD; pfam07729 290339005024 malonic semialdehyde reductase; Provisional; Region: PRK10538 290339005025 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 290339005026 putative NAD(P) binding site [chemical binding]; other site 290339005027 homodimer interface [polypeptide binding]; other site 290339005028 homotetramer interface [polypeptide binding]; other site 290339005029 active site 290339005030 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 290339005031 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 290339005032 active site 290339005033 Zn binding site [ion binding]; other site 290339005034 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 290339005035 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 290339005036 DNA binding residues [nucleotide binding] 290339005037 dimer interface [polypeptide binding]; other site 290339005038 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 290339005039 Protein of unknown function (DUF1264); Region: DUF1264; pfam06884 290339005040 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 290339005041 substrate binding site [chemical binding]; other site 290339005042 THF binding site; other site 290339005043 zinc-binding site [ion binding]; other site 290339005044 allophanate hydrolase; Provisional; Region: PRK08186 290339005045 Amidase; Region: Amidase; pfam01425 290339005046 urea carboxylase; Region: urea_carbox; TIGR02712 290339005047 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 290339005048 ATP-grasp domain; Region: ATP-grasp_4; cl17255 290339005049 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 290339005050 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 290339005051 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 290339005052 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 290339005053 carboxyltransferase (CT) interaction site; other site 290339005054 biotinylation site [posttranslational modification]; other site 290339005055 Transcriptional regulators [Transcription]; Region: GntR; COG1802 290339005056 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290339005057 DNA-binding site [nucleotide binding]; DNA binding site 290339005058 FCD domain; Region: FCD; pfam07729 290339005059 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 290339005060 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 290339005061 putative ligand binding site [chemical binding]; other site 290339005062 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 290339005063 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290339005064 TM-ABC transporter signature motif; other site 290339005065 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 290339005066 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 290339005067 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 290339005068 TM-ABC transporter signature motif; other site 290339005069 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 290339005070 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 290339005071 Walker A/P-loop; other site 290339005072 ATP binding site [chemical binding]; other site 290339005073 Q-loop/lid; other site 290339005074 ABC transporter signature motif; other site 290339005075 Walker B; other site 290339005076 D-loop; other site 290339005077 H-loop/switch region; other site 290339005078 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 290339005079 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 290339005080 Walker A/P-loop; other site 290339005081 ATP binding site [chemical binding]; other site 290339005082 Q-loop/lid; other site 290339005083 ABC transporter signature motif; other site 290339005084 Walker B; other site 290339005085 D-loop; other site 290339005086 H-loop/switch region; other site 290339005087 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 290339005088 HTH-like domain; Region: HTH_21; pfam13276 290339005089 Integrase core domain; Region: rve; pfam00665 290339005090 Integrase core domain; Region: rve_2; pfam13333 290339005091 Transposase; Region: HTH_Tnp_1; cl17663 290339005092 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 290339005093 substrate binding site [chemical binding]; other site 290339005094 activation loop (A-loop); other site 290339005095 Protein phosphatase 2C; Region: PP2C_2; pfam13672 290339005096 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 290339005097 metal ion-dependent adhesion site (MIDAS); other site 290339005098 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 290339005099 metal ion-dependent adhesion site (MIDAS); other site 290339005100 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 290339005101 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 290339005102 putative metal binding site [ion binding]; other site 290339005103 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 290339005104 metal ion-dependent adhesion site (MIDAS); other site 290339005105 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 290339005106 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 290339005107 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 290339005108 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 290339005109 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290339005110 active site 290339005111 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 290339005112 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 290339005113 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 290339005114 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 290339005115 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 290339005116 putative metal binding site [ion binding]; other site 290339005117 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 290339005118 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 290339005119 putative metal binding site [ion binding]; other site 290339005120 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 290339005121 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 290339005122 putative metal binding site [ion binding]; other site 290339005123 tellurite resistance protein terB; Region: terB; cd07176 290339005124 putative metal binding site [ion binding]; other site 290339005125 Integral membrane protein TerC family; Region: TerC; cl10468 290339005126 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 290339005127 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 290339005128 putative metal binding site [ion binding]; other site 290339005129 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 290339005130 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 290339005131 putative metal binding site [ion binding]; other site 290339005132 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 290339005133 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 290339005134 putative metal binding site [ion binding]; other site 290339005135 Bacterial stress protein; Region: TerD; pfam02342 290339005136 putative transporter; Provisional; Region: PRK10054 290339005137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339005138 putative substrate translocation pore; other site 290339005139 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 290339005140 EamA-like transporter family; Region: EamA; pfam00892 290339005141 MarB protein; Region: MarB; pfam13999 290339005142 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 290339005143 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290339005144 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290339005145 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 290339005146 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 290339005147 putative arabinose transporter; Provisional; Region: PRK03545 290339005148 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339005149 putative substrate translocation pore; other site 290339005150 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 290339005151 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 290339005152 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 290339005153 NAD binding site [chemical binding]; other site 290339005154 dimer interface [polypeptide binding]; other site 290339005155 tetramer (dimer of dimers) interface [polypeptide binding]; other site 290339005156 substrate binding site [chemical binding]; other site 290339005157 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 290339005158 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290339005159 Coenzyme A binding pocket [chemical binding]; other site 290339005160 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290339005161 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339005162 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 290339005163 putative dimerization interface [polypeptide binding]; other site 290339005164 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 290339005165 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 290339005166 NAD(P) binding site [chemical binding]; other site 290339005167 catalytic residues [active] 290339005168 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 290339005169 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 290339005170 dimer interface [polypeptide binding]; other site 290339005171 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290339005172 dimerization interface [polypeptide binding]; other site 290339005173 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 290339005174 dimer interface [polypeptide binding]; other site 290339005175 putative CheW interface [polypeptide binding]; other site 290339005176 glutaminase; Provisional; Region: PRK00971 290339005177 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 290339005178 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 290339005179 MASE1; Region: MASE1; cl17823 290339005180 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 290339005181 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290339005182 metal binding site [ion binding]; metal-binding site 290339005183 active site 290339005184 I-site; other site 290339005185 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 290339005186 MASE2 domain; Region: MASE2; pfam05230 290339005187 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290339005188 metal binding site [ion binding]; metal-binding site 290339005189 active site 290339005190 I-site; other site 290339005191 GAF domain; Region: GAF; pfam01590 290339005192 GAF domain; Region: GAF_2; pfam13185 290339005193 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 290339005194 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290339005195 metal binding site [ion binding]; metal-binding site 290339005196 active site 290339005197 I-site; other site 290339005198 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290339005199 Coenzyme A binding pocket [chemical binding]; other site 290339005200 altronate oxidoreductase; Provisional; Region: PRK03643 290339005201 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 290339005202 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 290339005203 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 290339005204 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 290339005205 active site 290339005206 catalytic triad [active] 290339005207 oxyanion hole [active] 290339005208 Autotransporter beta-domain; Region: Autotransporter; cl17461 290339005209 trehalase; Provisional; Region: treF; PRK13270 290339005210 Trehalase; Region: Trehalase; cl17346 290339005211 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 290339005212 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 290339005213 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 290339005214 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 290339005215 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290339005216 putative active site [active] 290339005217 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 290339005218 heme pocket [chemical binding]; other site 290339005219 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290339005220 dimer interface [polypeptide binding]; other site 290339005221 phosphorylation site [posttranslational modification] 290339005222 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290339005223 ATP binding site [chemical binding]; other site 290339005224 Mg2+ binding site [ion binding]; other site 290339005225 G-X-G motif; other site 290339005226 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 290339005227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290339005228 active site 290339005229 phosphorylation site [posttranslational modification] 290339005230 intermolecular recognition site; other site 290339005231 dimerization interface [polypeptide binding]; other site 290339005232 Response regulator receiver domain; Region: Response_reg; pfam00072 290339005233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290339005234 active site 290339005235 phosphorylation site [posttranslational modification] 290339005236 intermolecular recognition site; other site 290339005237 dimerization interface [polypeptide binding]; other site 290339005238 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 290339005239 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 290339005240 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 290339005241 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 290339005242 DXD motif; other site 290339005243 OpgC protein; Region: OpgC_C; cl17858 290339005244 Response regulator receiver domain; Region: Response_reg; pfam00072 290339005245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290339005246 active site 290339005247 phosphorylation site [posttranslational modification] 290339005248 intermolecular recognition site; other site 290339005249 dimerization interface [polypeptide binding]; other site 290339005250 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 290339005251 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 290339005252 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 290339005253 anti sigma factor interaction site; other site 290339005254 regulatory phosphorylation site [posttranslational modification]; other site 290339005255 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 290339005256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 290339005257 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 290339005258 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290339005259 non-specific DNA binding site [nucleotide binding]; other site 290339005260 salt bridge; other site 290339005261 sequence-specific DNA binding site [nucleotide binding]; other site 290339005262 Cupin domain; Region: Cupin_2; pfam07883 290339005263 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 290339005264 B3/4 domain; Region: B3_4; pfam03483 290339005265 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 290339005266 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 290339005267 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290339005268 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 290339005269 dimerization interface [polypeptide binding]; other site 290339005270 putative effector binding pocket; other site 290339005271 Serine hydrolase; Region: Ser_hydrolase; cl17834 290339005272 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290339005273 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 290339005274 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 290339005275 DNA binding residues [nucleotide binding] 290339005276 putative dimer interface [polypeptide binding]; other site 290339005277 NlpC/P60 family; Region: NLPC_P60; pfam00877 290339005278 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 290339005279 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 290339005280 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 290339005281 EAL domain; Region: EAL; pfam00563 290339005282 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 290339005283 UV-endonuclease UvdE; Region: UvdE; cl10036 290339005284 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 290339005285 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 290339005286 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290339005287 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 290339005288 classical (c) SDRs; Region: SDR_c; cd05233 290339005289 NAD(P) binding site [chemical binding]; other site 290339005290 active site 290339005291 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 290339005292 TfoX N-terminal domain; Region: TfoX_N; pfam04993 290339005293 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 290339005294 classical (c) SDRs; Region: SDR_c; cd05233 290339005295 NAD(P) binding site [chemical binding]; other site 290339005296 active site 290339005297 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 290339005298 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 290339005299 putative NAD(P) binding site [chemical binding]; other site 290339005300 putative substrate binding site [chemical binding]; other site 290339005301 catalytic Zn binding site [ion binding]; other site 290339005302 structural Zn binding site [ion binding]; other site 290339005303 dimer interface [polypeptide binding]; other site 290339005304 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 290339005305 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 290339005306 Cupin; Region: Cupin_6; pfam12852 290339005307 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290339005308 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 290339005309 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290339005310 N-acetyltransferase; Region: Acetyltransf_2; cl00949 290339005311 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 290339005312 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 290339005313 dimanganese center [ion binding]; other site 290339005314 4-oxalocrotonate tautomerase; Provisional; Region: PRK01271 290339005315 active site 1 [active] 290339005316 dimer interface [polypeptide binding]; other site 290339005317 hexamer interface [polypeptide binding]; other site 290339005318 active site 2 [active] 290339005319 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 290339005320 dimer interface [polypeptide binding]; other site 290339005321 FMN binding site [chemical binding]; other site 290339005322 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 290339005323 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 290339005324 L-asparagine permease; Provisional; Region: PRK15049 290339005325 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 290339005326 NMT1-like family; Region: NMT1_2; pfam13379 290339005327 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 290339005328 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 290339005329 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 290339005330 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 290339005331 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 290339005332 Walker A/P-loop; other site 290339005333 ATP binding site [chemical binding]; other site 290339005334 Q-loop/lid; other site 290339005335 ABC transporter signature motif; other site 290339005336 Walker B; other site 290339005337 D-loop; other site 290339005338 H-loop/switch region; other site 290339005339 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 290339005340 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339005341 dimer interface [polypeptide binding]; other site 290339005342 ABC-ATPase subunit interface; other site 290339005343 putative PBP binding loops; other site 290339005344 PQQ-like domain; Region: PQQ_2; pfam13360 290339005345 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 290339005346 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 290339005347 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 290339005348 N-terminal plug; other site 290339005349 ligand-binding site [chemical binding]; other site 290339005350 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 290339005351 sequence-specific DNA binding site [nucleotide binding]; other site 290339005352 salt bridge; other site 290339005353 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 290339005354 trehalose synthase; Region: treS_nterm; TIGR02456 290339005355 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 290339005356 active site 290339005357 catalytic site [active] 290339005358 short chain dehydrogenase; Provisional; Region: PRK07109 290339005359 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 290339005360 putative NAD(P) binding site [chemical binding]; other site 290339005361 active site 290339005362 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 290339005363 HAMP domain; Region: HAMP; pfam00672 290339005364 dimerization interface [polypeptide binding]; other site 290339005365 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 290339005366 dimer interface [polypeptide binding]; other site 290339005367 putative CheW interface [polypeptide binding]; other site 290339005368 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 290339005369 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290339005370 DNA-binding site [nucleotide binding]; DNA binding site 290339005371 FCD domain; Region: FCD; pfam07729 290339005372 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 290339005373 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 290339005374 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 290339005375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339005376 dimer interface [polypeptide binding]; other site 290339005377 conserved gate region; other site 290339005378 putative PBP binding loops; other site 290339005379 ABC-ATPase subunit interface; other site 290339005380 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 290339005381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339005382 dimer interface [polypeptide binding]; other site 290339005383 conserved gate region; other site 290339005384 putative PBP binding loops; other site 290339005385 ABC-ATPase subunit interface; other site 290339005386 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 290339005387 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 290339005388 metal binding site [ion binding]; metal-binding site 290339005389 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 290339005390 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 290339005391 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 290339005392 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290339005393 Q-loop/lid; other site 290339005394 ABC transporter signature motif; other site 290339005395 Walker B; other site 290339005396 D-loop; other site 290339005397 H-loop/switch region; other site 290339005398 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 290339005399 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290339005400 Walker A/P-loop; other site 290339005401 ATP binding site [chemical binding]; other site 290339005402 Q-loop/lid; other site 290339005403 ABC transporter signature motif; other site 290339005404 Walker B; other site 290339005405 D-loop; other site 290339005406 H-loop/switch region; other site 290339005407 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290339005408 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 290339005409 Prostaglandin dehydrogenases; Region: PGDH; cd05288 290339005410 NAD(P) binding site [chemical binding]; other site 290339005411 substrate binding site [chemical binding]; other site 290339005412 dimer interface [polypeptide binding]; other site 290339005413 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290339005414 non-specific DNA binding site [nucleotide binding]; other site 290339005415 salt bridge; other site 290339005416 sequence-specific DNA binding site [nucleotide binding]; other site 290339005417 Cupin domain; Region: Cupin_2; pfam07883 290339005418 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 290339005419 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290339005420 Coenzyme A binding pocket [chemical binding]; other site 290339005421 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 290339005422 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 290339005423 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 290339005424 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 290339005425 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 290339005426 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 290339005427 peptide binding site [polypeptide binding]; other site 290339005428 Virulence factor SrfB; Region: SrfB; pfam07520 290339005429 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458 290339005430 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 290339005431 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 290339005432 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 290339005433 Metal-binding active site; metal-binding site 290339005434 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 290339005435 Tar ligand binding domain homologue; Region: TarH; pfam02203 290339005436 dimer interface [polypeptide binding]; other site 290339005437 ligand binding site [chemical binding]; other site 290339005438 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 290339005439 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290339005440 dimerization interface [polypeptide binding]; other site 290339005441 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 290339005442 dimer interface [polypeptide binding]; other site 290339005443 putative CheW interface [polypeptide binding]; other site 290339005444 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 290339005445 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 290339005446 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 290339005447 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 290339005448 4Fe-4S binding domain; Region: Fer4; pfam00037 290339005449 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 290339005450 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 290339005451 putative [Fe4-S4] binding site [ion binding]; other site 290339005452 putative molybdopterin cofactor binding site [chemical binding]; other site 290339005453 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 290339005454 putative molybdopterin cofactor binding site; other site 290339005455 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 290339005456 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 290339005457 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 290339005458 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 290339005459 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 290339005460 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 290339005461 Coenzyme A binding pocket [chemical binding]; other site 290339005462 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290339005463 Coenzyme A binding pocket [chemical binding]; other site 290339005464 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 290339005465 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 290339005466 tetrameric interface [polypeptide binding]; other site 290339005467 NAD binding site [chemical binding]; other site 290339005468 catalytic residues [active] 290339005469 substrate binding site [chemical binding]; other site 290339005470 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 290339005471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339005472 putative PBP binding loops; other site 290339005473 dimer interface [polypeptide binding]; other site 290339005474 ABC-ATPase subunit interface; other site 290339005475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339005476 dimer interface [polypeptide binding]; other site 290339005477 conserved gate region; other site 290339005478 putative PBP binding loops; other site 290339005479 ABC-ATPase subunit interface; other site 290339005480 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 290339005481 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290339005482 Walker A/P-loop; other site 290339005483 ATP binding site [chemical binding]; other site 290339005484 Q-loop/lid; other site 290339005485 ABC transporter signature motif; other site 290339005486 Walker B; other site 290339005487 D-loop; other site 290339005488 H-loop/switch region; other site 290339005489 TOBE domain; Region: TOBE_2; pfam08402 290339005490 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 290339005491 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 290339005492 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 290339005493 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290339005494 DNA-binding site [nucleotide binding]; DNA binding site 290339005495 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290339005496 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339005497 homodimer interface [polypeptide binding]; other site 290339005498 catalytic residue [active] 290339005499 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 290339005500 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 290339005501 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 290339005502 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 290339005503 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 290339005504 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290339005505 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290339005506 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 290339005507 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 290339005508 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 290339005509 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 290339005510 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 290339005511 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 290339005512 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 290339005513 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 290339005514 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339005515 dimer interface [polypeptide binding]; other site 290339005516 conserved gate region; other site 290339005517 ABC-ATPase subunit interface; other site 290339005518 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 290339005519 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339005520 putative PBP binding loops; other site 290339005521 dimer interface [polypeptide binding]; other site 290339005522 ABC-ATPase subunit interface; other site 290339005523 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 290339005524 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290339005525 Walker A/P-loop; other site 290339005526 ATP binding site [chemical binding]; other site 290339005527 Q-loop/lid; other site 290339005528 ABC transporter signature motif; other site 290339005529 Walker B; other site 290339005530 D-loop; other site 290339005531 H-loop/switch region; other site 290339005532 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290339005533 Walker A/P-loop; other site 290339005534 ATP binding site [chemical binding]; other site 290339005535 Q-loop/lid; other site 290339005536 ABC transporter signature motif; other site 290339005537 Walker B; other site 290339005538 D-loop; other site 290339005539 H-loop/switch region; other site 290339005540 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290339005541 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 290339005542 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 290339005543 CMD domain protein, Avi_7170 family; Region: CMD_Avi_7170; TIGR04029 290339005544 alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030 290339005545 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 290339005546 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 290339005547 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290339005548 active site 290339005549 motif I; other site 290339005550 motif II; other site 290339005551 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290339005552 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 290339005553 Smr domain; Region: Smr; pfam01713 290339005554 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 290339005555 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 290339005556 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 290339005557 DNA binding site [nucleotide binding] 290339005558 active site 290339005559 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 290339005560 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 290339005561 ligand binding site [chemical binding]; other site 290339005562 flexible hinge region; other site 290339005563 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 290339005564 putative switch regulator; other site 290339005565 non-specific DNA interactions [nucleotide binding]; other site 290339005566 DNA binding site [nucleotide binding] 290339005567 sequence specific DNA binding site [nucleotide binding]; other site 290339005568 putative cAMP binding site [chemical binding]; other site 290339005569 universal stress protein UspE; Provisional; Region: PRK11175 290339005570 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290339005571 Ligand Binding Site [chemical binding]; other site 290339005572 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290339005573 Ligand Binding Site [chemical binding]; other site 290339005574 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 290339005575 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 290339005576 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 290339005577 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 290339005578 ligand binding site [chemical binding]; other site 290339005579 homodimer interface [polypeptide binding]; other site 290339005580 NAD(P) binding site [chemical binding]; other site 290339005581 trimer interface B [polypeptide binding]; other site 290339005582 trimer interface A [polypeptide binding]; other site 290339005583 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 290339005584 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 290339005585 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 290339005586 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 290339005587 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 290339005588 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 290339005589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290339005590 active site 290339005591 phosphorylation site [posttranslational modification] 290339005592 intermolecular recognition site; other site 290339005593 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290339005594 DNA binding site [nucleotide binding] 290339005595 short chain dehydrogenase; Provisional; Region: PRK06500 290339005596 classical (c) SDRs; Region: SDR_c; cd05233 290339005597 NAD(P) binding site [chemical binding]; other site 290339005598 active site 290339005599 LysR family transcriptional regulator; Provisional; Region: PRK14997 290339005600 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339005601 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 290339005602 putative effector binding pocket; other site 290339005603 putative dimerization interface [polypeptide binding]; other site 290339005604 sensor protein RstB; Provisional; Region: PRK10604 290339005605 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290339005606 dimerization interface [polypeptide binding]; other site 290339005607 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290339005608 dimer interface [polypeptide binding]; other site 290339005609 phosphorylation site [posttranslational modification] 290339005610 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290339005611 ATP binding site [chemical binding]; other site 290339005612 Mg2+ binding site [ion binding]; other site 290339005613 G-X-G motif; other site 290339005614 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 290339005615 fumarate hydratase; Reviewed; Region: fumC; PRK00485 290339005616 Class II fumarases; Region: Fumarase_classII; cd01362 290339005617 active site 290339005618 tetramer interface [polypeptide binding]; other site 290339005619 fumarate hydratase; Provisional; Region: PRK15389 290339005620 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 290339005621 Fumarase C-terminus; Region: Fumerase_C; pfam05683 290339005622 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 290339005623 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 290339005624 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 290339005625 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 290339005626 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 290339005627 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 290339005628 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 290339005629 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 290339005630 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 290339005631 PapC N-terminal domain; Region: PapC_N; pfam13954 290339005632 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 290339005633 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 290339005634 PapC C-terminal domain; Region: PapC_C; pfam13953 290339005635 fimbrial assembly chaperone SthB; Provisional; Region: PRK15295 290339005636 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 290339005637 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 290339005638 Fimbrial protein; Region: Fimbrial; cl01416 290339005639 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 290339005640 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290339005641 DNA binding site [nucleotide binding] 290339005642 domain linker motif; other site 290339005643 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 290339005644 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 290339005645 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 290339005646 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 290339005647 active site turn [active] 290339005648 phosphorylation site [posttranslational modification] 290339005649 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 290339005650 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290339005651 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339005652 homodimer interface [polypeptide binding]; other site 290339005653 catalytic residue [active] 290339005654 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 290339005655 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 290339005656 active site 290339005657 purine riboside binding site [chemical binding]; other site 290339005658 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 290339005659 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 290339005660 putative oxidoreductase; Provisional; Region: PRK11579 290339005661 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290339005662 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290339005663 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 290339005664 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 290339005665 electron transport complex protein RsxA; Provisional; Region: PRK05151 290339005666 ferredoxin; Provisional; Region: PRK08764 290339005667 Putative Fe-S cluster; Region: FeS; pfam04060 290339005668 4Fe-4S binding domain; Region: Fer4; cl02805 290339005669 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 290339005670 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 290339005671 lipoyl-biotinyl attachment site [posttranslational modification]; other site 290339005672 SLBB domain; Region: SLBB; pfam10531 290339005673 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 290339005674 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 290339005675 electron transport complex protein RnfG; Validated; Region: PRK01908 290339005676 electron transport complex RsxE subunit; Provisional; Region: PRK12405 290339005677 endonuclease III; Provisional; Region: PRK10702 290339005678 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 290339005679 minor groove reading motif; other site 290339005680 helix-hairpin-helix signature motif; other site 290339005681 substrate binding pocket [chemical binding]; other site 290339005682 active site 290339005683 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 290339005684 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 290339005685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339005686 putative substrate translocation pore; other site 290339005687 POT family; Region: PTR2; pfam00854 290339005688 glutathionine S-transferase; Provisional; Region: PRK10542 290339005689 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 290339005690 C-terminal domain interface [polypeptide binding]; other site 290339005691 GSH binding site (G-site) [chemical binding]; other site 290339005692 dimer interface [polypeptide binding]; other site 290339005693 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 290339005694 dimer interface [polypeptide binding]; other site 290339005695 N-terminal domain interface [polypeptide binding]; other site 290339005696 substrate binding pocket (H-site) [chemical binding]; other site 290339005697 pyridoxamine kinase; Validated; Region: PRK05756 290339005698 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 290339005699 dimer interface [polypeptide binding]; other site 290339005700 pyridoxal binding site [chemical binding]; other site 290339005701 ATP binding site [chemical binding]; other site 290339005702 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 290339005703 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 290339005704 active site 290339005705 HIGH motif; other site 290339005706 dimer interface [polypeptide binding]; other site 290339005707 KMSKS motif; other site 290339005708 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 290339005709 RNA binding surface [nucleotide binding]; other site 290339005710 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 290339005711 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 290339005712 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 290339005713 lysozyme inhibitor; Provisional; Region: PRK11372 290339005714 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 290339005715 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 290339005716 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 290339005717 transcriptional regulator SlyA; Provisional; Region: PRK03573 290339005718 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 290339005719 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 290339005720 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 290339005721 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 290339005722 HlyD family secretion protein; Region: HlyD_3; pfam13437 290339005723 Fusaric acid resistance protein family; Region: FUSC; pfam04632 290339005724 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 290339005725 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 290339005726 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 290339005727 E-class dimer interface [polypeptide binding]; other site 290339005728 P-class dimer interface [polypeptide binding]; other site 290339005729 active site 290339005730 Cu2+ binding site [ion binding]; other site 290339005731 Zn2+ binding site [ion binding]; other site 290339005732 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290339005733 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290339005734 active site 290339005735 catalytic tetrad [active] 290339005736 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 290339005737 putative metal dependent hydrolase; Provisional; Region: PRK11598 290339005738 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 290339005739 Sulfatase; Region: Sulfatase; pfam00884 290339005740 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290339005741 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290339005742 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 290339005743 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 290339005744 FMN binding site [chemical binding]; other site 290339005745 active site 290339005746 substrate binding site [chemical binding]; other site 290339005747 catalytic residue [active] 290339005748 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290339005749 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 290339005750 dimer interface [polypeptide binding]; other site 290339005751 active site 290339005752 metal binding site [ion binding]; metal-binding site 290339005753 glutathione binding site [chemical binding]; other site 290339005754 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 290339005755 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 290339005756 dimer interface [polypeptide binding]; other site 290339005757 catalytic site [active] 290339005758 putative active site [active] 290339005759 putative substrate binding site [chemical binding]; other site 290339005760 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 290339005761 putative GSH binding site [chemical binding]; other site 290339005762 catalytic residues [active] 290339005763 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 290339005764 NlpC/P60 family; Region: NLPC_P60; pfam00877 290339005765 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339005766 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290339005767 putative substrate translocation pore; other site 290339005768 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 290339005769 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290339005770 DNA binding site [nucleotide binding] 290339005771 domain linker motif; other site 290339005772 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 290339005773 dimerization interface [polypeptide binding]; other site 290339005774 ligand binding site [chemical binding]; other site 290339005775 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 290339005776 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339005777 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290339005778 dimerization interface [polypeptide binding]; other site 290339005779 putative transporter; Provisional; Region: PRK11043 290339005780 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339005781 putative substrate translocation pore; other site 290339005782 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 290339005783 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290339005784 S-adenosylmethionine binding site [chemical binding]; other site 290339005785 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 290339005786 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 290339005787 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 290339005788 beta-galactosidase; Region: BGL; TIGR03356 290339005789 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290339005790 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290339005791 DNA binding site [nucleotide binding] 290339005792 domain linker motif; other site 290339005793 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290339005794 dimerization interface [polypeptide binding]; other site 290339005795 ligand binding site [chemical binding]; other site 290339005796 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 290339005797 Lumazine binding domain; Region: Lum_binding; pfam00677 290339005798 Lumazine binding domain; Region: Lum_binding; pfam00677 290339005799 multidrug efflux protein; Reviewed; Region: PRK01766 290339005800 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 290339005801 cation binding site [ion binding]; other site 290339005802 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 290339005803 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 290339005804 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 290339005805 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 290339005806 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 290339005807 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 290339005808 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 290339005809 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 290339005810 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 290339005811 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 290339005812 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 290339005813 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 290339005814 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 290339005815 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 290339005816 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 290339005817 Protein of unknown function (DUF877); Region: DUF877; pfam05943 290339005818 Protein of unknown function (DUF770); Region: DUF770; pfam05591 290339005819 AAA domain; Region: AAA_28; pfam13521 290339005820 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290339005821 Walker A motif; other site 290339005822 ATP binding site [chemical binding]; other site 290339005823 Walker B motif; other site 290339005824 choline transport protein BetT; Provisional; Region: PRK09928 290339005825 transcriptional regulator BetI; Validated; Region: PRK00767 290339005826 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290339005827 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 290339005828 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 290339005829 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 290339005830 tetrameric interface [polypeptide binding]; other site 290339005831 NAD binding site [chemical binding]; other site 290339005832 catalytic residues [active] 290339005833 choline dehydrogenase; Validated; Region: PRK02106 290339005834 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 290339005835 Uncharacterized conserved protein [Function unknown]; Region: COG3791 290339005836 Sigma-S stabilisation anti-adaptor protein; Region: Anti-adapt_IraP; pfam10796 290339005837 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339005838 putative substrate translocation pore; other site 290339005839 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 290339005840 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339005841 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 290339005842 putative substrate binding pocket [chemical binding]; other site 290339005843 putative dimerization interface [polypeptide binding]; other site 290339005844 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 290339005845 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 290339005846 Acylphosphatase; Region: Acylphosphatase; pfam00708 290339005847 HypF finger; Region: zf-HYPF; pfam07503 290339005848 HypF finger; Region: zf-HYPF; pfam07503 290339005849 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 290339005850 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 290339005851 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 290339005852 [4Fe-4S] binding site [ion binding]; other site 290339005853 molybdopterin cofactor binding site; other site 290339005854 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 290339005855 molybdopterin cofactor binding site; other site 290339005856 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 290339005857 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 290339005858 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 290339005859 nickel binding site [ion binding]; other site 290339005860 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 290339005861 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 290339005862 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 290339005863 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 290339005864 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 290339005865 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 290339005866 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 290339005867 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 290339005868 NADH dehydrogenase; Region: NADHdh; cl00469 290339005869 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 290339005870 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 290339005871 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 290339005872 4Fe-4S binding domain; Region: Fer4; cl02805 290339005873 Transcriptional repressor of hyc and hyp operons; Region: HycA_repressor; pfam11046 290339005874 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 290339005875 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 290339005876 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 290339005877 hydrogenase assembly chaperone; Provisional; Region: PRK10409 290339005878 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 290339005879 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 290339005880 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 290339005881 dimerization interface [polypeptide binding]; other site 290339005882 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 290339005883 ATP binding site [chemical binding]; other site 290339005884 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 290339005885 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 290339005886 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 290339005887 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290339005888 Walker A motif; other site 290339005889 ATP binding site [chemical binding]; other site 290339005890 Walker B motif; other site 290339005891 arginine finger; other site 290339005892 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 290339005893 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 290339005894 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 290339005895 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 290339005896 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 290339005897 catalytic triad [active] 290339005898 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 290339005899 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290339005900 non-specific DNA binding site [nucleotide binding]; other site 290339005901 salt bridge; other site 290339005902 sequence-specific DNA binding site [nucleotide binding]; other site 290339005903 Cupin domain; Region: Cupin_2; pfam07883 290339005904 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 290339005905 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 290339005906 NAD(P) binding site [chemical binding]; other site 290339005907 catalytic residues [active] 290339005908 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 290339005909 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 290339005910 hypothetical protein; Provisional; Region: PRK09945 290339005911 hypothetical protein; Provisional; Region: PRK09945 290339005912 hypothetical protein; Provisional; Region: PRK09945 290339005913 hypothetical protein; Provisional; Region: PRK09945 290339005914 hypothetical protein; Provisional; Region: PRK09945 290339005915 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 290339005916 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 290339005917 Autotransporter beta-domain; Region: Autotransporter; smart00869 290339005918 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290339005919 pyruvate kinase; Provisional; Region: PRK09206 290339005920 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 290339005921 active site 290339005922 domain interfaces; other site 290339005923 murein lipoprotein; Provisional; Region: PRK15396 290339005924 L,D-transpeptidase; Provisional; Region: PRK10190 290339005925 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 290339005926 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 290339005927 cysteine desufuration protein SufE; Provisional; Region: PRK09296 290339005928 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 290339005929 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 290339005930 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290339005931 catalytic residue [active] 290339005932 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 290339005933 FeS assembly protein SufD; Region: sufD; TIGR01981 290339005934 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 290339005935 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 290339005936 Walker A/P-loop; other site 290339005937 ATP binding site [chemical binding]; other site 290339005938 Q-loop/lid; other site 290339005939 ABC transporter signature motif; other site 290339005940 Walker B; other site 290339005941 D-loop; other site 290339005942 H-loop/switch region; other site 290339005943 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 290339005944 putative ABC transporter; Region: ycf24; CHL00085 290339005945 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 290339005946 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 290339005947 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 290339005948 catalytic core [active] 290339005949 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 290339005950 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 290339005951 CoenzymeA binding site [chemical binding]; other site 290339005952 subunit interaction site [polypeptide binding]; other site 290339005953 PHB binding site; other site 290339005954 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 290339005955 FAD binding domain; Region: FAD_binding_4; pfam01565 290339005956 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 290339005957 putative inner membrane protein; Provisional; Region: PRK10983 290339005958 Domain of unknown function DUF20; Region: UPF0118; pfam01594 290339005959 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 290339005960 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 290339005961 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 290339005962 putative symporter YagG; Provisional; Region: PRK09669 290339005963 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 290339005964 phosphoenolpyruvate synthase; Validated; Region: PRK06464 290339005965 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 290339005966 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 290339005967 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 290339005968 PEP synthetase regulatory protein; Provisional; Region: PRK05339 290339005969 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 290339005970 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 290339005971 hypothetical protein; Validated; Region: PRK00029 290339005972 Uncharacterized conserved protein [Function unknown]; Region: COG0397 290339005973 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 290339005974 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290339005975 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290339005976 DNA binding site [nucleotide binding] 290339005977 domain linker motif; other site 290339005978 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 290339005979 dimerization interface (closed form) [polypeptide binding]; other site 290339005980 ligand binding site [chemical binding]; other site 290339005981 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 290339005982 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 290339005983 NAD binding site [chemical binding]; other site 290339005984 sugar binding site [chemical binding]; other site 290339005985 divalent metal binding site [ion binding]; other site 290339005986 tetramer (dimer of dimers) interface [polypeptide binding]; other site 290339005987 dimer interface [polypeptide binding]; other site 290339005988 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 290339005989 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 290339005990 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 290339005991 NlpC/P60 family; Region: NLPC_P60; pfam00877 290339005992 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 290339005993 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 290339005994 Walker A/P-loop; other site 290339005995 ATP binding site [chemical binding]; other site 290339005996 Q-loop/lid; other site 290339005997 ABC transporter signature motif; other site 290339005998 Walker B; other site 290339005999 D-loop; other site 290339006000 H-loop/switch region; other site 290339006001 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 290339006002 catalytic residues [active] 290339006003 dimer interface [polypeptide binding]; other site 290339006004 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 290339006005 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290339006006 dimer interface [polypeptide binding]; other site 290339006007 putative PBP binding regions; other site 290339006008 ABC-ATPase subunit interface; other site 290339006009 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 290339006010 IHF dimer interface [polypeptide binding]; other site 290339006011 IHF - DNA interface [nucleotide binding]; other site 290339006012 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 290339006013 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 290339006014 putative tRNA-binding site [nucleotide binding]; other site 290339006015 B3/4 domain; Region: B3_4; pfam03483 290339006016 tRNA synthetase B5 domain; Region: B5; smart00874 290339006017 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 290339006018 dimer interface [polypeptide binding]; other site 290339006019 motif 1; other site 290339006020 motif 3; other site 290339006021 motif 2; other site 290339006022 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 290339006023 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 290339006024 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 290339006025 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 290339006026 dimer interface [polypeptide binding]; other site 290339006027 motif 1; other site 290339006028 active site 290339006029 motif 2; other site 290339006030 motif 3; other site 290339006031 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 290339006032 23S rRNA binding site [nucleotide binding]; other site 290339006033 L21 binding site [polypeptide binding]; other site 290339006034 L13 binding site [polypeptide binding]; other site 290339006035 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 290339006036 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 290339006037 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 290339006038 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 290339006039 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 290339006040 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 290339006041 active site 290339006042 dimer interface [polypeptide binding]; other site 290339006043 motif 1; other site 290339006044 motif 2; other site 290339006045 motif 3; other site 290339006046 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 290339006047 anticodon binding site; other site 290339006048 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 290339006049 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290339006050 Coenzyme A binding pocket [chemical binding]; other site 290339006051 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290339006052 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339006053 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290339006054 dimerization interface [polypeptide binding]; other site 290339006055 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 290339006056 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 290339006057 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 290339006058 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290339006059 Coenzyme A binding pocket [chemical binding]; other site 290339006060 ecotin; Provisional; Region: PRK03719 290339006061 secondary substrate binding site; other site 290339006062 primary substrate binding site; other site 290339006063 inhibition loop; other site 290339006064 dimerization interface [polypeptide binding]; other site 290339006065 proline/glycine betaine transporter; Provisional; Region: PRK10642 290339006066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339006067 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339006068 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 290339006069 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 290339006070 6-phosphofructokinase 2; Provisional; Region: PRK10294 290339006071 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 290339006072 putative substrate binding site [chemical binding]; other site 290339006073 putative ATP binding site [chemical binding]; other site 290339006074 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 290339006075 Fructosamine kinase; Region: Fructosamin_kin; pfam03881 290339006076 Phosphotransferase enzyme family; Region: APH; pfam01636 290339006077 YniB-like protein; Region: YniB; pfam14002 290339006078 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 290339006079 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 290339006080 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290339006081 motif II; other site 290339006082 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 290339006083 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 290339006084 NADP binding site [chemical binding]; other site 290339006085 homodimer interface [polypeptide binding]; other site 290339006086 active site 290339006087 inner membrane protein; Provisional; Region: PRK11648 290339006088 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 290339006089 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 290339006090 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 290339006091 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290339006092 sequence-specific DNA binding site [nucleotide binding]; other site 290339006093 salt bridge; other site 290339006094 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 290339006095 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 290339006096 cell division modulator; Provisional; Region: PRK10113 290339006097 hydroperoxidase II; Provisional; Region: katE; PRK11249 290339006098 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 290339006099 tetramer interface [polypeptide binding]; other site 290339006100 heme binding pocket [chemical binding]; other site 290339006101 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 290339006102 domain interactions; other site 290339006103 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 290339006104 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 290339006105 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 290339006106 homodimer interface [polypeptide binding]; other site 290339006107 NAD binding pocket [chemical binding]; other site 290339006108 ATP binding pocket [chemical binding]; other site 290339006109 Mg binding site [ion binding]; other site 290339006110 active-site loop [active] 290339006111 aromatic amino acid exporter; Provisional; Region: PRK11689 290339006112 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 290339006113 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 290339006114 GIY-YIG motif/motif A; other site 290339006115 active site 290339006116 catalytic site [active] 290339006117 putative DNA binding site [nucleotide binding]; other site 290339006118 metal binding site [ion binding]; metal-binding site 290339006119 hypothetical protein; Provisional; Region: PRK11396 290339006120 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 290339006121 dimer interface [polypeptide binding]; other site 290339006122 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 290339006123 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 290339006124 putative active site [active] 290339006125 Zn binding site [ion binding]; other site 290339006126 succinylarginine dihydrolase; Provisional; Region: PRK13281 290339006127 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 290339006128 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 290339006129 NAD(P) binding site [chemical binding]; other site 290339006130 catalytic residues [active] 290339006131 arginine succinyltransferase; Provisional; Region: PRK10456 290339006132 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 290339006133 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 290339006134 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 290339006135 inhibitor-cofactor binding pocket; inhibition site 290339006136 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339006137 catalytic residue [active] 290339006138 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 290339006139 putative catalytic site [active] 290339006140 putative phosphate binding site [ion binding]; other site 290339006141 active site 290339006142 metal binding site A [ion binding]; metal-binding site 290339006143 DNA binding site [nucleotide binding] 290339006144 putative AP binding site [nucleotide binding]; other site 290339006145 putative metal binding site B [ion binding]; other site 290339006146 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 290339006147 active site 290339006148 8-oxo-dGMP binding site [chemical binding]; other site 290339006149 nudix motif; other site 290339006150 metal binding site [ion binding]; metal-binding site 290339006151 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 290339006152 DNA topoisomerase III; Provisional; Region: PRK07726 290339006153 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 290339006154 active site 290339006155 putative interdomain interaction site [polypeptide binding]; other site 290339006156 putative metal-binding site [ion binding]; other site 290339006157 putative nucleotide binding site [chemical binding]; other site 290339006158 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 290339006159 domain I; other site 290339006160 DNA binding groove [nucleotide binding] 290339006161 phosphate binding site [ion binding]; other site 290339006162 domain II; other site 290339006163 domain III; other site 290339006164 nucleotide binding site [chemical binding]; other site 290339006165 catalytic site [active] 290339006166 domain IV; other site 290339006167 selenophosphate synthetase; Provisional; Region: PRK00943 290339006168 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 290339006169 dimerization interface [polypeptide binding]; other site 290339006170 putative ATP binding site [chemical binding]; other site 290339006171 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 290339006172 putative FMN binding site [chemical binding]; other site 290339006173 protease 4; Provisional; Region: PRK10949 290339006174 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 290339006175 tandem repeat interface [polypeptide binding]; other site 290339006176 oligomer interface [polypeptide binding]; other site 290339006177 active site residues [active] 290339006178 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 290339006179 tandem repeat interface [polypeptide binding]; other site 290339006180 oligomer interface [polypeptide binding]; other site 290339006181 active site residues [active] 290339006182 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 290339006183 active site 290339006184 homodimer interface [polypeptide binding]; other site 290339006185 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 290339006186 Isochorismatase family; Region: Isochorismatase; pfam00857 290339006187 catalytic triad [active] 290339006188 metal binding site [ion binding]; metal-binding site 290339006189 conserved cis-peptide bond; other site 290339006190 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 290339006191 methionine sulfoxide reductase B; Provisional; Region: PRK00222 290339006192 SelR domain; Region: SelR; pfam01641 290339006193 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 290339006194 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 290339006195 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 290339006196 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 290339006197 active site 290339006198 phosphate binding residues; other site 290339006199 catalytic residues [active] 290339006200 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 290339006201 PrkA family serine protein kinase; Provisional; Region: PRK15455 290339006202 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290339006203 Walker A motif; other site 290339006204 ATP binding site [chemical binding]; other site 290339006205 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 290339006206 hypothetical protein; Provisional; Region: PRK05325 290339006207 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 290339006208 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 290339006209 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290339006210 General stress protein [General function prediction only]; Region: GsiB; COG3729 290339006211 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 290339006212 putative deacylase active site [active] 290339006213 Predicted membrane protein [Function unknown]; Region: COG2707 290339006214 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 290339006215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339006216 hypothetical protein; Validated; Region: PRK06186 290339006217 conserved cys residue [active] 290339006218 Uncharacterized conserved protein [Function unknown]; Region: COG3189 290339006219 Protein of unknown function (DUF535); Region: DUF535; pfam04393 290339006220 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 290339006221 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 290339006222 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 290339006223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290339006224 active site 290339006225 phosphorylation site [posttranslational modification] 290339006226 intermolecular recognition site; other site 290339006227 dimerization interface [polypeptide binding]; other site 290339006228 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 290339006229 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 290339006230 DNA-binding site [nucleotide binding]; DNA binding site 290339006231 RNA-binding motif; other site 290339006232 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 290339006233 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 290339006234 Tar ligand binding domain homologue; Region: TarH; pfam02203 290339006235 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290339006236 dimerization interface [polypeptide binding]; other site 290339006237 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 290339006238 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 290339006239 dimer interface [polypeptide binding]; other site 290339006240 putative CheW interface [polypeptide binding]; other site 290339006241 Phosphotransferase enzyme family; Region: APH; pfam01636 290339006242 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 290339006243 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 290339006244 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 290339006245 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290339006246 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339006247 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 290339006248 putative effector binding pocket; other site 290339006249 dimerization interface [polypeptide binding]; other site 290339006250 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 290339006251 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 290339006252 protein kinase; Region: PHA00451 290339006253 isocitrate dehydrogenase; Validated; Region: PRK07362 290339006254 isocitrate dehydrogenase; Reviewed; Region: PRK07006 290339006255 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 290339006256 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 290339006257 probable active site [active] 290339006258 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 290339006259 nudix motif; other site 290339006260 Cache domain; Region: Cache_1; pfam02743 290339006261 HAMP domain; Region: HAMP; pfam00672 290339006262 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 290339006263 dimer interface [polypeptide binding]; other site 290339006264 putative CheW interface [polypeptide binding]; other site 290339006265 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 290339006266 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 290339006267 putative lysogenization regulator; Reviewed; Region: PRK00218 290339006268 adenylosuccinate lyase; Provisional; Region: PRK09285 290339006269 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 290339006270 tetramer interface [polypeptide binding]; other site 290339006271 active site 290339006272 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 290339006273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290339006274 active site 290339006275 phosphorylation site [posttranslational modification] 290339006276 intermolecular recognition site; other site 290339006277 dimerization interface [polypeptide binding]; other site 290339006278 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290339006279 DNA binding site [nucleotide binding] 290339006280 sensor protein PhoQ; Provisional; Region: PRK10815 290339006281 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 290339006282 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 290339006283 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290339006284 ATP binding site [chemical binding]; other site 290339006285 Mg2+ binding site [ion binding]; other site 290339006286 G-X-G motif; other site 290339006287 Uncharacterized conserved protein [Function unknown]; Region: COG2850 290339006288 Cupin-like domain; Region: Cupin_8; pfam13621 290339006289 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 290339006290 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 290339006291 metal binding site [ion binding]; metal-binding site 290339006292 dimer interface [polypeptide binding]; other site 290339006293 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 290339006294 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290339006295 Walker A/P-loop; other site 290339006296 ATP binding site [chemical binding]; other site 290339006297 Q-loop/lid; other site 290339006298 ABC transporter signature motif; other site 290339006299 Walker B; other site 290339006300 D-loop; other site 290339006301 H-loop/switch region; other site 290339006302 TOBE domain; Region: TOBE_2; pfam08402 290339006303 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 290339006304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339006305 dimer interface [polypeptide binding]; other site 290339006306 conserved gate region; other site 290339006307 putative PBP binding loops; other site 290339006308 ABC-ATPase subunit interface; other site 290339006309 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 290339006310 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339006311 dimer interface [polypeptide binding]; other site 290339006312 conserved gate region; other site 290339006313 putative PBP binding loops; other site 290339006314 ABC-ATPase subunit interface; other site 290339006315 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 290339006316 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 290339006317 NAD-dependent deacetylase; Provisional; Region: PRK00481 290339006318 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 290339006319 NAD+ binding site [chemical binding]; other site 290339006320 substrate binding site [chemical binding]; other site 290339006321 Zn binding site [ion binding]; other site 290339006322 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 290339006323 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 290339006324 nucleotide binding site [chemical binding]; other site 290339006325 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 290339006326 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 290339006327 FtsX-like permease family; Region: FtsX; pfam02687 290339006328 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 290339006329 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 290339006330 Walker A/P-loop; other site 290339006331 ATP binding site [chemical binding]; other site 290339006332 Q-loop/lid; other site 290339006333 ABC transporter signature motif; other site 290339006334 Walker B; other site 290339006335 D-loop; other site 290339006336 H-loop/switch region; other site 290339006337 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 290339006338 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 290339006339 FtsX-like permease family; Region: FtsX; pfam02687 290339006340 transcription-repair coupling factor; Provisional; Region: PRK10689 290339006341 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 290339006342 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290339006343 ATP binding site [chemical binding]; other site 290339006344 putative Mg++ binding site [ion binding]; other site 290339006345 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290339006346 nucleotide binding region [chemical binding]; other site 290339006347 ATP-binding site [chemical binding]; other site 290339006348 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 290339006349 L,D-transpeptidase; Provisional; Region: PRK10190 290339006350 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 290339006351 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 290339006352 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 290339006353 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290339006354 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290339006355 hypothetical protein; Provisional; Region: PRK11280 290339006356 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 290339006357 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290339006358 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290339006359 hypothetical protein; Provisional; Region: PRK04940 290339006360 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 290339006361 beta-hexosaminidase; Provisional; Region: PRK05337 290339006362 thiamine kinase; Region: ycfN_thiK; TIGR02721 290339006363 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 290339006364 active site 290339006365 substrate binding site [chemical binding]; other site 290339006366 ATP binding site [chemical binding]; other site 290339006367 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 290339006368 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 290339006369 putative dimer interface [polypeptide binding]; other site 290339006370 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 290339006371 nucleotide binding site/active site [active] 290339006372 HIT family signature motif; other site 290339006373 catalytic residue [active] 290339006374 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 290339006375 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 290339006376 N-terminal plug; other site 290339006377 ligand-binding site [chemical binding]; other site 290339006378 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 290339006379 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 290339006380 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 290339006381 active site turn [active] 290339006382 phosphorylation site [posttranslational modification] 290339006383 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 290339006384 active site 290339006385 DNA polymerase III subunit delta'; Validated; Region: PRK07993 290339006386 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 290339006387 thymidylate kinase; Validated; Region: tmk; PRK00698 290339006388 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 290339006389 TMP-binding site; other site 290339006390 ATP-binding site [chemical binding]; other site 290339006391 conserved hypothetical protein, YceG family; Region: TIGR00247 290339006392 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 290339006393 dimerization interface [polypeptide binding]; other site 290339006394 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 290339006395 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 290339006396 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339006397 catalytic residue [active] 290339006398 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 290339006399 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 290339006400 dimer interface [polypeptide binding]; other site 290339006401 active site 290339006402 acyl carrier protein; Provisional; Region: acpP; PRK00982 290339006403 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 290339006404 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 290339006405 NAD(P) binding site [chemical binding]; other site 290339006406 homotetramer interface [polypeptide binding]; other site 290339006407 homodimer interface [polypeptide binding]; other site 290339006408 active site 290339006409 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 290339006410 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 290339006411 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 290339006412 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 290339006413 dimer interface [polypeptide binding]; other site 290339006414 active site 290339006415 CoA binding pocket [chemical binding]; other site 290339006416 putative phosphate acyltransferase; Provisional; Region: PRK05331 290339006417 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 290339006418 hypothetical protein; Provisional; Region: PRK11193 290339006419 Maf-like protein; Region: Maf; pfam02545 290339006420 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 290339006421 active site 290339006422 dimer interface [polypeptide binding]; other site 290339006423 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 290339006424 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 290339006425 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 290339006426 RNA binding surface [nucleotide binding]; other site 290339006427 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 290339006428 active site 290339006429 RNase e 5' UTR element 290339006430 ribonuclease E; Reviewed; Region: rne; PRK10811 290339006431 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 290339006432 homodimer interface [polypeptide binding]; other site 290339006433 oligonucleotide binding site [chemical binding]; other site 290339006434 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 290339006435 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290339006436 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339006437 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 290339006438 putative effector binding pocket; other site 290339006439 dimerization interface [polypeptide binding]; other site 290339006440 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 290339006441 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339006442 putative substrate translocation pore; other site 290339006443 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 290339006444 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 290339006445 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 290339006446 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 290339006447 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 290339006448 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 290339006449 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 290339006450 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 290339006451 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 290339006452 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 290339006453 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 290339006454 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 290339006455 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 290339006456 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 290339006457 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 290339006458 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 290339006459 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 290339006460 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 290339006461 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 290339006462 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 290339006463 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 290339006464 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 290339006465 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 290339006466 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 290339006467 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 290339006468 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 290339006469 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 290339006470 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 290339006471 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 290339006472 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 290339006473 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 290339006474 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 290339006475 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 290339006476 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 290339006477 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 290339006478 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 290339006479 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290339006480 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290339006481 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290339006482 hypothetical protein; Provisional; Region: PRK11239 290339006483 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 290339006484 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 290339006485 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 290339006486 multidrug resistance protein MdtH; Provisional; Region: PRK11646 290339006487 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339006488 putative substrate translocation pore; other site 290339006489 glutaredoxin 2; Provisional; Region: PRK10387 290339006490 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 290339006491 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 290339006492 N-terminal domain interface [polypeptide binding]; other site 290339006493 lipoprotein; Provisional; Region: PRK10598 290339006494 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 290339006495 active site 290339006496 substrate binding pocket [chemical binding]; other site 290339006497 dimer interface [polypeptide binding]; other site 290339006498 DNA damage-inducible protein I; Provisional; Region: PRK10597 290339006499 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 290339006500 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 290339006501 hydroxyglutarate oxidase; Provisional; Region: PRK11728 290339006502 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 290339006503 hypothetical protein; Provisional; Region: PRK03757 290339006504 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 290339006505 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 290339006506 active site residue [active] 290339006507 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 290339006508 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 290339006509 putative acyl-acceptor binding pocket; other site 290339006510 secY/secA suppressor protein; Provisional; Region: PRK11467 290339006511 lipoprotein; Provisional; Region: PRK10175 290339006512 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 290339006513 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 290339006514 Ligand binding site; other site 290339006515 DXD motif; other site 290339006516 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 290339006517 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 290339006518 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 290339006519 Acyltransferase family; Region: Acyl_transf_3; pfam01757 290339006520 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 290339006521 putative active site [active] 290339006522 catalytic site [active] 290339006523 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 290339006524 PLD-like domain; Region: PLDc_2; pfam13091 290339006525 putative active site [active] 290339006526 catalytic site [active] 290339006527 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 290339006528 putative ADP-ribose binding site [chemical binding]; other site 290339006529 putative active site [active] 290339006530 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 290339006531 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 290339006532 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 290339006533 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 290339006534 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 290339006535 GIY-YIG motif/motif A; other site 290339006536 active site 290339006537 catalytic site [active] 290339006538 metal binding site [ion binding]; metal-binding site 290339006539 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 290339006540 Putative phage tail protein; Region: Phage-tail_3; pfam13550 290339006541 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 290339006542 Interdomain contacts; other site 290339006543 Cytokine receptor motif; other site 290339006544 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 290339006545 Fibronectin type III protein; Region: DUF3672; pfam12421 290339006546 Phage capsid family; Region: Phage_capsid; pfam05065 290339006547 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 290339006548 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 290339006549 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 290339006550 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 290339006551 Protein of unknown function, DUF488; Region: DUF488; pfam04343 290339006552 Domain of unknown function (DUF4326); Region: DUF4326; pfam14216 290339006553 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290339006554 DEAD-like helicases superfamily; Region: DEXDc; smart00487 290339006555 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 290339006556 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 290339006557 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 290339006558 catalytic residues [active] 290339006559 catalytic nucleophile [active] 290339006560 Recombinase; Region: Recombinase; pfam07508 290339006561 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 290339006562 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 290339006563 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 290339006564 active site 290339006565 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 290339006566 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 290339006567 putative ligand binding site [chemical binding]; other site 290339006568 NAD binding site [chemical binding]; other site 290339006569 dimerization interface [polypeptide binding]; other site 290339006570 catalytic site [active] 290339006571 Fimbrial protein; Region: Fimbrial; cl01416 290339006572 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 290339006573 PapC N-terminal domain; Region: PapC_N; pfam13954 290339006574 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 290339006575 PapC C-terminal domain; Region: PapC_C; pfam13953 290339006576 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 290339006577 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 290339006578 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 290339006579 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 290339006580 putative oxidoreductase; Provisional; Region: PRK09939 290339006581 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 290339006582 putative molybdopterin cofactor binding site [chemical binding]; other site 290339006583 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 290339006584 putative molybdopterin cofactor binding site; other site 290339006585 hypothetical protein; Provisional; Region: PRK10536 290339006586 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 290339006587 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 290339006588 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 290339006589 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 290339006590 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 290339006591 Imelysin; Region: Peptidase_M75; pfam09375 290339006592 FTR1 family protein; Region: TIGR00145 290339006593 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 290339006594 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 290339006595 Nucleoside recognition; Region: Gate; pfam07670 290339006596 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 290339006597 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 290339006598 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 290339006599 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 290339006600 Na binding site [ion binding]; other site 290339006601 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 290339006602 Predicted transcriptional regulator [Transcription]; Region: COG3905 290339006603 Proline dehydrogenase; Region: Pro_dh; pfam01619 290339006604 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 290339006605 Glutamate binding site [chemical binding]; other site 290339006606 NAD binding site [chemical binding]; other site 290339006607 catalytic residues [active] 290339006608 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 290339006609 Protein of unknown function (DUF3289); Region: DUF3289; pfam11692 290339006610 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 290339006611 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290339006612 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 290339006613 pyrimidine utilization protein A; Region: RutA; TIGR03612 290339006614 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 290339006615 dimer interface [polypeptide binding]; other site 290339006616 active site 290339006617 non-prolyl cis peptide bond; other site 290339006618 insertion regions; other site 290339006619 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 290339006620 Isochorismatase family; Region: Isochorismatase; pfam00857 290339006621 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 290339006622 catalytic triad [active] 290339006623 conserved cis-peptide bond; other site 290339006624 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 290339006625 homotrimer interaction site [polypeptide binding]; other site 290339006626 putative active site [active] 290339006627 pyrimidine utilization protein D; Region: RutD; TIGR03611 290339006628 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 290339006629 putative FMN binding site [chemical binding]; other site 290339006630 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 290339006631 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 290339006632 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 290339006633 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 290339006634 hypothetical protein; Provisional; Region: PRK10174 290339006635 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 290339006636 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290339006637 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339006638 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290339006639 dimerization interface [polypeptide binding]; other site 290339006640 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 290339006641 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 290339006642 ImpA domain protein; Region: DUF3702; pfam12486 290339006643 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 290339006644 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 290339006645 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 290339006646 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 290339006647 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 290339006648 peptide binding site [polypeptide binding]; other site 290339006649 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 290339006650 YccA-like proteins; Region: YccA_like; cd10433 290339006651 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 290339006652 sulfur transfer protein TusE; Provisional; Region: PRK11508 290339006653 acylphosphatase; Provisional; Region: PRK14426 290339006654 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 290339006655 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 290339006656 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 290339006657 putative RNA binding site [nucleotide binding]; other site 290339006658 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290339006659 S-adenosylmethionine binding site [chemical binding]; other site 290339006660 heat shock protein HspQ; Provisional; Region: PRK14129 290339006661 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 290339006662 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 290339006663 active site 290339006664 dimer interfaces [polypeptide binding]; other site 290339006665 catalytic residues [active] 290339006666 DNA helicase IV; Provisional; Region: helD; PRK11054 290339006667 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 290339006668 Part of AAA domain; Region: AAA_19; pfam13245 290339006669 Family description; Region: UvrD_C_2; pfam13538 290339006670 Predicted membrane protein [Function unknown]; Region: COG3304 290339006671 Domain of unknown function (DUF307); Region: DUF307; pfam03733 290339006672 Domain of unknown function (DUF307); Region: DUF307; pfam03733 290339006673 TIGR01666 family membrane protein; Region: YCCS 290339006674 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 290339006675 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 290339006676 Prefoldin subunit; Region: Prefoldin_2; pfam01920 290339006677 TfoX N-terminal domain; Region: TfoX_N; pfam04993 290339006678 TfoX C-terminal domain; Region: TfoX_C; pfam04994 290339006679 SOS cell division inhibitor; Provisional; Region: PRK10595 290339006680 outer membrane protein A; Reviewed; Region: PRK10808 290339006681 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 290339006682 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 290339006683 ligand binding site [chemical binding]; other site 290339006684 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 290339006685 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 290339006686 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 290339006687 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 290339006688 active site 1 [active] 290339006689 dimer interface [polypeptide binding]; other site 290339006690 active site 2 [active] 290339006691 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 290339006692 Protein of unknown function (DUF330); Region: DUF330; pfam03886 290339006693 paraquat-inducible protein B; Provisional; Region: PRK10807 290339006694 mce related protein; Region: MCE; pfam02470 290339006695 mce related protein; Region: MCE; pfam02470 290339006696 mce related protein; Region: MCE; pfam02470 290339006697 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 290339006698 Paraquat-inducible protein A; Region: PqiA; pfam04403 290339006699 Paraquat-inducible protein A; Region: PqiA; pfam04403 290339006700 ABC transporter ATPase component; Reviewed; Region: PRK11147 290339006701 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290339006702 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290339006703 Walker A/P-loop; other site 290339006704 ATP binding site [chemical binding]; other site 290339006705 Q-loop/lid; other site 290339006706 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290339006707 ABC transporter signature motif; other site 290339006708 Walker B; other site 290339006709 D-loop; other site 290339006710 ABC transporter; Region: ABC_tran_2; pfam12848 290339006711 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290339006712 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 290339006713 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 290339006714 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 290339006715 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290339006716 S-adenosylmethionine binding site [chemical binding]; other site 290339006717 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 290339006718 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 290339006719 MOSC domain; Region: MOSC; pfam03473 290339006720 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 290339006721 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 290339006722 catalytic loop [active] 290339006723 iron binding site [ion binding]; other site 290339006724 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 290339006725 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 290339006726 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 290339006727 quinone interaction residues [chemical binding]; other site 290339006728 active site 290339006729 catalytic residues [active] 290339006730 FMN binding site [chemical binding]; other site 290339006731 substrate binding site [chemical binding]; other site 290339006732 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 290339006733 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 290339006734 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 290339006735 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290339006736 substrate binding pocket [chemical binding]; other site 290339006737 membrane-bound complex binding site; other site 290339006738 hinge residues; other site 290339006739 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 290339006740 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 290339006741 active site 290339006742 dimer interface [polypeptide binding]; other site 290339006743 non-prolyl cis peptide bond; other site 290339006744 insertion regions; other site 290339006745 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 290339006746 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339006747 dimer interface [polypeptide binding]; other site 290339006748 conserved gate region; other site 290339006749 putative PBP binding loops; other site 290339006750 ABC-ATPase subunit interface; other site 290339006751 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 290339006752 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 290339006753 Walker A/P-loop; other site 290339006754 ATP binding site [chemical binding]; other site 290339006755 Q-loop/lid; other site 290339006756 ABC transporter signature motif; other site 290339006757 Walker B; other site 290339006758 D-loop; other site 290339006759 H-loop/switch region; other site 290339006760 aminopeptidase N; Provisional; Region: pepN; PRK14015 290339006761 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 290339006762 active site 290339006763 Zn binding site [ion binding]; other site 290339006764 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 290339006765 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 290339006766 active site 290339006767 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 290339006768 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 290339006769 putative anticodon binding site; other site 290339006770 putative dimer interface [polypeptide binding]; other site 290339006771 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 290339006772 homodimer interface [polypeptide binding]; other site 290339006773 motif 1; other site 290339006774 motif 2; other site 290339006775 active site 290339006776 motif 3; other site 290339006777 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 290339006778 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 290339006779 trimer interface [polypeptide binding]; other site 290339006780 eyelet of channel; other site 290339006781 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 290339006782 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290339006783 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339006784 homodimer interface [polypeptide binding]; other site 290339006785 catalytic residue [active] 290339006786 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 290339006787 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 290339006788 Peptidase M15; Region: Peptidase_M15_3; cl01194 290339006789 murein L,D-transpeptidase; Provisional; Region: PRK10594 290339006790 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 290339006791 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 290339006792 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 290339006793 cell division protein MukB; Provisional; Region: mukB; PRK04863 290339006794 P-loop containing region of AAA domain; Region: AAA_29; cl17516 290339006795 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 290339006796 condesin subunit E; Provisional; Region: PRK05256 290339006797 condesin subunit F; Provisional; Region: PRK05260 290339006798 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290339006799 S-adenosylmethionine binding site [chemical binding]; other site 290339006800 Methyltransferase domain; Region: Methyltransf_31; pfam13847 290339006801 Uncharacterized conserved protein [Function unknown]; Region: COG1434 290339006802 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 290339006803 putative active site [active] 290339006804 hypothetical protein; Provisional; Region: PRK10593 290339006805 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 290339006806 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 290339006807 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 290339006808 AsnC family; Region: AsnC_trans_reg; pfam01037 290339006809 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 290339006810 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 290339006811 Ligand binding site; other site 290339006812 oligomer interface; other site 290339006813 Trm112p-like protein; Region: Trm112p; cl01066 290339006814 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 290339006815 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 290339006816 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 290339006817 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 290339006818 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 290339006819 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 290339006820 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 290339006821 Walker A/P-loop; other site 290339006822 ATP binding site [chemical binding]; other site 290339006823 Q-loop/lid; other site 290339006824 ABC transporter signature motif; other site 290339006825 Walker B; other site 290339006826 D-loop; other site 290339006827 H-loop/switch region; other site 290339006828 ComEC family competence protein; Provisional; Region: PRK11539 290339006829 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 290339006830 Competence protein; Region: Competence; pfam03772 290339006831 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 290339006832 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 290339006833 IHF dimer interface [polypeptide binding]; other site 290339006834 IHF - DNA interface [nucleotide binding]; other site 290339006835 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 290339006836 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 290339006837 RNA binding site [nucleotide binding]; other site 290339006838 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 290339006839 RNA binding site [nucleotide binding]; other site 290339006840 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 290339006841 RNA binding site [nucleotide binding]; other site 290339006842 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 290339006843 RNA binding site [nucleotide binding]; other site 290339006844 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 290339006845 RNA binding site [nucleotide binding]; other site 290339006846 cytidylate kinase; Provisional; Region: cmk; PRK00023 290339006847 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 290339006848 CMP-binding site; other site 290339006849 The sites determining sugar specificity; other site 290339006850 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 290339006851 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 290339006852 hinge; other site 290339006853 active site 290339006854 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 290339006855 homodimer interface [polypeptide binding]; other site 290339006856 substrate-cofactor binding pocket; other site 290339006857 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339006858 catalytic residue [active] 290339006859 Predicted membrane protein [Function unknown]; Region: COG2323 290339006860 uncharacterized domain; Region: TIGR00702 290339006861 YcaO-like family; Region: YcaO; pfam02624 290339006862 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 290339006863 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 290339006864 Pyruvate formate lyase 1; Region: PFL1; cd01678 290339006865 coenzyme A binding site [chemical binding]; other site 290339006866 active site 290339006867 catalytic residues [active] 290339006868 glycine loop; other site 290339006869 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 290339006870 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290339006871 FeS/SAM binding site; other site 290339006872 putative MFS family transporter protein; Provisional; Region: PRK03633 290339006873 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339006874 putative substrate translocation pore; other site 290339006875 seryl-tRNA synthetase; Provisional; Region: PRK05431 290339006876 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 290339006877 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 290339006878 dimer interface [polypeptide binding]; other site 290339006879 active site 290339006880 motif 1; other site 290339006881 motif 2; other site 290339006882 motif 3; other site 290339006883 recombination factor protein RarA; Reviewed; Region: PRK13342 290339006884 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290339006885 Walker A motif; other site 290339006886 ATP binding site [chemical binding]; other site 290339006887 Walker B motif; other site 290339006888 arginine finger; other site 290339006889 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 290339006890 periplasmic chaperone LolA; Region: lolA; TIGR00547 290339006891 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 290339006892 DNA translocase FtsK; Provisional; Region: PRK10263 290339006893 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 290339006894 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 290339006895 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 290339006896 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 290339006897 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290339006898 putative DNA binding site [nucleotide binding]; other site 290339006899 putative Zn2+ binding site [ion binding]; other site 290339006900 AsnC family; Region: AsnC_trans_reg; pfam01037 290339006901 thioredoxin reductase; Provisional; Region: PRK10262 290339006902 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290339006903 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290339006904 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 290339006905 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 290339006906 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290339006907 Walker A/P-loop; other site 290339006908 ATP binding site [chemical binding]; other site 290339006909 Q-loop/lid; other site 290339006910 ABC transporter signature motif; other site 290339006911 Walker B; other site 290339006912 D-loop; other site 290339006913 H-loop/switch region; other site 290339006914 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 290339006915 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 290339006916 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 290339006917 Walker A/P-loop; other site 290339006918 ATP binding site [chemical binding]; other site 290339006919 Q-loop/lid; other site 290339006920 ABC transporter signature motif; other site 290339006921 Walker B; other site 290339006922 D-loop; other site 290339006923 H-loop/switch region; other site 290339006924 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 290339006925 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 290339006926 rRNA binding site [nucleotide binding]; other site 290339006927 predicted 30S ribosome binding site; other site 290339006928 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 290339006929 Clp amino terminal domain; Region: Clp_N; pfam02861 290339006930 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290339006931 Walker A motif; other site 290339006932 ATP binding site [chemical binding]; other site 290339006933 Walker B motif; other site 290339006934 arginine finger; other site 290339006935 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290339006936 Walker A motif; other site 290339006937 ATP binding site [chemical binding]; other site 290339006938 Walker B motif; other site 290339006939 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 290339006940 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 290339006941 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 290339006942 DNA-binding site [nucleotide binding]; DNA binding site 290339006943 RNA-binding motif; other site 290339006944 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 290339006945 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 290339006946 Walker A/P-loop; other site 290339006947 ATP binding site [chemical binding]; other site 290339006948 Q-loop/lid; other site 290339006949 ABC transporter signature motif; other site 290339006950 Walker B; other site 290339006951 D-loop; other site 290339006952 H-loop/switch region; other site 290339006953 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 290339006954 FtsX-like permease family; Region: FtsX; pfam02687 290339006955 macrolide transporter subunit MacA; Provisional; Region: PRK11578 290339006956 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 290339006957 HlyD family secretion protein; Region: HlyD_3; pfam13437 290339006958 Protein of unknown function (DUF535); Region: DUF535; pfam04393 290339006959 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 290339006960 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 290339006961 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 290339006962 putative active site [active] 290339006963 putative metal-binding site [ion binding]; other site 290339006964 Predicted membrane protein [Function unknown]; Region: COG2431 290339006965 hybrid cluster protein; Provisional; Region: PRK05290 290339006966 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 290339006967 ACS interaction site; other site 290339006968 CODH interaction site; other site 290339006969 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 290339006970 hybrid metal cluster; other site 290339006971 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 290339006972 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 290339006973 FAD binding pocket [chemical binding]; other site 290339006974 FAD binding motif [chemical binding]; other site 290339006975 phosphate binding motif [ion binding]; other site 290339006976 beta-alpha-beta structure motif; other site 290339006977 NAD binding pocket [chemical binding]; other site 290339006978 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 290339006979 catalytic loop [active] 290339006980 iron binding site [ion binding]; other site 290339006981 pyruvate dehydrogenase; Provisional; Region: PRK09124 290339006982 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 290339006983 PYR/PP interface [polypeptide binding]; other site 290339006984 dimer interface [polypeptide binding]; other site 290339006985 tetramer interface [polypeptide binding]; other site 290339006986 TPP binding site [chemical binding]; other site 290339006987 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 290339006988 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 290339006989 TPP-binding site [chemical binding]; other site 290339006990 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 290339006991 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 290339006992 tetramer interface [polypeptide binding]; other site 290339006993 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339006994 catalytic residue [active] 290339006995 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290339006996 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290339006997 NAD(P) binding site [chemical binding]; other site 290339006998 active site 290339006999 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 290339007000 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 290339007001 amidase catalytic site [active] 290339007002 Zn binding residues [ion binding]; other site 290339007003 substrate binding site [chemical binding]; other site 290339007004 hypothetical protein; Provisional; Region: PRK02877 290339007005 putative lipoprotein; Provisional; Region: PRK10533 290339007006 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 290339007007 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290339007008 Walker A/P-loop; other site 290339007009 ATP binding site [chemical binding]; other site 290339007010 Q-loop/lid; other site 290339007011 ABC transporter signature motif; other site 290339007012 Walker B; other site 290339007013 D-loop; other site 290339007014 H-loop/switch region; other site 290339007015 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 290339007016 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290339007017 substrate binding pocket [chemical binding]; other site 290339007018 membrane-bound complex binding site; other site 290339007019 hinge residues; other site 290339007020 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 290339007021 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339007022 dimer interface [polypeptide binding]; other site 290339007023 conserved gate region; other site 290339007024 putative PBP binding loops; other site 290339007025 ABC-ATPase subunit interface; other site 290339007026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339007027 dimer interface [polypeptide binding]; other site 290339007028 conserved gate region; other site 290339007029 putative PBP binding loops; other site 290339007030 ABC-ATPase subunit interface; other site 290339007031 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 290339007032 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290339007033 substrate binding pocket [chemical binding]; other site 290339007034 membrane-bound complex binding site; other site 290339007035 hinge residues; other site 290339007036 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 290339007037 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 290339007038 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 290339007039 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339007040 dimer interface [polypeptide binding]; other site 290339007041 conserved gate region; other site 290339007042 putative PBP binding loops; other site 290339007043 ABC-ATPase subunit interface; other site 290339007044 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339007045 dimer interface [polypeptide binding]; other site 290339007046 conserved gate region; other site 290339007047 putative PBP binding loops; other site 290339007048 ABC-ATPase subunit interface; other site 290339007049 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 290339007050 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 290339007051 Walker A/P-loop; other site 290339007052 ATP binding site [chemical binding]; other site 290339007053 Q-loop/lid; other site 290339007054 ABC transporter signature motif; other site 290339007055 Walker B; other site 290339007056 D-loop; other site 290339007057 H-loop/switch region; other site 290339007058 TOBE domain; Region: TOBE_2; pfam08402 290339007059 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 290339007060 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 290339007061 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 290339007062 RimK-like ATP-grasp domain; Region: RimK; pfam08443 290339007063 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 290339007064 dimer interface [polypeptide binding]; other site 290339007065 FMN binding site [chemical binding]; other site 290339007066 NADPH bind site [chemical binding]; other site 290339007067 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 290339007068 putative transporter; Provisional; Region: PRK04972 290339007069 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 290339007070 TrkA-C domain; Region: TrkA_C; pfam02080 290339007071 TrkA-C domain; Region: TrkA_C; pfam02080 290339007072 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 290339007073 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290339007074 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 290339007075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339007076 putative substrate translocation pore; other site 290339007077 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 290339007078 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 290339007079 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 290339007080 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290339007081 active site 290339007082 motif I; other site 290339007083 motif II; other site 290339007084 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290339007085 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 290339007086 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339007087 putative substrate translocation pore; other site 290339007088 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 290339007089 active site 290339007090 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 290339007091 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 290339007092 active site 290339007093 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 290339007094 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 290339007095 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 290339007096 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 290339007097 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 290339007098 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 290339007099 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 290339007100 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 290339007101 putative C-terminal domain interface [polypeptide binding]; other site 290339007102 putative GSH binding site (G-site) [chemical binding]; other site 290339007103 putative dimer interface [polypeptide binding]; other site 290339007104 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 290339007105 putative N-terminal domain interface [polypeptide binding]; other site 290339007106 putative dimer interface [polypeptide binding]; other site 290339007107 putative substrate binding pocket (H-site) [chemical binding]; other site 290339007108 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 290339007109 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 290339007110 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 290339007111 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 290339007112 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290339007113 FeS/SAM binding site; other site 290339007114 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 290339007115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339007116 dimer interface [polypeptide binding]; other site 290339007117 conserved gate region; other site 290339007118 putative PBP binding loops; other site 290339007119 ABC-ATPase subunit interface; other site 290339007120 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 290339007121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339007122 dimer interface [polypeptide binding]; other site 290339007123 conserved gate region; other site 290339007124 putative PBP binding loops; other site 290339007125 ABC-ATPase subunit interface; other site 290339007126 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 290339007127 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 290339007128 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 290339007129 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290339007130 Walker A/P-loop; other site 290339007131 ATP binding site [chemical binding]; other site 290339007132 Q-loop/lid; other site 290339007133 ABC transporter signature motif; other site 290339007134 Walker B; other site 290339007135 D-loop; other site 290339007136 H-loop/switch region; other site 290339007137 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 290339007138 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290339007139 Walker A/P-loop; other site 290339007140 ATP binding site [chemical binding]; other site 290339007141 Q-loop/lid; other site 290339007142 ABC transporter signature motif; other site 290339007143 Walker B; other site 290339007144 D-loop; other site 290339007145 H-loop/switch region; other site 290339007146 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 290339007147 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 290339007148 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 290339007149 dimer interface [polypeptide binding]; other site 290339007150 putative functional site; other site 290339007151 putative MPT binding site; other site 290339007152 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 290339007153 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 290339007154 ATP binding site [chemical binding]; other site 290339007155 substrate interface [chemical binding]; other site 290339007156 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290339007157 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290339007158 DNA binding site [nucleotide binding] 290339007159 domain linker motif; other site 290339007160 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290339007161 ligand binding site [chemical binding]; other site 290339007162 dimerization interface [polypeptide binding]; other site 290339007163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339007164 D-galactonate transporter; Region: 2A0114; TIGR00893 290339007165 putative substrate translocation pore; other site 290339007166 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 290339007167 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 290339007168 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 290339007169 putative active site [active] 290339007170 putative catalytic site [active] 290339007171 haemagglutination activity domain; Region: Haemagg_act; pfam05860 290339007172 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 290339007173 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290339007174 Walker A/P-loop; other site 290339007175 ATP binding site [chemical binding]; other site 290339007176 Q-loop/lid; other site 290339007177 ABC transporter signature motif; other site 290339007178 Walker B; other site 290339007179 D-loop; other site 290339007180 H-loop/switch region; other site 290339007181 ABC transporter; Region: ABC_tran_2; pfam12848 290339007182 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290339007183 L,D-transpeptidase; Provisional; Region: PRK10260 290339007184 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 290339007185 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 290339007186 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 290339007187 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339007188 putative substrate translocation pore; other site 290339007189 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339007190 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 290339007191 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 290339007192 HlyD family secretion protein; Region: HlyD_3; pfam13437 290339007193 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 290339007194 transmembrane helices; other site 290339007195 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 290339007196 manganese transport regulator MntR; Provisional; Region: PRK11050 290339007197 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 290339007198 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 290339007199 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 290339007200 Sulfatase; Region: Sulfatase; pfam00884 290339007201 outer membrane protein X; Provisional; Region: ompX; PRK09408 290339007202 threonine and homoserine efflux system; Provisional; Region: PRK10532 290339007203 EamA-like transporter family; Region: EamA; pfam00892 290339007204 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 290339007205 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 290339007206 dimerization interface [polypeptide binding]; other site 290339007207 DPS ferroxidase diiron center [ion binding]; other site 290339007208 ion pore; other site 290339007209 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 290339007210 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290339007211 substrate binding pocket [chemical binding]; other site 290339007212 membrane-bound complex binding site; other site 290339007213 hinge residues; other site 290339007214 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 290339007215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339007216 dimer interface [polypeptide binding]; other site 290339007217 conserved gate region; other site 290339007218 putative PBP binding loops; other site 290339007219 ABC-ATPase subunit interface; other site 290339007220 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 290339007221 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 290339007222 Walker A/P-loop; other site 290339007223 ATP binding site [chemical binding]; other site 290339007224 Q-loop/lid; other site 290339007225 ABC transporter signature motif; other site 290339007226 Walker B; other site 290339007227 D-loop; other site 290339007228 H-loop/switch region; other site 290339007229 putative mechanosensitive channel protein; Provisional; Region: PRK11465 290339007230 Mechanosensitive ion channel; Region: MS_channel; pfam00924 290339007231 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 290339007232 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290339007233 S-adenosylmethionine binding site [chemical binding]; other site 290339007234 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 290339007235 hypothetical protein; Provisional; Region: PRK11019 290339007236 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 290339007237 glycosyl transferase family protein; Provisional; Region: PRK08136 290339007238 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 290339007239 Fimbrial protein; Region: Fimbrial; cl01416 290339007240 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 290339007241 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 290339007242 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 290339007243 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 290339007244 PapC N-terminal domain; Region: PapC_N; pfam13954 290339007245 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 290339007246 PapC C-terminal domain; Region: PapC_C; pfam13953 290339007247 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 290339007248 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 290339007249 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 290339007250 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 290339007251 DEAD_2; Region: DEAD_2; pfam06733 290339007252 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 290339007253 transcriptional antiterminator BglG; Provisional; Region: PRK09772 290339007254 CAT RNA binding domain; Region: CAT_RBD; smart01061 290339007255 PRD domain; Region: PRD; pfam00874 290339007256 PRD domain; Region: PRD; pfam00874 290339007257 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 290339007258 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 290339007259 active site turn [active] 290339007260 phosphorylation site [posttranslational modification] 290339007261 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 290339007262 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 290339007263 HPr interaction site; other site 290339007264 glycerol kinase (GK) interaction site [polypeptide binding]; other site 290339007265 active site 290339007266 phosphorylation site [posttranslational modification] 290339007267 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 290339007268 beta-galactosidase; Region: BGL; TIGR03356 290339007269 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 290339007270 beta-galactosidase; Region: BGL; TIGR03356 290339007271 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 290339007272 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 290339007273 ATP binding site [chemical binding]; other site 290339007274 Mg++ binding site [ion binding]; other site 290339007275 motif III; other site 290339007276 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290339007277 nucleotide binding region [chemical binding]; other site 290339007278 ATP-binding site [chemical binding]; other site 290339007279 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 290339007280 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290339007281 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 290339007282 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 290339007283 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 290339007284 HlyD family secretion protein; Region: HlyD_3; pfam13437 290339007285 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 290339007286 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 290339007287 Walker A/P-loop; other site 290339007288 ATP binding site [chemical binding]; other site 290339007289 Q-loop/lid; other site 290339007290 ABC transporter signature motif; other site 290339007291 Walker B; other site 290339007292 D-loop; other site 290339007293 H-loop/switch region; other site 290339007294 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 290339007295 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 290339007296 Walker A/P-loop; other site 290339007297 ATP binding site [chemical binding]; other site 290339007298 Q-loop/lid; other site 290339007299 ABC transporter signature motif; other site 290339007300 Walker B; other site 290339007301 D-loop; other site 290339007302 H-loop/switch region; other site 290339007303 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 290339007304 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 290339007305 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 290339007306 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 290339007307 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 290339007308 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 290339007309 putative catalytic site [active] 290339007310 putative metal binding site [ion binding]; other site 290339007311 putative phosphate binding site [ion binding]; other site 290339007312 cardiolipin synthase 2; Provisional; Region: PRK11263 290339007313 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 290339007314 putative active site [active] 290339007315 catalytic site [active] 290339007316 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 290339007317 putative active site [active] 290339007318 catalytic site [active] 290339007319 Predicted integral membrane protein [Function unknown]; Region: COG0392 290339007320 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 290339007321 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 290339007322 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 290339007323 MoaE homodimer interface [polypeptide binding]; other site 290339007324 MoaD interaction [polypeptide binding]; other site 290339007325 active site residues [active] 290339007326 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 290339007327 MoaE interaction surface [polypeptide binding]; other site 290339007328 MoeB interaction surface [polypeptide binding]; other site 290339007329 thiocarboxylated glycine; other site 290339007330 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 290339007331 trimer interface [polypeptide binding]; other site 290339007332 dimer interface [polypeptide binding]; other site 290339007333 putative active site [active] 290339007334 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 290339007335 MPT binding site; other site 290339007336 trimer interface [polypeptide binding]; other site 290339007337 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 290339007338 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290339007339 FeS/SAM binding site; other site 290339007340 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 290339007341 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 290339007342 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 290339007343 phosphate binding site [ion binding]; other site 290339007344 putative substrate binding pocket [chemical binding]; other site 290339007345 dimer interface [polypeptide binding]; other site 290339007346 excinuclease ABC subunit B; Provisional; Region: PRK05298 290339007347 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290339007348 ATP binding site [chemical binding]; other site 290339007349 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290339007350 nucleotide binding region [chemical binding]; other site 290339007351 ATP-binding site [chemical binding]; other site 290339007352 Ultra-violet resistance protein B; Region: UvrB; pfam12344 290339007353 UvrB/uvrC motif; Region: UVR; pfam02151 290339007354 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 290339007355 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290339007356 Walker A/P-loop; other site 290339007357 ATP binding site [chemical binding]; other site 290339007358 Q-loop/lid; other site 290339007359 ABC transporter signature motif; other site 290339007360 Walker B; other site 290339007361 D-loop; other site 290339007362 H-loop/switch region; other site 290339007363 AAA domain; Region: AAA_26; pfam13500 290339007364 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 290339007365 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 290339007366 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290339007367 S-adenosylmethionine binding site [chemical binding]; other site 290339007368 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 290339007369 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 290339007370 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290339007371 catalytic residue [active] 290339007372 biotin synthase; Provisional; Region: PRK15108 290339007373 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290339007374 FeS/SAM binding site; other site 290339007375 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 290339007376 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 290339007377 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 290339007378 inhibitor-cofactor binding pocket; inhibition site 290339007379 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339007380 catalytic residue [active] 290339007381 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 290339007382 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 290339007383 potential catalytic triad [active] 290339007384 conserved cys residue [active] 290339007385 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 290339007386 substrate binding site [chemical binding]; other site 290339007387 acyl-CoA thioesterase; Provisional; Region: PRK10531 290339007388 putative pectinesterase; Region: PLN02432; cl01911 290339007389 6-phosphogluconolactonase; Provisional; Region: PRK11028 290339007390 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 290339007391 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290339007392 active site 290339007393 motif I; other site 290339007394 motif II; other site 290339007395 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290339007396 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 290339007397 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290339007398 Walker A/P-loop; other site 290339007399 ATP binding site [chemical binding]; other site 290339007400 Q-loop/lid; other site 290339007401 ABC transporter signature motif; other site 290339007402 Walker B; other site 290339007403 D-loop; other site 290339007404 H-loop/switch region; other site 290339007405 molybdenum-pterin binding domain; Region: Mop; TIGR00638 290339007406 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 290339007407 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339007408 dimer interface [polypeptide binding]; other site 290339007409 conserved gate region; other site 290339007410 putative PBP binding loops; other site 290339007411 ABC-ATPase subunit interface; other site 290339007412 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 290339007413 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290339007414 substrate binding pocket [chemical binding]; other site 290339007415 membrane-bound complex binding site; other site 290339007416 hinge residues; other site 290339007417 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 290339007418 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 290339007419 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 290339007420 molybdenum-pterin binding domain; Region: Mop; TIGR00638 290339007421 TOBE domain; Region: TOBE; pfam03459 290339007422 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 290339007423 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 290339007424 Walker A/P-loop; other site 290339007425 ATP binding site [chemical binding]; other site 290339007426 Q-loop/lid; other site 290339007427 ABC transporter signature motif; other site 290339007428 Walker B; other site 290339007429 D-loop; other site 290339007430 H-loop/switch region; other site 290339007431 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290339007432 Walker A/P-loop; other site 290339007433 ATP binding site [chemical binding]; other site 290339007434 Q-loop/lid; other site 290339007435 ABC transporter signature motif; other site 290339007436 Walker B; other site 290339007437 D-loop; other site 290339007438 H-loop/switch region; other site 290339007439 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 290339007440 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 290339007441 NAD binding site [chemical binding]; other site 290339007442 homodimer interface [polypeptide binding]; other site 290339007443 active site 290339007444 substrate binding site [chemical binding]; other site 290339007445 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 290339007446 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 290339007447 dimer interface [polypeptide binding]; other site 290339007448 active site 290339007449 galactokinase; Provisional; Region: PRK05101 290339007450 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 290339007451 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 290339007452 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 290339007453 active site 290339007454 catalytic residues [active] 290339007455 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290339007456 catalytic core [active] 290339007457 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290339007458 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 290339007459 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 290339007460 zinc transporter ZitB; Provisional; Region: PRK03557 290339007461 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 290339007462 quinolinate synthetase; Provisional; Region: PRK09375 290339007463 tol-pal system protein YbgF; Provisional; Region: PRK10803 290339007464 Tetratricopeptide repeat; Region: TPR_6; pfam13174 290339007465 Tetratricopeptide repeat; Region: TPR_6; pfam13174 290339007466 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 290339007467 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 290339007468 ligand binding site [chemical binding]; other site 290339007469 translocation protein TolB; Provisional; Region: tolB; PRK03629 290339007470 TolB amino-terminal domain; Region: TolB_N; pfam04052 290339007471 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 290339007472 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 290339007473 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 290339007474 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 290339007475 TolA C-terminal; Region: TolA; pfam06519 290339007476 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 290339007477 colicin uptake protein TolR; Provisional; Region: PRK11024 290339007478 colicin uptake protein TolQ; Provisional; Region: PRK10801 290339007479 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 290339007480 active site 290339007481 hypothetical protein; Provisional; Region: PRK10588 290339007482 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 290339007483 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 290339007484 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 290339007485 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 290339007486 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 290339007487 alpha-mannosidase; Provisional; Region: PRK09819 290339007488 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 290339007489 active site 290339007490 metal binding site [ion binding]; metal-binding site 290339007491 catalytic site [active] 290339007492 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 290339007493 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 290339007494 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 290339007495 active site 290339007496 phosphorylation site [posttranslational modification] 290339007497 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 290339007498 active site 290339007499 P-loop; other site 290339007500 phosphorylation site [posttranslational modification] 290339007501 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 290339007502 DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764 290339007503 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290339007504 DNA-binding site [nucleotide binding]; DNA binding site 290339007505 UTRA domain; Region: UTRA; pfam07702 290339007506 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 290339007507 CoA binding domain; Region: CoA_binding; smart00881 290339007508 CoA-ligase; Region: Ligase_CoA; pfam00549 290339007509 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 290339007510 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 290339007511 CoA-ligase; Region: Ligase_CoA; pfam00549 290339007512 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 290339007513 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 290339007514 E3 interaction surface; other site 290339007515 lipoyl attachment site [posttranslational modification]; other site 290339007516 e3 binding domain; Region: E3_binding; pfam02817 290339007517 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 290339007518 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 290339007519 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 290339007520 TPP-binding site [chemical binding]; other site 290339007521 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 290339007522 dimer interface [polypeptide binding]; other site 290339007523 PYR/PP interface [polypeptide binding]; other site 290339007524 TPP binding site [chemical binding]; other site 290339007525 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 290339007526 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 290339007527 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 290339007528 L-aspartate oxidase; Provisional; Region: PRK06175 290339007529 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 290339007530 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 290339007531 SdhC subunit interface [polypeptide binding]; other site 290339007532 proximal heme binding site [chemical binding]; other site 290339007533 cardiolipin binding site; other site 290339007534 Iron-sulfur protein interface; other site 290339007535 proximal quinone binding site [chemical binding]; other site 290339007536 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 290339007537 Iron-sulfur protein interface; other site 290339007538 proximal quinone binding site [chemical binding]; other site 290339007539 SdhD (CybS) interface [polypeptide binding]; other site 290339007540 proximal heme binding site [chemical binding]; other site 290339007541 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 290339007542 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 290339007543 dimer interface [polypeptide binding]; other site 290339007544 active site 290339007545 citrylCoA binding site [chemical binding]; other site 290339007546 NADH binding [chemical binding]; other site 290339007547 cationic pore residues; other site 290339007548 oxalacetate/citrate binding site [chemical binding]; other site 290339007549 coenzyme A binding site [chemical binding]; other site 290339007550 catalytic triad [active] 290339007551 endonuclease VIII; Provisional; Region: PRK10445 290339007552 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 290339007553 DNA binding site [nucleotide binding] 290339007554 catalytic residue [active] 290339007555 putative catalytic residues [active] 290339007556 H2TH interface [polypeptide binding]; other site 290339007557 intercalation triad [nucleotide binding]; other site 290339007558 substrate specificity determining residue; other site 290339007559 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 290339007560 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 290339007561 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 290339007562 Predicted membrane protein [Function unknown]; Region: COG3817 290339007563 Protein of unknown function (DUF979); Region: DUF979; pfam06166 290339007564 Protein of unknown function (DUF969); Region: DUF969; pfam06149 290339007565 MarR family; Region: MarR_2; cl17246 290339007566 LamB/YcsF family protein; Provisional; Region: PRK05406 290339007567 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 290339007568 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 290339007569 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 290339007570 Uncharacterized conserved protein [Function unknown]; Region: COG0327 290339007571 metal-binding protein; Provisional; Region: PRK10799 290339007572 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 290339007573 DNA photolyase; Region: DNA_photolyase; pfam00875 290339007574 Protein of unknown function (DUF523); Region: DUF523; pfam04463 290339007575 Uncharacterized conserved protein [Function unknown]; Region: COG3272 290339007576 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 290339007577 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 290339007578 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 290339007579 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 290339007580 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290339007581 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 290339007582 sensor protein KdpD; Provisional; Region: PRK10490 290339007583 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 290339007584 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 290339007585 Ligand Binding Site [chemical binding]; other site 290339007586 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 290339007587 GAF domain; Region: GAF_3; pfam13492 290339007588 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290339007589 dimer interface [polypeptide binding]; other site 290339007590 phosphorylation site [posttranslational modification] 290339007591 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290339007592 ATP binding site [chemical binding]; other site 290339007593 Mg2+ binding site [ion binding]; other site 290339007594 G-X-G motif; other site 290339007595 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 290339007596 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290339007597 active site 290339007598 phosphorylation site [posttranslational modification] 290339007599 intermolecular recognition site; other site 290339007600 dimerization interface [polypeptide binding]; other site 290339007601 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290339007602 DNA binding site [nucleotide binding] 290339007603 ornithine decarboxylase; Provisional; Region: PRK13578 290339007604 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 290339007605 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 290339007606 homodimer interface [polypeptide binding]; other site 290339007607 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339007608 catalytic residue [active] 290339007609 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 290339007610 putrescine transporter; Provisional; Region: potE; PRK10655 290339007611 phosphoglucomutase; Validated; Region: PRK07564 290339007612 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 290339007613 active site 290339007614 substrate binding site [chemical binding]; other site 290339007615 metal binding site [ion binding]; metal-binding site 290339007616 replication initiation regulator SeqA; Provisional; Region: PRK11187 290339007617 acyl-CoA esterase; Provisional; Region: PRK10673 290339007618 PGAP1-like protein; Region: PGAP1; pfam07819 290339007619 LexA regulated protein; Provisional; Region: PRK11675 290339007620 flavodoxin FldA; Validated; Region: PRK09267 290339007621 ferric uptake regulator; Provisional; Region: fur; PRK09462 290339007622 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 290339007623 metal binding site 2 [ion binding]; metal-binding site 290339007624 putative DNA binding helix; other site 290339007625 metal binding site 1 [ion binding]; metal-binding site 290339007626 dimer interface [polypeptide binding]; other site 290339007627 structural Zn2+ binding site [ion binding]; other site 290339007628 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 290339007629 Putative carbohydrate binding domain; Region: CHB_HEX; smart01081 290339007630 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 290339007631 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 290339007632 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a...; Region: GH20_Sm-chitobiase-like; cd06569 290339007633 active site 290339007634 C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847 290339007635 outer membrane porin, OprD family; Region: OprD; pfam03573 290339007636 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 290339007637 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290339007638 active site 290339007639 HIGH motif; other site 290339007640 nucleotide binding site [chemical binding]; other site 290339007641 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 290339007642 KMSKS motif; other site 290339007643 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 290339007644 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 290339007645 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 290339007646 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 290339007647 active site turn [active] 290339007648 phosphorylation site [posttranslational modification] 290339007649 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 290339007650 HPr interaction site; other site 290339007651 glycerol kinase (GK) interaction site [polypeptide binding]; other site 290339007652 active site 290339007653 phosphorylation site [posttranslational modification] 290339007654 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 290339007655 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 290339007656 active site 290339007657 trimer interface [polypeptide binding]; other site 290339007658 allosteric site; other site 290339007659 active site lid [active] 290339007660 hexamer (dimer of trimers) interface [polypeptide binding]; other site 290339007661 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 290339007662 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 290339007663 active site 290339007664 dimer interface [polypeptide binding]; other site 290339007665 MarR family; Region: MarR; pfam01047 290339007666 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 290339007667 ROK family; Region: ROK; pfam00480 290339007668 UMP phosphatase; Provisional; Region: PRK10444 290339007669 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290339007670 active site 290339007671 motif I; other site 290339007672 motif II; other site 290339007673 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290339007674 asparagine synthetase B; Provisional; Region: asnB; PRK09431 290339007675 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 290339007676 active site 290339007677 dimer interface [polypeptide binding]; other site 290339007678 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 290339007679 Ligand Binding Site [chemical binding]; other site 290339007680 Molecular Tunnel; other site 290339007681 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 290339007682 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 290339007683 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 290339007684 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 290339007685 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290339007686 FeS/SAM binding site; other site 290339007687 TRAM domain; Region: TRAM; pfam01938 290339007688 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 290339007689 PhoH-like protein; Region: PhoH; pfam02562 290339007690 metal-binding heat shock protein; Provisional; Region: PRK00016 290339007691 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 290339007692 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 290339007693 Transporter associated domain; Region: CorC_HlyC; smart01091 290339007694 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 290339007695 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 290339007696 putative active site [active] 290339007697 catalytic triad [active] 290339007698 putative dimer interface [polypeptide binding]; other site 290339007699 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 290339007700 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290339007701 substrate binding pocket [chemical binding]; other site 290339007702 membrane-bound complex binding site; other site 290339007703 hinge residues; other site 290339007704 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 290339007705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339007706 dimer interface [polypeptide binding]; other site 290339007707 conserved gate region; other site 290339007708 putative PBP binding loops; other site 290339007709 ABC-ATPase subunit interface; other site 290339007710 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 290339007711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339007712 dimer interface [polypeptide binding]; other site 290339007713 conserved gate region; other site 290339007714 putative PBP binding loops; other site 290339007715 ABC-ATPase subunit interface; other site 290339007716 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 290339007717 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 290339007718 Walker A/P-loop; other site 290339007719 ATP binding site [chemical binding]; other site 290339007720 Q-loop/lid; other site 290339007721 ABC transporter signature motif; other site 290339007722 Walker B; other site 290339007723 D-loop; other site 290339007724 H-loop/switch region; other site 290339007725 hypothetical protein; Provisional; Region: PRK11032 290339007726 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 290339007727 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 290339007728 HIGH motif; other site 290339007729 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 290339007730 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290339007731 active site 290339007732 KMSKS motif; other site 290339007733 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 290339007734 tRNA binding surface [nucleotide binding]; other site 290339007735 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 290339007736 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 290339007737 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 290339007738 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 290339007739 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 290339007740 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 290339007741 active site 290339007742 (T/H)XGH motif; other site 290339007743 ribosome-associated protein; Provisional; Region: PRK11538 290339007744 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 290339007745 penicillin-binding protein 2; Provisional; Region: PRK10795 290339007746 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 290339007747 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 290339007748 cell wall shape-determining protein; Provisional; Region: PRK10794 290339007749 rare lipoprotein A; Provisional; Region: PRK10672 290339007750 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 290339007751 Sporulation related domain; Region: SPOR; pfam05036 290339007752 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 290339007753 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 290339007754 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 290339007755 hypothetical protein; Provisional; Region: PRK04998 290339007756 lipoate-protein ligase B; Provisional; Region: PRK14342 290339007757 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 290339007758 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339007759 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 290339007760 substrate binding pocket [chemical binding]; other site 290339007761 dimerization interface [polypeptide binding]; other site 290339007762 lipoyl synthase; Provisional; Region: PRK05481 290339007763 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290339007764 FeS/SAM binding site; other site 290339007765 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 290339007766 Predicted amidohydrolase [General function prediction only]; Region: COG0388 290339007767 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 290339007768 putative active site [active] 290339007769 catalytic triad [active] 290339007770 putative dimer interface [polypeptide binding]; other site 290339007771 chromosome condensation membrane protein; Provisional; Region: PRK14196 290339007772 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 290339007773 DNA-binding site [nucleotide binding]; DNA binding site 290339007774 RNA-binding motif; other site 290339007775 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 290339007776 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 290339007777 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 290339007778 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 290339007779 B1 nucleotide binding pocket [chemical binding]; other site 290339007780 B2 nucleotide binding pocket [chemical binding]; other site 290339007781 CAS motifs; other site 290339007782 active site 290339007783 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 290339007784 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 290339007785 Ca binding site [ion binding]; other site 290339007786 active site 290339007787 catalytic site [active] 290339007788 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 290339007789 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 290339007790 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 290339007791 Ca binding site [ion binding]; other site 290339007792 active site 290339007793 catalytic site [active] 290339007794 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 290339007795 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 290339007796 Walker A/P-loop; other site 290339007797 ATP binding site [chemical binding]; other site 290339007798 Q-loop/lid; other site 290339007799 ABC transporter signature motif; other site 290339007800 Walker B; other site 290339007801 D-loop; other site 290339007802 H-loop/switch region; other site 290339007803 TOBE domain; Region: TOBE_2; pfam08402 290339007804 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290339007805 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339007806 dimer interface [polypeptide binding]; other site 290339007807 conserved gate region; other site 290339007808 putative PBP binding loops; other site 290339007809 ABC-ATPase subunit interface; other site 290339007810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339007811 dimer interface [polypeptide binding]; other site 290339007812 conserved gate region; other site 290339007813 putative PBP binding loops; other site 290339007814 ABC-ATPase subunit interface; other site 290339007815 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290339007816 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290339007817 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 290339007818 fructuronate transporter; Provisional; Region: PRK10034; cl15264 290339007819 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 290339007820 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 290339007821 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 290339007822 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 290339007823 NAD binding site [chemical binding]; other site 290339007824 catalytic Zn binding site [ion binding]; other site 290339007825 structural Zn binding site [ion binding]; other site 290339007826 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290339007827 Ligand Binding Site [chemical binding]; other site 290339007828 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 290339007829 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 290339007830 catalytic residue [active] 290339007831 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 290339007832 catalytic residues [active] 290339007833 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290339007834 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290339007835 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 290339007836 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 290339007837 dimer interface [polypeptide binding]; other site 290339007838 decamer (pentamer of dimers) interface [polypeptide binding]; other site 290339007839 catalytic triad [active] 290339007840 peroxidatic and resolving cysteines [active] 290339007841 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 290339007842 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339007843 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290339007844 dimerization interface [polypeptide binding]; other site 290339007845 methionine aminotransferase; Validated; Region: PRK09082 290339007846 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290339007847 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339007848 homodimer interface [polypeptide binding]; other site 290339007849 catalytic residue [active] 290339007850 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 290339007851 intersubunit interface [polypeptide binding]; other site 290339007852 active site 290339007853 Zn2+ binding site [ion binding]; other site 290339007854 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 290339007855 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 290339007856 Cupin domain; Region: Cupin_2; cl17218 290339007857 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 290339007858 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 290339007859 acyl-activating enzyme (AAE) consensus motif; other site 290339007860 AMP binding site [chemical binding]; other site 290339007861 MbtH-like protein; Region: MbtH; smart00923 290339007862 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 290339007863 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 290339007864 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 290339007865 outer membrane receptor FepA; Provisional; Region: PRK13524 290339007866 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 290339007867 N-terminal plug; other site 290339007868 ligand-binding site [chemical binding]; other site 290339007869 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 290339007870 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 290339007871 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 290339007872 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 290339007873 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 290339007874 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 290339007875 Nitrate and nitrite sensing; Region: NIT; pfam08376 290339007876 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 290339007877 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 290339007878 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 290339007879 dimer interface [polypeptide binding]; other site 290339007880 putative CheW interface [polypeptide binding]; other site 290339007881 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 290339007882 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 290339007883 ImpE protein; Region: ImpE; pfam07024 290339007884 PAAR motif; Region: PAAR_motif; pfam05488 290339007885 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 290339007886 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 290339007887 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 290339007888 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 290339007889 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 290339007890 Phage terminase large subunit; Region: Terminase_3; cl12054 290339007891 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 290339007892 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 290339007893 catalytic residues [active] 290339007894 Antitermination protein; Region: Antiterm; pfam03589 290339007895 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 290339007896 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 290339007897 Endodeoxyribonuclease RusA; Region: RusA; cl01885 290339007898 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 290339007899 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 290339007900 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 290339007901 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 290339007902 homodimer interface [polypeptide binding]; other site 290339007903 NADP binding site [chemical binding]; other site 290339007904 substrate binding site [chemical binding]; other site 290339007905 ribosome-associated protein; Provisional; Region: PRK11507 290339007906 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 290339007907 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 290339007908 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 290339007909 active site turn [active] 290339007910 phosphorylation site [posttranslational modification] 290339007911 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 290339007912 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290339007913 DNA binding site [nucleotide binding] 290339007914 domain linker motif; other site 290339007915 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 290339007916 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 290339007917 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 290339007918 active site 290339007919 HIGH motif; other site 290339007920 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 290339007921 KMSKS motif; other site 290339007922 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 290339007923 tRNA binding surface [nucleotide binding]; other site 290339007924 anticodon binding site; other site 290339007925 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 290339007926 substrate binding site [chemical binding]; other site 290339007927 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 290339007928 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 290339007929 putative active site [active] 290339007930 putative metal binding site [ion binding]; other site 290339007931 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 290339007932 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 290339007933 ATP-grasp domain; Region: ATP-grasp; pfam02222 290339007934 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 290339007935 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 290339007936 homodimer interface [polypeptide binding]; other site 290339007937 substrate-cofactor binding pocket; other site 290339007938 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339007939 catalytic residue [active] 290339007940 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 290339007941 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 290339007942 dimer interface [polypeptide binding]; other site 290339007943 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339007944 catalytic residue [active] 290339007945 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 290339007946 FOG: CBS domain [General function prediction only]; Region: COG0517 290339007947 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 290339007948 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 290339007949 active site residue [active] 290339007950 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 290339007951 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 290339007952 FtsX-like permease family; Region: FtsX; pfam02687 290339007953 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 290339007954 Walker A/P-loop; other site 290339007955 ATP binding site [chemical binding]; other site 290339007956 ABC transporter; Region: ABC_tran; pfam00005 290339007957 Q-loop/lid; other site 290339007958 ABC transporter signature motif; other site 290339007959 Walker B; other site 290339007960 D-loop; other site 290339007961 H-loop/switch region; other site 290339007962 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 290339007963 active site 290339007964 catalytic triad [active] 290339007965 oxyanion hole [active] 290339007966 switch loop; other site 290339007967 oxidoreductase; Provisional; Region: PRK08017 290339007968 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 290339007969 NADP binding site [chemical binding]; other site 290339007970 active site 290339007971 steroid binding site; other site 290339007972 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 290339007973 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 290339007974 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 290339007975 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 290339007976 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 290339007977 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 290339007978 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 290339007979 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 290339007980 DNA binding residues [nucleotide binding] 290339007981 dimer interface [polypeptide binding]; other site 290339007982 copper binding site [ion binding]; other site 290339007983 copper exporting ATPase; Provisional; Region: copA; PRK10671 290339007984 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 290339007985 metal-binding site [ion binding] 290339007986 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 290339007987 metal-binding site [ion binding] 290339007988 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290339007989 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290339007990 active site 290339007991 motif I; other site 290339007992 motif II; other site 290339007993 TraB family; Region: TraB; cl12050 290339007994 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 290339007995 putative deacylase active site [active] 290339007996 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 290339007997 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 290339007998 active site 290339007999 metal binding site [ion binding]; metal-binding site 290339008000 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 290339008001 putative cation:proton antiport protein; Provisional; Region: PRK10669 290339008002 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 290339008003 TrkA-N domain; Region: TrkA_N; pfam02254 290339008004 inosine/guanosine kinase; Provisional; Region: PRK15074 290339008005 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290339008006 ferrochelatase; Reviewed; Region: hemH; PRK00035 290339008007 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 290339008008 C-terminal domain interface [polypeptide binding]; other site 290339008009 active site 290339008010 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 290339008011 active site 290339008012 N-terminal domain interface [polypeptide binding]; other site 290339008013 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 290339008014 fructuronate transporter; Provisional; Region: PRK10034; cl15264 290339008015 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 290339008016 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 290339008017 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 290339008018 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 290339008019 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 290339008020 adenylate kinase; Reviewed; Region: adk; PRK00279 290339008021 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 290339008022 AMP-binding site [chemical binding]; other site 290339008023 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 290339008024 heat shock protein 90; Provisional; Region: PRK05218 290339008025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290339008026 ATP binding site [chemical binding]; other site 290339008027 Mg2+ binding site [ion binding]; other site 290339008028 G-X-G motif; other site 290339008029 recombination protein RecR; Reviewed; Region: recR; PRK00076 290339008030 RecR protein; Region: RecR; pfam02132 290339008031 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 290339008032 putative active site [active] 290339008033 putative metal-binding site [ion binding]; other site 290339008034 tetramer interface [polypeptide binding]; other site 290339008035 putative major fimbrial protein SthE; Provisional; Region: PRK15292 290339008036 Fimbrial protein; Region: Fimbrial; pfam00419 290339008037 putative fimbrial protein SthD; Provisional; Region: PRK15293 290339008038 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 290339008039 PapC N-terminal domain; Region: PapC_N; pfam13954 290339008040 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 290339008041 PapC C-terminal domain; Region: PapC_C; pfam13953 290339008042 fimbrial assembly chaperone SthB; Provisional; Region: PRK15295 290339008043 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 290339008044 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 290339008045 putative fimbrial protein SthA; Provisional; Region: PRK15296 290339008046 hypothetical protein; Validated; Region: PRK00153 290339008047 Dnax ribosomal frameshifting element 290339008048 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290339008049 active site 290339008050 hypothetical protein; Provisional; Region: PRK10527 290339008051 Primosomal replication protein priB and priC; Region: priB_priC; pfam07445 290339008052 Protein of unknown function (DUF2496); Region: DUF2496; pfam10689 290339008053 hypothetical protein; Provisional; Region: PRK11281 290339008054 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 290339008055 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 290339008056 Mechanosensitive ion channel; Region: MS_channel; pfam00924 290339008057 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 290339008058 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290339008059 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 290339008060 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 290339008061 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 290339008062 HlyD family secretion protein; Region: HlyD_3; pfam13437 290339008063 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 290339008064 Protein export membrane protein; Region: SecD_SecF; cl14618 290339008065 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 290339008066 Hha toxicity attenuator; Provisional; Region: PRK10667 290339008067 gene expression modulator; Provisional; Region: PRK10945 290339008068 maltose O-acetyltransferase; Provisional; Region: PRK10092 290339008069 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 290339008070 active site 290339008071 substrate binding site [chemical binding]; other site 290339008072 trimer interface [polypeptide binding]; other site 290339008073 CoA binding site [chemical binding]; other site 290339008074 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 290339008075 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 290339008076 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 290339008077 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 290339008078 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 290339008079 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 290339008080 dimer interface [polypeptide binding]; other site 290339008081 putative CheW interface [polypeptide binding]; other site 290339008082 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 290339008083 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 290339008084 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 290339008085 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 290339008086 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 290339008087 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 290339008088 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 290339008089 Walker A/P-loop; other site 290339008090 ATP binding site [chemical binding]; other site 290339008091 Q-loop/lid; other site 290339008092 ABC transporter signature motif; other site 290339008093 Walker B; other site 290339008094 D-loop; other site 290339008095 H-loop/switch region; other site 290339008096 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339008097 dimer interface [polypeptide binding]; other site 290339008098 conserved gate region; other site 290339008099 ABC-ATPase subunit interface; other site 290339008100 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 290339008101 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 290339008102 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290339008103 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290339008104 Coenzyme A binding pocket [chemical binding]; other site 290339008105 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 290339008106 Predicted membrane protein [Function unknown]; Region: COG2364 290339008107 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 290339008108 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 290339008109 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290339008110 DNA-binding site [nucleotide binding]; DNA binding site 290339008111 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290339008112 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339008113 homodimer interface [polypeptide binding]; other site 290339008114 catalytic residue [active] 290339008115 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 290339008116 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 290339008117 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 290339008118 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 290339008119 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 290339008120 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 290339008121 CT1975-like protein; Region: Cas_CT1975; pfam09344 290339008122 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 290339008123 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 290339008124 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 290339008125 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 290339008126 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 290339008127 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 290339008128 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 290339008129 DNA binding site [nucleotide binding] 290339008130 active site 290339008131 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 290339008132 acyl-CoA thioesterase II; Provisional; Region: PRK10526 290339008133 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 290339008134 active site 290339008135 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 290339008136 catalytic triad [active] 290339008137 dimer interface [polypeptide binding]; other site 290339008138 ammonium transporter; Provisional; Region: PRK10666 290339008139 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 290339008140 Nitrogen regulatory protein P-II; Region: P-II; smart00938 290339008141 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 290339008142 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 290339008143 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290339008144 Walker A/P-loop; other site 290339008145 ATP binding site [chemical binding]; other site 290339008146 Q-loop/lid; other site 290339008147 ABC transporter signature motif; other site 290339008148 Walker B; other site 290339008149 D-loop; other site 290339008150 H-loop/switch region; other site 290339008151 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 290339008152 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 290339008153 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290339008154 Walker A/P-loop; other site 290339008155 ATP binding site [chemical binding]; other site 290339008156 Q-loop/lid; other site 290339008157 ABC transporter signature motif; other site 290339008158 Walker B; other site 290339008159 D-loop; other site 290339008160 H-loop/switch region; other site 290339008161 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 290339008162 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290339008163 putative DNA binding site [nucleotide binding]; other site 290339008164 putative Zn2+ binding site [ion binding]; other site 290339008165 AsnC family; Region: AsnC_trans_reg; pfam01037 290339008166 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 290339008167 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 290339008168 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290339008169 catalytic residue [active] 290339008170 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 290339008171 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 290339008172 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 290339008173 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290339008174 active site 290339008175 motif I; other site 290339008176 motif II; other site 290339008177 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290339008178 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 290339008179 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 290339008180 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 290339008181 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 290339008182 Ligand Binding Site [chemical binding]; other site 290339008183 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 290339008184 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 290339008185 active site 290339008186 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 290339008187 periplasmic folding chaperone; Provisional; Region: PRK10788 290339008188 SurA N-terminal domain; Region: SurA_N_3; cl07813 290339008189 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 290339008190 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 290339008191 IHF dimer interface [polypeptide binding]; other site 290339008192 IHF - DNA interface [nucleotide binding]; other site 290339008193 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 290339008194 Found in ATP-dependent protease La (LON); Region: LON; smart00464 290339008195 Found in ATP-dependent protease La (LON); Region: LON; smart00464 290339008196 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290339008197 Walker A motif; other site 290339008198 ATP binding site [chemical binding]; other site 290339008199 Walker B motif; other site 290339008200 arginine finger; other site 290339008201 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 290339008202 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 290339008203 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 290339008204 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290339008205 Walker A motif; other site 290339008206 ATP binding site [chemical binding]; other site 290339008207 Walker B motif; other site 290339008208 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 290339008209 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 290339008210 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 290339008211 oligomer interface [polypeptide binding]; other site 290339008212 active site residues [active] 290339008213 trigger factor; Provisional; Region: tig; PRK01490 290339008214 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 290339008215 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 290339008216 transcriptional regulator BolA; Provisional; Region: PRK11628 290339008217 hypothetical protein; Provisional; Region: PRK11627 290339008218 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 290339008219 muropeptide transporter; Reviewed; Region: ampG; PRK11902 290339008220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339008221 putative substrate translocation pore; other site 290339008222 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 290339008223 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 290339008224 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 290339008225 nucleotide binding site [chemical binding]; other site 290339008226 putative NEF/HSP70 interaction site [polypeptide binding]; other site 290339008227 SBD interface [polypeptide binding]; other site 290339008228 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 290339008229 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 290339008230 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 290339008231 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 290339008232 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 290339008233 D-pathway; other site 290339008234 Putative ubiquinol binding site [chemical binding]; other site 290339008235 Low-spin heme (heme b) binding site [chemical binding]; other site 290339008236 Putative water exit pathway; other site 290339008237 Binuclear center (heme o3/CuB) [ion binding]; other site 290339008238 K-pathway; other site 290339008239 Putative proton exit pathway; other site 290339008240 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 290339008241 Subunit I/III interface [polypeptide binding]; other site 290339008242 Subunit III/IV interface [polypeptide binding]; other site 290339008243 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 290339008244 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 290339008245 UbiA prenyltransferase family; Region: UbiA; pfam01040 290339008246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339008247 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290339008248 putative substrate translocation pore; other site 290339008249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 290339008250 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 290339008251 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 290339008252 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 290339008253 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 290339008254 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 290339008255 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 290339008256 conserved cys residue [active] 290339008257 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 290339008258 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 290339008259 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 290339008260 Ligand Binding Site [chemical binding]; other site 290339008261 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 290339008262 active site residue [active] 290339008263 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 290339008264 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 290339008265 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 290339008266 substrate binding pocket [chemical binding]; other site 290339008267 chain length determination region; other site 290339008268 substrate-Mg2+ binding site; other site 290339008269 catalytic residues [active] 290339008270 aspartate-rich region 1; other site 290339008271 active site lid residues [active] 290339008272 aspartate-rich region 2; other site 290339008273 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 290339008274 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 290339008275 TPP-binding site; other site 290339008276 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 290339008277 PYR/PP interface [polypeptide binding]; other site 290339008278 dimer interface [polypeptide binding]; other site 290339008279 TPP binding site [chemical binding]; other site 290339008280 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290339008281 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290339008282 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290339008283 active site 290339008284 catalytic tetrad [active] 290339008285 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 290339008286 tetramer interfaces [polypeptide binding]; other site 290339008287 binuclear metal-binding site [ion binding]; other site 290339008288 thiamine monophosphate kinase; Provisional; Region: PRK05731 290339008289 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 290339008290 ATP binding site [chemical binding]; other site 290339008291 dimerization interface [polypeptide binding]; other site 290339008292 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 290339008293 putative RNA binding site [nucleotide binding]; other site 290339008294 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 290339008295 homopentamer interface [polypeptide binding]; other site 290339008296 active site 290339008297 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 290339008298 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 290339008299 catalytic motif [active] 290339008300 Zn binding site [ion binding]; other site 290339008301 RibD C-terminal domain; Region: RibD_C; cl17279 290339008302 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 290339008303 ATP cone domain; Region: ATP-cone; pfam03477 290339008304 hypothetical protein; Provisional; Region: PRK11530 290339008305 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 290339008306 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 290339008307 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 290339008308 Protein export membrane protein; Region: SecD_SecF; pfam02355 290339008309 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 290339008310 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 290339008311 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 290339008312 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 290339008313 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 290339008314 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 290339008315 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 290339008316 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 290339008317 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 290339008318 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 290339008319 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 290339008320 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 290339008321 maltodextrin glucosidase; Provisional; Region: PRK10785 290339008322 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 290339008323 homodimer interface [polypeptide binding]; other site 290339008324 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 290339008325 active site 290339008326 homodimer interface [polypeptide binding]; other site 290339008327 catalytic site [active] 290339008328 putative proline-specific permease; Provisional; Region: proY; PRK10580 290339008329 Spore germination protein; Region: Spore_permease; cl17796 290339008330 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 290339008331 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 290339008332 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 290339008333 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290339008334 putative active site [active] 290339008335 heme pocket [chemical binding]; other site 290339008336 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290339008337 dimer interface [polypeptide binding]; other site 290339008338 phosphorylation site [posttranslational modification] 290339008339 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290339008340 ATP binding site [chemical binding]; other site 290339008341 Mg2+ binding site [ion binding]; other site 290339008342 G-X-G motif; other site 290339008343 transcriptional regulator PhoB; Provisional; Region: PRK10161 290339008344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290339008345 active site 290339008346 phosphorylation site [posttranslational modification] 290339008347 intermolecular recognition site; other site 290339008348 dimerization interface [polypeptide binding]; other site 290339008349 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290339008350 DNA binding site [nucleotide binding] 290339008351 exonuclease subunit SbcD; Provisional; Region: PRK10966 290339008352 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 290339008353 active site 290339008354 metal binding site [ion binding]; metal-binding site 290339008355 DNA binding site [nucleotide binding] 290339008356 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 290339008357 exonuclease subunit SbcC; Provisional; Region: PRK10246 290339008358 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290339008359 Walker A/P-loop; other site 290339008360 ATP binding site [chemical binding]; other site 290339008361 Q-loop/lid; other site 290339008362 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290339008363 ABC transporter signature motif; other site 290339008364 Walker B; other site 290339008365 D-loop; other site 290339008366 H-loop/switch region; other site 290339008367 fructokinase; Reviewed; Region: PRK09557 290339008368 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 290339008369 nucleotide binding site [chemical binding]; other site 290339008370 recombination associated protein; Reviewed; Region: rdgC; PRK00321 290339008371 hypothetical protein; Provisional; Region: PRK10579 290339008372 hypothetical protein; Provisional; Region: PRK10481 290339008373 hypothetical protein; Provisional; Region: PRK10380 290339008374 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 290339008375 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 290339008376 ADP binding site [chemical binding]; other site 290339008377 magnesium binding site [ion binding]; other site 290339008378 putative shikimate binding site; other site 290339008379 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 290339008380 hypothetical protein; Validated; Region: PRK00124 290339008381 Predicted membrane protein [Function unknown]; Region: COG2323 290339008382 pyrroline-5-carboxylate reductase; Region: PLN02688 290339008383 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 290339008384 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 290339008385 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339008386 putative substrate translocation pore; other site 290339008387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339008388 anti-RssB factor; Provisional; Region: PRK10244 290339008389 drug efflux system protein MdtG; Provisional; Region: PRK09874 290339008390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339008391 putative substrate translocation pore; other site 290339008392 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 290339008393 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 290339008394 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 290339008395 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 290339008396 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 290339008397 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 290339008398 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 290339008399 microcin B17 transporter; Reviewed; Region: PRK11098 290339008400 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 290339008401 Isochorismatase family; Region: Isochorismatase; pfam00857 290339008402 catalytic triad [active] 290339008403 conserved cis-peptide bond; other site 290339008404 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 290339008405 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 290339008406 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 290339008407 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 290339008408 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 290339008409 Autotransporter beta-domain; Region: Autotransporter; pfam03797 290339008410 Competence-damaged protein; Region: CinA; pfam02464 290339008411 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 290339008412 dimer interface [polypeptide binding]; other site 290339008413 active site 290339008414 Schiff base residues; other site 290339008415 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 290339008416 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 290339008417 putative acyl-acceptor binding pocket; other site 290339008418 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 290339008419 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 290339008420 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 290339008421 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 290339008422 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339008423 dimer interface [polypeptide binding]; other site 290339008424 conserved gate region; other site 290339008425 putative PBP binding loops; other site 290339008426 ABC-ATPase subunit interface; other site 290339008427 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 290339008428 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 290339008429 Walker A/P-loop; other site 290339008430 ATP binding site [chemical binding]; other site 290339008431 Q-loop/lid; other site 290339008432 ABC transporter signature motif; other site 290339008433 Walker B; other site 290339008434 D-loop; other site 290339008435 H-loop/switch region; other site 290339008436 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 290339008437 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290339008438 substrate binding pocket [chemical binding]; other site 290339008439 membrane-bound complex binding site; other site 290339008440 hinge residues; other site 290339008441 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 290339008442 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 290339008443 S-methylmethionine transporter; Provisional; Region: PRK11387 290339008444 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 290339008445 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 290339008446 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 290339008447 4Fe-4S binding domain; Region: Fer4; pfam00037 290339008448 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 290339008449 [4Fe-4S] binding site [ion binding]; other site 290339008450 molybdopterin cofactor binding site; other site 290339008451 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 290339008452 molybdopterin cofactor binding site; other site 290339008453 Uncharacterized conserved protein [Function unknown]; Region: COG2427 290339008454 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 290339008455 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 290339008456 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 290339008457 Hok/gef family; Region: HOK_GEF; pfam01848 290339008458 Predicted ATPase [General function prediction only]; Region: COG1485 290339008459 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 290339008460 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 290339008461 putative acyl-acceptor binding pocket; other site 290339008462 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 290339008463 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 290339008464 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 290339008465 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 290339008466 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 290339008467 dimer interface [polypeptide binding]; other site 290339008468 ADP-ribose binding site [chemical binding]; other site 290339008469 active site 290339008470 nudix motif; other site 290339008471 metal binding site [ion binding]; metal-binding site 290339008472 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 290339008473 EAL domain; Region: EAL; pfam00563 290339008474 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 290339008475 active site clefts [active] 290339008476 zinc binding site [ion binding]; other site 290339008477 dimer interface [polypeptide binding]; other site 290339008478 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 290339008479 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 290339008480 Sulfate transporter family; Region: Sulfate_transp; pfam00916 290339008481 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 290339008482 Domain of unknown function DUF20; Region: UPF0118; pfam01594 290339008483 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 290339008484 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 290339008485 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 290339008486 Trp docking motif [polypeptide binding]; other site 290339008487 putative active site [active] 290339008488 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290339008489 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339008490 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 290339008491 putative effector binding pocket; other site 290339008492 dimerization interface [polypeptide binding]; other site 290339008493 Protein of unknown function, DUF606; Region: DUF606; pfam04657 290339008494 Protein of unknown function, DUF606; Region: DUF606; pfam04657 290339008495 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290339008496 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339008497 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290339008498 dimerization interface [polypeptide binding]; other site 290339008499 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; pfam05870 290339008500 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 290339008501 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 290339008502 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 290339008503 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 290339008504 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 290339008505 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339008506 dimer interface [polypeptide binding]; other site 290339008507 conserved gate region; other site 290339008508 putative PBP binding loops; other site 290339008509 ABC-ATPase subunit interface; other site 290339008510 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 290339008511 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 290339008512 Walker A/P-loop; other site 290339008513 ATP binding site [chemical binding]; other site 290339008514 Q-loop/lid; other site 290339008515 ABC transporter signature motif; other site 290339008516 Walker B; other site 290339008517 D-loop; other site 290339008518 H-loop/switch region; other site 290339008519 NIL domain; Region: NIL; pfam09383 290339008520 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 290339008521 malate dehydrogenase; Provisional; Region: PRK13529 290339008522 Malic enzyme, N-terminal domain; Region: malic; pfam00390 290339008523 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 290339008524 NAD(P) binding site [chemical binding]; other site 290339008525 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 290339008526 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339008527 putative substrate translocation pore; other site 290339008528 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 290339008529 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 290339008530 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 290339008531 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 290339008532 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 290339008533 lac repressor; Reviewed; Region: lacI; PRK09526 290339008534 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290339008535 DNA binding site [nucleotide binding] 290339008536 domain linker motif; other site 290339008537 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 290339008538 ligand binding site [chemical binding]; other site 290339008539 dimerization interface (open form) [polypeptide binding]; other site 290339008540 dimerization interface (closed form) [polypeptide binding]; other site 290339008541 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 290339008542 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290339008543 NAD(P) binding site [chemical binding]; other site 290339008544 active site 290339008545 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290339008546 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290339008547 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 290339008548 homotrimer interaction site [polypeptide binding]; other site 290339008549 putative active site [active] 290339008550 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 290339008551 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 290339008552 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 290339008553 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 290339008554 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 290339008555 conserved cys residue [active] 290339008556 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290339008557 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290339008558 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 290339008559 Protein of unknown function (DUF3289); Region: DUF3289; pfam11692 290339008560 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 290339008561 active site 290339008562 dimer interface [polypeptide binding]; other site 290339008563 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 290339008564 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 290339008565 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 290339008566 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 290339008567 pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079 290339008568 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 290339008569 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290339008570 FeS/SAM binding site; other site 290339008571 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 290339008572 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 290339008573 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 290339008574 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 290339008575 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 290339008576 peptide binding site [polypeptide binding]; other site 290339008577 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 290339008578 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 290339008579 metal binding site [ion binding]; metal-binding site 290339008580 dimer interface [polypeptide binding]; other site 290339008581 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 290339008582 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 290339008583 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 290339008584 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 290339008585 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 290339008586 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290339008587 active site 290339008588 DNA protecting protein DprA; Region: dprA; TIGR00732 290339008589 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 290339008590 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 290339008591 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 290339008592 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 290339008593 active site 290339008594 metal binding site [ion binding]; metal-binding site 290339008595 interdomain interaction site; other site 290339008596 Domain of unknown function (DUF927); Region: DUF927; pfam06048 290339008597 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 290339008598 Helix-turn-helix domain; Region: HTH_17; pfam12728 290339008599 integrase; Provisional; Region: PRK09692 290339008600 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 290339008601 active site 290339008602 Int/Topo IB signature motif; other site 290339008603 Predicted membrane protein [Function unknown]; Region: COG2246 290339008604 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 290339008605 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 290339008606 Ligand binding site; other site 290339008607 Putative Catalytic site; other site 290339008608 DXD motif; other site 290339008609 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 290339008610 Phage-related protein, tail component [Function unknown]; Region: COG4733 290339008611 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 290339008612 Phage-related minor tail protein [Function unknown]; Region: COG5281 290339008613 tape measure domain; Region: tape_meas_nterm; TIGR02675 290339008614 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 290339008615 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 290339008616 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290339008617 active site 290339008618 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 290339008619 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 290339008620 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 290339008621 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 290339008622 Terminase-like family; Region: Terminase_6; pfam03237 290339008623 Uncharacterized conserved protein [Function unknown]; Region: COG5323 290339008624 Terminase small subunit; Region: Terminase_2; pfam03592 290339008625 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 290339008626 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 290339008627 catalytic residues [active] 290339008628 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 290339008629 NinF protein; Region: NinF; pfam05810 290339008630 Protein of unknown function (DUF2591); Region: DUF2591; pfam10765 290339008631 NinB protein; Region: NinB; pfam05772 290339008632 Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961 290339008633 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 290339008634 Protein of unknown function (DUF551); Region: DUF551; pfam04448 290339008635 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 290339008636 phage replicative helicase, DnaB family, HK022 subfamily; Region: phage_DnaB; TIGR03600 290339008637 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 290339008638 Walker A motif; other site 290339008639 ATP binding site [chemical binding]; other site 290339008640 Walker B motif; other site 290339008641 Bacteriophage CII protein; Region: Phage_CII; pfam05269 290339008642 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290339008643 non-specific DNA binding site [nucleotide binding]; other site 290339008644 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 290339008645 salt bridge; other site 290339008646 sequence-specific DNA binding site [nucleotide binding]; other site 290339008647 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 290339008648 Catalytic site [active] 290339008649 cIII protein family; Region: cIII; pfam08134 290339008650 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 290339008651 ERF superfamily; Region: ERF; pfam04404 290339008652 Protein of unknown function (DUF2737); Region: DUF2737; pfam10930 290339008653 integrase; Provisional; Region: int; PHA02601 290339008654 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 290339008655 Int/Topo IB signature motif; other site 290339008656 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 290339008657 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 290339008658 putative catalytic cysteine [active] 290339008659 gamma-glutamyl kinase; Provisional; Region: PRK05429 290339008660 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 290339008661 nucleotide binding site [chemical binding]; other site 290339008662 homotetrameric interface [polypeptide binding]; other site 290339008663 putative phosphate binding site [ion binding]; other site 290339008664 putative allosteric binding site; other site 290339008665 PUA domain; Region: PUA; pfam01472 290339008666 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 290339008667 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 290339008668 trimer interface [polypeptide binding]; other site 290339008669 eyelet of channel; other site 290339008670 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 290339008671 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 290339008672 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290339008673 active site 290339008674 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 290339008675 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 290339008676 metal binding site [ion binding]; metal-binding site 290339008677 dimer interface [polypeptide binding]; other site 290339008678 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 290339008679 active site 290339008680 DNA polymerase IV; Validated; Region: PRK02406 290339008681 DNA binding site [nucleotide binding] 290339008682 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 290339008683 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 290339008684 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 290339008685 putative active site [active] 290339008686 putative dimer interface [polypeptide binding]; other site 290339008687 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 290339008688 dimer interface [polypeptide binding]; other site 290339008689 active site 290339008690 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 290339008691 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 290339008692 active site 290339008693 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 290339008694 C-N hydrolase family amidase; Provisional; Region: PRK10438 290339008695 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 290339008696 putative active site [active] 290339008697 catalytic triad [active] 290339008698 dimer interface [polypeptide binding]; other site 290339008699 multimer interface [polypeptide binding]; other site 290339008700 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 290339008701 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 290339008702 active site 290339008703 catalytic site [active] 290339008704 substrate binding site [chemical binding]; other site 290339008705 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 290339008706 RNA/DNA hybrid binding site [nucleotide binding]; other site 290339008707 active site 290339008708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290339008709 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 290339008710 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 290339008711 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 290339008712 N-acetyl-D-glucosamine binding site [chemical binding]; other site 290339008713 catalytic residue [active] 290339008714 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 290339008715 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 290339008716 Methyltransferase domain; Region: Methyltransf_31; pfam13847 290339008717 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290339008718 S-adenosylmethionine binding site [chemical binding]; other site 290339008719 Flavivirus glycoprotein, central and dimerisation domains; Region: Flavi_glycoprot; pfam00869 290339008720 hypothetical protein; Provisional; Region: PRK05421 290339008721 putative catalytic site [active] 290339008722 putative phosphate binding site [ion binding]; other site 290339008723 putative metal binding site [ion binding]; other site 290339008724 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290339008725 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339008726 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 290339008727 putative effector binding pocket; other site 290339008728 dimerization interface [polypeptide binding]; other site 290339008729 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290339008730 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290339008731 active site 290339008732 catalytic tetrad [active] 290339008733 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 290339008734 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290339008735 active site 290339008736 motif I; other site 290339008737 motif II; other site 290339008738 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 290339008739 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 290339008740 Walker A/P-loop; other site 290339008741 ATP binding site [chemical binding]; other site 290339008742 Q-loop/lid; other site 290339008743 ABC transporter signature motif; other site 290339008744 Walker B; other site 290339008745 D-loop; other site 290339008746 H-loop/switch region; other site 290339008747 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 290339008748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339008749 dimer interface [polypeptide binding]; other site 290339008750 conserved gate region; other site 290339008751 ABC-ATPase subunit interface; other site 290339008752 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 290339008753 lipoprotein, YaeC family; Region: TIGR00363 290339008754 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 290339008755 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 290339008756 homodimer interaction site [polypeptide binding]; other site 290339008757 cofactor binding site; other site 290339008758 prolyl-tRNA synthetase; Provisional; Region: PRK09194 290339008759 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 290339008760 dimer interface [polypeptide binding]; other site 290339008761 motif 1; other site 290339008762 active site 290339008763 motif 2; other site 290339008764 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 290339008765 putative deacylase active site [active] 290339008766 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 290339008767 active site 290339008768 motif 3; other site 290339008769 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 290339008770 anticodon binding site; other site 290339008771 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 290339008772 NlpE N-terminal domain; Region: NlpE; pfam04170 290339008773 hypothetical protein; Provisional; Region: PRK09256 290339008774 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 290339008775 YaeQ protein; Region: YaeQ; pfam07152 290339008776 hypothetical protein; Provisional; Region: PRK04964 290339008777 Rho-binding antiterminator; Provisional; Region: PRK11625 290339008778 Cytochrome c553 [Energy production and conversion]; Region: COG2863 290339008779 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 290339008780 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 290339008781 Ligand Binding Site [chemical binding]; other site 290339008782 TilS substrate binding domain; Region: TilS; pfam09179 290339008783 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 290339008784 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 290339008785 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290339008786 putative metal binding site [ion binding]; other site 290339008787 lysine decarboxylase LdcC; Provisional; Region: PRK15399 290339008788 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 290339008789 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 290339008790 homodimer interface [polypeptide binding]; other site 290339008791 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339008792 catalytic residue [active] 290339008793 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 290339008794 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 290339008795 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 290339008796 putative sugar binding site [chemical binding]; other site 290339008797 catalytic residues [active] 290339008798 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 290339008799 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 290339008800 aromatic chitin/cellulose binding site residues [chemical binding]; other site 290339008801 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 290339008802 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 290339008803 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 290339008804 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 290339008805 putative active site [active] 290339008806 putative PHP Thumb interface [polypeptide binding]; other site 290339008807 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 290339008808 generic binding surface II; other site 290339008809 generic binding surface I; other site 290339008810 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 290339008811 RNA/DNA hybrid binding site [nucleotide binding]; other site 290339008812 active site 290339008813 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 290339008814 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 290339008815 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 290339008816 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 290339008817 active site 290339008818 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 290339008819 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 290339008820 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 290339008821 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 290339008822 trimer interface [polypeptide binding]; other site 290339008823 active site 290339008824 UDP-GlcNAc binding site [chemical binding]; other site 290339008825 lipid binding site [chemical binding]; lipid-binding site 290339008826 periplasmic chaperone; Provisional; Region: PRK10780 290339008827 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 290339008828 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 290339008829 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 290339008830 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 290339008831 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 290339008832 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 290339008833 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 290339008834 Surface antigen; Region: Bac_surface_Ag; pfam01103 290339008835 zinc metallopeptidase RseP; Provisional; Region: PRK10779 290339008836 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 290339008837 active site 290339008838 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 290339008839 protein binding site [polypeptide binding]; other site 290339008840 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 290339008841 protein binding site [polypeptide binding]; other site 290339008842 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 290339008843 putative substrate binding region [chemical binding]; other site 290339008844 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 290339008845 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 290339008846 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 290339008847 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 290339008848 catalytic residue [active] 290339008849 putative FPP diphosphate binding site; other site 290339008850 putative FPP binding hydrophobic cleft; other site 290339008851 dimer interface [polypeptide binding]; other site 290339008852 putative IPP diphosphate binding site; other site 290339008853 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 290339008854 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 290339008855 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 290339008856 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 290339008857 ribosome recycling factor; Reviewed; Region: frr; PRK00083 290339008858 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 290339008859 hinge region; other site 290339008860 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 290339008861 putative nucleotide binding site [chemical binding]; other site 290339008862 uridine monophosphate binding site [chemical binding]; other site 290339008863 homohexameric interface [polypeptide binding]; other site 290339008864 elongation factor Ts; Provisional; Region: tsf; PRK09377 290339008865 UBA/TS-N domain; Region: UBA; pfam00627 290339008866 Elongation factor TS; Region: EF_TS; pfam00889 290339008867 Elongation factor TS; Region: EF_TS; pfam00889 290339008868 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 290339008869 rRNA interaction site [nucleotide binding]; other site 290339008870 S8 interaction site; other site 290339008871 putative laminin-1 binding site; other site 290339008872 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 290339008873 active site 290339008874 PII uridylyl-transferase; Provisional; Region: PRK05007 290339008875 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 290339008876 metal binding triad; other site 290339008877 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 290339008878 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 290339008879 Zn2+ binding site [ion binding]; other site 290339008880 Mg2+ binding site [ion binding]; other site 290339008881 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 290339008882 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 290339008883 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 290339008884 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 290339008885 trimer interface [polypeptide binding]; other site 290339008886 active site 290339008887 substrate binding site [chemical binding]; other site 290339008888 CoA binding site [chemical binding]; other site 290339008889 hypothetical protein; Provisional; Region: PRK13677 290339008890 serine endoprotease; Provisional; Region: PRK10942 290339008891 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 290339008892 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 290339008893 protein binding site [polypeptide binding]; other site 290339008894 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 290339008895 protein binding site [polypeptide binding]; other site 290339008896 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 290339008897 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 290339008898 Zn2+ binding site [ion binding]; other site 290339008899 Mg2+ binding site [ion binding]; other site 290339008900 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 290339008901 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 290339008902 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 290339008903 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 290339008904 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 290339008905 cobalamin binding residues [chemical binding]; other site 290339008906 putative BtuC binding residues; other site 290339008907 dimer interface [polypeptide binding]; other site 290339008908 hypothetical protein; Provisional; Region: PRK10578 290339008909 UPF0126 domain; Region: UPF0126; pfam03458 290339008910 UPF0126 domain; Region: UPF0126; pfam03458 290339008911 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 290339008912 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 290339008913 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 290339008914 Cl- selectivity filter; other site 290339008915 Cl- binding residues [ion binding]; other site 290339008916 pore gating glutamate residue; other site 290339008917 dimer interface [polypeptide binding]; other site 290339008918 H+/Cl- coupling transport residue; other site 290339008919 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 290339008920 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 290339008921 inhibitor-cofactor binding pocket; inhibition site 290339008922 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339008923 catalytic residue [active] 290339008924 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 290339008925 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290339008926 ABC-ATPase subunit interface; other site 290339008927 dimer interface [polypeptide binding]; other site 290339008928 putative PBP binding regions; other site 290339008929 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290339008930 ABC-ATPase subunit interface; other site 290339008931 dimer interface [polypeptide binding]; other site 290339008932 putative PBP binding regions; other site 290339008933 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 290339008934 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 290339008935 siderophore binding site; other site 290339008936 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 290339008937 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 290339008938 Walker A/P-loop; other site 290339008939 ATP binding site [chemical binding]; other site 290339008940 Q-loop/lid; other site 290339008941 ABC transporter signature motif; other site 290339008942 Walker B; other site 290339008943 D-loop; other site 290339008944 H-loop/switch region; other site 290339008945 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 290339008946 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 290339008947 N-terminal plug; other site 290339008948 ligand-binding site [chemical binding]; other site 290339008949 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 290339008950 Transglycosylase; Region: Transgly; pfam00912 290339008951 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 290339008952 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 290339008953 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290339008954 ATP binding site [chemical binding]; other site 290339008955 putative Mg++ binding site [ion binding]; other site 290339008956 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290339008957 nucleotide binding region [chemical binding]; other site 290339008958 ATP-binding site [chemical binding]; other site 290339008959 Helicase associated domain (HA2); Region: HA2; pfam04408 290339008960 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 290339008961 2'-5' RNA ligase; Provisional; Region: PRK15124 290339008962 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 290339008963 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 290339008964 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 290339008965 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 290339008966 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 290339008967 active site 290339008968 HIGH motif; other site 290339008969 KMSKS motif; other site 290339008970 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 290339008971 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 290339008972 catalytic center binding site [active] 290339008973 ATP binding site [chemical binding]; other site 290339008974 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 290339008975 oligomerization interface [polypeptide binding]; other site 290339008976 active site 290339008977 metal binding site [ion binding]; metal-binding site 290339008978 pantoate--beta-alanine ligase; Region: panC; TIGR00018 290339008979 Pantoate-beta-alanine ligase; Region: PanC; cd00560 290339008980 active site 290339008981 ATP-binding site [chemical binding]; other site 290339008982 pantoate-binding site; other site 290339008983 HXXH motif; other site 290339008984 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 290339008985 tetramerization interface [polypeptide binding]; other site 290339008986 active site 290339008987 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 290339008988 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 290339008989 putative active site [active] 290339008990 putative metal binding site [ion binding]; other site 290339008991 inner membrane transport permease; Provisional; Region: PRK15066 290339008992 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 290339008993 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 290339008994 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 290339008995 Walker A/P-loop; other site 290339008996 ATP binding site [chemical binding]; other site 290339008997 Q-loop/lid; other site 290339008998 ABC transporter signature motif; other site 290339008999 Walker B; other site 290339009000 D-loop; other site 290339009001 H-loop/switch region; other site 290339009002 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 290339009003 active site clefts [active] 290339009004 zinc binding site [ion binding]; other site 290339009005 dimer interface [polypeptide binding]; other site 290339009006 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290339009007 active site 290339009008 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 290339009009 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 290339009010 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 290339009011 Trp docking motif [polypeptide binding]; other site 290339009012 putative active site [active] 290339009013 multicopper oxidase; Provisional; Region: PRK10965 290339009014 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 290339009015 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 290339009016 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 290339009017 spermidine synthase; Provisional; Region: PRK00811 290339009018 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290339009019 S-adenosylmethionine binding site [chemical binding]; other site 290339009020 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 290339009021 hypothetical protein; Provisional; Region: PRK05248 290339009022 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 290339009023 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 290339009024 substrate binding site [chemical binding]; other site 290339009025 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 290339009026 substrate binding site [chemical binding]; other site 290339009027 ligand binding site [chemical binding]; other site 290339009028 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 290339009029 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 290339009030 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 290339009031 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 290339009032 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 290339009033 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290339009034 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290339009035 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 290339009036 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 290339009037 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 290339009038 E3 interaction surface; other site 290339009039 lipoyl attachment site [posttranslational modification]; other site 290339009040 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 290339009041 E3 interaction surface; other site 290339009042 lipoyl attachment site [posttranslational modification]; other site 290339009043 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 290339009044 E3 interaction surface; other site 290339009045 lipoyl attachment site [posttranslational modification]; other site 290339009046 e3 binding domain; Region: E3_binding; pfam02817 290339009047 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 290339009048 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 290339009049 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 290339009050 dimer interface [polypeptide binding]; other site 290339009051 TPP-binding site [chemical binding]; other site 290339009052 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 290339009053 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290339009054 DNA-binding site [nucleotide binding]; DNA binding site 290339009055 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 290339009056 aromatic amino acid transporter; Provisional; Region: PRK10238 290339009057 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 290339009058 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339009059 putative substrate translocation pore; other site 290339009060 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 290339009061 active site 290339009062 regulatory protein AmpE; Provisional; Region: PRK10987 290339009063 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 290339009064 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 290339009065 amidase catalytic site [active] 290339009066 substrate binding site [chemical binding]; other site 290339009067 Zn binding residues [ion binding]; other site 290339009068 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 290339009069 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 290339009070 dimerization interface [polypeptide binding]; other site 290339009071 active site 290339009072 putative major pilin subunit; Provisional; Region: PRK10574 290339009073 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 290339009074 Pilin (bacterial filament); Region: Pilin; pfam00114 290339009075 hypothetical protein; Provisional; Region: PRK10436 290339009076 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 290339009077 Walker A motif; other site 290339009078 ATP binding site [chemical binding]; other site 290339009079 Walker B motif; other site 290339009080 type IV pilin biogenesis protein; Provisional; Region: PRK10573 290339009081 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 290339009082 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 290339009083 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 290339009084 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 290339009085 active site 290339009086 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 290339009087 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 290339009088 CoA-binding site [chemical binding]; other site 290339009089 ATP-binding [chemical binding]; other site 290339009090 hypothetical protein; Provisional; Region: PRK05287 290339009091 DNA gyrase inhibitor; Reviewed; Region: PRK00418 290339009092 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 290339009093 active site 290339009094 8-oxo-dGMP binding site [chemical binding]; other site 290339009095 nudix motif; other site 290339009096 metal binding site [ion binding]; metal-binding site 290339009097 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 290339009098 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 290339009099 SEC-C motif; Region: SEC-C; pfam02810 290339009100 SecA regulator SecM; Provisional; Region: PRK02943 290339009101 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 290339009102 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 290339009103 cell division protein FtsZ; Validated; Region: PRK09330 290339009104 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 290339009105 nucleotide binding site [chemical binding]; other site 290339009106 SulA interaction site; other site 290339009107 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 290339009108 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 290339009109 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 290339009110 Cell division protein FtsA; Region: FtsA; pfam14450 290339009111 cell division protein FtsQ; Provisional; Region: PRK10775 290339009112 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 290339009113 Cell division protein FtsQ; Region: FtsQ; pfam03799 290339009114 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 290339009115 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 290339009116 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 290339009117 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 290339009118 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 290339009119 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 290339009120 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 290339009121 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 290339009122 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 290339009123 active site 290339009124 homodimer interface [polypeptide binding]; other site 290339009125 cell division protein FtsW; Provisional; Region: PRK10774 290339009126 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 290339009127 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 290339009128 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 290339009129 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 290339009130 Mg++ binding site [ion binding]; other site 290339009131 putative catalytic motif [active] 290339009132 putative substrate binding site [chemical binding]; other site 290339009133 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 290339009134 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 290339009135 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 290339009136 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 290339009137 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 290339009138 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 290339009139 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 290339009140 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 290339009141 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 290339009142 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 290339009143 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 290339009144 cell division protein FtsL; Provisional; Region: PRK10772 290339009145 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 290339009146 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 290339009147 cell division protein MraZ; Reviewed; Region: PRK00326 290339009148 MraZ protein; Region: MraZ; pfam02381 290339009149 MraZ protein; Region: MraZ; pfam02381 290339009150 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 290339009151 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290339009152 DNA binding site [nucleotide binding] 290339009153 domain linker motif; other site 290339009154 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 290339009155 dimerization interface [polypeptide binding]; other site 290339009156 ligand binding site [chemical binding]; other site 290339009157 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 290339009158 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 290339009159 putative valine binding site [chemical binding]; other site 290339009160 dimer interface [polypeptide binding]; other site 290339009161 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 290339009162 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 290339009163 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 290339009164 PYR/PP interface [polypeptide binding]; other site 290339009165 dimer interface [polypeptide binding]; other site 290339009166 TPP binding site [chemical binding]; other site 290339009167 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 290339009168 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 290339009169 TPP-binding site [chemical binding]; other site 290339009170 dimer interface [polypeptide binding]; other site 290339009171 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 290339009172 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339009173 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 290339009174 putative substrate binding pocket [chemical binding]; other site 290339009175 putative dimerization interface [polypeptide binding]; other site 290339009176 leucine operon leader 290339009177 2-isopropylmalate synthase; Validated; Region: PRK00915 290339009178 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 290339009179 active site 290339009180 catalytic residues [active] 290339009181 metal binding site [ion binding]; metal-binding site 290339009182 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 290339009183 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 290339009184 tartrate dehydrogenase; Region: TTC; TIGR02089 290339009185 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 290339009186 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 290339009187 substrate binding site [chemical binding]; other site 290339009188 ligand binding site [chemical binding]; other site 290339009189 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 290339009190 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 290339009191 substrate binding site [chemical binding]; other site 290339009192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339009193 sugar efflux transporter; Region: 2A0120; TIGR00899 290339009194 putative substrate translocation pore; other site 290339009195 transcriptional regulator SgrR; Provisional; Region: PRK13626 290339009196 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 290339009197 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 290339009198 TPP riboswitch (THI element) 290339009199 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 290339009200 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 290339009201 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 290339009202 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339009203 dimer interface [polypeptide binding]; other site 290339009204 conserved gate region; other site 290339009205 putative PBP binding loops; other site 290339009206 ABC-ATPase subunit interface; other site 290339009207 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339009208 dimer interface [polypeptide binding]; other site 290339009209 conserved gate region; other site 290339009210 putative PBP binding loops; other site 290339009211 ABC-ATPase subunit interface; other site 290339009212 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 290339009213 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 290339009214 Walker A/P-loop; other site 290339009215 ATP binding site [chemical binding]; other site 290339009216 Q-loop/lid; other site 290339009217 ABC transporter signature motif; other site 290339009218 Walker B; other site 290339009219 D-loop; other site 290339009220 H-loop/switch region; other site 290339009221 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 290339009222 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 290339009223 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 290339009224 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 290339009225 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290339009226 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290339009227 ribulokinase; Provisional; Region: PRK04123 290339009228 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 290339009229 N- and C-terminal domain interface [polypeptide binding]; other site 290339009230 active site 290339009231 MgATP binding site [chemical binding]; other site 290339009232 catalytic site [active] 290339009233 metal binding site [ion binding]; metal-binding site 290339009234 carbohydrate binding site [chemical binding]; other site 290339009235 homodimer interface [polypeptide binding]; other site 290339009236 L-arabinose isomerase; Provisional; Region: PRK02929 290339009237 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 290339009238 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 290339009239 trimer interface [polypeptide binding]; other site 290339009240 putative substrate binding site [chemical binding]; other site 290339009241 putative metal binding site [ion binding]; other site 290339009242 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 290339009243 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 290339009244 intersubunit interface [polypeptide binding]; other site 290339009245 active site 290339009246 Zn2+ binding site [ion binding]; other site 290339009247 DNA polymerase II; Reviewed; Region: PRK05762 290339009248 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 290339009249 active site 290339009250 catalytic site [active] 290339009251 substrate binding site [chemical binding]; other site 290339009252 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 290339009253 active site 290339009254 metal-binding site 290339009255 ATP-dependent helicase HepA; Validated; Region: PRK04914 290339009256 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290339009257 ATP binding site [chemical binding]; other site 290339009258 putative Mg++ binding site [ion binding]; other site 290339009259 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290339009260 nucleotide binding region [chemical binding]; other site 290339009261 ATP-binding site [chemical binding]; other site 290339009262 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 290339009263 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 290339009264 active site 290339009265 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 290339009266 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 290339009267 putative metal binding site [ion binding]; other site 290339009268 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 290339009269 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 290339009270 OstA-like protein; Region: OstA; pfam03968 290339009271 Organic solvent tolerance protein; Region: OstA_C; pfam04453 290339009272 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 290339009273 SurA N-terminal domain; Region: SurA_N; pfam09312 290339009274 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 290339009275 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 290339009276 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 290339009277 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 290339009278 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 290339009279 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 290339009280 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 290339009281 active site 290339009282 metal binding site [ion binding]; metal-binding site 290339009283 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 290339009284 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 290339009285 folate binding site [chemical binding]; other site 290339009286 NADP+ binding site [chemical binding]; other site 290339009287 LysE type translocator; Region: LysE; cl00565 290339009288 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 290339009289 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 290339009290 TrkA-N domain; Region: TrkA_N; pfam02254 290339009291 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 290339009292 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 290339009293 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 290339009294 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 290339009295 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 290339009296 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 290339009297 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 290339009298 ATP-grasp domain; Region: ATP-grasp_4; cl17255 290339009299 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 290339009300 IMP binding site; other site 290339009301 dimer interface [polypeptide binding]; other site 290339009302 interdomain contacts; other site 290339009303 partial ornithine binding site; other site 290339009304 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 290339009305 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 290339009306 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 290339009307 catalytic site [active] 290339009308 subunit interface [polypeptide binding]; other site 290339009309 dihydrodipicolinate reductase; Provisional; Region: PRK00048 290339009310 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 290339009311 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 290339009312 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 290339009313 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 290339009314 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 290339009315 putative active site [active] 290339009316 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 290339009317 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 290339009318 active site 290339009319 phosphorylation site [posttranslational modification] 290339009320 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 290339009321 active site 290339009322 P-loop; other site 290339009323 phosphorylation site [posttranslational modification] 290339009324 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 290339009325 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 290339009326 alpha-mannosidase; Provisional; Region: PRK09819 290339009327 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 290339009328 active site 290339009329 metal binding site [ion binding]; metal-binding site 290339009330 catalytic site [active] 290339009331 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 290339009332 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 290339009333 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 290339009334 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 290339009335 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 290339009336 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290339009337 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339009338 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 290339009339 putative effector binding pocket; other site 290339009340 dimerization interface [polypeptide binding]; other site 290339009341 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 290339009342 active site 290339009343 tetramer interface [polypeptide binding]; other site 290339009344 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 290339009345 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 290339009346 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 290339009347 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 290339009348 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 290339009349 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 290339009350 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290339009351 active site 290339009352 HIGH motif; other site 290339009353 nucleotide binding site [chemical binding]; other site 290339009354 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 290339009355 active site 290339009356 KMSKS motif; other site 290339009357 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 290339009358 tRNA binding surface [nucleotide binding]; other site 290339009359 anticodon binding site; other site 290339009360 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 290339009361 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 290339009362 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 290339009363 active site 290339009364 Riboflavin kinase; Region: Flavokinase; smart00904 290339009365 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 290339009366 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 290339009367 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339009368 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 290339009369 putative dimerization interface [polypeptide binding]; other site 290339009370 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 290339009371 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 290339009372 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 290339009373 active site 290339009374 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 290339009375 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 290339009376 aromatic chitin/cellulose binding site residues [chemical binding]; other site 290339009377 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 290339009378 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 290339009379 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 290339009380 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 290339009381 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290339009382 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339009383 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290339009384 chaperone protein DnaJ; Provisional; Region: PRK10767 290339009385 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 290339009386 HSP70 interaction site [polypeptide binding]; other site 290339009387 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 290339009388 substrate binding site [polypeptide binding]; other site 290339009389 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 290339009390 Zn binding sites [ion binding]; other site 290339009391 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 290339009392 dimer interface [polypeptide binding]; other site 290339009393 NAD-specific glutamate dehydrogenase; Region: NAD-GH; pfam10712 290339009394 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 290339009395 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 290339009396 nucleotide binding site [chemical binding]; other site 290339009397 hypothetical protein; Provisional; Region: PRK10659 290339009398 metabolite-proton symporter; Region: 2A0106; TIGR00883 290339009399 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339009400 putative substrate translocation pore; other site 290339009401 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 290339009402 MPT binding site; other site 290339009403 trimer interface [polypeptide binding]; other site 290339009404 transaldolase-like protein; Provisional; Region: PTZ00411 290339009405 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 290339009406 active site 290339009407 dimer interface [polypeptide binding]; other site 290339009408 catalytic residue [active] 290339009409 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 290339009410 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 290339009411 hypothetical protein; Validated; Region: PRK02101 290339009412 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 290339009413 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 290339009414 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339009415 catalytic residue [active] 290339009416 homoserine kinase; Provisional; Region: PRK01212 290339009417 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 290339009418 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 290339009419 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 290339009420 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 290339009421 putative catalytic residues [active] 290339009422 putative nucleotide binding site [chemical binding]; other site 290339009423 putative aspartate binding site [chemical binding]; other site 290339009424 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 290339009425 dimer interface [polypeptide binding]; other site 290339009426 putative threonine allosteric regulatory site; other site 290339009427 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 290339009428 putative threonine allosteric regulatory site; other site 290339009429 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 290339009430 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 290339009431 threonine operon leader 290339009432 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 290339009433 putative RNA methyltransferase; Provisional; Region: PRK10433 290339009434 two-component response regulator; Provisional; Region: PRK11173 290339009435 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290339009436 active site 290339009437 phosphorylation site [posttranslational modification] 290339009438 intermolecular recognition site; other site 290339009439 dimerization interface [polypeptide binding]; other site 290339009440 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290339009441 DNA binding site [nucleotide binding] 290339009442 Inner membrane protein CreD; Region: CreD; pfam06123 290339009443 sensory histidine kinase CreC; Provisional; Region: PRK11100 290339009444 HAMP domain; Region: HAMP; pfam00672 290339009445 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290339009446 dimer interface [polypeptide binding]; other site 290339009447 phosphorylation site [posttranslational modification] 290339009448 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290339009449 ATP binding site [chemical binding]; other site 290339009450 Mg2+ binding site [ion binding]; other site 290339009451 G-X-G motif; other site 290339009452 DNA-binding response regulator CreB; Provisional; Region: PRK11083 290339009453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290339009454 active site 290339009455 phosphorylation site [posttranslational modification] 290339009456 intermolecular recognition site; other site 290339009457 dimerization interface [polypeptide binding]; other site 290339009458 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290339009459 DNA binding site [nucleotide binding] 290339009460 hypothetical protein; Provisional; Region: PRK10756 290339009461 CreA protein; Region: CreA; pfam05981 290339009462 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 290339009463 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290339009464 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 290339009465 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290339009466 catalytic core [active] 290339009467 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 290339009468 Trp operon repressor; Provisional; Region: PRK01381 290339009469 lytic murein transglycosylase; Provisional; Region: PRK11619 290339009470 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 290339009471 N-acetyl-D-glucosamine binding site [chemical binding]; other site 290339009472 catalytic residue [active] 290339009473 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 290339009474 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290339009475 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290339009476 ABC transporter; Region: ABC_tran_2; pfam12848 290339009477 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290339009478 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 290339009479 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 290339009480 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 290339009481 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 290339009482 Low molecular weight phosphatase family; Region: LMWPc; cl00105 290339009483 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 290339009484 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 290339009485 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 290339009486 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 290339009487 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 290339009488 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 290339009489 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 290339009490 active site 290339009491 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 290339009492 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 290339009493 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 290339009494 Walker A/P-loop; other site 290339009495 ATP binding site [chemical binding]; other site 290339009496 Q-loop/lid; other site 290339009497 ABC transporter signature motif; other site 290339009498 Walker B; other site 290339009499 D-loop; other site 290339009500 H-loop/switch region; other site 290339009501 ABC-2 type transporter; Region: ABC2_membrane; cl17235 290339009502 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290339009503 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339009504 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 290339009505 putative effector binding pocket; other site 290339009506 dimerization interface [polypeptide binding]; other site 290339009507 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 290339009508 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 290339009509 putative NAD(P) binding site [chemical binding]; other site 290339009510 dimer interface [polypeptide binding]; other site 290339009511 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290339009512 non-specific DNA binding site [nucleotide binding]; other site 290339009513 salt bridge; other site 290339009514 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 290339009515 sequence-specific DNA binding site [nucleotide binding]; other site 290339009516 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 290339009517 active site 290339009518 (T/H)XGH motif; other site 290339009519 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 290339009520 DNA repair protein RadA; Region: sms; TIGR00416 290339009521 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 290339009522 Walker A motif/ATP binding site; other site 290339009523 ATP binding site [chemical binding]; other site 290339009524 Walker B motif; other site 290339009525 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 290339009526 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 290339009527 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290339009528 motif II; other site 290339009529 hypothetical protein; Provisional; Region: PRK11246 290339009530 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 290339009531 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 290339009532 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 290339009533 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 290339009534 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 290339009535 phosphopentomutase; Provisional; Region: PRK05362 290339009536 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 290339009537 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 290339009538 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 290339009539 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 290339009540 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 290339009541 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 290339009542 intersubunit interface [polypeptide binding]; other site 290339009543 active site 290339009544 catalytic residue [active] 290339009545 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 290339009546 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 290339009547 Nucleoside recognition; Region: Gate; pfam07670 290339009548 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 290339009549 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 290339009550 active site 290339009551 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 290339009552 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 290339009553 active site 290339009554 nucleophile elbow; other site 290339009555 periplasmic protein; Provisional; Region: PRK10568 290339009556 BON domain; Region: BON; pfam04972 290339009557 BON domain; Region: BON; pfam04972 290339009558 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 290339009559 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 290339009560 G1 box; other site 290339009561 putative GEF interaction site [polypeptide binding]; other site 290339009562 GTP/Mg2+ binding site [chemical binding]; other site 290339009563 Switch I region; other site 290339009564 G2 box; other site 290339009565 G3 box; other site 290339009566 Switch II region; other site 290339009567 G4 box; other site 290339009568 G5 box; other site 290339009569 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 290339009570 dUMP phosphatase; Provisional; Region: PRK09449 290339009571 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290339009572 motif II; other site 290339009573 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 290339009574 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 290339009575 Coenzyme A binding pocket [chemical binding]; other site 290339009576 DNA polymerase III psi subunit; Region: DNA_III_psi; pfam03603 290339009577 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 290339009578 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 290339009579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290339009580 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 290339009581 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 290339009582 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290339009583 metal binding site [ion binding]; metal-binding site 290339009584 active site 290339009585 I-site; other site 290339009586 Uncharacterized Fe-S protein [General function prediction only]; Region: FhuF; COG4114 290339009587 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 290339009588 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 290339009589 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 290339009590 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 290339009591 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 290339009592 putative deacylase active site [active] 290339009593 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 290339009594 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290339009595 DNA binding residues [nucleotide binding] 290339009596 dimerization interface [polypeptide binding]; other site 290339009597 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290339009598 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290339009599 DNA binding residues [nucleotide binding] 290339009600 dimerization interface [polypeptide binding]; other site 290339009601 Uncharacterized conserved protein [Function unknown]; Region: COG2966 290339009602 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 290339009603 hypothetical protein; Provisional; Region: PRK09917 290339009604 Transcriptional regulators [Transcription]; Region: MarR; COG1846 290339009605 MarR family; Region: MarR; pfam01047 290339009606 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 290339009607 primosomal protein DnaI; Provisional; Region: PRK02854 290339009608 DNA replication protein DnaC; Validated; Region: PRK07952 290339009609 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290339009610 Walker A motif; other site 290339009611 ATP binding site [chemical binding]; other site 290339009612 Walker B motif; other site 290339009613 phosphoglycerol transferase I; Provisional; Region: PRK03776 290339009614 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 290339009615 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 290339009616 GAF domain; Region: GAF; pfam01590 290339009617 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 290339009618 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290339009619 metal binding site [ion binding]; metal-binding site 290339009620 active site 290339009621 I-site; other site 290339009622 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290339009623 dimerization interface [polypeptide binding]; other site 290339009624 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 290339009625 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290339009626 metal binding site [ion binding]; metal-binding site 290339009627 active site 290339009628 I-site; other site 290339009629 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 290339009630 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 290339009631 dimer interface [polypeptide binding]; other site 290339009632 ligand binding site [chemical binding]; other site 290339009633 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290339009634 dimerization interface [polypeptide binding]; other site 290339009635 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 290339009636 dimer interface [polypeptide binding]; other site 290339009637 putative CheW interface [polypeptide binding]; other site 290339009638 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 290339009639 catalytic triad [active] 290339009640 putative active site [active] 290339009641 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 290339009642 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 290339009643 Autotransporter beta-domain; Region: Autotransporter; pfam03797 290339009644 cytosine deaminase; Provisional; Region: PRK09230 290339009645 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 290339009646 active site 290339009647 cytosine permease; Provisional; Region: codB; PRK11017 290339009648 Na binding site [ion binding]; other site 290339009649 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 290339009650 beta-galactosidase; Region: BGL; TIGR03356 290339009651 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 290339009652 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 290339009653 active site turn [active] 290339009654 phosphorylation site [posttranslational modification] 290339009655 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 290339009656 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290339009657 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290339009658 DNA binding site [nucleotide binding] 290339009659 domain linker motif; other site 290339009660 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 290339009661 dimerization interface (closed form) [polypeptide binding]; other site 290339009662 ligand binding site [chemical binding]; other site 290339009663 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 290339009664 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 290339009665 HlyD family secretion protein; Region: HlyD_3; pfam13437 290339009666 transcriptional regulator SlyA; Provisional; Region: PRK03573 290339009667 MarR family; Region: MarR_2; cl17246 290339009668 lac repressor; Reviewed; Region: lacI; PRK09526 290339009669 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290339009670 DNA binding site [nucleotide binding] 290339009671 domain linker motif; other site 290339009672 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 290339009673 ligand binding site [chemical binding]; other site 290339009674 dimerization interface (open form) [polypeptide binding]; other site 290339009675 dimerization interface (closed form) [polypeptide binding]; other site 290339009676 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 290339009677 trimer interface; other site 290339009678 sugar binding site [chemical binding]; other site 290339009679 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 290339009680 active site turn [active] 290339009681 phosphorylation site [posttranslational modification] 290339009682 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 290339009683 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 290339009684 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 290339009685 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 290339009686 Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism]; Region: COG3867 290339009687 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290339009688 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339009689 dimer interface [polypeptide binding]; other site 290339009690 conserved gate region; other site 290339009691 putative PBP binding loops; other site 290339009692 ABC-ATPase subunit interface; other site 290339009693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339009694 dimer interface [polypeptide binding]; other site 290339009695 conserved gate region; other site 290339009696 ABC-ATPase subunit interface; other site 290339009697 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 290339009698 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290339009699 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 290339009700 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 290339009701 Walker A/P-loop; other site 290339009702 ATP binding site [chemical binding]; other site 290339009703 Q-loop/lid; other site 290339009704 ABC transporter signature motif; other site 290339009705 Walker B; other site 290339009706 D-loop; other site 290339009707 H-loop/switch region; other site 290339009708 TOBE domain; Region: TOBE; cl01440 290339009709 TOBE domain; Region: TOBE_2; pfam08402 290339009710 endoribonuclease SymE; Provisional; Region: PRK13605 290339009711 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 290339009712 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 290339009713 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290339009714 DNA-binding site [nucleotide binding]; DNA binding site 290339009715 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290339009716 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339009717 homodimer interface [polypeptide binding]; other site 290339009718 catalytic residue [active] 290339009719 Protein of unknown function (DUF445); Region: DUF445; pfam04286 290339009720 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 290339009721 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 290339009722 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 290339009723 active site 290339009724 Methyltransferase domain; Region: Methyltransf_23; pfam13489 290339009725 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290339009726 S-adenosylmethionine binding site [chemical binding]; other site 290339009727 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 290339009728 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 290339009729 putative NAD(P) binding site [chemical binding]; other site 290339009730 putative substrate binding site [chemical binding]; other site 290339009731 catalytic Zn binding site [ion binding]; other site 290339009732 structural Zn binding site [ion binding]; other site 290339009733 dimer interface [polypeptide binding]; other site 290339009734 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 290339009735 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 290339009736 Zn binding sites [ion binding]; other site 290339009737 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 290339009738 DAK2 domain; Region: Dak2; pfam02734 290339009739 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 290339009740 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 290339009741 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 290339009742 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 290339009743 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 290339009744 multifunctional aminopeptidase A; Provisional; Region: PRK00913 290339009745 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 290339009746 interface (dimer of trimers) [polypeptide binding]; other site 290339009747 Substrate-binding/catalytic site; other site 290339009748 Zn-binding sites [ion binding]; other site 290339009749 DNA polymerase III subunit chi; Validated; Region: PRK05728 290339009750 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 290339009751 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 290339009752 HIGH motif; other site 290339009753 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 290339009754 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 290339009755 active site 290339009756 KMSKS motif; other site 290339009757 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 290339009758 tRNA binding surface [nucleotide binding]; other site 290339009759 anticodon binding site; other site 290339009760 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 290339009761 Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987 290339009762 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 290339009763 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290339009764 Coenzyme A binding pocket [chemical binding]; other site 290339009765 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 290339009766 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 290339009767 active site 290339009768 dinuclear metal binding site [ion binding]; other site 290339009769 dimerization interface [polypeptide binding]; other site 290339009770 RNase E inhibitor protein; Provisional; Region: PRK11191 290339009771 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 290339009772 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 290339009773 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 290339009774 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 290339009775 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 290339009776 active site 290339009777 Methyltransferase domain; Region: Methyltransf_23; pfam13489 290339009778 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290339009779 S-adenosylmethionine binding site [chemical binding]; other site 290339009780 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 290339009781 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 290339009782 putative NAD(P) binding site [chemical binding]; other site 290339009783 putative substrate binding site [chemical binding]; other site 290339009784 catalytic Zn binding site [ion binding]; other site 290339009785 structural Zn binding site [ion binding]; other site 290339009786 dimer interface [polypeptide binding]; other site 290339009787 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 290339009788 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 290339009789 Zn binding sites [ion binding]; other site 290339009790 dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361 290339009791 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 290339009792 DAK2 domain; Region: Dak2; pfam02734 290339009793 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 290339009794 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 290339009795 multifunctional aminopeptidase A; Provisional; Region: PRK00913 290339009796 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 290339009797 interface (dimer of trimers) [polypeptide binding]; other site 290339009798 Substrate-binding/catalytic site; other site 290339009799 Zn-binding sites [ion binding]; other site 290339009800 DNA polymerase III subunit chi; Validated; Region: PRK05728 290339009801 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 290339009802 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 290339009803 HIGH motif; other site 290339009804 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 290339009805 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 290339009806 active site 290339009807 KMSKS motif; other site 290339009808 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 290339009809 tRNA binding surface [nucleotide binding]; other site 290339009810 anticodon binding site; other site 290339009811 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 290339009812 Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987 290339009813 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 290339009814 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290339009815 Coenzyme A binding pocket [chemical binding]; other site 290339009816 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 290339009817 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 290339009818 active site 290339009819 dinuclear metal binding site [ion binding]; other site 290339009820 dimerization interface [polypeptide binding]; other site 290339009821 RNase E inhibitor protein; Provisional; Region: PRK11191 290339009822 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 290339009823 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 290339009824 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 290339009825 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 290339009826 arginine deiminase; Provisional; Region: PRK01388 290339009827 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 290339009828 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 290339009829 putative substrate binding site [chemical binding]; other site 290339009830 nucleotide binding site [chemical binding]; other site 290339009831 nucleotide binding site [chemical binding]; other site 290339009832 homodimer interface [polypeptide binding]; other site 290339009833 ornithine carbamoyltransferase; Validated; Region: PRK02102 290339009834 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 290339009835 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 290339009836 Predicted membrane protein [Function unknown]; Region: COG1288 290339009837 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 290339009838 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 290339009839 Arginine repressor [Transcription]; Region: ArgR; COG1438 290339009840 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 290339009841 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 290339009842 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 290339009843 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 290339009844 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 290339009845 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 290339009846 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 290339009847 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 290339009848 homotrimer interaction site [polypeptide binding]; other site 290339009849 putative active site [active] 290339009850 hypothetical protein; Provisional; Region: PRK01254 290339009851 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 290339009852 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 290339009853 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 290339009854 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 290339009855 FAD binding pocket [chemical binding]; other site 290339009856 FAD binding motif [chemical binding]; other site 290339009857 phosphate binding motif [ion binding]; other site 290339009858 NAD binding pocket [chemical binding]; other site 290339009859 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 290339009860 Predicted transcriptional regulators [Transcription]; Region: COG1695 290339009861 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 290339009862 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 290339009863 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290339009864 dimerization interface [polypeptide binding]; other site 290339009865 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 290339009866 dimer interface [polypeptide binding]; other site 290339009867 putative CheW interface [polypeptide binding]; other site 290339009868 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290339009869 PAS domain; Region: PAS_9; pfam13426 290339009870 putative active site [active] 290339009871 heme pocket [chemical binding]; other site 290339009872 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 290339009873 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 290339009874 dimer interface [polypeptide binding]; other site 290339009875 putative CheW interface [polypeptide binding]; other site 290339009876 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 290339009877 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290339009878 metal binding site [ion binding]; metal-binding site 290339009879 active site 290339009880 I-site; other site 290339009881 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 290339009882 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 290339009883 inhibitor-cofactor binding pocket; inhibition site 290339009884 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339009885 catalytic residue [active] 290339009886 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 290339009887 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 290339009888 active site 290339009889 FMN binding site [chemical binding]; other site 290339009890 2,4-decadienoyl-CoA binding site; other site 290339009891 catalytic residue [active] 290339009892 4Fe-4S cluster binding site [ion binding]; other site 290339009893 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 290339009894 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290339009895 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 290339009896 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290339009897 S-adenosylmethionine binding site [chemical binding]; other site 290339009898 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 290339009899 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 290339009900 putative active site [active] 290339009901 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290339009902 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290339009903 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 290339009904 serine/threonine transporter SstT; Provisional; Region: PRK13628 290339009905 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 290339009906 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 290339009907 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 290339009908 galactarate dehydratase; Region: galactar-dH20; TIGR03248 290339009909 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 290339009910 Glucuronate isomerase; Region: UxaC; pfam02614 290339009911 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 290339009912 D-galactonate transporter; Region: 2A0114; TIGR00893 290339009913 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339009914 putative substrate translocation pore; other site 290339009915 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 290339009916 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290339009917 DNA-binding site [nucleotide binding]; DNA binding site 290339009918 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 290339009919 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 290339009920 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 290339009921 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 290339009922 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 290339009923 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 290339009924 Predicted membrane protein [Function unknown]; Region: COG5393 290339009925 YqjK-like protein; Region: YqjK; pfam13997 290339009926 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 290339009927 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 290339009928 hypothetical protein; Provisional; Region: PRK15301 290339009929 putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304 290339009930 PapC N-terminal domain; Region: PapC_N; pfam13954 290339009931 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 290339009932 PapC C-terminal domain; Region: PapC_C; pfam13953 290339009933 putative fimbrial chaperone protein; Provisional; Region: PRK09918 290339009934 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 290339009935 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 290339009936 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 290339009937 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 290339009938 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 290339009939 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 290339009940 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 290339009941 Predicted membrane protein [Function unknown]; Region: COG2259 290339009942 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 290339009943 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 290339009944 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 290339009945 putative dimer interface [polypeptide binding]; other site 290339009946 N-terminal domain interface [polypeptide binding]; other site 290339009947 putative substrate binding pocket (H-site) [chemical binding]; other site 290339009948 Predicted membrane protein [Function unknown]; Region: COG3152 290339009949 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290339009950 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 290339009951 putative substrate binding site [chemical binding]; other site 290339009952 putative ATP binding site [chemical binding]; other site 290339009953 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 290339009954 trimer interface; other site 290339009955 sugar binding site [chemical binding]; other site 290339009956 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 290339009957 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 290339009958 active site turn [active] 290339009959 phosphorylation site [posttranslational modification] 290339009960 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 290339009961 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 290339009962 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 290339009963 substrate binding [chemical binding]; other site 290339009964 active site 290339009965 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 290339009966 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 290339009967 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290339009968 DNA binding site [nucleotide binding] 290339009969 domain linker motif; other site 290339009970 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 290339009971 dimerization interface [polypeptide binding]; other site 290339009972 ligand binding site [chemical binding]; other site 290339009973 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339009974 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 290339009975 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290339009976 dimerization interface [polypeptide binding]; other site 290339009977 Pirin-related protein [General function prediction only]; Region: COG1741 290339009978 Pirin; Region: Pirin; pfam02678 290339009979 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 290339009980 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 290339009981 putative SAM binding site [chemical binding]; other site 290339009982 putative homodimer interface [polypeptide binding]; other site 290339009983 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 290339009984 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 290339009985 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 290339009986 putative ligand binding site [chemical binding]; other site 290339009987 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 290339009988 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 290339009989 dimer interface [polypeptide binding]; other site 290339009990 active site 290339009991 outer membrane lipoprotein; Provisional; Region: PRK11023 290339009992 BON domain; Region: BON; pfam04972 290339009993 BON domain; Region: BON; pfam04972 290339009994 Predicted permease; Region: DUF318; pfam03773 290339009995 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 290339009996 NADH(P)-binding; Region: NAD_binding_10; pfam13460 290339009997 NAD binding site [chemical binding]; other site 290339009998 active site 290339009999 intracellular protease, PfpI family; Region: PfpI; TIGR01382 290339010000 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 290339010001 proposed catalytic triad [active] 290339010002 conserved cys residue [active] 290339010003 hypothetical protein; Provisional; Region: PRK03467 290339010004 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 290339010005 GIY-YIG motif/motif A; other site 290339010006 putative active site [active] 290339010007 putative metal binding site [ion binding]; other site 290339010008 putative acetyltransferase; Provisional; Region: PRK03624 290339010009 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290339010010 Coenzyme A binding pocket [chemical binding]; other site 290339010011 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 290339010012 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 290339010013 Peptidase family U32; Region: Peptidase_U32; pfam01136 290339010014 putative protease; Provisional; Region: PRK15447 290339010015 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 290339010016 hypothetical protein; Provisional; Region: PRK10508 290339010017 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 290339010018 tryptophan permease; Provisional; Region: PRK10483 290339010019 aromatic amino acid transport protein; Region: araaP; TIGR00837 290339010020 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 290339010021 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 290339010022 ATP binding site [chemical binding]; other site 290339010023 Mg++ binding site [ion binding]; other site 290339010024 motif III; other site 290339010025 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290339010026 nucleotide binding region [chemical binding]; other site 290339010027 ATP-binding site [chemical binding]; other site 290339010028 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 290339010029 putative RNA binding site [nucleotide binding]; other site 290339010030 lipoprotein NlpI; Provisional; Region: PRK11189 290339010031 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290339010032 binding surface 290339010033 TPR motif; other site 290339010034 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 290339010035 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 290339010036 trimer interface [polypeptide binding]; other site 290339010037 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 290339010038 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 290339010039 RNase E interface [polypeptide binding]; other site 290339010040 trimer interface [polypeptide binding]; other site 290339010041 active site 290339010042 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 290339010043 putative nucleic acid binding region [nucleotide binding]; other site 290339010044 G-X-X-G motif; other site 290339010045 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 290339010046 RNA binding site [nucleotide binding]; other site 290339010047 domain interface; other site 290339010048 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 290339010049 16S/18S rRNA binding site [nucleotide binding]; other site 290339010050 S13e-L30e interaction site [polypeptide binding]; other site 290339010051 25S rRNA binding site [nucleotide binding]; other site 290339010052 ribosomal s15 leader 290339010053 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 290339010054 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 290339010055 RNA binding site [nucleotide binding]; other site 290339010056 active site 290339010057 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 290339010058 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 290339010059 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 290339010060 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 290339010061 translation initiation factor IF-2; Region: IF-2; TIGR00487 290339010062 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 290339010063 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 290339010064 G1 box; other site 290339010065 putative GEF interaction site [polypeptide binding]; other site 290339010066 GTP/Mg2+ binding site [chemical binding]; other site 290339010067 Switch I region; other site 290339010068 G2 box; other site 290339010069 G3 box; other site 290339010070 Switch II region; other site 290339010071 G4 box; other site 290339010072 G5 box; other site 290339010073 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 290339010074 Translation-initiation factor 2; Region: IF-2; pfam11987 290339010075 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 290339010076 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 290339010077 NusA N-terminal domain; Region: NusA_N; pfam08529 290339010078 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 290339010079 RNA binding site [nucleotide binding]; other site 290339010080 homodimer interface [polypeptide binding]; other site 290339010081 NusA-like KH domain; Region: KH_5; pfam13184 290339010082 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 290339010083 G-X-X-G motif; other site 290339010084 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 290339010085 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 290339010086 ribosome maturation protein RimP; Reviewed; Region: PRK00092 290339010087 Sm and related proteins; Region: Sm_like; cl00259 290339010088 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 290339010089 putative oligomer interface [polypeptide binding]; other site 290339010090 putative RNA binding site [nucleotide binding]; other site 290339010091 Preprotein translocase SecG subunit; Region: SecG; pfam03840 290339010092 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 290339010093 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 290339010094 active site 290339010095 substrate binding site [chemical binding]; other site 290339010096 metal binding site [ion binding]; metal-binding site 290339010097 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 290339010098 dihydropteroate synthase; Region: DHPS; TIGR01496 290339010099 substrate binding pocket [chemical binding]; other site 290339010100 dimer interface [polypeptide binding]; other site 290339010101 inhibitor binding site; inhibition site 290339010102 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 290339010103 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290339010104 Walker A motif; other site 290339010105 ATP binding site [chemical binding]; other site 290339010106 Walker B motif; other site 290339010107 arginine finger; other site 290339010108 Peptidase family M41; Region: Peptidase_M41; pfam01434 290339010109 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 290339010110 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290339010111 S-adenosylmethionine binding site [chemical binding]; other site 290339010112 RNA-binding protein YhbY; Provisional; Region: PRK10343 290339010113 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 290339010114 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 290339010115 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 290339010116 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 290339010117 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 290339010118 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 290339010119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290339010120 active site 290339010121 phosphorylation site [posttranslational modification] 290339010122 intermolecular recognition site; other site 290339010123 dimerization interface [polypeptide binding]; other site 290339010124 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290339010125 DNA binding site [nucleotide binding] 290339010126 sensor protein BasS/PmrB; Provisional; Region: PRK10755 290339010127 HAMP domain; Region: HAMP; pfam00672 290339010128 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290339010129 dimer interface [polypeptide binding]; other site 290339010130 phosphorylation site [posttranslational modification] 290339010131 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290339010132 ATP binding site [chemical binding]; other site 290339010133 Mg2+ binding site [ion binding]; other site 290339010134 G-X-G motif; other site 290339010135 GTPase CgtA; Reviewed; Region: obgE; PRK12298 290339010136 GTP1/OBG; Region: GTP1_OBG; pfam01018 290339010137 Obg GTPase; Region: Obg; cd01898 290339010138 G1 box; other site 290339010139 GTP/Mg2+ binding site [chemical binding]; other site 290339010140 Switch I region; other site 290339010141 G2 box; other site 290339010142 G3 box; other site 290339010143 Switch II region; other site 290339010144 G4 box; other site 290339010145 G5 box; other site 290339010146 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 290339010147 EamA-like transporter family; Region: EamA; pfam00892 290339010148 EamA-like transporter family; Region: EamA; pfam00892 290339010149 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 290339010150 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 290339010151 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 290339010152 substrate binding pocket [chemical binding]; other site 290339010153 chain length determination region; other site 290339010154 substrate-Mg2+ binding site; other site 290339010155 catalytic residues [active] 290339010156 aspartate-rich region 1; other site 290339010157 active site lid residues [active] 290339010158 aspartate-rich region 2; other site 290339010159 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 290339010160 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 290339010161 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 290339010162 hinge; other site 290339010163 active site 290339010164 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 290339010165 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 290339010166 anti sigma factor interaction site; other site 290339010167 regulatory phosphorylation site [posttranslational modification]; other site 290339010168 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 290339010169 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 290339010170 mce related protein; Region: MCE; pfam02470 290339010171 conserved hypothetical integral membrane protein; Region: TIGR00056 290339010172 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 290339010173 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 290339010174 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 290339010175 Walker A/P-loop; other site 290339010176 ATP binding site [chemical binding]; other site 290339010177 Q-loop/lid; other site 290339010178 ABC transporter signature motif; other site 290339010179 Walker B; other site 290339010180 D-loop; other site 290339010181 H-loop/switch region; other site 290339010182 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 290339010183 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 290339010184 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 290339010185 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 290339010186 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 290339010187 putative active site [active] 290339010188 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 290339010189 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 290339010190 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 290339010191 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 290339010192 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 290339010193 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 290339010194 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 290339010195 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 290339010196 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 290339010197 Walker A/P-loop; other site 290339010198 ATP binding site [chemical binding]; other site 290339010199 Q-loop/lid; other site 290339010200 ABC transporter signature motif; other site 290339010201 Walker B; other site 290339010202 D-loop; other site 290339010203 H-loop/switch region; other site 290339010204 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 290339010205 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 290339010206 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 290339010207 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 290339010208 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 290339010209 30S subunit binding site; other site 290339010210 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 290339010211 active site 290339010212 phosphorylation site [posttranslational modification] 290339010213 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 290339010214 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 290339010215 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 290339010216 dimerization domain swap beta strand [polypeptide binding]; other site 290339010217 regulatory protein interface [polypeptide binding]; other site 290339010218 active site 290339010219 regulatory phosphorylation site [posttranslational modification]; other site 290339010220 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 290339010221 Transglycosylase; Region: Transgly; cl17702 290339010222 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 290339010223 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 290339010224 conserved cys residue [active] 290339010225 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 290339010226 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290339010227 putative active site [active] 290339010228 heme pocket [chemical binding]; other site 290339010229 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290339010230 dimer interface [polypeptide binding]; other site 290339010231 phosphorylation site [posttranslational modification] 290339010232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290339010233 ATP binding site [chemical binding]; other site 290339010234 Mg2+ binding site [ion binding]; other site 290339010235 G-X-G motif; other site 290339010236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290339010237 active site 290339010238 phosphorylation site [posttranslational modification] 290339010239 intermolecular recognition site; other site 290339010240 dimerization interface [polypeptide binding]; other site 290339010241 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 290339010242 putative binding surface; other site 290339010243 active site 290339010244 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 290339010245 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 290339010246 FeS/SAM binding site; other site 290339010247 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 290339010248 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 290339010249 dimer interface [polypeptide binding]; other site 290339010250 active site 290339010251 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 290339010252 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 290339010253 active site 290339010254 FMN binding site [chemical binding]; other site 290339010255 substrate binding site [chemical binding]; other site 290339010256 3Fe-4S cluster binding site [ion binding]; other site 290339010257 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 290339010258 domain interface; other site 290339010259 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 290339010260 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290339010261 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290339010262 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 290339010263 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 290339010264 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 290339010265 Autotransporter beta-domain; Region: Autotransporter; smart00869 290339010266 Domain of unknown function (DUF386); Region: DUF386; cl01047 290339010267 N-acetylmannosamine kinase; Provisional; Region: PRK05082 290339010268 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 290339010269 nucleotide binding site [chemical binding]; other site 290339010270 putative sialic acid transporter; Provisional; Region: PRK03893 290339010271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339010272 putative substrate translocation pore; other site 290339010273 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 290339010274 N-acetylneuraminate lyase; Provisional; Region: PRK04147 290339010275 inhibitor site; inhibition site 290339010276 active site 290339010277 dimer interface [polypeptide binding]; other site 290339010278 catalytic residue [active] 290339010279 transcriptional regulator NanR; Provisional; Region: PRK03837 290339010280 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290339010281 DNA-binding site [nucleotide binding]; DNA binding site 290339010282 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 290339010283 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 290339010284 stringent starvation protein A; Provisional; Region: sspA; PRK09481 290339010285 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 290339010286 C-terminal domain interface [polypeptide binding]; other site 290339010287 putative GSH binding site (G-site) [chemical binding]; other site 290339010288 dimer interface [polypeptide binding]; other site 290339010289 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 290339010290 dimer interface [polypeptide binding]; other site 290339010291 N-terminal domain interface [polypeptide binding]; other site 290339010292 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 290339010293 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 290339010294 23S rRNA interface [nucleotide binding]; other site 290339010295 L3 interface [polypeptide binding]; other site 290339010296 Predicted ATPase [General function prediction only]; Region: COG1485 290339010297 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 290339010298 hypothetical protein; Provisional; Region: PRK11677 290339010299 serine endoprotease; Provisional; Region: PRK10139 290339010300 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 290339010301 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 290339010302 protein binding site [polypeptide binding]; other site 290339010303 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 290339010304 serine endoprotease; Provisional; Region: PRK10898 290339010305 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 290339010306 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 290339010307 protein binding site [polypeptide binding]; other site 290339010308 malate dehydrogenase; Provisional; Region: PRK05086 290339010309 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 290339010310 NAD binding site [chemical binding]; other site 290339010311 dimerization interface [polypeptide binding]; other site 290339010312 Substrate binding site [chemical binding]; other site 290339010313 arginine repressor; Provisional; Region: PRK05066 290339010314 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 290339010315 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 290339010316 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 290339010317 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 290339010318 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 290339010319 RNAase interaction site [polypeptide binding]; other site 290339010320 succinic semialdehyde dehydrogenase; Region: PLN02278 290339010321 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 290339010322 tetramerization interface [polypeptide binding]; other site 290339010323 NAD(P) binding site [chemical binding]; other site 290339010324 catalytic residues [active] 290339010325 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 290339010326 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 290339010327 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 290339010328 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 290339010329 HlyD family secretion protein; Region: HlyD_3; pfam13437 290339010330 efflux system membrane protein; Provisional; Region: PRK11594 290339010331 transcriptional regulator; Provisional; Region: PRK10632 290339010332 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339010333 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 290339010334 putative effector binding pocket; other site 290339010335 dimerization interface [polypeptide binding]; other site 290339010336 protease TldD; Provisional; Region: tldD; PRK10735 290339010337 hypothetical protein; Provisional; Region: PRK10899 290339010338 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 290339010339 ribonuclease G; Provisional; Region: PRK11712 290339010340 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 290339010341 homodimer interface [polypeptide binding]; other site 290339010342 oligonucleotide binding site [chemical binding]; other site 290339010343 Maf-like protein; Region: Maf; pfam02545 290339010344 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 290339010345 active site 290339010346 dimer interface [polypeptide binding]; other site 290339010347 rod shape-determining protein MreD; Provisional; Region: PRK11060 290339010348 rod shape-determining protein MreC; Region: mreC; TIGR00219 290339010349 rod shape-determining protein MreC; Region: MreC; pfam04085 290339010350 rod shape-determining protein MreB; Provisional; Region: PRK13927 290339010351 MreB and similar proteins; Region: MreB_like; cd10225 290339010352 nucleotide binding site [chemical binding]; other site 290339010353 Mg binding site [ion binding]; other site 290339010354 putative protofilament interaction site [polypeptide binding]; other site 290339010355 RodZ interaction site [polypeptide binding]; other site 290339010356 regulatory protein CsrD; Provisional; Region: PRK11059 290339010357 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290339010358 metal binding site [ion binding]; metal-binding site 290339010359 active site 290339010360 I-site; other site 290339010361 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290339010362 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 290339010363 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 290339010364 NADP binding site [chemical binding]; other site 290339010365 dimer interface [polypeptide binding]; other site 290339010366 TMAO/DMSO reductase; Reviewed; Region: PRK05363 290339010367 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 290339010368 Moco binding site; other site 290339010369 metal coordination site [ion binding]; other site 290339010370 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 290339010371 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 290339010372 Dehydroquinase class II; Region: DHquinase_II; pfam01220 290339010373 active site 290339010374 trimer interface [polypeptide binding]; other site 290339010375 dimer interface [polypeptide binding]; other site 290339010376 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 290339010377 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 290339010378 carboxyltransferase (CT) interaction site; other site 290339010379 biotinylation site [posttranslational modification]; other site 290339010380 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 290339010381 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 290339010382 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 290339010383 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 290339010384 hypothetical protein; Provisional; Region: PRK10633 290339010385 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 290339010386 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 290339010387 Na binding site [ion binding]; other site 290339010388 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 290339010389 Methyltransferase domain; Region: Methyltransf_18; pfam12847 290339010390 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 290339010391 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 290339010392 FMN binding site [chemical binding]; other site 290339010393 active site 290339010394 catalytic residues [active] 290339010395 substrate binding site [chemical binding]; other site 290339010396 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 290339010397 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 290339010398 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 290339010399 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 290339010400 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 290339010401 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 290339010402 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290339010403 metal binding site [ion binding]; metal-binding site 290339010404 active site 290339010405 I-site; other site 290339010406 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290339010407 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 290339010408 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290339010409 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 290339010410 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 290339010411 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 290339010412 HlyD family secretion protein; Region: HlyD_3; pfam13437 290339010413 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 290339010414 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290339010415 substrate binding pocket [chemical binding]; other site 290339010416 membrane-bound complex binding site; other site 290339010417 hinge residues; other site 290339010418 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 290339010419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339010420 conserved gate region; other site 290339010421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339010422 dimer interface [polypeptide binding]; other site 290339010423 ABC-ATPase subunit interface; other site 290339010424 putative PBP binding loops; other site 290339010425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339010426 dimer interface [polypeptide binding]; other site 290339010427 conserved gate region; other site 290339010428 putative PBP binding loops; other site 290339010429 ABC-ATPase subunit interface; other site 290339010430 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 290339010431 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 290339010432 Walker A/P-loop; other site 290339010433 ATP binding site [chemical binding]; other site 290339010434 Q-loop/lid; other site 290339010435 ABC transporter signature motif; other site 290339010436 Walker B; other site 290339010437 D-loop; other site 290339010438 H-loop/switch region; other site 290339010439 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 290339010440 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 290339010441 purine monophosphate binding site [chemical binding]; other site 290339010442 dimer interface [polypeptide binding]; other site 290339010443 putative catalytic residues [active] 290339010444 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 290339010445 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 290339010446 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 290339010447 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 290339010448 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 290339010449 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 290339010450 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 290339010451 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 290339010452 IHF dimer interface [polypeptide binding]; other site 290339010453 IHF - DNA interface [nucleotide binding]; other site 290339010454 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 290339010455 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 290339010456 Active_site [active] 290339010457 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 290339010458 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 290339010459 substrate binding site [chemical binding]; other site 290339010460 active site 290339010461 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 290339010462 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 290339010463 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 290339010464 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 290339010465 putative NADH binding site [chemical binding]; other site 290339010466 putative active site [active] 290339010467 nudix motif; other site 290339010468 putative metal binding site [ion binding]; other site 290339010469 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 290339010470 TPP riboswitch (THI element) 290339010471 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 290339010472 ThiC-associated domain; Region: ThiC-associated; pfam13667 290339010473 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 290339010474 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 290339010475 thiamine phosphate binding site [chemical binding]; other site 290339010476 active site 290339010477 pyrophosphate binding site [ion binding]; other site 290339010478 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 290339010479 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 290339010480 ATP binding site [chemical binding]; other site 290339010481 substrate interface [chemical binding]; other site 290339010482 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 290339010483 thiS-thiF/thiG interaction site; other site 290339010484 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 290339010485 ThiS interaction site; other site 290339010486 putative active site [active] 290339010487 tetramer interface [polypeptide binding]; other site 290339010488 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 290339010489 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290339010490 FeS/SAM binding site; other site 290339010491 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 290339010492 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 290339010493 active site 290339010494 P-loop; other site 290339010495 phosphorylation site [posttranslational modification] 290339010496 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 290339010497 methionine cluster; other site 290339010498 active site 290339010499 phosphorylation site [posttranslational modification] 290339010500 metal binding site [ion binding]; metal-binding site 290339010501 Helix-turn-helix domain; Region: HTH_18; pfam12833 290339010502 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290339010503 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 290339010504 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 290339010505 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 290339010506 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 290339010507 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 290339010508 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 290339010509 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 290339010510 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 290339010511 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 290339010512 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 290339010513 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 290339010514 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 290339010515 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 290339010516 DNA binding site [nucleotide binding] 290339010517 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 290339010518 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 290339010519 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 290339010520 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 290339010521 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 290339010522 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 290339010523 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 290339010524 RPB3 interaction site [polypeptide binding]; other site 290339010525 RPB1 interaction site [polypeptide binding]; other site 290339010526 RPB11 interaction site [polypeptide binding]; other site 290339010527 RPB10 interaction site [polypeptide binding]; other site 290339010528 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 290339010529 core dimer interface [polypeptide binding]; other site 290339010530 peripheral dimer interface [polypeptide binding]; other site 290339010531 L10 interface [polypeptide binding]; other site 290339010532 L11 interface [polypeptide binding]; other site 290339010533 putative EF-Tu interaction site [polypeptide binding]; other site 290339010534 putative EF-G interaction site [polypeptide binding]; other site 290339010535 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 290339010536 23S rRNA interface [nucleotide binding]; other site 290339010537 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 290339010538 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 290339010539 mRNA/rRNA interface [nucleotide binding]; other site 290339010540 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 290339010541 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 290339010542 23S rRNA interface [nucleotide binding]; other site 290339010543 L7/L12 interface [polypeptide binding]; other site 290339010544 putative thiostrepton binding site; other site 290339010545 L25 interface [polypeptide binding]; other site 290339010546 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 290339010547 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 290339010548 putative homodimer interface [polypeptide binding]; other site 290339010549 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 290339010550 heterodimer interface [polypeptide binding]; other site 290339010551 homodimer interface [polypeptide binding]; other site 290339010552 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 290339010553 elongation factor Tu; Reviewed; Region: PRK00049 290339010554 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 290339010555 G1 box; other site 290339010556 GEF interaction site [polypeptide binding]; other site 290339010557 GTP/Mg2+ binding site [chemical binding]; other site 290339010558 Switch I region; other site 290339010559 G2 box; other site 290339010560 G3 box; other site 290339010561 Switch II region; other site 290339010562 G4 box; other site 290339010563 G5 box; other site 290339010564 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 290339010565 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 290339010566 Antibiotic Binding Site [chemical binding]; other site 290339010567 pantothenate kinase; Provisional; Region: PRK05439 290339010568 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 290339010569 ATP-binding site [chemical binding]; other site 290339010570 CoA-binding site [chemical binding]; other site 290339010571 Mg2+-binding site [ion binding]; other site 290339010572 Biotin operon repressor [Transcription]; Region: BirA; COG1654 290339010573 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 290339010574 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 290339010575 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 290339010576 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 290339010577 potassium transporter; Provisional; Region: PRK10750 290339010578 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 290339010579 hypothetical protein; Provisional; Region: PRK11568 290339010580 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 290339010581 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 290339010582 proline dipeptidase; Provisional; Region: PRK13607 290339010583 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 290339010584 active site 290339010585 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 290339010586 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 290339010587 substrate binding site [chemical binding]; other site 290339010588 oxyanion hole (OAH) forming residues; other site 290339010589 trimer interface [polypeptide binding]; other site 290339010590 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 290339010591 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 290339010592 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 290339010593 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 290339010594 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 290339010595 dimer interface [polypeptide binding]; other site 290339010596 active site 290339010597 FMN reductase; Validated; Region: fre; PRK08051 290339010598 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 290339010599 FAD binding pocket [chemical binding]; other site 290339010600 FAD binding motif [chemical binding]; other site 290339010601 phosphate binding motif [ion binding]; other site 290339010602 beta-alpha-beta structure motif; other site 290339010603 NAD binding pocket [chemical binding]; other site 290339010604 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 290339010605 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 290339010606 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 290339010607 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 290339010608 active site 290339010609 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 290339010610 sec-independent translocase; Provisional; Region: PRK01770 290339010611 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 290339010612 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 290339010613 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 290339010614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 290339010615 SCP-2 sterol transfer family; Region: SCP2; pfam02036 290339010616 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 290339010617 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290339010618 S-adenosylmethionine binding site [chemical binding]; other site 290339010619 DNA recombination protein RmuC; Provisional; Region: PRK10361 290339010620 RmuC family; Region: RmuC; pfam02646 290339010621 uridine phosphorylase; Provisional; Region: PRK11178 290339010622 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 290339010623 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 290339010624 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 290339010625 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 290339010626 THF binding site; other site 290339010627 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 290339010628 substrate binding site [chemical binding]; other site 290339010629 THF binding site; other site 290339010630 zinc-binding site [ion binding]; other site 290339010631 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 290339010632 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339010633 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 290339010634 putative dimerization interface [polypeptide binding]; other site 290339010635 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 290339010636 EamA-like transporter family; Region: EamA; pfam00892 290339010637 putative hydrolase; Provisional; Region: PRK10976 290339010638 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290339010639 active site 290339010640 motif I; other site 290339010641 motif II; other site 290339010642 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 290339010643 lysophospholipase L2; Provisional; Region: PRK10749 290339010644 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 290339010645 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 290339010646 threonine efflux system; Provisional; Region: PRK10229 290339010647 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 290339010648 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290339010649 ATP binding site [chemical binding]; other site 290339010650 putative Mg++ binding site [ion binding]; other site 290339010651 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290339010652 nucleotide binding region [chemical binding]; other site 290339010653 ATP-binding site [chemical binding]; other site 290339010654 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 290339010655 HRDC domain; Region: HRDC; pfam00570 290339010656 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 290339010657 dimerization interface [polypeptide binding]; other site 290339010658 substrate binding site [chemical binding]; other site 290339010659 active site 290339010660 calcium binding site [ion binding]; other site 290339010661 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 290339010662 CoenzymeA binding site [chemical binding]; other site 290339010663 subunit interaction site [polypeptide binding]; other site 290339010664 PHB binding site; other site 290339010665 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 290339010666 EamA-like transporter family; Region: EamA; cl17759 290339010667 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 290339010668 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 290339010669 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 290339010670 Cl binding site [ion binding]; other site 290339010671 oligomer interface [polypeptide binding]; other site 290339010672 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 290339010673 Part of AAA domain; Region: AAA_19; pfam13245 290339010674 Family description; Region: UvrD_C_2; pfam13538 290339010675 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 290339010676 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290339010677 motif II; other site 290339010678 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 290339010679 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 290339010680 active site 290339010681 Int/Topo IB signature motif; other site 290339010682 hypothetical protein; Provisional; Region: PRK10963 290339010683 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 290339010684 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 290339010685 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 290339010686 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 290339010687 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 290339010688 putative iron binding site [ion binding]; other site 290339010689 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 290339010690 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 290339010691 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 290339010692 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 290339010693 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 290339010694 domain interfaces; other site 290339010695 active site 290339010696 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 290339010697 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 290339010698 active site 290339010699 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 290339010700 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 290339010701 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 290339010702 HemY protein N-terminus; Region: HemY_N; pfam07219 290339010703 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 290339010704 TPR motif; other site 290339010705 binding surface 290339010706 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 290339010707 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 290339010708 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 290339010709 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 290339010710 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 290339010711 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 290339010712 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 290339010713 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 290339010714 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 290339010715 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 290339010716 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 290339010717 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 290339010718 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 290339010719 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 290339010720 putative transport protein YifK; Provisional; Region: PRK10746 290339010721 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 290339010722 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 290339010723 putative common antigen polymerase; Provisional; Region: PRK02975 290339010724 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 290339010725 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 290339010726 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 290339010727 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 290339010728 inhibitor-cofactor binding pocket; inhibition site 290339010729 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339010730 catalytic residue [active] 290339010731 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 290339010732 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 290339010733 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 290339010734 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 290339010735 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 290339010736 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 290339010737 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 290339010738 homodimer interface [polypeptide binding]; other site 290339010739 active site 290339010740 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 290339010741 Chain length determinant protein; Region: Wzz; cl15801 290339010742 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 290339010743 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 290339010744 Mg++ binding site [ion binding]; other site 290339010745 putative catalytic motif [active] 290339010746 substrate binding site [chemical binding]; other site 290339010747 transcription termination factor Rho; Provisional; Region: rho; PRK09376 290339010748 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 290339010749 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 290339010750 RNA binding site [nucleotide binding]; other site 290339010751 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 290339010752 multimer interface [polypeptide binding]; other site 290339010753 Walker A motif; other site 290339010754 ATP binding site [chemical binding]; other site 290339010755 Walker B motif; other site 290339010756 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 290339010757 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 290339010758 catalytic residues [active] 290339010759 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 290339010760 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 290339010761 ATP binding site [chemical binding]; other site 290339010762 Mg++ binding site [ion binding]; other site 290339010763 motif III; other site 290339010764 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290339010765 nucleotide binding region [chemical binding]; other site 290339010766 ATP-binding site [chemical binding]; other site 290339010767 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 290339010768 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 290339010769 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 290339010770 Part of AAA domain; Region: AAA_19; pfam13245 290339010771 Family description; Region: UvrD_C_2; pfam13538 290339010772 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 290339010773 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 290339010774 ketol-acid reductoisomerase; Validated; Region: PRK05225 290339010775 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 290339010776 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 290339010777 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 290339010778 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339010779 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 290339010780 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 290339010781 putative dimerization interface [polypeptide binding]; other site 290339010782 threonine dehydratase; Reviewed; Region: PRK09224 290339010783 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 290339010784 tetramer interface [polypeptide binding]; other site 290339010785 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339010786 catalytic residue [active] 290339010787 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 290339010788 putative Ile/Val binding site [chemical binding]; other site 290339010789 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 290339010790 putative Ile/Val binding site [chemical binding]; other site 290339010791 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 290339010792 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 290339010793 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 290339010794 homodimer interface [polypeptide binding]; other site 290339010795 substrate-cofactor binding pocket; other site 290339010796 catalytic residue [active] 290339010797 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 290339010798 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 290339010799 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 290339010800 PYR/PP interface [polypeptide binding]; other site 290339010801 dimer interface [polypeptide binding]; other site 290339010802 TPP binding site [chemical binding]; other site 290339010803 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 290339010804 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 290339010805 TPP-binding site [chemical binding]; other site 290339010806 dimer interface [polypeptide binding]; other site 290339010807 putative ATP-dependent protease; Provisional; Region: PRK09862 290339010808 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 290339010809 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290339010810 Walker A motif; other site 290339010811 ATP binding site [chemical binding]; other site 290339010812 Walker B motif; other site 290339010813 arginine finger; other site 290339010814 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 290339010815 hypothetical protein; Provisional; Region: PRK11027 290339010816 transcriptional regulator HdfR; Provisional; Region: PRK03601 290339010817 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339010818 LysR substrate binding domain; Region: LysR_substrate; pfam03466 290339010819 dimerization interface [polypeptide binding]; other site 290339010820 glutamate racemase; Provisional; Region: PRK00865 290339010821 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 290339010822 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 290339010823 N-terminal plug; other site 290339010824 ligand-binding site [chemical binding]; other site 290339010825 cobalamin riboswitch 290339010826 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 290339010827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290339010828 S-adenosylmethionine binding site [chemical binding]; other site 290339010829 hypothetical protein; Provisional; Region: PRK11056 290339010830 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 290339010831 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290339010832 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 290339010833 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290339010834 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 290339010835 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 290339010836 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339010837 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 290339010838 dimerization interface [polypeptide binding]; other site 290339010839 argininosuccinate lyase; Provisional; Region: PRK04833 290339010840 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 290339010841 active sites [active] 290339010842 tetramer interface [polypeptide binding]; other site 290339010843 argininosuccinate synthase; Provisional; Region: PRK13820 290339010844 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 290339010845 ANP binding site [chemical binding]; other site 290339010846 Substrate Binding Site II [chemical binding]; other site 290339010847 Substrate Binding Site I [chemical binding]; other site 290339010848 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 290339010849 nucleotide binding site [chemical binding]; other site 290339010850 N-acetyl-L-glutamate binding site [chemical binding]; other site 290339010851 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 290339010852 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 290339010853 acetylornithine deacetylase; Provisional; Region: PRK05111 290339010854 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 290339010855 metal binding site [ion binding]; metal-binding site 290339010856 putative dimer interface [polypeptide binding]; other site 290339010857 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 290339010858 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 290339010859 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 290339010860 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 290339010861 PapC N-terminal domain; Region: PapC_N; pfam13954 290339010862 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 290339010863 PapC C-terminal domain; Region: PapC_C; pfam13953 290339010864 putative chaperone protein EcpD; Provisional; Region: PRK09926 290339010865 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 290339010866 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 290339010867 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 290339010868 malate:quinone oxidoreductase; Validated; Region: PRK05257 290339010869 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 290339010870 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290339010871 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 290339010872 putative active site [active] 290339010873 heme pocket [chemical binding]; other site 290339010874 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290339010875 putative active site [active] 290339010876 heme pocket [chemical binding]; other site 290339010877 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 290339010878 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 290339010879 dimer interface [polypeptide binding]; other site 290339010880 putative CheW interface [polypeptide binding]; other site 290339010881 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 290339010882 FAD binding site [chemical binding]; other site 290339010883 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 290339010884 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 290339010885 putative catalytic residues [active] 290339010886 putative nucleotide binding site [chemical binding]; other site 290339010887 putative aspartate binding site [chemical binding]; other site 290339010888 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 290339010889 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 290339010890 cystathionine gamma-synthase; Provisional; Region: PRK08045 290339010891 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 290339010892 homodimer interface [polypeptide binding]; other site 290339010893 substrate-cofactor binding pocket; other site 290339010894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339010895 catalytic residue [active] 290339010896 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 290339010897 dimerization interface [polypeptide binding]; other site 290339010898 DNA binding site [nucleotide binding] 290339010899 corepressor binding sites; other site 290339010900 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 290339010901 primosome assembly protein PriA; Validated; Region: PRK05580 290339010902 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290339010903 ATP binding site [chemical binding]; other site 290339010904 putative Mg++ binding site [ion binding]; other site 290339010905 helicase superfamily c-terminal domain; Region: HELICc; smart00490 290339010906 ATP-binding site [chemical binding]; other site 290339010907 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290339010908 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 290339010909 DNA binding site [nucleotide binding] 290339010910 domain linker motif; other site 290339010911 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 290339010912 dimerization interface [polypeptide binding]; other site 290339010913 ligand binding site [chemical binding]; other site 290339010914 cell division protein FtsN; Provisional; Region: PRK12757 290339010915 Sporulation related domain; Region: SPOR; cl10051 290339010916 Sporulation related domain; Region: SPOR; cl10051 290339010917 cell division protein FtsN; Provisional; Region: PRK12757 290339010918 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 290339010919 active site 290339010920 HslU subunit interaction site [polypeptide binding]; other site 290339010921 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 290339010922 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290339010923 Walker A motif; other site 290339010924 ATP binding site [chemical binding]; other site 290339010925 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290339010926 Walker B motif; other site 290339010927 arginine finger; other site 290339010928 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 290339010929 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 290339010930 UbiA prenyltransferase family; Region: UbiA; pfam01040 290339010931 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 290339010932 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3074 290339010933 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 290339010934 amphipathic channel; other site 290339010935 Asn-Pro-Ala signature motifs; other site 290339010936 glycerol kinase; Provisional; Region: glpK; PRK00047 290339010937 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 290339010938 N- and C-terminal domain interface [polypeptide binding]; other site 290339010939 active site 290339010940 MgATP binding site [chemical binding]; other site 290339010941 catalytic site [active] 290339010942 metal binding site [ion binding]; metal-binding site 290339010943 glycerol binding site [chemical binding]; other site 290339010944 homotetramer interface [polypeptide binding]; other site 290339010945 homodimer interface [polypeptide binding]; other site 290339010946 FBP binding site [chemical binding]; other site 290339010947 protein IIAGlc interface [polypeptide binding]; other site 290339010948 hypothetical protein; Provisional; Region: PRK11020 290339010949 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 290339010950 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290339010951 non-specific DNA binding site [nucleotide binding]; other site 290339010952 salt bridge; other site 290339010953 sequence-specific DNA binding site [nucleotide binding]; other site 290339010954 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 290339010955 L-lactate permease; Provisional; Region: PRK10420 290339010956 glycolate transporter; Provisional; Region: PRK09695 290339010957 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 290339010958 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290339010959 DNA-binding site [nucleotide binding]; DNA binding site 290339010960 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 290339010961 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 290339010962 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 290339010963 active site 290339010964 substrate binding site [chemical binding]; other site 290339010965 FMN binding site [chemical binding]; other site 290339010966 putative catalytic residues [active] 290339010967 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 290339010968 MOSC domain; Region: MOSC; pfam03473 290339010969 3-alpha domain; Region: 3-alpha; pfam03475 290339010970 superoxide dismutase; Provisional; Region: PRK10925 290339010971 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 290339010972 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 290339010973 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 290339010974 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 290339010975 transcriptional activator RhaR; Provisional; Region: PRK13502 290339010976 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 290339010977 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290339010978 transcriptional activator RhaS; Provisional; Region: PRK13503 290339010979 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 290339010980 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290339010981 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290339010982 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 290339010983 N- and C-terminal domain interface [polypeptide binding]; other site 290339010984 active site 290339010985 putative catalytic site [active] 290339010986 metal binding site [ion binding]; metal-binding site 290339010987 ATP binding site [chemical binding]; other site 290339010988 carbohydrate binding site [chemical binding]; other site 290339010989 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 290339010990 L-rhamnose isomerase; Provisional; Region: PRK01076 290339010991 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 290339010992 intersubunit interface [polypeptide binding]; other site 290339010993 active site 290339010994 Zn2+ binding site [ion binding]; other site 290339010995 lactaldehyde reductase; Region: lactal_redase; TIGR02638 290339010996 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 290339010997 dimer interface [polypeptide binding]; other site 290339010998 active site 290339010999 metal binding site [ion binding]; metal-binding site 290339011000 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 290339011001 galactoside permease; Reviewed; Region: lacY; PRK09528 290339011002 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339011003 putative substrate translocation pore; other site 290339011004 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 290339011005 Melibiase; Region: Melibiase; pfam02065 290339011006 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290339011007 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290339011008 DNA binding site [nucleotide binding] 290339011009 domain linker motif; other site 290339011010 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 290339011011 ligand binding site [chemical binding]; other site 290339011012 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 290339011013 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290339011014 non-specific DNA binding site [nucleotide binding]; other site 290339011015 salt bridge; other site 290339011016 sequence-specific DNA binding site [nucleotide binding]; other site 290339011017 Cupin domain; Region: Cupin_2; cl17218 290339011018 AzlC protein; Region: AzlC; cl00570 290339011019 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 290339011020 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 290339011021 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 290339011022 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 290339011023 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 290339011024 molybdopterin cofactor binding site; other site 290339011025 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 290339011026 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 290339011027 molybdopterin cofactor binding site; other site 290339011028 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 290339011029 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 290339011030 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 290339011031 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 290339011032 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 290339011033 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 290339011034 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290339011035 non-specific DNA binding site [nucleotide binding]; other site 290339011036 salt bridge; other site 290339011037 sequence-specific DNA binding site [nucleotide binding]; other site 290339011038 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 290339011039 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 290339011040 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290339011041 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 290339011042 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 290339011043 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 290339011044 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 290339011045 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 290339011046 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 290339011047 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 290339011048 nucleotide binding site [chemical binding]; other site 290339011049 putative alcohol dehydrogenase; Provisional; Region: PRK09860 290339011050 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 290339011051 dimer interface [polypeptide binding]; other site 290339011052 active site 290339011053 metal binding site [ion binding]; metal-binding site 290339011054 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 290339011055 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 290339011056 G1 box; other site 290339011057 putative GEF interaction site [polypeptide binding]; other site 290339011058 GTP/Mg2+ binding site [chemical binding]; other site 290339011059 Switch I region; other site 290339011060 G2 box; other site 290339011061 G3 box; other site 290339011062 Switch II region; other site 290339011063 G4 box; other site 290339011064 G5 box; other site 290339011065 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 290339011066 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 290339011067 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 290339011068 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 290339011069 selenocysteine synthase; Provisional; Region: PRK04311 290339011070 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 290339011071 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 290339011072 putative glutathione S-transferase; Provisional; Region: PRK10357 290339011073 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 290339011074 putative C-terminal domain interface [polypeptide binding]; other site 290339011075 putative GSH binding site (G-site) [chemical binding]; other site 290339011076 putative dimer interface [polypeptide binding]; other site 290339011077 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 290339011078 dimer interface [polypeptide binding]; other site 290339011079 N-terminal domain interface [polypeptide binding]; other site 290339011080 putative substrate binding pocket (H-site) [chemical binding]; other site 290339011081 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 290339011082 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 290339011083 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 290339011084 active site 290339011085 P-loop; other site 290339011086 phosphorylation site [posttranslational modification] 290339011087 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 290339011088 active site 290339011089 phosphorylation site [posttranslational modification] 290339011090 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 290339011091 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 290339011092 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 290339011093 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 290339011094 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 290339011095 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 290339011096 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 290339011097 putative active site [active] 290339011098 ferredoxin-NADP reductase; Provisional; Region: PRK10926 290339011099 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 290339011100 FAD binding pocket [chemical binding]; other site 290339011101 FAD binding motif [chemical binding]; other site 290339011102 phosphate binding motif [ion binding]; other site 290339011103 beta-alpha-beta structure motif; other site 290339011104 NAD binding pocket [chemical binding]; other site 290339011105 Predicted membrane protein [Function unknown]; Region: COG3152 290339011106 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 290339011107 triosephosphate isomerase; Provisional; Region: PRK14567 290339011108 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 290339011109 substrate binding site [chemical binding]; other site 290339011110 dimer interface [polypeptide binding]; other site 290339011111 catalytic triad [active] 290339011112 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 290339011113 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 290339011114 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 290339011115 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 290339011116 RHS protein; Region: RHS; pfam03527 290339011117 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 290339011118 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 290339011119 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 290339011120 RHS protein; Region: RHS; pfam03527 290339011121 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 290339011122 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 290339011123 PAAR motif; Region: PAAR_motif; pfam05488 290339011124 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 290339011125 RHS Repeat; Region: RHS_repeat; pfam05593 290339011126 RHS Repeat; Region: RHS_repeat; pfam05593 290339011127 RHS Repeat; Region: RHS_repeat; cl11982 290339011128 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 290339011129 RHS Repeat; Region: RHS_repeat; pfam05593 290339011130 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 290339011131 RHS protein; Region: RHS; pfam03527 290339011132 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 290339011133 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 290339011134 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 290339011135 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 290339011136 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 290339011137 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 290339011138 RHS protein; Region: RHS; pfam03527 290339011139 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 290339011140 RHS Repeat; Region: RHS_repeat; pfam05593 290339011141 RHS Repeat; Region: RHS_repeat; pfam05593 290339011142 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 290339011143 RHS Repeat; Region: RHS_repeat; pfam05593 290339011144 RHS Repeat; Region: RHS_repeat; pfam05593 290339011145 RHS protein; Region: RHS; pfam03527 290339011146 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 290339011147 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 290339011148 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 290339011149 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 290339011150 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 290339011151 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 290339011152 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 290339011153 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 290339011154 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 290339011155 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 290339011156 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 290339011157 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 290339011158 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 290339011159 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 290339011160 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 290339011161 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 290339011162 Catalytic domain of Protein Kinases; Region: PKc; cd00180 290339011163 active site 290339011164 ATP binding site [chemical binding]; other site 290339011165 substrate binding site [chemical binding]; other site 290339011166 activation loop (A-loop); other site 290339011167 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 290339011168 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290339011169 Walker A motif; other site 290339011170 ATP binding site [chemical binding]; other site 290339011171 Walker B motif; other site 290339011172 arginine finger; other site 290339011173 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290339011174 Walker A motif; other site 290339011175 ATP binding site [chemical binding]; other site 290339011176 Walker B motif; other site 290339011177 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 290339011178 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 290339011179 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 290339011180 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 290339011181 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 290339011182 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 290339011183 ImpE protein; Region: ImpE; pfam07024 290339011184 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 290339011185 active site 290339011186 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 290339011187 phosphopeptide binding site; other site 290339011188 Protein of unknown function (DUF796); Region: DUF796; pfam05638 290339011189 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 290339011190 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 290339011191 Protein of unknown function (DUF877); Region: DUF877; pfam05943 290339011192 Protein of unknown function (DUF770); Region: DUF770; pfam05591 290339011193 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 290339011194 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 290339011195 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 290339011196 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 290339011197 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 290339011198 G1 box; other site 290339011199 GTP/Mg2+ binding site [chemical binding]; other site 290339011200 G2 box; other site 290339011201 Switch I region; other site 290339011202 G3 box; other site 290339011203 Switch II region; other site 290339011204 G4 box; other site 290339011205 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 290339011206 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 290339011207 hypothetical protein; Provisional; Region: PRK07033 290339011208 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 290339011209 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 290339011210 ligand binding site [chemical binding]; other site 290339011211 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 290339011212 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 290339011213 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 290339011214 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290339011215 Coenzyme A binding pocket [chemical binding]; other site 290339011216 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 290339011217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339011218 putative substrate translocation pore; other site 290339011219 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 290339011220 Domain of unknown function (DUF202); Region: DUF202; cl09954 290339011221 Predicted membrane protein [Function unknown]; Region: COG2149 290339011222 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 290339011223 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 290339011224 NAD binding site [chemical binding]; other site 290339011225 sugar binding site [chemical binding]; other site 290339011226 divalent metal binding site [ion binding]; other site 290339011227 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 290339011228 dimer interface [polypeptide binding]; other site 290339011229 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 290339011230 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 290339011231 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 290339011232 active site turn [active] 290339011233 phosphorylation site [posttranslational modification] 290339011234 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 290339011235 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290339011236 DNA-binding site [nucleotide binding]; DNA binding site 290339011237 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 290339011238 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 290339011239 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 290339011240 putative dimer interface [polypeptide binding]; other site 290339011241 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 290339011242 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 290339011243 putative dimer interface [polypeptide binding]; other site 290339011244 hypothetical protein; Provisional; Region: PRK11616 290339011245 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 290339011246 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 290339011247 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 290339011248 putative ligand binding site [chemical binding]; other site 290339011249 NAD binding site [chemical binding]; other site 290339011250 catalytic site [active] 290339011251 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 290339011252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339011253 putative substrate translocation pore; other site 290339011254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339011255 D-galactonate transporter; Region: 2A0114; TIGR00893 290339011256 putative substrate translocation pore; other site 290339011257 galactonate dehydratase; Provisional; Region: PRK14017 290339011258 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 290339011259 putative active site pocket [active] 290339011260 putative metal binding site [ion binding]; other site 290339011261 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 290339011262 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 290339011263 active site 290339011264 intersubunit interface [polypeptide binding]; other site 290339011265 catalytic residue [active] 290339011266 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 290339011267 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 290339011268 Transcriptional regulators [Transcription]; Region: FadR; COG2186 290339011269 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290339011270 DNA-binding site [nucleotide binding]; DNA binding site 290339011271 FCD domain; Region: FCD; pfam07729 290339011272 sugar phosphate phosphatase; Provisional; Region: PRK10513 290339011273 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290339011274 active site 290339011275 motif I; other site 290339011276 motif II; other site 290339011277 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290339011278 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 290339011279 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290339011280 Mg2+ binding site [ion binding]; other site 290339011281 G-X-G motif; other site 290339011282 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 290339011283 anchoring element; other site 290339011284 dimer interface [polypeptide binding]; other site 290339011285 ATP binding site [chemical binding]; other site 290339011286 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 290339011287 active site 290339011288 putative metal-binding site [ion binding]; other site 290339011289 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 290339011290 recF protein; Region: recf; TIGR00611 290339011291 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290339011292 Walker A/P-loop; other site 290339011293 ATP binding site [chemical binding]; other site 290339011294 Q-loop/lid; other site 290339011295 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290339011296 ABC transporter signature motif; other site 290339011297 Walker B; other site 290339011298 D-loop; other site 290339011299 H-loop/switch region; other site 290339011300 DNA polymerase III subunit beta; Validated; Region: PRK05643 290339011301 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 290339011302 putative DNA binding surface [nucleotide binding]; other site 290339011303 dimer interface [polypeptide binding]; other site 290339011304 beta-clamp/clamp loader binding surface; other site 290339011305 beta-clamp/translesion DNA polymerase binding surface; other site 290339011306 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 290339011307 DnaA N-terminal domain; Region: DnaA_N; pfam11638 290339011308 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290339011309 Walker A motif; other site 290339011310 ATP binding site [chemical binding]; other site 290339011311 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 290339011312 Walker B motif; other site 290339011313 arginine finger; other site 290339011314 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 290339011315 DnaA box-binding interface [nucleotide binding]; other site 290339011316 ribonuclease P; Reviewed; Region: rnpA; PRK01732 290339011317 membrane protein insertase; Provisional; Region: PRK01318 290339011318 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 290339011319 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 290339011320 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 290339011321 trmE is a tRNA modification GTPase; Region: trmE; cd04164 290339011322 G1 box; other site 290339011323 GTP/Mg2+ binding site [chemical binding]; other site 290339011324 Switch I region; other site 290339011325 G2 box; other site 290339011326 Switch II region; other site 290339011327 G3 box; other site 290339011328 G4 box; other site 290339011329 G5 box; other site 290339011330 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 290339011331 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 290339011332 active site residue [active] 290339011333 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 290339011334 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 290339011335 ligand binding site [chemical binding]; other site 290339011336 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 290339011337 AzlC protein; Region: AzlC; cl00570 290339011338 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290339011339 Coenzyme A binding pocket [chemical binding]; other site 290339011340 Biofilm formation and stress response factor; Region: BsmA; pfam10014 290339011341 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290339011342 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339011343 Predicted flavoprotein [General function prediction only]; Region: COG0431 290339011344 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 290339011345 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 290339011346 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 290339011347 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290339011348 active site 290339011349 motif I; other site 290339011350 motif II; other site 290339011351 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 290339011352 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 290339011353 transcriptional regulator PhoU; Provisional; Region: PRK11115 290339011354 PhoU domain; Region: PhoU; pfam01895 290339011355 PhoU domain; Region: PhoU; pfam01895 290339011356 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 290339011357 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 290339011358 Walker A/P-loop; other site 290339011359 ATP binding site [chemical binding]; other site 290339011360 Q-loop/lid; other site 290339011361 ABC transporter signature motif; other site 290339011362 Walker B; other site 290339011363 D-loop; other site 290339011364 H-loop/switch region; other site 290339011365 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 290339011366 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339011367 dimer interface [polypeptide binding]; other site 290339011368 conserved gate region; other site 290339011369 putative PBP binding loops; other site 290339011370 ABC-ATPase subunit interface; other site 290339011371 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 290339011372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339011373 dimer interface [polypeptide binding]; other site 290339011374 conserved gate region; other site 290339011375 putative PBP binding loops; other site 290339011376 ABC-ATPase subunit interface; other site 290339011377 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290339011378 substrate binding pocket [chemical binding]; other site 290339011379 membrane-bound complex binding site; other site 290339011380 hinge residues; other site 290339011381 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 290339011382 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 290339011383 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 290339011384 glutaminase active site [active] 290339011385 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 290339011386 dimer interface [polypeptide binding]; other site 290339011387 active site 290339011388 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 290339011389 dimer interface [polypeptide binding]; other site 290339011390 active site 290339011391 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 290339011392 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 290339011393 Substrate binding site; other site 290339011394 Mg++ binding site; other site 290339011395 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 290339011396 active site 290339011397 substrate binding site [chemical binding]; other site 290339011398 CoA binding site [chemical binding]; other site 290339011399 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 290339011400 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 290339011401 gamma subunit interface [polypeptide binding]; other site 290339011402 epsilon subunit interface [polypeptide binding]; other site 290339011403 LBP interface [polypeptide binding]; other site 290339011404 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 290339011405 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 290339011406 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 290339011407 alpha subunit interaction interface [polypeptide binding]; other site 290339011408 Walker A motif; other site 290339011409 ATP binding site [chemical binding]; other site 290339011410 Walker B motif; other site 290339011411 inhibitor binding site; inhibition site 290339011412 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 290339011413 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 290339011414 core domain interface [polypeptide binding]; other site 290339011415 delta subunit interface [polypeptide binding]; other site 290339011416 epsilon subunit interface [polypeptide binding]; other site 290339011417 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 290339011418 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 290339011419 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 290339011420 beta subunit interaction interface [polypeptide binding]; other site 290339011421 Walker A motif; other site 290339011422 ATP binding site [chemical binding]; other site 290339011423 Walker B motif; other site 290339011424 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 290339011425 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 290339011426 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 290339011427 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 290339011428 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 290339011429 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 290339011430 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 290339011431 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 290339011432 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 290339011433 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 290339011434 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290339011435 S-adenosylmethionine binding site [chemical binding]; other site 290339011436 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 290339011437 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 290339011438 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 290339011439 FMN-binding protein MioC; Provisional; Region: PRK09004 290339011440 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 290339011441 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290339011442 putative DNA binding site [nucleotide binding]; other site 290339011443 putative Zn2+ binding site [ion binding]; other site 290339011444 AsnC family; Region: AsnC_trans_reg; pfam01037 290339011445 Asparagine synthetase A [Amino acid transport and metabolism]; Region: AsnA; COG2502 290339011446 motif 1; other site 290339011447 dimer interface [polypeptide binding]; other site 290339011448 active site 290339011449 motif 2; other site 290339011450 motif 3; other site 290339011451 hypothetical protein; Provisional; Region: yieM; PRK10997 290339011452 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 290339011453 metal ion-dependent adhesion site (MIDAS); other site 290339011454 regulatory ATPase RavA; Provisional; Region: PRK13531 290339011455 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290339011456 Walker A motif; other site 290339011457 ATP binding site [chemical binding]; other site 290339011458 Walker B motif; other site 290339011459 arginine finger; other site 290339011460 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 290339011461 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 290339011462 potassium uptake protein; Region: kup; TIGR00794 290339011463 D-ribose pyranase; Provisional; Region: PRK11797 290339011464 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 290339011465 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 290339011466 Walker A/P-loop; other site 290339011467 ATP binding site [chemical binding]; other site 290339011468 Q-loop/lid; other site 290339011469 ABC transporter signature motif; other site 290339011470 Walker B; other site 290339011471 D-loop; other site 290339011472 H-loop/switch region; other site 290339011473 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 290339011474 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290339011475 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290339011476 TM-ABC transporter signature motif; other site 290339011477 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 290339011478 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 290339011479 ligand binding site [chemical binding]; other site 290339011480 dimerization interface [polypeptide binding]; other site 290339011481 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290339011482 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 290339011483 substrate binding site [chemical binding]; other site 290339011484 dimer interface [polypeptide binding]; other site 290339011485 ATP binding site [chemical binding]; other site 290339011486 transcriptional repressor RbsR; Provisional; Region: PRK10423 290339011487 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290339011488 DNA binding site [nucleotide binding] 290339011489 domain linker motif; other site 290339011490 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 290339011491 dimerization interface [polypeptide binding]; other site 290339011492 ligand binding site [chemical binding]; other site 290339011493 putative transporter; Provisional; Region: PRK10504 290339011494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339011495 putative substrate translocation pore; other site 290339011496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339011497 Transcriptional regulators [Transcription]; Region: FadR; COG2186 290339011498 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290339011499 DNA-binding site [nucleotide binding]; DNA binding site 290339011500 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 290339011501 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 290339011502 Walker A motif; other site 290339011503 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 290339011504 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 290339011505 GTP binding site; other site 290339011506 Protein of unknown function (DUF1040); Region: DUF1040; cl01176 290339011507 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 290339011508 serine/threonine protein kinase; Provisional; Region: PRK11768 290339011509 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 290339011510 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 290339011511 catalytic residues [active] 290339011512 hinge region; other site 290339011513 alpha helical domain; other site 290339011514 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 290339011515 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 290339011516 putative acyl-acceptor binding pocket; other site 290339011517 DNA polymerase I; Provisional; Region: PRK05755 290339011518 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 290339011519 active site 290339011520 metal binding site 1 [ion binding]; metal-binding site 290339011521 putative 5' ssDNA interaction site; other site 290339011522 metal binding site 3; metal-binding site 290339011523 metal binding site 2 [ion binding]; metal-binding site 290339011524 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 290339011525 putative DNA binding site [nucleotide binding]; other site 290339011526 putative metal binding site [ion binding]; other site 290339011527 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 290339011528 active site 290339011529 catalytic site [active] 290339011530 substrate binding site [chemical binding]; other site 290339011531 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 290339011532 active site 290339011533 DNA binding site [nucleotide binding] 290339011534 catalytic site [active] 290339011535 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 290339011536 G1 box; other site 290339011537 GTP/Mg2+ binding site [chemical binding]; other site 290339011538 Switch I region; other site 290339011539 G2 box; other site 290339011540 G3 box; other site 290339011541 Switch II region; other site 290339011542 G4 box; other site 290339011543 G5 box; other site 290339011544 Der GTPase activator; Provisional; Region: PRK05244 290339011545 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 290339011546 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290339011547 FeS/SAM binding site; other site 290339011548 HemN C-terminal domain; Region: HemN_C; pfam06969 290339011549 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 290339011550 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290339011551 active site 290339011552 phosphorylation site [posttranslational modification] 290339011553 intermolecular recognition site; other site 290339011554 dimerization interface [polypeptide binding]; other site 290339011555 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290339011556 Walker A motif; other site 290339011557 ATP binding site [chemical binding]; other site 290339011558 Walker B motif; other site 290339011559 arginine finger; other site 290339011560 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 290339011561 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 290339011562 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290339011563 putative active site [active] 290339011564 heme pocket [chemical binding]; other site 290339011565 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290339011566 dimer interface [polypeptide binding]; other site 290339011567 phosphorylation site [posttranslational modification] 290339011568 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290339011569 ATP binding site [chemical binding]; other site 290339011570 Mg2+ binding site [ion binding]; other site 290339011571 G-X-G motif; other site 290339011572 glutamine synthetase; Provisional; Region: glnA; PRK09469 290339011573 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 290339011574 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 290339011575 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 290339011576 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 290339011577 G1 box; other site 290339011578 putative GEF interaction site [polypeptide binding]; other site 290339011579 GTP/Mg2+ binding site [chemical binding]; other site 290339011580 Switch I region; other site 290339011581 G2 box; other site 290339011582 G3 box; other site 290339011583 Switch II region; other site 290339011584 G4 box; other site 290339011585 G5 box; other site 290339011586 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 290339011587 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 290339011588 outer membrane porin L; Provisional; Region: ompL; PRK09980 290339011589 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 290339011590 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 290339011591 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 290339011592 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339011593 putative substrate translocation pore; other site 290339011594 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 290339011595 alpha-glucosidase; Provisional; Region: PRK10426 290339011596 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 290339011597 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 290339011598 putative active site [active] 290339011599 putative catalytic site [active] 290339011600 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 290339011601 active site 290339011602 catalytic residues [active] 290339011603 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 290339011604 dimerization interface [polypeptide binding]; other site 290339011605 putative active cleft [active] 290339011606 Class I aldolases; Region: Aldolase_Class_I; cl17187 290339011607 catalytic residue [active] 290339011608 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 290339011609 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 290339011610 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290339011611 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 290339011612 substrate binding site [chemical binding]; other site 290339011613 ATP binding site [chemical binding]; other site 290339011614 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 290339011615 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 290339011616 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 290339011617 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 290339011618 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290339011619 motif II; other site 290339011620 hypothetical protein; Reviewed; Region: PRK01637 290339011621 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 290339011622 putative active site [active] 290339011623 dimerization interface [polypeptide binding]; other site 290339011624 putative tRNAtyr binding site [nucleotide binding]; other site 290339011625 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290339011626 Coenzyme A binding pocket [chemical binding]; other site 290339011627 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 290339011628 AsmA family; Region: AsmA; pfam05170 290339011629 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 290339011630 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 290339011631 Fimbrial protein; Region: Fimbrial; pfam00419 290339011632 Fimbrial protein; Region: Fimbrial; cl01416 290339011633 Fimbrial protein; Region: Fimbrial; pfam00419 290339011634 Fimbrial protein; Region: Fimbrial; pfam00419 290339011635 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 290339011636 PapC N-terminal domain; Region: PapC_N; pfam13954 290339011637 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 290339011638 PapC C-terminal domain; Region: PapC_C; pfam13953 290339011639 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 290339011640 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 290339011641 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 290339011642 Fimbrial protein; Region: Fimbrial; pfam00419 290339011643 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 290339011644 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 290339011645 generic binding surface II; other site 290339011646 ssDNA binding site; other site 290339011647 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290339011648 ATP binding site [chemical binding]; other site 290339011649 putative Mg++ binding site [ion binding]; other site 290339011650 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290339011651 nucleotide binding region [chemical binding]; other site 290339011652 ATP-binding site [chemical binding]; other site 290339011653 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 290339011654 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 290339011655 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 290339011656 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 290339011657 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 290339011658 Zn2+ binding site [ion binding]; other site 290339011659 Mg2+ binding site [ion binding]; other site 290339011660 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 290339011661 synthetase active site [active] 290339011662 NTP binding site [chemical binding]; other site 290339011663 metal binding site [ion binding]; metal-binding site 290339011664 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 290339011665 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 290339011666 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 290339011667 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 290339011668 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 290339011669 catalytic site [active] 290339011670 G-X2-G-X-G-K; other site 290339011671 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 290339011672 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 290339011673 nucleotide binding pocket [chemical binding]; other site 290339011674 K-X-D-G motif; other site 290339011675 catalytic site [active] 290339011676 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 290339011677 Predicted membrane protein [Function unknown]; Region: COG2860 290339011678 UPF0126 domain; Region: UPF0126; pfam03458 290339011679 UPF0126 domain; Region: UPF0126; pfam03458 290339011680 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 290339011681 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290339011682 non-specific DNA binding site [nucleotide binding]; other site 290339011683 salt bridge; other site 290339011684 sequence-specific DNA binding site [nucleotide binding]; other site 290339011685 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 290339011686 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 290339011687 integrase; Provisional; Region: PRK09692 290339011688 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 290339011689 active site 290339011690 Int/Topo IB signature motif; other site 290339011691 hypothetical protein; Provisional; Region: PRK11820 290339011692 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 290339011693 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 290339011694 ribonuclease PH; Reviewed; Region: rph; PRK00173 290339011695 Ribonuclease PH; Region: RNase_PH_bact; cd11362 290339011696 hexamer interface [polypeptide binding]; other site 290339011697 active site 290339011698 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290339011699 active site 290339011700 division inhibitor protein; Provisional; Region: slmA; PRK09480 290339011701 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290339011702 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 290339011703 trimer interface [polypeptide binding]; other site 290339011704 active site 290339011705 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 290339011706 Flavoprotein; Region: Flavoprotein; pfam02441 290339011707 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 290339011708 hypothetical protein; Reviewed; Region: PRK00024 290339011709 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 290339011710 MPN+ (JAMM) motif; other site 290339011711 Zinc-binding site [ion binding]; other site 290339011712 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 290339011713 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 290339011714 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 290339011715 DNA binding site [nucleotide binding] 290339011716 catalytic residue [active] 290339011717 H2TH interface [polypeptide binding]; other site 290339011718 putative catalytic residues [active] 290339011719 turnover-facilitating residue; other site 290339011720 intercalation triad [nucleotide binding]; other site 290339011721 8OG recognition residue [nucleotide binding]; other site 290339011722 putative reading head residues; other site 290339011723 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 290339011724 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 290339011725 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 290339011726 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 290339011727 active site 290339011728 (T/H)XGH motif; other site 290339011729 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 290339011730 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 290339011731 putative metal binding site; other site 290339011732 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 290339011733 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 290339011734 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290339011735 Sulfatase; Region: Sulfatase; cl17466 290339011736 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290339011737 putative glycosyl transferase; Provisional; Region: PRK10073 290339011738 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 290339011739 active site 290339011740 O-Antigen ligase; Region: Wzy_C; cl04850 290339011741 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290339011742 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 290339011743 putative ADP-binding pocket [chemical binding]; other site 290339011744 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290339011745 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 290339011746 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 290339011747 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 290339011748 putative active site [active] 290339011749 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 290339011750 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 290339011751 putative active site [active] 290339011752 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 290339011753 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 290339011754 putative active site [active] 290339011755 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 290339011756 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 290339011757 NADP binding site [chemical binding]; other site 290339011758 homopentamer interface [polypeptide binding]; other site 290339011759 substrate binding site [chemical binding]; other site 290339011760 active site 290339011761 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 290339011762 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 290339011763 substrate-cofactor binding pocket; other site 290339011764 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339011765 catalytic residue [active] 290339011766 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 290339011767 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 290339011768 NAD(P) binding site [chemical binding]; other site 290339011769 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 290339011770 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 290339011771 putative metal binding site; other site 290339011772 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 290339011773 NodB motif; other site 290339011774 putative active site [active] 290339011775 putative catalytic site [active] 290339011776 Zn binding site [ion binding]; other site 290339011777 AmiB activator; Provisional; Region: PRK11637 290339011778 Peptidase family M23; Region: Peptidase_M23; pfam01551 290339011779 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 290339011780 phosphoglyceromutase; Provisional; Region: PRK05434 290339011781 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 290339011782 active site residue [active] 290339011783 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 290339011784 GSH binding site [chemical binding]; other site 290339011785 catalytic residues [active] 290339011786 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 290339011787 SecA binding site; other site 290339011788 Preprotein binding site; other site 290339011789 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 290339011790 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 290339011791 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 290339011792 serine acetyltransferase; Provisional; Region: cysE; PRK11132 290339011793 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 290339011794 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 290339011795 trimer interface [polypeptide binding]; other site 290339011796 active site 290339011797 substrate binding site [chemical binding]; other site 290339011798 CoA binding site [chemical binding]; other site 290339011799 putative rRNA methylase; Provisional; Region: PRK10358 290339011800 two-component sensor protein; Provisional; Region: cpxA; PRK09470 290339011801 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 290339011802 dimerization interface [polypeptide binding]; other site 290339011803 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290339011804 dimer interface [polypeptide binding]; other site 290339011805 phosphorylation site [posttranslational modification] 290339011806 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290339011807 ATP binding site [chemical binding]; other site 290339011808 Mg2+ binding site [ion binding]; other site 290339011809 G-X-G motif; other site 290339011810 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 290339011811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290339011812 active site 290339011813 intermolecular recognition site; other site 290339011814 dimerization interface [polypeptide binding]; other site 290339011815 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290339011816 DNA binding site [nucleotide binding] 290339011817 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 290339011818 dimer interface [polypeptide binding]; other site 290339011819 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 290339011820 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 290339011821 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 290339011822 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 290339011823 active site 290339011824 ADP/pyrophosphate binding site [chemical binding]; other site 290339011825 dimerization interface [polypeptide binding]; other site 290339011826 allosteric effector site; other site 290339011827 fructose-1,6-bisphosphate binding site; other site 290339011828 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290339011829 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 290339011830 substrate binding pocket [chemical binding]; other site 290339011831 membrane-bound complex binding site; other site 290339011832 hinge residues; other site 290339011833 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 290339011834 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 290339011835 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 290339011836 transmembrane helices; other site 290339011837 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 290339011838 active site 290339011839 homotetramer interface [polypeptide binding]; other site 290339011840 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 290339011841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290339011842 active site 290339011843 phosphorylation site [posttranslational modification] 290339011844 intermolecular recognition site; other site 290339011845 dimerization interface [polypeptide binding]; other site 290339011846 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290339011847 DNA binding site [nucleotide binding] 290339011848 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 290339011849 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290339011850 dimer interface [polypeptide binding]; other site 290339011851 phosphorylation site [posttranslational modification] 290339011852 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290339011853 ATP binding site [chemical binding]; other site 290339011854 G-X-G motif; other site 290339011855 CAAX protease self-immunity; Region: Abi; pfam02517 290339011856 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 290339011857 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 290339011858 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 290339011859 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 290339011860 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 290339011861 putative NAD(P) binding site [chemical binding]; other site 290339011862 putative substrate binding site [chemical binding]; other site 290339011863 catalytic Zn binding site [ion binding]; other site 290339011864 structural Zn binding site [ion binding]; other site 290339011865 dimer interface [polypeptide binding]; other site 290339011866 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 290339011867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339011868 putative substrate translocation pore; other site 290339011869 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290339011870 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339011871 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 290339011872 putative effector binding pocket; other site 290339011873 putative dimerization interface [polypeptide binding]; other site 290339011874 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 290339011875 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 290339011876 putative metal binding site; other site 290339011877 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290339011878 binding surface 290339011879 TPR motif; other site 290339011880 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 290339011881 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 290339011882 catalytic loop [active] 290339011883 iron binding site [ion binding]; other site 290339011884 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 290339011885 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 290339011886 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 290339011887 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 290339011888 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 290339011889 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 290339011890 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 290339011891 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 290339011892 XdhC Rossmann domain; Region: XdhC_C; pfam13478 290339011893 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 290339011894 Ligand binding site; other site 290339011895 metal-binding site 290339011896 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290339011897 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290339011898 active site 290339011899 catalytic tetrad [active] 290339011900 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290339011901 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290339011902 Protein of unknown function (DUF796); Region: DUF796; cl01226 290339011903 putative transporter; Provisional; Region: PRK11462 290339011904 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 290339011905 putative alpha-glucosidase; Provisional; Region: PRK10658 290339011906 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 290339011907 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 290339011908 active site 290339011909 homotrimer interface [polypeptide binding]; other site 290339011910 catalytic site [active] 290339011911 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 290339011912 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 290339011913 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290339011914 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339011915 homodimer interface [polypeptide binding]; other site 290339011916 catalytic residue [active] 290339011917 alpha-amylase; Reviewed; Region: malS; PRK09505 290339011918 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 290339011919 active site 290339011920 catalytic site [active] 290339011921 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 290339011922 hypothetical protein; Provisional; Region: PRK10356 290339011923 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 290339011924 putative dimerization interface [polypeptide binding]; other site 290339011925 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290339011926 putative ligand binding site [chemical binding]; other site 290339011927 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290339011928 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 290339011929 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290339011930 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290339011931 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290339011932 TM-ABC transporter signature motif; other site 290339011933 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 290339011934 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290339011935 Walker A/P-loop; other site 290339011936 ATP binding site [chemical binding]; other site 290339011937 Q-loop/lid; other site 290339011938 ABC transporter signature motif; other site 290339011939 Walker B; other site 290339011940 D-loop; other site 290339011941 H-loop/switch region; other site 290339011942 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 290339011943 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 290339011944 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 290339011945 putative ligand binding site [chemical binding]; other site 290339011946 xylose isomerase; Provisional; Region: PRK05474 290339011947 xylose isomerase; Region: xylose_isom_A; TIGR02630 290339011948 xylulokinase; Provisional; Region: PRK15027 290339011949 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 290339011950 N- and C-terminal domain interface [polypeptide binding]; other site 290339011951 active site 290339011952 MgATP binding site [chemical binding]; other site 290339011953 catalytic site [active] 290339011954 metal binding site [ion binding]; metal-binding site 290339011955 xylulose binding site [chemical binding]; other site 290339011956 homodimer interface [polypeptide binding]; other site 290339011957 Isochorismatase family; Region: Isochorismatase; pfam00857 290339011958 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 290339011959 catalytic triad [active] 290339011960 conserved cis-peptide bond; other site 290339011961 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 290339011962 conserved cys residue [active] 290339011963 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290339011964 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 290339011965 Acyltransferase family; Region: Acyl_transf_3; pfam01757 290339011966 YsaB-like lipoprotein; Region: YsaB; pfam13983 290339011967 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 290339011968 dimer interface [polypeptide binding]; other site 290339011969 motif 1; other site 290339011970 active site 290339011971 motif 2; other site 290339011972 motif 3; other site 290339011973 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 290339011974 DALR anticodon binding domain; Region: DALR_1; pfam05746 290339011975 Predicted transcriptional regulator [Transcription]; Region: COG2944 290339011976 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290339011977 salt bridge; other site 290339011978 non-specific DNA binding site [nucleotide binding]; other site 290339011979 sequence-specific DNA binding site [nucleotide binding]; other site 290339011980 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 290339011981 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 290339011982 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 290339011983 dimerization interface [polypeptide binding]; other site 290339011984 ligand binding site [chemical binding]; other site 290339011985 NADP binding site [chemical binding]; other site 290339011986 catalytic site [active] 290339011987 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339011988 D-galactonate transporter; Region: 2A0114; TIGR00893 290339011989 putative substrate translocation pore; other site 290339011990 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290339011991 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 290339011992 substrate binding site [chemical binding]; other site 290339011993 ATP binding site [chemical binding]; other site 290339011994 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 290339011995 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290339011996 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290339011997 DNA binding site [nucleotide binding] 290339011998 domain linker motif; other site 290339011999 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 290339012000 putative dimerization interface [polypeptide binding]; other site 290339012001 putative ligand binding site [chemical binding]; other site 290339012002 zinc/cadmium-binding protein; Provisional; Region: PRK10306 290339012003 putative outer membrane lipoprotein; Provisional; Region: PRK10510 290339012004 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 290339012005 ligand binding site [chemical binding]; other site 290339012006 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 290339012007 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 290339012008 molybdopterin cofactor binding site [chemical binding]; other site 290339012009 substrate binding site [chemical binding]; other site 290339012010 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 290339012011 molybdopterin cofactor binding site; other site 290339012012 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 290339012013 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290339012014 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 290339012015 Coenzyme A binding pocket [chemical binding]; other site 290339012016 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 290339012017 Autotransporter beta-domain; Region: Autotransporter; cl17461 290339012018 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 290339012019 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339012020 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 290339012021 phosphoethanolamine transferase; Provisional; Region: PRK11560 290339012022 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 290339012023 Sulfatase; Region: Sulfatase; pfam00884 290339012024 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 290339012025 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 290339012026 peptide binding site [polypeptide binding]; other site 290339012027 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 290339012028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339012029 dimer interface [polypeptide binding]; other site 290339012030 conserved gate region; other site 290339012031 putative PBP binding loops; other site 290339012032 ABC-ATPase subunit interface; other site 290339012033 dipeptide transporter; Provisional; Region: PRK10913 290339012034 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 290339012035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339012036 dimer interface [polypeptide binding]; other site 290339012037 conserved gate region; other site 290339012038 putative PBP binding loops; other site 290339012039 ABC-ATPase subunit interface; other site 290339012040 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 290339012041 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290339012042 Walker A/P-loop; other site 290339012043 ATP binding site [chemical binding]; other site 290339012044 Q-loop/lid; other site 290339012045 ABC transporter signature motif; other site 290339012046 Walker B; other site 290339012047 D-loop; other site 290339012048 H-loop/switch region; other site 290339012049 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 290339012050 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 290339012051 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290339012052 Walker A/P-loop; other site 290339012053 ATP binding site [chemical binding]; other site 290339012054 Q-loop/lid; other site 290339012055 ABC transporter signature motif; other site 290339012056 Walker B; other site 290339012057 D-loop; other site 290339012058 H-loop/switch region; other site 290339012059 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290339012060 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 290339012061 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 290339012062 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 290339012063 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 290339012064 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 290339012065 YhjQ protein; Region: YhjQ; pfam06564 290339012066 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 290339012067 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 290339012068 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 290339012069 DXD motif; other site 290339012070 PilZ domain; Region: PilZ; pfam07238 290339012071 cellulose synthase regulator protein; Provisional; Region: PRK11114 290339012072 endo-1,4-D-glucanase; Provisional; Region: PRK11097 290339012073 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 290339012074 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290339012075 TPR motif; other site 290339012076 binding surface 290339012077 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 290339012078 putative diguanylate cyclase; Provisional; Region: PRK13561 290339012079 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 290339012080 dimerization interface [polypeptide binding]; other site 290339012081 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290339012082 metal binding site [ion binding]; metal-binding site 290339012083 active site 290339012084 I-site; other site 290339012085 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290339012086 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 290339012087 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 290339012088 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 290339012089 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 290339012090 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290339012091 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 290339012092 substrate binding site [chemical binding]; other site 290339012093 ATP binding site [chemical binding]; other site 290339012094 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290339012095 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 290339012096 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 290339012097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339012098 metabolite-proton symporter; Region: 2A0106; TIGR00883 290339012099 putative substrate translocation pore; other site 290339012100 inner membrane protein YhjD; Region: TIGR00766 290339012101 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290339012102 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339012103 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 290339012104 putative effector binding pocket; other site 290339012105 putative dimerization interface [polypeptide binding]; other site 290339012106 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 290339012107 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290339012108 NAD(P) binding site [chemical binding]; other site 290339012109 active site 290339012110 hypothetical protein; Provisional; Region: PRK10053 290339012111 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 290339012112 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 290339012113 glutathione reductase; Validated; Region: PRK06116 290339012114 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290339012115 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290339012116 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 290339012117 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 290339012118 oligopeptidase A; Provisional; Region: PRK10911 290339012119 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 290339012120 active site 290339012121 Zn binding site [ion binding]; other site 290339012122 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290339012123 S-adenosylmethionine binding site [chemical binding]; other site 290339012124 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290339012125 Ligand Binding Site [chemical binding]; other site 290339012126 universal stress protein UspB; Provisional; Region: PRK04960 290339012127 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 290339012128 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 290339012129 Predicted flavoproteins [General function prediction only]; Region: COG2081 290339012130 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290339012131 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 290339012132 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 290339012133 AAA ATPase domain; Region: AAA_15; pfam13175 290339012134 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 290339012135 active site 290339012136 metal binding site [ion binding]; metal-binding site 290339012137 Domain of unknown function (DUF305); Region: DUF305; cl17794 290339012138 sensor kinase CusS; Provisional; Region: PRK09835 290339012139 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290339012140 dimerization interface [polypeptide binding]; other site 290339012141 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290339012142 dimer interface [polypeptide binding]; other site 290339012143 phosphorylation site [posttranslational modification] 290339012144 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290339012145 ATP binding site [chemical binding]; other site 290339012146 Mg2+ binding site [ion binding]; other site 290339012147 G-X-G motif; other site 290339012148 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 290339012149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290339012150 active site 290339012151 phosphorylation site [posttranslational modification] 290339012152 intermolecular recognition site; other site 290339012153 dimerization interface [polypeptide binding]; other site 290339012154 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290339012155 DNA binding site [nucleotide binding] 290339012156 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 290339012157 periplasmic copper-binding protein; Provisional; Region: PRK09838 290339012158 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 290339012159 HlyD family secretion protein; Region: HlyD_3; pfam13437 290339012160 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 290339012161 Protein of unknown function, DUF; Region: DUF411; cl01142 290339012162 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 290339012163 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290339012164 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290339012165 motif II; other site 290339012166 Protein of unknown function (DUF2933); Region: DUF2933; pfam11666 290339012167 Peptidase family M23; Region: Peptidase_M23; pfam01551 290339012168 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 290339012169 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 290339012170 Multicopper oxidase; Region: Cu-oxidase; pfam00394 290339012171 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 290339012172 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 290339012173 CopC domain; Region: CopC; pfam04234 290339012174 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 290339012175 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 290339012176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290339012177 active site 290339012178 phosphorylation site [posttranslational modification] 290339012179 intermolecular recognition site; other site 290339012180 dimerization interface [polypeptide binding]; other site 290339012181 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290339012182 DNA binding site [nucleotide binding] 290339012183 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 290339012184 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290339012185 dimerization interface [polypeptide binding]; other site 290339012186 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290339012187 dimer interface [polypeptide binding]; other site 290339012188 phosphorylation site [posttranslational modification] 290339012189 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290339012190 ATP binding site [chemical binding]; other site 290339012191 Mg2+ binding site [ion binding]; other site 290339012192 G-X-G motif; other site 290339012193 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 290339012194 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 290339012195 NlpC/P60 family; Region: NLPC_P60; pfam00877 290339012196 Domain of unknown function DUF20; Region: UPF0118; pfam01594 290339012197 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 290339012198 major facilitator superfamily transporter; Provisional; Region: PRK05122 290339012199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339012200 putative substrate translocation pore; other site 290339012201 hypothetical protein; Provisional; Region: PRK11615 290339012202 hypothetical protein; Provisional; Region: PRK11212 290339012203 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 290339012204 CPxP motif; other site 290339012205 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 290339012206 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 290339012207 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 290339012208 DctM-like transporters; Region: DctM; pfam06808 290339012209 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 290339012210 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 290339012211 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 290339012212 metal-binding site [ion binding] 290339012213 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290339012214 Predicted membrane protein [Function unknown]; Region: COG3714 290339012215 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 290339012216 hypothetical protein; Provisional; Region: PRK10910 290339012217 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 290339012218 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290339012219 S-adenosylmethionine binding site [chemical binding]; other site 290339012220 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290339012221 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 290339012222 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 290339012223 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 290339012224 P loop; other site 290339012225 GTP binding site [chemical binding]; other site 290339012226 cell division protein FtsE; Provisional; Region: PRK10908 290339012227 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290339012228 Walker A/P-loop; other site 290339012229 ATP binding site [chemical binding]; other site 290339012230 Q-loop/lid; other site 290339012231 ABC transporter signature motif; other site 290339012232 Walker B; other site 290339012233 D-loop; other site 290339012234 H-loop/switch region; other site 290339012235 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 290339012236 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 290339012237 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 290339012238 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290339012239 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290339012240 DNA binding residues [nucleotide binding] 290339012241 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 290339012242 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290339012243 DNA-binding site [nucleotide binding]; DNA binding site 290339012244 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290339012245 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339012246 homodimer interface [polypeptide binding]; other site 290339012247 catalytic residue [active] 290339012248 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 290339012249 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 290339012250 inhibitor-cofactor binding pocket; inhibition site 290339012251 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339012252 catalytic residue [active] 290339012253 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 290339012254 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 290339012255 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 290339012256 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 290339012257 dimerization interface [polypeptide binding]; other site 290339012258 ligand binding site [chemical binding]; other site 290339012259 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 290339012260 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 290339012261 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290339012262 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 290339012263 TM-ABC transporter signature motif; other site 290339012264 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 290339012265 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 290339012266 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 290339012267 TM-ABC transporter signature motif; other site 290339012268 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 290339012269 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 290339012270 Walker A/P-loop; other site 290339012271 ATP binding site [chemical binding]; other site 290339012272 Q-loop/lid; other site 290339012273 ABC transporter signature motif; other site 290339012274 Walker B; other site 290339012275 D-loop; other site 290339012276 H-loop/switch region; other site 290339012277 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 290339012278 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 290339012279 Walker A/P-loop; other site 290339012280 ATP binding site [chemical binding]; other site 290339012281 Q-loop/lid; other site 290339012282 ABC transporter signature motif; other site 290339012283 Walker B; other site 290339012284 D-loop; other site 290339012285 H-loop/switch region; other site 290339012286 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 290339012287 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 290339012288 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 290339012289 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290339012290 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339012291 dimer interface [polypeptide binding]; other site 290339012292 conserved gate region; other site 290339012293 putative PBP binding loops; other site 290339012294 ABC-ATPase subunit interface; other site 290339012295 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290339012296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290339012297 dimer interface [polypeptide binding]; other site 290339012298 conserved gate region; other site 290339012299 putative PBP binding loops; other site 290339012300 ABC-ATPase subunit interface; other site 290339012301 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 290339012302 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 290339012303 Walker A/P-loop; other site 290339012304 ATP binding site [chemical binding]; other site 290339012305 Q-loop/lid; other site 290339012306 ABC transporter signature motif; other site 290339012307 Walker B; other site 290339012308 D-loop; other site 290339012309 H-loop/switch region; other site 290339012310 TOBE domain; Region: TOBE_2; pfam08402 290339012311 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 290339012312 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 290339012313 putative active site [active] 290339012314 catalytic site [active] 290339012315 putative metal binding site [ion binding]; other site 290339012316 hypothetical protein; Provisional; Region: PRK10350 290339012317 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 290339012318 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 290339012319 putative acetyltransferase YhhY; Provisional; Region: PRK10140 290339012320 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290339012321 Coenzyme A binding pocket [chemical binding]; other site 290339012322 putative oxidoreductase; Provisional; Region: PRK10206 290339012323 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290339012324 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290339012325 Pirin-related protein [General function prediction only]; Region: COG1741 290339012326 Pirin; Region: Pirin; pfam02678 290339012327 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 290339012328 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290339012329 DNA binding site [nucleotide binding] 290339012330 domain linker motif; other site 290339012331 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 290339012332 putative ligand binding site [chemical binding]; other site 290339012333 putative dimerization interface [polypeptide binding]; other site 290339012334 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 290339012335 ATP-binding site [chemical binding]; other site 290339012336 Gluconate-6-phosphate binding site [chemical binding]; other site 290339012337 low affinity gluconate transporter; Provisional; Region: PRK10472 290339012338 gluconate transporter; Region: gntP; TIGR00791 290339012339 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 290339012340 Fic/DOC family; Region: Fic; pfam02661 290339012341 putative antibiotic transporter; Provisional; Region: PRK10739 290339012342 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 290339012343 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 290339012344 glycogen branching enzyme; Provisional; Region: PRK05402 290339012345 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 290339012346 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 290339012347 active site 290339012348 catalytic site [active] 290339012349 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 290339012350 glycogen debranching enzyme; Provisional; Region: PRK03705 290339012351 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 290339012352 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 290339012353 active site 290339012354 catalytic site [active] 290339012355 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 290339012356 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 290339012357 ligand binding site; other site 290339012358 oligomer interface; other site 290339012359 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 290339012360 dimer interface [polypeptide binding]; other site 290339012361 N-terminal domain interface [polypeptide binding]; other site 290339012362 sulfate 1 binding site; other site 290339012363 glycogen synthase; Provisional; Region: glgA; PRK00654 290339012364 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 290339012365 ADP-binding pocket [chemical binding]; other site 290339012366 homodimer interface [polypeptide binding]; other site 290339012367 glycogen phosphorylase; Provisional; Region: PRK14986 290339012368 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 290339012369 homodimer interface [polypeptide binding]; other site 290339012370 active site pocket [active] 290339012371 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 290339012372 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290339012373 metal binding site [ion binding]; metal-binding site 290339012374 active site 290339012375 I-site; other site 290339012376 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 290339012377 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 290339012378 active site residue [active] 290339012379 intramembrane serine protease GlpG; Provisional; Region: PRK10907 290339012380 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 290339012381 Rhomboid family; Region: Rhomboid; cl11446 290339012382 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 290339012383 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 290339012384 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 290339012385 transcriptional regulator MalT; Provisional; Region: PRK04841 290339012386 AAA ATPase domain; Region: AAA_16; pfam13191 290339012387 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290339012388 DNA binding residues [nucleotide binding] 290339012389 dimerization interface [polypeptide binding]; other site 290339012390 maltodextrin phosphorylase; Provisional; Region: PRK14985 290339012391 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 290339012392 active site pocket [active] 290339012393 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 290339012394 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 290339012395 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 290339012396 DNA-binding site [nucleotide binding]; DNA binding site 290339012397 RNA-binding motif; other site 290339012398 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 290339012399 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 290339012400 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 290339012401 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290339012402 active site 290339012403 carboxylesterase BioH; Provisional; Region: PRK10349 290339012404 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 290339012405 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 290339012406 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 290339012407 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 290339012408 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 290339012409 G1 box; other site 290339012410 GTP/Mg2+ binding site [chemical binding]; other site 290339012411 Switch I region; other site 290339012412 G2 box; other site 290339012413 G3 box; other site 290339012414 Switch II region; other site 290339012415 G4 box; other site 290339012416 G5 box; other site 290339012417 Nucleoside recognition; Region: Gate; pfam07670 290339012418 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 290339012419 Nucleoside recognition; Region: Gate; pfam07670 290339012420 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 290339012421 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 290339012422 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 290339012423 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 290339012424 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 290339012425 RNA binding site [nucleotide binding]; other site 290339012426 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 290339012427 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 290339012428 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 290339012429 osmolarity response regulator; Provisional; Region: ompR; PRK09468 290339012430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290339012431 active site 290339012432 phosphorylation site [posttranslational modification] 290339012433 intermolecular recognition site; other site 290339012434 dimerization interface [polypeptide binding]; other site 290339012435 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290339012436 DNA binding site [nucleotide binding] 290339012437 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 290339012438 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290339012439 dimerization interface [polypeptide binding]; other site 290339012440 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290339012441 dimer interface [polypeptide binding]; other site 290339012442 phosphorylation site [posttranslational modification] 290339012443 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290339012444 ATP binding site [chemical binding]; other site 290339012445 G-X-G motif; other site 290339012446 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 290339012447 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 290339012448 active site 290339012449 substrate-binding site [chemical binding]; other site 290339012450 metal-binding site [ion binding] 290339012451 ATP binding site [chemical binding]; other site 290339012452 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 290339012453 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 290339012454 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 290339012455 dimerization interface [polypeptide binding]; other site 290339012456 domain crossover interface; other site 290339012457 redox-dependent activation switch; other site 290339012458 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 290339012459 RNA binding surface [nucleotide binding]; other site 290339012460 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 290339012461 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290339012462 motif II; other site 290339012463 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 290339012464 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 290339012465 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 290339012466 ADP-ribose binding site [chemical binding]; other site 290339012467 dimer interface [polypeptide binding]; other site 290339012468 active site 290339012469 nudix motif; other site 290339012470 metal binding site [ion binding]; metal-binding site 290339012471 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 290339012472 Transglycosylase; Region: Transgly; pfam00912 290339012473 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 290339012474 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 290339012475 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 290339012476 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 290339012477 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 290339012478 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 290339012479 shikimate kinase; Reviewed; Region: aroK; PRK00131 290339012480 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 290339012481 ADP binding site [chemical binding]; other site 290339012482 magnesium binding site [ion binding]; other site 290339012483 putative shikimate binding site; other site 290339012484 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 290339012485 active site 290339012486 dimer interface [polypeptide binding]; other site 290339012487 metal binding site [ion binding]; metal-binding site 290339012488 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 290339012489 cell division protein DamX; Validated; Region: PRK10905 290339012490 DNA adenine methylase; Provisional; Region: PRK10904 290339012491 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 290339012492 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 290339012493 substrate binding site [chemical binding]; other site 290339012494 hexamer interface [polypeptide binding]; other site 290339012495 metal binding site [ion binding]; metal-binding site 290339012496 phosphoglycolate phosphatase; Provisional; Region: PRK13222 290339012497 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 290339012498 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290339012499 motif II; other site 290339012500 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 290339012501 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 290339012502 active site 290339012503 HIGH motif; other site 290339012504 dimer interface [polypeptide binding]; other site 290339012505 KMSKS motif; other site 290339012506 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 290339012507 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 290339012508 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290339012509 DNA-binding site [nucleotide binding]; DNA binding site 290339012510 UTRA domain; Region: UTRA; pfam07702 290339012511 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 290339012512 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290339012513 substrate binding site [chemical binding]; other site 290339012514 ATP binding site [chemical binding]; other site 290339012515 fructoselysine 3-epimerase; Provisional; Region: PRK09856 290339012516 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 290339012517 AP (apurinic/apyrimidinic) site pocket; other site 290339012518 DNA interaction; other site 290339012519 Metal-binding active site; metal-binding site 290339012520 fructoselysine-6-P-deglycase; Provisional; Region: frlB; PRK11382 290339012521 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 290339012522 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 290339012523 dimer interface [polypeptide binding]; other site 290339012524 active site 290339012525 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 290339012526 hypothetical protein; Provisional; Region: PHA02764 290339012527 siroheme synthase; Provisional; Region: cysG; PRK10637 290339012528 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 290339012529 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 290339012530 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 290339012531 active site 290339012532 SAM binding site [chemical binding]; other site 290339012533 homodimer interface [polypeptide binding]; other site 290339012534 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 290339012535 nitrite reductase subunit NirD; Provisional; Region: PRK14989 290339012536 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290339012537 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 290339012538 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 290339012539 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 290339012540 putative transporter; Provisional; Region: PRK03699 290339012541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339012542 putative substrate translocation pore; other site 290339012543 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 290339012544 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 290339012545 substrate binding site [chemical binding]; other site 290339012546 Protein of unknown function (DUF2559); Region: DUF2559; pfam10832 290339012547 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 290339012548 cell filamentation protein Fic; Provisional; Region: PRK10347 290339012549 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 290339012550 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 290339012551 glutamine binding [chemical binding]; other site 290339012552 catalytic triad [active] 290339012553 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 290339012554 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 290339012555 inhibitor-cofactor binding pocket; inhibition site 290339012556 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339012557 catalytic residue [active] 290339012558 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 290339012559 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 290339012560 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 290339012561 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 290339012562 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 290339012563 ligand binding site [chemical binding]; other site 290339012564 flexible hinge region; other site 290339012565 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 290339012566 putative switch regulator; other site 290339012567 non-specific DNA interactions [nucleotide binding]; other site 290339012568 DNA binding site [nucleotide binding] 290339012569 sequence specific DNA binding site [nucleotide binding]; other site 290339012570 putative cAMP binding site [chemical binding]; other site 290339012571 hypothetical protein; Provisional; Region: PRK10738 290339012572 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 290339012573 active site 290339012574 hypothetical protein; Provisional; Region: PRK04966 290339012575 putative hydrolase; Provisional; Region: PRK10985 290339012576 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 290339012577 nudix motif; other site 290339012578 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 290339012579 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 290339012580 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290339012581 active site 290339012582 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 290339012583 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 290339012584 active site 290339012585 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 290339012586 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 290339012587 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290339012588 Walker A/P-loop; other site 290339012589 ATP binding site [chemical binding]; other site 290339012590 Q-loop/lid; other site 290339012591 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290339012592 ABC transporter signature motif; other site 290339012593 Walker B; other site 290339012594 D-loop; other site 290339012595 ABC transporter; Region: ABC_tran_2; pfam12848 290339012596 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290339012597 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 290339012598 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 290339012599 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 290339012600 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 290339012601 TrkA-N domain; Region: TrkA_N; pfam02254 290339012602 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 290339012603 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 290339012604 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 290339012605 SlyX; Region: SlyX; pfam04102 290339012606 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 290339012607 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 290339012608 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 290339012609 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 290339012610 YheO-like PAS domain; Region: PAS_6; pfam08348 290339012611 HTH domain; Region: HTH_22; pfam13309 290339012612 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 290339012613 sulfur relay protein TusC; Validated; Region: PRK00211 290339012614 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 290339012615 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 290339012616 S17 interaction site [polypeptide binding]; other site 290339012617 S8 interaction site; other site 290339012618 16S rRNA interaction site [nucleotide binding]; other site 290339012619 streptomycin interaction site [chemical binding]; other site 290339012620 23S rRNA interaction site [nucleotide binding]; other site 290339012621 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 290339012622 30S ribosomal protein S7; Validated; Region: PRK05302 290339012623 elongation factor G; Reviewed; Region: PRK00007 290339012624 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 290339012625 G1 box; other site 290339012626 putative GEF interaction site [polypeptide binding]; other site 290339012627 GTP/Mg2+ binding site [chemical binding]; other site 290339012628 Switch I region; other site 290339012629 G2 box; other site 290339012630 G3 box; other site 290339012631 Switch II region; other site 290339012632 G4 box; other site 290339012633 G5 box; other site 290339012634 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 290339012635 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 290339012636 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 290339012637 elongation factor Tu; Reviewed; Region: PRK00049 290339012638 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 290339012639 G1 box; other site 290339012640 GEF interaction site [polypeptide binding]; other site 290339012641 GTP/Mg2+ binding site [chemical binding]; other site 290339012642 Switch I region; other site 290339012643 G2 box; other site 290339012644 G3 box; other site 290339012645 Switch II region; other site 290339012646 G4 box; other site 290339012647 G5 box; other site 290339012648 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 290339012649 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 290339012650 Antibiotic Binding Site [chemical binding]; other site 290339012651 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 290339012652 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 290339012653 heme binding site [chemical binding]; other site 290339012654 ferroxidase pore; other site 290339012655 ferroxidase diiron center [ion binding]; other site 290339012656 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 290339012657 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 290339012658 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 290339012659 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 290339012660 Staphylococcal nuclease homologues; Region: SNc; smart00318 290339012661 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 290339012662 Catalytic site; other site 290339012663 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 290339012664 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 290339012665 P-loop; other site 290339012666 Magnesium ion binding site [ion binding]; other site 290339012667 Restriction endonuclease NotI; Region: NotI; pfam12183 290339012668 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 290339012669 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 290339012670 cofactor binding site; other site 290339012671 DNA binding site [nucleotide binding] 290339012672 substrate interaction site [chemical binding]; other site 290339012673 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 290339012674 multiple promoter invertase; Provisional; Region: mpi; PRK13413 290339012675 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 290339012676 catalytic residues [active] 290339012677 catalytic nucleophile [active] 290339012678 Presynaptic Site I dimer interface [polypeptide binding]; other site 290339012679 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 290339012680 Synaptic Flat tetramer interface [polypeptide binding]; other site 290339012681 Synaptic Site I dimer interface [polypeptide binding]; other site 290339012682 DNA binding site [nucleotide binding] 290339012683 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 290339012684 DNA-binding interface [nucleotide binding]; DNA binding site 290339012685 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 290339012686 Uncharacterized conserved protein [Function unknown]; Region: COG2361 290339012687 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 290339012688 active site 290339012689 NTP binding site [chemical binding]; other site 290339012690 metal binding triad [ion binding]; metal-binding site 290339012691 antibiotic binding site [chemical binding]; other site 290339012692 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 290339012693 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 290339012694 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 290339012695 active site 290339012696 IncFII RepA protein family; Region: IncFII_repA; cl11495 290339012697 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 290339012698 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290339012699 non-specific DNA binding site [nucleotide binding]; other site 290339012700 salt bridge; other site 290339012701 sequence-specific DNA binding site [nucleotide binding]; other site 290339012702 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), AnFA1; Region: NGN_SP_AnfA1; cd09894 290339012703 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 290339012704 N-acetyl-D-glucosamine binding site [chemical binding]; other site 290339012705 catalytic residue [active] 290339012706 TrbC/VIRB2 family; Region: TrbC; cl01583 290339012707 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 290339012708 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 290339012709 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 290339012710 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 290339012711 Type IV secretion system proteins; Region: T4SS; pfam07996 290339012712 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 290339012713 VirB8 protein; Region: VirB8; pfam04335 290339012714 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 290339012715 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 290339012716 VirB7 interaction site; other site 290339012717 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 290339012718 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 290339012719 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 290339012720 Walker A motif; other site 290339012721 hexamer interface [polypeptide binding]; other site 290339012722 ATP binding site [chemical binding]; other site 290339012723 Walker B motif; other site 290339012724 Cag pathogenicity island protein Cag12; Region: Cag12; pfam13117 290339012725 TrbM; Region: TrbM; pfam07424 290339012726 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290339012727 catalytic core [active] 290339012728 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 290339012729 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 290339012730 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 290339012731 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 290339012732 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 290339012733 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 290339012734 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290339012735 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339012736 putative substrate translocation pore; other site 290339012737 outer membrane protease; Reviewed; Region: PRK10993 290339012738 HTH domain; Region: HTH_11; pfam08279 290339012739 Predicted transcriptional regulator [Transcription]; Region: COG2378 290339012740 WYL domain; Region: WYL; pfam13280 290339012741 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 290339012742 putative dimer interface [polypeptide binding]; other site 290339012743 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290339012744 antimicrobial resistance protein Mig-14; Provisional; Region: PRK15312 290339012745 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 290339012746 MltA-interacting protein MipA; Region: MipA; cl01504 290339012747 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290339012748 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290339012749 active site 290339012750 phosphorylation site [posttranslational modification] 290339012751 intermolecular recognition site; other site 290339012752 dimerization interface [polypeptide binding]; other site 290339012753 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290339012754 DNA binding site [nucleotide binding] 290339012755 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 290339012756 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 290339012757 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290339012758 dimer interface [polypeptide binding]; other site 290339012759 phosphorylation site [posttranslational modification] 290339012760 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290339012761 ATP binding site [chemical binding]; other site 290339012762 Mg2+ binding site [ion binding]; other site 290339012763 G-X-G motif; other site 290339012764 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 290339012765 HlyD family secretion protein; Region: HlyD_3; pfam13437 290339012766 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 290339012767 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 290339012768 nudix motif; other site 290339012769 DinB family; Region: DinB; cl17821 290339012770 DinB superfamily; Region: DinB_2; pfam12867 290339012771 ABC transporter transmembrane region; Region: ABC_membrane_3; pfam13748 290339012772 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 290339012773 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290339012774 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290339012775 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 290339012776 citrate-proton symporter; Provisional; Region: PRK15075 290339012777 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339012778 putative substrate translocation pore; other site 290339012779 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 290339012780 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290339012781 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290339012782 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 290339012783 putative dimerization interface [polypeptide binding]; other site 290339012784 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290339012785 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290339012786 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 290339012787 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 290339012788 active site 290339012789 metal binding site [ion binding]; metal-binding site 290339012790 hexamer interface [polypeptide binding]; other site 290339012791 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 290339012792 Sensors of blue-light using FAD; Region: BLUF; smart01034 290339012793 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290339012794 transcriptional regulator MirA; Provisional; Region: PRK15043 290339012795 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 290339012796 DNA binding residues [nucleotide binding] 290339012797 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 290339012798 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290339012799 dimerization interface [polypeptide binding]; other site 290339012800 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 290339012801 dimer interface [polypeptide binding]; other site 290339012802 putative CheW interface [polypeptide binding]; other site 290339012803 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290339012804 Coenzyme A binding pocket [chemical binding]; other site 290339012805 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 290339012806 ACT domain-containing protein [General function prediction only]; Region: COG4747 290339012807 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 290339012808 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290339012809 dimerization interface [polypeptide binding]; other site 290339012810 putative DNA binding site [nucleotide binding]; other site 290339012811 putative Zn2+ binding site [ion binding]; other site 290339012812 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 290339012813 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 290339012814 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 290339012815 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 290339012816 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 290339012817 active site turn [active] 290339012818 phosphorylation site [posttranslational modification] 290339012819 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 290339012820 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 290339012821 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 290339012822 metal binding site [ion binding]; metal-binding site 290339012823 substrate binding pocket [chemical binding]; other site 290339012824 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 290339012825 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290339012826 DNA-binding site [nucleotide binding]; DNA binding site 290339012827 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 290339012828 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 290339012829 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 290339012830 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 290339012831 squalene/oxidosqualene cyclases; Region: squalene_cyclas; TIGR01787 290339012832 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 290339012833 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290339012834 metal binding site [ion binding]; metal-binding site 290339012835 active site 290339012836 I-site; other site 290339012837 Protein of unknown function (DUF796); Region: DUF796; pfam05638 290339012838 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 290339012839 dimerization interface [polypeptide binding]; other site 290339012840 Cation transport protein; Region: TrkH; cl17365 290339012841 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 290339012842 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 290339012843 ArsC family; Region: ArsC; pfam03960 290339012844 catalytic residues [active] 290339012845 arsenical pump membrane protein; Provisional; Region: PRK15445 290339012846 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 290339012847 transmembrane helices; other site 290339012848 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290339012849 putative DNA binding site [nucleotide binding]; other site 290339012850 putative Zn2+ binding site [ion binding]; other site 290339012851 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 290339012852 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 290339012853 inhibitor site; inhibition site 290339012854 active site 290339012855 dimer interface [polypeptide binding]; other site 290339012856 catalytic residue [active] 290339012857 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 290339012858 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 290339012859 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290339012860 DNA-binding site [nucleotide binding]; DNA binding site 290339012861 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290339012862 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290339012863 homodimer interface [polypeptide binding]; other site 290339012864 catalytic residue [active] 290339012865 Protein of unknown function (DUF770); Region: DUF770; pfam05591 290339012866 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 290339012867 Protein of unknown function (DUF877); Region: DUF877; pfam05943 290339012868 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 290339012869 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 290339012870 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 290339012871 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 290339012872 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 290339012873 ligand binding site [chemical binding]; other site 290339012874 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 290339012875 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 290339012876 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290339012877 Walker A motif; other site 290339012878 ATP binding site [chemical binding]; other site 290339012879 Walker B motif; other site 290339012880 arginine finger; other site 290339012881 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290339012882 Walker A motif; other site 290339012883 ATP binding site [chemical binding]; other site 290339012884 Walker B motif; other site 290339012885 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 290339012886 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 290339012887 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 290339012888 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 290339012889 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 290339012890 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 290339012891 Peptidase M35-like domain of uncharacterized proteins; Region: M35_like_1; cd11007 290339012892 putative active site [active] 290339012893 putative Zn binding site [ion binding]; other site 290339012894 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 290339012895 PAAR motif; Region: PAAR_motif; pfam05488 290339012896 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 290339012897 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 290339012898 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 290339012899 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 290339012900 dimerization domain [polypeptide binding]; other site 290339012901 dimer interface [polypeptide binding]; other site 290339012902 catalytic residues [active] 290339012903 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 290339012904 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 290339012905 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 290339012906 DsbD alpha interface [polypeptide binding]; other site 290339012907 catalytic residues [active] 290339012908 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 290339012909 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 290339012910 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 290339012911 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 290339012912 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 290339012913 Walker A/P-loop; other site 290339012914 ATP binding site [chemical binding]; other site 290339012915 Q-loop/lid; other site 290339012916 ABC transporter signature motif; other site 290339012917 Walker B; other site 290339012918 D-loop; other site 290339012919 H-loop/switch region; other site 290339012920 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 290339012921 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290339012922 ABC-ATPase subunit interface; other site 290339012923 dimer interface [polypeptide binding]; other site 290339012924 putative PBP binding regions; other site 290339012925 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 290339012926 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 290339012927 intersubunit interface [polypeptide binding]; other site 290339012928 multidrug resistance protein MdtH; Provisional; Region: PRK11646 290339012929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339012930 putative substrate translocation pore; other site 290339012931 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 290339012932 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 290339012933 active site 290339012934 DNA binding site [nucleotide binding] 290339012935 Int/Topo IB signature motif; other site 290339012936 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 290339012937 putative homodimer interface [polypeptide binding]; other site 290339012938 putative active site [active] 290339012939 catalytic site [active] 290339012940 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 290339012941 putative Mg++ binding site [ion binding]; other site 290339012942 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 290339012943 ATP-binding site [chemical binding]; other site 290339012944 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290339012945 C factor cell-cell signaling protein; Provisional; Region: PRK09009 290339012946 NAD(P) binding site [chemical binding]; other site 290339012947 active site 290339012948 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 290339012949 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 290339012950 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 290339012951 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 290339012952 dimer interface [polypeptide binding]; other site 290339012953 putative CheW interface [polypeptide binding]; other site 290339012954 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 290339012955 guanine deaminase; Provisional; Region: PRK09228 290339012956 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 290339012957 active site 290339012958 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 290339012959 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 290339012960 putative C-terminal domain interface [polypeptide binding]; other site 290339012961 putative GSH binding site (G-site) [chemical binding]; other site 290339012962 putative dimer interface [polypeptide binding]; other site 290339012963 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 290339012964 dimer interface [polypeptide binding]; other site 290339012965 N-terminal domain interface [polypeptide binding]; other site 290339012966 substrate binding pocket (H-site) [chemical binding]; other site 290339012967 Cache domain; Region: Cache_1; pfam02743 290339012968 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 290339012969 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 290339012970 dimer interface [polypeptide binding]; other site 290339012971 putative CheW interface [polypeptide binding]; other site 290339012972 AAA ATPase domain; Region: AAA_16; pfam13191 290339012973 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 290339012974 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 290339012975 magnesium-transporting ATPase; Provisional; Region: PRK15122 290339012976 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 290339012977 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290339012978 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 290339012979 Soluble P-type ATPase [General function prediction only]; Region: COG4087 290339012980 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 290339012981 Uncharacterized conserved protein [Function unknown]; Region: COG2850 290339012982 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 290339012983 Putative Ig domain; Region: He_PIG; pfam05345 290339012984 Autotransporter beta-domain; Region: Autotransporter; smart00869 290339012985 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 290339012986 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 290339012987 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 290339012988 active site 290339012989 catalytic site [active] 290339012990 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 290339012991 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 290339012992 active site 290339012993 catalytic site [active] 290339012994 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 290339012995 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 290339012996 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 290339012997 catalytic site [active] 290339012998 active site 290339012999 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 290339013000 HipA N-terminal domain; Region: Couple_hipA; pfam13657 290339013001 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 290339013002 HipA-like N-terminal domain; Region: HipA_N; pfam07805 290339013003 HipA-like C-terminal domain; Region: HipA_C; pfam07804 290339013004 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290339013005 salt bridge; other site 290339013006 non-specific DNA binding site [nucleotide binding]; other site 290339013007 sequence-specific DNA binding site [nucleotide binding]; other site 290339013008 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 290339013009 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 290339013010 FAD binding pocket [chemical binding]; other site 290339013011 FAD binding motif [chemical binding]; other site 290339013012 phosphate binding motif [ion binding]; other site 290339013013 NAD binding pocket [chemical binding]; other site 290339013014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290339013015 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290339013016 putative substrate translocation pore; other site 290339013017 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 290339013018 IucA / IucC family; Region: IucA_IucC; pfam04183 290339013019 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 290339013020 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 290339013021 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 290339013022 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 290339013023 IucA / IucC family; Region: IucA_IucC; pfam04183 290339013024 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 290339013025 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 290339013026 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290339013027 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 290339013028 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 290339013029 N-terminal plug; other site 290339013030 ligand-binding site [chemical binding]; other site 290339013031 ParB-like nuclease domain; Region: ParB; smart00470 290339013032 ParB family; Region: ParB; pfam08775 290339013033 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 290339013034 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 290339013035 P-loop; other site 290339013036 Magnesium ion binding site [ion binding]; other site 290339013037 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 290339013038 Magnesium ion binding site [ion binding]; other site