-- dump date 20140619_053836 -- class Genbank::misc_feature -- table misc_feature_note -- id note 956149000001 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 956149000002 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 956149000003 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 956149000004 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 956149000005 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 956149000006 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 956149000007 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 956149000008 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 956149000009 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 956149000010 protein-rRNA interface [nucleotide binding]; other site 956149000011 putative translocon binding site; other site 956149000012 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 956149000013 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 956149000014 G-X-X-G motif; other site 956149000015 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 956149000016 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 956149000017 23S rRNA interface [nucleotide binding]; other site 956149000018 5S rRNA interface [nucleotide binding]; other site 956149000019 putative antibiotic binding site [chemical binding]; other site 956149000020 L25 interface [polypeptide binding]; other site 956149000021 L27 interface [polypeptide binding]; other site 956149000022 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 956149000023 23S rRNA interface [nucleotide binding]; other site 956149000024 putative translocon interaction site; other site 956149000025 signal recognition particle (SRP54) interaction site; other site 956149000026 L23 interface [polypeptide binding]; other site 956149000027 trigger factor interaction site; other site 956149000028 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 956149000029 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 956149000030 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 956149000031 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 956149000032 RNA binding site [nucleotide binding]; other site 956149000033 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 956149000034 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 956149000035 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 956149000036 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 956149000037 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 956149000038 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 956149000039 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 956149000040 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 956149000041 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 956149000042 23S rRNA interface [nucleotide binding]; other site 956149000043 5S rRNA interface [nucleotide binding]; other site 956149000044 L27 interface [polypeptide binding]; other site 956149000045 L5 interface [polypeptide binding]; other site 956149000046 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 956149000047 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 956149000048 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 956149000049 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 956149000050 23S rRNA binding site [nucleotide binding]; other site 956149000051 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 956149000052 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 956149000053 SecY translocase; Region: SecY; pfam00344 956149000054 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 956149000055 30S ribosomal protein S13; Region: bact_S13; TIGR03631 956149000056 30S ribosomal protein S11; Validated; Region: PRK05309 956149000057 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 956149000058 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 956149000059 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 956149000060 RNA binding surface [nucleotide binding]; other site 956149000061 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 956149000062 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 956149000063 alphaNTD homodimer interface [polypeptide binding]; other site 956149000064 alphaNTD - beta interaction site [polypeptide binding]; other site 956149000065 alphaNTD - beta' interaction site [polypeptide binding]; other site 956149000066 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 956149000067 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 956149000068 hypothetical protein; Provisional; Region: PRK10203 956149000069 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 956149000070 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 956149000071 DNA binding residues [nucleotide binding] 956149000072 dimer interface [polypeptide binding]; other site 956149000073 metal binding site [ion binding]; metal-binding site 956149000074 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 956149000075 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 956149000076 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 956149000077 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 956149000078 TrkA-N domain; Region: TrkA_N; pfam02254 956149000079 TrkA-C domain; Region: TrkA_C; pfam02080 956149000080 TrkA-N domain; Region: TrkA_N; pfam02254 956149000081 TrkA-C domain; Region: TrkA_C; pfam02080 956149000082 16S rRNA methyltransferase B; Provisional; Region: PRK10901 956149000083 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 956149000084 putative RNA binding site [nucleotide binding]; other site 956149000085 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 956149000086 S-adenosylmethionine binding site [chemical binding]; other site 956149000087 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 956149000088 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 956149000089 putative active site [active] 956149000090 substrate binding site [chemical binding]; other site 956149000091 putative cosubstrate binding site; other site 956149000092 catalytic site [active] 956149000093 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 956149000094 substrate binding site [chemical binding]; other site 956149000095 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 956149000096 active site 956149000097 catalytic residues [active] 956149000098 metal binding site [ion binding]; metal-binding site 956149000099 hypothetical protein; Provisional; Region: PRK10736 956149000100 DNA protecting protein DprA; Region: dprA; TIGR00732 956149000101 hypothetical protein; Validated; Region: PRK03430 956149000102 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 956149000103 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 956149000104 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 956149000105 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 956149000106 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 956149000107 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 956149000108 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 956149000109 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 956149000110 shikimate binding site; other site 956149000111 NAD(P) binding site [chemical binding]; other site 956149000112 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 956149000113 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 956149000114 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 956149000115 trimer interface [polypeptide binding]; other site 956149000116 putative metal binding site [ion binding]; other site 956149000117 homoserine O-succinyltransferase; Provisional; Region: PRK05368 956149000118 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 956149000119 proposed active site lysine [active] 956149000120 conserved cys residue [active] 956149000121 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 956149000122 malate synthase A; Region: malate_syn_A; TIGR01344 956149000123 active site 956149000124 isocitrate lyase; Provisional; Region: PRK15063 956149000125 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 956149000126 tetramer interface [polypeptide binding]; other site 956149000127 active site 956149000128 Mg2+/Mn2+ binding site [ion binding]; other site 956149000129 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 956149000130 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 956149000131 transcriptional repressor IclR; Provisional; Region: PRK11569 956149000132 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 956149000133 Bacterial transcriptional regulator; Region: IclR; pfam01614 956149000134 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 956149000135 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 956149000136 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 956149000137 substrate binding pocket [chemical binding]; other site 956149000138 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 956149000139 B12 binding site [chemical binding]; other site 956149000140 cobalt ligand [ion binding]; other site 956149000141 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 956149000142 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 956149000143 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 956149000144 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 956149000145 probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684 956149000146 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 956149000147 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 956149000148 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 956149000149 non-specific DNA binding site [nucleotide binding]; other site 956149000150 salt bridge; other site 956149000151 sequence-specific DNA binding site [nucleotide binding]; other site 956149000152 hypothetical protein; Provisional; Region: PRK10515 956149000153 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 956149000154 Sodium Bile acid symporter family; Region: SBF; pfam01758 956149000155 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 956149000156 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 956149000157 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 956149000158 Walker A motif; other site 956149000159 ATP binding site [chemical binding]; other site 956149000160 Walker B motif; other site 956149000161 arginine finger; other site 956149000162 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 956149000163 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 956149000164 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 956149000165 hypothetical protein; Reviewed; Region: PRK09588 956149000166 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 956149000167 aspartate kinase III; Validated; Region: PRK09084 956149000168 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 956149000169 nucleotide binding site [chemical binding]; other site 956149000170 substrate binding site [chemical binding]; other site 956149000171 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 956149000172 lysine allosteric regulatory site; other site 956149000173 dimer interface [polypeptide binding]; other site 956149000174 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 956149000175 dimer interface [polypeptide binding]; other site 956149000176 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 956149000177 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 956149000178 active site 956149000179 dimer interface [polypeptide binding]; other site 956149000180 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 956149000181 dimer interface [polypeptide binding]; other site 956149000182 active site 956149000183 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 956149000184 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 956149000185 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 956149000186 potential frameshift: common BLAST hit: gi|389839396|ref|YP_006341480.1| acyltransferase 956149000187 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 956149000188 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149000189 dimer interface [polypeptide binding]; other site 956149000190 conserved gate region; other site 956149000191 putative PBP binding loops; other site 956149000192 ABC-ATPase subunit interface; other site 956149000193 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149000194 dimer interface [polypeptide binding]; other site 956149000195 conserved gate region; other site 956149000196 ABC-ATPase subunit interface; other site 956149000197 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 956149000198 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 956149000199 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 956149000200 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 956149000201 Walker A/P-loop; other site 956149000202 ATP binding site [chemical binding]; other site 956149000203 Q-loop/lid; other site 956149000204 ABC transporter signature motif; other site 956149000205 Walker B; other site 956149000206 D-loop; other site 956149000207 H-loop/switch region; other site 956149000208 TOBE domain; Region: TOBE_2; pfam08402 956149000209 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 956149000210 trimer interface; other site 956149000211 sugar binding site [chemical binding]; other site 956149000212 maltose regulon periplasmic protein; Provisional; Region: PRK10564 956149000213 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 956149000214 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 956149000215 UbiA prenyltransferase family; Region: UbiA; pfam01040 956149000216 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 956149000217 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 956149000218 putative acyl-acceptor binding pocket; other site 956149000219 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 956149000220 LexA repressor; Validated; Region: PRK00215 956149000221 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 956149000222 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 956149000223 Catalytic site [active] 956149000224 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 956149000225 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 956149000226 hypothetical protein; Provisional; Region: PRK10428 956149000227 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 956149000228 metal binding site 2 [ion binding]; metal-binding site 956149000229 putative DNA binding helix; other site 956149000230 metal binding site 1 [ion binding]; metal-binding site 956149000231 dimer interface [polypeptide binding]; other site 956149000232 structural Zn2+ binding site [ion binding]; other site 956149000233 Cupin domain; Region: Cupin_2; cl17218 956149000234 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 956149000235 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 956149000236 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 956149000237 FMN binding site [chemical binding]; other site 956149000238 active site 956149000239 catalytic residues [active] 956149000240 substrate binding site [chemical binding]; other site 956149000241 phage shock protein G; Reviewed; Region: pspG; PRK09459 956149000242 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 956149000243 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 956149000244 NADP binding site [chemical binding]; other site 956149000245 dimer interface [polypeptide binding]; other site 956149000246 replicative DNA helicase; Provisional; Region: PRK08006 956149000247 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 956149000248 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 956149000249 Walker A motif; other site 956149000250 ATP binding site [chemical binding]; other site 956149000251 Walker B motif; other site 956149000252 DNA binding loops [nucleotide binding] 956149000253 alanine racemase; Reviewed; Region: alr; PRK00053 956149000254 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 956149000255 active site 956149000256 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 956149000257 substrate binding site [chemical binding]; other site 956149000258 catalytic residues [active] 956149000259 dimer interface [polypeptide binding]; other site 956149000260 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 956149000261 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 956149000262 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149000263 homodimer interface [polypeptide binding]; other site 956149000264 catalytic residue [active] 956149000265 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 956149000266 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 956149000267 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 956149000268 Uncharacterized conserved protein [Function unknown]; Region: COG0432 956149000269 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 956149000270 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 956149000271 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 956149000272 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 956149000273 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 956149000274 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 956149000275 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 956149000276 dimer interface [polypeptide binding]; other site 956149000277 ssDNA binding site [nucleotide binding]; other site 956149000278 tetramer (dimer of dimers) interface [polypeptide binding]; other site 956149000279 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 956149000280 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 956149000281 metal binding site [ion binding]; metal-binding site 956149000282 active site 956149000283 I-site; other site 956149000284 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 956149000285 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 956149000286 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 956149000287 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 956149000288 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 956149000289 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 956149000290 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 956149000291 DNA binding residues [nucleotide binding] 956149000292 dimer interface [polypeptide binding]; other site 956149000293 [2Fe-2S] cluster binding site [ion binding]; other site 956149000294 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 956149000295 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 956149000296 putative C-terminal domain interface [polypeptide binding]; other site 956149000297 putative GSH binding site (G-site) [chemical binding]; other site 956149000298 putative dimer interface [polypeptide binding]; other site 956149000299 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 956149000300 putative N-terminal domain interface [polypeptide binding]; other site 956149000301 putative dimer interface [polypeptide binding]; other site 956149000302 putative substrate binding pocket (H-site) [chemical binding]; other site 956149000303 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 956149000304 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 956149000305 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 956149000306 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 956149000307 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 956149000308 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 956149000309 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 956149000310 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 956149000311 Na binding site [ion binding]; other site 956149000312 Predicted membrane protein [Function unknown]; Region: COG3162 956149000313 acetyl-CoA synthetase; Provisional; Region: PRK00174 956149000314 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 956149000315 active site 956149000316 CoA binding site [chemical binding]; other site 956149000317 acyl-activating enzyme (AAE) consensus motif; other site 956149000318 AMP binding site [chemical binding]; other site 956149000319 acetate binding site [chemical binding]; other site 956149000320 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 956149000321 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 956149000322 Hok/gef family; Region: HOK_GEF; pfam01848 956149000323 Hok/gef family; Region: HOK_GEF; pfam01848 956149000324 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 956149000325 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 956149000326 ATP binding site [chemical binding]; other site 956149000327 Mg2+ binding site [ion binding]; other site 956149000328 G-X-G motif; other site 956149000329 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 956149000330 hypothetical protein; Provisional; Region: PRK10220 956149000331 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 956149000332 PhnA protein; Region: PhnA; pfam03831 956149000333 hypothetical protein; Provisional; Region: PRK09866 956149000334 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 956149000335 G1 box; other site 956149000336 GTP/Mg2+ binding site [chemical binding]; other site 956149000337 G2 box; other site 956149000338 Switch I region; other site 956149000339 G3 box; other site 956149000340 Switch II region; other site 956149000341 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 956149000342 G3 box; other site 956149000343 Switch II region; other site 956149000344 G4 box; other site 956149000345 G5 box; other site 956149000346 YjcZ-like protein; Region: YjcZ; pfam13990 956149000347 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 956149000348 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 956149000349 putative S-transferase; Provisional; Region: PRK11752 956149000350 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 956149000351 C-terminal domain interface [polypeptide binding]; other site 956149000352 GSH binding site (G-site) [chemical binding]; other site 956149000353 dimer interface [polypeptide binding]; other site 956149000354 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 956149000355 dimer interface [polypeptide binding]; other site 956149000356 N-terminal domain interface [polypeptide binding]; other site 956149000357 active site 956149000358 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 956149000359 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 956149000360 putative transcriptional regulator; Provisional; Region: PRK11640 956149000361 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 956149000362 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 956149000363 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 956149000364 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 956149000365 DsbD alpha interface [polypeptide binding]; other site 956149000366 catalytic residues [active] 956149000367 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 956149000368 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 956149000369 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 956149000370 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 956149000371 Aspartase; Region: Aspartase; cd01357 956149000372 active sites [active] 956149000373 tetramer interface [polypeptide binding]; other site 956149000374 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 956149000375 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 956149000376 oligomerisation interface [polypeptide binding]; other site 956149000377 mobile loop; other site 956149000378 roof hairpin; other site 956149000379 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 956149000380 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 956149000381 ring oligomerisation interface [polypeptide binding]; other site 956149000382 ATP/Mg binding site [chemical binding]; other site 956149000383 stacking interactions; other site 956149000384 hinge regions; other site 956149000385 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 956149000386 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 956149000387 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 956149000388 FeS/SAM binding site; other site 956149000389 elongation factor P; Validated; Region: PRK00529 956149000390 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 956149000391 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 956149000392 RNA binding site [nucleotide binding]; other site 956149000393 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 956149000394 RNA binding site [nucleotide binding]; other site 956149000395 entericidin A; Provisional; Region: PRK09810 956149000396 Entericidin EcnA/B family; Region: Entericidin; cl02322 956149000397 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 956149000398 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 956149000399 DNA binding residues [nucleotide binding] 956149000400 dimerization interface [polypeptide binding]; other site 956149000401 multidrug efflux system protein; Provisional; Region: PRK11431 956149000402 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 956149000403 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 956149000404 Iron-sulfur protein interface; other site 956149000405 proximal quinone binding site [chemical binding]; other site 956149000406 C-subunit interface; other site 956149000407 distal quinone binding site; other site 956149000408 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 956149000409 D-subunit interface [polypeptide binding]; other site 956149000410 Iron-sulfur protein interface; other site 956149000411 proximal quinone binding site [chemical binding]; other site 956149000412 distal quinone binding site [chemical binding]; other site 956149000413 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 956149000414 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 956149000415 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 956149000416 L-aspartate oxidase; Provisional; Region: PRK06175 956149000417 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 956149000418 poxB regulator PoxA; Provisional; Region: PRK09350 956149000419 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 956149000420 motif 1; other site 956149000421 dimer interface [polypeptide binding]; other site 956149000422 active site 956149000423 motif 2; other site 956149000424 motif 3; other site 956149000425 Protein of unknown function (DUF2645); Region: DUF2645; pfam10840 956149000426 putative mechanosensitive channel protein; Provisional; Region: PRK10929 956149000427 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 956149000428 Mechanosensitive ion channel; Region: MS_channel; pfam00924 956149000429 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 956149000430 GTPase RsgA; Reviewed; Region: PRK12288 956149000431 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 956149000432 RNA binding site [nucleotide binding]; other site 956149000433 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 956149000434 GTPase/Zn-binding domain interface [polypeptide binding]; other site 956149000435 GTP/Mg2+ binding site [chemical binding]; other site 956149000436 G4 box; other site 956149000437 G5 box; other site 956149000438 G1 box; other site 956149000439 Switch I region; other site 956149000440 G2 box; other site 956149000441 G3 box; other site 956149000442 Switch II region; other site 956149000443 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 956149000444 catalytic site [active] 956149000445 putative active site [active] 956149000446 putative substrate binding site [chemical binding]; other site 956149000447 dimer interface [polypeptide binding]; other site 956149000448 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 956149000449 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 956149000450 putative carbohydrate kinase; Provisional; Region: PRK10565 956149000451 Uncharacterized conserved protein [Function unknown]; Region: COG0062 956149000452 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 956149000453 putative substrate binding site [chemical binding]; other site 956149000454 putative ATP binding site [chemical binding]; other site 956149000455 ADP-binding protein; Provisional; Region: PRK10646 956149000456 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 956149000457 AMIN domain; Region: AMIN; pfam11741 956149000458 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 956149000459 active site 956149000460 metal binding site [ion binding]; metal-binding site 956149000461 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 956149000462 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 956149000463 ATP binding site [chemical binding]; other site 956149000464 Mg2+ binding site [ion binding]; other site 956149000465 G-X-G motif; other site 956149000466 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 956149000467 ATP binding site [chemical binding]; other site 956149000468 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 956149000469 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 956149000470 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 956149000471 bacterial Hfq-like; Region: Hfq; cd01716 956149000472 hexamer interface [polypeptide binding]; other site 956149000473 Sm1 motif; other site 956149000474 RNA binding site [nucleotide binding]; other site 956149000475 Sm2 motif; other site 956149000476 GTPase HflX; Provisional; Region: PRK11058 956149000477 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 956149000478 HflX GTPase family; Region: HflX; cd01878 956149000479 G1 box; other site 956149000480 GTP/Mg2+ binding site [chemical binding]; other site 956149000481 Switch I region; other site 956149000482 G2 box; other site 956149000483 G3 box; other site 956149000484 Switch II region; other site 956149000485 G4 box; other site 956149000486 G5 box; other site 956149000487 FtsH protease regulator HflK; Provisional; Region: PRK10930 956149000488 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 956149000489 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 956149000490 FtsH protease regulator HflC; Provisional; Region: PRK11029 956149000491 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 956149000492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 956149000493 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 956149000494 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 956149000495 GDP-binding site [chemical binding]; other site 956149000496 ACT binding site; other site 956149000497 IMP binding site; other site 956149000498 Predicted transcriptional regulator [Transcription]; Region: COG1959 956149000499 transcriptional repressor NsrR; Provisional; Region: PRK11014 956149000500 exoribonuclease R; Provisional; Region: PRK11642 956149000501 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 956149000502 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 956149000503 RNB domain; Region: RNB; pfam00773 956149000504 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 956149000505 RNA binding site [nucleotide binding]; other site 956149000506 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 956149000507 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 956149000508 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 956149000509 Predicted membrane protein [Function unknown]; Region: COG3766 956149000510 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 956149000511 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 956149000512 Protein of unknown function (DUF1190); Region: DUF1190; cl10031 956149000513 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 956149000514 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 956149000515 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 956149000516 active site 956149000517 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 956149000518 dimerization interface [polypeptide binding]; other site 956149000519 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 956149000520 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 956149000521 dimer interface [polypeptide binding]; other site 956149000522 putative CheW interface [polypeptide binding]; other site 956149000523 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 956149000524 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 956149000525 esterase; Provisional; Region: PRK10566 956149000526 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 956149000527 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 956149000528 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 956149000529 dimer interface [polypeptide binding]; other site 956149000530 ssDNA binding site [nucleotide binding]; other site 956149000531 tetramer (dimer of dimers) interface [polypeptide binding]; other site 956149000532 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 956149000533 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 956149000534 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 956149000535 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 956149000536 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 956149000537 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 956149000538 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 956149000539 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 956149000540 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 956149000541 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 956149000542 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 956149000543 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 956149000544 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 956149000545 Hemerythrin-like domain; Region: Hr-like; cd12108 956149000546 Fe binding site [ion binding]; other site 956149000547 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 956149000548 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 956149000549 dimer interface [polypeptide binding]; other site 956149000550 ligand binding site [chemical binding]; other site 956149000551 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 956149000552 dimerization interface [polypeptide binding]; other site 956149000553 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 956149000554 dimer interface [polypeptide binding]; other site 956149000555 putative CheW interface [polypeptide binding]; other site 956149000556 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 956149000557 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 956149000558 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 956149000559 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 956149000560 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 956149000561 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 956149000562 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 956149000563 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 956149000564 NADP binding site [chemical binding]; other site 956149000565 Predicted transcriptional regulators [Transcription]; Region: COG1733 956149000566 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 956149000567 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 956149000568 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 956149000569 active site 956149000570 metal binding site [ion binding]; metal-binding site 956149000571 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 956149000572 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 956149000573 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 956149000574 active site 956149000575 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 956149000576 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 956149000577 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 956149000578 Domain of unknown function DUF21; Region: DUF21; pfam01595 956149000579 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 956149000580 Transporter associated domain; Region: CorC_HlyC; smart01091 956149000581 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 956149000582 methionine sulfoxide reductase A; Provisional; Region: PRK00058 956149000583 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 956149000584 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 956149000585 Surface antigen; Region: Bac_surface_Ag; pfam01103 956149000586 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 956149000587 Family of unknown function (DUF490); Region: DUF490; pfam04357 956149000588 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 956149000589 putative active site pocket [active] 956149000590 dimerization interface [polypeptide binding]; other site 956149000591 putative catalytic residue [active] 956149000592 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 956149000593 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 956149000594 PapC N-terminal domain; Region: PapC_N; pfam13954 956149000595 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 956149000596 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 956149000597 PapC C-terminal domain; Region: PapC_C; pfam13953 956149000598 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 956149000599 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 956149000600 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 956149000601 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 956149000602 Fimbrial protein; Region: Fimbrial; pfam00419 956149000603 Fimbrial protein; Region: Fimbrial; cl01416 956149000604 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 956149000605 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 956149000606 O-Antigen ligase; Region: Wzy_C; pfam04932 956149000607 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 956149000608 dimerization interface [polypeptide binding]; other site 956149000609 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 956149000610 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 956149000611 dimer interface [polypeptide binding]; other site 956149000612 putative CheW interface [polypeptide binding]; other site 956149000613 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 956149000614 dimer interface [polypeptide binding]; other site 956149000615 substrate binding site [chemical binding]; other site 956149000616 metal binding sites [ion binding]; metal-binding site 956149000617 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 956149000618 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 956149000619 putative ligand binding site [chemical binding]; other site 956149000620 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 956149000621 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 956149000622 Walker A/P-loop; other site 956149000623 ATP binding site [chemical binding]; other site 956149000624 Q-loop/lid; other site 956149000625 ABC transporter signature motif; other site 956149000626 Walker B; other site 956149000627 D-loop; other site 956149000628 H-loop/switch region; other site 956149000629 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 956149000630 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 956149000631 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 956149000632 TM-ABC transporter signature motif; other site 956149000633 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 956149000634 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 956149000635 TM-ABC transporter signature motif; other site 956149000636 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 956149000637 dimer interface [polypeptide binding]; other site 956149000638 ligand binding site [chemical binding]; other site 956149000639 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 956149000640 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 956149000641 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 956149000642 dimer interface [polypeptide binding]; other site 956149000643 putative CheW interface [polypeptide binding]; other site 956149000644 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 956149000645 AMP binding site [chemical binding]; other site 956149000646 metal binding site [ion binding]; metal-binding site 956149000647 active site 956149000648 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 956149000649 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 956149000650 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 956149000651 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 956149000652 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 956149000653 active site 956149000654 catalytic residues [active] 956149000655 hypothetical protein; Provisional; Region: PRK05255 956149000656 peptidase PmbA; Provisional; Region: PRK11040 956149000657 cytochrome b562; Provisional; Region: PRK15058 956149000658 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 956149000659 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; cl11916 956149000660 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 956149000661 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 956149000662 Domain of unknown function (DUF4310); Region: DUF4310; pfam14187 956149000663 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 956149000664 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 956149000665 active site 956149000666 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 956149000667 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 956149000668 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 956149000669 HTH domain; Region: HTH_11; pfam08279 956149000670 Mga helix-turn-helix domain; Region: Mga; pfam05043 956149000671 PRD domain; Region: PRD; pfam00874 956149000672 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 956149000673 active site 956149000674 P-loop; other site 956149000675 phosphorylation site [posttranslational modification] 956149000676 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 956149000677 active site 956149000678 phosphorylation site [posttranslational modification] 956149000679 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 956149000680 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 956149000681 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; PRK11121 956149000682 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 956149000683 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 956149000684 ATP cone domain; Region: ATP-cone; pfam03477 956149000685 Class III ribonucleotide reductase; Region: RNR_III; cd01675 956149000686 effector binding site; other site 956149000687 active site 956149000688 Zn binding site [ion binding]; other site 956149000689 glycine loop; other site 956149000690 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 956149000691 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149000692 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 956149000693 putative effector binding pocket; other site 956149000694 dimerization interface [polypeptide binding]; other site 956149000695 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 956149000696 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 956149000697 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 956149000698 Ca binding site [ion binding]; other site 956149000699 active site 956149000700 catalytic site [active] 956149000701 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 956149000702 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 956149000703 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 956149000704 active site turn [active] 956149000705 phosphorylation site [posttranslational modification] 956149000706 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 956149000707 trehalose repressor; Provisional; Region: treR; PRK09492 956149000708 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 956149000709 DNA binding site [nucleotide binding] 956149000710 domain linker motif; other site 956149000711 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 956149000712 dimerization interface [polypeptide binding]; other site 956149000713 ligand binding site [chemical binding]; other site 956149000714 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 956149000715 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 956149000716 glutaredoxin 2; Provisional; Region: PRK10387 956149000717 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 956149000718 C-terminal domain interface [polypeptide binding]; other site 956149000719 GSH binding site (G-site) [chemical binding]; other site 956149000720 catalytic residues [active] 956149000721 putative dimer interface [polypeptide binding]; other site 956149000722 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 956149000723 N-terminal domain interface [polypeptide binding]; other site 956149000724 Uncharacterized conserved protein [Function unknown]; Region: COG1359 956149000725 lipoprotein LpqB; Provisional; Region: PRK13616 956149000726 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 956149000727 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 956149000728 active site 956149000729 catalytic tetrad [active] 956149000730 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 956149000731 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 956149000732 dimer interface [polypeptide binding]; other site 956149000733 active site 956149000734 metal binding site [ion binding]; metal-binding site 956149000735 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 956149000736 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 956149000737 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 956149000738 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 956149000739 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 956149000740 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 956149000741 cystathionine beta-lyase; Provisional; Region: PRK08114 956149000742 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 956149000743 homodimer interface [polypeptide binding]; other site 956149000744 substrate-cofactor binding pocket; other site 956149000745 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149000746 catalytic residue [active] 956149000747 biopolymer transport protein ExbB; Provisional; Region: PRK10414 956149000748 biopolymer transport protein ExbD; Provisional; Region: PRK11267 956149000749 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 956149000750 oxidoreductase; Provisional; Region: PRK07985 956149000751 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 956149000752 NAD binding site [chemical binding]; other site 956149000753 metal binding site [ion binding]; metal-binding site 956149000754 active site 956149000755 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 956149000756 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 956149000757 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 956149000758 hypothetical protein; Provisional; Region: PRK05208 956149000759 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 956149000760 Mechanosensitive ion channel; Region: MS_channel; pfam00924 956149000761 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 956149000762 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 956149000763 methionine cluster; other site 956149000764 active site 956149000765 phosphorylation site [posttranslational modification] 956149000766 metal binding site [ion binding]; metal-binding site 956149000767 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 956149000768 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 956149000769 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 956149000770 active site 956149000771 P-loop; other site 956149000772 phosphorylation site [posttranslational modification] 956149000773 Transcriptional regulators [Transcription]; Region: PurR; COG1609 956149000774 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 956149000775 DNA binding site [nucleotide binding] 956149000776 domain linker motif; other site 956149000777 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 956149000778 ligand binding site [chemical binding]; other site 956149000779 Predicted membrane protein (DUF2238); Region: DUF2238; cl01464 956149000780 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 956149000781 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 956149000782 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 956149000783 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 956149000784 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 956149000785 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 956149000786 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 956149000787 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 956149000788 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 956149000789 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 956149000790 active site 956149000791 catalytic triad [active] 956149000792 oxyanion hole [active] 956149000793 potential frameshift: common BLAST hit: gi|197286499|ref|YP_002152371.1| lipoprotein 956149000794 Uncharacterized protein conserved in bacteria (DUF2138); Region: DUF2138; cl01916 956149000795 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 956149000796 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 956149000797 Protein of unknown function (DUF554); Region: DUF554; pfam04474 956149000798 ornithine decarboxylase; Provisional; Region: PRK13578 956149000799 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 956149000800 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 956149000801 homodimer interface [polypeptide binding]; other site 956149000802 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149000803 catalytic residue [active] 956149000804 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 956149000805 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 956149000806 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 956149000807 active site 956149000808 phosphorylation site [posttranslational modification] 956149000809 intermolecular recognition site; other site 956149000810 dimerization interface [polypeptide binding]; other site 956149000811 Transcriptional regulator; Region: CitT; pfam12431 956149000812 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 956149000813 PAS domain; Region: PAS; smart00091 956149000814 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 956149000815 ATP binding site [chemical binding]; other site 956149000816 Mg2+ binding site [ion binding]; other site 956149000817 G-X-G motif; other site 956149000818 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 956149000819 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 956149000820 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 956149000821 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 956149000822 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 956149000823 putative active site [active] 956149000824 (T/H)XGH motif; other site 956149000825 citrate lyase subunit gamma; Provisional; Region: PRK13253 956149000826 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 956149000827 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 956149000828 Coenzyme A transferase; Region: CoA_trans; cl17247 956149000829 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 956149000830 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 956149000831 murein transglycosylase C; Provisional; Region: mltC; PRK11671 956149000832 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 956149000833 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 956149000834 N-acetyl-D-glucosamine binding site [chemical binding]; other site 956149000835 catalytic residue [active] 956149000836 oxidative damage protection protein; Provisional; Region: PRK05408 956149000837 adenine DNA glycosylase; Provisional; Region: PRK10880 956149000838 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 956149000839 minor groove reading motif; other site 956149000840 helix-hairpin-helix signature motif; other site 956149000841 substrate binding pocket [chemical binding]; other site 956149000842 active site 956149000843 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 956149000844 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 956149000845 DNA binding and oxoG recognition site [nucleotide binding] 956149000846 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 956149000847 hypothetical protein; Provisional; Region: PRK11702 956149000848 hypothetical protein; Provisional; Region: PRK10626 956149000849 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 956149000850 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 956149000851 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 956149000852 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 956149000853 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 956149000854 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 956149000855 Uncharacterized small protein [Function unknown]; Region: COG2879 956149000856 carbon starvation protein A; Provisional; Region: PRK15015 956149000857 Carbon starvation protein CstA; Region: CstA; pfam02554 956149000858 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 956149000859 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 956149000860 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 956149000861 dimerization interface [polypeptide binding]; other site 956149000862 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 956149000863 dimer interface [polypeptide binding]; other site 956149000864 putative CheW interface [polypeptide binding]; other site 956149000865 beta-carotene hydroxylase; Region: PLN02601 956149000866 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 956149000867 active site lid residues [active] 956149000868 substrate binding pocket [chemical binding]; other site 956149000869 catalytic residues [active] 956149000870 substrate-Mg2+ binding site; other site 956149000871 aspartate-rich region 1; other site 956149000872 aspartate-rich region 2; other site 956149000873 phytoene desaturase; Region: crtI_fam; TIGR02734 956149000874 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 956149000875 Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834 956149000876 lycopene cyclase; Region: lycopene_cycl; TIGR01789 956149000877 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 956149000878 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 956149000879 active site 956149000880 TDP-binding site; other site 956149000881 acceptor substrate-binding pocket; other site 956149000882 homodimer interface [polypeptide binding]; other site 956149000883 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 956149000884 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 956149000885 homotetramer interface [polypeptide binding]; other site 956149000886 FMN binding site [chemical binding]; other site 956149000887 homodimer contacts [polypeptide binding]; other site 956149000888 putative active site [active] 956149000889 putative substrate binding site [chemical binding]; other site 956149000890 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 956149000891 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 956149000892 substrate binding pocket [chemical binding]; other site 956149000893 chain length determination region; other site 956149000894 substrate-Mg2+ binding site; other site 956149000895 catalytic residues [active] 956149000896 aspartate-rich region 1; other site 956149000897 active site lid residues [active] 956149000898 aspartate-rich region 2; other site 956149000899 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 956149000900 integrase; Provisional; Region: int; PHA02601 956149000901 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 956149000902 active site 956149000903 DNA binding site [nucleotide binding] 956149000904 Int/Topo IB signature motif; other site 956149000905 hypothetical protein; Provisional; Region: PRK10040 956149000906 Predicted transcriptional regulator [Transcription]; Region: COG2932 956149000907 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 956149000908 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 956149000909 Catalytic site [active] 956149000910 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 956149000911 Protein of unknown function (DUF2724); Region: DUF2724; pfam10893 956149000912 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 956149000913 DksA-like zinc finger domain containing protein; Region: PHA00080 956149000914 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 956149000915 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 956149000916 active site 956149000917 catalytic site [active] 956149000918 substrate binding site [chemical binding]; other site 956149000919 Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961 956149000920 DNA adenine methylase (dam); Region: dam; TIGR00571 956149000921 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 956149000922 DinI-like family; Region: DinI; pfam06183 956149000923 portal vertex protein; Provisional; Region: Q; PHA02536 956149000924 Phage portal protein; Region: Phage_portal; pfam04860 956149000925 terminase ATPase subunit; Provisional; Region: P; PHA02535 956149000926 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 956149000927 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 956149000928 capsid protein; Provisional; Region: N; PHA02538 956149000929 terminase endonuclease subunit; Provisional; Region: M; PHA02537 956149000930 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 956149000931 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 956149000932 P2-like prophage tail protein X [General function prediction only]; Region: COG5004 956149000933 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 956149000934 catalytic residues [active] 956149000935 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 956149000936 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 956149000937 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 956149000938 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 956149000939 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 956149000940 baseplate wedge subunit; Provisional; Region: W; PHA02516 956149000941 baseplate assembly protein; Provisional; Region: J; PHA02568 956149000942 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 956149000943 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 956149000944 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 956149000945 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 956149000946 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 956149000947 catalytic residues [active] 956149000948 catalytic nucleophile [active] 956149000949 Presynaptic Site I dimer interface [polypeptide binding]; other site 956149000950 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 956149000951 Synaptic Flat tetramer interface [polypeptide binding]; other site 956149000952 Synaptic Site I dimer interface [polypeptide binding]; other site 956149000953 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 956149000954 DNA-binding interface [nucleotide binding]; DNA binding site 956149000955 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 956149000956 DNA methylase; Region: N6_N4_Mtase; pfam01555 956149000957 major tail sheath protein; Provisional; Region: FI; PHA02560 956149000958 major tail tube protein; Provisional; Region: FII; PHA02600 956149000959 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 956149000960 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 956149000961 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 956149000962 Phage protein U [General function prediction only]; Region: COG3499 956149000963 tail protein; Provisional; Region: D; PHA02561 956149000964 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 956149000965 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 956149000966 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 956149000967 active site 956149000968 SUMO-1 interface [polypeptide binding]; other site 956149000969 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 956149000970 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 956149000971 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 956149000972 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 956149000973 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 956149000974 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 956149000975 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 956149000976 DNA binding residues [nucleotide binding] 956149000977 DNA primase; Validated; Region: dnaG; PRK05667 956149000978 CHC2 zinc finger; Region: zf-CHC2; pfam01807 956149000979 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 956149000980 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 956149000981 active site 956149000982 metal binding site [ion binding]; metal-binding site 956149000983 interdomain interaction site; other site 956149000984 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 956149000985 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 956149000986 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 956149000987 UGMP family protein; Validated; Region: PRK09604 956149000988 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 956149000989 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 956149000990 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 956149000991 homooctamer interface [polypeptide binding]; other site 956149000992 active site 956149000993 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 956149000994 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 956149000995 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 956149000996 active site 956149000997 NTP binding site [chemical binding]; other site 956149000998 metal binding triad [ion binding]; metal-binding site 956149000999 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 956149001000 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 956149001001 Zn2+ binding site [ion binding]; other site 956149001002 Mg2+ binding site [ion binding]; other site 956149001003 SH3 domain-containing protein; Provisional; Region: PRK10884 956149001004 Bacterial SH3 domain homologues; Region: SH3b; smart00287 956149001005 Uncharacterized conserved protein [Function unknown]; Region: COG3025 956149001006 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 956149001007 putative active site [active] 956149001008 putative metal binding residues [ion binding]; other site 956149001009 signature motif; other site 956149001010 putative triphosphate binding site [ion binding]; other site 956149001011 CHAD domain; Region: CHAD; pfam05235 956149001012 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 956149001013 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 956149001014 metal binding triad; other site 956149001015 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 956149001016 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 956149001017 metal binding triad; other site 956149001018 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 956149001019 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 956149001020 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 956149001021 putative ribose interaction site [chemical binding]; other site 956149001022 putative ADP binding site [chemical binding]; other site 956149001023 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 956149001024 active site 956149001025 nucleotide binding site [chemical binding]; other site 956149001026 HIGH motif; other site 956149001027 KMSKS motif; other site 956149001028 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 956149001029 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 956149001030 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 956149001031 zinc transporter ZupT; Provisional; Region: PRK04201 956149001032 ZIP Zinc transporter; Region: Zip; pfam02535 956149001033 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 956149001034 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 956149001035 putative active site [active] 956149001036 metal binding site [ion binding]; metal-binding site 956149001037 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 956149001038 hypothetical protein; Provisional; Region: PRK11653 956149001039 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 956149001040 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 956149001041 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 956149001042 dimer interface [polypeptide binding]; other site 956149001043 ADP-ribose binding site [chemical binding]; other site 956149001044 active site 956149001045 nudix motif; other site 956149001046 metal binding site [ion binding]; metal-binding site 956149001047 putative dehydrogenase; Provisional; Region: PRK11039 956149001048 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 956149001049 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 956149001050 active site 956149001051 metal binding site [ion binding]; metal-binding site 956149001052 hexamer interface [polypeptide binding]; other site 956149001053 esterase YqiA; Provisional; Region: PRK11071 956149001054 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 956149001055 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 956149001056 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 956149001057 ATP binding site [chemical binding]; other site 956149001058 Mg2+ binding site [ion binding]; other site 956149001059 G-X-G motif; other site 956149001060 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 956149001061 anchoring element; other site 956149001062 dimer interface [polypeptide binding]; other site 956149001063 ATP binding site [chemical binding]; other site 956149001064 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 956149001065 active site 956149001066 metal binding site [ion binding]; metal-binding site 956149001067 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 956149001068 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 956149001069 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 956149001070 heme binding site [chemical binding]; other site 956149001071 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 956149001072 Uncharacterized conserved protein [Function unknown]; Region: COG1359 956149001073 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 956149001074 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 956149001075 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 956149001076 CAP-like domain; other site 956149001077 active site 956149001078 primary dimer interface [polypeptide binding]; other site 956149001079 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 956149001080 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 956149001081 putative acyl-acceptor binding pocket; other site 956149001082 FtsI repressor; Provisional; Region: PRK10883 956149001083 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 956149001084 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 956149001085 HemN family oxidoreductase; Provisional; Region: PRK05660 956149001086 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 956149001087 FeS/SAM binding site; other site 956149001088 HemN C-terminal domain; Region: HemN_C; pfam06969 956149001089 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 956149001090 active site 956149001091 dimerization interface [polypeptide binding]; other site 956149001092 hypothetical protein; Validated; Region: PRK05090 956149001093 YGGT family; Region: YGGT; pfam02325 956149001094 Predicted integral membrane protein [Function unknown]; Region: COG0762 956149001095 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 956149001096 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 956149001097 catalytic residue [active] 956149001098 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 956149001099 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 956149001100 Walker A motif; other site 956149001101 ATP binding site [chemical binding]; other site 956149001102 Walker B motif; other site 956149001103 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 956149001104 Transcriptional regulator [Transcription]; Region: IclR; COG1414 956149001105 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 956149001106 hypothetical protein; Validated; Region: PRK00228 956149001107 glutathione synthetase; Provisional; Region: PRK05246 956149001108 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 956149001109 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 956149001110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 956149001111 RNA methyltransferase, RsmE family; Region: TIGR00046 956149001112 DNA-specific endonuclease I; Provisional; Region: PRK15137 956149001113 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 956149001114 hypothetical protein; Provisional; Region: PRK04860 956149001115 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 956149001116 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 956149001117 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149001118 putative substrate translocation pore; other site 956149001119 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149001120 S-adenosylmethionine synthetase; Validated; Region: PRK05250 956149001121 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 956149001122 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 956149001123 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 956149001124 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 956149001125 Virulence promoting factor; Region: YqgB; pfam11036 956149001126 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 956149001127 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 956149001128 dimer interface [polypeptide binding]; other site 956149001129 active site 956149001130 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 956149001131 catalytic residues [active] 956149001132 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 956149001133 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 956149001134 agmatinase; Region: agmatinase; TIGR01230 956149001135 oligomer interface [polypeptide binding]; other site 956149001136 putative active site [active] 956149001137 Mn binding site [ion binding]; other site 956149001138 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 956149001139 transketolase; Reviewed; Region: PRK12753 956149001140 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 956149001141 TPP-binding site [chemical binding]; other site 956149001142 dimer interface [polypeptide binding]; other site 956149001143 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 956149001144 PYR/PP interface [polypeptide binding]; other site 956149001145 dimer interface [polypeptide binding]; other site 956149001146 TPP binding site [chemical binding]; other site 956149001147 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 956149001148 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 956149001149 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 956149001150 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 956149001151 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 956149001152 Phosphoglycerate kinase; Region: PGK; pfam00162 956149001153 substrate binding site [chemical binding]; other site 956149001154 hinge regions; other site 956149001155 ADP binding site [chemical binding]; other site 956149001156 catalytic site [active] 956149001157 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 956149001158 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 956149001159 active site 956149001160 intersubunit interface [polypeptide binding]; other site 956149001161 zinc binding site [ion binding]; other site 956149001162 Na+ binding site [ion binding]; other site 956149001163 mechanosensitive channel MscS; Provisional; Region: PRK10334 956149001164 Mechanosensitive ion channel; Region: MS_channel; pfam00924 956149001165 arginine exporter protein; Provisional; Region: PRK09304 956149001166 Uncharacterized conserved protein [Function unknown]; Region: COG2968 956149001167 oxidative stress defense protein; Provisional; Region: PRK11087 956149001168 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 956149001169 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149001170 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 956149001171 putative dimerization interface [polypeptide binding]; other site 956149001172 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 956149001173 tetramer (dimer of dimers) interface [polypeptide binding]; other site 956149001174 active site 956149001175 dimer interface [polypeptide binding]; other site 956149001176 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 956149001177 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 956149001178 ligand binding site [chemical binding]; other site 956149001179 NAD binding site [chemical binding]; other site 956149001180 tetramer interface [polypeptide binding]; other site 956149001181 catalytic site [active] 956149001182 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 956149001183 L-serine binding site [chemical binding]; other site 956149001184 ACT domain interface; other site 956149001185 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 956149001186 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 956149001187 Z-ring-associated protein; Provisional; Region: PRK10972 956149001188 hypothetical protein; Reviewed; Region: PRK01736 956149001189 proline aminopeptidase P II; Provisional; Region: PRK10879 956149001190 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 956149001191 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 956149001192 active site 956149001193 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 956149001194 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 956149001195 oxidoreductase; Provisional; Region: PRK08013 956149001196 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 956149001197 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 956149001198 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 956149001199 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 956149001200 lipoyl attachment site [posttranslational modification]; other site 956149001201 glycine dehydrogenase; Provisional; Region: PRK05367 956149001202 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 956149001203 tetramer interface [polypeptide binding]; other site 956149001204 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149001205 catalytic residue [active] 956149001206 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 956149001207 tetramer interface [polypeptide binding]; other site 956149001208 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149001209 catalytic residue [active] 956149001210 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 956149001211 classical (c) SDRs; Region: SDR_c; cd05233 956149001212 NAD(P) binding site [chemical binding]; other site 956149001213 active site 956149001214 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 956149001215 beta-galactosidase; Region: BGL; TIGR03356 956149001216 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 956149001217 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 956149001218 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 956149001219 putative active site [active] 956149001220 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 956149001221 hemolysin; Provisional; Region: PRK15087 956149001222 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 956149001223 putative global regulator; Reviewed; Region: PRK09559 956149001224 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 956149001225 hypothetical protein; Provisional; Region: PRK10878 956149001226 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 956149001227 flavodoxin FldB; Provisional; Region: PRK12359 956149001228 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 956149001229 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 956149001230 active site 956149001231 Int/Topo IB signature motif; other site 956149001232 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 956149001233 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 956149001234 dimerization domain [polypeptide binding]; other site 956149001235 dimer interface [polypeptide binding]; other site 956149001236 catalytic residues [active] 956149001237 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 956149001238 DHH family; Region: DHH; pfam01368 956149001239 DHHA1 domain; Region: DHHA1; pfam02272 956149001240 This domain is found in peptide chain release factors; Region: PCRF; smart00937 956149001241 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 956149001242 RF-1 domain; Region: RF-1; pfam00472 956149001243 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 956149001244 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 956149001245 dimer interface [polypeptide binding]; other site 956149001246 putative anticodon binding site; other site 956149001247 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 956149001248 motif 1; other site 956149001249 active site 956149001250 motif 2; other site 956149001251 motif 3; other site 956149001252 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 956149001253 Peptidase family M23; Region: Peptidase_M23; pfam01551 956149001254 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 956149001255 synthetase active site [active] 956149001256 NTP binding site [chemical binding]; other site 956149001257 metal binding site [ion binding]; metal-binding site 956149001258 multiple promoter invertase; Provisional; Region: mpi; PRK13413 956149001259 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 956149001260 catalytic residues [active] 956149001261 catalytic nucleophile [active] 956149001262 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 956149001263 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 956149001264 non-specific DNA binding site [nucleotide binding]; other site 956149001265 salt bridge; other site 956149001266 sequence-specific DNA binding site [nucleotide binding]; other site 956149001267 Recombination endonuclease VII; Region: Endonuclease_7; pfam02945 956149001268 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 956149001269 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 956149001270 active site 956149001271 DNA binding site [nucleotide binding] 956149001272 Int/Topo IB signature motif; other site 956149001273 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 956149001274 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 956149001275 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 956149001276 ligand binding site [chemical binding]; other site 956149001277 flexible hinge region; other site 956149001278 Transcriptional regulator; Region: Rrf2; cl17282 956149001279 putative acyltransferase; Provisional; Region: PRK05790 956149001280 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 956149001281 dimer interface [polypeptide binding]; other site 956149001282 active site 956149001283 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 956149001284 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 956149001285 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 956149001286 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 956149001287 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 956149001288 NADP binding site [chemical binding]; other site 956149001289 homodimer interface [polypeptide binding]; other site 956149001290 active site 956149001291 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 956149001292 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 956149001293 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 956149001294 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 956149001295 Walker A/P-loop; other site 956149001296 ATP binding site [chemical binding]; other site 956149001297 Q-loop/lid; other site 956149001298 ABC transporter signature motif; other site 956149001299 Walker B; other site 956149001300 D-loop; other site 956149001301 H-loop/switch region; other site 956149001302 TOBE domain; Region: TOBE; pfam03459 956149001303 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 956149001304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149001305 dimer interface [polypeptide binding]; other site 956149001306 conserved gate region; other site 956149001307 putative PBP binding loops; other site 956149001308 ABC-ATPase subunit interface; other site 956149001309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149001310 dimer interface [polypeptide binding]; other site 956149001311 conserved gate region; other site 956149001312 putative PBP binding loops; other site 956149001313 ABC-ATPase subunit interface; other site 956149001314 LPS O-antigen length regulator; Provisional; Region: PRK10381 956149001315 Chain length determinant protein; Region: Wzz; pfam02706 956149001316 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 956149001317 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 956149001318 aspartate racemase; Region: asp_race; TIGR00035 956149001319 putative racemase; Provisional; Region: PRK10200 956149001320 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 956149001321 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149001322 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 956149001323 dimerization interface [polypeptide binding]; other site 956149001324 diaminopimelate decarboxylase; Provisional; Region: PRK11165 956149001325 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 956149001326 active site 956149001327 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 956149001328 substrate binding site [chemical binding]; other site 956149001329 catalytic residues [active] 956149001330 dimer interface [polypeptide binding]; other site 956149001331 Transcriptional regulators [Transcription]; Region: PurR; COG1609 956149001332 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 956149001333 DNA binding site [nucleotide binding] 956149001334 domain linker motif; other site 956149001335 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 956149001336 dimerization interface (closed form) [polypeptide binding]; other site 956149001337 ligand binding site [chemical binding]; other site 956149001338 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 956149001339 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 956149001340 beta-galactosidase; Region: BGL; TIGR03356 956149001341 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 956149001342 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 956149001343 active site 956149001344 P-loop; other site 956149001345 phosphorylation site [posttranslational modification] 956149001346 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 956149001347 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 956149001348 DNA-binding site [nucleotide binding]; DNA binding site 956149001349 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 956149001350 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 956149001351 Coenzyme A binding pocket [chemical binding]; other site 956149001352 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 956149001353 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 956149001354 DNA binding site [nucleotide binding] 956149001355 domain linker motif; other site 956149001356 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 956149001357 dimerization interface (closed form) [polypeptide binding]; other site 956149001358 ligand binding site [chemical binding]; other site 956149001359 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 956149001360 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 956149001361 putative acyl-acceptor binding pocket; other site 956149001362 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 956149001363 acyl-activating enzyme (AAE) consensus motif; other site 956149001364 putative AMP binding site [chemical binding]; other site 956149001365 lysophospholipid transporter LplT; Provisional; Region: PRK11195 956149001366 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149001367 putative substrate translocation pore; other site 956149001368 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 956149001369 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 956149001370 active site 956149001371 catalytic tetrad [active] 956149001372 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 956149001373 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 956149001374 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 956149001375 putative DNA-binding cleft [nucleotide binding]; other site 956149001376 putative DNA clevage site; other site 956149001377 molecular lever; other site 956149001378 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 956149001379 putative active site [active] 956149001380 Ap4A binding site [chemical binding]; other site 956149001381 nudix motif; other site 956149001382 putative metal binding site [ion binding]; other site 956149001383 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 956149001384 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 956149001385 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 956149001386 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 956149001387 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 956149001388 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 956149001389 thymidylate synthase; Reviewed; Region: thyA; PRK01827 956149001390 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 956149001391 dimerization interface [polypeptide binding]; other site 956149001392 active site 956149001393 hypothetical protein; Provisional; Region: PRK10506 956149001394 hypothetical protein; Provisional; Region: PRK10557 956149001395 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 956149001396 Protein of unknown function (DUF2509); Region: DUF2509; cl11672 956149001397 hypothetical protein; Provisional; Region: PRK10332 956149001398 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 956149001399 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 956149001400 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 956149001401 protease3; Provisional; Region: PRK15101 956149001402 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 956149001403 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 956149001404 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 956149001405 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 956149001406 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 956149001407 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 956149001408 AAA domain; Region: AAA_30; pfam13604 956149001409 Family description; Region: UvrD_C_2; pfam13538 956149001410 N-acetylglutamate synthase; Validated; Region: PRK05279 956149001411 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 956149001412 putative feedback inhibition sensing region; other site 956149001413 putative nucleotide binding site [chemical binding]; other site 956149001414 putative substrate binding site [chemical binding]; other site 956149001415 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 956149001416 Coenzyme A binding pocket [chemical binding]; other site 956149001417 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 956149001418 AMIN domain; Region: AMIN; pfam11741 956149001419 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 956149001420 active site 956149001421 metal binding site [ion binding]; metal-binding site 956149001422 murein transglycosylase A; Provisional; Region: mltA; PRK11162 956149001423 MltA specific insert domain; Region: MltA; smart00925 956149001424 3D domain; Region: 3D; pfam06725 956149001425 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 956149001426 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 956149001427 putative ATP binding site [chemical binding]; other site 956149001428 putative substrate interface [chemical binding]; other site 956149001429 Fe-S metabolism associated domain; Region: SufE; cl00951 956149001430 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 956149001431 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 956149001432 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 956149001433 catalytic residue [active] 956149001434 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 956149001435 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 956149001436 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149001437 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 956149001438 dimerization interface [polypeptide binding]; other site 956149001439 substrate binding pocket [chemical binding]; other site 956149001440 hypothetical protein; Provisional; Region: PRK10873 956149001441 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 956149001442 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 956149001443 flap endonuclease-like protein; Provisional; Region: PRK09482 956149001444 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 956149001445 active site 956149001446 metal binding site 1 [ion binding]; metal-binding site 956149001447 putative 5' ssDNA interaction site; other site 956149001448 metal binding site 3; metal-binding site 956149001449 metal binding site 2 [ion binding]; metal-binding site 956149001450 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 956149001451 putative DNA binding site [nucleotide binding]; other site 956149001452 putative metal binding site [ion binding]; other site 956149001453 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 956149001454 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 956149001455 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 956149001456 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 956149001457 serine transporter; Region: stp; TIGR00814 956149001458 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 956149001459 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 956149001460 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 956149001461 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 956149001462 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 956149001463 SecY interacting protein Syd; Provisional; Region: PRK04968 956149001464 tRNA pseudouridine synthase C; Region: DUF446; cl01187 956149001465 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 956149001466 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 956149001467 probable active site [active] 956149001468 flavodoxin; Provisional; Region: PRK08105 956149001469 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 956149001470 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 956149001471 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 956149001472 dimerization interface [polypeptide binding]; other site 956149001473 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 956149001474 dimer interface [polypeptide binding]; other site 956149001475 phosphorylation site [posttranslational modification] 956149001476 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 956149001477 ATP binding site [chemical binding]; other site 956149001478 Mg2+ binding site [ion binding]; other site 956149001479 G-X-G motif; other site 956149001480 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 956149001481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 956149001482 active site 956149001483 phosphorylation site [posttranslational modification] 956149001484 intermolecular recognition site; other site 956149001485 dimerization interface [polypeptide binding]; other site 956149001486 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 956149001487 putative binding surface; other site 956149001488 active site 956149001489 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 956149001490 TRAM domain; Region: TRAM; pfam01938 956149001491 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 956149001492 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 956149001493 S-adenosylmethionine binding site [chemical binding]; other site 956149001494 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 956149001495 HD domain; Region: HD_4; pfam13328 956149001496 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 956149001497 synthetase active site [active] 956149001498 NTP binding site [chemical binding]; other site 956149001499 metal binding site [ion binding]; metal-binding site 956149001500 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 956149001501 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 956149001502 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 956149001503 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 956149001504 homodimer interface [polypeptide binding]; other site 956149001505 metal binding site [ion binding]; metal-binding site 956149001506 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 956149001507 homodimer interface [polypeptide binding]; other site 956149001508 active site 956149001509 putative chemical substrate binding site [chemical binding]; other site 956149001510 metal binding site [ion binding]; metal-binding site 956149001511 CTP synthetase; Validated; Region: pyrG; PRK05380 956149001512 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 956149001513 Catalytic site [active] 956149001514 active site 956149001515 UTP binding site [chemical binding]; other site 956149001516 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 956149001517 active site 956149001518 putative oxyanion hole; other site 956149001519 catalytic triad [active] 956149001520 enolase; Provisional; Region: eno; PRK00077 956149001521 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 956149001522 dimer interface [polypeptide binding]; other site 956149001523 metal binding site [ion binding]; metal-binding site 956149001524 substrate binding pocket [chemical binding]; other site 956149001525 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 956149001526 NAD(P) binding site [chemical binding]; other site 956149001527 active site 956149001528 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 956149001529 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 956149001530 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 956149001531 putative active site [active] 956149001532 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 956149001533 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 956149001534 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 956149001535 active site turn [active] 956149001536 phosphorylation site [posttranslational modification] 956149001537 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 956149001538 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 956149001539 putative active site cavity [active] 956149001540 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 956149001541 Repair protein; Region: Repair_PSII; pfam04536 956149001542 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 956149001543 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 956149001544 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 956149001545 active site 956149001546 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 956149001547 Flavodoxin; Region: Flavodoxin_1; pfam00258 956149001548 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 956149001549 FAD binding pocket [chemical binding]; other site 956149001550 FAD binding motif [chemical binding]; other site 956149001551 catalytic residues [active] 956149001552 NAD binding pocket [chemical binding]; other site 956149001553 phosphate binding motif [ion binding]; other site 956149001554 beta-alpha-beta structure motif; other site 956149001555 sulfite reductase subunit beta; Provisional; Region: PRK13504 956149001556 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 956149001557 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 956149001558 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 956149001559 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 956149001560 Active Sites [active] 956149001561 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 956149001562 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 956149001563 metal binding site [ion binding]; metal-binding site 956149001564 siroheme synthase; Provisional; Region: cysG; PRK10637 956149001565 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 956149001566 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 956149001567 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 956149001568 active site 956149001569 SAM binding site [chemical binding]; other site 956149001570 homodimer interface [polypeptide binding]; other site 956149001571 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 956149001572 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 956149001573 Active Sites [active] 956149001574 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 956149001575 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 956149001576 CysD dimerization site [polypeptide binding]; other site 956149001577 G1 box; other site 956149001578 putative GEF interaction site [polypeptide binding]; other site 956149001579 GTP/Mg2+ binding site [chemical binding]; other site 956149001580 Switch I region; other site 956149001581 G2 box; other site 956149001582 G3 box; other site 956149001583 Switch II region; other site 956149001584 G4 box; other site 956149001585 G5 box; other site 956149001586 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 956149001587 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 956149001588 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 956149001589 ligand-binding site [chemical binding]; other site 956149001590 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 956149001591 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 956149001592 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 956149001593 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 956149001594 substrate binding site; other site 956149001595 dimer interface; other site 956149001596 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 956149001597 homotrimer interaction site [polypeptide binding]; other site 956149001598 zinc binding site [ion binding]; other site 956149001599 CDP-binding sites; other site 956149001600 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 956149001601 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 956149001602 Permutation of conserved domain; other site 956149001603 active site 956149001604 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 956149001605 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 956149001606 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 956149001607 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 956149001608 S-adenosylmethionine binding site [chemical binding]; other site 956149001609 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 956149001610 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 956149001611 Peptidase family M23; Region: Peptidase_M23; pfam01551 956149001612 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 956149001613 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 956149001614 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 956149001615 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 956149001616 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 956149001617 DNA binding residues [nucleotide binding] 956149001618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 956149001619 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149001620 Major Facilitator Superfamily; Region: MFS_1; pfam07690 956149001621 putative substrate translocation pore; other site 956149001622 Transcriptional regulator [Transcription]; Region: LysR; COG0583 956149001623 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149001624 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 956149001625 putative effector binding pocket; other site 956149001626 dimerization interface [polypeptide binding]; other site 956149001627 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 956149001628 MarR family; Region: MarR_2; cl17246 956149001629 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 956149001630 Flavoprotein; Region: Flavoprotein; pfam02441 956149001631 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 956149001632 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 956149001633 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 956149001634 MutS domain I; Region: MutS_I; pfam01624 956149001635 MutS domain II; Region: MutS_II; pfam05188 956149001636 MutS domain III; Region: MutS_III; pfam05192 956149001637 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 956149001638 Walker A/P-loop; other site 956149001639 ATP binding site [chemical binding]; other site 956149001640 Q-loop/lid; other site 956149001641 ABC transporter signature motif; other site 956149001642 Walker B; other site 956149001643 D-loop; other site 956149001644 H-loop/switch region; other site 956149001645 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 956149001646 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 956149001647 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 956149001648 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 956149001649 dimer interface [polypeptide binding]; other site 956149001650 ligand binding site [chemical binding]; other site 956149001651 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 956149001652 dimerization interface [polypeptide binding]; other site 956149001653 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 956149001654 dimer interface [polypeptide binding]; other site 956149001655 putative CheW interface [polypeptide binding]; other site 956149001656 KTSC domain; Region: KTSC; pfam13619 956149001657 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 956149001658 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 956149001659 substrate binding pocket [chemical binding]; other site 956149001660 membrane-bound complex binding site; other site 956149001661 hinge residues; other site 956149001662 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 956149001663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149001664 dimer interface [polypeptide binding]; other site 956149001665 conserved gate region; other site 956149001666 putative PBP binding loops; other site 956149001667 ABC-ATPase subunit interface; other site 956149001668 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 956149001669 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 956149001670 Walker A/P-loop; other site 956149001671 ATP binding site [chemical binding]; other site 956149001672 Q-loop/lid; other site 956149001673 ABC transporter signature motif; other site 956149001674 Walker B; other site 956149001675 D-loop; other site 956149001676 H-loop/switch region; other site 956149001677 Transglycosylase SLT domain; Region: SLT_2; pfam13406 956149001678 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 956149001679 N-acetyl-D-glucosamine binding site [chemical binding]; other site 956149001680 hypothetical protein; Validated; Region: PRK03661 956149001681 recombinase A; Provisional; Region: recA; PRK09354 956149001682 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 956149001683 hexamer interface [polypeptide binding]; other site 956149001684 Walker A motif; other site 956149001685 ATP binding site [chemical binding]; other site 956149001686 Walker B motif; other site 956149001687 recombination regulator RecX; Reviewed; Region: recX; PRK00117 956149001688 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 956149001689 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 956149001690 motif 1; other site 956149001691 active site 956149001692 motif 2; other site 956149001693 motif 3; other site 956149001694 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 956149001695 DHHA1 domain; Region: DHHA1; pfam02272 956149001696 carbon storage regulator; Provisional; Region: PRK01712 956149001697 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 956149001698 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 956149001699 motif II; other site 956149001700 Predicted membrane protein [Function unknown]; Region: COG1238 956149001701 glutamate--cysteine ligase; Provisional; Region: PRK02107 956149001702 S-ribosylhomocysteinase; Provisional; Region: PRK02260 956149001703 CHASE4 domain; Region: CHASE4; pfam05228 956149001704 PAS domain S-box; Region: sensory_box; TIGR00229 956149001705 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 956149001706 putative active site [active] 956149001707 heme pocket [chemical binding]; other site 956149001708 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 956149001709 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 956149001710 metal binding site [ion binding]; metal-binding site 956149001711 active site 956149001712 I-site; other site 956149001713 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 956149001714 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 956149001715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149001716 putative substrate translocation pore; other site 956149001717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149001718 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 956149001719 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 956149001720 HlyD family secretion protein; Region: HlyD_3; pfam13437 956149001721 transcriptional repressor MprA; Provisional; Region: PRK10870 956149001722 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 956149001723 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 956149001724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149001725 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 956149001726 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 956149001727 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 956149001728 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149001729 dimer interface [polypeptide binding]; other site 956149001730 conserved gate region; other site 956149001731 putative PBP binding loops; other site 956149001732 ABC-ATPase subunit interface; other site 956149001733 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 956149001734 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 956149001735 Walker A/P-loop; other site 956149001736 ATP binding site [chemical binding]; other site 956149001737 Q-loop/lid; other site 956149001738 ABC transporter signature motif; other site 956149001739 Walker B; other site 956149001740 D-loop; other site 956149001741 H-loop/switch region; other site 956149001742 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 956149001743 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 956149001744 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 956149001745 dimer interface [polypeptide binding]; other site 956149001746 putative radical transfer pathway; other site 956149001747 diiron center [ion binding]; other site 956149001748 tyrosyl radical; other site 956149001749 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 956149001750 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 956149001751 Class I ribonucleotide reductase; Region: RNR_I; cd01679 956149001752 active site 956149001753 dimer interface [polypeptide binding]; other site 956149001754 catalytic residues [active] 956149001755 effector binding site; other site 956149001756 R2 peptide binding site; other site 956149001757 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 956149001758 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 956149001759 catalytic residues [active] 956149001760 hypothetical protein; Provisional; Region: PRK10132 956149001761 hypothetical protein; Provisional; Region: PRK10556 956149001762 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 956149001763 SAM (Sterile alpha motif ); Region: SAM_superfamily; cl15755 956149001764 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 956149001765 FIST N domain; Region: FIST; smart00897 956149001766 FIST C domain; Region: FIST_C; pfam10442 956149001767 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 956149001768 dimer interface [polypeptide binding]; other site 956149001769 putative CheW interface [polypeptide binding]; other site 956149001770 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 956149001771 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 956149001772 active site 956149001773 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 956149001774 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 956149001775 ATP binding site [chemical binding]; other site 956149001776 putative Mg++ binding site [ion binding]; other site 956149001777 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 956149001778 nucleotide binding region [chemical binding]; other site 956149001779 ATP-binding site [chemical binding]; other site 956149001780 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 956149001781 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 956149001782 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 956149001783 ATP binding site [chemical binding]; other site 956149001784 putative Mg++ binding site [ion binding]; other site 956149001785 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 956149001786 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 956149001787 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 956149001788 Protein of unknown function (DUF987); Region: DUF987; pfam06174 956149001789 hypothetical protein; Reviewed; Region: PRK00024 956149001790 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 956149001791 MPN+ (JAMM) motif; other site 956149001792 Zinc-binding site [ion binding]; other site 956149001793 Domain of unknown function (DUF932); Region: DUF932; pfam06067 956149001794 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 956149001795 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 956149001796 putative active site [active] 956149001797 putative NTP binding site [chemical binding]; other site 956149001798 putative nucleic acid binding site [nucleotide binding]; other site 956149001799 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 956149001800 HTH-like domain; Region: HTH_21; pfam13276 956149001801 Integrase core domain; Region: rve; pfam00665 956149001802 Integrase core domain; Region: rve_3; pfam13683 956149001803 Transposase; Region: HTH_Tnp_1; pfam01527 956149001804 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 956149001805 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 956149001806 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 956149001807 putative active site [active] 956149001808 putative metal-binding site [ion binding]; other site 956149001809 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 956149001810 WYL domain; Region: WYL; pfam13280 956149001811 hypothetical protein; Provisional; Region: PRK10236 956149001812 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 956149001813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 956149001814 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 956149001815 iron-sulfur cluster [ion binding]; other site 956149001816 [2Fe-2S] cluster binding site [ion binding]; other site 956149001817 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 956149001818 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 956149001819 MULE transposase domain; Region: MULE; pfam10551 956149001820 integrase; Provisional; Region: PRK09692 956149001821 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 956149001822 active site 956149001823 Int/Topo IB signature motif; other site 956149001824 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 956149001825 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 956149001826 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 956149001827 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 956149001828 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 956149001829 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 956149001830 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 956149001831 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 956149001832 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 956149001833 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 956149001834 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 956149001835 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 956149001836 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 956149001837 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 956149001838 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 956149001839 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 956149001840 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 956149001841 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 956149001842 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 956149001843 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 956149001844 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 956149001845 Walker A/P-loop; other site 956149001846 ATP binding site [chemical binding]; other site 956149001847 Q-loop/lid; other site 956149001848 ABC transporter signature motif; other site 956149001849 Walker B; other site 956149001850 D-loop; other site 956149001851 H-loop/switch region; other site 956149001852 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 956149001853 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 956149001854 HlyD family secretion protein; Region: HlyD_3; pfam13437 956149001855 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 956149001856 SmpB-tmRNA interface; other site 956149001857 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 956149001858 putative coenzyme Q binding site [chemical binding]; other site 956149001859 hypothetical protein; Validated; Region: PRK01777 956149001860 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 956149001861 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 956149001862 recombination and repair protein; Provisional; Region: PRK10869 956149001863 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 956149001864 Walker A/P-loop; other site 956149001865 ATP binding site [chemical binding]; other site 956149001866 Q-loop/lid; other site 956149001867 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 956149001868 Q-loop/lid; other site 956149001869 ABC transporter signature motif; other site 956149001870 Walker B; other site 956149001871 D-loop; other site 956149001872 H-loop/switch region; other site 956149001873 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 956149001874 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 956149001875 GrpE; Region: GrpE; pfam01025 956149001876 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 956149001877 dimer interface [polypeptide binding]; other site 956149001878 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 956149001879 hypothetical protein; Provisional; Region: PRK11573 956149001880 Domain of unknown function DUF21; Region: DUF21; pfam01595 956149001881 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 956149001882 Transporter associated domain; Region: CorC_HlyC; smart01091 956149001883 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 956149001884 signal recognition particle protein; Provisional; Region: PRK10867 956149001885 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 956149001886 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 956149001887 P loop; other site 956149001888 GTP binding site [chemical binding]; other site 956149001889 Signal peptide binding domain; Region: SRP_SPB; pfam02978 956149001890 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 956149001891 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 956149001892 RimM N-terminal domain; Region: RimM; pfam01782 956149001893 PRC-barrel domain; Region: PRC; pfam05239 956149001894 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 956149001895 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 956149001896 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 956149001897 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 956149001898 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 956149001899 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 956149001900 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 956149001901 Chorismate mutase type II; Region: CM_2; cl00693 956149001902 prephenate dehydrogenase; Validated; Region: PRK08507 956149001903 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 956149001904 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 956149001905 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 956149001906 Prephenate dehydratase; Region: PDT; pfam00800 956149001907 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 956149001908 putative L-Phe binding site [chemical binding]; other site 956149001909 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 956149001910 30S subunit binding site; other site 956149001911 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 956149001912 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 956149001913 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 956149001914 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 956149001915 RNA binding surface [nucleotide binding]; other site 956149001916 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 956149001917 active site 956149001918 hypothetical protein; Provisional; Region: PRK10723 956149001919 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 956149001920 protein disaggregation chaperone; Provisional; Region: PRK10865 956149001921 Clp amino terminal domain; Region: Clp_N; pfam02861 956149001922 Clp amino terminal domain; Region: Clp_N; pfam02861 956149001923 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 956149001924 Walker A motif; other site 956149001925 ATP binding site [chemical binding]; other site 956149001926 Walker B motif; other site 956149001927 arginine finger; other site 956149001928 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 956149001929 Walker A motif; other site 956149001930 ATP binding site [chemical binding]; other site 956149001931 Walker B motif; other site 956149001932 arginine finger; other site 956149001933 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 956149001934 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 956149001935 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 956149001936 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 956149001937 non-specific DNA binding site [nucleotide binding]; other site 956149001938 salt bridge; other site 956149001939 sequence-specific DNA binding site [nucleotide binding]; other site 956149001940 2TM domain; Region: 2TM; pfam13239 956149001941 thiamine pyrophosphate protein; Provisional; Region: PRK08273 956149001942 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 956149001943 PYR/PP interface [polypeptide binding]; other site 956149001944 dimer interface [polypeptide binding]; other site 956149001945 tetramer interface [polypeptide binding]; other site 956149001946 TPP binding site [chemical binding]; other site 956149001947 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 956149001948 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 956149001949 TPP-binding site [chemical binding]; other site 956149001950 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 956149001951 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 956149001952 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149001953 putative substrate translocation pore; other site 956149001954 lipoprotein; Provisional; Region: PRK10759 956149001955 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 956149001956 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 956149001957 domain interface [polypeptide binding]; other site 956149001958 putative active site [active] 956149001959 catalytic site [active] 956149001960 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 956149001961 domain interface [polypeptide binding]; other site 956149001962 putative active site [active] 956149001963 catalytic site [active] 956149001964 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 956149001965 CoA binding domain; Region: CoA_binding_2; pfam13380 956149001966 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 956149001967 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 956149001968 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 956149001969 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 956149001970 Uncharacterized conserved protein [Function unknown]; Region: COG3148 956149001971 thioredoxin 2; Provisional; Region: PRK10996 956149001972 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 956149001973 catalytic residues [active] 956149001974 putative methyltransferase; Provisional; Region: PRK10864 956149001975 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 956149001976 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 956149001977 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 956149001978 ligand binding site [chemical binding]; other site 956149001979 active site 956149001980 UGI interface [polypeptide binding]; other site 956149001981 catalytic site [active] 956149001982 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 956149001983 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 956149001984 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 956149001985 ATP binding site [chemical binding]; other site 956149001986 Mg++ binding site [ion binding]; other site 956149001987 motif III; other site 956149001988 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 956149001989 nucleotide binding region [chemical binding]; other site 956149001990 ATP-binding site [chemical binding]; other site 956149001991 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 956149001992 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 956149001993 S-adenosylmethionine binding site [chemical binding]; other site 956149001994 L-aspartate oxidase; Provisional; Region: PRK09077 956149001995 L-aspartate oxidase; Provisional; Region: PRK06175 956149001996 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 956149001997 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 956149001998 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 956149001999 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 956149002000 DNA binding residues [nucleotide binding] 956149002001 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 956149002002 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 956149002003 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 956149002004 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 956149002005 anti-sigma E factor; Provisional; Region: rseB; PRK09455 956149002006 SoxR reducing system protein RseC; Provisional; Region: PRK10862 956149002007 GTP-binding protein LepA; Provisional; Region: PRK05433 956149002008 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 956149002009 G1 box; other site 956149002010 putative GEF interaction site [polypeptide binding]; other site 956149002011 GTP/Mg2+ binding site [chemical binding]; other site 956149002012 Switch I region; other site 956149002013 G2 box; other site 956149002014 G3 box; other site 956149002015 Switch II region; other site 956149002016 G4 box; other site 956149002017 G5 box; other site 956149002018 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 956149002019 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 956149002020 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 956149002021 signal peptidase I; Provisional; Region: PRK10861 956149002022 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 956149002023 Catalytic site [active] 956149002024 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 956149002025 ribonuclease III; Reviewed; Region: rnc; PRK00102 956149002026 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 956149002027 dimerization interface [polypeptide binding]; other site 956149002028 active site 956149002029 metal binding site [ion binding]; metal-binding site 956149002030 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 956149002031 dsRNA binding site [nucleotide binding]; other site 956149002032 GTPase Era; Reviewed; Region: era; PRK00089 956149002033 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 956149002034 G1 box; other site 956149002035 GTP/Mg2+ binding site [chemical binding]; other site 956149002036 Switch I region; other site 956149002037 G2 box; other site 956149002038 Switch II region; other site 956149002039 G3 box; other site 956149002040 G4 box; other site 956149002041 G5 box; other site 956149002042 KH domain; Region: KH_2; pfam07650 956149002043 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 956149002044 Recombination protein O N terminal; Region: RecO_N; pfam11967 956149002045 Recombination protein O C terminal; Region: RecO_C; pfam02565 956149002046 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 956149002047 active site 956149002048 hydrophilic channel; other site 956149002049 dimerization interface [polypeptide binding]; other site 956149002050 catalytic residues [active] 956149002051 active site lid [active] 956149002052 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 956149002053 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 956149002054 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 956149002055 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 956149002056 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 956149002057 putative active site [active] 956149002058 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 956149002059 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 956149002060 putative active site [active] 956149002061 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 956149002062 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 956149002063 active site turn [active] 956149002064 phosphorylation site [posttranslational modification] 956149002065 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 956149002066 hypothetical protein; Provisional; Region: PRK11590 956149002067 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 956149002068 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 956149002069 nucleoside/Zn binding site; other site 956149002070 dimer interface [polypeptide binding]; other site 956149002071 catalytic motif [active] 956149002072 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 956149002073 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 956149002074 substrate binding pocket [chemical binding]; other site 956149002075 membrane-bound complex binding site; other site 956149002076 hinge residues; other site 956149002077 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 956149002078 N-acetyl-D-glucosamine binding site [chemical binding]; other site 956149002079 catalytic residue [active] 956149002080 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 956149002081 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 956149002082 dimerization interface [polypeptide binding]; other site 956149002083 ATP binding site [chemical binding]; other site 956149002084 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 956149002085 dimerization interface [polypeptide binding]; other site 956149002086 ATP binding site [chemical binding]; other site 956149002087 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 956149002088 putative active site [active] 956149002089 catalytic triad [active] 956149002090 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 956149002091 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 956149002092 dimer interface [polypeptide binding]; other site 956149002093 phosphorylation site [posttranslational modification] 956149002094 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 956149002095 ATP binding site [chemical binding]; other site 956149002096 Mg2+ binding site [ion binding]; other site 956149002097 G-X-G motif; other site 956149002098 hypothetical protein; Provisional; Region: PRK10722 956149002099 response regulator GlrR; Provisional; Region: PRK15115 956149002100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 956149002101 active site 956149002102 phosphorylation site [posttranslational modification] 956149002103 intermolecular recognition site; other site 956149002104 dimerization interface [polypeptide binding]; other site 956149002105 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 956149002106 Walker A motif; other site 956149002107 ATP binding site [chemical binding]; other site 956149002108 Walker B motif; other site 956149002109 arginine finger; other site 956149002110 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 956149002111 Nitrogen regulatory protein P-II; Region: P-II; smart00938 956149002112 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 956149002113 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 956149002114 heme-binding site [chemical binding]; other site 956149002115 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 956149002116 FAD binding pocket [chemical binding]; other site 956149002117 FAD binding motif [chemical binding]; other site 956149002118 phosphate binding motif [ion binding]; other site 956149002119 beta-alpha-beta structure motif; other site 956149002120 NAD binding pocket [chemical binding]; other site 956149002121 Heme binding pocket [chemical binding]; other site 956149002122 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 956149002123 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 956149002124 dimer interface [polypeptide binding]; other site 956149002125 active site 956149002126 glycine-pyridoxal phosphate binding site [chemical binding]; other site 956149002127 folate binding site [chemical binding]; other site 956149002128 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 956149002129 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 956149002130 DNA binding residues [nucleotide binding] 956149002131 putative dimer interface [polypeptide binding]; other site 956149002132 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 956149002133 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 956149002134 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149002135 putative substrate translocation pore; other site 956149002136 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 956149002137 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 956149002138 PRD domain; Region: PRD; pfam00874 956149002139 PRD domain; Region: PRD; pfam00874 956149002140 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 956149002141 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 956149002142 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 956149002143 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 956149002144 active site 956149002145 dimerization interface [polypeptide binding]; other site 956149002146 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 956149002147 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 956149002148 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 956149002149 Rrf2 family protein; Region: rrf2_super; TIGR00738 956149002150 cysteine desulfurase; Provisional; Region: PRK14012 956149002151 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 956149002152 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 956149002153 catalytic residue [active] 956149002154 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 956149002155 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 956149002156 trimerization site [polypeptide binding]; other site 956149002157 active site 956149002158 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 956149002159 co-chaperone HscB; Provisional; Region: hscB; PRK05014 956149002160 DnaJ domain; Region: DnaJ; pfam00226 956149002161 HSP70 interaction site [polypeptide binding]; other site 956149002162 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 956149002163 chaperone protein HscA; Provisional; Region: hscA; PRK05183 956149002164 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 956149002165 nucleotide binding site [chemical binding]; other site 956149002166 putative NEF/HSP70 interaction site [polypeptide binding]; other site 956149002167 SBD interface [polypeptide binding]; other site 956149002168 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 956149002169 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 956149002170 catalytic loop [active] 956149002171 iron binding site [ion binding]; other site 956149002172 hypothetical protein; Provisional; Region: PRK10721 956149002173 aminopeptidase B; Provisional; Region: PRK05015 956149002174 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 956149002175 interface (dimer of trimers) [polypeptide binding]; other site 956149002176 Substrate-binding/catalytic site; other site 956149002177 Zn-binding sites [ion binding]; other site 956149002178 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 956149002179 Peptidase family M48; Region: Peptidase_M48; cl12018 956149002180 Peptidase family M48; Region: Peptidase_M48; cl12018 956149002181 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 956149002182 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 956149002183 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 956149002184 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 956149002185 putative active site [active] 956149002186 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 956149002187 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 956149002188 active site residue [active] 956149002189 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 956149002190 active site residue [active] 956149002191 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 956149002192 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 956149002193 NAD binding site [chemical binding]; other site 956149002194 sugar binding site [chemical binding]; other site 956149002195 divalent metal binding site [ion binding]; other site 956149002196 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 956149002197 dimer interface [polypeptide binding]; other site 956149002198 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 956149002199 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 956149002200 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 956149002201 active site turn [active] 956149002202 phosphorylation site [posttranslational modification] 956149002203 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 956149002204 MG2 domain; Region: A2M_N; pfam01835 956149002205 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 956149002206 surface patch; other site 956149002207 thioester region; other site 956149002208 penicillin-binding protein 1C; Provisional; Region: PRK11240 956149002209 Transglycosylase; Region: Transgly; pfam00912 956149002210 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 956149002211 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 956149002212 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 956149002213 active site 956149002214 multimer interface [polypeptide binding]; other site 956149002215 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 956149002216 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 956149002217 FeS/SAM binding site; other site 956149002218 cytoskeletal protein RodZ; Provisional; Region: PRK10856 956149002219 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 956149002220 non-specific DNA binding site [nucleotide binding]; other site 956149002221 salt bridge; other site 956149002222 sequence-specific DNA binding site [nucleotide binding]; other site 956149002223 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 956149002224 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 956149002225 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 956149002226 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 956149002227 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 956149002228 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 956149002229 dimer interface [polypeptide binding]; other site 956149002230 motif 1; other site 956149002231 active site 956149002232 motif 2; other site 956149002233 motif 3; other site 956149002234 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 956149002235 anticodon binding site; other site 956149002236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 956149002237 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 956149002238 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 956149002239 Trp docking motif [polypeptide binding]; other site 956149002240 GTP-binding protein Der; Reviewed; Region: PRK00093 956149002241 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 956149002242 G1 box; other site 956149002243 GTP/Mg2+ binding site [chemical binding]; other site 956149002244 Switch I region; other site 956149002245 G2 box; other site 956149002246 Switch II region; other site 956149002247 G3 box; other site 956149002248 G4 box; other site 956149002249 G5 box; other site 956149002250 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 956149002251 G1 box; other site 956149002252 GTP/Mg2+ binding site [chemical binding]; other site 956149002253 Switch I region; other site 956149002254 G2 box; other site 956149002255 G3 box; other site 956149002256 Switch II region; other site 956149002257 G4 box; other site 956149002258 G5 box; other site 956149002259 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 956149002260 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 956149002261 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 956149002262 active site 956149002263 Zn binding site [ion binding]; other site 956149002264 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 956149002265 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 956149002266 generic binding surface II; other site 956149002267 generic binding surface I; other site 956149002268 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 956149002269 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 956149002270 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 956149002271 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 956149002272 active site 956149002273 GMP synthase; Reviewed; Region: guaA; PRK00074 956149002274 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 956149002275 AMP/PPi binding site [chemical binding]; other site 956149002276 candidate oxyanion hole; other site 956149002277 catalytic triad [active] 956149002278 potential glutamine specificity residues [chemical binding]; other site 956149002279 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 956149002280 ATP Binding subdomain [chemical binding]; other site 956149002281 Ligand Binding sites [chemical binding]; other site 956149002282 Dimerization subdomain; other site 956149002283 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 956149002284 MASE1; Region: MASE1; pfam05231 956149002285 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 956149002286 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 956149002287 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 956149002288 exopolyphosphatase; Provisional; Region: PRK10854 956149002289 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 956149002290 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 956149002291 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 956149002292 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 956149002293 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 956149002294 putative active site [active] 956149002295 catalytic site [active] 956149002296 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 956149002297 domain interface [polypeptide binding]; other site 956149002298 active site 956149002299 catalytic site [active] 956149002300 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 956149002301 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 956149002302 active site 956149002303 substrate binding site [chemical binding]; other site 956149002304 cosubstrate binding site; other site 956149002305 catalytic site [active] 956149002306 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 956149002307 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 956149002308 dimerization interface [polypeptide binding]; other site 956149002309 putative ATP binding site [chemical binding]; other site 956149002310 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 956149002311 active site 956149002312 uracil transporter; Provisional; Region: PRK10720 956149002313 DNA replication initiation factor; Provisional; Region: PRK08084 956149002314 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 956149002315 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 956149002316 ArsC family; Region: ArsC; pfam03960 956149002317 catalytic residues [active] 956149002318 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 956149002319 Peptidase family M48; Region: Peptidase_M48; cl12018 956149002320 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 956149002321 Domain of unknown function DUF20; Region: UPF0118; pfam01594 956149002322 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 956149002323 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 956149002324 catalytic triad [active] 956149002325 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 956149002326 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 956149002327 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 956149002328 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 956149002329 dihydrodipicolinate synthase; Region: dapA; TIGR00674 956149002330 dimer interface [polypeptide binding]; other site 956149002331 active site 956149002332 catalytic residue [active] 956149002333 lipoprotein; Provisional; Region: PRK11679 956149002334 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 956149002335 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 956149002336 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 956149002337 ATP binding site [chemical binding]; other site 956149002338 active site 956149002339 substrate binding site [chemical binding]; other site 956149002340 Predicted metalloprotease [General function prediction only]; Region: COG2321 956149002341 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 956149002342 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 956149002343 Helicase; Region: Helicase_RecD; pfam05127 956149002344 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 956149002345 Coenzyme A binding pocket [chemical binding]; other site 956149002346 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 956149002347 putative hydrolase; Provisional; Region: PRK11460 956149002348 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 956149002349 hypothetical protein; Provisional; Region: PRK13664 956149002350 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 956149002351 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 956149002352 metal binding site [ion binding]; metal-binding site 956149002353 dimer interface [polypeptide binding]; other site 956149002354 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 956149002355 ArsC family; Region: ArsC; pfam03960 956149002356 putative catalytic residues [active] 956149002357 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 956149002358 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 956149002359 Coenzyme A binding pocket [chemical binding]; other site 956149002360 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 956149002361 Protein export membrane protein; Region: SecD_SecF; cl14618 956149002362 transcriptional regulator NarP; Provisional; Region: PRK10403 956149002363 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 956149002364 active site 956149002365 phosphorylation site [posttranslational modification] 956149002366 intermolecular recognition site; other site 956149002367 dimerization interface [polypeptide binding]; other site 956149002368 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 956149002369 DNA binding residues [nucleotide binding] 956149002370 dimerization interface [polypeptide binding]; other site 956149002371 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 956149002372 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 956149002373 dimer interface [polypeptide binding]; other site 956149002374 ADP-ribose binding site [chemical binding]; other site 956149002375 active site 956149002376 nudix motif; other site 956149002377 metal binding site [ion binding]; metal-binding site 956149002378 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 956149002379 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 956149002380 transketolase; Reviewed; Region: PRK12753 956149002381 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 956149002382 TPP-binding site [chemical binding]; other site 956149002383 dimer interface [polypeptide binding]; other site 956149002384 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 956149002385 PYR/PP interface [polypeptide binding]; other site 956149002386 dimer interface [polypeptide binding]; other site 956149002387 TPP binding site [chemical binding]; other site 956149002388 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 956149002389 transaldolase-like protein; Provisional; Region: PTZ00411 956149002390 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 956149002391 active site 956149002392 dimer interface [polypeptide binding]; other site 956149002393 catalytic residue [active] 956149002394 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 956149002395 Malic enzyme, N-terminal domain; Region: malic; pfam00390 956149002396 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 956149002397 putative NAD(P) binding site [chemical binding]; other site 956149002398 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 956149002399 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 956149002400 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 956149002401 Walker A/P-loop; other site 956149002402 ATP binding site [chemical binding]; other site 956149002403 Q-loop/lid; other site 956149002404 ABC transporter signature motif; other site 956149002405 Walker B; other site 956149002406 D-loop; other site 956149002407 H-loop/switch region; other site 956149002408 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 956149002409 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 956149002410 ABC-ATPase subunit interface; other site 956149002411 dimer interface [polypeptide binding]; other site 956149002412 putative PBP binding regions; other site 956149002413 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 956149002414 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 956149002415 ABC-ATPase subunit interface; other site 956149002416 dimer interface [polypeptide binding]; other site 956149002417 putative PBP binding regions; other site 956149002418 enterobactin exporter EntS; Provisional; Region: PRK10489 956149002419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149002420 putative substrate translocation pore; other site 956149002421 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 956149002422 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 956149002423 siderophore binding site; other site 956149002424 isochorismate synthase EntC; Provisional; Region: PRK15016 956149002425 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 956149002426 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 956149002427 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 956149002428 acyl-activating enzyme (AAE) consensus motif; other site 956149002429 active site 956149002430 AMP binding site [chemical binding]; other site 956149002431 substrate binding site [chemical binding]; other site 956149002432 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 956149002433 hydrophobic substrate binding pocket; other site 956149002434 Isochorismatase family; Region: Isochorismatase; pfam00857 956149002435 active site 956149002436 conserved cis-peptide bond; other site 956149002437 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 956149002438 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 956149002439 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 956149002440 NAD(P) binding site [chemical binding]; other site 956149002441 active site 956149002442 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 956149002443 CoenzymeA binding site [chemical binding]; other site 956149002444 subunit interaction site [polypeptide binding]; other site 956149002445 PHB binding site; other site 956149002446 carbon starvation protein A; Provisional; Region: PRK15015 956149002447 Carbon starvation protein CstA; Region: CstA; pfam02554 956149002448 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 956149002449 Uncharacterized small protein [Function unknown]; Region: COG2879 956149002450 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 956149002451 salt bridge; other site 956149002452 non-specific DNA binding site [nucleotide binding]; other site 956149002453 sequence-specific DNA binding site [nucleotide binding]; other site 956149002454 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 956149002455 enterobactin exporter EntS; Provisional; Region: PRK10489 956149002456 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149002457 putative substrate translocation pore; other site 956149002458 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 956149002459 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 956149002460 putative active site [active] 956149002461 metal binding site [ion binding]; metal-binding site 956149002462 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 956149002463 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 956149002464 Walker A/P-loop; other site 956149002465 ATP binding site [chemical binding]; other site 956149002466 Q-loop/lid; other site 956149002467 ABC transporter signature motif; other site 956149002468 Walker B; other site 956149002469 D-loop; other site 956149002470 H-loop/switch region; other site 956149002471 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 956149002472 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 956149002473 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 956149002474 TM-ABC transporter signature motif; other site 956149002475 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 956149002476 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 956149002477 putative ligand binding site [chemical binding]; other site 956149002478 Uncharacterized conserved protein [Function unknown]; Region: COG5276 956149002479 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 956149002480 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 956149002481 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 956149002482 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 956149002483 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 956149002484 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 956149002485 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 956149002486 active site 956149002487 metal binding site [ion binding]; metal-binding site 956149002488 putative acetyltransferase; Provisional; Region: PRK03624 956149002489 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 956149002490 Coenzyme A binding pocket [chemical binding]; other site 956149002491 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 956149002492 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 956149002493 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 956149002494 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 956149002495 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 956149002496 thiosulfate transporter subunit; Provisional; Region: PRK10852 956149002497 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 956149002498 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 956149002499 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149002500 dimer interface [polypeptide binding]; other site 956149002501 conserved gate region; other site 956149002502 putative PBP binding loops; other site 956149002503 ABC-ATPase subunit interface; other site 956149002504 sulfate transport protein; Provisional; Region: cysT; CHL00187 956149002505 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149002506 dimer interface [polypeptide binding]; other site 956149002507 conserved gate region; other site 956149002508 putative PBP binding loops; other site 956149002509 ABC-ATPase subunit interface; other site 956149002510 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 956149002511 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 956149002512 Walker A/P-loop; other site 956149002513 ATP binding site [chemical binding]; other site 956149002514 Q-loop/lid; other site 956149002515 ABC transporter signature motif; other site 956149002516 Walker B; other site 956149002517 D-loop; other site 956149002518 H-loop/switch region; other site 956149002519 TOBE-like domain; Region: TOBE_3; pfam12857 956149002520 cysteine synthase B; Region: cysM; TIGR01138 956149002521 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 956149002522 dimer interface [polypeptide binding]; other site 956149002523 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149002524 catalytic residue [active] 956149002525 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 956149002526 HPr interaction site; other site 956149002527 glycerol kinase (GK) interaction site [polypeptide binding]; other site 956149002528 active site 956149002529 phosphorylation site [posttranslational modification] 956149002530 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 956149002531 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 956149002532 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 956149002533 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 956149002534 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 956149002535 dimerization domain swap beta strand [polypeptide binding]; other site 956149002536 regulatory protein interface [polypeptide binding]; other site 956149002537 active site 956149002538 regulatory phosphorylation site [posttranslational modification]; other site 956149002539 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 956149002540 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 956149002541 dimer interface [polypeptide binding]; other site 956149002542 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149002543 catalytic residue [active] 956149002544 putative sulfate transport protein CysZ; Validated; Region: PRK04949 956149002545 cell division protein ZipA; Provisional; Region: PRK03427 956149002546 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 956149002547 FtsZ protein binding site [polypeptide binding]; other site 956149002548 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 956149002549 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 956149002550 nucleotide binding pocket [chemical binding]; other site 956149002551 K-X-D-G motif; other site 956149002552 catalytic site [active] 956149002553 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 956149002554 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 956149002555 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 956149002556 Dimer interface [polypeptide binding]; other site 956149002557 BRCT sequence motif; other site 956149002558 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 956149002559 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 956149002560 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 956149002561 active site 956149002562 HIGH motif; other site 956149002563 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 956149002564 active site 956149002565 KMSKS motif; other site 956149002566 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 956149002567 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 956149002568 potential protein location (hypothetical protein CSSP291_04110 [Cronobacter sakazakii Sp291]) that overlaps RNA (tRNA-A) 956149002569 MASE1; Region: MASE1; cl17823 956149002570 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 956149002571 diguanylate cyclase; Region: GGDEF; smart00267 956149002572 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 956149002573 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 956149002574 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 956149002575 Nucleoside recognition; Region: Gate; pfam07670 956149002576 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 956149002577 manganese transport protein MntH; Reviewed; Region: PRK00701 956149002578 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 956149002579 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 956149002580 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 956149002581 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 956149002582 active site 956149002583 catalytic tetrad [active] 956149002584 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 956149002585 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 956149002586 dimer interface [polypeptide binding]; other site 956149002587 PYR/PP interface [polypeptide binding]; other site 956149002588 TPP binding site [chemical binding]; other site 956149002589 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 956149002590 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 956149002591 TPP-binding site [chemical binding]; other site 956149002592 dimer interface [polypeptide binding]; other site 956149002593 glucokinase, proteobacterial type; Region: glk; TIGR00749 956149002594 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 956149002595 nucleotide binding site [chemical binding]; other site 956149002596 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 956149002597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 956149002598 active site 956149002599 phosphorylation site [posttranslational modification] 956149002600 intermolecular recognition site; other site 956149002601 dimerization interface [polypeptide binding]; other site 956149002602 LytTr DNA-binding domain; Region: LytTR; pfam04397 956149002603 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 956149002604 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 956149002605 GAF domain; Region: GAF_3; pfam13492 956149002606 Histidine kinase; Region: His_kinase; pfam06580 956149002607 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 956149002608 ATP binding site [chemical binding]; other site 956149002609 Mg2+ binding site [ion binding]; other site 956149002610 G-X-G motif; other site 956149002611 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 956149002612 aminotransferase; Validated; Region: PRK08175 956149002613 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 956149002614 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149002615 homodimer interface [polypeptide binding]; other site 956149002616 catalytic residue [active] 956149002617 Cupin domain; Region: Cupin_2; pfam07883 956149002618 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 956149002619 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 956149002620 oligomer interface [polypeptide binding]; other site 956149002621 metal binding site [ion binding]; metal-binding site 956149002622 metal binding site [ion binding]; metal-binding site 956149002623 putative Cl binding site [ion binding]; other site 956149002624 basic sphincter; other site 956149002625 hydrophobic gate; other site 956149002626 periplasmic entrance; other site 956149002627 Transcriptional regulator [Transcription]; Region: LysR; COG0583 956149002628 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149002629 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 956149002630 putative dimerization interface [polypeptide binding]; other site 956149002631 putative substrate binding pocket [chemical binding]; other site 956149002632 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 956149002633 acetolactate synthase; Reviewed; Region: PRK08617 956149002634 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 956149002635 PYR/PP interface [polypeptide binding]; other site 956149002636 dimer interface [polypeptide binding]; other site 956149002637 TPP binding site [chemical binding]; other site 956149002638 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 956149002639 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 956149002640 TPP-binding site [chemical binding]; other site 956149002641 acetoin reductase; Validated; Region: PRK08643 956149002642 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 956149002643 NAD binding site [chemical binding]; other site 956149002644 homotetramer interface [polypeptide binding]; other site 956149002645 homodimer interface [polypeptide binding]; other site 956149002646 active site 956149002647 substrate binding site [chemical binding]; other site 956149002648 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 956149002649 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 956149002650 amphipathic channel; other site 956149002651 Asn-Pro-Ala signature motifs; other site 956149002652 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 956149002653 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 956149002654 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 956149002655 Protein of unknown function (DUF987); Region: DUF987; pfam06174 956149002656 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 956149002657 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 956149002658 MPN+ (JAMM) motif; other site 956149002659 Zinc-binding site [ion binding]; other site 956149002660 Antirestriction protein; Region: Antirestrict; pfam03230 956149002661 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 956149002662 Domain of unknown function (DUF932); Region: DUF932; pfam06067 956149002663 Predicted transcriptional regulator [Transcription]; Region: COG2378 956149002664 HTH domain; Region: HTH_11; pfam08279 956149002665 WYL domain; Region: WYL; pfam13280 956149002666 YfjP GTPase; Region: YfjP; cd11383 956149002667 G1 box; other site 956149002668 GTP/Mg2+ binding site [chemical binding]; other site 956149002669 Switch I region; other site 956149002670 G2 box; other site 956149002671 Switch II region; other site 956149002672 G3 box; other site 956149002673 G4 box; other site 956149002674 G5 box; other site 956149002675 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 956149002676 Transposase; Region: HTH_Tnp_1; pfam01527 956149002677 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 956149002678 HTH-like domain; Region: HTH_21; pfam13276 956149002679 Integrase core domain; Region: rve; pfam00665 956149002680 Integrase core domain; Region: rve_3; pfam13683 956149002681 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 956149002682 HTH-like domain; Region: HTH_21; pfam13276 956149002683 Integrase core domain; Region: rve; pfam00665 956149002684 Integrase core domain; Region: rve_2; pfam13333 956149002685 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 956149002686 Peptidase family M48; Region: Peptidase_M48; cl12018 956149002687 Phosphate-starvation-inducible E; Region: PsiE; pfam06146 956149002688 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 956149002689 Clp amino terminal domain; Region: Clp_N; pfam02861 956149002690 Clp amino terminal domain; Region: Clp_N; pfam02861 956149002691 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 956149002692 Walker A motif; other site 956149002693 ATP binding site [chemical binding]; other site 956149002694 Walker B motif; other site 956149002695 arginine finger; other site 956149002696 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 956149002697 Walker A motif; other site 956149002698 ATP binding site [chemical binding]; other site 956149002699 Walker B motif; other site 956149002700 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 956149002701 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 956149002702 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 956149002703 putative dimer interface [polypeptide binding]; other site 956149002704 Helix-turn-helix domain; Region: HTH_17; pfam12728 956149002705 Transposase; Region: HTH_Tnp_1; pfam01527 956149002706 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 956149002707 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 956149002708 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 956149002709 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 956149002710 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 956149002711 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 956149002712 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 956149002713 Maltose acetyltransferase; Region: Mac; pfam12464 956149002714 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 956149002715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149002716 putative substrate translocation pore; other site 956149002717 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 956149002718 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 956149002719 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 956149002720 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 956149002721 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 956149002722 lac repressor; Reviewed; Region: lacI; PRK09526 956149002723 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 956149002724 DNA binding site [nucleotide binding] 956149002725 domain linker motif; other site 956149002726 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 956149002727 ligand binding site [chemical binding]; other site 956149002728 dimerization interface (open form) [polypeptide binding]; other site 956149002729 dimerization interface (closed form) [polypeptide binding]; other site 956149002730 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 956149002731 Transposase; Region: HTH_Tnp_1; pfam01527 956149002732 integrase; Provisional; Region: PRK09692 956149002733 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 956149002734 active site 956149002735 Int/Topo IB signature motif; other site 956149002736 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 956149002737 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 956149002738 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 956149002739 Walker A/P-loop; other site 956149002740 ATP binding site [chemical binding]; other site 956149002741 Q-loop/lid; other site 956149002742 ABC transporter signature motif; other site 956149002743 Walker B; other site 956149002744 D-loop; other site 956149002745 H-loop/switch region; other site 956149002746 heme exporter protein CcmB; Region: ccmB; TIGR01190 956149002747 heme exporter protein CcmC; Region: ccmC; TIGR01191 956149002748 Heme exporter protein D (CcmD); Region: CcmD; cl11475 956149002749 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150 956149002750 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 956149002751 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 956149002752 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 956149002753 catalytic residues [active] 956149002754 central insert; other site 956149002755 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 956149002756 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 956149002757 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 956149002758 binding surface 956149002759 TPR motif; other site 956149002760 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 956149002761 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 956149002762 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 956149002763 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 956149002764 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 956149002765 dimer interface [polypeptide binding]; other site 956149002766 active site 956149002767 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 956149002768 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 956149002769 substrate binding site [chemical binding]; other site 956149002770 oxyanion hole (OAH) forming residues; other site 956149002771 trimer interface [polypeptide binding]; other site 956149002772 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 956149002773 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 956149002774 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 956149002775 catalytic core [active] 956149002776 hypothetical protein; Provisional; Region: PRK04946 956149002777 Smr domain; Region: Smr; pfam01713 956149002778 HemK family putative methylases; Region: hemK_fam; TIGR00536 956149002779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 956149002780 S-adenosylmethionine binding site [chemical binding]; other site 956149002781 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 956149002782 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 956149002783 Tetramer interface [polypeptide binding]; other site 956149002784 active site 956149002785 FMN-binding site [chemical binding]; other site 956149002786 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 956149002787 hypothetical protein; Provisional; Region: PRK10621 956149002788 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 956149002789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 956149002790 YfcL protein; Region: YfcL; pfam08891 956149002791 Uncharacterized conserved protein [Function unknown]; Region: COG4121 956149002792 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 956149002793 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 956149002794 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 956149002795 dimer interface [polypeptide binding]; other site 956149002796 active site 956149002797 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 956149002798 catalytic triad [active] 956149002799 putative active site [active] 956149002800 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 956149002801 Autotransporter beta-domain; Region: Autotransporter; smart00869 956149002802 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 956149002803 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 956149002804 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 956149002805 ligand binding site [chemical binding]; other site 956149002806 NAD binding site [chemical binding]; other site 956149002807 catalytic site [active] 956149002808 homodimer interface [polypeptide binding]; other site 956149002809 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 956149002810 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 956149002811 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 956149002812 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 956149002813 dimerization interface 3.5A [polypeptide binding]; other site 956149002814 active site 956149002815 hypothetical protein; Provisional; Region: PRK10847 956149002816 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 956149002817 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 956149002818 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 956149002819 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 956149002820 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 956149002821 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 956149002822 cell division protein DedD; Provisional; Region: PRK11633 956149002823 Sporulation related domain; Region: SPOR; pfam05036 956149002824 colicin V production protein; Provisional; Region: PRK10845 956149002825 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 956149002826 amidophosphoribosyltransferase; Provisional; Region: PRK09246 956149002827 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 956149002828 active site 956149002829 tetramer interface [polypeptide binding]; other site 956149002830 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 956149002831 active site 956149002832 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 956149002833 Flavoprotein; Region: Flavoprotein; pfam02441 956149002834 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 956149002835 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 956149002836 substrate binding pocket [chemical binding]; other site 956149002837 membrane-bound complex binding site; other site 956149002838 hinge residues; other site 956149002839 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 956149002840 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 956149002841 substrate binding pocket [chemical binding]; other site 956149002842 membrane-bound complex binding site; other site 956149002843 hinge residues; other site 956149002844 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 956149002845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149002846 dimer interface [polypeptide binding]; other site 956149002847 conserved gate region; other site 956149002848 putative PBP binding loops; other site 956149002849 ABC-ATPase subunit interface; other site 956149002850 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 956149002851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149002852 dimer interface [polypeptide binding]; other site 956149002853 conserved gate region; other site 956149002854 putative PBP binding loops; other site 956149002855 ABC-ATPase subunit interface; other site 956149002856 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 956149002857 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 956149002858 Walker A/P-loop; other site 956149002859 ATP binding site [chemical binding]; other site 956149002860 Q-loop/lid; other site 956149002861 ABC transporter signature motif; other site 956149002862 Walker B; other site 956149002863 D-loop; other site 956149002864 H-loop/switch region; other site 956149002865 RES domain; Region: RES; smart00953 956149002866 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 956149002867 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 956149002868 NAD(P) binding site [chemical binding]; other site 956149002869 active site 956149002870 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 956149002871 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 956149002872 C-terminal domain interface [polypeptide binding]; other site 956149002873 GSH binding site (G-site) [chemical binding]; other site 956149002874 dimer interface [polypeptide binding]; other site 956149002875 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 956149002876 N-terminal domain interface [polypeptide binding]; other site 956149002877 putative dimer interface [polypeptide binding]; other site 956149002878 active site 956149002879 glutathione S-transferase; Provisional; Region: PRK15113 956149002880 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 956149002881 C-terminal domain interface [polypeptide binding]; other site 956149002882 GSH binding site (G-site) [chemical binding]; other site 956149002883 dimer interface [polypeptide binding]; other site 956149002884 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 956149002885 N-terminal domain interface [polypeptide binding]; other site 956149002886 putative dimer interface [polypeptide binding]; other site 956149002887 putative substrate binding pocket (H-site) [chemical binding]; other site 956149002888 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 956149002889 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 956149002890 active site 956149002891 metal binding site [ion binding]; metal-binding site 956149002892 homotetramer interface [polypeptide binding]; other site 956149002893 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 956149002894 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 956149002895 nudix motif; other site 956149002896 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 956149002897 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 956149002898 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 956149002899 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 956149002900 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 956149002901 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 956149002902 phosphate acetyltransferase; Reviewed; Region: PRK05632 956149002903 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 956149002904 DRTGG domain; Region: DRTGG; pfam07085 956149002905 phosphate acetyltransferase; Region: pta; TIGR00651 956149002906 propionate/acetate kinase; Provisional; Region: PRK12379 956149002907 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 956149002908 hypothetical protein; Provisional; Region: PRK01816 956149002909 hypothetical protein; Validated; Region: PRK05445 956149002910 putative phosphatase; Provisional; Region: PRK11587 956149002911 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 956149002912 motif II; other site 956149002913 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 956149002914 transmembrane helices; other site 956149002915 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 956149002916 TrkA-C domain; Region: TrkA_C; pfam02080 956149002917 TrkA-C domain; Region: TrkA_C; pfam02080 956149002918 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 956149002919 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 956149002920 Zn2+ binding site [ion binding]; other site 956149002921 Mg2+ binding site [ion binding]; other site 956149002922 aminotransferase AlaT; Validated; Region: PRK09265 956149002923 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 956149002924 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149002925 homodimer interface [polypeptide binding]; other site 956149002926 catalytic residue [active] 956149002927 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 956149002928 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149002929 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 956149002930 putative dimerization interface [polypeptide binding]; other site 956149002931 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 956149002932 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 956149002933 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 956149002934 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 956149002935 NADH dehydrogenase subunit D; Validated; Region: PRK06075 956149002936 NADH dehydrogenase subunit E; Validated; Region: PRK07539 956149002937 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 956149002938 putative dimer interface [polypeptide binding]; other site 956149002939 [2Fe-2S] cluster binding site [ion binding]; other site 956149002940 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 956149002941 SLBB domain; Region: SLBB; pfam10531 956149002942 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 956149002943 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 956149002944 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 956149002945 catalytic loop [active] 956149002946 iron binding site [ion binding]; other site 956149002947 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 956149002948 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 956149002949 [4Fe-4S] binding site [ion binding]; other site 956149002950 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 956149002951 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 956149002952 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 956149002953 4Fe-4S binding domain; Region: Fer4; pfam00037 956149002954 4Fe-4S binding domain; Region: Fer4; pfam00037 956149002955 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 956149002956 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 956149002957 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 956149002958 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 956149002959 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 956149002960 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 956149002961 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 956149002962 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 956149002963 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 956149002964 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 956149002965 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 956149002966 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 956149002967 Coenzyme A binding pocket [chemical binding]; other site 956149002968 hypothetical protein; Provisional; Region: PRK10404 956149002969 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 956149002970 chorismate binding enzyme; Region: Chorismate_bind; cl10555 956149002971 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 956149002972 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 956149002973 dimer interface [polypeptide binding]; other site 956149002974 tetramer interface [polypeptide binding]; other site 956149002975 PYR/PP interface [polypeptide binding]; other site 956149002976 TPP binding site [chemical binding]; other site 956149002977 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 956149002978 TPP-binding site; other site 956149002979 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 956149002980 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 956149002981 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 956149002982 substrate binding site [chemical binding]; other site 956149002983 oxyanion hole (OAH) forming residues; other site 956149002984 trimer interface [polypeptide binding]; other site 956149002985 O-succinylbenzoate synthase; Provisional; Region: PRK05105 956149002986 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 956149002987 active site 956149002988 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 956149002989 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 956149002990 acyl-activating enzyme (AAE) consensus motif; other site 956149002991 putative AMP binding site [chemical binding]; other site 956149002992 putative active site [active] 956149002993 putative CoA binding site [chemical binding]; other site 956149002994 hypothetical protein; Provisional; Region: PRK09867 956149002995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 956149002996 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 956149002997 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 956149002998 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 956149002999 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 956149003000 active site 956149003001 phosphorylation site [posttranslational modification] 956149003002 intermolecular recognition site; other site 956149003003 dimerization interface [polypeptide binding]; other site 956149003004 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 956149003005 DNA binding site [nucleotide binding] 956149003006 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 956149003007 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 956149003008 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 956149003009 dimerization interface [polypeptide binding]; other site 956149003010 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 956149003011 dimer interface [polypeptide binding]; other site 956149003012 phosphorylation site [posttranslational modification] 956149003013 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 956149003014 ATP binding site [chemical binding]; other site 956149003015 G-X-G motif; other site 956149003016 YfaZ precursor; Region: YfaZ; pfam07437 956149003017 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 956149003018 hypothetical protein; Provisional; Region: PRK03673 956149003019 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 956149003020 putative MPT binding site; other site 956149003021 Competence-damaged protein; Region: CinA; cl00666 956149003022 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 956149003023 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149003024 putative substrate translocation pore; other site 956149003025 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 956149003026 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 956149003027 active site 956149003028 catalytic site [active] 956149003029 metal binding site [ion binding]; metal-binding site 956149003030 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 956149003031 catalytic loop [active] 956149003032 iron binding site [ion binding]; other site 956149003033 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 956149003034 dimer interface [polypeptide binding]; other site 956149003035 putative radical transfer pathway; other site 956149003036 diiron center [ion binding]; other site 956149003037 tyrosyl radical; other site 956149003038 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 956149003039 ATP cone domain; Region: ATP-cone; pfam03477 956149003040 Class I ribonucleotide reductase; Region: RNR_I; cd01679 956149003041 active site 956149003042 dimer interface [polypeptide binding]; other site 956149003043 catalytic residues [active] 956149003044 effector binding site; other site 956149003045 R2 peptide binding site; other site 956149003046 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 956149003047 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 956149003048 S-adenosylmethionine binding site [chemical binding]; other site 956149003049 DNA gyrase subunit A; Validated; Region: PRK05560 956149003050 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 956149003051 CAP-like domain; other site 956149003052 active site 956149003053 primary dimer interface [polypeptide binding]; other site 956149003054 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 956149003055 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 956149003056 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 956149003057 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 956149003058 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 956149003059 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 956149003060 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 956149003061 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 956149003062 dimer interface [polypeptide binding]; other site 956149003063 phosphorylation site [posttranslational modification] 956149003064 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 956149003065 ATP binding site [chemical binding]; other site 956149003066 Mg2+ binding site [ion binding]; other site 956149003067 G-X-G motif; other site 956149003068 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 956149003069 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 956149003070 active site 956149003071 phosphorylation site [posttranslational modification] 956149003072 intermolecular recognition site; other site 956149003073 dimerization interface [polypeptide binding]; other site 956149003074 transcriptional regulator RcsB; Provisional; Region: PRK10840 956149003075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 956149003076 active site 956149003077 phosphorylation site [posttranslational modification] 956149003078 intermolecular recognition site; other site 956149003079 dimerization interface [polypeptide binding]; other site 956149003080 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 956149003081 DNA binding residues [nucleotide binding] 956149003082 dimerization interface [polypeptide binding]; other site 956149003083 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 956149003084 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 956149003085 ATP binding site [chemical binding]; other site 956149003086 Mg2+ binding site [ion binding]; other site 956149003087 G-X-G motif; other site 956149003088 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 956149003089 putative binding surface; other site 956149003090 active site 956149003091 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 956149003092 outer membrane porin protein C; Provisional; Region: PRK10554 956149003093 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 956149003094 ApbE family; Region: ApbE; pfam02424 956149003095 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 956149003096 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 956149003097 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 956149003098 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 956149003099 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 956149003100 DNA binding site [nucleotide binding] 956149003101 active site 956149003102 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 956149003103 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 956149003104 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 956149003105 Walker A/P-loop; other site 956149003106 ATP binding site [chemical binding]; other site 956149003107 Q-loop/lid; other site 956149003108 ABC transporter signature motif; other site 956149003109 Walker B; other site 956149003110 D-loop; other site 956149003111 H-loop/switch region; other site 956149003112 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 956149003113 high affinity sulphate transporter 1; Region: sulP; TIGR00815 956149003114 Sulfate transporter family; Region: Sulfate_transp; pfam00916 956149003115 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 956149003116 KTSC domain; Region: KTSC; pfam13619 956149003117 putative chaperone protein EcpD; Provisional; Region: PRK09926 956149003118 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 956149003119 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 956149003120 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 956149003121 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 956149003122 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 956149003123 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 956149003124 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 956149003125 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 956149003126 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 956149003127 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 956149003128 transcriptional regulator SpvR; Provisional; Region: PRK15243 956149003129 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149003130 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 956149003131 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 956149003132 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 956149003133 Sulfatase; Region: Sulfatase; cl17466 956149003134 hypothetical protein; Provisional; Region: PRK13689 956149003135 Nucleoid-associated protein [General function prediction only]; Region: COG3081 956149003136 nucleoid-associated protein NdpA; Validated; Region: PRK00378 956149003137 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 956149003138 5S rRNA interface [nucleotide binding]; other site 956149003139 CTC domain interface [polypeptide binding]; other site 956149003140 L16 interface [polypeptide binding]; other site 956149003141 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 956149003142 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 956149003143 ATP binding site [chemical binding]; other site 956149003144 putative Mg++ binding site [ion binding]; other site 956149003145 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 956149003146 nucleotide binding region [chemical binding]; other site 956149003147 ATP-binding site [chemical binding]; other site 956149003148 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 956149003149 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 956149003150 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 956149003151 RNA binding surface [nucleotide binding]; other site 956149003152 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 956149003153 active site 956149003154 uracil binding [chemical binding]; other site 956149003155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149003156 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 956149003157 putative substrate translocation pore; other site 956149003158 hypothetical protein; Provisional; Region: PRK11835 956149003159 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 956149003160 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 956149003161 Walker A/P-loop; other site 956149003162 ATP binding site [chemical binding]; other site 956149003163 Q-loop/lid; other site 956149003164 ABC transporter signature motif; other site 956149003165 Walker B; other site 956149003166 D-loop; other site 956149003167 H-loop/switch region; other site 956149003168 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 956149003169 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 956149003170 Walker A/P-loop; other site 956149003171 ATP binding site [chemical binding]; other site 956149003172 Q-loop/lid; other site 956149003173 ABC transporter signature motif; other site 956149003174 Walker B; other site 956149003175 D-loop; other site 956149003176 H-loop/switch region; other site 956149003177 microcin C ABC transporter permease; Provisional; Region: PRK15021 956149003178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149003179 dimer interface [polypeptide binding]; other site 956149003180 conserved gate region; other site 956149003181 ABC-ATPase subunit interface; other site 956149003182 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 956149003183 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149003184 dimer interface [polypeptide binding]; other site 956149003185 conserved gate region; other site 956149003186 putative PBP binding loops; other site 956149003187 ABC-ATPase subunit interface; other site 956149003188 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 956149003189 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 956149003190 phage resistance protein; Provisional; Region: PRK10551 956149003191 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 956149003192 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 956149003193 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 956149003194 NlpC/P60 family; Region: NLPC_P60; pfam00877 956149003195 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 956149003196 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 956149003197 active site 956149003198 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 956149003199 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 956149003200 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 956149003201 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 956149003202 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 956149003203 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 956149003204 mannonate dehydratase; Provisional; Region: PRK03906 956149003205 mannonate dehydratase; Region: uxuA; TIGR00695 956149003206 elongation factor P; Provisional; Region: PRK04542 956149003207 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 956149003208 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 956149003209 RNA binding site [nucleotide binding]; other site 956149003210 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 956149003211 RNA binding site [nucleotide binding]; other site 956149003212 Flagellin N-methylase; Region: FliB; cl00497 956149003213 sugar efflux transporter B; Provisional; Region: PRK15011 956149003214 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149003215 putative substrate translocation pore; other site 956149003216 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 956149003217 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 956149003218 active site 956149003219 phosphorylation site [posttranslational modification] 956149003220 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 956149003221 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 956149003222 dimerization domain swap beta strand [polypeptide binding]; other site 956149003223 regulatory protein interface [polypeptide binding]; other site 956149003224 active site 956149003225 regulatory phosphorylation site [posttranslational modification]; other site 956149003226 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 956149003227 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 956149003228 putative substrate binding site [chemical binding]; other site 956149003229 putative ATP binding site [chemical binding]; other site 956149003230 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 956149003231 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 956149003232 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 956149003233 active site 956149003234 P-loop; other site 956149003235 phosphorylation site [posttranslational modification] 956149003236 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 956149003237 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 956149003238 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 956149003239 endonuclease IV; Provisional; Region: PRK01060 956149003240 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 956149003241 AP (apurinic/apyrimidinic) site pocket; other site 956149003242 DNA interaction; other site 956149003243 Metal-binding active site; metal-binding site 956149003244 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 956149003245 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 956149003246 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149003247 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 956149003248 putative dimerization interface [polypeptide binding]; other site 956149003249 lysine transporter; Provisional; Region: PRK10836 956149003250 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 956149003251 S-formylglutathione hydrolase; Region: PLN02442 956149003252 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 956149003253 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 956149003254 GTP cyclohydrolase I; Provisional; Region: PLN03044 956149003255 active site 956149003256 Predicted membrane protein [Function unknown]; Region: COG2311 956149003257 hypothetical protein; Provisional; Region: PRK10835 956149003258 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 956149003259 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 956149003260 DNA binding site [nucleotide binding] 956149003261 domain linker motif; other site 956149003262 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 956149003263 dimerization interface (closed form) [polypeptide binding]; other site 956149003264 ligand binding site [chemical binding]; other site 956149003265 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 956149003266 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 956149003267 ligand binding site [chemical binding]; other site 956149003268 calcium binding site [ion binding]; other site 956149003269 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 956149003270 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 956149003271 Walker A/P-loop; other site 956149003272 ATP binding site [chemical binding]; other site 956149003273 Q-loop/lid; other site 956149003274 ABC transporter signature motif; other site 956149003275 Walker B; other site 956149003276 D-loop; other site 956149003277 H-loop/switch region; other site 956149003278 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 956149003279 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 956149003280 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 956149003281 TM-ABC transporter signature motif; other site 956149003282 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 956149003283 putative active site [active] 956149003284 cytidine deaminase; Provisional; Region: PRK09027 956149003285 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 956149003286 active site 956149003287 catalytic motif [active] 956149003288 Zn binding site [ion binding]; other site 956149003289 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 956149003290 active site 956149003291 catalytic motif [active] 956149003292 Zn binding site [ion binding]; other site 956149003293 hypothetical protein; Provisional; Region: PRK10711 956149003294 hypothetical protein; Provisional; Region: PRK01821 956149003295 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 956149003296 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 956149003297 non-specific DNA binding site [nucleotide binding]; other site 956149003298 salt bridge; other site 956149003299 sequence-specific DNA binding site [nucleotide binding]; other site 956149003300 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 956149003301 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 956149003302 FMN binding site [chemical binding]; other site 956149003303 active site 956149003304 catalytic residues [active] 956149003305 substrate binding site [chemical binding]; other site 956149003306 Transcriptional regulator [Transcription]; Region: LysR; COG0583 956149003307 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149003308 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 956149003309 putative substrate binding pocket [chemical binding]; other site 956149003310 putative dimerization interface [polypeptide binding]; other site 956149003311 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 956149003312 oxidoreductase; Provisional; Region: PRK12743 956149003313 classical (c) SDRs; Region: SDR_c; cd05233 956149003314 NAD(P) binding site [chemical binding]; other site 956149003315 active site 956149003316 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 956149003317 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 956149003318 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 956149003319 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 956149003320 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 956149003321 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 956149003322 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 956149003323 Coenzyme A binding pocket [chemical binding]; other site 956149003324 D-lactate dehydrogenase; Provisional; Region: PRK11183 956149003325 FAD binding domain; Region: FAD_binding_4; pfam01565 956149003326 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 956149003327 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 956149003328 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 956149003329 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 956149003330 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 956149003331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149003332 dimer interface [polypeptide binding]; other site 956149003333 conserved gate region; other site 956149003334 ABC-ATPase subunit interface; other site 956149003335 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 956149003336 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 956149003337 Walker A/P-loop; other site 956149003338 ATP binding site [chemical binding]; other site 956149003339 Q-loop/lid; other site 956149003340 ABC transporter signature motif; other site 956149003341 Walker B; other site 956149003342 D-loop; other site 956149003343 H-loop/switch region; other site 956149003344 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149003345 putative PBP binding loops; other site 956149003346 ABC-ATPase subunit interface; other site 956149003347 hypothetical protein; Provisional; Region: PRK13681 956149003348 transcriptional regulator MirA; Provisional; Region: PRK15043 956149003349 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 956149003350 DNA binding residues [nucleotide binding] 956149003351 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 956149003352 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 956149003353 active site 956149003354 HIGH motif; other site 956149003355 KMSKS motif; other site 956149003356 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 956149003357 tRNA binding surface [nucleotide binding]; other site 956149003358 anticodon binding site; other site 956149003359 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 956149003360 dimer interface [polypeptide binding]; other site 956149003361 putative tRNA-binding site [nucleotide binding]; other site 956149003362 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 956149003363 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 956149003364 HlyD family secretion protein; Region: HlyD_3; pfam13437 956149003365 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 956149003366 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 956149003367 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 956149003368 FtsX-like permease family; Region: FtsX; pfam02687 956149003369 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 956149003370 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 956149003371 Walker A/P-loop; other site 956149003372 ATP binding site [chemical binding]; other site 956149003373 Q-loop/lid; other site 956149003374 ABC transporter signature motif; other site 956149003375 Walker B; other site 956149003376 D-loop; other site 956149003377 H-loop/switch region; other site 956149003378 antiporter inner membrane protein; Provisional; Region: PRK11670 956149003379 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 956149003380 Walker A motif; other site 956149003381 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 956149003382 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 956149003383 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 956149003384 Coenzyme A binding pocket [chemical binding]; other site 956149003385 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 956149003386 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 956149003387 GAF domain; Region: GAF_3; pfam13492 956149003388 Histidine kinase; Region: His_kinase; pfam06580 956149003389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 956149003390 ATP binding site [chemical binding]; other site 956149003391 Mg2+ binding site [ion binding]; other site 956149003392 G-X-G motif; other site 956149003393 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 956149003394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 956149003395 active site 956149003396 phosphorylation site [posttranslational modification] 956149003397 intermolecular recognition site; other site 956149003398 dimerization interface [polypeptide binding]; other site 956149003399 LytTr DNA-binding domain; Region: LytTR; pfam04397 956149003400 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 956149003401 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 956149003402 dimer interface [polypeptide binding]; other site 956149003403 ligand binding site [chemical binding]; other site 956149003404 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 956149003405 dimerization interface [polypeptide binding]; other site 956149003406 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 956149003407 dimer interface [polypeptide binding]; other site 956149003408 putative CheW interface [polypeptide binding]; other site 956149003409 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 956149003410 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 956149003411 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 956149003412 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 956149003413 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 956149003414 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 956149003415 substrate binding site [chemical binding]; other site 956149003416 multimerization interface [polypeptide binding]; other site 956149003417 ATP binding site [chemical binding]; other site 956149003418 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 956149003419 dimer interface [polypeptide binding]; other site 956149003420 substrate binding site [chemical binding]; other site 956149003421 ATP binding site [chemical binding]; other site 956149003422 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 956149003423 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 956149003424 putative active site; other site 956149003425 catalytic residue [active] 956149003426 lipid kinase; Reviewed; Region: PRK13054 956149003427 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 956149003428 putative protease; Provisional; Region: PRK15452 956149003429 Peptidase family U32; Region: Peptidase_U32; pfam01136 956149003430 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 956149003431 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 956149003432 active site 956149003433 phosphorylation site [posttranslational modification] 956149003434 intermolecular recognition site; other site 956149003435 dimerization interface [polypeptide binding]; other site 956149003436 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 956149003437 DNA binding site [nucleotide binding] 956149003438 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 956149003439 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 956149003440 dimerization interface [polypeptide binding]; other site 956149003441 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 956149003442 dimer interface [polypeptide binding]; other site 956149003443 phosphorylation site [posttranslational modification] 956149003444 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 956149003445 ATP binding site [chemical binding]; other site 956149003446 Mg2+ binding site [ion binding]; other site 956149003447 G-X-G motif; other site 956149003448 putative transporter; Provisional; Region: PRK10504 956149003449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149003450 putative substrate translocation pore; other site 956149003451 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 956149003452 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 956149003453 Protein export membrane protein; Region: SecD_SecF; cl14618 956149003454 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 956149003455 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 956149003456 HlyD family secretion protein; Region: HlyD_3; pfam13437 956149003457 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 956149003458 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 956149003459 salt bridge; other site 956149003460 non-specific DNA binding site [nucleotide binding]; other site 956149003461 sequence-specific DNA binding site [nucleotide binding]; other site 956149003462 putative chaperone; Provisional; Region: PRK11678 956149003463 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 956149003464 nucleotide binding site [chemical binding]; other site 956149003465 putative NEF/HSP70 interaction site [polypeptide binding]; other site 956149003466 SBD interface [polypeptide binding]; other site 956149003467 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 956149003468 AlkA N-terminal domain; Region: AlkA_N; pfam06029 956149003469 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 956149003470 minor groove reading motif; other site 956149003471 helix-hairpin-helix signature motif; other site 956149003472 substrate binding pocket [chemical binding]; other site 956149003473 active site 956149003474 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 956149003475 putative diguanylate cyclase; Provisional; Region: PRK09776 956149003476 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 956149003477 putative active site [active] 956149003478 heme pocket [chemical binding]; other site 956149003479 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 956149003480 putative active site [active] 956149003481 heme pocket [chemical binding]; other site 956149003482 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 956149003483 putative active site [active] 956149003484 heme pocket [chemical binding]; other site 956149003485 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 956149003486 metal binding site [ion binding]; metal-binding site 956149003487 active site 956149003488 I-site; other site 956149003489 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 956149003490 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 956149003491 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 956149003492 ATP-binding site [chemical binding]; other site 956149003493 Sugar specificity; other site 956149003494 Pyrimidine base specificity; other site 956149003495 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 956149003496 trimer interface [polypeptide binding]; other site 956149003497 active site 956149003498 putative assembly protein; Provisional; Region: PRK10833 956149003499 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 956149003500 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 956149003501 FOG: CBS domain [General function prediction only]; Region: COG0517 956149003502 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 956149003503 Transporter associated domain; Region: CorC_HlyC; smart01091 956149003504 polysaccharide export protein Wza; Provisional; Region: PRK15078 956149003505 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 956149003506 SLBB domain; Region: SLBB; pfam10531 956149003507 Low molecular weight phosphatase family; Region: LMWPc; cd00115 956149003508 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 956149003509 active site 956149003510 tyrosine kinase; Provisional; Region: PRK11519 956149003511 Chain length determinant protein; Region: Wzz; pfam02706 956149003512 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 956149003513 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 956149003514 putative glycosyl transferase; Provisional; Region: PRK10018 956149003515 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 956149003516 active site 956149003517 putative acyl transferase; Provisional; Region: PRK10191 956149003518 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 956149003519 trimer interface [polypeptide binding]; other site 956149003520 active site 956149003521 substrate binding site [chemical binding]; other site 956149003522 CoA binding site [chemical binding]; other site 956149003523 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 956149003524 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 956149003525 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 956149003526 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 956149003527 putative glycosyl transferase; Provisional; Region: PRK10063 956149003528 active site 956149003529 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 956149003530 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 956149003531 putative trimer interface [polypeptide binding]; other site 956149003532 putative active site [active] 956149003533 putative substrate binding site [chemical binding]; other site 956149003534 putative CoA binding site [chemical binding]; other site 956149003535 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 956149003536 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 956149003537 NADP-binding site; other site 956149003538 homotetramer interface [polypeptide binding]; other site 956149003539 substrate binding site [chemical binding]; other site 956149003540 homodimer interface [polypeptide binding]; other site 956149003541 active site 956149003542 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 956149003543 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 956149003544 NADP binding site [chemical binding]; other site 956149003545 active site 956149003546 putative substrate binding site [chemical binding]; other site 956149003547 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 956149003548 active site 956149003549 GDP-Mannose binding site [chemical binding]; other site 956149003550 dimer interface [polypeptide binding]; other site 956149003551 modified nudix motif 956149003552 metal binding site [ion binding]; metal-binding site 956149003553 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 956149003554 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 956149003555 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 956149003556 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 956149003557 Substrate binding site; other site 956149003558 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 956149003559 phosphomannomutase CpsG; Provisional; Region: PRK15414 956149003560 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 956149003561 active site 956149003562 substrate binding site [chemical binding]; other site 956149003563 metal binding site [ion binding]; metal-binding site 956149003564 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 956149003565 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 956149003566 colanic acid exporter; Provisional; Region: PRK10459 956149003567 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 956149003568 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 956149003569 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 956149003570 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 956149003571 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 956149003572 putative ADP-binding pocket [chemical binding]; other site 956149003573 colanic acid biosynthesis protein WcaM; Region: WcaM; TIGR04004 956149003574 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 956149003575 active site 956149003576 tetramer interface; other site 956149003577 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 956149003578 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 956149003579 NAD binding site [chemical binding]; other site 956149003580 substrate binding site [chemical binding]; other site 956149003581 homodimer interface [polypeptide binding]; other site 956149003582 active site 956149003583 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 956149003584 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 956149003585 NADP binding site [chemical binding]; other site 956149003586 active site 956149003587 putative substrate binding site [chemical binding]; other site 956149003588 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 956149003589 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 956149003590 substrate binding site; other site 956149003591 tetramer interface; other site 956149003592 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 956149003593 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 956149003594 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 956149003595 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 956149003596 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 956149003597 active site 956149003598 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 956149003599 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 956149003600 active site 956149003601 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 956149003602 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 956149003603 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 956149003604 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 956149003605 chain length determinant protein WzzB; Provisional; Region: PRK15471 956149003606 Chain length determinant protein; Region: Wzz; pfam02706 956149003607 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 956149003608 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 956149003609 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 956149003610 metal binding site [ion binding]; metal-binding site 956149003611 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 956149003612 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 956149003613 substrate binding site [chemical binding]; other site 956149003614 glutamase interaction surface [polypeptide binding]; other site 956149003615 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 956149003616 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 956149003617 catalytic residues [active] 956149003618 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 956149003619 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 956149003620 putative active site [active] 956149003621 oxyanion strand; other site 956149003622 catalytic triad [active] 956149003623 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 956149003624 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 956149003625 active site 956149003626 motif I; other site 956149003627 motif II; other site 956149003628 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 956149003629 putative active site pocket [active] 956149003630 4-fold oligomerization interface [polypeptide binding]; other site 956149003631 metal binding residues [ion binding]; metal-binding site 956149003632 3-fold/trimer interface [polypeptide binding]; other site 956149003633 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 956149003634 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 956149003635 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149003636 homodimer interface [polypeptide binding]; other site 956149003637 catalytic residue [active] 956149003638 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 956149003639 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 956149003640 NAD binding site [chemical binding]; other site 956149003641 dimerization interface [polypeptide binding]; other site 956149003642 product binding site; other site 956149003643 substrate binding site [chemical binding]; other site 956149003644 zinc binding site [ion binding]; other site 956149003645 catalytic residues [active] 956149003646 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 956149003647 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 956149003648 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 956149003649 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 956149003650 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 956149003651 putative NAD(P) binding site [chemical binding]; other site 956149003652 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 956149003653 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 956149003654 catalytic triad [active] 956149003655 4-aminobutyrate aminotransferase; Provisional; Region: PRK07495 956149003656 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 956149003657 inhibitor-cofactor binding pocket; inhibition site 956149003658 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149003659 catalytic residue [active] 956149003660 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 956149003661 exonuclease I; Provisional; Region: sbcB; PRK11779 956149003662 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 956149003663 active site 956149003664 catalytic site [active] 956149003665 substrate binding site [chemical binding]; other site 956149003666 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 956149003667 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 956149003668 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 956149003669 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 956149003670 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 956149003671 DNA gyrase inhibitor; Provisional; Region: PRK10016 956149003672 Predicted membrane protein [Function unknown]; Region: COG1289 956149003673 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 956149003674 hypothetical protein; Provisional; Region: PRK05423 956149003675 MATE family multidrug exporter; Provisional; Region: PRK10189 956149003676 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 956149003677 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 956149003678 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 956149003679 AMP nucleosidase; Provisional; Region: PRK08292 956149003680 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 956149003681 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 956149003682 Sensors of blue-light using FAD; Region: BLUF; smart01034 956149003683 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 956149003684 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 956149003685 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 956149003686 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 956149003687 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149003688 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 956149003689 putative dimerization interface [polypeptide binding]; other site 956149003690 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 956149003691 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 956149003692 dimerization interface [polypeptide binding]; other site 956149003693 shikimate transporter; Provisional; Region: PRK09952 956149003694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149003695 putative substrate translocation pore; other site 956149003696 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 956149003697 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 956149003698 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 956149003699 metal binding site [ion binding]; metal-binding site 956149003700 active site 956149003701 I-site; other site 956149003702 Transcriptional regulator [Transcription]; Region: LysR; COG0583 956149003703 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149003704 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 956149003705 putative effector binding pocket; other site 956149003706 dimerization interface [polypeptide binding]; other site 956149003707 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 956149003708 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 956149003709 potential catalytic triad [active] 956149003710 conserved cys residue [active] 956149003711 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 956149003712 classical (c) SDRs; Region: SDR_c; cd05233 956149003713 NAD(P) binding site [chemical binding]; other site 956149003714 active site 956149003715 DinI-like family; Region: DinI; pfam06183 956149003716 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 956149003717 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 956149003718 trimer interface [polypeptide binding]; other site 956149003719 eyelet of channel; other site 956149003720 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 956149003721 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 956149003722 Zn2+ binding site [ion binding]; other site 956149003723 Mg2+ binding site [ion binding]; other site 956149003724 DNA cytosine methylase; Provisional; Region: PRK10458 956149003725 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 956149003726 cofactor binding site; other site 956149003727 DNA binding site [nucleotide binding] 956149003728 substrate interaction site [chemical binding]; other site 956149003729 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 956149003730 additional DNA contacts [nucleotide binding]; other site 956149003731 mismatch recognition site; other site 956149003732 active site 956149003733 zinc binding site [ion binding]; other site 956149003734 DNA intercalation site [nucleotide binding]; other site 956149003735 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 956149003736 EamA-like transporter family; Region: EamA; pfam00892 956149003737 EamA-like transporter family; Region: EamA; pfam00892 956149003738 hypothetical protein; Provisional; Region: PRK10062 956149003739 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 956149003740 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 956149003741 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 956149003742 metal binding site [ion binding]; metal-binding site 956149003743 active site 956149003744 I-site; other site 956149003745 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 956149003746 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 956149003747 active site 956149003748 motif I; other site 956149003749 motif II; other site 956149003750 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 956149003751 hypothetical protein; Provisional; Region: PRK10708 956149003752 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 956149003753 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 956149003754 DNA binding residues [nucleotide binding] 956149003755 dimerization interface [polypeptide binding]; other site 956149003756 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 956149003757 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 956149003758 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 956149003759 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 956149003760 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 956149003761 flagellar motor switch protein; Validated; Region: fliN; PRK05698 956149003762 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 956149003763 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 956149003764 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 956149003765 flagellar hook-length control protein; Provisional; Region: PRK10118 956149003766 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 956149003767 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 956149003768 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 956149003769 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 956149003770 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 956149003771 Walker A motif/ATP binding site; other site 956149003772 Walker B motif; other site 956149003773 flagellar assembly protein H; Validated; Region: fliH; PRK05687 956149003774 Flagellar assembly protein FliH; Region: FliH; pfam02108 956149003775 flagellar motor switch protein FliG; Region: fliG; TIGR00207 956149003776 FliG C-terminal domain; Region: FliG_C; pfam01706 956149003777 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 956149003778 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 956149003779 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 956149003780 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 956149003781 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 956149003782 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 956149003783 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 956149003784 Int/Topo IB signature motif; other site 956149003785 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 956149003786 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 956149003787 non-specific DNA binding site [nucleotide binding]; other site 956149003788 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 956149003789 salt bridge; other site 956149003790 sequence-specific DNA binding site [nucleotide binding]; other site 956149003791 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 956149003792 Catalytic site [active] 956149003793 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 956149003794 non-specific DNA binding site [nucleotide binding]; other site 956149003795 salt bridge; other site 956149003796 sequence-specific DNA binding site [nucleotide binding]; other site 956149003797 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 956149003798 Helix-turn-helix domain; Region: HTH_36; pfam13730 956149003799 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 956149003800 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 956149003801 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 956149003802 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 956149003803 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 956149003804 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 956149003805 Protein of unknown function (DUF968); Region: DUF968; pfam06147 956149003806 Antitermination protein; Region: Antiterm; pfam03589 956149003807 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 956149003808 Protein of unknown function (DUF754); Region: DUF754; pfam05449 956149003809 Predicted chitinase [General function prediction only]; Region: COG3179 956149003810 catalytic residue [active] 956149003811 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 956149003812 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 956149003813 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 956149003814 active site 956149003815 Phage terminase, small subunit; Region: Terminase_4; pfam05119 956149003816 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 956149003817 Phage-related protein [Function unknown]; Region: COG4695 956149003818 Phage portal protein; Region: Phage_portal; pfam04860 956149003819 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 956149003820 oligomer interface [polypeptide binding]; other site 956149003821 active site residues [active] 956149003822 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 956149003823 Phage capsid family; Region: Phage_capsid; pfam05065 956149003824 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 956149003825 oligomerization interface [polypeptide binding]; other site 956149003826 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 956149003827 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 956149003828 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 956149003829 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 956149003830 Phage-related minor tail protein [Function unknown]; Region: COG5281 956149003831 tape measure domain; Region: tape_meas_nterm; TIGR02675 956149003832 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 956149003833 phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541 956149003834 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 956149003835 Phage minor tail protein; Region: Phage_min_tail; pfam05939 956149003836 Phage-related protein [Function unknown]; Region: gp18; COG4672 956149003837 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 956149003838 MPN+ (JAMM) motif; other site 956149003839 Zinc-binding site [ion binding]; other site 956149003840 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 956149003841 NlpC/P60 family; Region: NLPC_P60; cl17555 956149003842 Phage-related protein, tail component [Function unknown]; Region: COG4723 956149003843 Phage-related protein, tail component [Function unknown]; Region: COG4733 956149003844 Putative phage tail protein; Region: Phage-tail_3; pfam13550 956149003845 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 956149003846 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 956149003847 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 956149003848 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 956149003849 Catalytic site [active] 956149003850 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 956149003851 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 956149003852 active site 956149003853 DNA binding site [nucleotide binding] 956149003854 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 956149003855 Restriction endonuclease; Region: Mrr_cat; pfam04471 956149003856 Uncharacterized protein conserved in bacteria (DUF2251); Region: DUF2251; pfam10008 956149003857 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 956149003858 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 956149003859 putative active site [active] 956149003860 putative NTP binding site [chemical binding]; other site 956149003861 putative nucleic acid binding site [nucleotide binding]; other site 956149003862 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 956149003863 Catalytic site [active] 956149003864 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 956149003865 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 956149003866 active site 956149003867 DNA binding site [nucleotide binding] 956149003868 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 956149003869 Uncharacterized protein conserved in bacteria (DUF2251); Region: DUF2251; pfam10008 956149003870 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 956149003871 Helix-turn-helix domain; Region: HTH_31; pfam13560 956149003872 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 956149003873 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 956149003874 putative NAD(P) binding site [chemical binding]; other site 956149003875 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 956149003876 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 956149003877 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149003878 putative substrate translocation pore; other site 956149003879 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149003880 transcriptional activator TtdR; Provisional; Region: PRK09801 956149003881 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 956149003882 putative effector binding pocket; other site 956149003883 dimerization interface [polypeptide binding]; other site 956149003884 Methyltransferase domain; Region: Methyltransf_23; pfam13489 956149003885 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 956149003886 S-adenosylmethionine binding site [chemical binding]; other site 956149003887 hypothetical protein; Provisional; Region: PRK09951 956149003888 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 956149003889 CPxP motif; other site 956149003890 putative inner membrane protein; Provisional; Region: PRK11099 956149003891 lipoprotein; Provisional; Region: PRK10397 956149003892 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 956149003893 flagellar protein FliS; Validated; Region: fliS; PRK05685 956149003894 flagellar capping protein; Reviewed; Region: fliD; PRK08032 956149003895 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 956149003896 flagellin; Provisional; Region: PRK12802 956149003897 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 956149003898 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 956149003899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 956149003900 S-adenosylmethionine binding site [chemical binding]; other site 956149003901 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 956149003902 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 956149003903 binding surface 956149003904 TPR motif; other site 956149003905 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 956149003906 binding surface 956149003907 TPR motif; other site 956149003908 TPR repeat; Region: TPR_11; pfam13414 956149003909 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 956149003910 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 956149003911 inhibitor-cofactor binding pocket; inhibition site 956149003912 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149003913 catalytic residue [active] 956149003914 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 956149003915 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 956149003916 putative trimer interface [polypeptide binding]; other site 956149003917 putative CoA binding site [chemical binding]; other site 956149003918 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 956149003919 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 956149003920 NAD(P) binding site [chemical binding]; other site 956149003921 active site 956149003922 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 956149003923 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 956149003924 NAD(P) binding site [chemical binding]; other site 956149003925 active site 956149003926 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 956149003927 TPP-binding site [chemical binding]; other site 956149003928 dimer interface [polypeptide binding]; other site 956149003929 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 956149003930 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 956149003931 PYR/PP interface [polypeptide binding]; other site 956149003932 dimer interface [polypeptide binding]; other site 956149003933 TPP binding site [chemical binding]; other site 956149003934 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 956149003935 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 956149003936 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 956149003937 AMP binding site [chemical binding]; other site 956149003938 active site 956149003939 acyl-activating enzyme (AAE) consensus motif; other site 956149003940 CoA binding site [chemical binding]; other site 956149003941 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 956149003942 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 956149003943 NAD(P) binding site [chemical binding]; other site 956149003944 catalytic residues [active] 956149003945 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 956149003946 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 956149003947 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 956149003948 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 956149003949 DNA binding residues [nucleotide binding] 956149003950 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 956149003951 cystine transporter subunit; Provisional; Region: PRK11260 956149003952 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 956149003953 substrate binding pocket [chemical binding]; other site 956149003954 membrane-bound complex binding site; other site 956149003955 hinge residues; other site 956149003956 D-cysteine desulfhydrase; Validated; Region: PRK03910 956149003957 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 956149003958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149003959 catalytic residue [active] 956149003960 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 956149003961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149003962 dimer interface [polypeptide binding]; other site 956149003963 conserved gate region; other site 956149003964 putative PBP binding loops; other site 956149003965 ABC-ATPase subunit interface; other site 956149003966 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 956149003967 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 956149003968 Walker A/P-loop; other site 956149003969 ATP binding site [chemical binding]; other site 956149003970 Q-loop/lid; other site 956149003971 ABC transporter signature motif; other site 956149003972 Walker B; other site 956149003973 D-loop; other site 956149003974 H-loop/switch region; other site 956149003975 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 956149003976 Autoinducer binding domain; Region: Autoind_bind; pfam03472 956149003977 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 956149003978 DNA binding residues [nucleotide binding] 956149003979 dimerization interface [polypeptide binding]; other site 956149003980 hypothetical protein; Provisional; Region: PRK10613 956149003981 response regulator; Provisional; Region: PRK09483 956149003982 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 956149003983 active site 956149003984 phosphorylation site [posttranslational modification] 956149003985 intermolecular recognition site; other site 956149003986 dimerization interface [polypeptide binding]; other site 956149003987 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 956149003988 DNA binding residues [nucleotide binding] 956149003989 dimerization interface [polypeptide binding]; other site 956149003990 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 956149003991 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 956149003992 GIY-YIG motif/motif A; other site 956149003993 active site 956149003994 catalytic site [active] 956149003995 putative DNA binding site [nucleotide binding]; other site 956149003996 metal binding site [ion binding]; metal-binding site 956149003997 UvrB/uvrC motif; Region: UVR; pfam02151 956149003998 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 956149003999 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 956149004000 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 956149004001 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 956149004002 Coenzyme A binding pocket [chemical binding]; other site 956149004003 tyrosine transporter TyrP; Provisional; Region: PRK15132 956149004004 aromatic amino acid transport protein; Region: araaP; TIGR00837 956149004005 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 956149004006 Ferritin-like domain; Region: Ferritin; pfam00210 956149004007 ferroxidase diiron center [ion binding]; other site 956149004008 YecR-like lipoprotein; Region: YecR; pfam13992 956149004009 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 956149004010 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 956149004011 dimer interface [polypeptide binding]; other site 956149004012 putative CheW interface [polypeptide binding]; other site 956149004013 hypothetical protein; Provisional; Region: PRK09273 956149004014 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 956149004015 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 956149004016 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149004017 Major Facilitator Superfamily; Region: MFS_1; pfam07690 956149004018 putative substrate translocation pore; other site 956149004019 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 956149004020 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 956149004021 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 956149004022 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 956149004023 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 956149004024 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 956149004025 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 956149004026 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 956149004027 Ferritin-like domain; Region: Ferritin; pfam00210 956149004028 ferroxidase diiron center [ion binding]; other site 956149004029 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 956149004030 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 956149004031 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 956149004032 ligand binding site [chemical binding]; other site 956149004033 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 956149004034 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 956149004035 Walker A/P-loop; other site 956149004036 ATP binding site [chemical binding]; other site 956149004037 Q-loop/lid; other site 956149004038 ABC transporter signature motif; other site 956149004039 Walker B; other site 956149004040 D-loop; other site 956149004041 H-loop/switch region; other site 956149004042 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 956149004043 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 956149004044 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 956149004045 TM-ABC transporter signature motif; other site 956149004046 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 956149004047 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 956149004048 active site 956149004049 motif I; other site 956149004050 motif II; other site 956149004051 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 956149004052 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 956149004053 active site 956149004054 homotetramer interface [polypeptide binding]; other site 956149004055 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 956149004056 Ligand Binding Site [chemical binding]; other site 956149004057 transcriptional activator FlhD; Provisional; Region: PRK02909 956149004058 transcriptional activator FlhC; Provisional; Region: PRK12722 956149004059 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 956149004060 flagellar motor protein MotA; Validated; Region: PRK09110 956149004061 flagellar motor protein MotB; Validated; Region: motB; PRK09041 956149004062 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 956149004063 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 956149004064 ligand binding site [chemical binding]; other site 956149004065 chemotaxis protein CheA; Provisional; Region: PRK10547 956149004066 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 956149004067 putative binding surface; other site 956149004068 active site 956149004069 CheY binding; Region: CheY-binding; pfam09078 956149004070 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 956149004071 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 956149004072 ATP binding site [chemical binding]; other site 956149004073 Mg2+ binding site [ion binding]; other site 956149004074 G-X-G motif; other site 956149004075 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 956149004076 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 956149004077 putative CheA interaction surface; other site 956149004078 Spore Coat Protein U domain; Region: SCPU; pfam05229 956149004079 Spore Coat Protein U domain; Region: SCPU; pfam05229 956149004080 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 956149004081 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 956149004082 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 956149004083 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 956149004084 PapC C-terminal domain; Region: PapC_C; pfam13953 956149004085 Spore Coat Protein U domain; Region: SCPU; pfam05229 956149004086 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 956149004087 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 956149004088 dimer interface [polypeptide binding]; other site 956149004089 ligand binding site [chemical binding]; other site 956149004090 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 956149004091 dimerization interface [polypeptide binding]; other site 956149004092 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 956149004093 dimer interface [polypeptide binding]; other site 956149004094 putative CheW interface [polypeptide binding]; other site 956149004095 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 956149004096 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 956149004097 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 956149004098 S-adenosylmethionine binding site [chemical binding]; other site 956149004099 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 956149004100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 956149004101 active site 956149004102 phosphorylation site [posttranslational modification] 956149004103 intermolecular recognition site; other site 956149004104 dimerization interface [polypeptide binding]; other site 956149004105 CheB methylesterase; Region: CheB_methylest; pfam01339 956149004106 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 956149004107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 956149004108 active site 956149004109 phosphorylation site [posttranslational modification] 956149004110 intermolecular recognition site; other site 956149004111 dimerization interface [polypeptide binding]; other site 956149004112 chemotaxis regulator CheZ; Provisional; Region: PRK11166 956149004113 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK12468 956149004114 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 956149004115 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 956149004116 FHIPEP family; Region: FHIPEP; pfam00771 956149004117 Flagellar protein FlhE; Region: FlhE; pfam06366 956149004118 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 956149004119 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149004120 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 956149004121 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 956149004122 ligand binding site [chemical binding]; other site 956149004123 flexible hinge region; other site 956149004124 Transcriptional regulator; Region: Rrf2; cl17282 956149004125 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 956149004126 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 956149004127 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 956149004128 active site 956149004129 HIGH motif; other site 956149004130 KMSK motif region; other site 956149004131 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 956149004132 tRNA binding surface [nucleotide binding]; other site 956149004133 anticodon binding site; other site 956149004134 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 956149004135 putative metal binding site [ion binding]; other site 956149004136 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 956149004137 putative hydrophobic ligand binding site [chemical binding]; other site 956149004138 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 956149004139 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 956149004140 NAD binding site [chemical binding]; other site 956149004141 catalytic Zn binding site [ion binding]; other site 956149004142 structural Zn binding site [ion binding]; other site 956149004143 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 956149004144 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 956149004145 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149004146 homodimer interface [polypeptide binding]; other site 956149004147 catalytic residue [active] 956149004148 copper homeostasis protein CutC; Provisional; Region: PRK11572 956149004149 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 956149004150 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 956149004151 nucleotide binding site [chemical binding]; other site 956149004152 putative NEF/HSP70 interaction site [polypeptide binding]; other site 956149004153 SBD interface [polypeptide binding]; other site 956149004154 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 956149004155 HSP70 interaction site [polypeptide binding]; other site 956149004156 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 956149004157 BON domain; Region: BON; pfam04972 956149004158 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 956149004159 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 956149004160 S-adenosylmethionine binding site [chemical binding]; other site 956149004161 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 956149004162 S-adenosylmethionine binding site [chemical binding]; other site 956149004163 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 956149004164 hypothetical protein; Provisional; Region: PRK10302 956149004165 Isochorismatase family; Region: Isochorismatase; pfam00857 956149004166 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 956149004167 catalytic triad [active] 956149004168 conserved cis-peptide bond; other site 956149004169 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 956149004170 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 956149004171 dimer interface [polypeptide binding]; other site 956149004172 anticodon binding site; other site 956149004173 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 956149004174 homodimer interface [polypeptide binding]; other site 956149004175 motif 1; other site 956149004176 active site 956149004177 motif 2; other site 956149004178 GAD domain; Region: GAD; pfam02938 956149004179 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 956149004180 active site 956149004181 motif 3; other site 956149004182 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 956149004183 nudix motif; other site 956149004184 hypothetical protein; Validated; Region: PRK00110 956149004185 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 956149004186 active site 956149004187 putative DNA-binding cleft [nucleotide binding]; other site 956149004188 dimer interface [polypeptide binding]; other site 956149004189 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 956149004190 RuvA N terminal domain; Region: RuvA_N; pfam01330 956149004191 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 956149004192 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 956149004193 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 956149004194 Walker A motif; other site 956149004195 ATP binding site [chemical binding]; other site 956149004196 Walker B motif; other site 956149004197 arginine finger; other site 956149004198 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 956149004199 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 956149004200 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 956149004201 ABC-ATPase subunit interface; other site 956149004202 dimer interface [polypeptide binding]; other site 956149004203 putative PBP binding regions; other site 956149004204 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 956149004205 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 956149004206 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 956149004207 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 956149004208 metal binding site [ion binding]; metal-binding site 956149004209 putative peptidase; Provisional; Region: PRK11649 956149004210 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 956149004211 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 956149004212 Peptidase family M23; Region: Peptidase_M23; pfam01551 956149004213 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 956149004214 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 956149004215 putative acyl-acceptor binding pocket; other site 956149004216 pyruvate kinase; Provisional; Region: PRK05826 956149004217 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 956149004218 domain interfaces; other site 956149004219 active site 956149004220 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 956149004221 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 956149004222 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 956149004223 putative active site [active] 956149004224 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 956149004225 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 956149004226 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 956149004227 phosphogluconate dehydratase; Validated; Region: PRK09054 956149004228 6-phosphogluconate dehydratase; Region: edd; TIGR01196 956149004229 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 956149004230 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 956149004231 active site 956149004232 intersubunit interface [polypeptide binding]; other site 956149004233 catalytic residue [active] 956149004234 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 956149004235 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 956149004236 ATP-grasp domain; Region: ATP-grasp; pfam02222 956149004237 YebG protein; Region: YebG; pfam07130 956149004238 hypothetical protein; Provisional; Region: PRK13680 956149004239 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 956149004240 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 956149004241 putative metal binding site [ion binding]; other site 956149004242 protease 2; Provisional; Region: PRK10115 956149004243 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 956149004244 exodeoxyribonuclease X; Provisional; Region: PRK07983 956149004245 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 956149004246 active site 956149004247 catalytic site [active] 956149004248 substrate binding site [chemical binding]; other site 956149004249 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 956149004250 CopC domain; Region: CopC; cl01012 956149004251 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 956149004252 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 956149004253 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 956149004254 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 956149004255 active site 956149004256 metal binding site [ion binding]; metal-binding site 956149004257 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 956149004258 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 956149004259 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 956149004260 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 956149004261 S-adenosylmethionine binding site [chemical binding]; other site 956149004262 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 956149004263 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 956149004264 mce related protein; Region: MCE; pfam02470 956149004265 mce related protein; Region: MCE; pfam02470 956149004266 mce related protein; Region: MCE; pfam02470 956149004267 mce related protein; Region: MCE; pfam02470 956149004268 mce related protein; Region: MCE; pfam02470 956149004269 mce related protein; Region: MCE; pfam02470 956149004270 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 956149004271 Paraquat-inducible protein A; Region: PqiA; pfam04403 956149004272 Paraquat-inducible protein A; Region: PqiA; pfam04403 956149004273 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 956149004274 GAF domain; Region: GAF_2; pfam13185 956149004275 ProP expression regulator; Provisional; Region: PRK04950 956149004276 ProQ/FINO family; Region: ProQ; pfam04352 956149004277 carboxy-terminal protease; Provisional; Region: PRK11186 956149004278 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 956149004279 protein binding site [polypeptide binding]; other site 956149004280 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 956149004281 Catalytic dyad [active] 956149004282 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 956149004283 heat shock protein HtpX; Provisional; Region: PRK05457 956149004284 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 956149004285 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 956149004286 dimerization interface [polypeptide binding]; other site 956149004287 putative Zn2+ binding site [ion binding]; other site 956149004288 putative DNA binding site [nucleotide binding]; other site 956149004289 Bacterial transcriptional regulator; Region: IclR; pfam01614 956149004290 YobH-like protein; Region: YobH; pfam13996 956149004291 PhoPQ regulatory protein; Provisional; Region: PRK10299 956149004292 YebO-like protein; Region: YebO; pfam13974 956149004293 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 956149004294 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 956149004295 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 956149004296 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 956149004297 DNA-binding site [nucleotide binding]; DNA binding site 956149004298 RNA-binding motif; other site 956149004299 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 956149004300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 956149004301 S-adenosylmethionine binding site [chemical binding]; other site 956149004302 hypothetical protein; Provisional; Region: PRK11469 956149004303 Domain of unknown function DUF; Region: DUF204; pfam02659 956149004304 Domain of unknown function DUF; Region: DUF204; pfam02659 956149004305 hypothetical protein; Provisional; Region: PRK02913 956149004306 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 956149004307 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 956149004308 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 956149004309 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 956149004310 active pocket/dimerization site; other site 956149004311 active site 956149004312 phosphorylation site [posttranslational modification] 956149004313 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 956149004314 active site 956149004315 phosphorylation site [posttranslational modification] 956149004316 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 956149004317 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 956149004318 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 956149004319 Transporter associated domain; Region: CorC_HlyC; smart01091 956149004320 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 956149004321 phage resistance protein; Provisional; Region: PRK10551 956149004322 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 956149004323 L-serine deaminase; Provisional; Region: PRK15023 956149004324 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 956149004325 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 956149004326 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 956149004327 putative active site [active] 956149004328 putative CoA binding site [chemical binding]; other site 956149004329 nudix motif; other site 956149004330 metal binding site [ion binding]; metal-binding site 956149004331 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 956149004332 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 956149004333 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 956149004334 hypothetical protein; Provisional; Region: PRK05114 956149004335 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 956149004336 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 956149004337 dimer interface [polypeptide binding]; other site 956149004338 active site 956149004339 CoA binding pocket [chemical binding]; other site 956149004340 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 956149004341 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 956149004342 NAD(P) binding site [chemical binding]; other site 956149004343 active site 956149004344 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 956149004345 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 956149004346 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 956149004347 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 956149004348 active site 956149004349 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 956149004350 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 956149004351 Fatty acid desaturase; Region: FA_desaturase; pfam00487 956149004352 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 956149004353 putative di-iron ligands [ion binding]; other site 956149004354 Fatty acid desaturase; Region: FA_desaturase; pfam00487 956149004355 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 956149004356 putative di-iron ligands [ion binding]; other site 956149004357 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 956149004358 homotrimer interaction site [polypeptide binding]; other site 956149004359 putative active site [active] 956149004360 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 956149004361 DEAD/DEAH box helicase; Region: DEAD; pfam00270 956149004362 ATP binding site [chemical binding]; other site 956149004363 DEAD_2; Region: DEAD_2; pfam06733 956149004364 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 956149004365 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 956149004366 Glycoprotease family; Region: Peptidase_M22; pfam00814 956149004367 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 956149004368 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 956149004369 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 956149004370 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 956149004371 acyl-activating enzyme (AAE) consensus motif; other site 956149004372 putative AMP binding site [chemical binding]; other site 956149004373 putative active site [active] 956149004374 putative CoA binding site [chemical binding]; other site 956149004375 ribonuclease D; Provisional; Region: PRK10829 956149004376 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 956149004377 catalytic site [active] 956149004378 putative active site [active] 956149004379 putative substrate binding site [chemical binding]; other site 956149004380 HRDC domain; Region: HRDC; pfam00570 956149004381 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 956149004382 cell division inhibitor MinD; Provisional; Region: PRK10818 956149004383 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 956149004384 Switch I; other site 956149004385 Switch II; other site 956149004386 septum formation inhibitor; Reviewed; Region: minC; PRK03511 956149004387 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 956149004388 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 956149004389 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 956149004390 hypothetical protein; Provisional; Region: PRK10691 956149004391 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 956149004392 hypothetical protein; Provisional; Region: PRK05170 956149004393 disulfide bond formation protein B; Provisional; Region: PRK01749 956149004394 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 956149004395 transmembrane helices; other site 956149004396 fatty acid metabolism regulator; Provisional; Region: PRK04984 956149004397 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 956149004398 DNA-binding site [nucleotide binding]; DNA binding site 956149004399 FadR C-terminal domain; Region: FadR_C; pfam07840 956149004400 SpoVR family protein; Provisional; Region: PRK11767 956149004401 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 956149004402 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 956149004403 hydroxyglutarate oxidase; Provisional; Region: PRK11728 956149004404 alanine racemase; Reviewed; Region: dadX; PRK03646 956149004405 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 956149004406 active site 956149004407 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 956149004408 substrate binding site [chemical binding]; other site 956149004409 catalytic residues [active] 956149004410 dimer interface [polypeptide binding]; other site 956149004411 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 956149004412 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 956149004413 TrkA-C domain; Region: TrkA_C; pfam02080 956149004414 Transporter associated domain; Region: CorC_HlyC; smart01091 956149004415 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 956149004416 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 956149004417 dimer interface [polypeptide binding]; other site 956149004418 catalytic triad [active] 956149004419 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 956149004420 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 956149004421 N-acetyl-D-glucosamine binding site [chemical binding]; other site 956149004422 catalytic residue [active] 956149004423 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 956149004424 Flagellar regulator YcgR; Region: YcgR; pfam07317 956149004425 PilZ domain; Region: PilZ; pfam07238 956149004426 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 956149004427 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 956149004428 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 956149004429 N-terminal plug; other site 956149004430 ligand-binding site [chemical binding]; other site 956149004431 trehalase; Provisional; Region: treA; PRK13271 956149004432 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 956149004433 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 956149004434 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 956149004435 DNA-binding site [nucleotide binding]; DNA binding site 956149004436 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 956149004437 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149004438 homodimer interface [polypeptide binding]; other site 956149004439 catalytic residue [active] 956149004440 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 956149004441 Uncharacterized conserved protein [Function unknown]; Region: COG2128 956149004442 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 956149004443 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 956149004444 potential frameshift: common BLAST hit: gi|389840716|ref|YP_006342800.1| NAD(P)H oxidoreductase 956149004445 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 956149004446 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 956149004447 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 956149004448 hypothetical protein; Provisional; Region: PRK10396 956149004449 yecA family protein; Region: ygfB_yecA; TIGR02292 956149004450 SEC-C motif; Region: SEC-C; pfam02810 956149004451 GTP-binding protein YchF; Reviewed; Region: PRK09601 956149004452 YchF GTPase; Region: YchF; cd01900 956149004453 G1 box; other site 956149004454 GTP/Mg2+ binding site [chemical binding]; other site 956149004455 Switch I region; other site 956149004456 G2 box; other site 956149004457 Switch II region; other site 956149004458 G3 box; other site 956149004459 G4 box; other site 956149004460 G5 box; other site 956149004461 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 956149004462 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 956149004463 putative active site [active] 956149004464 catalytic residue [active] 956149004465 hypothetical protein; Provisional; Region: PRK10692 956149004466 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 956149004467 DNA binding residues [nucleotide binding] 956149004468 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 956149004469 putative dimer interface [polypeptide binding]; other site 956149004470 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 956149004471 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 956149004472 putative transporter; Provisional; Region: PRK11660 956149004473 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 956149004474 Sulfate transporter family; Region: Sulfate_transp; pfam00916 956149004475 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 956149004476 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 956149004477 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 956149004478 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 956149004479 active site 956149004480 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 956149004481 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 956149004482 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 956149004483 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 956149004484 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 956149004485 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 956149004486 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 956149004487 tRNA; other site 956149004488 putative tRNA binding site [nucleotide binding]; other site 956149004489 putative NADP binding site [chemical binding]; other site 956149004490 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 956149004491 peptide chain release factor 1; Validated; Region: prfA; PRK00591 956149004492 This domain is found in peptide chain release factors; Region: PCRF; smart00937 956149004493 RF-1 domain; Region: RF-1; pfam00472 956149004494 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 956149004495 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 956149004496 Invasion gene expression up-regulator, SirB; Region: SirB; cl01184 956149004497 hypothetical protein; Provisional; Region: PRK10941 956149004498 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 956149004499 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 956149004500 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 956149004501 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 956149004502 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 956149004503 cation transport regulator; Reviewed; Region: chaB; PRK09582 956149004504 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 956149004505 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 956149004506 putative active site pocket [active] 956149004507 dimerization interface [polypeptide binding]; other site 956149004508 putative catalytic residue [active] 956149004509 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 956149004510 Cache domain; Region: Cache_1; pfam02743 956149004511 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 956149004512 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 956149004513 dimerization interface [polypeptide binding]; other site 956149004514 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 956149004515 dimer interface [polypeptide binding]; other site 956149004516 putative CheW interface [polypeptide binding]; other site 956149004517 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 956149004518 Nitrate and nitrite sensing; Region: NIT; pfam08376 956149004519 ANTAR domain; Region: ANTAR; pfam03861 956149004520 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 956149004521 NMT1-like family; Region: NMT1_2; pfam13379 956149004522 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 956149004523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149004524 dimer interface [polypeptide binding]; other site 956149004525 conserved gate region; other site 956149004526 ABC-ATPase subunit interface; other site 956149004527 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 956149004528 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 956149004529 Cupin; Region: Cupin_6; pfam12852 956149004530 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 956149004531 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 956149004532 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 956149004533 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 956149004534 NAD(P) binding site [chemical binding]; other site 956149004535 active site 956149004536 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 956149004537 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 956149004538 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 956149004539 putative active site [active] 956149004540 putative substrate binding site [chemical binding]; other site 956149004541 putative cosubstrate binding site; other site 956149004542 catalytic site [active] 956149004543 SEC-C motif; Region: SEC-C; pfam02810 956149004544 hypothetical protein; Provisional; Region: PRK04233 956149004545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 956149004546 active site 956149004547 response regulator of RpoS; Provisional; Region: PRK10693 956149004548 phosphorylation site [posttranslational modification] 956149004549 intermolecular recognition site; other site 956149004550 dimerization interface [polypeptide binding]; other site 956149004551 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 956149004552 active site 956149004553 tetramer interface; other site 956149004554 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 956149004555 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 956149004556 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 956149004557 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 956149004558 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 956149004559 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 956149004560 putative NAD(P) binding site [chemical binding]; other site 956149004561 active site 956149004562 putative substrate binding site [chemical binding]; other site 956149004563 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 956149004564 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 956149004565 thymidine kinase; Provisional; Region: PRK04296 956149004566 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 956149004567 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 956149004568 putative catalytic cysteine [active] 956149004569 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 956149004570 putative active site [active] 956149004571 metal binding site [ion binding]; metal-binding site 956149004572 hypothetical protein; Provisional; Region: PRK11111 956149004573 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 956149004574 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 956149004575 peptide binding site [polypeptide binding]; other site 956149004576 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 956149004577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149004578 dimer interface [polypeptide binding]; other site 956149004579 conserved gate region; other site 956149004580 putative PBP binding loops; other site 956149004581 ABC-ATPase subunit interface; other site 956149004582 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 956149004583 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 956149004584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149004585 dimer interface [polypeptide binding]; other site 956149004586 conserved gate region; other site 956149004587 putative PBP binding loops; other site 956149004588 ABC-ATPase subunit interface; other site 956149004589 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 956149004590 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 956149004591 Walker A/P-loop; other site 956149004592 ATP binding site [chemical binding]; other site 956149004593 Q-loop/lid; other site 956149004594 ABC transporter signature motif; other site 956149004595 Walker B; other site 956149004596 D-loop; other site 956149004597 H-loop/switch region; other site 956149004598 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 956149004599 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 956149004600 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 956149004601 Walker A/P-loop; other site 956149004602 ATP binding site [chemical binding]; other site 956149004603 Q-loop/lid; other site 956149004604 ABC transporter signature motif; other site 956149004605 Walker B; other site 956149004606 D-loop; other site 956149004607 H-loop/switch region; other site 956149004608 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 956149004609 Ion transport protein; Region: Ion_trans; pfam00520 956149004610 Ion channel; Region: Ion_trans_2; pfam07885 956149004611 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 956149004612 Double zinc ribbon; Region: DZR; pfam12773 956149004613 dsDNA-mimic protein; Reviewed; Region: PRK05094 956149004614 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 956149004615 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 956149004616 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 956149004617 putative active site [active] 956149004618 catalytic site [active] 956149004619 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 956149004620 putative active site [active] 956149004621 catalytic site [active] 956149004622 YciI-like protein; Reviewed; Region: PRK11370 956149004623 transport protein TonB; Provisional; Region: PRK10819 956149004624 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 956149004625 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 956149004626 outer membrane receptor FepA; Provisional; Region: PRK13528 956149004627 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 956149004628 N-terminal plug; other site 956149004629 ligand-binding site [chemical binding]; other site 956149004630 intracellular septation protein A; Reviewed; Region: PRK00259 956149004631 hypothetical protein; Provisional; Region: PRK02868 956149004632 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 956149004633 outer membrane protein W; Provisional; Region: PRK10959 956149004634 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 956149004635 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 956149004636 substrate binding site [chemical binding]; other site 956149004637 active site 956149004638 catalytic residues [active] 956149004639 heterodimer interface [polypeptide binding]; other site 956149004640 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 956149004641 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 956149004642 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149004643 catalytic residue [active] 956149004644 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 956149004645 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 956149004646 active site 956149004647 ribulose/triose binding site [chemical binding]; other site 956149004648 phosphate binding site [ion binding]; other site 956149004649 substrate (anthranilate) binding pocket [chemical binding]; other site 956149004650 product (indole) binding pocket [chemical binding]; other site 956149004651 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 956149004652 active site 956149004653 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 956149004654 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 956149004655 glutamine binding [chemical binding]; other site 956149004656 catalytic triad [active] 956149004657 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 956149004658 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 956149004659 anthranilate synthase component I; Provisional; Region: PRK13564 956149004660 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 956149004661 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 956149004662 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 956149004663 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 956149004664 active site 956149004665 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 956149004666 hypothetical protein; Provisional; Region: PRK11630 956149004667 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 956149004668 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 956149004669 RNA binding surface [nucleotide binding]; other site 956149004670 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 956149004671 probable active site [active] 956149004672 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 956149004673 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 956149004674 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 956149004675 homodimer interface [polypeptide binding]; other site 956149004676 Walker A motif; other site 956149004677 ATP binding site [chemical binding]; other site 956149004678 hydroxycobalamin binding site [chemical binding]; other site 956149004679 Walker B motif; other site 956149004680 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 956149004681 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 956149004682 NADP binding site [chemical binding]; other site 956149004683 homodimer interface [polypeptide binding]; other site 956149004684 active site 956149004685 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 956149004686 putative inner membrane peptidase; Provisional; Region: PRK11778 956149004687 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 956149004688 tandem repeat interface [polypeptide binding]; other site 956149004689 oligomer interface [polypeptide binding]; other site 956149004690 active site residues [active] 956149004691 hypothetical protein; Provisional; Region: PRK11037 956149004692 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 956149004693 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 956149004694 active site 956149004695 interdomain interaction site; other site 956149004696 putative metal-binding site [ion binding]; other site 956149004697 nucleotide binding site [chemical binding]; other site 956149004698 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 956149004699 domain I; other site 956149004700 DNA binding groove [nucleotide binding] 956149004701 phosphate binding site [ion binding]; other site 956149004702 domain II; other site 956149004703 domain III; other site 956149004704 nucleotide binding site [chemical binding]; other site 956149004705 catalytic site [active] 956149004706 domain IV; other site 956149004707 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 956149004708 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 956149004709 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 956149004710 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 956149004711 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 956149004712 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149004713 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 956149004714 substrate binding site [chemical binding]; other site 956149004715 putative dimerization interface [polypeptide binding]; other site 956149004716 aconitate hydratase; Validated; Region: PRK09277 956149004717 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 956149004718 substrate binding site [chemical binding]; other site 956149004719 ligand binding site [chemical binding]; other site 956149004720 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 956149004721 substrate binding site [chemical binding]; other site 956149004722 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 956149004723 dimerization interface [polypeptide binding]; other site 956149004724 active site 956149004725 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 956149004726 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 956149004727 active site 956149004728 Predicted membrane protein [Function unknown]; Region: COG3771 956149004729 tetratricopeptide repeat protein; Provisional; Region: PRK11788 956149004730 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 956149004731 TPR motif; other site 956149004732 binding surface 956149004733 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 956149004734 binding surface 956149004735 TPR motif; other site 956149004736 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 956149004737 TPR motif; other site 956149004738 binding surface 956149004739 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 956149004740 active site 956149004741 dimer interface [polypeptide binding]; other site 956149004742 translation initiation factor Sui1; Validated; Region: PRK06824 956149004743 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 956149004744 putative rRNA binding site [nucleotide binding]; other site 956149004745 lipoprotein; Provisional; Region: PRK10540 956149004746 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 956149004747 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 956149004748 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 956149004749 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 956149004750 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 956149004751 dimer interface [polypeptide binding]; other site 956149004752 active site 956149004753 glycine loop; other site 956149004754 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 956149004755 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 956149004756 FeS/SAM binding site; other site 956149004757 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 956149004758 active site 956149004759 intersubunit interactions; other site 956149004760 catalytic residue [active] 956149004761 hypothetical protein; Provisional; Region: PRK13658 956149004762 enoyl-CoA hydratase; Validated; Region: PRK08788 956149004763 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 956149004764 substrate binding site [chemical binding]; other site 956149004765 oxyanion hole (OAH) forming residues; other site 956149004766 trimer interface [polypeptide binding]; other site 956149004767 RNase II stability modulator; Provisional; Region: PRK10060 956149004768 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 956149004769 putative active site [active] 956149004770 heme pocket [chemical binding]; other site 956149004771 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 956149004772 metal binding site [ion binding]; metal-binding site 956149004773 active site 956149004774 I-site; other site 956149004775 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 956149004776 exoribonuclease II; Provisional; Region: PRK05054 956149004777 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 956149004778 RNB domain; Region: RNB; pfam00773 956149004779 S1 RNA binding domain; Region: S1; pfam00575 956149004780 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 956149004781 Uncharacterized conserved protein [Function unknown]; Region: COG2128 956149004782 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 956149004783 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 956149004784 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 956149004785 NAD binding site [chemical binding]; other site 956149004786 homotetramer interface [polypeptide binding]; other site 956149004787 homodimer interface [polypeptide binding]; other site 956149004788 substrate binding site [chemical binding]; other site 956149004789 active site 956149004790 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 956149004791 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 956149004792 Walker A/P-loop; other site 956149004793 ATP binding site [chemical binding]; other site 956149004794 Q-loop/lid; other site 956149004795 ABC transporter signature motif; other site 956149004796 Walker B; other site 956149004797 D-loop; other site 956149004798 H-loop/switch region; other site 956149004799 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 956149004800 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 956149004801 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 956149004802 Walker A/P-loop; other site 956149004803 ATP binding site [chemical binding]; other site 956149004804 Q-loop/lid; other site 956149004805 ABC transporter signature motif; other site 956149004806 Walker B; other site 956149004807 D-loop; other site 956149004808 H-loop/switch region; other site 956149004809 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 956149004810 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 956149004811 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 956149004812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149004813 dimer interface [polypeptide binding]; other site 956149004814 conserved gate region; other site 956149004815 putative PBP binding loops; other site 956149004816 ABC-ATPase subunit interface; other site 956149004817 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 956149004818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149004819 dimer interface [polypeptide binding]; other site 956149004820 conserved gate region; other site 956149004821 putative PBP binding loops; other site 956149004822 ABC-ATPase subunit interface; other site 956149004823 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 956149004824 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 956149004825 peptide binding site [polypeptide binding]; other site 956149004826 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 956149004827 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 956149004828 Walker A motif; other site 956149004829 ATP binding site [chemical binding]; other site 956149004830 Walker B motif; other site 956149004831 arginine finger; other site 956149004832 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 956149004833 phage shock protein PspA; Provisional; Region: PRK10698 956149004834 phage shock protein B; Provisional; Region: pspB; PRK09458 956149004835 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 956149004836 phage shock protein C; Region: phageshock_pspC; TIGR02978 956149004837 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 956149004838 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 956149004839 sucrose phosphorylase; Provisional; Region: PRK13840 956149004840 active site 956149004841 homodimer interface [polypeptide binding]; other site 956149004842 catalytic site [active] 956149004843 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 956149004844 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 956149004845 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 956149004846 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 956149004847 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149004848 dimer interface [polypeptide binding]; other site 956149004849 conserved gate region; other site 956149004850 putative PBP binding loops; other site 956149004851 ABC-ATPase subunit interface; other site 956149004852 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 956149004853 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149004854 dimer interface [polypeptide binding]; other site 956149004855 conserved gate region; other site 956149004856 putative PBP binding loops; other site 956149004857 ABC-ATPase subunit interface; other site 956149004858 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 956149004859 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 956149004860 putative NAD(P) binding site [chemical binding]; other site 956149004861 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 956149004862 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 956149004863 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 956149004864 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 956149004865 Int/Topo IB signature motif; other site 956149004866 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 956149004867 AAA domain; Region: AAA_24; pfam13479 956149004868 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 956149004869 FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354 956149004870 transcriptional repressor DicA; Reviewed; Region: PRK09706 956149004871 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 956149004872 non-specific DNA binding site [nucleotide binding]; other site 956149004873 salt bridge; other site 956149004874 sequence-specific DNA binding site [nucleotide binding]; other site 956149004875 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 956149004876 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 956149004877 Helix-turn-helix domain; Region: HTH_36; pfam13730 956149004878 primosomal protein DnaI; Provisional; Region: PRK02854 956149004879 ParB-like nuclease domain; Region: ParBc; pfam02195 956149004880 Predicted ATPases [General function prediction only]; Region: COG1106 956149004881 hypothetical protein; Provisional; Region: PRK09741 956149004882 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 956149004883 Endodeoxyribonuclease RusA; Region: RusA; cl01885 956149004884 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 956149004885 Lysis protein S; Region: Lysis_S; pfam04971 956149004886 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 956149004887 catalytic residues [active] 956149004888 Sigma-S stabilisation anti-adaptor protein; Region: Anti-adapt_IraP; cl11681 956149004889 Sigma-S stabilisation anti-adaptor protein; Region: Anti-adapt_IraP; cl11681 956149004890 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 956149004891 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 956149004892 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 956149004893 active site 956149004894 Phage terminase, small subunit; Region: Terminase_4; pfam05119 956149004895 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 956149004896 Phage portal protein; Region: Phage_portal; pfam04860 956149004897 Phage-related protein [Function unknown]; Region: COG4695 956149004898 Phage head maturation protease [General function prediction only]; Region: COG3740 956149004899 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 956149004900 Phage capsid family; Region: Phage_capsid; pfam05065 956149004901 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 956149004902 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 956149004903 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 956149004904 oligomerization interface [polypeptide binding]; other site 956149004905 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 956149004906 Protein of unknown function (DUF2635); Region: DUF2635; pfam10948 956149004907 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 956149004908 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 956149004909 Phage tail tube protein; Region: Tail_tube; pfam10618 956149004910 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 956149004911 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 956149004912 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 956149004913 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 956149004914 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 956149004915 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 956149004916 Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; cl15410 956149004917 Phage protein GP46; Region: GP46; pfam07409 956149004918 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 956149004919 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 956149004920 Septum formation initiator; Region: DivIC; cl17659 956149004921 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 956149004922 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 956149004923 dimerization interface [polypeptide binding]; other site 956149004924 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 956149004925 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 956149004926 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 956149004927 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 956149004928 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 956149004929 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 956149004930 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 956149004931 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 956149004932 beta-phosphoglucomutase; Region: bPGM; TIGR01990 956149004933 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 956149004934 motif II; other site 956149004935 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 956149004936 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 956149004937 Walker A/P-loop; other site 956149004938 ATP binding site [chemical binding]; other site 956149004939 Q-loop/lid; other site 956149004940 ABC transporter signature motif; other site 956149004941 Walker B; other site 956149004942 D-loop; other site 956149004943 H-loop/switch region; other site 956149004944 TOBE domain; Region: TOBE_2; pfam08402 956149004945 Transcriptional regulators [Transcription]; Region: PurR; COG1609 956149004946 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 956149004947 DNA binding site [nucleotide binding] 956149004948 domain linker motif; other site 956149004949 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 956149004950 Predicted ATPase [General function prediction only]; Region: COG3106 956149004951 hypothetical protein; Provisional; Region: PRK05415 956149004952 Domain of unknown function (DUF697); Region: DUF697; cl12064 956149004953 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 956149004954 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 956149004955 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 956149004956 putative active site [active] 956149004957 heme pocket [chemical binding]; other site 956149004958 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 956149004959 Walker A motif; other site 956149004960 ATP binding site [chemical binding]; other site 956149004961 Walker B motif; other site 956149004962 arginine finger; other site 956149004963 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 956149004964 dimer interface [polypeptide binding]; other site 956149004965 catalytic triad [active] 956149004966 peroxidatic and resolving cysteines [active] 956149004967 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 956149004968 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 956149004969 active site 956149004970 murein peptide amidase A; Provisional; Region: PRK10602 956149004971 active site 956149004972 Zn binding site [ion binding]; other site 956149004973 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 956149004974 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 956149004975 peptide binding site [polypeptide binding]; other site 956149004976 anti-adapter protein IraM; Provisional; Region: PRK09919 956149004977 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 956149004978 General stress protein [General function prediction only]; Region: GsiB; COG3729 956149004979 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 956149004980 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 956149004981 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 956149004982 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 956149004983 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 956149004984 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 956149004985 Cl binding site [ion binding]; other site 956149004986 oligomer interface [polypeptide binding]; other site 956149004987 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 956149004988 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 956149004989 Ligand Binding Site [chemical binding]; other site 956149004990 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 956149004991 putative catalytic site [active] 956149004992 putative metal binding site [ion binding]; other site 956149004993 putative phosphate binding site [ion binding]; other site 956149004994 short chain dehydrogenase; Provisional; Region: PRK06701 956149004995 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 956149004996 NAD binding site [chemical binding]; other site 956149004997 metal binding site [ion binding]; metal-binding site 956149004998 active site 956149004999 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 956149005000 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 956149005001 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 956149005002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 956149005003 Walker A motif; other site 956149005004 ATP binding site [chemical binding]; other site 956149005005 Walker B motif; other site 956149005006 arginine finger; other site 956149005007 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 956149005008 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 956149005009 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 956149005010 NAD(P) binding site [chemical binding]; other site 956149005011 catalytic residues [active] 956149005012 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 956149005013 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 956149005014 NAD binding site [chemical binding]; other site 956149005015 substrate binding site [chemical binding]; other site 956149005016 catalytic Zn binding site [ion binding]; other site 956149005017 tetramer interface [polypeptide binding]; other site 956149005018 structural Zn binding site [ion binding]; other site 956149005019 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 956149005020 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 956149005021 dimer interface [polypeptide binding]; other site 956149005022 PYR/PP interface [polypeptide binding]; other site 956149005023 TPP binding site [chemical binding]; other site 956149005024 substrate binding site [chemical binding]; other site 956149005025 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 956149005026 Domain of unknown function; Region: EKR; smart00890 956149005027 4Fe-4S binding domain; Region: Fer4_6; pfam12837 956149005028 4Fe-4S binding domain; Region: Fer4; pfam00037 956149005029 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 956149005030 TPP-binding site [chemical binding]; other site 956149005031 dimer interface [polypeptide binding]; other site 956149005032 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 956149005033 Domain of unknown function (DUF333); Region: DUF333; pfam03891 956149005034 META domain; Region: META; cl01245 956149005035 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 956149005036 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 956149005037 putative ligand binding site [chemical binding]; other site 956149005038 putative NAD binding site [chemical binding]; other site 956149005039 catalytic site [active] 956149005040 hypothetical protein; Provisional; Region: PRK10695 956149005041 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 956149005042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 956149005043 azoreductase; Reviewed; Region: PRK00170 956149005044 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 956149005045 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 956149005046 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 956149005047 ATP binding site [chemical binding]; other site 956149005048 putative Mg++ binding site [ion binding]; other site 956149005049 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 956149005050 nucleotide binding region [chemical binding]; other site 956149005051 ATP-binding site [chemical binding]; other site 956149005052 Helicase associated domain (HA2); Region: HA2; pfam04408 956149005053 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 956149005054 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 956149005055 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 956149005056 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 956149005057 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 956149005058 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 956149005059 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 956149005060 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 956149005061 HlyD family secretion protein; Region: HlyD_3; pfam13437 956149005062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149005063 putative substrate translocation pore; other site 956149005064 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 956149005065 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 956149005066 MarR family; Region: MarR_2; pfam12802 956149005067 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 956149005068 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 956149005069 Coenzyme A binding pocket [chemical binding]; other site 956149005070 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 956149005071 FosA, a Fosfomycin resistance protein, catalyzes the addition of glutathione to the antibiotic fosfomycin, making it inactive; Region: FosA; cd07244 956149005072 dimer interface [polypeptide binding]; other site 956149005073 Mn binding site [ion binding]; other site 956149005074 K binding site [ion binding]; other site 956149005075 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 956149005076 Uncharacterized conserved protein [Function unknown]; Region: COG1434 956149005077 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 956149005078 putative active site [active] 956149005079 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 956149005080 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 956149005081 NAD binding site [chemical binding]; other site 956149005082 catalytic residues [active] 956149005083 substrate binding site [chemical binding]; other site 956149005084 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 956149005085 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 956149005086 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 956149005087 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149005088 metabolite-proton symporter; Region: 2A0106; TIGR00883 956149005089 putative substrate translocation pore; other site 956149005090 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 956149005091 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 956149005092 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 956149005093 putative metal binding site [ion binding]; other site 956149005094 putative homodimer interface [polypeptide binding]; other site 956149005095 putative homotetramer interface [polypeptide binding]; other site 956149005096 putative homodimer-homodimer interface [polypeptide binding]; other site 956149005097 putative allosteric switch controlling residues; other site 956149005098 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 956149005099 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 956149005100 substrate binding site [chemical binding]; other site 956149005101 catalytic Zn binding site [ion binding]; other site 956149005102 NAD binding site [chemical binding]; other site 956149005103 structural Zn binding site [ion binding]; other site 956149005104 dimer interface [polypeptide binding]; other site 956149005105 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 956149005106 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 956149005107 dimer interface [polypeptide binding]; other site 956149005108 ligand binding site [chemical binding]; other site 956149005109 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 956149005110 dimerization interface [polypeptide binding]; other site 956149005111 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 956149005112 dimer interface [polypeptide binding]; other site 956149005113 putative CheW interface [polypeptide binding]; other site 956149005114 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 956149005115 dimerization interface [polypeptide binding]; other site 956149005116 metal binding site [ion binding]; metal-binding site 956149005117 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 956149005118 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 956149005119 FMN binding site [chemical binding]; other site 956149005120 active site 956149005121 substrate binding site [chemical binding]; other site 956149005122 catalytic residue [active] 956149005123 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 956149005124 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149005125 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 956149005126 dimerization interface [polypeptide binding]; other site 956149005127 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 956149005128 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 956149005129 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 956149005130 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 956149005131 substrate binding pocket [chemical binding]; other site 956149005132 catalytic triad [active] 956149005133 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 956149005134 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 956149005135 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 956149005136 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 956149005137 Coenzyme A binding pocket [chemical binding]; other site 956149005138 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 956149005139 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 956149005140 putative trimer interface [polypeptide binding]; other site 956149005141 putative CoA binding site [chemical binding]; other site 956149005142 tellurite resistance protein TehB; Provisional; Region: PRK11207 956149005143 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 956149005144 S-adenosylmethionine binding site [chemical binding]; other site 956149005145 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 956149005146 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 956149005147 benzoate transporter; Region: benE; TIGR00843 956149005148 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 956149005149 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 956149005150 non-specific DNA binding site [nucleotide binding]; other site 956149005151 salt bridge; other site 956149005152 sequence-specific DNA binding site [nucleotide binding]; other site 956149005153 Cupin domain; Region: Cupin_2; pfam07883 956149005154 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 956149005155 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 956149005156 Peptidase family U32; Region: Peptidase_U32; pfam01136 956149005157 Collagenase; Region: DUF3656; pfam12392 956149005158 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 956149005159 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 956149005160 Catalytic site [active] 956149005161 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 956149005162 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 956149005163 active site 956149005164 DNA binding site [nucleotide binding] 956149005165 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 956149005166 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 956149005167 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 956149005168 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 956149005169 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 956149005170 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 956149005171 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 956149005172 active site 956149005173 Zn binding site [ion binding]; other site 956149005174 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 956149005175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149005176 putative substrate translocation pore; other site 956149005177 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 956149005178 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149005179 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 956149005180 dimerization interface [polypeptide binding]; other site 956149005181 substrate binding pocket [chemical binding]; other site 956149005182 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 956149005183 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 956149005184 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 956149005185 putative dithiobiotin synthetase; Provisional; Region: PRK12374 956149005186 AAA domain; Region: AAA_26; pfam13500 956149005187 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 956149005188 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 956149005189 Walker A/P-loop; other site 956149005190 ATP binding site [chemical binding]; other site 956149005191 Q-loop/lid; other site 956149005192 ABC transporter signature motif; other site 956149005193 Walker B; other site 956149005194 D-loop; other site 956149005195 H-loop/switch region; other site 956149005196 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 956149005197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149005198 dimer interface [polypeptide binding]; other site 956149005199 conserved gate region; other site 956149005200 ABC-ATPase subunit interface; other site 956149005201 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 956149005202 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 956149005203 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149005204 putative PBP binding loops; other site 956149005205 dimer interface [polypeptide binding]; other site 956149005206 ABC-ATPase subunit interface; other site 956149005207 GlpM protein; Region: GlpM; pfam06942 956149005208 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 956149005209 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 956149005210 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 956149005211 4Fe-4S binding domain; Region: Fer4; pfam00037 956149005212 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 956149005213 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 956149005214 putative [Fe4-S4] binding site [ion binding]; other site 956149005215 putative molybdopterin cofactor binding site [chemical binding]; other site 956149005216 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 956149005217 putative molybdopterin cofactor binding site; other site 956149005218 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 956149005219 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 956149005220 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 956149005221 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 956149005222 Coenzyme A binding pocket [chemical binding]; other site 956149005223 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 956149005224 hypothetical protein; Provisional; Region: PRK13659 956149005225 hypothetical protein; Provisional; Region: PRK02237 956149005226 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 956149005227 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 956149005228 metal binding site [ion binding]; metal-binding site 956149005229 substrate binding pocket [chemical binding]; other site 956149005230 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149005231 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 956149005232 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 956149005233 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 956149005234 YdfZ protein; Region: YdfZ; pfam14001 956149005235 Transcriptional regulators [Transcription]; Region: GntR; COG1802 956149005236 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 956149005237 DNA-binding site [nucleotide binding]; DNA binding site 956149005238 FCD domain; Region: FCD; pfam07729 956149005239 malonic semialdehyde reductase; Provisional; Region: PRK10538 956149005240 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 956149005241 putative NAD(P) binding site [chemical binding]; other site 956149005242 homodimer interface [polypeptide binding]; other site 956149005243 homotetramer interface [polypeptide binding]; other site 956149005244 active site 956149005245 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 956149005246 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 956149005247 active site 956149005248 Zn binding site [ion binding]; other site 956149005249 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 956149005250 transcriptional regulator MirA; Provisional; Region: PRK15043 956149005251 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 956149005252 Protein of unknown function (DUF1264); Region: DUF1264; pfam06884 956149005253 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 956149005254 substrate binding site [chemical binding]; other site 956149005255 THF binding site; other site 956149005256 zinc-binding site [ion binding]; other site 956149005257 allophanate hydrolase; Provisional; Region: PRK08186 956149005258 Amidase; Region: Amidase; pfam01425 956149005259 urea carboxylase; Region: urea_carbox; TIGR02712 956149005260 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 956149005261 ATP-grasp domain; Region: ATP-grasp_4; cl17255 956149005262 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 956149005263 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 956149005264 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 956149005265 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 956149005266 carboxyltransferase (CT) interaction site; other site 956149005267 biotinylation site [posttranslational modification]; other site 956149005268 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 956149005269 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 956149005270 DNA-binding site [nucleotide binding]; DNA binding site 956149005271 FCD domain; Region: FCD; pfam07729 956149005272 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 956149005273 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 956149005274 putative ligand binding site [chemical binding]; other site 956149005275 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 956149005276 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 956149005277 TM-ABC transporter signature motif; other site 956149005278 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 956149005279 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 956149005280 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 956149005281 TM-ABC transporter signature motif; other site 956149005282 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 956149005283 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 956149005284 Walker A/P-loop; other site 956149005285 ATP binding site [chemical binding]; other site 956149005286 Q-loop/lid; other site 956149005287 ABC transporter signature motif; other site 956149005288 Walker B; other site 956149005289 D-loop; other site 956149005290 H-loop/switch region; other site 956149005291 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 956149005292 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 956149005293 Walker A/P-loop; other site 956149005294 ATP binding site [chemical binding]; other site 956149005295 Q-loop/lid; other site 956149005296 ABC transporter signature motif; other site 956149005297 Walker B; other site 956149005298 D-loop; other site 956149005299 H-loop/switch region; other site 956149005300 putative transporter; Provisional; Region: PRK10054 956149005301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149005302 putative substrate translocation pore; other site 956149005303 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 956149005304 EamA-like transporter family; Region: EamA; pfam00892 956149005305 MarB protein; Region: MarB; pfam13999 956149005306 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 956149005307 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 956149005308 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 956149005309 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 956149005310 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 956149005311 putative arabinose transporter; Provisional; Region: PRK03545 956149005312 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149005313 putative substrate translocation pore; other site 956149005314 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 956149005315 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 956149005316 tetramer (dimer of dimers) interface [polypeptide binding]; other site 956149005317 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 956149005318 NAD binding site [chemical binding]; other site 956149005319 dimer interface [polypeptide binding]; other site 956149005320 substrate binding site [chemical binding]; other site 956149005321 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 956149005322 Coenzyme A binding pocket [chemical binding]; other site 956149005323 Transcriptional regulator [Transcription]; Region: LysR; COG0583 956149005324 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149005325 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 956149005326 putative dimerization interface [polypeptide binding]; other site 956149005327 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 956149005328 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 956149005329 NAD(P) binding site [chemical binding]; other site 956149005330 catalytic residues [active] 956149005331 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 956149005332 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 956149005333 dimer interface [polypeptide binding]; other site 956149005334 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 956149005335 dimerization interface [polypeptide binding]; other site 956149005336 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 956149005337 dimer interface [polypeptide binding]; other site 956149005338 putative CheW interface [polypeptide binding]; other site 956149005339 glutaminase; Provisional; Region: PRK00971 956149005340 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 956149005341 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 956149005342 MASE1; Region: MASE1; cl17823 956149005343 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 956149005344 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 956149005345 metal binding site [ion binding]; metal-binding site 956149005346 active site 956149005347 I-site; other site 956149005348 MASE2 domain; Region: MASE2; pfam05230 956149005349 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 956149005350 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 956149005351 metal binding site [ion binding]; metal-binding site 956149005352 active site 956149005353 I-site; other site 956149005354 GAF domain; Region: GAF; pfam01590 956149005355 GAF domain; Region: GAF_2; pfam13185 956149005356 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 956149005357 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 956149005358 metal binding site [ion binding]; metal-binding site 956149005359 active site 956149005360 I-site; other site 956149005361 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 956149005362 Coenzyme A binding pocket [chemical binding]; other site 956149005363 altronate oxidoreductase; Provisional; Region: PRK03643 956149005364 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 956149005365 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 956149005366 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 956149005367 active site 956149005368 catalytic triad [active] 956149005369 oxyanion hole [active] 956149005370 Autotransporter beta-domain; Region: Autotransporter; cl17461 956149005371 trehalase; Provisional; Region: treF; PRK13270 956149005372 Trehalase; Region: Trehalase; cl17346 956149005373 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 956149005374 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 956149005375 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 956149005376 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 956149005377 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 956149005378 putative active site [active] 956149005379 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 956149005380 heme pocket [chemical binding]; other site 956149005381 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 956149005382 dimer interface [polypeptide binding]; other site 956149005383 phosphorylation site [posttranslational modification] 956149005384 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 956149005385 ATP binding site [chemical binding]; other site 956149005386 Mg2+ binding site [ion binding]; other site 956149005387 G-X-G motif; other site 956149005388 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 956149005389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 956149005390 active site 956149005391 phosphorylation site [posttranslational modification] 956149005392 intermolecular recognition site; other site 956149005393 dimerization interface [polypeptide binding]; other site 956149005394 Response regulator receiver domain; Region: Response_reg; pfam00072 956149005395 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 956149005396 active site 956149005397 phosphorylation site [posttranslational modification] 956149005398 intermolecular recognition site; other site 956149005399 dimerization interface [polypeptide binding]; other site 956149005400 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 956149005401 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 956149005402 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 956149005403 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 956149005404 DXD motif; other site 956149005405 OpgC protein; Region: OpgC_C; cl17858 956149005406 Response regulator receiver domain; Region: Response_reg; pfam00072 956149005407 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 956149005408 active site 956149005409 phosphorylation site [posttranslational modification] 956149005410 intermolecular recognition site; other site 956149005411 dimerization interface [polypeptide binding]; other site 956149005412 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 956149005413 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 956149005414 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 956149005415 anti sigma factor interaction site; other site 956149005416 regulatory phosphorylation site [posttranslational modification]; other site 956149005417 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 956149005418 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 956149005419 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 956149005420 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 956149005421 non-specific DNA binding site [nucleotide binding]; other site 956149005422 salt bridge; other site 956149005423 sequence-specific DNA binding site [nucleotide binding]; other site 956149005424 Cupin domain; Region: Cupin_2; pfam07883 956149005425 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 956149005426 B3/4 domain; Region: B3_4; pfam03483 956149005427 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 956149005428 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 956149005429 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 956149005430 Serine hydrolase; Region: Ser_hydrolase; cl17834 956149005431 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 956149005432 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 956149005433 DNA binding residues [nucleotide binding] 956149005434 putative dimer interface [polypeptide binding]; other site 956149005435 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 956149005436 NlpC/P60 family; Region: NLPC_P60; pfam00877 956149005437 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 956149005438 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 956149005439 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 956149005440 EAL domain; Region: EAL; pfam00563 956149005441 UV-endonuclease UvdE; Region: UvdE; cl10036 956149005442 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 956149005443 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 956149005444 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 956149005445 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 956149005446 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 956149005447 NAD(P) binding site [chemical binding]; other site 956149005448 active site 956149005449 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 956149005450 TfoX N-terminal domain; Region: TfoX_N; pfam04993 956149005451 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 956149005452 classical (c) SDRs; Region: SDR_c; cd05233 956149005453 NAD(P) binding site [chemical binding]; other site 956149005454 active site 956149005455 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 956149005456 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 956149005457 putative NAD(P) binding site [chemical binding]; other site 956149005458 putative substrate binding site [chemical binding]; other site 956149005459 catalytic Zn binding site [ion binding]; other site 956149005460 structural Zn binding site [ion binding]; other site 956149005461 dimer interface [polypeptide binding]; other site 956149005462 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 956149005463 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 956149005464 Cupin; Region: Cupin_6; pfam12852 956149005465 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 956149005466 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 956149005467 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 956149005468 N-acetyltransferase; Region: Acetyltransf_2; cl00949 956149005469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 956149005470 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 956149005471 dimanganese center [ion binding]; other site 956149005472 4-oxalocrotonate tautomerase; Provisional; Region: PRK01271 956149005473 active site 1 [active] 956149005474 dimer interface [polypeptide binding]; other site 956149005475 hexamer interface [polypeptide binding]; other site 956149005476 active site 2 [active] 956149005477 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 956149005478 dimer interface [polypeptide binding]; other site 956149005479 FMN binding site [chemical binding]; other site 956149005480 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 956149005481 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 956149005482 L-asparagine permease; Provisional; Region: PRK15049 956149005483 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 956149005484 NMT1-like family; Region: NMT1_2; pfam13379 956149005485 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 956149005486 substrate binding pocket [chemical binding]; other site 956149005487 membrane-bound complex binding site; other site 956149005488 hinge residues; other site 956149005489 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 956149005490 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 956149005491 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 956149005492 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 956149005493 Walker A/P-loop; other site 956149005494 ATP binding site [chemical binding]; other site 956149005495 Q-loop/lid; other site 956149005496 ABC transporter signature motif; other site 956149005497 Walker B; other site 956149005498 D-loop; other site 956149005499 H-loop/switch region; other site 956149005500 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 956149005501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149005502 dimer interface [polypeptide binding]; other site 956149005503 conserved gate region; other site 956149005504 putative PBP binding loops; other site 956149005505 ABC-ATPase subunit interface; other site 956149005506 PQQ-like domain; Region: PQQ_2; pfam13360 956149005507 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 956149005508 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 956149005509 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 956149005510 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 956149005511 ligand-binding site [chemical binding]; other site 956149005512 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 956149005513 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 956149005514 non-specific DNA binding site [nucleotide binding]; other site 956149005515 salt bridge; other site 956149005516 sequence-specific DNA binding site [nucleotide binding]; other site 956149005517 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 956149005518 trehalose synthase; Region: treS_nterm; TIGR02456 956149005519 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 956149005520 active site 956149005521 catalytic site [active] 956149005522 short chain dehydrogenase; Provisional; Region: PRK07109 956149005523 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 956149005524 putative NAD(P) binding site [chemical binding]; other site 956149005525 active site 956149005526 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 956149005527 HAMP domain; Region: HAMP; pfam00672 956149005528 dimerization interface [polypeptide binding]; other site 956149005529 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 956149005530 dimer interface [polypeptide binding]; other site 956149005531 putative CheW interface [polypeptide binding]; other site 956149005532 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 956149005533 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 956149005534 DNA-binding site [nucleotide binding]; DNA binding site 956149005535 FCD domain; Region: FCD; pfam07729 956149005536 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 956149005537 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 956149005538 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 956149005539 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149005540 dimer interface [polypeptide binding]; other site 956149005541 conserved gate region; other site 956149005542 putative PBP binding loops; other site 956149005543 ABC-ATPase subunit interface; other site 956149005544 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 956149005545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149005546 dimer interface [polypeptide binding]; other site 956149005547 conserved gate region; other site 956149005548 putative PBP binding loops; other site 956149005549 ABC-ATPase subunit interface; other site 956149005550 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 956149005551 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 956149005552 metal binding site [ion binding]; metal-binding site 956149005553 potential frameshift: common BLAST hit: gi|389841054|ref|YP_006343138.1| ornithine cyclodeaminase 956149005554 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 956149005555 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 956149005556 Walker A/P-loop; other site 956149005557 ATP binding site [chemical binding]; other site 956149005558 Q-loop/lid; other site 956149005559 ABC transporter signature motif; other site 956149005560 Walker B; other site 956149005561 D-loop; other site 956149005562 H-loop/switch region; other site 956149005563 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 956149005564 Walker A/P-loop; other site 956149005565 ATP binding site [chemical binding]; other site 956149005566 Q-loop/lid; other site 956149005567 ABC transporter signature motif; other site 956149005568 Walker B; other site 956149005569 D-loop; other site 956149005570 H-loop/switch region; other site 956149005571 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 956149005572 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 956149005573 Prostaglandin dehydrogenases; Region: PGDH; cd05288 956149005574 NAD(P) binding site [chemical binding]; other site 956149005575 substrate binding site [chemical binding]; other site 956149005576 dimer interface [polypeptide binding]; other site 956149005577 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 956149005578 non-specific DNA binding site [nucleotide binding]; other site 956149005579 salt bridge; other site 956149005580 sequence-specific DNA binding site [nucleotide binding]; other site 956149005581 Cupin domain; Region: Cupin_2; pfam07883 956149005582 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 956149005583 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 956149005584 Coenzyme A binding pocket [chemical binding]; other site 956149005585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 956149005586 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 956149005587 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 956149005588 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 956149005589 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 956149005590 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 956149005591 peptide binding site [polypeptide binding]; other site 956149005592 potential frameshift: common BLAST hit: gi|389841065|ref|YP_006343149.1| virulence protein SrfB 956149005593 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458 956149005594 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 956149005595 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 956149005596 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 956149005597 Metal-binding active site; metal-binding site 956149005598 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 956149005599 Tar ligand binding domain homologue; Region: TarH; pfam02203 956149005600 dimer interface [polypeptide binding]; other site 956149005601 ligand binding site [chemical binding]; other site 956149005602 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 956149005603 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 956149005604 dimerization interface [polypeptide binding]; other site 956149005605 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 956149005606 dimer interface [polypeptide binding]; other site 956149005607 putative CheW interface [polypeptide binding]; other site 956149005608 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 956149005609 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 956149005610 4Fe-4S binding domain; Region: Fer4; pfam00037 956149005611 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 956149005612 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 956149005613 4Fe-4S binding domain; Region: Fer4; pfam00037 956149005614 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 956149005615 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 956149005616 putative [Fe4-S4] binding site [ion binding]; other site 956149005617 putative molybdopterin cofactor binding site [chemical binding]; other site 956149005618 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 956149005619 putative molybdopterin cofactor binding site; other site 956149005620 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 956149005621 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 956149005622 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 956149005623 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 956149005624 putative acetyltransferase; Provisional; Region: PRK03624 956149005625 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 956149005626 Coenzyme A binding pocket [chemical binding]; other site 956149005627 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 956149005628 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 956149005629 tetrameric interface [polypeptide binding]; other site 956149005630 NAD binding site [chemical binding]; other site 956149005631 catalytic residues [active] 956149005632 substrate binding site [chemical binding]; other site 956149005633 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 956149005634 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149005635 putative PBP binding loops; other site 956149005636 dimer interface [polypeptide binding]; other site 956149005637 ABC-ATPase subunit interface; other site 956149005638 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149005639 dimer interface [polypeptide binding]; other site 956149005640 conserved gate region; other site 956149005641 putative PBP binding loops; other site 956149005642 ABC-ATPase subunit interface; other site 956149005643 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 956149005644 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 956149005645 Walker A/P-loop; other site 956149005646 ATP binding site [chemical binding]; other site 956149005647 Q-loop/lid; other site 956149005648 ABC transporter signature motif; other site 956149005649 Walker B; other site 956149005650 D-loop; other site 956149005651 H-loop/switch region; other site 956149005652 TOBE domain; Region: TOBE_2; pfam08402 956149005653 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 956149005654 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 956149005655 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 956149005656 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 956149005657 DNA-binding site [nucleotide binding]; DNA binding site 956149005658 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 956149005659 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149005660 homodimer interface [polypeptide binding]; other site 956149005661 catalytic residue [active] 956149005662 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 956149005663 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 956149005664 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 956149005665 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 956149005666 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 956149005667 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 956149005668 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 956149005669 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 956149005670 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 956149005671 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 956149005672 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 956149005673 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 956149005674 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 956149005675 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 956149005676 potential frameshift: common BLAST hit: gi|389841098|ref|YP_006343182.1| ABC transporter permease 956149005677 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 956149005678 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149005679 putative PBP binding loops; other site 956149005680 dimer interface [polypeptide binding]; other site 956149005681 ABC-ATPase subunit interface; other site 956149005682 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 956149005683 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 956149005684 Walker A/P-loop; other site 956149005685 ATP binding site [chemical binding]; other site 956149005686 Q-loop/lid; other site 956149005687 ABC transporter signature motif; other site 956149005688 Walker B; other site 956149005689 D-loop; other site 956149005690 H-loop/switch region; other site 956149005691 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 956149005692 Walker A/P-loop; other site 956149005693 ATP binding site [chemical binding]; other site 956149005694 Q-loop/lid; other site 956149005695 ABC transporter signature motif; other site 956149005696 Walker B; other site 956149005697 D-loop; other site 956149005698 H-loop/switch region; other site 956149005699 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 956149005700 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 956149005701 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 956149005702 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 956149005703 alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030 956149005704 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 956149005705 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 956149005706 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 956149005707 active site 956149005708 motif I; other site 956149005709 motif II; other site 956149005710 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 956149005711 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 956149005712 Smr domain; Region: Smr; pfam01713 956149005713 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 956149005714 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 956149005715 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 956149005716 DNA binding site [nucleotide binding] 956149005717 active site 956149005718 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 956149005719 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 956149005720 ligand binding site [chemical binding]; other site 956149005721 flexible hinge region; other site 956149005722 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 956149005723 putative switch regulator; other site 956149005724 non-specific DNA interactions [nucleotide binding]; other site 956149005725 DNA binding site [nucleotide binding] 956149005726 sequence specific DNA binding site [nucleotide binding]; other site 956149005727 putative cAMP binding site [chemical binding]; other site 956149005728 universal stress protein UspE; Provisional; Region: PRK11175 956149005729 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 956149005730 Ligand Binding Site [chemical binding]; other site 956149005731 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 956149005732 Ligand Binding Site [chemical binding]; other site 956149005733 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 956149005734 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 956149005735 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 956149005736 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 956149005737 ligand binding site [chemical binding]; other site 956149005738 homodimer interface [polypeptide binding]; other site 956149005739 NAD(P) binding site [chemical binding]; other site 956149005740 trimer interface B [polypeptide binding]; other site 956149005741 trimer interface A [polypeptide binding]; other site 956149005742 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 956149005743 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 956149005744 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 956149005745 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 956149005746 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 956149005747 dihydromonapterin reductase; Provisional; Region: PRK06483 956149005748 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 956149005749 NAD(P) binding site [chemical binding]; other site 956149005750 active site 956149005751 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 956149005752 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 956149005753 active site 956149005754 phosphorylation site [posttranslational modification] 956149005755 intermolecular recognition site; other site 956149005756 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 956149005757 DNA binding site [nucleotide binding] 956149005758 short chain dehydrogenase; Provisional; Region: PRK06500 956149005759 classical (c) SDRs; Region: SDR_c; cd05233 956149005760 NAD(P) binding site [chemical binding]; other site 956149005761 active site 956149005762 LysR family transcriptional regulator; Provisional; Region: PRK14997 956149005763 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149005764 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 956149005765 putative effector binding pocket; other site 956149005766 putative dimerization interface [polypeptide binding]; other site 956149005767 sensor protein RstB; Provisional; Region: PRK10604 956149005768 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 956149005769 dimerization interface [polypeptide binding]; other site 956149005770 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 956149005771 dimer interface [polypeptide binding]; other site 956149005772 phosphorylation site [posttranslational modification] 956149005773 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 956149005774 ATP binding site [chemical binding]; other site 956149005775 Mg2+ binding site [ion binding]; other site 956149005776 G-X-G motif; other site 956149005777 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 956149005778 fumarate hydratase; Reviewed; Region: fumC; PRK00485 956149005779 Class II fumarases; Region: Fumarase_classII; cd01362 956149005780 active site 956149005781 tetramer interface [polypeptide binding]; other site 956149005782 fumarate hydratase; Provisional; Region: PRK15389 956149005783 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 956149005784 Fumarase C-terminus; Region: Fumerase_C; pfam05683 956149005785 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 956149005786 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 956149005787 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 956149005788 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 956149005789 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 956149005790 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 956149005791 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 956149005792 DNA binding site [nucleotide binding] 956149005793 domain linker motif; other site 956149005794 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 956149005795 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 956149005796 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 956149005797 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 956149005798 active site turn [active] 956149005799 phosphorylation site [posttranslational modification] 956149005800 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 956149005801 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 956149005802 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149005803 homodimer interface [polypeptide binding]; other site 956149005804 catalytic residue [active] 956149005805 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 956149005806 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 956149005807 active site 956149005808 purine riboside binding site [chemical binding]; other site 956149005809 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 956149005810 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 956149005811 putative oxidoreductase; Provisional; Region: PRK11579 956149005812 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 956149005813 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 956149005814 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 956149005815 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 956149005816 electron transport complex protein RsxA; Provisional; Region: PRK05151 956149005817 electron transport complex protein RnfB; Provisional; Region: PRK05113 956149005818 Putative Fe-S cluster; Region: FeS; pfam04060 956149005819 4Fe-4S binding domain; Region: Fer4; cl02805 956149005820 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 956149005821 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 956149005822 SLBB domain; Region: SLBB; pfam10531 956149005823 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 956149005824 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 956149005825 electron transport complex protein RnfG; Validated; Region: PRK01908 956149005826 electron transport complex RsxE subunit; Provisional; Region: PRK12405 956149005827 endonuclease III; Provisional; Region: PRK10702 956149005828 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 956149005829 minor groove reading motif; other site 956149005830 helix-hairpin-helix signature motif; other site 956149005831 substrate binding pocket [chemical binding]; other site 956149005832 active site 956149005833 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 956149005834 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 956149005835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149005836 putative substrate translocation pore; other site 956149005837 POT family; Region: PTR2; pfam00854 956149005838 glutathionine S-transferase; Provisional; Region: PRK10542 956149005839 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 956149005840 C-terminal domain interface [polypeptide binding]; other site 956149005841 GSH binding site (G-site) [chemical binding]; other site 956149005842 dimer interface [polypeptide binding]; other site 956149005843 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 956149005844 dimer interface [polypeptide binding]; other site 956149005845 N-terminal domain interface [polypeptide binding]; other site 956149005846 substrate binding pocket (H-site) [chemical binding]; other site 956149005847 pyridoxamine kinase; Validated; Region: PRK05756 956149005848 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 956149005849 dimer interface [polypeptide binding]; other site 956149005850 pyridoxal binding site [chemical binding]; other site 956149005851 ATP binding site [chemical binding]; other site 956149005852 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 956149005853 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 956149005854 active site 956149005855 HIGH motif; other site 956149005856 dimer interface [polypeptide binding]; other site 956149005857 KMSKS motif; other site 956149005858 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 956149005859 RNA binding surface [nucleotide binding]; other site 956149005860 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 956149005861 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 956149005862 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 956149005863 lysozyme inhibitor; Provisional; Region: PRK11372 956149005864 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 956149005865 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 956149005866 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 956149005867 transcriptional regulator SlyA; Provisional; Region: PRK03573 956149005868 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 956149005869 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 956149005870 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 956149005871 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 956149005872 HlyD family secretion protein; Region: HlyD_3; pfam13437 956149005873 Fusaric acid resistance protein family; Region: FUSC; pfam04632 956149005874 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 956149005875 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 956149005876 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 956149005877 E-class dimer interface [polypeptide binding]; other site 956149005878 P-class dimer interface [polypeptide binding]; other site 956149005879 active site 956149005880 Cu2+ binding site [ion binding]; other site 956149005881 Zn2+ binding site [ion binding]; other site 956149005882 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 956149005883 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 956149005884 active site 956149005885 catalytic tetrad [active] 956149005886 Predicted Fe-S protein [General function prediction only]; Region: COG3313 956149005887 putative metal dependent hydrolase; Provisional; Region: PRK11598 956149005888 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 956149005889 Sulfatase; Region: Sulfatase; pfam00884 956149005890 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 956149005891 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 956149005892 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 956149005893 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 956149005894 FMN binding site [chemical binding]; other site 956149005895 active site 956149005896 substrate binding site [chemical binding]; other site 956149005897 catalytic residue [active] 956149005898 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 956149005899 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 956149005900 dimer interface [polypeptide binding]; other site 956149005901 active site 956149005902 metal binding site [ion binding]; metal-binding site 956149005903 glutathione binding site [chemical binding]; other site 956149005904 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 956149005905 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 956149005906 dimer interface [polypeptide binding]; other site 956149005907 catalytic site [active] 956149005908 putative active site [active] 956149005909 putative substrate binding site [chemical binding]; other site 956149005910 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 956149005911 putative GSH binding site [chemical binding]; other site 956149005912 catalytic residues [active] 956149005913 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 956149005914 NlpC/P60 family; Region: NLPC_P60; pfam00877 956149005915 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149005916 Major Facilitator Superfamily; Region: MFS_1; pfam07690 956149005917 putative substrate translocation pore; other site 956149005918 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 956149005919 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 956149005920 DNA binding site [nucleotide binding] 956149005921 domain linker motif; other site 956149005922 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 956149005923 dimerization interface [polypeptide binding]; other site 956149005924 ligand binding site [chemical binding]; other site 956149005925 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 956149005926 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149005927 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 956149005928 dimerization interface [polypeptide binding]; other site 956149005929 putative transporter; Provisional; Region: PRK11043 956149005930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149005931 putative substrate translocation pore; other site 956149005932 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 956149005933 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 956149005934 S-adenosylmethionine binding site [chemical binding]; other site 956149005935 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 956149005936 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 956149005937 potential frameshift: common BLAST hit: gi|389841174|ref|YP_006343258.1| 6-phospho-beta-glucosidase 956149005938 Transcriptional regulators [Transcription]; Region: PurR; COG1609 956149005939 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 956149005940 DNA binding site [nucleotide binding] 956149005941 domain linker motif; other site 956149005942 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 956149005943 dimerization interface [polypeptide binding]; other site 956149005944 ligand binding site [chemical binding]; other site 956149005945 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 956149005946 Lumazine binding domain; Region: Lum_binding; pfam00677 956149005947 Lumazine binding domain; Region: Lum_binding; pfam00677 956149005948 multidrug efflux protein; Reviewed; Region: PRK01766 956149005949 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 956149005950 cation binding site [ion binding]; other site 956149005951 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 956149005952 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 956149005953 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 956149005954 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 956149005955 Protein of unknown function (DUF770); Region: DUF770; pfam05591 956149005956 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 956149005957 AAA domain; Region: AAA_28; pfam13521 956149005958 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 956149005959 Walker A motif; other site 956149005960 ATP binding site [chemical binding]; other site 956149005961 Walker B motif; other site 956149005962 choline transport protein BetT; Provisional; Region: PRK09928 956149005963 transcriptional regulator BetI; Validated; Region: PRK00767 956149005964 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 956149005965 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 956149005966 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 956149005967 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 956149005968 tetrameric interface [polypeptide binding]; other site 956149005969 NAD binding site [chemical binding]; other site 956149005970 catalytic residues [active] 956149005971 choline dehydrogenase; Validated; Region: PRK02106 956149005972 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 956149005973 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 956149005974 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149005975 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 956149005976 dimerization interface [polypeptide binding]; other site 956149005977 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 956149005978 Uncharacterized conserved protein [Function unknown]; Region: COG3791 956149005979 Sigma-S stabilisation anti-adaptor protein; Region: Anti-adapt_IraP; pfam10796 956149005980 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149005981 putative substrate translocation pore; other site 956149005982 Transcriptional regulator [Transcription]; Region: LysR; COG0583 956149005983 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149005984 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 956149005985 putative substrate binding pocket [chemical binding]; other site 956149005986 putative dimerization interface [polypeptide binding]; other site 956149005987 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 956149005988 molybdopterin cofactor binding site; other site 956149005989 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 956149005990 molybdopterin cofactor binding site; other site 956149005991 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 956149005992 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 956149005993 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 956149005994 HypF finger; Region: zf-HYPF; pfam07503 956149005995 HypF finger; Region: zf-HYPF; pfam07503 956149005996 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 956149005997 Acylphosphatase; Region: Acylphosphatase; pfam00708 956149005998 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 956149005999 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 956149006000 [4Fe-4S] binding site [ion binding]; other site 956149006001 molybdopterin cofactor binding site; other site 956149006002 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 956149006003 molybdopterin cofactor binding site; other site 956149006004 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 956149006005 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 956149006006 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 956149006007 nickel binding site [ion binding]; other site 956149006008 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 956149006009 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 956149006010 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 956149006011 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 956149006012 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 956149006013 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 956149006014 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 956149006015 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 956149006016 NADH dehydrogenase; Region: NADHdh; cl00469 956149006017 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 956149006018 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 956149006019 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 956149006020 Transcriptional repressor of hyc and hyp operons; Region: HycA_repressor; pfam11046 956149006021 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 956149006022 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 956149006023 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 956149006024 hydrogenase assembly chaperone; Provisional; Region: PRK10409 956149006025 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 956149006026 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 956149006027 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 956149006028 dimerization interface [polypeptide binding]; other site 956149006029 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 956149006030 ATP binding site [chemical binding]; other site 956149006031 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 956149006032 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 956149006033 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 956149006034 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 956149006035 Walker A motif; other site 956149006036 ATP binding site [chemical binding]; other site 956149006037 Walker B motif; other site 956149006038 arginine finger; other site 956149006039 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 956149006040 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 956149006041 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 956149006042 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 956149006043 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 956149006044 catalytic triad [active] 956149006045 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 956149006046 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 956149006047 non-specific DNA binding site [nucleotide binding]; other site 956149006048 salt bridge; other site 956149006049 sequence-specific DNA binding site [nucleotide binding]; other site 956149006050 Cupin domain; Region: Cupin_2; pfam07883 956149006051 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 956149006052 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 956149006053 NAD(P) binding site [chemical binding]; other site 956149006054 catalytic residues [active] 956149006055 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 956149006056 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 956149006057 hypothetical protein; Provisional; Region: PRK09945 956149006058 hypothetical protein; Provisional; Region: PRK09945 956149006059 hypothetical protein; Provisional; Region: PRK09945 956149006060 hypothetical protein; Provisional; Region: PRK09945 956149006061 hypothetical protein; Provisional; Region: PRK09945 956149006062 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 956149006063 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 956149006064 Autotransporter beta-domain; Region: Autotransporter; smart00869 956149006065 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 956149006066 pyruvate kinase; Provisional; Region: PRK09206 956149006067 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 956149006068 domain interfaces; other site 956149006069 active site 956149006070 murein lipoprotein; Provisional; Region: PRK15396 956149006071 L,D-transpeptidase; Provisional; Region: PRK10190 956149006072 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 956149006073 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 956149006074 cysteine desufuration protein SufE; Provisional; Region: PRK09296 956149006075 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 956149006076 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 956149006077 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 956149006078 catalytic residue [active] 956149006079 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 956149006080 FeS assembly protein SufD; Region: sufD; TIGR01981 956149006081 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 956149006082 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 956149006083 Walker A/P-loop; other site 956149006084 ATP binding site [chemical binding]; other site 956149006085 Q-loop/lid; other site 956149006086 ABC transporter signature motif; other site 956149006087 Walker B; other site 956149006088 D-loop; other site 956149006089 H-loop/switch region; other site 956149006090 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 956149006091 putative ABC transporter; Region: ycf24; CHL00085 956149006092 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 956149006093 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 956149006094 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 956149006095 catalytic core [active] 956149006096 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 956149006097 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 956149006098 CoenzymeA binding site [chemical binding]; other site 956149006099 subunit interaction site [polypeptide binding]; other site 956149006100 PHB binding site; other site 956149006101 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 956149006102 FAD binding domain; Region: FAD_binding_4; pfam01565 956149006103 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 956149006104 putative inner membrane protein; Provisional; Region: PRK10983 956149006105 Domain of unknown function DUF20; Region: UPF0118; pfam01594 956149006106 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 956149006107 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 956149006108 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 956149006109 putative symporter YagG; Provisional; Region: PRK09669 956149006110 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 956149006111 phosphoenolpyruvate synthase; Validated; Region: PRK06464 956149006112 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 956149006113 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 956149006114 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 956149006115 PEP synthetase regulatory protein; Provisional; Region: PRK05339 956149006116 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 956149006117 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 956149006118 hypothetical protein; Validated; Region: PRK00029 956149006119 Uncharacterized conserved protein [Function unknown]; Region: COG0397 956149006120 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 956149006121 Transcriptional regulators [Transcription]; Region: PurR; COG1609 956149006122 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 956149006123 DNA binding site [nucleotide binding] 956149006124 domain linker motif; other site 956149006125 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 956149006126 dimerization interface (closed form) [polypeptide binding]; other site 956149006127 ligand binding site [chemical binding]; other site 956149006128 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 956149006129 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 956149006130 NAD binding site [chemical binding]; other site 956149006131 sugar binding site [chemical binding]; other site 956149006132 divalent metal binding site [ion binding]; other site 956149006133 tetramer (dimer of dimers) interface [polypeptide binding]; other site 956149006134 dimer interface [polypeptide binding]; other site 956149006135 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 956149006136 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 956149006137 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 956149006138 NlpC/P60 family; Region: NLPC_P60; pfam00877 956149006139 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 956149006140 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 956149006141 Walker A/P-loop; other site 956149006142 ATP binding site [chemical binding]; other site 956149006143 Q-loop/lid; other site 956149006144 ABC transporter signature motif; other site 956149006145 Walker B; other site 956149006146 D-loop; other site 956149006147 H-loop/switch region; other site 956149006148 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 956149006149 catalytic residues [active] 956149006150 dimer interface [polypeptide binding]; other site 956149006151 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 956149006152 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 956149006153 dimer interface [polypeptide binding]; other site 956149006154 putative PBP binding regions; other site 956149006155 ABC-ATPase subunit interface; other site 956149006156 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 956149006157 IHF dimer interface [polypeptide binding]; other site 956149006158 IHF - DNA interface [nucleotide binding]; other site 956149006159 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 956149006160 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 956149006161 putative tRNA-binding site [nucleotide binding]; other site 956149006162 B3/4 domain; Region: B3_4; pfam03483 956149006163 tRNA synthetase B5 domain; Region: B5; smart00874 956149006164 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 956149006165 dimer interface [polypeptide binding]; other site 956149006166 motif 1; other site 956149006167 motif 3; other site 956149006168 motif 2; other site 956149006169 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 956149006170 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 956149006171 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 956149006172 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 956149006173 dimer interface [polypeptide binding]; other site 956149006174 motif 1; other site 956149006175 active site 956149006176 motif 2; other site 956149006177 motif 3; other site 956149006178 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 956149006179 23S rRNA binding site [nucleotide binding]; other site 956149006180 L21 binding site [polypeptide binding]; other site 956149006181 L13 binding site [polypeptide binding]; other site 956149006182 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 956149006183 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 956149006184 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 956149006185 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 956149006186 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 956149006187 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 956149006188 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 956149006189 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 956149006190 active site 956149006191 dimer interface [polypeptide binding]; other site 956149006192 motif 1; other site 956149006193 motif 2; other site 956149006194 motif 3; other site 956149006195 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 956149006196 anticodon binding site; other site 956149006197 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 956149006198 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 956149006199 Coenzyme A binding pocket [chemical binding]; other site 956149006200 Transcriptional regulator [Transcription]; Region: LysR; COG0583 956149006201 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149006202 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 956149006203 dimerization interface [polypeptide binding]; other site 956149006204 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 956149006205 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 956149006206 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 956149006207 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 956149006208 Coenzyme A binding pocket [chemical binding]; other site 956149006209 ecotin; Provisional; Region: PRK03719 956149006210 secondary substrate binding site; other site 956149006211 primary substrate binding site; other site 956149006212 inhibition loop; other site 956149006213 dimerization interface [polypeptide binding]; other site 956149006214 proline/glycine betaine transporter; Provisional; Region: PRK10642 956149006215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149006216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149006217 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 956149006218 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 956149006219 6-phosphofructokinase 2; Provisional; Region: PRK10294 956149006220 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 956149006221 putative substrate binding site [chemical binding]; other site 956149006222 putative ATP binding site [chemical binding]; other site 956149006223 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 956149006224 Fructosamine kinase; Region: Fructosamin_kin; pfam03881 956149006225 Phosphotransferase enzyme family; Region: APH; pfam01636 956149006226 YniB-like protein; Region: YniB; pfam14002 956149006227 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 956149006228 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 956149006229 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 956149006230 motif II; other site 956149006231 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 956149006232 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 956149006233 NADP binding site [chemical binding]; other site 956149006234 homodimer interface [polypeptide binding]; other site 956149006235 active site 956149006236 inner membrane protein; Provisional; Region: PRK11648 956149006237 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 956149006238 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 956149006239 cell division modulator; Provisional; Region: PRK10113 956149006240 hydroperoxidase II; Provisional; Region: katE; PRK11249 956149006241 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 956149006242 tetramer interface [polypeptide binding]; other site 956149006243 heme binding pocket [chemical binding]; other site 956149006244 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 956149006245 domain interactions; other site 956149006246 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 956149006247 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 956149006248 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 956149006249 homodimer interface [polypeptide binding]; other site 956149006250 NAD binding pocket [chemical binding]; other site 956149006251 ATP binding pocket [chemical binding]; other site 956149006252 Mg binding site [ion binding]; other site 956149006253 active-site loop [active] 956149006254 aromatic amino acid exporter; Provisional; Region: PRK11689 956149006255 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 956149006256 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 956149006257 GIY-YIG motif/motif A; other site 956149006258 active site 956149006259 catalytic site [active] 956149006260 putative DNA binding site [nucleotide binding]; other site 956149006261 metal binding site [ion binding]; metal-binding site 956149006262 HutD; Region: HutD; cl01532 956149006263 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 956149006264 dimer interface [polypeptide binding]; other site 956149006265 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 956149006266 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 956149006267 putative active site [active] 956149006268 Zn binding site [ion binding]; other site 956149006269 succinylarginine dihydrolase; Provisional; Region: PRK13281 956149006270 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 956149006271 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 956149006272 NAD(P) binding site [chemical binding]; other site 956149006273 catalytic residues [active] 956149006274 arginine succinyltransferase; Provisional; Region: PRK10456 956149006275 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 956149006276 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 956149006277 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 956149006278 inhibitor-cofactor binding pocket; inhibition site 956149006279 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149006280 catalytic residue [active] 956149006281 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 956149006282 putative catalytic site [active] 956149006283 putative phosphate binding site [ion binding]; other site 956149006284 active site 956149006285 metal binding site A [ion binding]; metal-binding site 956149006286 DNA binding site [nucleotide binding] 956149006287 putative AP binding site [nucleotide binding]; other site 956149006288 putative metal binding site B [ion binding]; other site 956149006289 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 956149006290 active site 956149006291 8-oxo-dGMP binding site [chemical binding]; other site 956149006292 nudix motif; other site 956149006293 metal binding site [ion binding]; metal-binding site 956149006294 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 956149006295 DNA topoisomerase III; Provisional; Region: PRK07726 956149006296 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 956149006297 active site 956149006298 putative interdomain interaction site [polypeptide binding]; other site 956149006299 putative metal-binding site [ion binding]; other site 956149006300 putative nucleotide binding site [chemical binding]; other site 956149006301 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 956149006302 domain I; other site 956149006303 DNA binding groove [nucleotide binding] 956149006304 phosphate binding site [ion binding]; other site 956149006305 domain II; other site 956149006306 domain III; other site 956149006307 nucleotide binding site [chemical binding]; other site 956149006308 catalytic site [active] 956149006309 domain IV; other site 956149006310 selenophosphate synthetase; Provisional; Region: PRK00943 956149006311 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 956149006312 dimerization interface [polypeptide binding]; other site 956149006313 putative ATP binding site [chemical binding]; other site 956149006314 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 956149006315 putative FMN binding site [chemical binding]; other site 956149006316 protease 4; Provisional; Region: PRK10949 956149006317 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 956149006318 tandem repeat interface [polypeptide binding]; other site 956149006319 oligomer interface [polypeptide binding]; other site 956149006320 active site residues [active] 956149006321 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 956149006322 tandem repeat interface [polypeptide binding]; other site 956149006323 oligomer interface [polypeptide binding]; other site 956149006324 active site residues [active] 956149006325 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 956149006326 active site 956149006327 homodimer interface [polypeptide binding]; other site 956149006328 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 956149006329 Isochorismatase family; Region: Isochorismatase; pfam00857 956149006330 catalytic triad [active] 956149006331 metal binding site [ion binding]; metal-binding site 956149006332 conserved cis-peptide bond; other site 956149006333 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 956149006334 methionine sulfoxide reductase B; Provisional; Region: PRK00222 956149006335 SelR domain; Region: SelR; pfam01641 956149006336 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 956149006337 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 956149006338 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 956149006339 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 956149006340 active site 956149006341 phosphate binding residues; other site 956149006342 catalytic residues [active] 956149006343 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 956149006344 PrkA family serine protein kinase; Provisional; Region: PRK15455 956149006345 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 956149006346 Walker A motif; other site 956149006347 ATP binding site [chemical binding]; other site 956149006348 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 956149006349 hypothetical protein; Provisional; Region: PRK05325 956149006350 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 956149006351 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 956149006352 General stress protein [General function prediction only]; Region: GsiB; COG3729 956149006353 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 956149006354 putative deacylase active site [active] 956149006355 Predicted membrane protein [Function unknown]; Region: COG2707 956149006356 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 956149006357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149006358 hypothetical protein; Validated; Region: PRK06186 956149006359 conserved cys residue [active] 956149006360 Uncharacterized conserved protein [Function unknown]; Region: COG3189 956149006361 Protein of unknown function (DUF535); Region: DUF535; pfam04393 956149006362 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 956149006363 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 956149006364 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 956149006365 active site 956149006366 phosphorylation site [posttranslational modification] 956149006367 intermolecular recognition site; other site 956149006368 dimerization interface [polypeptide binding]; other site 956149006369 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 956149006370 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 956149006371 DNA-binding site [nucleotide binding]; DNA binding site 956149006372 RNA-binding motif; other site 956149006373 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 956149006374 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 956149006375 Tar ligand binding domain homologue; Region: TarH; pfam02203 956149006376 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 956149006377 dimerization interface [polypeptide binding]; other site 956149006378 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 956149006379 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 956149006380 dimer interface [polypeptide binding]; other site 956149006381 putative CheW interface [polypeptide binding]; other site 956149006382 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 956149006383 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 956149006384 isocitrate dehydrogenase; Validated; Region: PRK07362 956149006385 isocitrate dehydrogenase; Reviewed; Region: PRK07006 956149006386 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 956149006387 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 956149006388 probable active site [active] 956149006389 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 956149006390 nudix motif; other site 956149006391 Cache domain; Region: Cache_1; pfam02743 956149006392 HAMP domain; Region: HAMP; pfam00672 956149006393 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 956149006394 dimer interface [polypeptide binding]; other site 956149006395 putative CheW interface [polypeptide binding]; other site 956149006396 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 956149006397 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 956149006398 putative lysogenization regulator; Reviewed; Region: PRK00218 956149006399 adenylosuccinate lyase; Provisional; Region: PRK09285 956149006400 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 956149006401 tetramer interface [polypeptide binding]; other site 956149006402 active site 956149006403 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 956149006404 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 956149006405 active site 956149006406 phosphorylation site [posttranslational modification] 956149006407 intermolecular recognition site; other site 956149006408 dimerization interface [polypeptide binding]; other site 956149006409 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 956149006410 DNA binding site [nucleotide binding] 956149006411 sensor protein PhoQ; Provisional; Region: PRK10815 956149006412 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 956149006413 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 956149006414 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 956149006415 ATP binding site [chemical binding]; other site 956149006416 Mg2+ binding site [ion binding]; other site 956149006417 G-X-G motif; other site 956149006418 Uncharacterized conserved protein [Function unknown]; Region: COG2850 956149006419 Cupin-like domain; Region: Cupin_8; pfam13621 956149006420 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 956149006421 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 956149006422 metal binding site [ion binding]; metal-binding site 956149006423 dimer interface [polypeptide binding]; other site 956149006424 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 956149006425 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 956149006426 Walker A/P-loop; other site 956149006427 ATP binding site [chemical binding]; other site 956149006428 Q-loop/lid; other site 956149006429 ABC transporter signature motif; other site 956149006430 Walker B; other site 956149006431 D-loop; other site 956149006432 H-loop/switch region; other site 956149006433 TOBE domain; Region: TOBE_2; pfam08402 956149006434 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 956149006435 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149006436 dimer interface [polypeptide binding]; other site 956149006437 conserved gate region; other site 956149006438 putative PBP binding loops; other site 956149006439 ABC-ATPase subunit interface; other site 956149006440 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 956149006441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149006442 dimer interface [polypeptide binding]; other site 956149006443 conserved gate region; other site 956149006444 putative PBP binding loops; other site 956149006445 ABC-ATPase subunit interface; other site 956149006446 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 956149006447 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 956149006448 NAD-dependent deacetylase; Provisional; Region: PRK00481 956149006449 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 956149006450 NAD+ binding site [chemical binding]; other site 956149006451 substrate binding site [chemical binding]; other site 956149006452 Zn binding site [ion binding]; other site 956149006453 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 956149006454 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 956149006455 nucleotide binding site [chemical binding]; other site 956149006456 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 956149006457 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 956149006458 FtsX-like permease family; Region: FtsX; pfam02687 956149006459 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 956149006460 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 956149006461 Walker A/P-loop; other site 956149006462 ATP binding site [chemical binding]; other site 956149006463 Q-loop/lid; other site 956149006464 ABC transporter signature motif; other site 956149006465 Walker B; other site 956149006466 D-loop; other site 956149006467 H-loop/switch region; other site 956149006468 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 956149006469 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 956149006470 FtsX-like permease family; Region: FtsX; pfam02687 956149006471 transcription-repair coupling factor; Provisional; Region: PRK10689 956149006472 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 956149006473 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 956149006474 ATP binding site [chemical binding]; other site 956149006475 putative Mg++ binding site [ion binding]; other site 956149006476 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 956149006477 nucleotide binding region [chemical binding]; other site 956149006478 ATP-binding site [chemical binding]; other site 956149006479 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 956149006480 L,D-transpeptidase; Provisional; Region: PRK10190 956149006481 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 956149006482 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 956149006483 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 956149006484 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 956149006485 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 956149006486 hypothetical protein; Provisional; Region: PRK11280 956149006487 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 956149006488 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 956149006489 hypothetical protein; Provisional; Region: PRK04940 956149006490 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 956149006491 beta-hexosaminidase; Provisional; Region: PRK05337 956149006492 thiamine kinase; Region: ycfN_thiK; TIGR02721 956149006493 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 956149006494 active site 956149006495 substrate binding site [chemical binding]; other site 956149006496 ATP binding site [chemical binding]; other site 956149006497 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 956149006498 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 956149006499 putative dimer interface [polypeptide binding]; other site 956149006500 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 956149006501 nucleotide binding site/active site [active] 956149006502 HIT family signature motif; other site 956149006503 catalytic residue [active] 956149006504 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 956149006505 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 956149006506 N-terminal plug; other site 956149006507 ligand-binding site [chemical binding]; other site 956149006508 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 956149006509 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 956149006510 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 956149006511 active site turn [active] 956149006512 phosphorylation site [posttranslational modification] 956149006513 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 956149006514 active site 956149006515 DNA polymerase III subunit delta'; Validated; Region: PRK07993 956149006516 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 956149006517 thymidylate kinase; Validated; Region: tmk; PRK00698 956149006518 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 956149006519 TMP-binding site; other site 956149006520 ATP-binding site [chemical binding]; other site 956149006521 conserved hypothetical protein, YceG family; Region: TIGR00247 956149006522 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 956149006523 dimerization interface [polypeptide binding]; other site 956149006524 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 956149006525 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 956149006526 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149006527 catalytic residue [active] 956149006528 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 956149006529 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 956149006530 dimer interface [polypeptide binding]; other site 956149006531 active site 956149006532 acyl carrier protein; Provisional; Region: acpP; PRK00982 956149006533 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 956149006534 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 956149006535 NAD(P) binding site [chemical binding]; other site 956149006536 homotetramer interface [polypeptide binding]; other site 956149006537 homodimer interface [polypeptide binding]; other site 956149006538 active site 956149006539 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 956149006540 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 956149006541 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 956149006542 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 956149006543 dimer interface [polypeptide binding]; other site 956149006544 active site 956149006545 CoA binding pocket [chemical binding]; other site 956149006546 putative phosphate acyltransferase; Provisional; Region: PRK05331 956149006547 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 956149006548 hypothetical protein; Provisional; Region: PRK11193 956149006549 Maf-like protein; Region: Maf; pfam02545 956149006550 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 956149006551 active site 956149006552 dimer interface [polypeptide binding]; other site 956149006553 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 956149006554 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 956149006555 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 956149006556 RNA binding surface [nucleotide binding]; other site 956149006557 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 956149006558 active site 956149006559 ribonuclease E; Reviewed; Region: rne; PRK10811 956149006560 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 956149006561 homodimer interface [polypeptide binding]; other site 956149006562 oligonucleotide binding site [chemical binding]; other site 956149006563 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 956149006564 Transcriptional regulator [Transcription]; Region: LysR; COG0583 956149006565 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149006566 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 956149006567 putative effector binding pocket; other site 956149006568 dimerization interface [polypeptide binding]; other site 956149006569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149006570 putative substrate translocation pore; other site 956149006571 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 956149006572 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 956149006573 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 956149006574 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 956149006575 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 956149006576 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 956149006577 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 956149006578 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 956149006579 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 956149006580 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 956149006581 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 956149006582 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 956149006583 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 956149006584 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 956149006585 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 956149006586 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 956149006587 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 956149006588 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 956149006589 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 956149006590 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 956149006591 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 956149006592 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 956149006593 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 956149006594 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 956149006595 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 956149006596 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 956149006597 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 956149006598 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 956149006599 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 956149006600 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 956149006601 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 956149006602 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 956149006603 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 956149006604 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 956149006605 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 956149006606 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 956149006607 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 956149006608 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 956149006609 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 956149006610 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 956149006611 hypothetical protein; Provisional; Region: PRK11239 956149006612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 956149006613 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 956149006614 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 956149006615 multidrug resistance protein MdtH; Provisional; Region: PRK11646 956149006616 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149006617 putative substrate translocation pore; other site 956149006618 glutaredoxin 2; Provisional; Region: PRK10387 956149006619 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 956149006620 C-terminal domain interface [polypeptide binding]; other site 956149006621 GSH binding site (G-site) [chemical binding]; other site 956149006622 catalytic residues [active] 956149006623 putative dimer interface [polypeptide binding]; other site 956149006624 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 956149006625 N-terminal domain interface [polypeptide binding]; other site 956149006626 lipoprotein; Provisional; Region: PRK10598 956149006627 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 956149006628 active site 956149006629 substrate binding pocket [chemical binding]; other site 956149006630 dimer interface [polypeptide binding]; other site 956149006631 DNA damage-inducible protein I; Provisional; Region: PRK10597 956149006632 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 956149006633 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 956149006634 hydroxyglutarate oxidase; Provisional; Region: PRK11728 956149006635 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 956149006636 hypothetical protein; Provisional; Region: PRK03757 956149006637 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 956149006638 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 956149006639 active site residue [active] 956149006640 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 956149006641 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 956149006642 putative acyl-acceptor binding pocket; other site 956149006643 secY/secA suppressor protein; Provisional; Region: PRK11467 956149006644 lipoprotein; Provisional; Region: PRK10175 956149006645 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 956149006646 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 956149006647 Ligand binding site; other site 956149006648 DXD motif; other site 956149006649 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 956149006650 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 956149006651 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 956149006652 Acyltransferase family; Region: Acyl_transf_3; pfam01757 956149006653 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 956149006654 putative active site [active] 956149006655 catalytic site [active] 956149006656 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 956149006657 PLD-like domain; Region: PLDc_2; pfam13091 956149006658 putative active site [active] 956149006659 catalytic site [active] 956149006660 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 956149006661 putative ADP-ribose binding site [chemical binding]; other site 956149006662 putative active site [active] 956149006663 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 956149006664 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 956149006665 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 956149006666 putative hydrolase; Validated; Region: PRK09248 956149006667 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 956149006668 active site 956149006669 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 956149006670 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 956149006671 putative ligand binding site [chemical binding]; other site 956149006672 NAD binding site [chemical binding]; other site 956149006673 dimerization interface [polypeptide binding]; other site 956149006674 catalytic site [active] 956149006675 Fimbrial protein; Region: Fimbrial; cl01416 956149006676 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 956149006677 PapC N-terminal domain; Region: PapC_N; pfam13954 956149006678 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 956149006679 PapC C-terminal domain; Region: PapC_C; pfam13953 956149006680 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 956149006681 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 956149006682 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 956149006683 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 956149006684 putative oxidoreductase; Provisional; Region: PRK09939 956149006685 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 956149006686 putative molybdopterin cofactor binding site [chemical binding]; other site 956149006687 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 956149006688 putative molybdopterin cofactor binding site; other site 956149006689 hypothetical protein; Provisional; Region: PRK10536 956149006690 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 956149006691 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 956149006692 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 956149006693 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 956149006694 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 956149006695 Imelysin; Region: Peptidase_M75; pfam09375 956149006696 FTR1 family protein; Region: TIGR00145 956149006697 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 956149006698 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 956149006699 Nucleoside recognition; Region: Gate; pfam07670 956149006700 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 956149006701 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 956149006702 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 956149006703 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 956149006704 Na binding site [ion binding]; other site 956149006705 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 956149006706 Predicted transcriptional regulator [Transcription]; Region: COG3905 956149006707 Proline dehydrogenase; Region: Pro_dh; pfam01619 956149006708 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 956149006709 Glutamate binding site [chemical binding]; other site 956149006710 NAD binding site [chemical binding]; other site 956149006711 catalytic residues [active] 956149006712 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 956149006713 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 956149006714 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 956149006715 pyrimidine utilization protein A; Region: RutA; TIGR03612 956149006716 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 956149006717 active site 956149006718 dimer interface [polypeptide binding]; other site 956149006719 non-prolyl cis peptide bond; other site 956149006720 insertion regions; other site 956149006721 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 956149006722 Isochorismatase family; Region: Isochorismatase; pfam00857 956149006723 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 956149006724 catalytic triad [active] 956149006725 conserved cis-peptide bond; other site 956149006726 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 956149006727 homotrimer interaction site [polypeptide binding]; other site 956149006728 putative active site [active] 956149006729 pyrimidine utilization protein D; Region: RutD; TIGR03611 956149006730 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 956149006731 putative FMN binding site [chemical binding]; other site 956149006732 Flavin Reductases; Region: FlaRed; cl00801 956149006733 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 956149006734 General stress protein [General function prediction only]; Region: GsiB; COG3729 956149006735 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 956149006736 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 956149006737 hypothetical protein; Provisional; Region: PRK10174 956149006738 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 956149006739 Transcriptional regulator [Transcription]; Region: LysR; COG0583 956149006740 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149006741 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 956149006742 dimerization interface [polypeptide binding]; other site 956149006743 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 956149006744 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 956149006745 ImpA domain protein; Region: DUF3702; pfam12486 956149006746 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 956149006747 potential frameshift: common BLAST hit: gi|389841475|ref|YP_006343559.1| type VI secretion system protein VasJ 956149006748 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 956149006749 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 956149006750 peptide binding site [polypeptide binding]; other site 956149006751 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 956149006752 YccA-like proteins; Region: YccA_like; cd10433 956149006753 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 956149006754 DsrC like protein; Region: DsrC; cl01101 956149006755 acylphosphatase; Provisional; Region: PRK14426 956149006756 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 956149006757 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 956149006758 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 956149006759 putative RNA binding site [nucleotide binding]; other site 956149006760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 956149006761 S-adenosylmethionine binding site [chemical binding]; other site 956149006762 heat shock protein HspQ; Provisional; Region: PRK14129 956149006763 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 956149006764 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 956149006765 active site 956149006766 dimer interfaces [polypeptide binding]; other site 956149006767 catalytic residues [active] 956149006768 DNA helicase IV; Provisional; Region: helD; PRK11054 956149006769 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 956149006770 Part of AAA domain; Region: AAA_19; pfam13245 956149006771 Family description; Region: UvrD_C_2; pfam13538 956149006772 Predicted membrane protein [Function unknown]; Region: COG3304 956149006773 Domain of unknown function (DUF307); Region: DUF307; pfam03733 956149006774 Domain of unknown function (DUF307); Region: DUF307; pfam03733 956149006775 TIGR01666 family membrane protein; Region: YCCS 956149006776 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 956149006777 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 956149006778 Prefoldin subunit; Region: Prefoldin_2; pfam01920 956149006779 TfoX N-terminal domain; Region: TfoX_N; pfam04993 956149006780 TfoX C-terminal domain; Region: TfoX_C; pfam04994 956149006781 SOS cell division inhibitor; Provisional; Region: PRK10595 956149006782 outer membrane protein A; Reviewed; Region: PRK10808 956149006783 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 956149006784 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 956149006785 ligand binding site [chemical binding]; other site 956149006786 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 956149006787 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 956149006788 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 956149006789 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 956149006790 active site 1 [active] 956149006791 dimer interface [polypeptide binding]; other site 956149006792 active site 2 [active] 956149006793 ribosome modulation factor; Provisional; Region: PRK14563 956149006794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 956149006795 Protein of unknown function (DUF330); Region: DUF330; pfam03886 956149006796 paraquat-inducible protein B; Provisional; Region: PRK10807 956149006797 mce related protein; Region: MCE; pfam02470 956149006798 mce related protein; Region: MCE; pfam02470 956149006799 mce related protein; Region: MCE; pfam02470 956149006800 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 956149006801 Paraquat-inducible protein A; Region: PqiA; pfam04403 956149006802 Paraquat-inducible protein A; Region: PqiA; pfam04403 956149006803 ABC transporter ATPase component; Reviewed; Region: PRK11147 956149006804 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 956149006805 Walker A/P-loop; other site 956149006806 ATP binding site [chemical binding]; other site 956149006807 Q-loop/lid; other site 956149006808 ABC transporter signature motif; other site 956149006809 Walker B; other site 956149006810 D-loop; other site 956149006811 H-loop/switch region; other site 956149006812 ABC transporter; Region: ABC_tran_2; pfam12848 956149006813 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 956149006814 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 956149006815 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 956149006816 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 956149006817 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 956149006818 S-adenosylmethionine binding site [chemical binding]; other site 956149006819 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 956149006820 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 956149006821 MOSC domain; Region: MOSC; pfam03473 956149006822 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 956149006823 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 956149006824 catalytic loop [active] 956149006825 iron binding site [ion binding]; other site 956149006826 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 956149006827 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 956149006828 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 956149006829 quinone interaction residues [chemical binding]; other site 956149006830 active site 956149006831 catalytic residues [active] 956149006832 FMN binding site [chemical binding]; other site 956149006833 substrate binding site [chemical binding]; other site 956149006834 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 956149006835 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 956149006836 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 956149006837 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 956149006838 substrate binding pocket [chemical binding]; other site 956149006839 membrane-bound complex binding site; other site 956149006840 hinge residues; other site 956149006841 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 956149006842 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 956149006843 active site 956149006844 dimer interface [polypeptide binding]; other site 956149006845 non-prolyl cis peptide bond; other site 956149006846 insertion regions; other site 956149006847 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 956149006848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149006849 dimer interface [polypeptide binding]; other site 956149006850 conserved gate region; other site 956149006851 putative PBP binding loops; other site 956149006852 ABC-ATPase subunit interface; other site 956149006853 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 956149006854 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 956149006855 Walker A/P-loop; other site 956149006856 ATP binding site [chemical binding]; other site 956149006857 Q-loop/lid; other site 956149006858 ABC transporter signature motif; other site 956149006859 Walker B; other site 956149006860 D-loop; other site 956149006861 H-loop/switch region; other site 956149006862 aminopeptidase N; Provisional; Region: pepN; PRK14015 956149006863 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 956149006864 active site 956149006865 Zn binding site [ion binding]; other site 956149006866 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 956149006867 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 956149006868 active site 956149006869 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 956149006870 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 956149006871 putative dimer interface [polypeptide binding]; other site 956149006872 putative anticodon binding site; other site 956149006873 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 956149006874 homodimer interface [polypeptide binding]; other site 956149006875 motif 1; other site 956149006876 motif 2; other site 956149006877 active site 956149006878 motif 3; other site 956149006879 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 956149006880 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 956149006881 eyelet of channel; other site 956149006882 trimer interface [polypeptide binding]; other site 956149006883 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 956149006884 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 956149006885 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149006886 homodimer interface [polypeptide binding]; other site 956149006887 catalytic residue [active] 956149006888 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 956149006889 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 956149006890 Peptidase M15; Region: Peptidase_M15_3; cl01194 956149006891 murein L,D-transpeptidase; Provisional; Region: PRK10594 956149006892 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 956149006893 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 956149006894 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 956149006895 cell division protein MukB; Provisional; Region: mukB; PRK04863 956149006896 P-loop containing region of AAA domain; Region: AAA_29; cl17516 956149006897 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 956149006898 condesin subunit E; Provisional; Region: PRK05256 956149006899 condesin subunit F; Provisional; Region: PRK05260 956149006900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 956149006901 S-adenosylmethionine binding site [chemical binding]; other site 956149006902 Methyltransferase domain; Region: Methyltransf_31; pfam13847 956149006903 Uncharacterized conserved protein [Function unknown]; Region: COG1434 956149006904 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 956149006905 putative active site [active] 956149006906 hypothetical protein; Provisional; Region: PRK10593 956149006907 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 956149006908 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 956149006909 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 956149006910 AsnC family; Region: AsnC_trans_reg; pfam01037 956149006911 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 956149006912 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 956149006913 Ligand binding site; other site 956149006914 oligomer interface; other site 956149006915 Trm112p-like protein; Region: Trm112p; cl01066 956149006916 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 956149006917 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 956149006918 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 956149006919 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 956149006920 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 956149006921 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 956149006922 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 956149006923 Walker A/P-loop; other site 956149006924 ATP binding site [chemical binding]; other site 956149006925 Q-loop/lid; other site 956149006926 ABC transporter signature motif; other site 956149006927 Walker B; other site 956149006928 D-loop; other site 956149006929 H-loop/switch region; other site 956149006930 ComEC family competence protein; Provisional; Region: PRK11539 956149006931 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 956149006932 Competence protein; Region: Competence; pfam03772 956149006933 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 956149006934 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 956149006935 IHF dimer interface [polypeptide binding]; other site 956149006936 IHF - DNA interface [nucleotide binding]; other site 956149006937 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 956149006938 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 956149006939 RNA binding site [nucleotide binding]; other site 956149006940 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 956149006941 RNA binding site [nucleotide binding]; other site 956149006942 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 956149006943 RNA binding site [nucleotide binding]; other site 956149006944 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 956149006945 RNA binding site [nucleotide binding]; other site 956149006946 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 956149006947 RNA binding site [nucleotide binding]; other site 956149006948 cytidylate kinase; Provisional; Region: cmk; PRK00023 956149006949 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 956149006950 CMP-binding site; other site 956149006951 The sites determining sugar specificity; other site 956149006952 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 956149006953 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 956149006954 hinge; other site 956149006955 active site 956149006956 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 956149006957 homodimer interface [polypeptide binding]; other site 956149006958 substrate-cofactor binding pocket; other site 956149006959 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149006960 catalytic residue [active] 956149006961 Predicted membrane protein [Function unknown]; Region: COG2323 956149006962 uncharacterized domain; Region: TIGR00702 956149006963 YcaO-like family; Region: YcaO; pfam02624 956149006964 formate transporter; Provisional; Region: PRK10805 956149006965 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 956149006966 Pyruvate formate lyase 1; Region: PFL1; cd01678 956149006967 coenzyme A binding site [chemical binding]; other site 956149006968 active site 956149006969 catalytic residues [active] 956149006970 glycine loop; other site 956149006971 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 956149006972 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 956149006973 FeS/SAM binding site; other site 956149006974 putative MFS family transporter protein; Provisional; Region: PRK03633 956149006975 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149006976 putative substrate translocation pore; other site 956149006977 seryl-tRNA synthetase; Provisional; Region: PRK05431 956149006978 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 956149006979 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 956149006980 dimer interface [polypeptide binding]; other site 956149006981 active site 956149006982 motif 1; other site 956149006983 motif 2; other site 956149006984 motif 3; other site 956149006985 recombination factor protein RarA; Reviewed; Region: PRK13342 956149006986 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 956149006987 Walker A motif; other site 956149006988 ATP binding site [chemical binding]; other site 956149006989 Walker B motif; other site 956149006990 arginine finger; other site 956149006991 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 956149006992 periplasmic chaperone LolA; Region: lolA; TIGR00547 956149006993 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 956149006994 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 956149006995 DNA translocase FtsK; Provisional; Region: PRK10263 956149006996 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 956149006997 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 956149006998 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 956149006999 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 956149007000 putative DNA binding site [nucleotide binding]; other site 956149007001 putative Zn2+ binding site [ion binding]; other site 956149007002 AsnC family; Region: AsnC_trans_reg; pfam01037 956149007003 thioredoxin reductase; Provisional; Region: PRK10262 956149007004 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 956149007005 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 956149007006 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 956149007007 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 956149007008 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 956149007009 Walker A/P-loop; other site 956149007010 ATP binding site [chemical binding]; other site 956149007011 Q-loop/lid; other site 956149007012 ABC transporter signature motif; other site 956149007013 Walker B; other site 956149007014 D-loop; other site 956149007015 H-loop/switch region; other site 956149007016 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 956149007017 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 956149007018 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 956149007019 Walker A/P-loop; other site 956149007020 ATP binding site [chemical binding]; other site 956149007021 Q-loop/lid; other site 956149007022 ABC transporter signature motif; other site 956149007023 Walker B; other site 956149007024 D-loop; other site 956149007025 H-loop/switch region; other site 956149007026 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 956149007027 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 956149007028 rRNA binding site [nucleotide binding]; other site 956149007029 predicted 30S ribosome binding site; other site 956149007030 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 956149007031 Clp amino terminal domain; Region: Clp_N; pfam02861 956149007032 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 956149007033 Walker A motif; other site 956149007034 ATP binding site [chemical binding]; other site 956149007035 Walker B motif; other site 956149007036 arginine finger; other site 956149007037 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 956149007038 Walker A motif; other site 956149007039 ATP binding site [chemical binding]; other site 956149007040 Walker B motif; other site 956149007041 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 956149007042 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 956149007043 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 956149007044 DNA-binding site [nucleotide binding]; DNA binding site 956149007045 RNA-binding motif; other site 956149007046 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 956149007047 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 956149007048 Walker A/P-loop; other site 956149007049 ATP binding site [chemical binding]; other site 956149007050 Q-loop/lid; other site 956149007051 ABC transporter signature motif; other site 956149007052 Walker B; other site 956149007053 D-loop; other site 956149007054 H-loop/switch region; other site 956149007055 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 956149007056 FtsX-like permease family; Region: FtsX; pfam02687 956149007057 macrolide transporter subunit MacA; Provisional; Region: PRK11578 956149007058 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 956149007059 HlyD family secretion protein; Region: HlyD_3; pfam13437 956149007060 Protein of unknown function (DUF535); Region: DUF535; pfam04393 956149007061 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 956149007062 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 956149007063 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 956149007064 putative active site [active] 956149007065 putative metal-binding site [ion binding]; other site 956149007066 Predicted membrane protein [Function unknown]; Region: COG2431 956149007067 hybrid cluster protein; Provisional; Region: PRK05290 956149007068 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 956149007069 ACS interaction site; other site 956149007070 CODH interaction site; other site 956149007071 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 956149007072 hybrid metal cluster; other site 956149007073 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 956149007074 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 956149007075 FAD binding pocket [chemical binding]; other site 956149007076 FAD binding motif [chemical binding]; other site 956149007077 phosphate binding motif [ion binding]; other site 956149007078 beta-alpha-beta structure motif; other site 956149007079 NAD binding pocket [chemical binding]; other site 956149007080 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 956149007081 catalytic loop [active] 956149007082 iron binding site [ion binding]; other site 956149007083 pyruvate dehydrogenase; Provisional; Region: PRK09124 956149007084 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 956149007085 PYR/PP interface [polypeptide binding]; other site 956149007086 dimer interface [polypeptide binding]; other site 956149007087 tetramer interface [polypeptide binding]; other site 956149007088 TPP binding site [chemical binding]; other site 956149007089 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 956149007090 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 956149007091 TPP-binding site [chemical binding]; other site 956149007092 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 956149007093 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 956149007094 tetramer interface [polypeptide binding]; other site 956149007095 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149007096 catalytic residue [active] 956149007097 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 956149007098 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 956149007099 NAD(P) binding site [chemical binding]; other site 956149007100 active site 956149007101 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 956149007102 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 956149007103 amidase catalytic site [active] 956149007104 Zn binding residues [ion binding]; other site 956149007105 substrate binding site [chemical binding]; other site 956149007106 hypothetical protein; Provisional; Region: PRK02877 956149007107 putative lipoprotein; Provisional; Region: PRK10533 956149007108 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 956149007109 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 956149007110 Walker A/P-loop; other site 956149007111 ATP binding site [chemical binding]; other site 956149007112 Q-loop/lid; other site 956149007113 ABC transporter signature motif; other site 956149007114 Walker B; other site 956149007115 D-loop; other site 956149007116 H-loop/switch region; other site 956149007117 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 956149007118 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 956149007119 substrate binding pocket [chemical binding]; other site 956149007120 membrane-bound complex binding site; other site 956149007121 hinge residues; other site 956149007122 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 956149007123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149007124 dimer interface [polypeptide binding]; other site 956149007125 conserved gate region; other site 956149007126 putative PBP binding loops; other site 956149007127 ABC-ATPase subunit interface; other site 956149007128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149007129 dimer interface [polypeptide binding]; other site 956149007130 conserved gate region; other site 956149007131 putative PBP binding loops; other site 956149007132 ABC-ATPase subunit interface; other site 956149007133 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 956149007134 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 956149007135 substrate binding pocket [chemical binding]; other site 956149007136 membrane-bound complex binding site; other site 956149007137 hinge residues; other site 956149007138 Cupin domain; Region: Cupin_2; pfam07883 956149007139 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 956149007140 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 956149007141 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 956149007142 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 956149007143 galactoside permease; Reviewed; Region: lacY; PRK09528 956149007144 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149007145 putative substrate translocation pore; other site 956149007146 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 956149007147 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 956149007148 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 956149007149 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 956149007150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149007151 dimer interface [polypeptide binding]; other site 956149007152 conserved gate region; other site 956149007153 putative PBP binding loops; other site 956149007154 ABC-ATPase subunit interface; other site 956149007155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149007156 dimer interface [polypeptide binding]; other site 956149007157 conserved gate region; other site 956149007158 putative PBP binding loops; other site 956149007159 ABC-ATPase subunit interface; other site 956149007160 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 956149007161 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 956149007162 Walker A/P-loop; other site 956149007163 ATP binding site [chemical binding]; other site 956149007164 Q-loop/lid; other site 956149007165 ABC transporter signature motif; other site 956149007166 Walker B; other site 956149007167 D-loop; other site 956149007168 H-loop/switch region; other site 956149007169 TOBE domain; Region: TOBE_2; pfam08402 956149007170 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 956149007171 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 956149007172 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 956149007173 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 956149007174 RimK-like ATP-grasp domain; Region: RimK; pfam08443 956149007175 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 956149007176 dimer interface [polypeptide binding]; other site 956149007177 FMN binding site [chemical binding]; other site 956149007178 NADPH bind site [chemical binding]; other site 956149007179 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 956149007180 putative transporter; Provisional; Region: PRK04972 956149007181 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 956149007182 TrkA-C domain; Region: TrkA_C; pfam02080 956149007183 TrkA-C domain; Region: TrkA_C; pfam02080 956149007184 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 956149007185 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 956149007186 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 956149007187 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149007188 putative substrate translocation pore; other site 956149007189 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 956149007190 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 956149007191 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 956149007192 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 956149007193 active site 956149007194 motif I; other site 956149007195 motif II; other site 956149007196 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 956149007197 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 956149007198 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149007199 putative substrate translocation pore; other site 956149007200 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 956149007201 active site 956149007202 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 956149007203 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 956149007204 active site 956149007205 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 956149007206 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 956149007207 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 956149007208 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 956149007209 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 956149007210 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 956149007211 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 956149007212 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 956149007213 putative C-terminal domain interface [polypeptide binding]; other site 956149007214 putative GSH binding site (G-site) [chemical binding]; other site 956149007215 putative dimer interface [polypeptide binding]; other site 956149007216 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 956149007217 putative N-terminal domain interface [polypeptide binding]; other site 956149007218 putative dimer interface [polypeptide binding]; other site 956149007219 putative substrate binding pocket (H-site) [chemical binding]; other site 956149007220 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 956149007221 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 956149007222 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 956149007223 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 956149007224 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 956149007225 FeS/SAM binding site; other site 956149007226 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 956149007227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149007228 dimer interface [polypeptide binding]; other site 956149007229 conserved gate region; other site 956149007230 putative PBP binding loops; other site 956149007231 ABC-ATPase subunit interface; other site 956149007232 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 956149007233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149007234 dimer interface [polypeptide binding]; other site 956149007235 conserved gate region; other site 956149007236 putative PBP binding loops; other site 956149007237 ABC-ATPase subunit interface; other site 956149007238 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 956149007239 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 956149007240 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 956149007241 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 956149007242 Walker A/P-loop; other site 956149007243 ATP binding site [chemical binding]; other site 956149007244 Q-loop/lid; other site 956149007245 ABC transporter signature motif; other site 956149007246 Walker B; other site 956149007247 D-loop; other site 956149007248 H-loop/switch region; other site 956149007249 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 956149007250 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 956149007251 Walker A/P-loop; other site 956149007252 ATP binding site [chemical binding]; other site 956149007253 Q-loop/lid; other site 956149007254 ABC transporter signature motif; other site 956149007255 Walker B; other site 956149007256 D-loop; other site 956149007257 H-loop/switch region; other site 956149007258 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 956149007259 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 956149007260 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 956149007261 dimer interface [polypeptide binding]; other site 956149007262 putative functional site; other site 956149007263 putative MPT binding site; other site 956149007264 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 956149007265 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 956149007266 ATP binding site [chemical binding]; other site 956149007267 substrate interface [chemical binding]; other site 956149007268 Transcriptional regulators [Transcription]; Region: PurR; COG1609 956149007269 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 956149007270 DNA binding site [nucleotide binding] 956149007271 domain linker motif; other site 956149007272 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 956149007273 ligand binding site [chemical binding]; other site 956149007274 dimerization interface [polypeptide binding]; other site 956149007275 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149007276 D-galactonate transporter; Region: 2A0114; TIGR00893 956149007277 putative substrate translocation pore; other site 956149007278 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 956149007279 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 956149007280 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 956149007281 putative active site [active] 956149007282 putative catalytic site [active] 956149007283 haemagglutination activity domain; Region: Haemagg_act; pfam05860 956149007284 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 956149007285 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 956149007286 Walker A/P-loop; other site 956149007287 ATP binding site [chemical binding]; other site 956149007288 Q-loop/lid; other site 956149007289 ABC transporter signature motif; other site 956149007290 Walker B; other site 956149007291 D-loop; other site 956149007292 H-loop/switch region; other site 956149007293 ABC transporter; Region: ABC_tran_2; pfam12848 956149007294 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 956149007295 L,D-transpeptidase; Provisional; Region: PRK10260 956149007296 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 956149007297 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 956149007298 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 956149007299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149007300 putative substrate translocation pore; other site 956149007301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149007302 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 956149007303 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 956149007304 HlyD family secretion protein; Region: HlyD_3; pfam13437 956149007305 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 956149007306 transmembrane helices; other site 956149007307 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 956149007308 manganese transport regulator MntR; Provisional; Region: PRK11050 956149007309 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 956149007310 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 956149007311 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 956149007312 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 956149007313 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 956149007314 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 956149007315 Baseplate J-like protein; Region: Baseplate_J; cl01294 956149007316 Baseplate J-like protein; Region: Baseplate_J; cl01294 956149007317 Protein of unknown function (DUF2590); Region: DUF2590; pfam10761 956149007318 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 956149007319 Protein of unknown function (DUF2765); Region: DUF2765; pfam10963 956149007320 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 956149007321 Phage holin family 2; Region: Phage_holin_2; pfam04550 956149007322 Protein of unknown function (DUF2597); Region: DUF2597; pfam10772 956149007323 Protein of unknown function (DUF2586); Region: DUF2586; pfam10758 956149007324 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 956149007325 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 956149007326 terminase endonuclease subunit; Provisional; Region: M; PHA02537 956149007327 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 956149007328 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 956149007329 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 956149007330 terminase ATPase subunit; Provisional; Region: P; PHA02535 956149007331 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 956149007332 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 956149007333 Phage-related protein [Function unknown]; Region: COG4695; cl01923 956149007334 Phage portal protein; Region: Phage_portal; pfam04860 956149007335 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 956149007336 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 956149007337 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 956149007338 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 956149007339 Protein of unknown function (DUF2724); Region: DUF2724; pfam10893 956149007340 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 956149007341 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 956149007342 integrase; Provisional; Region: int; PHA02601 956149007343 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 956149007344 active site 956149007345 DNA binding site [nucleotide binding] 956149007346 Int/Topo IB signature motif; other site 956149007347 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 956149007348 Sulfatase; Region: Sulfatase; pfam00884 956149007349 outer membrane protein X; Provisional; Region: ompX; PRK09408 956149007350 threonine and homoserine efflux system; Provisional; Region: PRK10532 956149007351 EamA-like transporter family; Region: EamA; pfam00892 956149007352 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 956149007353 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 956149007354 dimerization interface [polypeptide binding]; other site 956149007355 DPS ferroxidase diiron center [ion binding]; other site 956149007356 ion pore; other site 956149007357 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 956149007358 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 956149007359 substrate binding pocket [chemical binding]; other site 956149007360 membrane-bound complex binding site; other site 956149007361 hinge residues; other site 956149007362 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 956149007363 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149007364 dimer interface [polypeptide binding]; other site 956149007365 conserved gate region; other site 956149007366 putative PBP binding loops; other site 956149007367 ABC-ATPase subunit interface; other site 956149007368 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 956149007369 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 956149007370 Walker A/P-loop; other site 956149007371 ATP binding site [chemical binding]; other site 956149007372 Q-loop/lid; other site 956149007373 ABC transporter signature motif; other site 956149007374 Walker B; other site 956149007375 D-loop; other site 956149007376 H-loop/switch region; other site 956149007377 putative mechanosensitive channel protein; Provisional; Region: PRK11465 956149007378 Mechanosensitive ion channel; Region: MS_channel; pfam00924 956149007379 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 956149007380 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 956149007381 S-adenosylmethionine binding site [chemical binding]; other site 956149007382 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 956149007383 hypothetical protein; Provisional; Region: PRK11019 956149007384 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 956149007385 glycosyl transferase family protein; Provisional; Region: PRK08136 956149007386 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 956149007387 Fimbrial protein; Region: Fimbrial; cl01416 956149007388 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 956149007389 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 956149007390 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 956149007391 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 956149007392 PapC N-terminal domain; Region: PapC_N; pfam13954 956149007393 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 956149007394 PapC C-terminal domain; Region: PapC_C; pfam13953 956149007395 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 956149007396 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 956149007397 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 956149007398 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 956149007399 DEAD_2; Region: DEAD_2; pfam06733 956149007400 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 956149007401 transcriptional antiterminator BglG; Provisional; Region: PRK09772 956149007402 CAT RNA binding domain; Region: CAT_RBD; smart01061 956149007403 PRD domain; Region: PRD; pfam00874 956149007404 PRD domain; Region: PRD; pfam00874 956149007405 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 956149007406 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 956149007407 active site turn [active] 956149007408 phosphorylation site [posttranslational modification] 956149007409 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 956149007410 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 956149007411 HPr interaction site; other site 956149007412 glycerol kinase (GK) interaction site [polypeptide binding]; other site 956149007413 active site 956149007414 phosphorylation site [posttranslational modification] 956149007415 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 956149007416 beta-galactosidase; Region: BGL; TIGR03356 956149007417 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 956149007418 beta-galactosidase; Region: BGL; TIGR03356 956149007419 helicase 45; Provisional; Region: PTZ00424 956149007420 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 956149007421 ATP binding site [chemical binding]; other site 956149007422 Mg++ binding site [ion binding]; other site 956149007423 motif III; other site 956149007424 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 956149007425 nucleotide binding region [chemical binding]; other site 956149007426 ATP-binding site [chemical binding]; other site 956149007427 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 956149007428 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 956149007429 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 956149007430 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 956149007431 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 956149007432 HlyD family secretion protein; Region: HlyD_3; pfam13437 956149007433 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 956149007434 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 956149007435 Walker A/P-loop; other site 956149007436 ATP binding site [chemical binding]; other site 956149007437 Q-loop/lid; other site 956149007438 ABC transporter signature motif; other site 956149007439 Walker B; other site 956149007440 D-loop; other site 956149007441 H-loop/switch region; other site 956149007442 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 956149007443 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 956149007444 Walker A/P-loop; other site 956149007445 ATP binding site [chemical binding]; other site 956149007446 Q-loop/lid; other site 956149007447 ABC transporter signature motif; other site 956149007448 Walker B; other site 956149007449 D-loop; other site 956149007450 H-loop/switch region; other site 956149007451 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 956149007452 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 956149007453 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 956149007454 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 956149007455 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 956149007456 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 956149007457 putative catalytic site [active] 956149007458 putative metal binding site [ion binding]; other site 956149007459 putative phosphate binding site [ion binding]; other site 956149007460 cardiolipin synthase 2; Provisional; Region: PRK11263 956149007461 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 956149007462 putative active site [active] 956149007463 catalytic site [active] 956149007464 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 956149007465 putative active site [active] 956149007466 catalytic site [active] 956149007467 Predicted integral membrane protein [Function unknown]; Region: COG0392 956149007468 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 956149007469 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 956149007470 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 956149007471 MoaE homodimer interface [polypeptide binding]; other site 956149007472 MoaD interaction [polypeptide binding]; other site 956149007473 active site residues [active] 956149007474 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 956149007475 MoaE interaction surface [polypeptide binding]; other site 956149007476 MoeB interaction surface [polypeptide binding]; other site 956149007477 thiocarboxylated glycine; other site 956149007478 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 956149007479 trimer interface [polypeptide binding]; other site 956149007480 dimer interface [polypeptide binding]; other site 956149007481 putative active site [active] 956149007482 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 956149007483 MPT binding site; other site 956149007484 trimer interface [polypeptide binding]; other site 956149007485 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 956149007486 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 956149007487 FeS/SAM binding site; other site 956149007488 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 956149007489 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 956149007490 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 956149007491 phosphate binding site [ion binding]; other site 956149007492 putative substrate binding pocket [chemical binding]; other site 956149007493 dimer interface [polypeptide binding]; other site 956149007494 excinuclease ABC subunit B; Provisional; Region: PRK05298 956149007495 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 956149007496 ATP binding site [chemical binding]; other site 956149007497 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 956149007498 nucleotide binding region [chemical binding]; other site 956149007499 ATP-binding site [chemical binding]; other site 956149007500 Ultra-violet resistance protein B; Region: UvrB; pfam12344 956149007501 UvrB/uvrC motif; Region: UVR; pfam02151 956149007502 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 956149007503 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 956149007504 Walker A/P-loop; other site 956149007505 ATP binding site [chemical binding]; other site 956149007506 Q-loop/lid; other site 956149007507 ABC transporter signature motif; other site 956149007508 Walker B; other site 956149007509 D-loop; other site 956149007510 H-loop/switch region; other site 956149007511 AAA domain; Region: AAA_26; pfam13500 956149007512 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 956149007513 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 956149007514 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 956149007515 S-adenosylmethionine binding site [chemical binding]; other site 956149007516 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 956149007517 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 956149007518 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 956149007519 catalytic residue [active] 956149007520 biotin synthase; Provisional; Region: PRK15108 956149007521 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 956149007522 FeS/SAM binding site; other site 956149007523 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 956149007524 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 956149007525 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 956149007526 inhibitor-cofactor binding pocket; inhibition site 956149007527 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149007528 catalytic residue [active] 956149007529 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 956149007530 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 956149007531 potential catalytic triad [active] 956149007532 conserved cys residue [active] 956149007533 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 956149007534 substrate binding site [chemical binding]; other site 956149007535 acyl-CoA thioesterase; Provisional; Region: PRK10531 956149007536 putative pectinesterase; Region: PLN02432; cl01911 956149007537 6-phosphogluconolactonase; Provisional; Region: PRK11028 956149007538 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 956149007539 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 956149007540 active site 956149007541 motif I; other site 956149007542 motif II; other site 956149007543 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 956149007544 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 956149007545 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 956149007546 Walker A/P-loop; other site 956149007547 ATP binding site [chemical binding]; other site 956149007548 Q-loop/lid; other site 956149007549 ABC transporter signature motif; other site 956149007550 Walker B; other site 956149007551 D-loop; other site 956149007552 H-loop/switch region; other site 956149007553 molybdenum-pterin binding domain; Region: Mop; TIGR00638 956149007554 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 956149007555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149007556 dimer interface [polypeptide binding]; other site 956149007557 conserved gate region; other site 956149007558 putative PBP binding loops; other site 956149007559 ABC-ATPase subunit interface; other site 956149007560 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 956149007561 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 956149007562 substrate binding pocket [chemical binding]; other site 956149007563 membrane-bound complex binding site; other site 956149007564 hinge residues; other site 956149007565 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 956149007566 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 956149007567 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 956149007568 molybdenum-pterin binding domain; Region: Mop; TIGR00638 956149007569 TOBE domain; Region: TOBE; pfam03459 956149007570 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 956149007571 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 956149007572 Walker A/P-loop; other site 956149007573 ATP binding site [chemical binding]; other site 956149007574 ABC transporter signature motif; other site 956149007575 Walker B; other site 956149007576 D-loop; other site 956149007577 H-loop/switch region; other site 956149007578 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 956149007579 Walker A/P-loop; other site 956149007580 ATP binding site [chemical binding]; other site 956149007581 Q-loop/lid; other site 956149007582 ABC transporter signature motif; other site 956149007583 Walker B; other site 956149007584 D-loop; other site 956149007585 H-loop/switch region; other site 956149007586 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 956149007587 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 956149007588 NAD binding site [chemical binding]; other site 956149007589 homodimer interface [polypeptide binding]; other site 956149007590 active site 956149007591 substrate binding site [chemical binding]; other site 956149007592 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 956149007593 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 956149007594 dimer interface [polypeptide binding]; other site 956149007595 active site 956149007596 galactokinase; Provisional; Region: PRK05101 956149007597 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 956149007598 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 956149007599 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 956149007600 active site 956149007601 catalytic residues [active] 956149007602 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 956149007603 catalytic core [active] 956149007604 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 956149007605 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 956149007606 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 956149007607 zinc transporter ZitB; Provisional; Region: PRK03557 956149007608 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 956149007609 quinolinate synthetase; Provisional; Region: PRK09375 956149007610 tol-pal system protein YbgF; Provisional; Region: PRK10803 956149007611 Tetratricopeptide repeat; Region: TPR_6; pfam13174 956149007612 Tetratricopeptide repeat; Region: TPR_6; pfam13174 956149007613 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 956149007614 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 956149007615 ligand binding site [chemical binding]; other site 956149007616 translocation protein TolB; Provisional; Region: tolB; PRK03629 956149007617 TolB amino-terminal domain; Region: TolB_N; pfam04052 956149007618 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 956149007619 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 956149007620 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 956149007621 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 956149007622 TolA C-terminal; Region: TolA; pfam06519 956149007623 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 956149007624 colicin uptake protein TolR; Provisional; Region: PRK11024 956149007625 colicin uptake protein TolQ; Provisional; Region: PRK10801 956149007626 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 956149007627 active site 956149007628 hypothetical protein; Provisional; Region: PRK10588 956149007629 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 956149007630 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 956149007631 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 956149007632 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 956149007633 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 956149007634 alpha-mannosidase; Provisional; Region: PRK09819 956149007635 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 956149007636 active site 956149007637 metal binding site [ion binding]; metal-binding site 956149007638 catalytic site [active] 956149007639 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 956149007640 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 956149007641 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 956149007642 active site 956149007643 phosphorylation site [posttranslational modification] 956149007644 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 956149007645 active site 956149007646 P-loop; other site 956149007647 phosphorylation site [posttranslational modification] 956149007648 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 956149007649 DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764 956149007650 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 956149007651 DNA-binding site [nucleotide binding]; DNA binding site 956149007652 UTRA domain; Region: UTRA; pfam07702 956149007653 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 956149007654 CoA binding domain; Region: CoA_binding; smart00881 956149007655 CoA-ligase; Region: Ligase_CoA; pfam00549 956149007656 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 956149007657 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 956149007658 CoA-ligase; Region: Ligase_CoA; pfam00549 956149007659 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 956149007660 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 956149007661 E3 interaction surface; other site 956149007662 lipoyl attachment site [posttranslational modification]; other site 956149007663 e3 binding domain; Region: E3_binding; pfam02817 956149007664 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 956149007665 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 956149007666 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 956149007667 TPP-binding site [chemical binding]; other site 956149007668 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 956149007669 dimer interface [polypeptide binding]; other site 956149007670 PYR/PP interface [polypeptide binding]; other site 956149007671 TPP binding site [chemical binding]; other site 956149007672 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 956149007673 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 956149007674 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 956149007675 L-aspartate oxidase; Provisional; Region: PRK06175 956149007676 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 956149007677 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 956149007678 SdhC subunit interface [polypeptide binding]; other site 956149007679 proximal heme binding site [chemical binding]; other site 956149007680 cardiolipin binding site; other site 956149007681 Iron-sulfur protein interface; other site 956149007682 proximal quinone binding site [chemical binding]; other site 956149007683 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 956149007684 Iron-sulfur protein interface; other site 956149007685 proximal quinone binding site [chemical binding]; other site 956149007686 SdhD (CybS) interface [polypeptide binding]; other site 956149007687 proximal heme binding site [chemical binding]; other site 956149007688 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 956149007689 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 956149007690 dimer interface [polypeptide binding]; other site 956149007691 active site 956149007692 citrylCoA binding site [chemical binding]; other site 956149007693 NADH binding [chemical binding]; other site 956149007694 cationic pore residues; other site 956149007695 oxalacetate/citrate binding site [chemical binding]; other site 956149007696 coenzyme A binding site [chemical binding]; other site 956149007697 catalytic triad [active] 956149007698 endonuclease VIII; Provisional; Region: PRK10445 956149007699 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 956149007700 DNA binding site [nucleotide binding] 956149007701 catalytic residue [active] 956149007702 putative catalytic residues [active] 956149007703 H2TH interface [polypeptide binding]; other site 956149007704 intercalation triad [nucleotide binding]; other site 956149007705 substrate specificity determining residue; other site 956149007706 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 956149007707 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 956149007708 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 956149007709 Predicted membrane protein [Function unknown]; Region: COG3817 956149007710 Protein of unknown function (DUF979); Region: DUF979; pfam06166 956149007711 Protein of unknown function (DUF969); Region: DUF969; pfam06149 956149007712 MarR family; Region: MarR_2; cl17246 956149007713 LamB/YcsF family protein; Provisional; Region: PRK05406 956149007714 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 956149007715 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 956149007716 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 956149007717 Uncharacterized conserved protein [Function unknown]; Region: COG0327 956149007718 metal-binding protein; Provisional; Region: PRK10799 956149007719 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 956149007720 DNA photolyase; Region: DNA_photolyase; pfam00875 956149007721 Protein of unknown function (DUF523); Region: DUF523; pfam04463 956149007722 Uncharacterized conserved protein [Function unknown]; Region: COG3272 956149007723 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 956149007724 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 956149007725 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 956149007726 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 956149007727 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 956149007728 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 956149007729 sensor protein KdpD; Provisional; Region: PRK10490 956149007730 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 956149007731 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 956149007732 Ligand Binding Site [chemical binding]; other site 956149007733 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 956149007734 GAF domain; Region: GAF_3; pfam13492 956149007735 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 956149007736 dimer interface [polypeptide binding]; other site 956149007737 phosphorylation site [posttranslational modification] 956149007738 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 956149007739 ATP binding site [chemical binding]; other site 956149007740 Mg2+ binding site [ion binding]; other site 956149007741 G-X-G motif; other site 956149007742 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 956149007743 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 956149007744 active site 956149007745 phosphorylation site [posttranslational modification] 956149007746 intermolecular recognition site; other site 956149007747 dimerization interface [polypeptide binding]; other site 956149007748 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 956149007749 DNA binding site [nucleotide binding] 956149007750 Protein of unknown function (DUF2618); Region: DUF2618; pfam10940 956149007751 ornithine decarboxylase; Provisional; Region: PRK13578 956149007752 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 956149007753 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 956149007754 homodimer interface [polypeptide binding]; other site 956149007755 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149007756 catalytic residue [active] 956149007757 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 956149007758 putrescine transporter; Provisional; Region: potE; PRK10655 956149007759 phosphoglucomutase; Validated; Region: PRK07564 956149007760 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 956149007761 active site 956149007762 substrate binding site [chemical binding]; other site 956149007763 metal binding site [ion binding]; metal-binding site 956149007764 replication initiation regulator SeqA; Provisional; Region: PRK11187 956149007765 acyl-CoA esterase; Provisional; Region: PRK10673 956149007766 PGAP1-like protein; Region: PGAP1; pfam07819 956149007767 LexA regulated protein; Provisional; Region: PRK11675 956149007768 flavodoxin FldA; Validated; Region: PRK09267 956149007769 ferric uptake regulator; Provisional; Region: fur; PRK09462 956149007770 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 956149007771 metal binding site 2 [ion binding]; metal-binding site 956149007772 putative DNA binding helix; other site 956149007773 metal binding site 1 [ion binding]; metal-binding site 956149007774 dimer interface [polypeptide binding]; other site 956149007775 structural Zn2+ binding site [ion binding]; other site 956149007776 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 956149007777 Putative carbohydrate binding domain; Region: CHB_HEX; smart01081 956149007778 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 956149007779 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 956149007780 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a...; Region: GH20_Sm-chitobiase-like; cd06569 956149007781 active site 956149007782 C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847 956149007783 outer membrane porin, OprD family; Region: OprD; pfam03573 956149007784 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 956149007785 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 956149007786 active site 956149007787 HIGH motif; other site 956149007788 nucleotide binding site [chemical binding]; other site 956149007789 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 956149007790 KMSKS motif; other site 956149007791 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 956149007792 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 956149007793 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 956149007794 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 956149007795 active site turn [active] 956149007796 phosphorylation site [posttranslational modification] 956149007797 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 956149007798 HPr interaction site; other site 956149007799 glycerol kinase (GK) interaction site [polypeptide binding]; other site 956149007800 active site 956149007801 phosphorylation site [posttranslational modification] 956149007802 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 956149007803 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 956149007804 active site 956149007805 trimer interface [polypeptide binding]; other site 956149007806 allosteric site; other site 956149007807 active site lid [active] 956149007808 hexamer (dimer of trimers) interface [polypeptide binding]; other site 956149007809 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 956149007810 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 956149007811 active site 956149007812 dimer interface [polypeptide binding]; other site 956149007813 MarR family; Region: MarR; pfam01047 956149007814 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 956149007815 ROK family; Region: ROK; pfam00480 956149007816 UMP phosphatase; Provisional; Region: PRK10444 956149007817 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 956149007818 active site 956149007819 motif I; other site 956149007820 motif II; other site 956149007821 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 956149007822 asparagine synthetase B; Provisional; Region: asnB; PRK09431 956149007823 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 956149007824 active site 956149007825 dimer interface [polypeptide binding]; other site 956149007826 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 956149007827 Ligand Binding Site [chemical binding]; other site 956149007828 Molecular Tunnel; other site 956149007829 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 956149007830 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 956149007831 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 956149007832 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 956149007833 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 956149007834 FeS/SAM binding site; other site 956149007835 TRAM domain; Region: TRAM; pfam01938 956149007836 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 956149007837 PhoH-like protein; Region: PhoH; pfam02562 956149007838 metal-binding heat shock protein; Provisional; Region: PRK00016 956149007839 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 956149007840 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 956149007841 Transporter associated domain; Region: CorC_HlyC; smart01091 956149007842 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 956149007843 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 956149007844 putative active site [active] 956149007845 catalytic triad [active] 956149007846 putative dimer interface [polypeptide binding]; other site 956149007847 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 956149007848 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 956149007849 substrate binding pocket [chemical binding]; other site 956149007850 membrane-bound complex binding site; other site 956149007851 hinge residues; other site 956149007852 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 956149007853 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149007854 dimer interface [polypeptide binding]; other site 956149007855 conserved gate region; other site 956149007856 putative PBP binding loops; other site 956149007857 ABC-ATPase subunit interface; other site 956149007858 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 956149007859 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149007860 dimer interface [polypeptide binding]; other site 956149007861 conserved gate region; other site 956149007862 putative PBP binding loops; other site 956149007863 ABC-ATPase subunit interface; other site 956149007864 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 956149007865 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 956149007866 Walker A/P-loop; other site 956149007867 ATP binding site [chemical binding]; other site 956149007868 Q-loop/lid; other site 956149007869 ABC transporter signature motif; other site 956149007870 Walker B; other site 956149007871 D-loop; other site 956149007872 H-loop/switch region; other site 956149007873 hypothetical protein; Provisional; Region: PRK11032 956149007874 Predicted integral membrane metal-binding protein (DUF2296); Region: DUF2296; pfam10058 956149007875 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 956149007876 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 956149007877 HIGH motif; other site 956149007878 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 956149007879 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 956149007880 active site 956149007881 KMSKS motif; other site 956149007882 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 956149007883 tRNA binding surface [nucleotide binding]; other site 956149007884 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 956149007885 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 956149007886 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 956149007887 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 956149007888 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 956149007889 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 956149007890 active site 956149007891 (T/H)XGH motif; other site 956149007892 ribosome-associated protein; Provisional; Region: PRK11538 956149007893 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 956149007894 penicillin-binding protein 2; Provisional; Region: PRK10795 956149007895 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 956149007896 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 956149007897 cell wall shape-determining protein; Provisional; Region: PRK10794 956149007898 rare lipoprotein A; Provisional; Region: PRK10672 956149007899 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 956149007900 Sporulation related domain; Region: SPOR; pfam05036 956149007901 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 956149007902 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 956149007903 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 956149007904 hypothetical protein; Provisional; Region: PRK04998 956149007905 lipoate-protein ligase B; Provisional; Region: PRK14342 956149007906 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 956149007907 substrate binding pocket [chemical binding]; other site 956149007908 dimerization interface [polypeptide binding]; other site 956149007909 lipoyl synthase; Provisional; Region: PRK05481 956149007910 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 956149007911 FeS/SAM binding site; other site 956149007912 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 956149007913 Predicted amidohydrolase [General function prediction only]; Region: COG0388 956149007914 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 956149007915 putative active site [active] 956149007916 catalytic triad [active] 956149007917 putative dimer interface [polypeptide binding]; other site 956149007918 chromosome condensation membrane protein; Provisional; Region: PRK14196 956149007919 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 956149007920 DNA-binding site [nucleotide binding]; DNA binding site 956149007921 RNA-binding motif; other site 956149007922 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 956149007923 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 956149007924 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 956149007925 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 956149007926 B1 nucleotide binding pocket [chemical binding]; other site 956149007927 B2 nucleotide binding pocket [chemical binding]; other site 956149007928 CAS motifs; other site 956149007929 active site 956149007930 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 956149007931 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 956149007932 Ca binding site [ion binding]; other site 956149007933 active site 956149007934 catalytic site [active] 956149007935 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 956149007936 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 956149007937 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 956149007938 Ca binding site [ion binding]; other site 956149007939 active site 956149007940 catalytic site [active] 956149007941 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 956149007942 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 956149007943 Walker A/P-loop; other site 956149007944 ATP binding site [chemical binding]; other site 956149007945 Q-loop/lid; other site 956149007946 ABC transporter signature motif; other site 956149007947 Walker B; other site 956149007948 D-loop; other site 956149007949 H-loop/switch region; other site 956149007950 TOBE domain; Region: TOBE_2; pfam08402 956149007951 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 956149007952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149007953 dimer interface [polypeptide binding]; other site 956149007954 conserved gate region; other site 956149007955 putative PBP binding loops; other site 956149007956 ABC-ATPase subunit interface; other site 956149007957 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149007958 dimer interface [polypeptide binding]; other site 956149007959 conserved gate region; other site 956149007960 putative PBP binding loops; other site 956149007961 ABC-ATPase subunit interface; other site 956149007962 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 956149007963 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 956149007964 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 956149007965 fructuronate transporter; Provisional; Region: PRK10034; cl15264 956149007966 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 956149007967 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 956149007968 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 956149007969 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 956149007970 NAD binding site [chemical binding]; other site 956149007971 catalytic Zn binding site [ion binding]; other site 956149007972 structural Zn binding site [ion binding]; other site 956149007973 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 956149007974 Ligand Binding Site [chemical binding]; other site 956149007975 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 956149007976 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 956149007977 catalytic residue [active] 956149007978 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 956149007979 catalytic residues [active] 956149007980 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 956149007981 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 956149007982 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 956149007983 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 956149007984 dimer interface [polypeptide binding]; other site 956149007985 decamer (pentamer of dimers) interface [polypeptide binding]; other site 956149007986 catalytic triad [active] 956149007987 peroxidatic and resolving cysteines [active] 956149007988 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 956149007989 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149007990 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 956149007991 dimerization interface [polypeptide binding]; other site 956149007992 methionine aminotransferase; Validated; Region: PRK09082 956149007993 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 956149007994 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149007995 homodimer interface [polypeptide binding]; other site 956149007996 catalytic residue [active] 956149007997 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 956149007998 intersubunit interface [polypeptide binding]; other site 956149007999 active site 956149008000 Zn2+ binding site [ion binding]; other site 956149008001 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 956149008002 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 956149008003 Cupin domain; Region: Cupin_2; cl17218 956149008004 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 956149008005 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 956149008006 acyl-activating enzyme (AAE) consensus motif; other site 956149008007 AMP binding site [chemical binding]; other site 956149008008 MbtH-like protein; Region: MbtH; smart00923 956149008009 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 956149008010 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 956149008011 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 956149008012 outer membrane receptor FepA; Provisional; Region: PRK13524 956149008013 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 956149008014 N-terminal plug; other site 956149008015 ligand-binding site [chemical binding]; other site 956149008016 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 956149008017 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 956149008018 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 956149008019 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 956149008020 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 956149008021 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 956149008022 Nitrate and nitrite sensing; Region: NIT; pfam08376 956149008023 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 956149008024 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 956149008025 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 956149008026 dimer interface [polypeptide binding]; other site 956149008027 putative CheW interface [polypeptide binding]; other site 956149008028 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 956149008029 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 956149008030 ImpE protein; Region: ImpE; pfam07024 956149008031 PAAR motif; Region: PAAR_motif; pfam05488 956149008032 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 956149008033 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 956149008034 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 956149008035 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 956149008036 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 956149008037 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 956149008038 Fimbrial protein; Region: Fimbrial; pfam00419 956149008039 Glycosyltransferase (GlcNAc); Region: GlcNAc; pfam11397 956149008040 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 956149008041 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 956149008042 ligand binding site [chemical binding]; other site 956149008043 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 956149008044 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 956149008045 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 956149008046 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 956149008047 Coenzyme A binding pocket [chemical binding]; other site 956149008048 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 956149008049 active site residue [active] 956149008050 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 956149008051 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 956149008052 dimerization interface [polypeptide binding]; other site 956149008053 putative DNA binding site [nucleotide binding]; other site 956149008054 Transcriptional regulators [Transcription]; Region: MarR; COG1846 956149008055 putative Zn2+ binding site [ion binding]; other site 956149008056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149008057 Major Facilitator Superfamily; Region: MFS_1; pfam07690 956149008058 putative substrate translocation pore; other site 956149008059 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 956149008060 RES domain; Region: RES; cl02411 956149008061 Predicted transcriptional regulators [Transcription]; Region: COG1733 956149008062 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 956149008063 short chain dehydrogenase; Provisional; Region: PRK06500 956149008064 classical (c) SDRs; Region: SDR_c; cd05233 956149008065 NAD(P) binding site [chemical binding]; other site 956149008066 active site 956149008067 Helix-turn-helix domain; Region: HTH_18; pfam12833 956149008068 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 956149008069 SnoaL-like domain; Region: SnoaL_2; pfam12680 956149008070 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 956149008071 Helix-turn-helix domain; Region: HTH_18; pfam12833 956149008072 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 956149008073 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 956149008074 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 956149008075 active site 956149008076 Int/Topo IB signature motif; other site 956149008077 DNA binding site [nucleotide binding] 956149008078 Transposase; Region: HTH_Tnp_1; pfam01527 956149008079 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 956149008080 HTH-like domain; Region: HTH_21; pfam13276 956149008081 Integrase core domain; Region: rve; pfam00665 956149008082 Integrase core domain; Region: rve_3; pfam13683 956149008083 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 956149008084 LysE type translocator; Region: LysE; cl00565 956149008085 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 956149008086 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 956149008087 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 956149008088 active site 956149008089 Int/Topo IB signature motif; other site 956149008090 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 956149008091 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 956149008092 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 956149008093 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 956149008094 homodimer interface [polypeptide binding]; other site 956149008095 NADP binding site [chemical binding]; other site 956149008096 substrate binding site [chemical binding]; other site 956149008097 ribosome-associated protein; Provisional; Region: PRK11507 956149008098 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 956149008099 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 956149008100 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 956149008101 active site turn [active] 956149008102 phosphorylation site [posttranslational modification] 956149008103 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 956149008104 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 956149008105 DNA binding site [nucleotide binding] 956149008106 domain linker motif; other site 956149008107 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 956149008108 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 956149008109 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 956149008110 active site 956149008111 HIGH motif; other site 956149008112 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 956149008113 KMSKS motif; other site 956149008114 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 956149008115 tRNA binding surface [nucleotide binding]; other site 956149008116 anticodon binding site; other site 956149008117 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 956149008118 substrate binding site [chemical binding]; other site 956149008119 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 956149008120 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 956149008121 putative active site [active] 956149008122 putative metal binding site [ion binding]; other site 956149008123 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 956149008124 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 956149008125 ATP-grasp domain; Region: ATP-grasp; pfam02222 956149008126 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 956149008127 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 956149008128 homodimer interface [polypeptide binding]; other site 956149008129 substrate-cofactor binding pocket; other site 956149008130 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149008131 catalytic residue [active] 956149008132 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 956149008133 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 956149008134 dimer interface [polypeptide binding]; other site 956149008135 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149008136 catalytic residue [active] 956149008137 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 956149008138 FOG: CBS domain [General function prediction only]; Region: COG0517 956149008139 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 956149008140 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 956149008141 active site residue [active] 956149008142 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 956149008143 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 956149008144 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 956149008145 Walker A/P-loop; other site 956149008146 ATP binding site [chemical binding]; other site 956149008147 Q-loop/lid; other site 956149008148 ABC transporter signature motif; other site 956149008149 Walker B; other site 956149008150 D-loop; other site 956149008151 H-loop/switch region; other site 956149008152 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 956149008153 active site 956149008154 catalytic triad [active] 956149008155 oxyanion hole [active] 956149008156 switch loop; other site 956149008157 oxidoreductase; Provisional; Region: PRK08017 956149008158 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 956149008159 NADP binding site [chemical binding]; other site 956149008160 active site 956149008161 steroid binding site; other site 956149008162 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 956149008163 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 956149008164 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 956149008165 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 956149008166 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 956149008167 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 956149008168 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 956149008169 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 956149008170 DNA binding residues [nucleotide binding] 956149008171 dimer interface [polypeptide binding]; other site 956149008172 copper binding site [ion binding]; other site 956149008173 copper exporting ATPase; Provisional; Region: copA; PRK10671 956149008174 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 956149008175 metal-binding site [ion binding] 956149008176 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 956149008177 metal-binding site [ion binding] 956149008178 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 956149008179 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 956149008180 motif I; other site 956149008181 motif II; other site 956149008182 TraB family; Region: TraB; cl12050 956149008183 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 956149008184 putative deacylase active site [active] 956149008185 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 956149008186 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 956149008187 active site 956149008188 metal binding site [ion binding]; metal-binding site 956149008189 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 956149008190 putative cation:proton antiport protein; Provisional; Region: PRK10669 956149008191 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 956149008192 TrkA-N domain; Region: TrkA_N; pfam02254 956149008193 inosine/guanosine kinase; Provisional; Region: PRK15074 956149008194 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 956149008195 ferrochelatase; Reviewed; Region: hemH; PRK00035 956149008196 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 956149008197 C-terminal domain interface [polypeptide binding]; other site 956149008198 active site 956149008199 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 956149008200 active site 956149008201 N-terminal domain interface [polypeptide binding]; other site 956149008202 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 956149008203 fructuronate transporter; Provisional; Region: PRK10034; cl15264 956149008204 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 956149008205 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 956149008206 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 956149008207 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 956149008208 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 956149008209 adenylate kinase; Reviewed; Region: adk; PRK00279 956149008210 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 956149008211 AMP-binding site [chemical binding]; other site 956149008212 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 956149008213 heat shock protein 90; Provisional; Region: PRK05218 956149008214 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 956149008215 ATP binding site [chemical binding]; other site 956149008216 Mg2+ binding site [ion binding]; other site 956149008217 G-X-G motif; other site 956149008218 recombination protein RecR; Reviewed; Region: recR; PRK00076 956149008219 RecR protein; Region: RecR; pfam02132 956149008220 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 956149008221 putative active site [active] 956149008222 putative metal-binding site [ion binding]; other site 956149008223 tetramer interface [polypeptide binding]; other site 956149008224 putative major fimbrial protein SthE; Provisional; Region: PRK15292 956149008225 Fimbrial protein; Region: Fimbrial; pfam00419 956149008226 putative fimbrial protein SthD; Provisional; Region: PRK15293 956149008227 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 956149008228 PapC N-terminal domain; Region: PapC_N; pfam13954 956149008229 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 956149008230 PapC C-terminal domain; Region: PapC_C; pfam13953 956149008231 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 956149008232 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 956149008233 putative fimbrial protein SthA; Provisional; Region: PRK15296 956149008234 hypothetical protein; Validated; Region: PRK00153 956149008235 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 956149008236 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 956149008237 Walker A motif; other site 956149008238 ATP binding site [chemical binding]; other site 956149008239 Walker B motif; other site 956149008240 arginine finger; other site 956149008241 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 956149008242 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 956149008243 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 956149008244 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 956149008245 active site 956149008246 hypothetical protein; Provisional; Region: PRK10527 956149008247 Primosomal replication protein priB and priC; Region: priB_priC; pfam07445 956149008248 hypothetical protein; Provisional; Region: PRK11038 956149008249 hypothetical protein; Provisional; Region: PRK11281 956149008250 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 956149008251 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 956149008252 Mechanosensitive ion channel; Region: MS_channel; pfam00924 956149008253 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 956149008254 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 956149008255 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 956149008256 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 956149008257 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 956149008258 HlyD family secretion protein; Region: HlyD_3; pfam13437 956149008259 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 956149008260 Protein export membrane protein; Region: SecD_SecF; cl14618 956149008261 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 956149008262 Hha toxicity attenuator; Provisional; Region: PRK10667 956149008263 gene expression modulator; Provisional; Region: PRK10945 956149008264 maltose O-acetyltransferase; Provisional; Region: PRK10092 956149008265 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 956149008266 active site 956149008267 substrate binding site [chemical binding]; other site 956149008268 trimer interface [polypeptide binding]; other site 956149008269 CoA binding site [chemical binding]; other site 956149008270 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 956149008271 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 956149008272 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 956149008273 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 956149008274 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 956149008275 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 956149008276 dimer interface [polypeptide binding]; other site 956149008277 putative CheW interface [polypeptide binding]; other site 956149008278 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 956149008279 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 956149008280 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 956149008281 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 956149008282 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 956149008283 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 956149008284 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 956149008285 Walker A/P-loop; other site 956149008286 ATP binding site [chemical binding]; other site 956149008287 Q-loop/lid; other site 956149008288 ABC transporter signature motif; other site 956149008289 Walker B; other site 956149008290 D-loop; other site 956149008291 H-loop/switch region; other site 956149008292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149008293 dimer interface [polypeptide binding]; other site 956149008294 conserved gate region; other site 956149008295 ABC-ATPase subunit interface; other site 956149008296 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 956149008297 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 956149008298 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 956149008299 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 956149008300 Coenzyme A binding pocket [chemical binding]; other site 956149008301 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 956149008302 Predicted membrane protein [Function unknown]; Region: COG2364 956149008303 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 956149008304 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 956149008305 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 956149008306 DNA-binding site [nucleotide binding]; DNA binding site 956149008307 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 956149008308 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149008309 homodimer interface [polypeptide binding]; other site 956149008310 catalytic residue [active] 956149008311 Bacterial SH3 domain; Region: SH3_3; cl17532 956149008312 Protein of unknown function (DUF3380); Region: DUF3380; pfam11860 956149008313 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 956149008314 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 956149008315 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 956149008316 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 956149008317 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 956149008318 CT1975-like protein; Region: Cas_CT1975; pfam09344 956149008319 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 956149008320 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 956149008321 potential frameshift: common BLAST hit: gi|389841924|ref|YP_006344008.1| CRISPR-associated helicase Cas3 956149008322 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 956149008323 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 956149008324 DNA binding site [nucleotide binding] 956149008325 active site 956149008326 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 956149008327 acyl-CoA thioesterase II; Provisional; Region: PRK10526 956149008328 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 956149008329 active site 956149008330 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 956149008331 catalytic triad [active] 956149008332 dimer interface [polypeptide binding]; other site 956149008333 ammonium transporter; Provisional; Region: PRK10666 956149008334 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 956149008335 Nitrogen regulatory protein P-II; Region: P-II; smart00938 956149008336 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 956149008337 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 956149008338 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 956149008339 Walker A/P-loop; other site 956149008340 ATP binding site [chemical binding]; other site 956149008341 Q-loop/lid; other site 956149008342 ABC transporter signature motif; other site 956149008343 Walker B; other site 956149008344 D-loop; other site 956149008345 H-loop/switch region; other site 956149008346 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 956149008347 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 956149008348 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 956149008349 Walker A/P-loop; other site 956149008350 ATP binding site [chemical binding]; other site 956149008351 Q-loop/lid; other site 956149008352 ABC transporter signature motif; other site 956149008353 Walker B; other site 956149008354 D-loop; other site 956149008355 H-loop/switch region; other site 956149008356 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 956149008357 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 956149008358 putative DNA binding site [nucleotide binding]; other site 956149008359 putative Zn2+ binding site [ion binding]; other site 956149008360 AsnC family; Region: AsnC_trans_reg; pfam01037 956149008361 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 956149008362 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 956149008363 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 956149008364 catalytic residue [active] 956149008365 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 956149008366 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 956149008367 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 956149008368 active site 956149008369 motif I; other site 956149008370 motif II; other site 956149008371 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 956149008372 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 956149008373 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 956149008374 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 956149008375 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 956149008376 Ligand Binding Site [chemical binding]; other site 956149008377 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 956149008378 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 956149008379 active site 956149008380 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 956149008381 periplasmic folding chaperone; Provisional; Region: PRK10788 956149008382 SurA N-terminal domain; Region: SurA_N_3; cl07813 956149008383 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 956149008384 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 956149008385 IHF dimer interface [polypeptide binding]; other site 956149008386 IHF - DNA interface [nucleotide binding]; other site 956149008387 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 956149008388 Found in ATP-dependent protease La (LON); Region: LON; smart00464 956149008389 Found in ATP-dependent protease La (LON); Region: LON; smart00464 956149008390 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 956149008391 Walker A motif; other site 956149008392 ATP binding site [chemical binding]; other site 956149008393 Walker B motif; other site 956149008394 arginine finger; other site 956149008395 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 956149008396 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 956149008397 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 956149008398 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 956149008399 Walker A motif; other site 956149008400 ATP binding site [chemical binding]; other site 956149008401 Walker B motif; other site 956149008402 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 956149008403 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 956149008404 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 956149008405 oligomer interface [polypeptide binding]; other site 956149008406 active site residues [active] 956149008407 trigger factor; Provisional; Region: tig; PRK01490 956149008408 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 956149008409 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 956149008410 transcriptional regulator BolA; Provisional; Region: PRK11628 956149008411 hypothetical protein; Provisional; Region: PRK11627 956149008412 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 956149008413 muropeptide transporter; Reviewed; Region: ampG; PRK11902 956149008414 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149008415 putative substrate translocation pore; other site 956149008416 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 956149008417 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 956149008418 nucleotide binding site [chemical binding]; other site 956149008419 putative NEF/HSP70 interaction site [polypeptide binding]; other site 956149008420 SBD interface [polypeptide binding]; other site 956149008421 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 956149008422 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 956149008423 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 956149008424 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 956149008425 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 956149008426 D-pathway; other site 956149008427 Putative ubiquinol binding site [chemical binding]; other site 956149008428 Low-spin heme (heme b) binding site [chemical binding]; other site 956149008429 Putative water exit pathway; other site 956149008430 Binuclear center (heme o3/CuB) [ion binding]; other site 956149008431 K-pathway; other site 956149008432 Putative proton exit pathway; other site 956149008433 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 956149008434 Subunit I/III interface [polypeptide binding]; other site 956149008435 Subunit III/IV interface [polypeptide binding]; other site 956149008436 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 956149008437 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 956149008438 UbiA prenyltransferase family; Region: UbiA; pfam01040 956149008439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149008440 Major Facilitator Superfamily; Region: MFS_1; pfam07690 956149008441 putative substrate translocation pore; other site 956149008442 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 956149008443 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 956149008444 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 956149008445 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 956149008446 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 956149008447 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 956149008448 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 956149008449 conserved cys residue [active] 956149008450 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 956149008451 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 956149008452 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 956149008453 Ligand Binding Site [chemical binding]; other site 956149008454 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 956149008455 active site residue [active] 956149008456 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 956149008457 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 956149008458 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 956149008459 substrate binding pocket [chemical binding]; other site 956149008460 chain length determination region; other site 956149008461 substrate-Mg2+ binding site; other site 956149008462 catalytic residues [active] 956149008463 aspartate-rich region 1; other site 956149008464 active site lid residues [active] 956149008465 aspartate-rich region 2; other site 956149008466 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 956149008467 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 956149008468 TPP-binding site; other site 956149008469 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 956149008470 PYR/PP interface [polypeptide binding]; other site 956149008471 dimer interface [polypeptide binding]; other site 956149008472 TPP binding site [chemical binding]; other site 956149008473 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 956149008474 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 956149008475 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 956149008476 active site 956149008477 catalytic tetrad [active] 956149008478 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 956149008479 tetramer interfaces [polypeptide binding]; other site 956149008480 binuclear metal-binding site [ion binding]; other site 956149008481 thiamine monophosphate kinase; Provisional; Region: PRK05731 956149008482 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 956149008483 ATP binding site [chemical binding]; other site 956149008484 dimerization interface [polypeptide binding]; other site 956149008485 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 956149008486 putative RNA binding site [nucleotide binding]; other site 956149008487 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 956149008488 homopentamer interface [polypeptide binding]; other site 956149008489 active site 956149008490 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 956149008491 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 956149008492 catalytic motif [active] 956149008493 Zn binding site [ion binding]; other site 956149008494 RibD C-terminal domain; Region: RibD_C; cl17279 956149008495 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 956149008496 ATP cone domain; Region: ATP-cone; pfam03477 956149008497 hypothetical protein; Provisional; Region: PRK11530 956149008498 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 956149008499 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 956149008500 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 956149008501 Protein export membrane protein; Region: SecD_SecF; pfam02355 956149008502 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 956149008503 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 956149008504 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 956149008505 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 956149008506 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 956149008507 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 956149008508 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 956149008509 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 956149008510 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 956149008511 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 956149008512 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 956149008513 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 956149008514 maltodextrin glucosidase; Provisional; Region: PRK10785 956149008515 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 956149008516 homodimer interface [polypeptide binding]; other site 956149008517 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 956149008518 active site 956149008519 homodimer interface [polypeptide binding]; other site 956149008520 catalytic site [active] 956149008521 putative proline-specific permease; Provisional; Region: proY; PRK10580 956149008522 Spore germination protein; Region: Spore_permease; cl17796 956149008523 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 956149008524 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 956149008525 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 956149008526 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 956149008527 putative active site [active] 956149008528 heme pocket [chemical binding]; other site 956149008529 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 956149008530 dimer interface [polypeptide binding]; other site 956149008531 phosphorylation site [posttranslational modification] 956149008532 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 956149008533 ATP binding site [chemical binding]; other site 956149008534 Mg2+ binding site [ion binding]; other site 956149008535 G-X-G motif; other site 956149008536 transcriptional regulator PhoB; Provisional; Region: PRK10161 956149008537 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 956149008538 active site 956149008539 phosphorylation site [posttranslational modification] 956149008540 intermolecular recognition site; other site 956149008541 dimerization interface [polypeptide binding]; other site 956149008542 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 956149008543 DNA binding site [nucleotide binding] 956149008544 exonuclease subunit SbcD; Provisional; Region: PRK10966 956149008545 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 956149008546 active site 956149008547 metal binding site [ion binding]; metal-binding site 956149008548 DNA binding site [nucleotide binding] 956149008549 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 956149008550 exonuclease subunit SbcC; Provisional; Region: PRK10246 956149008551 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 956149008552 Walker A/P-loop; other site 956149008553 ATP binding site [chemical binding]; other site 956149008554 Q-loop/lid; other site 956149008555 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 956149008556 ABC transporter signature motif; other site 956149008557 Walker B; other site 956149008558 D-loop; other site 956149008559 H-loop/switch region; other site 956149008560 fructokinase; Reviewed; Region: PRK09557 956149008561 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 956149008562 nucleotide binding site [chemical binding]; other site 956149008563 recombination associated protein; Reviewed; Region: rdgC; PRK00321 956149008564 hypothetical protein; Provisional; Region: PRK10579 956149008565 hypothetical protein; Provisional; Region: PRK10481 956149008566 hypothetical protein; Provisional; Region: PRK10380 956149008567 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 956149008568 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 956149008569 ADP binding site [chemical binding]; other site 956149008570 magnesium binding site [ion binding]; other site 956149008571 putative shikimate binding site; other site 956149008572 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 956149008573 hypothetical protein; Validated; Region: PRK00124 956149008574 Predicted membrane protein [Function unknown]; Region: COG2323 956149008575 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 956149008576 pyrroline-5-carboxylate reductase; Region: PLN02688 956149008577 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 956149008578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149008579 putative substrate translocation pore; other site 956149008580 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149008581 anti-RssB factor; Provisional; Region: PRK10244 956149008582 drug efflux system protein MdtG; Provisional; Region: PRK09874 956149008583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149008584 putative substrate translocation pore; other site 956149008585 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 956149008586 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 956149008587 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 956149008588 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 956149008589 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 956149008590 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 956149008591 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 956149008592 microcin B17 transporter; Reviewed; Region: PRK11098 956149008593 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 956149008594 Isochorismatase family; Region: Isochorismatase; pfam00857 956149008595 catalytic triad [active] 956149008596 conserved cis-peptide bond; other site 956149008597 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 956149008598 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 956149008599 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 956149008600 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 956149008601 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 956149008602 Autotransporter beta-domain; Region: Autotransporter; pfam03797 956149008603 Competence-damaged protein; Region: CinA; pfam02464 956149008604 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 956149008605 dimer interface [polypeptide binding]; other site 956149008606 active site 956149008607 Schiff base residues; other site 956149008608 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 956149008609 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 956149008610 putative acyl-acceptor binding pocket; other site 956149008611 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 956149008612 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 956149008613 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 956149008614 active site 956149008615 iron coordination sites [ion binding]; other site 956149008616 substrate binding pocket [chemical binding]; other site 956149008617 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 956149008618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149008619 dimer interface [polypeptide binding]; other site 956149008620 conserved gate region; other site 956149008621 putative PBP binding loops; other site 956149008622 ABC-ATPase subunit interface; other site 956149008623 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 956149008624 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 956149008625 Walker A/P-loop; other site 956149008626 ATP binding site [chemical binding]; other site 956149008627 Q-loop/lid; other site 956149008628 ABC transporter signature motif; other site 956149008629 Walker B; other site 956149008630 D-loop; other site 956149008631 H-loop/switch region; other site 956149008632 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 956149008633 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 956149008634 substrate binding pocket [chemical binding]; other site 956149008635 membrane-bound complex binding site; other site 956149008636 hinge residues; other site 956149008637 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 956149008638 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 956149008639 S-methylmethionine transporter; Provisional; Region: PRK11387 956149008640 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 956149008641 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 956149008642 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 956149008643 4Fe-4S binding domain; Region: Fer4; pfam00037 956149008644 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 956149008645 [4Fe-4S] binding site [ion binding]; other site 956149008646 molybdopterin cofactor binding site; other site 956149008647 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 956149008648 molybdopterin cofactor binding site; other site 956149008649 Uncharacterized conserved protein [Function unknown]; Region: COG2427 956149008650 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 956149008651 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 956149008652 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 956149008653 Hok/gef family; Region: HOK_GEF; pfam01848 956149008654 Predicted ATPase [General function prediction only]; Region: COG1485 956149008655 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 956149008656 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 956149008657 putative acyl-acceptor binding pocket; other site 956149008658 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 956149008659 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 956149008660 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 956149008661 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 956149008662 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 956149008663 dimer interface [polypeptide binding]; other site 956149008664 ADP-ribose binding site [chemical binding]; other site 956149008665 active site 956149008666 nudix motif; other site 956149008667 metal binding site [ion binding]; metal-binding site 956149008668 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 956149008669 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 956149008670 EAL domain; Region: EAL; pfam00563 956149008671 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 956149008672 active site clefts [active] 956149008673 zinc binding site [ion binding]; other site 956149008674 dimer interface [polypeptide binding]; other site 956149008675 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 956149008676 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 956149008677 Sulfate transporter family; Region: Sulfate_transp; pfam00916 956149008678 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 956149008679 Domain of unknown function DUF20; Region: UPF0118; pfam01594 956149008680 Transcriptional regulator [Transcription]; Region: LysR; COG0583 956149008681 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149008682 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 956149008683 putative effector binding pocket; other site 956149008684 dimerization interface [polypeptide binding]; other site 956149008685 Protein of unknown function, DUF606; Region: DUF606; pfam04657 956149008686 Protein of unknown function, DUF606; Region: DUF606; pfam04657 956149008687 Transcriptional regulator [Transcription]; Region: LysR; COG0583 956149008688 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149008689 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 956149008690 dimerization interface [polypeptide binding]; other site 956149008691 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; pfam05870 956149008692 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 956149008693 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 956149008694 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 956149008695 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 956149008696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149008697 dimer interface [polypeptide binding]; other site 956149008698 conserved gate region; other site 956149008699 putative PBP binding loops; other site 956149008700 ABC-ATPase subunit interface; other site 956149008701 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 956149008702 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 956149008703 Walker A/P-loop; other site 956149008704 ATP binding site [chemical binding]; other site 956149008705 Q-loop/lid; other site 956149008706 ABC transporter signature motif; other site 956149008707 Walker B; other site 956149008708 D-loop; other site 956149008709 H-loop/switch region; other site 956149008710 NIL domain; Region: NIL; pfam09383 956149008711 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 956149008712 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 956149008713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149008714 putative substrate translocation pore; other site 956149008715 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 956149008716 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 956149008717 Metal-binding active site; metal-binding site 956149008718 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 956149008719 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 956149008720 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 956149008721 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 956149008722 potential frameshift: common BLAST hit: gi|389842057|ref|YP_006344141.1| 3D-(3,5/4)-trihydroxycyclohexane-1,2-dionehydrolase 956149008723 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 956149008724 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 956149008725 substrate binding site [chemical binding]; other site 956149008726 ATP binding site [chemical binding]; other site 956149008727 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 956149008728 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 956149008729 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 956149008730 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 956149008731 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 956149008732 putative active site [active] 956149008733 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 956149008734 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 956149008735 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 956149008736 tetrameric interface [polypeptide binding]; other site 956149008737 NAD binding site [chemical binding]; other site 956149008738 catalytic residues [active] 956149008739 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 956149008740 malate dehydrogenase; Provisional; Region: PRK13529 956149008741 Malic enzyme, N-terminal domain; Region: malic; pfam00390 956149008742 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 956149008743 NAD(P) binding site [chemical binding]; other site 956149008744 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 956149008745 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149008746 putative substrate translocation pore; other site 956149008747 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 956149008748 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 956149008749 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 956149008750 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 956149008751 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 956149008752 lac repressor; Reviewed; Region: lacI; PRK09526 956149008753 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 956149008754 DNA binding site [nucleotide binding] 956149008755 domain linker motif; other site 956149008756 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 956149008757 ligand binding site [chemical binding]; other site 956149008758 dimerization interface (open form) [polypeptide binding]; other site 956149008759 dimerization interface (closed form) [polypeptide binding]; other site 956149008760 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 956149008761 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 956149008762 NAD(P) binding site [chemical binding]; other site 956149008763 active site 956149008764 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 956149008765 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 956149008766 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 956149008767 homotrimer interaction site [polypeptide binding]; other site 956149008768 putative active site [active] 956149008769 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 956149008770 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 956149008771 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 956149008772 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 956149008773 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 956149008774 conserved cys residue [active] 956149008775 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 956149008776 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 956149008777 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 956149008778 active site 956149008779 dimer interface [polypeptide binding]; other site 956149008780 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 956149008781 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 956149008782 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 956149008783 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 956149008784 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 956149008785 pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079 956149008786 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 956149008787 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 956149008788 FeS/SAM binding site; other site 956149008789 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 956149008790 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 956149008791 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 956149008792 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 956149008793 peptide binding site [polypeptide binding]; other site 956149008794 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 956149008795 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 956149008796 metal binding site [ion binding]; metal-binding site 956149008797 dimer interface [polypeptide binding]; other site 956149008798 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 956149008799 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 956149008800 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 956149008801 HicB family; Region: HicB; pfam05534 956149008802 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 956149008803 erythrose-4-phosphate dehydrogenase; Region: E4PD_g-proteo; TIGR01532 956149008804 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 956149008805 Preprotein binding site; other site 956149008806 SecA binding site; other site 956149008807 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 956149008808 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 956149008809 putative catalytic cysteine [active] 956149008810 gamma-glutamyl kinase; Provisional; Region: PRK05429 956149008811 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 956149008812 nucleotide binding site [chemical binding]; other site 956149008813 homotetrameric interface [polypeptide binding]; other site 956149008814 putative phosphate binding site [ion binding]; other site 956149008815 putative allosteric binding site; other site 956149008816 PUA domain; Region: PUA; pfam01472 956149008817 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 956149008818 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 956149008819 trimer interface [polypeptide binding]; other site 956149008820 eyelet of channel; other site 956149008821 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 956149008822 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 956149008823 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 956149008824 active site 956149008825 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 956149008826 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 956149008827 metal binding site [ion binding]; metal-binding site 956149008828 dimer interface [polypeptide binding]; other site 956149008829 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 956149008830 active site 956149008831 DNA polymerase IV; Validated; Region: PRK02406 956149008832 DNA binding site [nucleotide binding] 956149008833 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 956149008834 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 956149008835 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 956149008836 putative active site [active] 956149008837 putative dimer interface [polypeptide binding]; other site 956149008838 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 956149008839 dimer interface [polypeptide binding]; other site 956149008840 active site 956149008841 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 956149008842 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 956149008843 active site 956149008844 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 956149008845 C-N hydrolase family amidase; Provisional; Region: PRK10438 956149008846 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 956149008847 putative active site [active] 956149008848 catalytic triad [active] 956149008849 dimer interface [polypeptide binding]; other site 956149008850 multimer interface [polypeptide binding]; other site 956149008851 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cl07688 956149008852 mannosyl binding site [chemical binding]; other site 956149008853 Fimbrial protein; Region: Fimbrial; pfam00419 956149008854 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 956149008855 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 956149008856 active site 956149008857 catalytic site [active] 956149008858 substrate binding site [chemical binding]; other site 956149008859 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 956149008860 RNA/DNA hybrid binding site [nucleotide binding]; other site 956149008861 active site 956149008862 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 956149008863 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 956149008864 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 956149008865 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 956149008866 N-acetyl-D-glucosamine binding site [chemical binding]; other site 956149008867 catalytic residue [active] 956149008868 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 956149008869 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 956149008870 Methyltransferase domain; Region: Methyltransf_31; pfam13847 956149008871 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 956149008872 S-adenosylmethionine binding site [chemical binding]; other site 956149008873 Flavivirus glycoprotein, central and dimerisation domains; Region: Flavi_glycoprot; pfam00869 956149008874 hypothetical protein; Provisional; Region: PRK05421 956149008875 putative catalytic site [active] 956149008876 putative phosphate binding site [ion binding]; other site 956149008877 putative metal binding site [ion binding]; other site 956149008878 Transcriptional regulator [Transcription]; Region: LysR; COG0583 956149008879 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149008880 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 956149008881 putative effector binding pocket; other site 956149008882 dimerization interface [polypeptide binding]; other site 956149008883 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 956149008884 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 956149008885 active site 956149008886 catalytic tetrad [active] 956149008887 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 956149008888 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 956149008889 active site 956149008890 motif I; other site 956149008891 motif II; other site 956149008892 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 956149008893 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 956149008894 Walker A/P-loop; other site 956149008895 ATP binding site [chemical binding]; other site 956149008896 Q-loop/lid; other site 956149008897 ABC transporter signature motif; other site 956149008898 Walker B; other site 956149008899 D-loop; other site 956149008900 H-loop/switch region; other site 956149008901 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 956149008902 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149008903 dimer interface [polypeptide binding]; other site 956149008904 conserved gate region; other site 956149008905 ABC-ATPase subunit interface; other site 956149008906 potential frameshift: common BLAST hit: gi|156935284|ref|YP_001439200.1| DL-methionine transporter substrate-binding subunit 956149008907 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 956149008908 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 956149008909 homodimer interaction site [polypeptide binding]; other site 956149008910 cofactor binding site; other site 956149008911 prolyl-tRNA synthetase; Provisional; Region: PRK09194 956149008912 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 956149008913 dimer interface [polypeptide binding]; other site 956149008914 motif 1; other site 956149008915 active site 956149008916 motif 2; other site 956149008917 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 956149008918 putative deacylase active site [active] 956149008919 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 956149008920 active site 956149008921 motif 3; other site 956149008922 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 956149008923 anticodon binding site; other site 956149008924 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 956149008925 NlpE N-terminal domain; Region: NlpE; pfam04170 956149008926 hypothetical protein; Provisional; Region: PRK09256 956149008927 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 956149008928 YaeQ protein; Region: YaeQ; pfam07152 956149008929 hypothetical protein; Provisional; Region: PRK04964 956149008930 Rho-binding antiterminator; Provisional; Region: PRK11625 956149008931 Cytochrome c553 [Energy production and conversion]; Region: COG2863 956149008932 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 956149008933 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 956149008934 Ligand Binding Site [chemical binding]; other site 956149008935 TilS substrate binding domain; Region: TilS; pfam09179 956149008936 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 956149008937 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 956149008938 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 956149008939 putative metal binding site [ion binding]; other site 956149008940 lysine decarboxylase LdcC; Provisional; Region: PRK15399 956149008941 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 956149008942 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 956149008943 homodimer interface [polypeptide binding]; other site 956149008944 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149008945 catalytic residue [active] 956149008946 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 956149008947 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 956149008948 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 956149008949 putative sugar binding site [chemical binding]; other site 956149008950 catalytic residues [active] 956149008951 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 956149008952 aromatic chitin/cellulose binding site residues [chemical binding]; other site 956149008953 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 956149008954 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 956149008955 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 956149008956 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 956149008957 putative active site [active] 956149008958 putative PHP Thumb interface [polypeptide binding]; other site 956149008959 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 956149008960 generic binding surface II; other site 956149008961 generic binding surface I; other site 956149008962 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 956149008963 RNA/DNA hybrid binding site [nucleotide binding]; other site 956149008964 active site 956149008965 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 956149008966 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 956149008967 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 956149008968 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 956149008969 active site 956149008970 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 956149008971 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 956149008972 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 956149008973 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 956149008974 trimer interface [polypeptide binding]; other site 956149008975 active site 956149008976 UDP-GlcNAc binding site [chemical binding]; other site 956149008977 lipid binding site [chemical binding]; lipid-binding site 956149008978 periplasmic chaperone; Provisional; Region: PRK10780 956149008979 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 956149008980 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 956149008981 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 956149008982 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 956149008983 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 956149008984 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 956149008985 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 956149008986 Surface antigen; Region: Bac_surface_Ag; pfam01103 956149008987 zinc metallopeptidase RseP; Provisional; Region: PRK10779 956149008988 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 956149008989 active site 956149008990 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 956149008991 protein binding site [polypeptide binding]; other site 956149008992 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 956149008993 protein binding site [polypeptide binding]; other site 956149008994 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 956149008995 putative substrate binding region [chemical binding]; other site 956149008996 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 956149008997 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 956149008998 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 956149008999 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 956149009000 catalytic residue [active] 956149009001 putative FPP diphosphate binding site; other site 956149009002 putative FPP binding hydrophobic cleft; other site 956149009003 dimer interface [polypeptide binding]; other site 956149009004 putative IPP diphosphate binding site; other site 956149009005 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 956149009006 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 956149009007 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 956149009008 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 956149009009 ribosome recycling factor; Reviewed; Region: frr; PRK00083 956149009010 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 956149009011 hinge region; other site 956149009012 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 956149009013 putative nucleotide binding site [chemical binding]; other site 956149009014 uridine monophosphate binding site [chemical binding]; other site 956149009015 homohexameric interface [polypeptide binding]; other site 956149009016 elongation factor Ts; Provisional; Region: tsf; PRK09377 956149009017 UBA/TS-N domain; Region: UBA; pfam00627 956149009018 Elongation factor TS; Region: EF_TS; pfam00889 956149009019 Elongation factor TS; Region: EF_TS; pfam00889 956149009020 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 956149009021 rRNA interaction site [nucleotide binding]; other site 956149009022 S8 interaction site; other site 956149009023 putative laminin-1 binding site; other site 956149009024 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 956149009025 active site 956149009026 PII uridylyl-transferase; Provisional; Region: PRK05007 956149009027 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 956149009028 metal binding triad; other site 956149009029 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 956149009030 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 956149009031 Zn2+ binding site [ion binding]; other site 956149009032 Mg2+ binding site [ion binding]; other site 956149009033 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 956149009034 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 956149009035 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 956149009036 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 956149009037 trimer interface [polypeptide binding]; other site 956149009038 active site 956149009039 substrate binding site [chemical binding]; other site 956149009040 CoA binding site [chemical binding]; other site 956149009041 hypothetical protein; Provisional; Region: PRK13677 956149009042 serine endoprotease; Provisional; Region: PRK10942 956149009043 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 956149009044 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 956149009045 protein binding site [polypeptide binding]; other site 956149009046 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 956149009047 protein binding site [polypeptide binding]; other site 956149009048 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 956149009049 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 956149009050 Zn2+ binding site [ion binding]; other site 956149009051 Mg2+ binding site [ion binding]; other site 956149009052 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 956149009053 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 956149009054 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 956149009055 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 956149009056 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 956149009057 cobalamin binding residues [chemical binding]; other site 956149009058 putative BtuC binding residues; other site 956149009059 dimer interface [polypeptide binding]; other site 956149009060 hypothetical protein; Provisional; Region: PRK10578 956149009061 UPF0126 domain; Region: UPF0126; pfam03458 956149009062 UPF0126 domain; Region: UPF0126; pfam03458 956149009063 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 956149009064 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 956149009065 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 956149009066 Cl- selectivity filter; other site 956149009067 Cl- binding residues [ion binding]; other site 956149009068 pore gating glutamate residue; other site 956149009069 dimer interface [polypeptide binding]; other site 956149009070 H+/Cl- coupling transport residue; other site 956149009071 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 956149009072 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 956149009073 inhibitor-cofactor binding pocket; inhibition site 956149009074 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149009075 catalytic residue [active] 956149009076 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 956149009077 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 956149009078 ABC-ATPase subunit interface; other site 956149009079 dimer interface [polypeptide binding]; other site 956149009080 putative PBP binding regions; other site 956149009081 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 956149009082 ABC-ATPase subunit interface; other site 956149009083 dimer interface [polypeptide binding]; other site 956149009084 putative PBP binding regions; other site 956149009085 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 956149009086 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 956149009087 siderophore binding site; other site 956149009088 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 956149009089 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 956149009090 Walker A/P-loop; other site 956149009091 ATP binding site [chemical binding]; other site 956149009092 Q-loop/lid; other site 956149009093 ABC transporter signature motif; other site 956149009094 Walker B; other site 956149009095 D-loop; other site 956149009096 H-loop/switch region; other site 956149009097 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 956149009098 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 956149009099 N-terminal plug; other site 956149009100 ligand-binding site [chemical binding]; other site 956149009101 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 956149009102 Transglycosylase; Region: Transgly; pfam00912 956149009103 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 956149009104 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 956149009105 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 956149009106 ATP binding site [chemical binding]; other site 956149009107 putative Mg++ binding site [ion binding]; other site 956149009108 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 956149009109 nucleotide binding region [chemical binding]; other site 956149009110 ATP-binding site [chemical binding]; other site 956149009111 Helicase associated domain (HA2); Region: HA2; pfam04408 956149009112 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 956149009113 2'-5' RNA ligase; Provisional; Region: PRK15124 956149009114 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 956149009115 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 956149009116 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 956149009117 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 956149009118 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 956149009119 active site 956149009120 HIGH motif; other site 956149009121 KMSKS motif; other site 956149009122 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 956149009123 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 956149009124 active site 956149009125 NTP binding site [chemical binding]; other site 956149009126 metal binding triad [ion binding]; metal-binding site 956149009127 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 956149009128 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 956149009129 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 956149009130 catalytic center binding site [active] 956149009131 ATP binding site [chemical binding]; other site 956149009132 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 956149009133 oligomerization interface [polypeptide binding]; other site 956149009134 active site 956149009135 metal binding site [ion binding]; metal-binding site 956149009136 pantoate--beta-alanine ligase; Region: panC; TIGR00018 956149009137 Pantoate-beta-alanine ligase; Region: PanC; cd00560 956149009138 active site 956149009139 ATP-binding site [chemical binding]; other site 956149009140 pantoate-binding site; other site 956149009141 HXXH motif; other site 956149009142 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 956149009143 tetramerization interface [polypeptide binding]; other site 956149009144 active site 956149009145 Bacterial SH3 domain; Region: SH3_3; cl17532 956149009146 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 956149009147 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 956149009148 putative active site [active] 956149009149 putative metal binding site [ion binding]; other site 956149009150 inner membrane transport permease; Provisional; Region: PRK15066 956149009151 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 956149009152 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 956149009153 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 956149009154 Walker A/P-loop; other site 956149009155 ATP binding site [chemical binding]; other site 956149009156 Q-loop/lid; other site 956149009157 ABC transporter signature motif; other site 956149009158 Walker B; other site 956149009159 D-loop; other site 956149009160 H-loop/switch region; other site 956149009161 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 956149009162 active site clefts [active] 956149009163 zinc binding site [ion binding]; other site 956149009164 dimer interface [polypeptide binding]; other site 956149009165 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 956149009166 active site 956149009167 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 956149009168 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 956149009169 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 956149009170 Trp docking motif [polypeptide binding]; other site 956149009171 putative active site [active] 956149009172 multicopper oxidase; Provisional; Region: PRK10965 956149009173 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 956149009174 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 956149009175 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 956149009176 spermidine synthase; Provisional; Region: PRK00811 956149009177 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 956149009178 S-adenosylmethionine binding site [chemical binding]; other site 956149009179 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 956149009180 hypothetical protein; Provisional; Region: PRK05248 956149009181 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 956149009182 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 956149009183 substrate binding site [chemical binding]; other site 956149009184 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 956149009185 substrate binding site [chemical binding]; other site 956149009186 ligand binding site [chemical binding]; other site 956149009187 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 956149009188 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 956149009189 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 956149009190 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 956149009191 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 956149009192 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 956149009193 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 956149009194 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 956149009195 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 956149009196 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 956149009197 E3 interaction surface; other site 956149009198 lipoyl attachment site [posttranslational modification]; other site 956149009199 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 956149009200 E3 interaction surface; other site 956149009201 lipoyl attachment site [posttranslational modification]; other site 956149009202 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 956149009203 E3 interaction surface; other site 956149009204 lipoyl attachment site [posttranslational modification]; other site 956149009205 e3 binding domain; Region: E3_binding; pfam02817 956149009206 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 956149009207 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 956149009208 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 956149009209 dimer interface [polypeptide binding]; other site 956149009210 TPP-binding site [chemical binding]; other site 956149009211 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 956149009212 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 956149009213 DNA-binding site [nucleotide binding]; DNA binding site 956149009214 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 956149009215 aromatic amino acid transporter; Provisional; Region: PRK10238 956149009216 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 956149009217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149009218 putative substrate translocation pore; other site 956149009219 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 956149009220 active site 956149009221 regulatory protein AmpE; Provisional; Region: PRK10987 956149009222 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 956149009223 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 956149009224 amidase catalytic site [active] 956149009225 substrate binding site [chemical binding]; other site 956149009226 Zn binding residues [ion binding]; other site 956149009227 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 956149009228 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 956149009229 dimerization interface [polypeptide binding]; other site 956149009230 active site 956149009231 putative major pilin subunit; Provisional; Region: PRK10574 956149009232 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 956149009233 Pilin (bacterial filament); Region: Pilin; pfam00114 956149009234 hypothetical protein; Provisional; Region: PRK10436 956149009235 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 956149009236 Walker A motif; other site 956149009237 ATP binding site [chemical binding]; other site 956149009238 Walker B motif; other site 956149009239 type IV pilin biogenesis protein; Provisional; Region: PRK10573 956149009240 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 956149009241 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 956149009242 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 956149009243 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 956149009244 active site 956149009245 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 956149009246 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 956149009247 CoA-binding site [chemical binding]; other site 956149009248 ATP-binding [chemical binding]; other site 956149009249 hypothetical protein; Provisional; Region: PRK05287 956149009250 DNA gyrase inhibitor; Reviewed; Region: PRK00418 956149009251 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 956149009252 active site 956149009253 8-oxo-dGMP binding site [chemical binding]; other site 956149009254 nudix motif; other site 956149009255 metal binding site [ion binding]; metal-binding site 956149009256 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 956149009257 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 956149009258 SEC-C motif; Region: SEC-C; pfam02810 956149009259 SecA regulator SecM; Provisional; Region: PRK02943 956149009260 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 956149009261 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 956149009262 cell division protein FtsZ; Validated; Region: PRK09330 956149009263 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 956149009264 nucleotide binding site [chemical binding]; other site 956149009265 SulA interaction site; other site 956149009266 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 956149009267 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 956149009268 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 956149009269 Cell division protein FtsA; Region: FtsA; pfam14450 956149009270 cell division protein FtsQ; Provisional; Region: PRK10775 956149009271 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 956149009272 Cell division protein FtsQ; Region: FtsQ; pfam03799 956149009273 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 956149009274 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 956149009275 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 956149009276 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 956149009277 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 956149009278 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 956149009279 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 956149009280 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 956149009281 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 956149009282 active site 956149009283 homodimer interface [polypeptide binding]; other site 956149009284 cell division protein FtsW; Provisional; Region: PRK10774 956149009285 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 956149009286 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 956149009287 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 956149009288 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 956149009289 Mg++ binding site [ion binding]; other site 956149009290 putative catalytic motif [active] 956149009291 putative substrate binding site [chemical binding]; other site 956149009292 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 956149009293 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 956149009294 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 956149009295 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 956149009296 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 956149009297 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 956149009298 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 956149009299 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 956149009300 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 956149009301 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 956149009302 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 956149009303 cell division protein FtsL; Provisional; Region: PRK10772 956149009304 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 956149009305 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 956149009306 cell division protein MraZ; Reviewed; Region: PRK00326 956149009307 MraZ protein; Region: MraZ; pfam02381 956149009308 MraZ protein; Region: MraZ; pfam02381 956149009309 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 956149009310 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 956149009311 DNA binding site [nucleotide binding] 956149009312 domain linker motif; other site 956149009313 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 956149009314 dimerization interface [polypeptide binding]; other site 956149009315 ligand binding site [chemical binding]; other site 956149009316 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 956149009317 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 956149009318 putative valine binding site [chemical binding]; other site 956149009319 dimer interface [polypeptide binding]; other site 956149009320 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 956149009321 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 956149009322 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 956149009323 PYR/PP interface [polypeptide binding]; other site 956149009324 dimer interface [polypeptide binding]; other site 956149009325 TPP binding site [chemical binding]; other site 956149009326 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 956149009327 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 956149009328 TPP-binding site [chemical binding]; other site 956149009329 dimer interface [polypeptide binding]; other site 956149009330 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 956149009331 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149009332 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 956149009333 putative substrate binding pocket [chemical binding]; other site 956149009334 putative dimerization interface [polypeptide binding]; other site 956149009335 2-isopropylmalate synthase; Validated; Region: PRK00915 956149009336 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 956149009337 active site 956149009338 catalytic residues [active] 956149009339 metal binding site [ion binding]; metal-binding site 956149009340 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 956149009341 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 956149009342 tartrate dehydrogenase; Region: TTC; TIGR02089 956149009343 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 956149009344 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 956149009345 substrate binding site [chemical binding]; other site 956149009346 ligand binding site [chemical binding]; other site 956149009347 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 956149009348 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 956149009349 substrate binding site [chemical binding]; other site 956149009350 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149009351 sugar efflux transporter; Region: 2A0120; TIGR00899 956149009352 putative substrate translocation pore; other site 956149009353 transcriptional regulator SgrR; Provisional; Region: PRK13626 956149009354 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 956149009355 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 956149009356 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 956149009357 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 956149009358 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 956149009359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149009360 dimer interface [polypeptide binding]; other site 956149009361 conserved gate region; other site 956149009362 putative PBP binding loops; other site 956149009363 ABC-ATPase subunit interface; other site 956149009364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149009365 dimer interface [polypeptide binding]; other site 956149009366 conserved gate region; other site 956149009367 putative PBP binding loops; other site 956149009368 ABC-ATPase subunit interface; other site 956149009369 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 956149009370 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 956149009371 Walker A/P-loop; other site 956149009372 ATP binding site [chemical binding]; other site 956149009373 Q-loop/lid; other site 956149009374 ABC transporter signature motif; other site 956149009375 Walker B; other site 956149009376 D-loop; other site 956149009377 H-loop/switch region; other site 956149009378 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 956149009379 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 956149009380 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 956149009381 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 956149009382 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 956149009383 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 956149009384 ribulokinase; Provisional; Region: PRK04123 956149009385 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 956149009386 N- and C-terminal domain interface [polypeptide binding]; other site 956149009387 active site 956149009388 MgATP binding site [chemical binding]; other site 956149009389 catalytic site [active] 956149009390 metal binding site [ion binding]; metal-binding site 956149009391 carbohydrate binding site [chemical binding]; other site 956149009392 homodimer interface [polypeptide binding]; other site 956149009393 L-arabinose isomerase; Provisional; Region: PRK02929 956149009394 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 956149009395 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 956149009396 trimer interface [polypeptide binding]; other site 956149009397 putative substrate binding site [chemical binding]; other site 956149009398 putative metal binding site [ion binding]; other site 956149009399 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 956149009400 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 956149009401 intersubunit interface [polypeptide binding]; other site 956149009402 active site 956149009403 Zn2+ binding site [ion binding]; other site 956149009404 Uncharacterized conserved protein [Function unknown]; Region: COG4748 956149009405 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 956149009406 DNA polymerase II; Reviewed; Region: PRK05762 956149009407 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 956149009408 active site 956149009409 catalytic site [active] 956149009410 substrate binding site [chemical binding]; other site 956149009411 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 956149009412 active site 956149009413 metal-binding site 956149009414 ATP-dependent helicase HepA; Validated; Region: PRK04914 956149009415 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 956149009416 ATP binding site [chemical binding]; other site 956149009417 putative Mg++ binding site [ion binding]; other site 956149009418 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 956149009419 nucleotide binding region [chemical binding]; other site 956149009420 ATP-binding site [chemical binding]; other site 956149009421 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 956149009422 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 956149009423 active site 956149009424 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 956149009425 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 956149009426 putative metal binding site [ion binding]; other site 956149009427 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 956149009428 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 956149009429 OstA-like protein; Region: OstA; pfam03968 956149009430 Organic solvent tolerance protein; Region: OstA_C; pfam04453 956149009431 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 956149009432 SurA N-terminal domain; Region: SurA_N; pfam09312 956149009433 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 956149009434 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 956149009435 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 956149009436 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 956149009437 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 956149009438 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 956149009439 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 956149009440 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 956149009441 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 956149009442 active site 956149009443 metal binding site [ion binding]; metal-binding site 956149009444 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 956149009445 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 956149009446 folate binding site [chemical binding]; other site 956149009447 NADP+ binding site [chemical binding]; other site 956149009448 LysE type translocator; Region: LysE; cl00565 956149009449 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 956149009450 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 956149009451 TrkA-N domain; Region: TrkA_N; pfam02254 956149009452 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 956149009453 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 956149009454 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 956149009455 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 956149009456 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 956149009457 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 956149009458 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 956149009459 ATP-grasp domain; Region: ATP-grasp_4; cl17255 956149009460 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 956149009461 IMP binding site; other site 956149009462 dimer interface [polypeptide binding]; other site 956149009463 interdomain contacts; other site 956149009464 partial ornithine binding site; other site 956149009465 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 956149009466 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 956149009467 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 956149009468 catalytic site [active] 956149009469 subunit interface [polypeptide binding]; other site 956149009470 dihydrodipicolinate reductase; Provisional; Region: PRK00048 956149009471 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 956149009472 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 956149009473 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 956149009474 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 956149009475 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 956149009476 putative active site [active] 956149009477 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 956149009478 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 956149009479 active site 956149009480 phosphorylation site [posttranslational modification] 956149009481 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 956149009482 active site 956149009483 P-loop; other site 956149009484 phosphorylation site [posttranslational modification] 956149009485 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 956149009486 alpha-mannosidase; Provisional; Region: PRK09819 956149009487 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 956149009488 active site 956149009489 metal binding site [ion binding]; metal-binding site 956149009490 catalytic site [active] 956149009491 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 956149009492 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 956149009493 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 956149009494 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 956149009495 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 956149009496 Transcriptional regulator [Transcription]; Region: LysR; COG0583 956149009497 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149009498 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 956149009499 putative effector binding pocket; other site 956149009500 dimerization interface [polypeptide binding]; other site 956149009501 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 956149009502 active site 956149009503 tetramer interface [polypeptide binding]; other site 956149009504 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 956149009505 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 956149009506 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 956149009507 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 956149009508 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 956149009509 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 956149009510 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 956149009511 active site 956149009512 HIGH motif; other site 956149009513 nucleotide binding site [chemical binding]; other site 956149009514 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 956149009515 active site 956149009516 KMSKS motif; other site 956149009517 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 956149009518 tRNA binding surface [nucleotide binding]; other site 956149009519 anticodon binding site; other site 956149009520 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 956149009521 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 956149009522 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 956149009523 active site 956149009524 Riboflavin kinase; Region: Flavokinase; smart00904 956149009525 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 956149009526 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 956149009527 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149009528 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 956149009529 putative dimerization interface [polypeptide binding]; other site 956149009530 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 956149009531 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 956149009532 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 956149009533 active site 956149009534 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 956149009535 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 956149009536 aromatic chitin/cellulose binding site residues [chemical binding]; other site 956149009537 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 956149009538 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 956149009539 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 956149009540 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 956149009541 Transcriptional regulator [Transcription]; Region: LysR; COG0583 956149009542 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149009543 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 956149009544 chaperone protein DnaJ; Provisional; Region: PRK10767 956149009545 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 956149009546 HSP70 interaction site [polypeptide binding]; other site 956149009547 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 956149009548 substrate binding site [polypeptide binding]; other site 956149009549 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 956149009550 Zn binding sites [ion binding]; other site 956149009551 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 956149009552 dimer interface [polypeptide binding]; other site 956149009553 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 956149009554 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 956149009555 nucleotide binding site [chemical binding]; other site 956149009556 hypothetical protein; Provisional; Region: PRK10659 956149009557 metabolite-proton symporter; Region: 2A0106; TIGR00883 956149009558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149009559 putative substrate translocation pore; other site 956149009560 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 956149009561 MPT binding site; other site 956149009562 trimer interface [polypeptide binding]; other site 956149009563 transaldolase-like protein; Provisional; Region: PTZ00411 956149009564 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 956149009565 active site 956149009566 dimer interface [polypeptide binding]; other site 956149009567 catalytic residue [active] 956149009568 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 956149009569 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 956149009570 hypothetical protein; Validated; Region: PRK02101 956149009571 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 956149009572 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 956149009573 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149009574 catalytic residue [active] 956149009575 homoserine kinase; Provisional; Region: PRK01212 956149009576 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 956149009577 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 956149009578 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 956149009579 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 956149009580 putative catalytic residues [active] 956149009581 putative nucleotide binding site [chemical binding]; other site 956149009582 putative aspartate binding site [chemical binding]; other site 956149009583 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 956149009584 dimer interface [polypeptide binding]; other site 956149009585 putative threonine allosteric regulatory site; other site 956149009586 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 956149009587 putative threonine allosteric regulatory site; other site 956149009588 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 956149009589 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 956149009590 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 956149009591 putative RNA methyltransferase; Provisional; Region: PRK10433 956149009592 two-component response regulator; Provisional; Region: PRK11173 956149009593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 956149009594 active site 956149009595 phosphorylation site [posttranslational modification] 956149009596 intermolecular recognition site; other site 956149009597 dimerization interface [polypeptide binding]; other site 956149009598 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 956149009599 DNA binding site [nucleotide binding] 956149009600 inner membrane protein; Provisional; Region: PRK11715 956149009601 sensory histidine kinase CreC; Provisional; Region: PRK11100 956149009602 HAMP domain; Region: HAMP; pfam00672 956149009603 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 956149009604 dimer interface [polypeptide binding]; other site 956149009605 phosphorylation site [posttranslational modification] 956149009606 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 956149009607 ATP binding site [chemical binding]; other site 956149009608 Mg2+ binding site [ion binding]; other site 956149009609 G-X-G motif; other site 956149009610 DNA-binding response regulator CreB; Provisional; Region: PRK11083 956149009611 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 956149009612 active site 956149009613 phosphorylation site [posttranslational modification] 956149009614 intermolecular recognition site; other site 956149009615 dimerization interface [polypeptide binding]; other site 956149009616 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 956149009617 DNA binding site [nucleotide binding] 956149009618 hypothetical protein; Provisional; Region: PRK10756 956149009619 CreA protein; Region: CreA; pfam05981 956149009620 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 956149009621 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 956149009622 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 956149009623 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 956149009624 catalytic core [active] 956149009625 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 956149009626 Trp operon repressor; Provisional; Region: PRK01381 956149009627 lytic murein transglycosylase; Provisional; Region: PRK11619 956149009628 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 956149009629 N-acetyl-D-glucosamine binding site [chemical binding]; other site 956149009630 catalytic residue [active] 956149009631 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 956149009632 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 956149009633 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 956149009634 ABC transporter; Region: ABC_tran_2; pfam12848 956149009635 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 956149009636 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 956149009637 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 956149009638 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 956149009639 potential frameshift: common BLAST hit: gi|389842329|ref|YP_006344413.1| capsule polysaccharide export protein KpsC 956149009640 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 956149009641 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 956149009642 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 956149009643 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 956149009644 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 956149009645 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 956149009646 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 956149009647 Walker A/P-loop; other site 956149009648 ATP binding site [chemical binding]; other site 956149009649 Q-loop/lid; other site 956149009650 ABC transporter signature motif; other site 956149009651 Walker B; other site 956149009652 D-loop; other site 956149009653 H-loop/switch region; other site 956149009654 ABC-2 type transporter; Region: ABC2_membrane; cl17235 956149009655 Transcriptional regulator [Transcription]; Region: LysR; COG0583 956149009656 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149009657 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 956149009658 putative effector binding pocket; other site 956149009659 dimerization interface [polypeptide binding]; other site 956149009660 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 956149009661 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 956149009662 putative NAD(P) binding site [chemical binding]; other site 956149009663 dimer interface [polypeptide binding]; other site 956149009664 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 956149009665 non-specific DNA binding site [nucleotide binding]; other site 956149009666 salt bridge; other site 956149009667 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 956149009668 sequence-specific DNA binding site [nucleotide binding]; other site 956149009669 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 956149009670 active site 956149009671 (T/H)XGH motif; other site 956149009672 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 956149009673 DNA repair protein RadA; Region: sms; TIGR00416 956149009674 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 956149009675 Walker A motif/ATP binding site; other site 956149009676 ATP binding site [chemical binding]; other site 956149009677 Walker B motif; other site 956149009678 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 956149009679 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 956149009680 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 956149009681 motif II; other site 956149009682 hypothetical protein; Provisional; Region: PRK11246 956149009683 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 956149009684 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 956149009685 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 956149009686 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 956149009687 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 956149009688 phosphopentomutase; Provisional; Region: PRK05362 956149009689 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 956149009690 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 956149009691 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 956149009692 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 956149009693 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 956149009694 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 956149009695 intersubunit interface [polypeptide binding]; other site 956149009696 active site 956149009697 catalytic residue [active] 956149009698 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 956149009699 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 956149009700 Nucleoside recognition; Region: Gate; pfam07670 956149009701 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 956149009702 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 956149009703 active site 956149009704 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 956149009705 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 956149009706 active site 956149009707 nucleophile elbow; other site 956149009708 periplasmic protein; Provisional; Region: PRK10568 956149009709 BON domain; Region: BON; pfam04972 956149009710 BON domain; Region: BON; pfam04972 956149009711 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 956149009712 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 956149009713 G1 box; other site 956149009714 putative GEF interaction site [polypeptide binding]; other site 956149009715 GTP/Mg2+ binding site [chemical binding]; other site 956149009716 Switch I region; other site 956149009717 G2 box; other site 956149009718 G3 box; other site 956149009719 Switch II region; other site 956149009720 G4 box; other site 956149009721 G5 box; other site 956149009722 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 956149009723 dUMP phosphatase; Provisional; Region: PRK09449 956149009724 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 956149009725 motif II; other site 956149009726 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 956149009727 Coenzyme A binding pocket [chemical binding]; other site 956149009728 DNA polymerase III psi subunit; Region: DNA_III_psi; pfam03603 956149009729 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 956149009730 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 956149009731 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 956149009732 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 956149009733 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 956149009734 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 956149009735 metal binding site [ion binding]; metal-binding site 956149009736 active site 956149009737 I-site; other site 956149009738 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 956149009739 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 956149009740 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 956149009741 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 956149009742 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 956149009743 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 956149009744 putative deacylase active site [active] 956149009745 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 956149009746 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 956149009747 DNA binding residues [nucleotide binding] 956149009748 dimerization interface [polypeptide binding]; other site 956149009749 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 956149009750 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 956149009751 DNA binding residues [nucleotide binding] 956149009752 dimerization interface [polypeptide binding]; other site 956149009753 Uncharacterized conserved protein [Function unknown]; Region: COG2966 956149009754 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 956149009755 hypothetical protein; Provisional; Region: PRK09917 956149009756 Transcriptional regulators [Transcription]; Region: MarR; COG1846 956149009757 MarR family; Region: MarR; pfam01047 956149009758 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 956149009759 primosomal protein DnaI; Provisional; Region: PRK02854 956149009760 DNA replication protein DnaC; Validated; Region: PRK07952 956149009761 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 956149009762 Walker A motif; other site 956149009763 ATP binding site [chemical binding]; other site 956149009764 Walker B motif; other site 956149009765 phosphoglycerol transferase I; Provisional; Region: PRK03776 956149009766 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 956149009767 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 956149009768 GAF domain; Region: GAF; pfam01590 956149009769 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 956149009770 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 956149009771 metal binding site [ion binding]; metal-binding site 956149009772 active site 956149009773 I-site; other site 956149009774 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 956149009775 dimerization interface [polypeptide binding]; other site 956149009776 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 956149009777 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 956149009778 metal binding site [ion binding]; metal-binding site 956149009779 active site 956149009780 I-site; other site 956149009781 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 956149009782 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 956149009783 dimer interface [polypeptide binding]; other site 956149009784 ligand binding site [chemical binding]; other site 956149009785 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 956149009786 dimerization interface [polypeptide binding]; other site 956149009787 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 956149009788 dimer interface [polypeptide binding]; other site 956149009789 putative CheW interface [polypeptide binding]; other site 956149009790 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 956149009791 catalytic triad [active] 956149009792 putative active site [active] 956149009793 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 956149009794 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 956149009795 Autotransporter beta-domain; Region: Autotransporter; pfam03797 956149009796 cytosine deaminase; Provisional; Region: PRK09230 956149009797 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 956149009798 active site 956149009799 cytosine permease; Provisional; Region: codB; PRK11017 956149009800 Na binding site [ion binding]; other site 956149009801 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 956149009802 beta-galactosidase; Region: BGL; TIGR03356 956149009803 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 956149009804 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 956149009805 active site turn [active] 956149009806 phosphorylation site [posttranslational modification] 956149009807 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 956149009808 Transcriptional regulators [Transcription]; Region: PurR; COG1609 956149009809 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 956149009810 DNA binding site [nucleotide binding] 956149009811 domain linker motif; other site 956149009812 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 956149009813 dimerization interface (closed form) [polypeptide binding]; other site 956149009814 ligand binding site [chemical binding]; other site 956149009815 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 956149009816 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 956149009817 HlyD family secretion protein; Region: HlyD_3; pfam13437 956149009818 transcriptional regulator SlyA; Provisional; Region: PRK03573 956149009819 MarR family; Region: MarR_2; cl17246 956149009820 lac repressor; Reviewed; Region: lacI; PRK09526 956149009821 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 956149009822 DNA binding site [nucleotide binding] 956149009823 domain linker motif; other site 956149009824 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 956149009825 ligand binding site [chemical binding]; other site 956149009826 dimerization interface (open form) [polypeptide binding]; other site 956149009827 dimerization interface (closed form) [polypeptide binding]; other site 956149009828 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 956149009829 trimer interface; other site 956149009830 sugar binding site [chemical binding]; other site 956149009831 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 956149009832 active site turn [active] 956149009833 phosphorylation site [posttranslational modification] 956149009834 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 956149009835 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 956149009836 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 956149009837 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 956149009838 Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism]; Region: COG3867 956149009839 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 956149009840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149009841 dimer interface [polypeptide binding]; other site 956149009842 conserved gate region; other site 956149009843 putative PBP binding loops; other site 956149009844 ABC-ATPase subunit interface; other site 956149009845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149009846 dimer interface [polypeptide binding]; other site 956149009847 conserved gate region; other site 956149009848 ABC-ATPase subunit interface; other site 956149009849 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 956149009850 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 956149009851 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 956149009852 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 956149009853 Walker A/P-loop; other site 956149009854 ATP binding site [chemical binding]; other site 956149009855 Q-loop/lid; other site 956149009856 ABC transporter signature motif; other site 956149009857 Walker B; other site 956149009858 D-loop; other site 956149009859 H-loop/switch region; other site 956149009860 TOBE domain; Region: TOBE; cl01440 956149009861 TOBE domain; Region: TOBE_2; pfam08402 956149009862 endoribonuclease SymE; Provisional; Region: PRK13605 956149009863 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 956149009864 potential frameshift: common BLAST hit: gi|389842396|ref|YP_006344480.1| HTH-type transcriptional regulator YjiR 956149009865 Protein of unknown function (DUF445); Region: DUF445; pfam04286 956149009866 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 956149009867 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 956149009868 nucleotide binding region [chemical binding]; other site 956149009869 ATP-binding site [chemical binding]; other site 956149009870 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 956149009871 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 956149009872 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 956149009873 dimer interface [polypeptide binding]; other site 956149009874 active site 956149009875 metal binding site [ion binding]; metal-binding site 956149009876 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 956149009877 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 956149009878 non-specific DNA binding site [nucleotide binding]; other site 956149009879 salt bridge; other site 956149009880 sequence-specific DNA binding site [nucleotide binding]; other site 956149009881 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 956149009882 SIR2-like domain; Region: SIR2_2; pfam13289 956149009883 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 956149009884 DNA binding site [nucleotide binding] 956149009885 Int/Topo IB signature motif; other site 956149009886 active site 956149009887 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 956149009888 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 956149009889 active site 956149009890 DNA binding site [nucleotide binding] 956149009891 Int/Topo IB signature motif; other site 956149009892 Eco47II restriction endonuclease; Region: RE_Eco47II; pfam09553 956149009893 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 956149009894 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 956149009895 DNA binding residues [nucleotide binding] 956149009896 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 956149009897 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 956149009898 cofactor binding site; other site 956149009899 DNA binding site [nucleotide binding] 956149009900 substrate interaction site [chemical binding]; other site 956149009901 Recombination endonuclease VII; Region: Endonuclease_7; pfam02945 956149009902 HNH endonuclease; Region: HNH_3; pfam13392 956149009903 capsid protein; Region: PHA02004 956149009904 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 956149009905 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 956149009906 ATP binding site [chemical binding]; other site 956149009907 putative Mg++ binding site [ion binding]; other site 956149009908 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 956149009909 nucleotide binding region [chemical binding]; other site 956149009910 ATP-binding site [chemical binding]; other site 956149009911 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 956149009912 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 956149009913 catalytic residues [active] 956149009914 catalytic nucleophile [active] 956149009915 Presynaptic Site I dimer interface [polypeptide binding]; other site 956149009916 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 956149009917 Synaptic Flat tetramer interface [polypeptide binding]; other site 956149009918 Synaptic Site I dimer interface [polypeptide binding]; other site 956149009919 DNA binding site [nucleotide binding] 956149009920 DNA-binding interface [nucleotide binding]; DNA binding site 956149009921 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 956149009922 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 956149009923 active site 956149009924 Methyltransferase domain; Region: Methyltransf_23; pfam13489 956149009925 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 956149009926 S-adenosylmethionine binding site [chemical binding]; other site 956149009927 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 956149009928 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 956149009929 DNA binding residues [nucleotide binding] 956149009930 dimerization interface [polypeptide binding]; other site 956149009931 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 956149009932 active site 956149009933 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 956149009934 catalytic residues [active] 956149009935 Protein of unknown function (DUF2589); Region: DUF2589; pfam11655 956149009936 Protein of unknown function (DUF2589); Region: DUF2589; pfam11655 956149009937 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 956149009938 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 956149009939 putative NAD(P) binding site [chemical binding]; other site 956149009940 putative substrate binding site [chemical binding]; other site 956149009941 catalytic Zn binding site [ion binding]; other site 956149009942 structural Zn binding site [ion binding]; other site 956149009943 dimer interface [polypeptide binding]; other site 956149009944 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 956149009945 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 956149009946 Zn binding sites [ion binding]; other site 956149009947 dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361 956149009948 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 956149009949 DAK2 domain; Region: Dak2; pfam02734 956149009950 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 956149009951 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 956149009952 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 956149009953 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 956149009954 multifunctional aminopeptidase A; Provisional; Region: PRK00913 956149009955 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 956149009956 interface (dimer of trimers) [polypeptide binding]; other site 956149009957 Substrate-binding/catalytic site; other site 956149009958 Zn-binding sites [ion binding]; other site 956149009959 DNA polymerase III subunit chi; Validated; Region: PRK05728 956149009960 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 956149009961 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 956149009962 HIGH motif; other site 956149009963 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 956149009964 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 956149009965 active site 956149009966 KMSKS motif; other site 956149009967 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 956149009968 tRNA binding surface [nucleotide binding]; other site 956149009969 anticodon binding site; other site 956149009970 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 956149009971 Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987 956149009972 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 956149009973 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 956149009974 Coenzyme A binding pocket [chemical binding]; other site 956149009975 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 956149009976 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 956149009977 active site 956149009978 dinuclear metal binding site [ion binding]; other site 956149009979 dimerization interface [polypeptide binding]; other site 956149009980 RNase E inhibitor protein; Provisional; Region: PRK11191 956149009981 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 956149009982 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 956149009983 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 956149009984 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 956149009985 arginine deiminase; Provisional; Region: PRK01388 956149009986 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 956149009987 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 956149009988 putative substrate binding site [chemical binding]; other site 956149009989 nucleotide binding site [chemical binding]; other site 956149009990 nucleotide binding site [chemical binding]; other site 956149009991 homodimer interface [polypeptide binding]; other site 956149009992 ornithine carbamoyltransferase; Validated; Region: PRK02102 956149009993 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 956149009994 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 956149009995 Predicted membrane protein [Function unknown]; Region: COG1288 956149009996 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 956149009997 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 956149009998 Arginine repressor [Transcription]; Region: ArgR; COG1438 956149009999 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 956149010000 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 956149010001 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 956149010002 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 956149010003 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 956149010004 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 956149010005 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 956149010006 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 956149010007 homotrimer interaction site [polypeptide binding]; other site 956149010008 putative active site [active] 956149010009 hypothetical protein; Provisional; Region: PRK01254 956149010010 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 956149010011 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 956149010012 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 956149010013 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 956149010014 FAD binding pocket [chemical binding]; other site 956149010015 FAD binding motif [chemical binding]; other site 956149010016 phosphate binding motif [ion binding]; other site 956149010017 NAD binding pocket [chemical binding]; other site 956149010018 Predicted transcriptional regulators [Transcription]; Region: COG1695 956149010019 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 956149010020 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 956149010021 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 956149010022 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 956149010023 dimerization interface [polypeptide binding]; other site 956149010024 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 956149010025 dimer interface [polypeptide binding]; other site 956149010026 putative CheW interface [polypeptide binding]; other site 956149010027 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 956149010028 PAS domain; Region: PAS_9; pfam13426 956149010029 putative active site [active] 956149010030 heme pocket [chemical binding]; other site 956149010031 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 956149010032 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 956149010033 dimer interface [polypeptide binding]; other site 956149010034 putative CheW interface [polypeptide binding]; other site 956149010035 diguanylate cyclase; Provisional; Region: PRK09894 956149010036 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 956149010037 metal binding site [ion binding]; metal-binding site 956149010038 active site 956149010039 I-site; other site 956149010040 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 956149010041 inhibitor-cofactor binding pocket; inhibition site 956149010042 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149010043 catalytic residue [active] 956149010044 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 956149010045 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 956149010046 active site 956149010047 FMN binding site [chemical binding]; other site 956149010048 2,4-decadienoyl-CoA binding site; other site 956149010049 catalytic residue [active] 956149010050 4Fe-4S cluster binding site [ion binding]; other site 956149010051 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 956149010052 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 956149010053 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 956149010054 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 956149010055 S-adenosylmethionine binding site [chemical binding]; other site 956149010056 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 956149010057 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 956149010058 putative active site [active] 956149010059 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 956149010060 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 956149010061 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 956149010062 serine/threonine transporter SstT; Provisional; Region: PRK13628 956149010063 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 956149010064 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 956149010065 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 956149010066 galactarate dehydratase; Region: galactar-dH20; TIGR03248 956149010067 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 956149010068 Glucuronate isomerase; Region: UxaC; pfam02614 956149010069 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 956149010070 D-galactonate transporter; Region: 2A0114; TIGR00893 956149010071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149010072 putative substrate translocation pore; other site 956149010073 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 956149010074 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 956149010075 DNA-binding site [nucleotide binding]; DNA binding site 956149010076 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 956149010077 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 956149010078 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 956149010079 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 956149010080 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 956149010081 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 956149010082 Predicted membrane protein [Function unknown]; Region: COG5393 956149010083 YqjK-like protein; Region: YqjK; pfam13997 956149010084 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 956149010085 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 956149010086 hypothetical protein; Provisional; Region: PRK15301 956149010087 putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304 956149010088 PapC N-terminal domain; Region: PapC_N; pfam13954 956149010089 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 956149010090 PapC C-terminal domain; Region: PapC_C; pfam13953 956149010091 putative fimbrial chaperone protein; Provisional; Region: PRK09918 956149010092 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 956149010093 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 956149010094 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 956149010095 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 956149010096 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 956149010097 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 956149010098 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 956149010099 Predicted membrane protein [Function unknown]; Region: COG2259 956149010100 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 956149010101 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 956149010102 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 956149010103 putative dimer interface [polypeptide binding]; other site 956149010104 N-terminal domain interface [polypeptide binding]; other site 956149010105 putative substrate binding pocket (H-site) [chemical binding]; other site 956149010106 Predicted membrane protein [Function unknown]; Region: COG3152 956149010107 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 956149010108 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 956149010109 putative substrate binding site [chemical binding]; other site 956149010110 putative ATP binding site [chemical binding]; other site 956149010111 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 956149010112 trimer interface; other site 956149010113 sugar binding site [chemical binding]; other site 956149010114 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 956149010115 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 956149010116 active site turn [active] 956149010117 phosphorylation site [posttranslational modification] 956149010118 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 956149010119 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 956149010120 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 956149010121 substrate binding [chemical binding]; other site 956149010122 active site 956149010123 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 956149010124 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 956149010125 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 956149010126 DNA binding site [nucleotide binding] 956149010127 domain linker motif; other site 956149010128 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 956149010129 dimerization interface [polypeptide binding]; other site 956149010130 ligand binding site [chemical binding]; other site 956149010131 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149010132 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 956149010133 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 956149010134 dimerization interface [polypeptide binding]; other site 956149010135 Pirin-related protein [General function prediction only]; Region: COG1741 956149010136 Pirin; Region: Pirin; pfam02678 956149010137 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 956149010138 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 956149010139 putative SAM binding site [chemical binding]; other site 956149010140 putative homodimer interface [polypeptide binding]; other site 956149010141 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 956149010142 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 956149010143 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 956149010144 putative ligand binding site [chemical binding]; other site 956149010145 TIGR00252 family protein; Region: TIGR00252 956149010146 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 956149010147 dimer interface [polypeptide binding]; other site 956149010148 active site 956149010149 outer membrane lipoprotein; Provisional; Region: PRK11023 956149010150 BON domain; Region: BON; pfam04972 956149010151 BON domain; Region: BON; pfam04972 956149010152 Predicted permease; Region: DUF318; pfam03773 956149010153 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 956149010154 NADH(P)-binding; Region: NAD_binding_10; pfam13460 956149010155 NAD binding site [chemical binding]; other site 956149010156 active site 956149010157 intracellular protease, PfpI family; Region: PfpI; TIGR01382 956149010158 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 956149010159 proposed catalytic triad [active] 956149010160 conserved cys residue [active] 956149010161 hypothetical protein; Provisional; Region: PRK03467 956149010162 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 956149010163 GIY-YIG motif/motif A; other site 956149010164 putative active site [active] 956149010165 putative metal binding site [ion binding]; other site 956149010166 putative acetyltransferase; Provisional; Region: PRK03624 956149010167 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 956149010168 Coenzyme A binding pocket [chemical binding]; other site 956149010169 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 956149010170 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 956149010171 Peptidase family U32; Region: Peptidase_U32; pfam01136 956149010172 putative protease; Provisional; Region: PRK15447 956149010173 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 956149010174 hypothetical protein; Provisional; Region: PRK10508 956149010175 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 956149010176 tryptophan permease; Provisional; Region: PRK10483 956149010177 aromatic amino acid transport protein; Region: araaP; TIGR00837 956149010178 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 956149010179 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 956149010180 ATP binding site [chemical binding]; other site 956149010181 Mg++ binding site [ion binding]; other site 956149010182 motif III; other site 956149010183 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 956149010184 nucleotide binding region [chemical binding]; other site 956149010185 ATP-binding site [chemical binding]; other site 956149010186 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 956149010187 putative RNA binding site [nucleotide binding]; other site 956149010188 lipoprotein NlpI; Provisional; Region: PRK11189 956149010189 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 956149010190 binding surface 956149010191 TPR motif; other site 956149010192 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 956149010193 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 956149010194 RNase E interface [polypeptide binding]; other site 956149010195 trimer interface [polypeptide binding]; other site 956149010196 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 956149010197 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 956149010198 RNase E interface [polypeptide binding]; other site 956149010199 trimer interface [polypeptide binding]; other site 956149010200 active site 956149010201 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 956149010202 putative nucleic acid binding region [nucleotide binding]; other site 956149010203 G-X-X-G motif; other site 956149010204 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 956149010205 RNA binding site [nucleotide binding]; other site 956149010206 domain interface; other site 956149010207 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 956149010208 16S/18S rRNA binding site [nucleotide binding]; other site 956149010209 S13e-L30e interaction site [polypeptide binding]; other site 956149010210 25S rRNA binding site [nucleotide binding]; other site 956149010211 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 956149010212 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 956149010213 RNA binding site [nucleotide binding]; other site 956149010214 active site 956149010215 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 956149010216 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 956149010217 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 956149010218 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 956149010219 translation initiation factor IF-2; Region: IF-2; TIGR00487 956149010220 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 956149010221 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 956149010222 G1 box; other site 956149010223 putative GEF interaction site [polypeptide binding]; other site 956149010224 GTP/Mg2+ binding site [chemical binding]; other site 956149010225 Switch I region; other site 956149010226 G2 box; other site 956149010227 G3 box; other site 956149010228 Switch II region; other site 956149010229 G4 box; other site 956149010230 G5 box; other site 956149010231 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 956149010232 Translation-initiation factor 2; Region: IF-2; pfam11987 956149010233 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 956149010234 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 956149010235 NusA N-terminal domain; Region: NusA_N; pfam08529 956149010236 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 956149010237 RNA binding site [nucleotide binding]; other site 956149010238 homodimer interface [polypeptide binding]; other site 956149010239 NusA-like KH domain; Region: KH_5; pfam13184 956149010240 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 956149010241 G-X-X-G motif; other site 956149010242 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 956149010243 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 956149010244 ribosome maturation protein RimP; Reviewed; Region: PRK00092 956149010245 Sm and related proteins; Region: Sm_like; cl00259 956149010246 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 956149010247 putative oligomer interface [polypeptide binding]; other site 956149010248 putative RNA binding site [nucleotide binding]; other site 956149010249 Preprotein translocase SecG subunit; Region: SecG; pfam03840 956149010250 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 956149010251 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 956149010252 active site 956149010253 substrate binding site [chemical binding]; other site 956149010254 metal binding site [ion binding]; metal-binding site 956149010255 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 956149010256 dihydropteroate synthase; Region: DHPS; TIGR01496 956149010257 substrate binding pocket [chemical binding]; other site 956149010258 dimer interface [polypeptide binding]; other site 956149010259 inhibitor binding site; inhibition site 956149010260 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 956149010261 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 956149010262 Walker A motif; other site 956149010263 ATP binding site [chemical binding]; other site 956149010264 Walker B motif; other site 956149010265 arginine finger; other site 956149010266 Peptidase family M41; Region: Peptidase_M41; pfam01434 956149010267 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 956149010268 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 956149010269 S-adenosylmethionine binding site [chemical binding]; other site 956149010270 RNA-binding protein YhbY; Provisional; Region: PRK10343 956149010271 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 956149010272 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 956149010273 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 956149010274 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 956149010275 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 956149010276 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 956149010277 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 956149010278 active site 956149010279 phosphorylation site [posttranslational modification] 956149010280 intermolecular recognition site; other site 956149010281 dimerization interface [polypeptide binding]; other site 956149010282 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 956149010283 DNA binding site [nucleotide binding] 956149010284 sensor protein BasS/PmrB; Provisional; Region: PRK10755 956149010285 HAMP domain; Region: HAMP; pfam00672 956149010286 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 956149010287 dimer interface [polypeptide binding]; other site 956149010288 phosphorylation site [posttranslational modification] 956149010289 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 956149010290 ATP binding site [chemical binding]; other site 956149010291 Mg2+ binding site [ion binding]; other site 956149010292 G-X-G motif; other site 956149010293 GTPase CgtA; Reviewed; Region: obgE; PRK12298 956149010294 GTP1/OBG; Region: GTP1_OBG; pfam01018 956149010295 Obg GTPase; Region: Obg; cd01898 956149010296 G1 box; other site 956149010297 GTP/Mg2+ binding site [chemical binding]; other site 956149010298 Switch I region; other site 956149010299 G2 box; other site 956149010300 G3 box; other site 956149010301 Switch II region; other site 956149010302 G4 box; other site 956149010303 G5 box; other site 956149010304 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 956149010305 EamA-like transporter family; Region: EamA; pfam00892 956149010306 EamA-like transporter family; Region: EamA; pfam00892 956149010307 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 956149010308 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 956149010309 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 956149010310 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 956149010311 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 956149010312 substrate binding pocket [chemical binding]; other site 956149010313 chain length determination region; other site 956149010314 substrate-Mg2+ binding site; other site 956149010315 catalytic residues [active] 956149010316 aspartate-rich region 1; other site 956149010317 active site lid residues [active] 956149010318 aspartate-rich region 2; other site 956149010319 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 956149010320 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 956149010321 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 956149010322 hinge; other site 956149010323 active site 956149010324 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 956149010325 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 956149010326 anti sigma factor interaction site; other site 956149010327 regulatory phosphorylation site [posttranslational modification]; other site 956149010328 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 956149010329 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 956149010330 mce related protein; Region: MCE; pfam02470 956149010331 conserved hypothetical integral membrane protein; Region: TIGR00056 956149010332 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 956149010333 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 956149010334 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 956149010335 Walker A/P-loop; other site 956149010336 ATP binding site [chemical binding]; other site 956149010337 Q-loop/lid; other site 956149010338 ABC transporter signature motif; other site 956149010339 Walker B; other site 956149010340 D-loop; other site 956149010341 H-loop/switch region; other site 956149010342 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 956149010343 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 956149010344 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 956149010345 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 956149010346 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 956149010347 putative active site [active] 956149010348 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 956149010349 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 956149010350 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 956149010351 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 956149010352 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 956149010353 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 956149010354 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 956149010355 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 956149010356 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 956149010357 Walker A/P-loop; other site 956149010358 ATP binding site [chemical binding]; other site 956149010359 Q-loop/lid; other site 956149010360 ABC transporter signature motif; other site 956149010361 Walker B; other site 956149010362 D-loop; other site 956149010363 H-loop/switch region; other site 956149010364 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 956149010365 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 956149010366 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 956149010367 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 956149010368 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 956149010369 30S subunit binding site; other site 956149010370 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 956149010371 active site 956149010372 phosphorylation site [posttranslational modification] 956149010373 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 956149010374 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 956149010375 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 956149010376 dimerization domain swap beta strand [polypeptide binding]; other site 956149010377 regulatory protein interface [polypeptide binding]; other site 956149010378 active site 956149010379 regulatory phosphorylation site [posttranslational modification]; other site 956149010380 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 956149010381 Transglycosylase; Region: Transgly; cl17702 956149010382 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 956149010383 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 956149010384 conserved cys residue [active] 956149010385 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 956149010386 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 956149010387 putative active site [active] 956149010388 heme pocket [chemical binding]; other site 956149010389 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 956149010390 dimer interface [polypeptide binding]; other site 956149010391 phosphorylation site [posttranslational modification] 956149010392 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 956149010393 ATP binding site [chemical binding]; other site 956149010394 Mg2+ binding site [ion binding]; other site 956149010395 G-X-G motif; other site 956149010396 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 956149010397 active site 956149010398 phosphorylation site [posttranslational modification] 956149010399 intermolecular recognition site; other site 956149010400 dimerization interface [polypeptide binding]; other site 956149010401 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 956149010402 putative binding surface; other site 956149010403 active site 956149010404 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 956149010405 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 956149010406 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 956149010407 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 956149010408 active site 956149010409 dimer interface [polypeptide binding]; other site 956149010410 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 956149010411 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 956149010412 active site 956149010413 FMN binding site [chemical binding]; other site 956149010414 substrate binding site [chemical binding]; other site 956149010415 3Fe-4S cluster binding site [ion binding]; other site 956149010416 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 956149010417 domain interface; other site 956149010418 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 956149010419 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 956149010420 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 956149010421 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 956149010422 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 956149010423 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 956149010424 Autotransporter beta-domain; Region: Autotransporter; smart00869 956149010425 Domain of unknown function (DUF386); Region: DUF386; cl01047 956149010426 N-acetylmannosamine kinase; Provisional; Region: PRK05082 956149010427 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 956149010428 nucleotide binding site [chemical binding]; other site 956149010429 putative sialic acid transporter; Provisional; Region: PRK03893 956149010430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149010431 putative substrate translocation pore; other site 956149010432 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 956149010433 N-acetylneuraminate lyase; Provisional; Region: PRK04147 956149010434 inhibitor site; inhibition site 956149010435 active site 956149010436 dimer interface [polypeptide binding]; other site 956149010437 catalytic residue [active] 956149010438 transcriptional regulator NanR; Provisional; Region: PRK03837 956149010439 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 956149010440 DNA-binding site [nucleotide binding]; DNA binding site 956149010441 FCD domain; Region: FCD; pfam07729 956149010442 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 956149010443 stringent starvation protein A; Provisional; Region: sspA; PRK09481 956149010444 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 956149010445 C-terminal domain interface [polypeptide binding]; other site 956149010446 putative GSH binding site (G-site) [chemical binding]; other site 956149010447 dimer interface [polypeptide binding]; other site 956149010448 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 956149010449 dimer interface [polypeptide binding]; other site 956149010450 N-terminal domain interface [polypeptide binding]; other site 956149010451 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 956149010452 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 956149010453 23S rRNA interface [nucleotide binding]; other site 956149010454 L3 interface [polypeptide binding]; other site 956149010455 Predicted ATPase [General function prediction only]; Region: COG1485 956149010456 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 956149010457 hypothetical protein; Provisional; Region: PRK11677 956149010458 serine endoprotease; Provisional; Region: PRK10139 956149010459 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 956149010460 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 956149010461 protein binding site [polypeptide binding]; other site 956149010462 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 956149010463 serine endoprotease; Provisional; Region: PRK10898 956149010464 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 956149010465 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 956149010466 protein binding site [polypeptide binding]; other site 956149010467 malate dehydrogenase; Provisional; Region: PRK05086 956149010468 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 956149010469 NAD binding site [chemical binding]; other site 956149010470 dimerization interface [polypeptide binding]; other site 956149010471 Substrate binding site [chemical binding]; other site 956149010472 arginine repressor; Provisional; Region: PRK05066 956149010473 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 956149010474 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 956149010475 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 956149010476 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 956149010477 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 956149010478 RNAase interaction site [polypeptide binding]; other site 956149010479 succinic semialdehyde dehydrogenase; Region: PLN02278 956149010480 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 956149010481 tetramerization interface [polypeptide binding]; other site 956149010482 NAD(P) binding site [chemical binding]; other site 956149010483 catalytic residues [active] 956149010484 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 956149010485 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 956149010486 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 956149010487 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 956149010488 HlyD family secretion protein; Region: HlyD_3; pfam13437 956149010489 efflux system membrane protein; Provisional; Region: PRK11594 956149010490 transcriptional regulator; Provisional; Region: PRK10632 956149010491 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149010492 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 956149010493 putative effector binding pocket; other site 956149010494 dimerization interface [polypeptide binding]; other site 956149010495 protease TldD; Provisional; Region: tldD; PRK10735 956149010496 hypothetical protein; Provisional; Region: PRK10899 956149010497 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 956149010498 ribonuclease G; Provisional; Region: PRK11712 956149010499 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 956149010500 homodimer interface [polypeptide binding]; other site 956149010501 oligonucleotide binding site [chemical binding]; other site 956149010502 Maf-like protein; Region: Maf; pfam02545 956149010503 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 956149010504 active site 956149010505 dimer interface [polypeptide binding]; other site 956149010506 rod shape-determining protein MreD; Provisional; Region: PRK11060 956149010507 rod shape-determining protein MreC; Region: mreC; TIGR00219 956149010508 rod shape-determining protein MreC; Region: MreC; pfam04085 956149010509 rod shape-determining protein MreB; Provisional; Region: PRK13927 956149010510 MreB and similar proteins; Region: MreB_like; cd10225 956149010511 nucleotide binding site [chemical binding]; other site 956149010512 Mg binding site [ion binding]; other site 956149010513 putative protofilament interaction site [polypeptide binding]; other site 956149010514 RodZ interaction site [polypeptide binding]; other site 956149010515 regulatory protein CsrD; Provisional; Region: PRK11059 956149010516 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 956149010517 metal binding site [ion binding]; metal-binding site 956149010518 active site 956149010519 I-site; other site 956149010520 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 956149010521 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 956149010522 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 956149010523 NADP binding site [chemical binding]; other site 956149010524 dimer interface [polypeptide binding]; other site 956149010525 TMAO/DMSO reductase; Reviewed; Region: PRK05363 956149010526 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 956149010527 Moco binding site; other site 956149010528 metal coordination site [ion binding]; other site 956149010529 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 956149010530 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 956149010531 Dehydroquinase class II; Region: DHquinase_II; pfam01220 956149010532 active site 956149010533 trimer interface [polypeptide binding]; other site 956149010534 dimer interface [polypeptide binding]; other site 956149010535 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 956149010536 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 956149010537 carboxyltransferase (CT) interaction site; other site 956149010538 biotinylation site [posttranslational modification]; other site 956149010539 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 956149010540 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 956149010541 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 956149010542 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 956149010543 hypothetical protein; Provisional; Region: PRK10633 956149010544 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 956149010545 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 956149010546 Na binding site [ion binding]; other site 956149010547 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 956149010548 Methyltransferase domain; Region: Methyltransf_18; pfam12847 956149010549 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 956149010550 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 956149010551 FMN binding site [chemical binding]; other site 956149010552 active site 956149010553 catalytic residues [active] 956149010554 substrate binding site [chemical binding]; other site 956149010555 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 956149010556 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 956149010557 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 956149010558 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 956149010559 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 956149010560 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 956149010561 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 956149010562 metal binding site [ion binding]; metal-binding site 956149010563 active site 956149010564 I-site; other site 956149010565 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 956149010566 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 956149010567 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 956149010568 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 956149010569 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 956149010570 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 956149010571 HlyD family secretion protein; Region: HlyD_3; pfam13437 956149010572 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 956149010573 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 956149010574 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 956149010575 substrate binding pocket [chemical binding]; other site 956149010576 membrane-bound complex binding site; other site 956149010577 hinge residues; other site 956149010578 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 956149010579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149010580 conserved gate region; other site 956149010581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149010582 putative PBP binding loops; other site 956149010583 dimer interface [polypeptide binding]; other site 956149010584 ABC-ATPase subunit interface; other site 956149010585 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149010586 dimer interface [polypeptide binding]; other site 956149010587 conserved gate region; other site 956149010588 putative PBP binding loops; other site 956149010589 ABC-ATPase subunit interface; other site 956149010590 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 956149010591 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 956149010592 Walker A/P-loop; other site 956149010593 ATP binding site [chemical binding]; other site 956149010594 Q-loop/lid; other site 956149010595 ABC transporter signature motif; other site 956149010596 Walker B; other site 956149010597 D-loop; other site 956149010598 H-loop/switch region; other site 956149010599 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 956149010600 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 956149010601 purine monophosphate binding site [chemical binding]; other site 956149010602 dimer interface [polypeptide binding]; other site 956149010603 putative catalytic residues [active] 956149010604 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 956149010605 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 956149010606 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 956149010607 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 956149010608 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 956149010609 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 956149010610 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 956149010611 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 956149010612 IHF dimer interface [polypeptide binding]; other site 956149010613 IHF - DNA interface [nucleotide binding]; other site 956149010614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 956149010615 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 956149010616 Active_site [active] 956149010617 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 956149010618 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 956149010619 substrate binding site [chemical binding]; other site 956149010620 active site 956149010621 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 956149010622 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 956149010623 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 956149010624 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 956149010625 putative NADH binding site [chemical binding]; other site 956149010626 putative active site [active] 956149010627 nudix motif; other site 956149010628 putative metal binding site [ion binding]; other site 956149010629 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 956149010630 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 956149010631 ThiC-associated domain; Region: ThiC-associated; pfam13667 956149010632 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 956149010633 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 956149010634 thiamine phosphate binding site [chemical binding]; other site 956149010635 active site 956149010636 pyrophosphate binding site [ion binding]; other site 956149010637 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 956149010638 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 956149010639 ATP binding site [chemical binding]; other site 956149010640 substrate interface [chemical binding]; other site 956149010641 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 956149010642 thiS-thiF/thiG interaction site; other site 956149010643 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 956149010644 ThiS interaction site; other site 956149010645 putative active site [active] 956149010646 tetramer interface [polypeptide binding]; other site 956149010647 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 956149010648 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 956149010649 FeS/SAM binding site; other site 956149010650 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 956149010651 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 956149010652 active site 956149010653 P-loop; other site 956149010654 phosphorylation site [posttranslational modification] 956149010655 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 956149010656 methionine cluster; other site 956149010657 active site 956149010658 phosphorylation site [posttranslational modification] 956149010659 metal binding site [ion binding]; metal-binding site 956149010660 Helix-turn-helix domain; Region: HTH_18; pfam12833 956149010661 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 956149010662 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 956149010663 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 956149010664 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 956149010665 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 956149010666 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 956149010667 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 956149010668 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 956149010669 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 956149010670 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 956149010671 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 956149010672 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 956149010673 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 956149010674 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 956149010675 DNA binding site [nucleotide binding] 956149010676 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 956149010677 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 956149010678 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 956149010679 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 956149010680 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 956149010681 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 956149010682 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 956149010683 RPB3 interaction site [polypeptide binding]; other site 956149010684 RPB1 interaction site [polypeptide binding]; other site 956149010685 RPB11 interaction site [polypeptide binding]; other site 956149010686 RPB10 interaction site [polypeptide binding]; other site 956149010687 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 956149010688 core dimer interface [polypeptide binding]; other site 956149010689 peripheral dimer interface [polypeptide binding]; other site 956149010690 L10 interface [polypeptide binding]; other site 956149010691 L11 interface [polypeptide binding]; other site 956149010692 putative EF-Tu interaction site [polypeptide binding]; other site 956149010693 putative EF-G interaction site [polypeptide binding]; other site 956149010694 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 956149010695 23S rRNA interface [nucleotide binding]; other site 956149010696 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 956149010697 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 956149010698 mRNA/rRNA interface [nucleotide binding]; other site 956149010699 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 956149010700 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 956149010701 23S rRNA interface [nucleotide binding]; other site 956149010702 L7/L12 interface [polypeptide binding]; other site 956149010703 putative thiostrepton binding site; other site 956149010704 L25 interface [polypeptide binding]; other site 956149010705 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 956149010706 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 956149010707 putative homodimer interface [polypeptide binding]; other site 956149010708 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 956149010709 heterodimer interface [polypeptide binding]; other site 956149010710 homodimer interface [polypeptide binding]; other site 956149010711 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 956149010712 elongation factor Tu; Reviewed; Region: PRK00049 956149010713 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 956149010714 G1 box; other site 956149010715 GEF interaction site [polypeptide binding]; other site 956149010716 GTP/Mg2+ binding site [chemical binding]; other site 956149010717 Switch I region; other site 956149010718 G2 box; other site 956149010719 G3 box; other site 956149010720 Switch II region; other site 956149010721 G4 box; other site 956149010722 G5 box; other site 956149010723 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 956149010724 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 956149010725 Antibiotic Binding Site [chemical binding]; other site 956149010726 pantothenate kinase; Provisional; Region: PRK05439 956149010727 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 956149010728 ATP-binding site [chemical binding]; other site 956149010729 CoA-binding site [chemical binding]; other site 956149010730 Mg2+-binding site [ion binding]; other site 956149010731 Biotin operon repressor [Transcription]; Region: BirA; COG1654 956149010732 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 956149010733 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 956149010734 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 956149010735 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 956149010736 FAD binding domain; Region: FAD_binding_4; pfam01565 956149010737 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 956149010738 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 956149010739 potassium transporter; Provisional; Region: PRK10750 956149010740 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 956149010741 hypothetical protein; Provisional; Region: PRK11568 956149010742 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 956149010743 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 956149010744 proline dipeptidase; Provisional; Region: PRK13607 956149010745 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 956149010746 active site 956149010747 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 956149010748 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 956149010749 substrate binding site [chemical binding]; other site 956149010750 oxyanion hole (OAH) forming residues; other site 956149010751 trimer interface [polypeptide binding]; other site 956149010752 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 956149010753 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 956149010754 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 956149010755 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 956149010756 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 956149010757 dimer interface [polypeptide binding]; other site 956149010758 active site 956149010759 FMN reductase; Validated; Region: fre; PRK08051 956149010760 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 956149010761 FAD binding pocket [chemical binding]; other site 956149010762 FAD binding motif [chemical binding]; other site 956149010763 phosphate binding motif [ion binding]; other site 956149010764 beta-alpha-beta structure motif; other site 956149010765 NAD binding pocket [chemical binding]; other site 956149010766 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 956149010767 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 956149010768 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 956149010769 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 956149010770 active site 956149010771 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 956149010772 sec-independent translocase; Provisional; Region: PRK01770 956149010773 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 956149010774 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 956149010775 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 956149010776 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 956149010777 SCP-2 sterol transfer family; Region: SCP2; pfam02036 956149010778 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 956149010779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 956149010780 S-adenosylmethionine binding site [chemical binding]; other site 956149010781 DNA recombination protein RmuC; Provisional; Region: PRK10361 956149010782 RmuC family; Region: RmuC; pfam02646 956149010783 uridine phosphorylase; Provisional; Region: PRK11178 956149010784 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 956149010785 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 956149010786 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 956149010787 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 956149010788 THF binding site; other site 956149010789 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 956149010790 substrate binding site [chemical binding]; other site 956149010791 THF binding site; other site 956149010792 zinc-binding site [ion binding]; other site 956149010793 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 956149010794 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149010795 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 956149010796 putative dimerization interface [polypeptide binding]; other site 956149010797 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 956149010798 EamA-like transporter family; Region: EamA; pfam00892 956149010799 putative hydrolase; Provisional; Region: PRK10976 956149010800 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 956149010801 active site 956149010802 motif I; other site 956149010803 motif II; other site 956149010804 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 956149010805 lysophospholipase L2; Provisional; Region: PRK10749 956149010806 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 956149010807 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 956149010808 threonine efflux system; Provisional; Region: PRK10229 956149010809 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 956149010810 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 956149010811 ATP binding site [chemical binding]; other site 956149010812 putative Mg++ binding site [ion binding]; other site 956149010813 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 956149010814 nucleotide binding region [chemical binding]; other site 956149010815 ATP-binding site [chemical binding]; other site 956149010816 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 956149010817 HRDC domain; Region: HRDC; pfam00570 956149010818 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 956149010819 dimerization interface [polypeptide binding]; other site 956149010820 substrate binding site [chemical binding]; other site 956149010821 active site 956149010822 calcium binding site [ion binding]; other site 956149010823 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 956149010824 CoenzymeA binding site [chemical binding]; other site 956149010825 subunit interaction site [polypeptide binding]; other site 956149010826 PHB binding site; other site 956149010827 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 956149010828 EamA-like transporter family; Region: EamA; cl17759 956149010829 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 956149010830 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 956149010831 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 956149010832 Cl binding site [ion binding]; other site 956149010833 oligomer interface [polypeptide binding]; other site 956149010834 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 956149010835 Part of AAA domain; Region: AAA_19; pfam13245 956149010836 Family description; Region: UvrD_C_2; pfam13538 956149010837 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 956149010838 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 956149010839 motif II; other site 956149010840 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 956149010841 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 956149010842 active site 956149010843 Int/Topo IB signature motif; other site 956149010844 hypothetical protein; Provisional; Region: PRK10963 956149010845 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 956149010846 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 956149010847 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 956149010848 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 956149010849 hypothetical protein; Provisional; Region: PRK09807 956149010850 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 956149010851 putative iron binding site [ion binding]; other site 956149010852 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 956149010853 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 956149010854 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 956149010855 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 956149010856 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 956149010857 domain interfaces; other site 956149010858 active site 956149010859 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 956149010860 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 956149010861 active site 956149010862 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 956149010863 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 956149010864 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 956149010865 HemY protein N-terminus; Region: HemY_N; pfam07219 956149010866 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 956149010867 TPR motif; other site 956149010868 binding surface 956149010869 putative transport protein YifK; Provisional; Region: PRK10746 956149010870 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 956149010871 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 956149010872 putative common antigen polymerase; Provisional; Region: PRK02975 956149010873 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 956149010874 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 956149010875 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 956149010876 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 956149010877 inhibitor-cofactor binding pocket; inhibition site 956149010878 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149010879 catalytic residue [active] 956149010880 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 956149010881 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 956149010882 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 956149010883 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 956149010884 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 956149010885 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 956149010886 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 956149010887 active site 956149010888 homodimer interface [polypeptide binding]; other site 956149010889 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 956149010890 Chain length determinant protein; Region: Wzz; pfam02706 956149010891 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 956149010892 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 956149010893 Mg++ binding site [ion binding]; other site 956149010894 putative catalytic motif [active] 956149010895 substrate binding site [chemical binding]; other site 956149010896 transcription termination factor Rho; Provisional; Region: rho; PRK09376 956149010897 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 956149010898 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 956149010899 RNA binding site [nucleotide binding]; other site 956149010900 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 956149010901 multimer interface [polypeptide binding]; other site 956149010902 Walker A motif; other site 956149010903 ATP binding site [chemical binding]; other site 956149010904 Walker B motif; other site 956149010905 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 956149010906 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 956149010907 catalytic residues [active] 956149010908 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 956149010909 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 956149010910 ATP binding site [chemical binding]; other site 956149010911 Mg++ binding site [ion binding]; other site 956149010912 motif III; other site 956149010913 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 956149010914 nucleotide binding region [chemical binding]; other site 956149010915 ATP-binding site [chemical binding]; other site 956149010916 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 956149010917 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 956149010918 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 956149010919 Part of AAA domain; Region: AAA_19; pfam13245 956149010920 Family description; Region: UvrD_C_2; pfam13538 956149010921 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 956149010922 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 956149010923 ketol-acid reductoisomerase; Validated; Region: PRK05225 956149010924 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 956149010925 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 956149010926 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 956149010927 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149010928 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 956149010929 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 956149010930 putative dimerization interface [polypeptide binding]; other site 956149010931 threonine dehydratase; Reviewed; Region: PRK09224 956149010932 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 956149010933 tetramer interface [polypeptide binding]; other site 956149010934 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149010935 catalytic residue [active] 956149010936 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 956149010937 putative Ile/Val binding site [chemical binding]; other site 956149010938 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 956149010939 putative Ile/Val binding site [chemical binding]; other site 956149010940 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 956149010941 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 956149010942 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 956149010943 homodimer interface [polypeptide binding]; other site 956149010944 substrate-cofactor binding pocket; other site 956149010945 catalytic residue [active] 956149010946 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 956149010947 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 956149010948 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 956149010949 PYR/PP interface [polypeptide binding]; other site 956149010950 dimer interface [polypeptide binding]; other site 956149010951 TPP binding site [chemical binding]; other site 956149010952 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 956149010953 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 956149010954 TPP-binding site [chemical binding]; other site 956149010955 dimer interface [polypeptide binding]; other site 956149010956 putative ATP-dependent protease; Provisional; Region: PRK09862 956149010957 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 956149010958 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 956149010959 Walker A motif; other site 956149010960 ATP binding site [chemical binding]; other site 956149010961 Walker B motif; other site 956149010962 arginine finger; other site 956149010963 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 956149010964 hypothetical protein; Provisional; Region: PRK11027 956149010965 transcriptional regulator HdfR; Provisional; Region: PRK03601 956149010966 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149010967 LysR substrate binding domain; Region: LysR_substrate; pfam03466 956149010968 dimerization interface [polypeptide binding]; other site 956149010969 glutamate racemase; Provisional; Region: PRK00865 956149010970 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 956149010971 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 956149010972 N-terminal plug; other site 956149010973 ligand-binding site [chemical binding]; other site 956149010974 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 956149010975 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 956149010976 S-adenosylmethionine binding site [chemical binding]; other site 956149010977 hypothetical protein; Provisional; Region: PRK11056 956149010978 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 956149010979 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 956149010980 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 956149010981 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 956149010982 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 956149010983 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 956149010984 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149010985 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 956149010986 dimerization interface [polypeptide binding]; other site 956149010987 argininosuccinate lyase; Provisional; Region: PRK04833 956149010988 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 956149010989 active sites [active] 956149010990 tetramer interface [polypeptide binding]; other site 956149010991 argininosuccinate synthase; Provisional; Region: PRK13820 956149010992 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 956149010993 ANP binding site [chemical binding]; other site 956149010994 Substrate Binding Site II [chemical binding]; other site 956149010995 Substrate Binding Site I [chemical binding]; other site 956149010996 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 956149010997 nucleotide binding site [chemical binding]; other site 956149010998 N-acetyl-L-glutamate binding site [chemical binding]; other site 956149010999 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 956149011000 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 956149011001 acetylornithine deacetylase; Provisional; Region: PRK05111 956149011002 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 956149011003 metal binding site [ion binding]; metal-binding site 956149011004 putative dimer interface [polypeptide binding]; other site 956149011005 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 956149011006 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 956149011007 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 956149011008 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 956149011009 PapC N-terminal domain; Region: PapC_N; pfam13954 956149011010 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 956149011011 PapC C-terminal domain; Region: PapC_C; pfam13953 956149011012 putative chaperone protein EcpD; Provisional; Region: PRK09926 956149011013 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 956149011014 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 956149011015 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 956149011016 malate:quinone oxidoreductase; Validated; Region: PRK05257 956149011017 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 956149011018 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 956149011019 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 956149011020 putative active site [active] 956149011021 heme pocket [chemical binding]; other site 956149011022 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 956149011023 putative active site [active] 956149011024 heme pocket [chemical binding]; other site 956149011025 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 956149011026 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 956149011027 dimer interface [polypeptide binding]; other site 956149011028 putative CheW interface [polypeptide binding]; other site 956149011029 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 956149011030 FAD binding site [chemical binding]; other site 956149011031 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 956149011032 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 956149011033 putative catalytic residues [active] 956149011034 putative nucleotide binding site [chemical binding]; other site 956149011035 putative aspartate binding site [chemical binding]; other site 956149011036 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 956149011037 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 956149011038 cystathionine gamma-synthase; Provisional; Region: PRK08045 956149011039 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 956149011040 homodimer interface [polypeptide binding]; other site 956149011041 substrate-cofactor binding pocket; other site 956149011042 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149011043 catalytic residue [active] 956149011044 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 956149011045 dimerization interface [polypeptide binding]; other site 956149011046 DNA binding site [nucleotide binding] 956149011047 corepressor binding sites; other site 956149011048 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 956149011049 primosome assembly protein PriA; Validated; Region: PRK05580 956149011050 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 956149011051 ATP binding site [chemical binding]; other site 956149011052 putative Mg++ binding site [ion binding]; other site 956149011053 helicase superfamily c-terminal domain; Region: HELICc; smart00490 956149011054 ATP-binding site [chemical binding]; other site 956149011055 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 956149011056 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 956149011057 DNA binding site [nucleotide binding] 956149011058 domain linker motif; other site 956149011059 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 956149011060 dimerization interface [polypeptide binding]; other site 956149011061 ligand binding site [chemical binding]; other site 956149011062 Sporulation related domain; Region: SPOR; cl10051 956149011063 cell division protein FtsN; Provisional; Region: PRK12757 956149011064 cell division protein FtsN; Provisional; Region: PRK12757 956149011065 Sporulation related domain; Region: SPOR; cl10051 956149011066 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 956149011067 active site 956149011068 HslU subunit interaction site [polypeptide binding]; other site 956149011069 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 956149011070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 956149011071 Walker A motif; other site 956149011072 ATP binding site [chemical binding]; other site 956149011073 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 956149011074 Walker B motif; other site 956149011075 arginine finger; other site 956149011076 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 956149011077 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 956149011078 UbiA prenyltransferase family; Region: UbiA; pfam01040 956149011079 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 956149011080 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3074 956149011081 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 956149011082 amphipathic channel; other site 956149011083 Asn-Pro-Ala signature motifs; other site 956149011084 glycerol kinase; Provisional; Region: glpK; PRK00047 956149011085 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 956149011086 N- and C-terminal domain interface [polypeptide binding]; other site 956149011087 active site 956149011088 MgATP binding site [chemical binding]; other site 956149011089 catalytic site [active] 956149011090 metal binding site [ion binding]; metal-binding site 956149011091 glycerol binding site [chemical binding]; other site 956149011092 homotetramer interface [polypeptide binding]; other site 956149011093 homodimer interface [polypeptide binding]; other site 956149011094 FBP binding site [chemical binding]; other site 956149011095 protein IIAGlc interface [polypeptide binding]; other site 956149011096 hypothetical protein; Provisional; Region: PRK11020 956149011097 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 956149011098 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 956149011099 non-specific DNA binding site [nucleotide binding]; other site 956149011100 salt bridge; other site 956149011101 sequence-specific DNA binding site [nucleotide binding]; other site 956149011102 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 956149011103 L-lactate permease; Provisional; Region: PRK10420 956149011104 glycolate transporter; Provisional; Region: PRK09695 956149011105 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 956149011106 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 956149011107 DNA-binding site [nucleotide binding]; DNA binding site 956149011108 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 956149011109 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 956149011110 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 956149011111 active site 956149011112 substrate binding site [chemical binding]; other site 956149011113 FMN binding site [chemical binding]; other site 956149011114 putative catalytic residues [active] 956149011115 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 956149011116 MOSC domain; Region: MOSC; pfam03473 956149011117 3-alpha domain; Region: 3-alpha; pfam03475 956149011118 superoxide dismutase; Provisional; Region: PRK10925 956149011119 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 956149011120 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 956149011121 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 956149011122 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 956149011123 transcriptional activator RhaR; Provisional; Region: PRK13502 956149011124 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 956149011125 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 956149011126 transcriptional activator RhaS; Provisional; Region: PRK13503 956149011127 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 956149011128 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 956149011129 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 956149011130 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 956149011131 N- and C-terminal domain interface [polypeptide binding]; other site 956149011132 active site 956149011133 putative catalytic site [active] 956149011134 metal binding site [ion binding]; metal-binding site 956149011135 ATP binding site [chemical binding]; other site 956149011136 rhamnulokinase; Provisional; Region: rhaB; PRK10640 956149011137 carbohydrate binding site [chemical binding]; other site 956149011138 L-rhamnose isomerase; Provisional; Region: PRK01076 956149011139 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 956149011140 intersubunit interface [polypeptide binding]; other site 956149011141 active site 956149011142 Zn2+ binding site [ion binding]; other site 956149011143 lactaldehyde reductase; Region: lactal_redase; TIGR02638 956149011144 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 956149011145 dimer interface [polypeptide binding]; other site 956149011146 active site 956149011147 metal binding site [ion binding]; metal-binding site 956149011148 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 956149011149 galactoside permease; Reviewed; Region: lacY; PRK09528 956149011150 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149011151 putative substrate translocation pore; other site 956149011152 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 956149011153 Melibiase; Region: Melibiase; pfam02065 956149011154 Transcriptional regulators [Transcription]; Region: PurR; COG1609 956149011155 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 956149011156 DNA binding site [nucleotide binding] 956149011157 domain linker motif; other site 956149011158 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 956149011159 ligand binding site [chemical binding]; other site 956149011160 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 956149011161 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 956149011162 non-specific DNA binding site [nucleotide binding]; other site 956149011163 salt bridge; other site 956149011164 sequence-specific DNA binding site [nucleotide binding]; other site 956149011165 Cupin domain; Region: Cupin_2; cl17218 956149011166 AzlC protein; Region: AzlC; cl00570 956149011167 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 956149011168 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 956149011169 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 956149011170 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 956149011171 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 956149011172 molybdopterin cofactor binding site; other site 956149011173 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 956149011174 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 956149011175 molybdopterin cofactor binding site; other site 956149011176 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 956149011177 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 956149011178 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 956149011179 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 956149011180 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 956149011181 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 956149011182 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 956149011183 oligomeric interface; other site 956149011184 putative active site [active] 956149011185 homodimer interface [polypeptide binding]; other site 956149011186 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 956149011187 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 956149011188 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 956149011189 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 956149011190 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 956149011191 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 956149011192 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 956149011193 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 956149011194 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 956149011195 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 956149011196 nucleotide binding site [chemical binding]; other site 956149011197 putative alcohol dehydrogenase; Provisional; Region: PRK09860 956149011198 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 956149011199 dimer interface [polypeptide binding]; other site 956149011200 active site 956149011201 metal binding site [ion binding]; metal-binding site 956149011202 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 956149011203 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 956149011204 G1 box; other site 956149011205 putative GEF interaction site [polypeptide binding]; other site 956149011206 GTP/Mg2+ binding site [chemical binding]; other site 956149011207 Switch I region; other site 956149011208 G2 box; other site 956149011209 G3 box; other site 956149011210 Switch II region; other site 956149011211 G4 box; other site 956149011212 G5 box; other site 956149011213 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 956149011214 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 956149011215 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 956149011216 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 956149011217 selenocysteine synthase; Provisional; Region: PRK04311 956149011218 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 956149011219 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 956149011220 putative glutathione S-transferase; Provisional; Region: PRK10357 956149011221 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 956149011222 putative C-terminal domain interface [polypeptide binding]; other site 956149011223 putative GSH binding site (G-site) [chemical binding]; other site 956149011224 putative dimer interface [polypeptide binding]; other site 956149011225 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 956149011226 dimer interface [polypeptide binding]; other site 956149011227 N-terminal domain interface [polypeptide binding]; other site 956149011228 putative substrate binding pocket (H-site) [chemical binding]; other site 956149011229 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 956149011230 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 956149011231 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 956149011232 active site 956149011233 P-loop; other site 956149011234 phosphorylation site [posttranslational modification] 956149011235 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 956149011236 active site 956149011237 phosphorylation site [posttranslational modification] 956149011238 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 956149011239 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 956149011240 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 956149011241 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 956149011242 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 956149011243 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 956149011244 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 956149011245 putative active site [active] 956149011246 ferredoxin-NADP reductase; Provisional; Region: PRK10926 956149011247 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 956149011248 FAD binding pocket [chemical binding]; other site 956149011249 FAD binding motif [chemical binding]; other site 956149011250 phosphate binding motif [ion binding]; other site 956149011251 beta-alpha-beta structure motif; other site 956149011252 NAD binding pocket [chemical binding]; other site 956149011253 Predicted membrane protein [Function unknown]; Region: COG3152 956149011254 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 956149011255 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 956149011256 triosephosphate isomerase; Provisional; Region: PRK14567 956149011257 substrate binding site [chemical binding]; other site 956149011258 dimer interface [polypeptide binding]; other site 956149011259 catalytic triad [active] 956149011260 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 956149011261 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 956149011262 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 956149011263 RHS protein; Region: RHS; pfam03527 956149011264 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 956149011265 RHS protein; Region: RHS; pfam03527 956149011266 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 956149011267 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 956149011268 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 956149011269 PAAR motif; Region: PAAR_motif; pfam05488 956149011270 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 956149011271 RHS Repeat; Region: RHS_repeat; cl11982 956149011272 RHS Repeat; Region: RHS_repeat; pfam05593 956149011273 RHS Repeat; Region: RHS_repeat; cl11982 956149011274 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 956149011275 RHS Repeat; Region: RHS_repeat; pfam05593 956149011276 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 956149011277 RHS protein; Region: RHS; pfam03527 956149011278 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 956149011279 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 956149011280 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 956149011281 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 956149011282 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 956149011283 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 956149011284 RHS Repeat; Region: RHS_repeat; pfam05593 956149011285 RHS Repeat; Region: RHS_repeat; pfam05593 956149011286 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 956149011287 RHS Repeat; Region: RHS_repeat; pfam05593 956149011288 RHS Repeat; Region: RHS_repeat; pfam05593 956149011289 RHS protein; Region: RHS; pfam03527 956149011290 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 956149011291 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 956149011292 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 956149011293 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 956149011294 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 956149011295 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 956149011296 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 956149011297 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 956149011298 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 956149011299 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 956149011300 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 956149011301 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 956149011302 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 956149011303 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 956149011304 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 956149011305 Catalytic domain of Protein Kinases; Region: PKc; cd00180 956149011306 active site 956149011307 ATP binding site [chemical binding]; other site 956149011308 substrate binding site [chemical binding]; other site 956149011309 activation loop (A-loop); other site 956149011310 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 956149011311 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 956149011312 Walker A motif; other site 956149011313 ATP binding site [chemical binding]; other site 956149011314 Walker B motif; other site 956149011315 arginine finger; other site 956149011316 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 956149011317 Walker A motif; other site 956149011318 ATP binding site [chemical binding]; other site 956149011319 Walker B motif; other site 956149011320 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 956149011321 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 956149011322 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 956149011323 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 956149011324 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 956149011325 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 956149011326 ImpE protein; Region: ImpE; pfam07024 956149011327 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 956149011328 active site 956149011329 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 956149011330 phosphopeptide binding site; other site 956149011331 Protein of unknown function (DUF796); Region: DUF796; pfam05638 956149011332 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 956149011333 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 956149011334 Protein of unknown function (DUF877); Region: DUF877; pfam05943 956149011335 Protein of unknown function (DUF770); Region: DUF770; pfam05591 956149011336 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 956149011337 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 956149011338 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 956149011339 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 956149011340 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 956149011341 G1 box; other site 956149011342 GTP/Mg2+ binding site [chemical binding]; other site 956149011343 G2 box; other site 956149011344 Switch I region; other site 956149011345 G3 box; other site 956149011346 Switch II region; other site 956149011347 G4 box; other site 956149011348 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 956149011349 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 956149011350 hypothetical protein; Provisional; Region: PRK07033 956149011351 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 956149011352 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 956149011353 ligand binding site [chemical binding]; other site 956149011354 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 956149011355 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 956149011356 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 956149011357 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 956149011358 Coenzyme A binding pocket [chemical binding]; other site 956149011359 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 956149011360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149011361 putative substrate translocation pore; other site 956149011362 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 956149011363 Domain of unknown function (DUF202); Region: DUF202; cl09954 956149011364 Predicted membrane protein [Function unknown]; Region: COG2149 956149011365 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 956149011366 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 956149011367 NAD binding site [chemical binding]; other site 956149011368 sugar binding site [chemical binding]; other site 956149011369 divalent metal binding site [ion binding]; other site 956149011370 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 956149011371 dimer interface [polypeptide binding]; other site 956149011372 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 956149011373 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 956149011374 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 956149011375 active site turn [active] 956149011376 phosphorylation site [posttranslational modification] 956149011377 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 956149011378 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 956149011379 DNA-binding site [nucleotide binding]; DNA binding site 956149011380 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 956149011381 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 956149011382 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 956149011383 putative dimer interface [polypeptide binding]; other site 956149011384 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 956149011385 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 956149011386 putative dimer interface [polypeptide binding]; other site 956149011387 hypothetical protein; Provisional; Region: PRK11616 956149011388 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 956149011389 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 956149011390 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 956149011391 putative ligand binding site [chemical binding]; other site 956149011392 NAD binding site [chemical binding]; other site 956149011393 catalytic site [active] 956149011394 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 956149011395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149011396 putative substrate translocation pore; other site 956149011397 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149011398 D-galactonate transporter; Region: 2A0114; TIGR00893 956149011399 putative substrate translocation pore; other site 956149011400 galactonate dehydratase; Provisional; Region: PRK14017 956149011401 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 956149011402 putative active site pocket [active] 956149011403 putative metal binding site [ion binding]; other site 956149011404 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 956149011405 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 956149011406 active site 956149011407 intersubunit interface [polypeptide binding]; other site 956149011408 catalytic residue [active] 956149011409 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 956149011410 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 956149011411 Transcriptional regulators [Transcription]; Region: FadR; COG2186 956149011412 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 956149011413 DNA-binding site [nucleotide binding]; DNA binding site 956149011414 FCD domain; Region: FCD; pfam07729 956149011415 modulator of post-segregation killing protein; Provisional; Region: PRK13720 956149011416 sugar phosphate phosphatase; Provisional; Region: PRK10513 956149011417 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 956149011418 active site 956149011419 motif I; other site 956149011420 motif II; other site 956149011421 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 956149011422 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 956149011423 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 956149011424 Mg2+ binding site [ion binding]; other site 956149011425 G-X-G motif; other site 956149011426 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 956149011427 anchoring element; other site 956149011428 dimer interface [polypeptide binding]; other site 956149011429 ATP binding site [chemical binding]; other site 956149011430 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 956149011431 active site 956149011432 putative metal-binding site [ion binding]; other site 956149011433 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 956149011434 recF protein; Region: recf; TIGR00611 956149011435 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 956149011436 Walker A/P-loop; other site 956149011437 ATP binding site [chemical binding]; other site 956149011438 Q-loop/lid; other site 956149011439 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 956149011440 ABC transporter signature motif; other site 956149011441 Walker B; other site 956149011442 D-loop; other site 956149011443 H-loop/switch region; other site 956149011444 DNA polymerase III subunit beta; Validated; Region: PRK05643 956149011445 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 956149011446 putative DNA binding surface [nucleotide binding]; other site 956149011447 dimer interface [polypeptide binding]; other site 956149011448 beta-clamp/clamp loader binding surface; other site 956149011449 beta-clamp/translesion DNA polymerase binding surface; other site 956149011450 DnaA N-terminal domain; Region: DnaA_N; pfam11638 956149011451 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 956149011452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 956149011453 Walker A motif; other site 956149011454 ATP binding site [chemical binding]; other site 956149011455 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 956149011456 Walker B motif; other site 956149011457 arginine finger; other site 956149011458 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 956149011459 DnaA box-binding interface [nucleotide binding]; other site 956149011460 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 956149011461 ribonuclease P; Reviewed; Region: rnpA; PRK01732 956149011462 hypothetical protein; Validated; Region: PRK00041 956149011463 membrane protein insertase; Provisional; Region: PRK01318 956149011464 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 956149011465 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 956149011466 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 956149011467 trmE is a tRNA modification GTPase; Region: trmE; cd04164 956149011468 G1 box; other site 956149011469 GTP/Mg2+ binding site [chemical binding]; other site 956149011470 Switch I region; other site 956149011471 G2 box; other site 956149011472 Switch II region; other site 956149011473 G3 box; other site 956149011474 G4 box; other site 956149011475 G5 box; other site 956149011476 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 956149011477 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 956149011478 active site 956149011479 DNA binding site [nucleotide binding] 956149011480 Int/Topo IB signature motif; other site 956149011481 trigger factor; Region: tig; TIGR00115 956149011482 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 956149011483 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 956149011484 active site residue [active] 956149011485 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 956149011486 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 956149011487 ligand binding site [chemical binding]; other site 956149011488 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 956149011489 AzlC protein; Region: AzlC; cl00570 956149011490 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 956149011491 Coenzyme A binding pocket [chemical binding]; other site 956149011492 Biofilm formation and stress response factor; Region: BsmA; pfam10014 956149011493 Transcriptional regulator [Transcription]; Region: LysR; COG0583 956149011494 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149011495 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 956149011496 Predicted flavoprotein [General function prediction only]; Region: COG0431 956149011497 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 956149011498 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 956149011499 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 956149011500 Phage stabilisation protein; Region: Phage_stabilise; pfam11134 956149011501 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 956149011502 motif II; other site 956149011503 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 956149011504 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 956149011505 transcriptional regulator PhoU; Provisional; Region: PRK11115 956149011506 PhoU domain; Region: PhoU; pfam01895 956149011507 PhoU domain; Region: PhoU; pfam01895 956149011508 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 956149011509 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 956149011510 Walker A/P-loop; other site 956149011511 ATP binding site [chemical binding]; other site 956149011512 Q-loop/lid; other site 956149011513 ABC transporter signature motif; other site 956149011514 Walker B; other site 956149011515 D-loop; other site 956149011516 H-loop/switch region; other site 956149011517 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 956149011518 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149011519 dimer interface [polypeptide binding]; other site 956149011520 conserved gate region; other site 956149011521 putative PBP binding loops; other site 956149011522 ABC-ATPase subunit interface; other site 956149011523 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 956149011524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149011525 dimer interface [polypeptide binding]; other site 956149011526 conserved gate region; other site 956149011527 putative PBP binding loops; other site 956149011528 ABC-ATPase subunit interface; other site 956149011529 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 956149011530 substrate binding pocket [chemical binding]; other site 956149011531 membrane-bound complex binding site; other site 956149011532 hinge residues; other site 956149011533 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 956149011534 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 956149011535 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 956149011536 glutaminase active site [active] 956149011537 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 956149011538 dimer interface [polypeptide binding]; other site 956149011539 active site 956149011540 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 956149011541 dimer interface [polypeptide binding]; other site 956149011542 active site 956149011543 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 956149011544 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 956149011545 Substrate binding site; other site 956149011546 Mg++ binding site; other site 956149011547 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 956149011548 active site 956149011549 substrate binding site [chemical binding]; other site 956149011550 CoA binding site [chemical binding]; other site 956149011551 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 956149011552 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 956149011553 gamma subunit interface [polypeptide binding]; other site 956149011554 epsilon subunit interface [polypeptide binding]; other site 956149011555 LBP interface [polypeptide binding]; other site 956149011556 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 956149011557 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 956149011558 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 956149011559 alpha subunit interaction interface [polypeptide binding]; other site 956149011560 Walker A motif; other site 956149011561 ATP binding site [chemical binding]; other site 956149011562 Walker B motif; other site 956149011563 inhibitor binding site; inhibition site 956149011564 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 956149011565 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 956149011566 core domain interface [polypeptide binding]; other site 956149011567 delta subunit interface [polypeptide binding]; other site 956149011568 epsilon subunit interface [polypeptide binding]; other site 956149011569 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 956149011570 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 956149011571 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 956149011572 beta subunit interaction interface [polypeptide binding]; other site 956149011573 Walker A motif; other site 956149011574 ATP binding site [chemical binding]; other site 956149011575 Walker B motif; other site 956149011576 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 956149011577 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 956149011578 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 956149011579 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 956149011580 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 956149011581 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 956149011582 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 956149011583 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 956149011584 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 956149011585 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 956149011586 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 956149011587 S-adenosylmethionine binding site [chemical binding]; other site 956149011588 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 956149011589 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 956149011590 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 956149011591 FMN-binding protein MioC; Provisional; Region: PRK09004 956149011592 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 956149011593 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 956149011594 putative DNA binding site [nucleotide binding]; other site 956149011595 putative Zn2+ binding site [ion binding]; other site 956149011596 AsnC family; Region: AsnC_trans_reg; pfam01037 956149011597 Asparagine synthetase A [Amino acid transport and metabolism]; Region: AsnA; COG2502 956149011598 motif 1; other site 956149011599 dimer interface [polypeptide binding]; other site 956149011600 active site 956149011601 motif 2; other site 956149011602 motif 3; other site 956149011603 hypothetical protein; Provisional; Region: yieM; PRK10997 956149011604 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 956149011605 metal ion-dependent adhesion site (MIDAS); other site 956149011606 regulatory ATPase RavA; Provisional; Region: PRK13531 956149011607 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 956149011608 Walker A motif; other site 956149011609 ATP binding site [chemical binding]; other site 956149011610 Walker B motif; other site 956149011611 arginine finger; other site 956149011612 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 956149011613 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 956149011614 potassium uptake protein; Region: kup; TIGR00794 956149011615 D-ribose pyranase; Provisional; Region: PRK11797 956149011616 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 956149011617 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 956149011618 Walker A/P-loop; other site 956149011619 ATP binding site [chemical binding]; other site 956149011620 Q-loop/lid; other site 956149011621 ABC transporter signature motif; other site 956149011622 Walker B; other site 956149011623 D-loop; other site 956149011624 H-loop/switch region; other site 956149011625 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 956149011626 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 956149011627 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 956149011628 TM-ABC transporter signature motif; other site 956149011629 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 956149011630 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 956149011631 ligand binding site [chemical binding]; other site 956149011632 dimerization interface [polypeptide binding]; other site 956149011633 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 956149011634 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 956149011635 substrate binding site [chemical binding]; other site 956149011636 dimer interface [polypeptide binding]; other site 956149011637 ATP binding site [chemical binding]; other site 956149011638 transcriptional repressor RbsR; Provisional; Region: PRK10423 956149011639 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 956149011640 DNA binding site [nucleotide binding] 956149011641 domain linker motif; other site 956149011642 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 956149011643 dimerization interface [polypeptide binding]; other site 956149011644 ligand binding site [chemical binding]; other site 956149011645 putative transporter; Provisional; Region: PRK10504 956149011646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149011647 putative substrate translocation pore; other site 956149011648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149011649 Transcriptional regulators [Transcription]; Region: FadR; COG2186 956149011650 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 956149011651 DNA-binding site [nucleotide binding]; DNA binding site 956149011652 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 956149011653 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 956149011654 Walker A motif; other site 956149011655 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 956149011656 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 956149011657 GTP binding site; other site 956149011658 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 956149011659 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 956149011660 serine/threonine protein kinase; Provisional; Region: PRK11768 956149011661 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 956149011662 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 956149011663 catalytic residues [active] 956149011664 hinge region; other site 956149011665 alpha helical domain; other site 956149011666 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 956149011667 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 956149011668 putative acyl-acceptor binding pocket; other site 956149011669 DNA polymerase I; Provisional; Region: PRK05755 956149011670 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 956149011671 active site 956149011672 metal binding site 1 [ion binding]; metal-binding site 956149011673 putative 5' ssDNA interaction site; other site 956149011674 metal binding site 3; metal-binding site 956149011675 metal binding site 2 [ion binding]; metal-binding site 956149011676 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 956149011677 putative DNA binding site [nucleotide binding]; other site 956149011678 putative metal binding site [ion binding]; other site 956149011679 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 956149011680 active site 956149011681 catalytic site [active] 956149011682 substrate binding site [chemical binding]; other site 956149011683 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 956149011684 active site 956149011685 DNA binding site [nucleotide binding] 956149011686 catalytic site [active] 956149011687 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 956149011688 G1 box; other site 956149011689 GTP/Mg2+ binding site [chemical binding]; other site 956149011690 Switch I region; other site 956149011691 G2 box; other site 956149011692 G3 box; other site 956149011693 Switch II region; other site 956149011694 G4 box; other site 956149011695 G5 box; other site 956149011696 Der GTPase activator; Provisional; Region: PRK05244 956149011697 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 956149011698 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 956149011699 FeS/SAM binding site; other site 956149011700 HemN C-terminal domain; Region: HemN_C; pfam06969 956149011701 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 956149011702 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 956149011703 active site 956149011704 phosphorylation site [posttranslational modification] 956149011705 intermolecular recognition site; other site 956149011706 dimerization interface [polypeptide binding]; other site 956149011707 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 956149011708 Walker A motif; other site 956149011709 ATP binding site [chemical binding]; other site 956149011710 Walker B motif; other site 956149011711 arginine finger; other site 956149011712 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 956149011713 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 956149011714 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 956149011715 putative active site [active] 956149011716 heme pocket [chemical binding]; other site 956149011717 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 956149011718 dimer interface [polypeptide binding]; other site 956149011719 phosphorylation site [posttranslational modification] 956149011720 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 956149011721 ATP binding site [chemical binding]; other site 956149011722 Mg2+ binding site [ion binding]; other site 956149011723 G-X-G motif; other site 956149011724 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 956149011725 glutamine synthetase; Provisional; Region: glnA; PRK09469 956149011726 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 956149011727 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 956149011728 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 956149011729 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 956149011730 G1 box; other site 956149011731 putative GEF interaction site [polypeptide binding]; other site 956149011732 GTP/Mg2+ binding site [chemical binding]; other site 956149011733 Switch I region; other site 956149011734 G2 box; other site 956149011735 G3 box; other site 956149011736 Switch II region; other site 956149011737 G4 box; other site 956149011738 G5 box; other site 956149011739 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 956149011740 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 956149011741 outer membrane porin L; Provisional; Region: ompL; PRK09980 956149011742 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 956149011743 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 956149011744 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 956149011745 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149011746 putative substrate translocation pore; other site 956149011747 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 956149011748 alpha-glucosidase; Provisional; Region: PRK10426 956149011749 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 956149011750 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 956149011751 putative active site [active] 956149011752 putative catalytic site [active] 956149011753 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 956149011754 active site 956149011755 catalytic residues [active] 956149011756 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 956149011757 dimerization interface [polypeptide binding]; other site 956149011758 putative active cleft [active] 956149011759 Class I aldolases; Region: Aldolase_Class_I; cl17187 956149011760 catalytic residue [active] 956149011761 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 956149011762 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 956149011763 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 956149011764 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 956149011765 substrate binding site [chemical binding]; other site 956149011766 ATP binding site [chemical binding]; other site 956149011767 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 956149011768 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 956149011769 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 956149011770 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 956149011771 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 956149011772 motif II; other site 956149011773 hypothetical protein; Reviewed; Region: PRK01637 956149011774 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 956149011775 putative active site [active] 956149011776 dimerization interface [polypeptide binding]; other site 956149011777 putative tRNAtyr binding site [nucleotide binding]; other site 956149011778 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 956149011779 Coenzyme A binding pocket [chemical binding]; other site 956149011780 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 956149011781 AsmA family; Region: AsmA; pfam05170 956149011782 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 956149011783 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 956149011784 Fimbrial protein; Region: Fimbrial; pfam00419 956149011785 Fimbrial protein; Region: Fimbrial; cl01416 956149011786 Fimbrial protein; Region: Fimbrial; pfam00419 956149011787 Fimbrial protein; Region: Fimbrial; pfam00419 956149011788 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 956149011789 PapC N-terminal domain; Region: PapC_N; pfam13954 956149011790 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 956149011791 PapC C-terminal domain; Region: PapC_C; pfam13953 956149011792 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 956149011793 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 956149011794 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 956149011795 Fimbrial protein; Region: Fimbrial; pfam00419 956149011796 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 956149011797 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 956149011798 generic binding surface II; other site 956149011799 ssDNA binding site; other site 956149011800 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 956149011801 ATP binding site [chemical binding]; other site 956149011802 putative Mg++ binding site [ion binding]; other site 956149011803 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 956149011804 nucleotide binding region [chemical binding]; other site 956149011805 ATP-binding site [chemical binding]; other site 956149011806 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 956149011807 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 956149011808 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 956149011809 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 956149011810 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 956149011811 Zn2+ binding site [ion binding]; other site 956149011812 Mg2+ binding site [ion binding]; other site 956149011813 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 956149011814 synthetase active site [active] 956149011815 NTP binding site [chemical binding]; other site 956149011816 metal binding site [ion binding]; metal-binding site 956149011817 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 956149011818 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 956149011819 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 956149011820 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 956149011821 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 956149011822 catalytic site [active] 956149011823 G-X2-G-X-G-K; other site 956149011824 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 956149011825 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 956149011826 nucleotide binding pocket [chemical binding]; other site 956149011827 K-X-D-G motif; other site 956149011828 catalytic site [active] 956149011829 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 956149011830 Predicted membrane protein [Function unknown]; Region: COG2860 956149011831 UPF0126 domain; Region: UPF0126; pfam03458 956149011832 UPF0126 domain; Region: UPF0126; pfam03458 956149011833 hypothetical protein; Provisional; Region: PRK11820 956149011834 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 956149011835 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 956149011836 ribonuclease PH; Reviewed; Region: rph; PRK00173 956149011837 Ribonuclease PH; Region: RNase_PH_bact; cd11362 956149011838 hexamer interface [polypeptide binding]; other site 956149011839 active site 956149011840 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 956149011841 active site 956149011842 division inhibitor protein; Provisional; Region: slmA; PRK09480 956149011843 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 956149011844 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 956149011845 trimer interface [polypeptide binding]; other site 956149011846 active site 956149011847 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 956149011848 Flavoprotein; Region: Flavoprotein; pfam02441 956149011849 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 956149011850 hypothetical protein; Reviewed; Region: PRK00024 956149011851 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 956149011852 MPN+ (JAMM) motif; other site 956149011853 Zinc-binding site [ion binding]; other site 956149011854 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 956149011855 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 956149011856 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 956149011857 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 956149011858 DNA binding site [nucleotide binding] 956149011859 catalytic residue [active] 956149011860 H2TH interface [polypeptide binding]; other site 956149011861 putative catalytic residues [active] 956149011862 turnover-facilitating residue; other site 956149011863 intercalation triad [nucleotide binding]; other site 956149011864 8OG recognition residue [nucleotide binding]; other site 956149011865 putative reading head residues; other site 956149011866 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 956149011867 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 956149011868 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 956149011869 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 956149011870 active site 956149011871 (T/H)XGH motif; other site 956149011872 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 956149011873 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 956149011874 putative metal binding site; other site 956149011875 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 956149011876 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 956149011877 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 956149011878 Sulfatase; Region: Sulfatase; cl17466 956149011879 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 956149011880 putative glycosyl transferase; Provisional; Region: PRK10073 956149011881 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 956149011882 active site 956149011883 O-Antigen ligase; Region: Wzy_C; cl04850 956149011884 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 956149011885 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 956149011886 putative ADP-binding pocket [chemical binding]; other site 956149011887 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 956149011888 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 956149011889 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 956149011890 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 956149011891 putative active site [active] 956149011892 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 956149011893 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 956149011894 putative active site [active] 956149011895 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 956149011896 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 956149011897 putative active site [active] 956149011898 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 956149011899 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 956149011900 NADP binding site [chemical binding]; other site 956149011901 homopentamer interface [polypeptide binding]; other site 956149011902 substrate binding site [chemical binding]; other site 956149011903 active site 956149011904 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 956149011905 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 956149011906 substrate-cofactor binding pocket; other site 956149011907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149011908 catalytic residue [active] 956149011909 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 956149011910 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 956149011911 NAD(P) binding site [chemical binding]; other site 956149011912 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 956149011913 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 956149011914 putative metal binding site; other site 956149011915 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 956149011916 NodB motif; other site 956149011917 putative active site [active] 956149011918 putative catalytic site [active] 956149011919 Zn binding site [ion binding]; other site 956149011920 AmiB activator; Provisional; Region: PRK11637 956149011921 Peptidase family M23; Region: Peptidase_M23; pfam01551 956149011922 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 956149011923 phosphoglyceromutase; Provisional; Region: PRK05434 956149011924 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 956149011925 active site residue [active] 956149011926 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 956149011927 GSH binding site [chemical binding]; other site 956149011928 catalytic residues [active] 956149011929 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 956149011930 SecA binding site; other site 956149011931 Preprotein binding site; other site 956149011932 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 956149011933 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 956149011934 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 956149011935 serine acetyltransferase; Provisional; Region: cysE; PRK11132 956149011936 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 956149011937 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 956149011938 trimer interface [polypeptide binding]; other site 956149011939 active site 956149011940 substrate binding site [chemical binding]; other site 956149011941 CoA binding site [chemical binding]; other site 956149011942 putative rRNA methylase; Provisional; Region: PRK10358 956149011943 two-component sensor protein; Provisional; Region: cpxA; PRK09470 956149011944 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 956149011945 dimerization interface [polypeptide binding]; other site 956149011946 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 956149011947 dimer interface [polypeptide binding]; other site 956149011948 phosphorylation site [posttranslational modification] 956149011949 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 956149011950 ATP binding site [chemical binding]; other site 956149011951 Mg2+ binding site [ion binding]; other site 956149011952 G-X-G motif; other site 956149011953 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 956149011954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 956149011955 active site 956149011956 intermolecular recognition site; other site 956149011957 dimerization interface [polypeptide binding]; other site 956149011958 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 956149011959 DNA binding site [nucleotide binding] 956149011960 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 956149011961 dimer interface [polypeptide binding]; other site 956149011962 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 956149011963 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 956149011964 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 956149011965 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 956149011966 active site 956149011967 ADP/pyrophosphate binding site [chemical binding]; other site 956149011968 dimerization interface [polypeptide binding]; other site 956149011969 allosteric effector site; other site 956149011970 fructose-1,6-bisphosphate binding site; other site 956149011971 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 956149011972 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 956149011973 substrate binding pocket [chemical binding]; other site 956149011974 membrane-bound complex binding site; other site 956149011975 hinge residues; other site 956149011976 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 956149011977 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 956149011978 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 956149011979 transmembrane helices; other site 956149011980 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 956149011981 active site 956149011982 homotetramer interface [polypeptide binding]; other site 956149011983 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 956149011984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 956149011985 active site 956149011986 phosphorylation site [posttranslational modification] 956149011987 intermolecular recognition site; other site 956149011988 dimerization interface [polypeptide binding]; other site 956149011989 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 956149011990 DNA binding site [nucleotide binding] 956149011991 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 956149011992 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 956149011993 dimer interface [polypeptide binding]; other site 956149011994 phosphorylation site [posttranslational modification] 956149011995 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 956149011996 ATP binding site [chemical binding]; other site 956149011997 G-X-G motif; other site 956149011998 CAAX protease self-immunity; Region: Abi; pfam02517 956149011999 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 956149012000 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 956149012001 putative metal binding site; other site 956149012002 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 956149012003 binding surface 956149012004 TPR motif; other site 956149012005 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 956149012006 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 956149012007 catalytic loop [active] 956149012008 iron binding site [ion binding]; other site 956149012009 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 956149012010 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 956149012011 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 956149012012 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 956149012013 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 956149012014 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 956149012015 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 956149012016 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 956149012017 XdhC Rossmann domain; Region: XdhC_C; pfam13478 956149012018 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 956149012019 metal-binding site 956149012020 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 956149012021 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 956149012022 active site 956149012023 catalytic tetrad [active] 956149012024 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 956149012025 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 956149012026 Protein of unknown function (DUF796); Region: DUF796; cl01226 956149012027 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 956149012028 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 956149012029 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 956149012030 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 956149012031 putative alpha-glucosidase; Provisional; Region: PRK10658 956149012032 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 956149012033 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 956149012034 active site 956149012035 homotrimer interface [polypeptide binding]; other site 956149012036 catalytic site [active] 956149012037 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 956149012038 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 956149012039 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 956149012040 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149012041 homodimer interface [polypeptide binding]; other site 956149012042 catalytic residue [active] 956149012043 alpha-amylase; Reviewed; Region: malS; PRK09505 956149012044 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 956149012045 active site 956149012046 catalytic site [active] 956149012047 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 956149012048 hypothetical protein; Provisional; Region: PRK10356 956149012049 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 956149012050 putative dimerization interface [polypeptide binding]; other site 956149012051 Transcriptional regulators [Transcription]; Region: PurR; COG1609 956149012052 putative ligand binding site [chemical binding]; other site 956149012053 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 956149012054 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 956149012055 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 956149012056 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 956149012057 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 956149012058 TM-ABC transporter signature motif; other site 956149012059 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 956149012060 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 956149012061 Walker A/P-loop; other site 956149012062 ATP binding site [chemical binding]; other site 956149012063 Q-loop/lid; other site 956149012064 ABC transporter signature motif; other site 956149012065 Walker B; other site 956149012066 D-loop; other site 956149012067 H-loop/switch region; other site 956149012068 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 956149012069 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 956149012070 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 956149012071 putative ligand binding site [chemical binding]; other site 956149012072 xylose isomerase; Provisional; Region: PRK05474 956149012073 xylose isomerase; Region: xylose_isom_A; TIGR02630 956149012074 xylulokinase; Provisional; Region: PRK15027 956149012075 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 956149012076 N- and C-terminal domain interface [polypeptide binding]; other site 956149012077 active site 956149012078 MgATP binding site [chemical binding]; other site 956149012079 catalytic site [active] 956149012080 metal binding site [ion binding]; metal-binding site 956149012081 xylulose binding site [chemical binding]; other site 956149012082 homodimer interface [polypeptide binding]; other site 956149012083 Isochorismatase family; Region: Isochorismatase; pfam00857 956149012084 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 956149012085 catalytic triad [active] 956149012086 conserved cis-peptide bond; other site 956149012087 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 956149012088 conserved cys residue [active] 956149012089 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 956149012090 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 956149012091 Acyltransferase family; Region: Acyl_transf_3; pfam01757 956149012092 YsaB-like lipoprotein; Region: YsaB; pfam13983 956149012093 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 956149012094 dimer interface [polypeptide binding]; other site 956149012095 motif 1; other site 956149012096 active site 956149012097 motif 2; other site 956149012098 motif 3; other site 956149012099 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 956149012100 DALR anticodon binding domain; Region: DALR_1; pfam05746 956149012101 Hok/gef family; Region: HOK_GEF; pfam01848 956149012102 Predicted transcriptional regulator [Transcription]; Region: COG2944 956149012103 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 956149012104 salt bridge; other site 956149012105 non-specific DNA binding site [nucleotide binding]; other site 956149012106 sequence-specific DNA binding site [nucleotide binding]; other site 956149012107 small toxic polypeptide; Provisional; Region: PRK09738 956149012108 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 956149012109 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 956149012110 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 956149012111 dimerization interface [polypeptide binding]; other site 956149012112 ligand binding site [chemical binding]; other site 956149012113 NADP binding site [chemical binding]; other site 956149012114 catalytic site [active] 956149012115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149012116 D-galactonate transporter; Region: 2A0114; TIGR00893 956149012117 putative substrate translocation pore; other site 956149012118 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 956149012119 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 956149012120 substrate binding site [chemical binding]; other site 956149012121 ATP binding site [chemical binding]; other site 956149012122 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 956149012123 Transcriptional regulators [Transcription]; Region: PurR; COG1609 956149012124 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 956149012125 DNA binding site [nucleotide binding] 956149012126 domain linker motif; other site 956149012127 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 956149012128 putative dimerization interface [polypeptide binding]; other site 956149012129 putative ligand binding site [chemical binding]; other site 956149012130 zinc/cadmium-binding protein; Provisional; Region: PRK10306 956149012131 putative outer membrane lipoprotein; Provisional; Region: PRK10510 956149012132 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 956149012133 ligand binding site [chemical binding]; other site 956149012134 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 956149012135 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 956149012136 molybdopterin cofactor binding site [chemical binding]; other site 956149012137 substrate binding site [chemical binding]; other site 956149012138 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 956149012139 molybdopterin cofactor binding site; other site 956149012140 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 956149012141 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 956149012142 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 956149012143 Coenzyme A binding pocket [chemical binding]; other site 956149012144 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 956149012145 Autotransporter beta-domain; Region: Autotransporter; cl17461 956149012146 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 956149012147 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149012148 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 956149012149 phosphoethanolamine transferase; Provisional; Region: PRK11560 956149012150 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 956149012151 Sulfatase; Region: Sulfatase; pfam00884 956149012152 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 956149012153 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 956149012154 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 956149012155 peptide binding site [polypeptide binding]; other site 956149012156 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 956149012157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149012158 dimer interface [polypeptide binding]; other site 956149012159 conserved gate region; other site 956149012160 putative PBP binding loops; other site 956149012161 ABC-ATPase subunit interface; other site 956149012162 dipeptide transporter; Provisional; Region: PRK10913 956149012163 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 956149012164 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149012165 dimer interface [polypeptide binding]; other site 956149012166 conserved gate region; other site 956149012167 putative PBP binding loops; other site 956149012168 ABC-ATPase subunit interface; other site 956149012169 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 956149012170 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 956149012171 Walker A/P-loop; other site 956149012172 ATP binding site [chemical binding]; other site 956149012173 Q-loop/lid; other site 956149012174 ABC transporter signature motif; other site 956149012175 Walker B; other site 956149012176 D-loop; other site 956149012177 H-loop/switch region; other site 956149012178 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 956149012179 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 956149012180 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 956149012181 Walker A/P-loop; other site 956149012182 ATP binding site [chemical binding]; other site 956149012183 Q-loop/lid; other site 956149012184 ABC transporter signature motif; other site 956149012185 Walker B; other site 956149012186 D-loop; other site 956149012187 H-loop/switch region; other site 956149012188 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 956149012189 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 956149012190 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 956149012191 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 956149012192 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 956149012193 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 956149012194 YhjQ protein; Region: YhjQ; pfam06564 956149012195 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 956149012196 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 956149012197 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 956149012198 DXD motif; other site 956149012199 PilZ domain; Region: PilZ; pfam07238 956149012200 cellulose synthase regulator protein; Provisional; Region: PRK11114 956149012201 endo-1,4-D-glucanase; Provisional; Region: PRK11097 956149012202 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 956149012203 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 956149012204 TPR motif; other site 956149012205 binding surface 956149012206 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 956149012207 putative diguanylate cyclase; Provisional; Region: PRK13561 956149012208 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 956149012209 dimerization interface [polypeptide binding]; other site 956149012210 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 956149012211 metal binding site [ion binding]; metal-binding site 956149012212 active site 956149012213 I-site; other site 956149012214 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 956149012215 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 956149012216 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 956149012217 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 956149012218 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 956149012219 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 956149012220 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 956149012221 substrate binding site [chemical binding]; other site 956149012222 ATP binding site [chemical binding]; other site 956149012223 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 956149012224 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 956149012225 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 956149012226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149012227 metabolite-proton symporter; Region: 2A0106; TIGR00883 956149012228 putative substrate translocation pore; other site 956149012229 inner membrane protein YhjD; Region: TIGR00766 956149012230 Transcriptional regulator [Transcription]; Region: LysR; COG0583 956149012231 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149012232 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 956149012233 putative effector binding pocket; other site 956149012234 putative dimerization interface [polypeptide binding]; other site 956149012235 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 956149012236 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 956149012237 NAD(P) binding site [chemical binding]; other site 956149012238 active site 956149012239 hypothetical protein; Provisional; Region: PRK10053 956149012240 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 956149012241 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 956149012242 glutathione reductase; Validated; Region: PRK06116 956149012243 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 956149012244 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 956149012245 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 956149012246 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 956149012247 oligopeptidase A; Provisional; Region: PRK10911 956149012248 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 956149012249 active site 956149012250 Zn binding site [ion binding]; other site 956149012251 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 956149012252 S-adenosylmethionine binding site [chemical binding]; other site 956149012253 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 956149012254 Ligand Binding Site [chemical binding]; other site 956149012255 universal stress protein UspB; Provisional; Region: PRK04960 956149012256 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 956149012257 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 956149012258 Predicted flavoproteins [General function prediction only]; Region: COG2081 956149012259 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 956149012260 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 956149012261 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 956149012262 NlpC/P60 family; Region: NLPC_P60; pfam00877 956149012263 Domain of unknown function DUF20; Region: UPF0118; pfam01594 956149012264 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 956149012265 major facilitator superfamily transporter; Provisional; Region: PRK05122 956149012266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149012267 putative substrate translocation pore; other site 956149012268 hypothetical protein; Provisional; Region: PRK11615 956149012269 hypothetical protein; Provisional; Region: PRK11212 956149012270 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 956149012271 CPxP motif; other site 956149012272 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 956149012273 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 956149012274 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 956149012275 potential frameshift: common BLAST hit: gi|389839203|ref|YP_006341287.1| TRAP transporter, DctM subunit 956149012276 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 956149012277 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 956149012278 metal-binding site [ion binding] 956149012279 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 956149012280 Predicted membrane protein [Function unknown]; Region: COG3714 956149012281 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 956149012282 hypothetical protein; Provisional; Region: PRK10910 956149012283 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 956149012284 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 956149012285 S-adenosylmethionine binding site [chemical binding]; other site 956149012286 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 956149012287 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 956149012288 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 956149012289 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 956149012290 P loop; other site 956149012291 GTP binding site [chemical binding]; other site 956149012292 cell division protein FtsE; Provisional; Region: PRK10908 956149012293 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 956149012294 Walker A/P-loop; other site 956149012295 ATP binding site [chemical binding]; other site 956149012296 Q-loop/lid; other site 956149012297 ABC transporter signature motif; other site 956149012298 Walker B; other site 956149012299 D-loop; other site 956149012300 H-loop/switch region; other site 956149012301 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 956149012302 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 956149012303 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 956149012304 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 956149012305 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 956149012306 DNA binding residues [nucleotide binding] 956149012307 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 956149012308 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 956149012309 DNA-binding site [nucleotide binding]; DNA binding site 956149012310 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 956149012311 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149012312 homodimer interface [polypeptide binding]; other site 956149012313 catalytic residue [active] 956149012314 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 956149012315 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 956149012316 inhibitor-cofactor binding pocket; inhibition site 956149012317 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149012318 catalytic residue [active] 956149012319 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 956149012320 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 956149012321 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 956149012322 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 956149012323 dimerization interface [polypeptide binding]; other site 956149012324 ligand binding site [chemical binding]; other site 956149012325 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 956149012326 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 956149012327 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 956149012328 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 956149012329 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 956149012330 TM-ABC transporter signature motif; other site 956149012331 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 956149012332 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 956149012333 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 956149012334 TM-ABC transporter signature motif; other site 956149012335 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 956149012336 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 956149012337 Walker A/P-loop; other site 956149012338 ATP binding site [chemical binding]; other site 956149012339 Q-loop/lid; other site 956149012340 ABC transporter signature motif; other site 956149012341 Walker B; other site 956149012342 D-loop; other site 956149012343 H-loop/switch region; other site 956149012344 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 956149012345 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 956149012346 Walker A/P-loop; other site 956149012347 ATP binding site [chemical binding]; other site 956149012348 Q-loop/lid; other site 956149012349 ABC transporter signature motif; other site 956149012350 Walker B; other site 956149012351 D-loop; other site 956149012352 H-loop/switch region; other site 956149012353 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 956149012354 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 956149012355 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149012356 dimer interface [polypeptide binding]; other site 956149012357 conserved gate region; other site 956149012358 putative PBP binding loops; other site 956149012359 ABC-ATPase subunit interface; other site 956149012360 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 956149012361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 956149012362 dimer interface [polypeptide binding]; other site 956149012363 conserved gate region; other site 956149012364 putative PBP binding loops; other site 956149012365 ABC-ATPase subunit interface; other site 956149012366 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 956149012367 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 956149012368 Walker A/P-loop; other site 956149012369 ATP binding site [chemical binding]; other site 956149012370 Q-loop/lid; other site 956149012371 ABC transporter signature motif; other site 956149012372 Walker B; other site 956149012373 D-loop; other site 956149012374 H-loop/switch region; other site 956149012375 TOBE domain; Region: TOBE_2; pfam08402 956149012376 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 956149012377 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 956149012378 putative active site [active] 956149012379 catalytic site [active] 956149012380 putative metal binding site [ion binding]; other site 956149012381 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 956149012382 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 956149012383 putative acetyltransferase YhhY; Provisional; Region: PRK10140 956149012384 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 956149012385 Coenzyme A binding pocket [chemical binding]; other site 956149012386 putative oxidoreductase; Provisional; Region: PRK10206 956149012387 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 956149012388 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 956149012389 Pirin-related protein [General function prediction only]; Region: COG1741 956149012390 Pirin; Region: Pirin; pfam02678 956149012391 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 956149012392 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 956149012393 DNA binding site [nucleotide binding] 956149012394 domain linker motif; other site 956149012395 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 956149012396 putative ligand binding site [chemical binding]; other site 956149012397 putative dimerization interface [polypeptide binding]; other site 956149012398 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 956149012399 ATP-binding site [chemical binding]; other site 956149012400 Gluconate-6-phosphate binding site [chemical binding]; other site 956149012401 low affinity gluconate transporter; Provisional; Region: PRK10472 956149012402 gluconate transporter; Region: gntP; TIGR00791 956149012403 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 956149012404 Fic/DOC family; Region: Fic; pfam02661 956149012405 putative antibiotic transporter; Provisional; Region: PRK10739 956149012406 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 956149012407 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 956149012408 glycogen branching enzyme; Provisional; Region: PRK05402 956149012409 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 956149012410 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 956149012411 active site 956149012412 catalytic site [active] 956149012413 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 956149012414 glycogen debranching enzyme; Provisional; Region: PRK03705 956149012415 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 956149012416 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 956149012417 active site 956149012418 catalytic site [active] 956149012419 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 956149012420 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 956149012421 ligand binding site; other site 956149012422 oligomer interface; other site 956149012423 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 956149012424 dimer interface [polypeptide binding]; other site 956149012425 N-terminal domain interface [polypeptide binding]; other site 956149012426 sulfate 1 binding site; other site 956149012427 glycogen synthase; Provisional; Region: glgA; PRK00654 956149012428 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 956149012429 ADP-binding pocket [chemical binding]; other site 956149012430 homodimer interface [polypeptide binding]; other site 956149012431 glycogen phosphorylase; Provisional; Region: PRK14986 956149012432 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 956149012433 homodimer interface [polypeptide binding]; other site 956149012434 active site pocket [active] 956149012435 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 956149012436 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 956149012437 metal binding site [ion binding]; metal-binding site 956149012438 active site 956149012439 I-site; other site 956149012440 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 956149012441 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 956149012442 active site residue [active] 956149012443 intramembrane serine protease GlpG; Provisional; Region: PRK10907 956149012444 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 956149012445 Rhomboid family; Region: Rhomboid; cl11446 956149012446 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 956149012447 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 956149012448 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 956149012449 transcriptional regulator MalT; Provisional; Region: PRK04841 956149012450 AAA ATPase domain; Region: AAA_16; pfam13191 956149012451 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 956149012452 DNA binding residues [nucleotide binding] 956149012453 dimerization interface [polypeptide binding]; other site 956149012454 maltodextrin phosphorylase; Provisional; Region: PRK14985 956149012455 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 956149012456 active site pocket [active] 956149012457 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 956149012458 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 956149012459 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 956149012460 DNA-binding site [nucleotide binding]; DNA binding site 956149012461 RNA-binding motif; other site 956149012462 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 956149012463 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 956149012464 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 956149012465 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 956149012466 active site 956149012467 carboxylesterase BioH; Provisional; Region: PRK10349 956149012468 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 956149012469 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 956149012470 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 956149012471 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 956149012472 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 956149012473 G1 box; other site 956149012474 GTP/Mg2+ binding site [chemical binding]; other site 956149012475 Switch I region; other site 956149012476 G2 box; other site 956149012477 G3 box; other site 956149012478 Switch II region; other site 956149012479 G4 box; other site 956149012480 G5 box; other site 956149012481 Nucleoside recognition; Region: Gate; pfam07670 956149012482 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 956149012483 Nucleoside recognition; Region: Gate; pfam07670 956149012484 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 956149012485 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 956149012486 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 956149012487 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 956149012488 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 956149012489 RNA binding site [nucleotide binding]; other site 956149012490 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 956149012491 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 956149012492 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 956149012493 osmolarity response regulator; Provisional; Region: ompR; PRK09468 956149012494 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 956149012495 active site 956149012496 phosphorylation site [posttranslational modification] 956149012497 intermolecular recognition site; other site 956149012498 dimerization interface [polypeptide binding]; other site 956149012499 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 956149012500 DNA binding site [nucleotide binding] 956149012501 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 956149012502 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 956149012503 dimerization interface [polypeptide binding]; other site 956149012504 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 956149012505 dimer interface [polypeptide binding]; other site 956149012506 phosphorylation site [posttranslational modification] 956149012507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 956149012508 ATP binding site [chemical binding]; other site 956149012509 G-X-G motif; other site 956149012510 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 956149012511 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 956149012512 active site 956149012513 substrate-binding site [chemical binding]; other site 956149012514 metal-binding site [ion binding] 956149012515 ATP binding site [chemical binding]; other site 956149012516 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 956149012517 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 956149012518 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 956149012519 dimerization interface [polypeptide binding]; other site 956149012520 domain crossover interface; other site 956149012521 redox-dependent activation switch; other site 956149012522 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 956149012523 RNA binding surface [nucleotide binding]; other site 956149012524 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 956149012525 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 956149012526 motif II; other site 956149012527 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 956149012528 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 956149012529 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 956149012530 ADP-ribose binding site [chemical binding]; other site 956149012531 dimer interface [polypeptide binding]; other site 956149012532 active site 956149012533 nudix motif; other site 956149012534 metal binding site [ion binding]; metal-binding site 956149012535 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 956149012536 Transglycosylase; Region: Transgly; pfam00912 956149012537 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 956149012538 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 956149012539 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 956149012540 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 956149012541 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 956149012542 shikimate kinase; Reviewed; Region: aroK; PRK00131 956149012543 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 956149012544 ADP binding site [chemical binding]; other site 956149012545 magnesium binding site [ion binding]; other site 956149012546 putative shikimate binding site; other site 956149012547 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 956149012548 active site 956149012549 dimer interface [polypeptide binding]; other site 956149012550 metal binding site [ion binding]; metal-binding site 956149012551 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 956149012552 cell division protein DamX; Validated; Region: PRK10905 956149012553 DNA adenine methylase; Provisional; Region: PRK10904 956149012554 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 956149012555 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 956149012556 substrate binding site [chemical binding]; other site 956149012557 hexamer interface [polypeptide binding]; other site 956149012558 metal binding site [ion binding]; metal-binding site 956149012559 phosphoglycolate phosphatase; Provisional; Region: PRK13222 956149012560 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 956149012561 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 956149012562 motif II; other site 956149012563 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 956149012564 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 956149012565 active site 956149012566 HIGH motif; other site 956149012567 dimer interface [polypeptide binding]; other site 956149012568 KMSKS motif; other site 956149012569 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 956149012570 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 956149012571 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 956149012572 DNA-binding site [nucleotide binding]; DNA binding site 956149012573 UTRA domain; Region: UTRA; pfam07702 956149012574 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 956149012575 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 956149012576 substrate binding site [chemical binding]; other site 956149012577 ATP binding site [chemical binding]; other site 956149012578 fructoselysine 3-epimerase; Provisional; Region: PRK09856 956149012579 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 956149012580 AP (apurinic/apyrimidinic) site pocket; other site 956149012581 DNA interaction; other site 956149012582 Metal-binding active site; metal-binding site 956149012583 fructoselysine-6-P-deglycase; Provisional; Region: frlB; PRK11382 956149012584 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 956149012585 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 956149012586 dimer interface [polypeptide binding]; other site 956149012587 active site 956149012588 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 956149012589 hypothetical protein; Provisional; Region: PHA02764 956149012590 siroheme synthase; Provisional; Region: cysG; PRK10637 956149012591 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 956149012592 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 956149012593 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 956149012594 active site 956149012595 SAM binding site [chemical binding]; other site 956149012596 homodimer interface [polypeptide binding]; other site 956149012597 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 956149012598 nitrite reductase subunit NirD; Provisional; Region: PRK14989 956149012599 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 956149012600 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 956149012601 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 956149012602 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 956149012603 putative transporter; Provisional; Region: PRK03699 956149012604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149012605 putative substrate translocation pore; other site 956149012606 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 956149012607 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 956149012608 substrate binding site [chemical binding]; other site 956149012609 Protein of unknown function (DUF2559); Region: DUF2559; pfam10832 956149012610 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 956149012611 cell filamentation protein Fic; Provisional; Region: PRK10347 956149012612 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 956149012613 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 956149012614 glutamine binding [chemical binding]; other site 956149012615 catalytic triad [active] 956149012616 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 956149012617 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 956149012618 inhibitor-cofactor binding pocket; inhibition site 956149012619 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149012620 catalytic residue [active] 956149012621 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 956149012622 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 956149012623 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 956149012624 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 956149012625 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 956149012626 ligand binding site [chemical binding]; other site 956149012627 flexible hinge region; other site 956149012628 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 956149012629 putative switch regulator; other site 956149012630 non-specific DNA interactions [nucleotide binding]; other site 956149012631 DNA binding site [nucleotide binding] 956149012632 sequence specific DNA binding site [nucleotide binding]; other site 956149012633 putative cAMP binding site [chemical binding]; other site 956149012634 hypothetical protein; Provisional; Region: PRK10738 956149012635 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 956149012636 active site 956149012637 hypothetical protein; Provisional; Region: PRK04966 956149012638 putative hydrolase; Provisional; Region: PRK10985 956149012639 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 956149012640 nudix motif; other site 956149012641 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 956149012642 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 956149012643 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 956149012644 active site 956149012645 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 956149012646 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 956149012647 active site 956149012648 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 956149012649 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 956149012650 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 956149012651 Walker A/P-loop; other site 956149012652 ATP binding site [chemical binding]; other site 956149012653 Q-loop/lid; other site 956149012654 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 956149012655 ABC transporter signature motif; other site 956149012656 Walker B; other site 956149012657 D-loop; other site 956149012658 ABC transporter; Region: ABC_tran_2; pfam12848 956149012659 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 956149012660 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 956149012661 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 956149012662 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 956149012663 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 956149012664 TrkA-N domain; Region: TrkA_N; pfam02254 956149012665 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 956149012666 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 956149012667 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 956149012668 SlyX; Region: SlyX; pfam04102 956149012669 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 956149012670 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 956149012671 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 956149012672 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 956149012673 YheO-like PAS domain; Region: PAS_6; pfam08348 956149012674 HTH domain; Region: HTH_22; pfam13309 956149012675 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 956149012676 sulfur relay protein TusC; Validated; Region: PRK00211 956149012677 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 956149012678 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 956149012679 S17 interaction site [polypeptide binding]; other site 956149012680 S8 interaction site; other site 956149012681 16S rRNA interaction site [nucleotide binding]; other site 956149012682 streptomycin interaction site [chemical binding]; other site 956149012683 23S rRNA interaction site [nucleotide binding]; other site 956149012684 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 956149012685 30S ribosomal protein S7; Validated; Region: PRK05302 956149012686 elongation factor G; Reviewed; Region: PRK00007 956149012687 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 956149012688 G1 box; other site 956149012689 putative GEF interaction site [polypeptide binding]; other site 956149012690 GTP/Mg2+ binding site [chemical binding]; other site 956149012691 Switch I region; other site 956149012692 G2 box; other site 956149012693 G3 box; other site 956149012694 Switch II region; other site 956149012695 G4 box; other site 956149012696 G5 box; other site 956149012697 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 956149012698 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 956149012699 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 956149012700 elongation factor Tu; Reviewed; Region: PRK00049 956149012701 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 956149012702 G1 box; other site 956149012703 GEF interaction site [polypeptide binding]; other site 956149012704 GTP/Mg2+ binding site [chemical binding]; other site 956149012705 Switch I region; other site 956149012706 G2 box; other site 956149012707 G3 box; other site 956149012708 Switch II region; other site 956149012709 G4 box; other site 956149012710 G5 box; other site 956149012711 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 956149012712 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 956149012713 Antibiotic Binding Site [chemical binding]; other site 956149012714 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 956149012715 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 956149012716 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 956149012717 heme binding site [chemical binding]; other site 956149012718 ferroxidase pore; other site 956149012719 ferroxidase diiron center [ion binding]; other site 956149012720 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 956149012721 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 956149012722 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 956149012723 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 956149012724 dimerization interface [polypeptide binding]; other site 956149012725 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 956149012726 dimer interface [polypeptide binding]; other site 956149012727 phosphorylation site [posttranslational modification] 956149012728 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 956149012729 ATP binding site [chemical binding]; other site 956149012730 Mg2+ binding site [ion binding]; other site 956149012731 G-X-G motif; other site 956149012732 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 956149012733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 956149012734 active site 956149012735 phosphorylation site [posttranslational modification] 956149012736 intermolecular recognition site; other site 956149012737 dimerization interface [polypeptide binding]; other site 956149012738 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 956149012739 DNA binding site [nucleotide binding] 956149012740 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 956149012741 CopC domain; Region: CopC; pfam04234 956149012742 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 956149012743 Multicopper oxidase; Region: Cu-oxidase; pfam00394 956149012744 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 956149012745 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 956149012746 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 956149012747 Peptidase family M23; Region: Peptidase_M23; pfam01551 956149012748 potential frameshift: common BLAST hit: gi|380083277|ref|YP_005351292.1| cation transporting P-type ATPase 956149012749 Protein of unknown function, DUF; Region: DUF411; cl01142 956149012750 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 956149012751 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 956149012752 HlyD family secretion protein; Region: HlyD_3; pfam13437 956149012753 periplasmic copper-binding protein; Provisional; Region: PRK09838 956149012754 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 956149012755 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 956149012756 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 956149012757 active site 956149012758 phosphorylation site [posttranslational modification] 956149012759 intermolecular recognition site; other site 956149012760 dimerization interface [polypeptide binding]; other site 956149012761 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 956149012762 DNA binding site [nucleotide binding] 956149012763 sensor kinase CusS; Provisional; Region: PRK09835 956149012764 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 956149012765 dimerization interface [polypeptide binding]; other site 956149012766 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 956149012767 dimer interface [polypeptide binding]; other site 956149012768 phosphorylation site [posttranslational modification] 956149012769 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 956149012770 ATP binding site [chemical binding]; other site 956149012771 Mg2+ binding site [ion binding]; other site 956149012772 G-X-G motif; other site 956149012773 Domain of unknown function (DUF305); Region: DUF305; cl17794 956149012774 potential frameshift: common BLAST hit: gi|410651558|ref|YP_006954680.1| putative HNH endonuclease 956149012775 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 956149012776 GAF domain; Region: GAF; pfam01590 956149012777 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 956149012778 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 956149012779 metal binding site [ion binding]; metal-binding site 956149012780 active site 956149012781 I-site; other site 956149012782 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 956149012783 NTP binding site [chemical binding]; other site 956149012784 Phage integrase family; Region: Phage_integrase; pfam00589 956149012785 active site 956149012786 DNA binding site [nucleotide binding] 956149012787 Int/Topo IB signature motif; other site 956149012788 ParG; Region: ParG; pfam09274 956149012789 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 956149012790 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 956149012791 P-loop; other site 956149012792 Magnesium ion binding site [ion binding]; other site 956149012793 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 956149012794 putative dimer interface [polypeptide binding]; other site 956149012795 N-terminal domain interface [polypeptide binding]; other site 956149012796 putative substrate binding pocket (H-site) [chemical binding]; other site 956149012797 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 956149012798 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 956149012799 oligomeric interface; other site 956149012800 putative active site [active] 956149012801 homodimer interface [polypeptide binding]; other site 956149012802 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 956149012803 modulator of post-segregation killing protein; Provisional; Region: PRK13720 956149012804 small toxic polypeptide; Provisional; Region: PRK09738 956149012805 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 956149012806 elongation factor Tu; Reviewed; Region: PRK12736 956149012807 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 956149012808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149012809 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 956149012810 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 956149012811 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 956149012812 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 956149012813 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 956149012814 MbeB-like, N-term conserved region; Region: MbeB_N; pfam04837 956149012815 MbeD/MobD like; Region: MbeD_MobD; pfam04899 956149012816 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 956149012817 catalytic core [active] 956149012818 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 956149012819 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 956149012820 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 956149012821 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 956149012822 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 956149012823 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 956149012824 Major Facilitator Superfamily; Region: MFS_1; pfam07690 956149012825 outer membrane protease; Reviewed; Region: PRK10993 956149012826 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 956149012827 HTH domain; Region: HTH_11; pfam08279 956149012828 Predicted transcriptional regulator [Transcription]; Region: COG2378 956149012829 WYL domain; Region: WYL; pfam13280 956149012830 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 956149012831 putative dimer interface [polypeptide binding]; other site 956149012832 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 956149012833 antimicrobial resistance protein Mig-14; Provisional; Region: PRK15312 956149012834 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 956149012835 MltA-interacting protein MipA; Region: MipA; cl01504 956149012836 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 956149012837 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 956149012838 active site 956149012839 phosphorylation site [posttranslational modification] 956149012840 intermolecular recognition site; other site 956149012841 dimerization interface [polypeptide binding]; other site 956149012842 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 956149012843 DNA binding site [nucleotide binding] 956149012844 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 956149012845 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 956149012846 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 956149012847 dimer interface [polypeptide binding]; other site 956149012848 phosphorylation site [posttranslational modification] 956149012849 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 956149012850 ATP binding site [chemical binding]; other site 956149012851 Mg2+ binding site [ion binding]; other site 956149012852 G-X-G motif; other site 956149012853 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 956149012854 HlyD family secretion protein; Region: HlyD_3; pfam13437 956149012855 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 956149012856 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 956149012857 nudix motif; other site 956149012858 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 956149012859 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 956149012860 Coenzyme A binding pocket [chemical binding]; other site 956149012861 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 956149012862 ABC transporter transmembrane region; Region: ABC_membrane_3; pfam13748 956149012863 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 956149012864 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 956149012865 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 956149012866 citrate-proton symporter; Provisional; Region: PRK15075 956149012867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149012868 putative substrate translocation pore; other site 956149012869 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 956149012870 Transcriptional regulator [Transcription]; Region: LysR; COG0583 956149012871 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 956149012872 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 956149012873 putative dimerization interface [polypeptide binding]; other site 956149012874 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 956149012875 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 956149012876 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 956149012877 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 956149012878 active site 956149012879 metal binding site [ion binding]; metal-binding site 956149012880 hexamer interface [polypeptide binding]; other site 956149012881 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 956149012882 Sensors of blue-light using FAD; Region: BLUF; smart01034 956149012883 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 956149012884 transcriptional regulator MirA; Provisional; Region: PRK15043 956149012885 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 956149012886 DNA binding residues [nucleotide binding] 956149012887 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 956149012888 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 956149012889 dimerization interface [polypeptide binding]; other site 956149012890 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 956149012891 dimer interface [polypeptide binding]; other site 956149012892 putative CheW interface [polypeptide binding]; other site 956149012893 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 956149012894 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 956149012895 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 956149012896 Coenzyme A binding pocket [chemical binding]; other site 956149012897 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 956149012898 ACT domain-containing protein [General function prediction only]; Region: COG4747 956149012899 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 956149012900 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 956149012901 dimerization interface [polypeptide binding]; other site 956149012902 putative DNA binding site [nucleotide binding]; other site 956149012903 putative Zn2+ binding site [ion binding]; other site 956149012904 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 956149012905 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 956149012906 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 956149012907 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 956149012908 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 956149012909 active site turn [active] 956149012910 phosphorylation site [posttranslational modification] 956149012911 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 956149012912 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 956149012913 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 956149012914 metal binding site [ion binding]; metal-binding site 956149012915 substrate binding pocket [chemical binding]; other site 956149012916 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 956149012917 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 956149012918 DNA-binding site [nucleotide binding]; DNA binding site 956149012919 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 956149012920 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 956149012921 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 956149012922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 956149012923 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 956149012924 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 956149012925 metal binding site [ion binding]; metal-binding site 956149012926 active site 956149012927 I-site; other site 956149012928 Protein of unknown function (DUF796); Region: DUF796; pfam05638 956149012929 Cation transport protein; Region: TrkH; cl17365 956149012930 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 956149012931 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 956149012932 ArsC family; Region: ArsC; pfam03960 956149012933 catalytic residues [active] 956149012934 arsenical pump membrane protein; Provisional; Region: PRK15445 956149012935 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 956149012936 transmembrane helices; other site 956149012937 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 956149012938 putative DNA binding site [nucleotide binding]; other site 956149012939 putative Zn2+ binding site [ion binding]; other site 956149012940 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 956149012941 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 956149012942 inhibitor site; inhibition site 956149012943 active site 956149012944 dimer interface [polypeptide binding]; other site 956149012945 catalytic residue [active] 956149012946 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 956149012947 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 956149012948 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 956149012949 DNA-binding site [nucleotide binding]; DNA binding site 956149012950 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 956149012951 pyridoxal 5'-phosphate binding site [chemical binding]; other site 956149012952 homodimer interface [polypeptide binding]; other site 956149012953 catalytic residue [active] 956149012954 potential frameshift: common BLAST hit: gi|389841198|ref|YP_006343282.1| type VI secretion protein 956149012955 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 956149012956 Protein of unknown function (DUF877); Region: DUF877; pfam05943 956149012957 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 956149012958 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 956149012959 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 956149012960 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 956149012961 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 956149012962 dimerization domain [polypeptide binding]; other site 956149012963 dimer interface [polypeptide binding]; other site 956149012964 catalytic residues [active] 956149012965 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 956149012966 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 956149012967 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 956149012968 DsbD alpha interface [polypeptide binding]; other site 956149012969 catalytic residues [active] 956149012970 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 956149012971 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 956149012972 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 956149012973 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 956149012974 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 956149012975 Walker A/P-loop; other site 956149012976 ATP binding site [chemical binding]; other site 956149012977 Q-loop/lid; other site 956149012978 ABC transporter signature motif; other site 956149012979 Walker B; other site 956149012980 D-loop; other site 956149012981 H-loop/switch region; other site 956149012982 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 956149012983 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 956149012984 ABC-ATPase subunit interface; other site 956149012985 dimer interface [polypeptide binding]; other site 956149012986 putative PBP binding regions; other site 956149012987 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 956149012988 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 956149012989 intersubunit interface [polypeptide binding]; other site 956149012990 Major Facilitator Superfamily; Region: MFS_1; pfam07690 956149012991 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149012992 putative substrate translocation pore; other site 956149012993 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 956149012994 active site 956149012995 DNA binding site [nucleotide binding] 956149012996 Int/Topo IB signature motif; other site 956149012997 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 956149012998 putative homodimer interface [polypeptide binding]; other site 956149012999 putative active site [active] 956149013000 catalytic site [active] 956149013001 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 956149013002 putative Mg++ binding site [ion binding]; other site 956149013003 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 956149013004 ATP-binding site [chemical binding]; other site 956149013005 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 956149013006 C factor cell-cell signaling protein; Provisional; Region: PRK09009 956149013007 NAD(P) binding site [chemical binding]; other site 956149013008 active site 956149013009 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 956149013010 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 956149013011 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 956149013012 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 956149013013 dimer interface [polypeptide binding]; other site 956149013014 putative CheW interface [polypeptide binding]; other site 956149013015 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 956149013016 potential frameshift: common BLAST hit: gi|156936648|ref|YP_001440562.1| guanine deaminase 956149013017 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 956149013018 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 956149013019 putative C-terminal domain interface [polypeptide binding]; other site 956149013020 putative GSH binding site (G-site) [chemical binding]; other site 956149013021 putative dimer interface [polypeptide binding]; other site 956149013022 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 956149013023 dimer interface [polypeptide binding]; other site 956149013024 N-terminal domain interface [polypeptide binding]; other site 956149013025 substrate binding pocket (H-site) [chemical binding]; other site 956149013026 Cache domain; Region: Cache_1; pfam02743 956149013027 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 956149013028 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 956149013029 dimer interface [polypeptide binding]; other site 956149013030 putative CheW interface [polypeptide binding]; other site 956149013031 AAA ATPase domain; Region: AAA_16; pfam13191 956149013032 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 956149013033 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 956149013034 magnesium-transporting ATPase; Provisional; Region: PRK15122 956149013035 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 956149013036 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 956149013037 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 956149013038 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 956149013039 Soluble P-type ATPase [General function prediction only]; Region: COG4087 956149013040 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 956149013041 Uncharacterized conserved protein [Function unknown]; Region: COG2850 956149013042 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 956149013043 Autotransporter beta-domain; Region: Autotransporter; smart00869 956149013044 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 956149013045 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 956149013046 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 956149013047 active site 956149013048 catalytic site [active] 956149013049 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 956149013050 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 956149013051 active site 956149013052 catalytic site [active] 956149013053 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 956149013054 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 956149013055 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 956149013056 catalytic site [active] 956149013057 active site 956149013058 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 956149013059 HipA N-terminal domain; Region: couple_hipA; TIGR03071 956149013060 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 956149013061 HipA-like N-terminal domain; Region: HipA_N; pfam07805 956149013062 HipA-like C-terminal domain; Region: HipA_C; pfam07804 956149013063 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 956149013064 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 956149013065 salt bridge; other site 956149013066 non-specific DNA binding site [nucleotide binding]; other site 956149013067 sequence-specific DNA binding site [nucleotide binding]; other site 956149013068 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 956149013069 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 956149013070 FAD binding pocket [chemical binding]; other site 956149013071 FAD binding motif [chemical binding]; other site 956149013072 phosphate binding motif [ion binding]; other site 956149013073 NAD binding pocket [chemical binding]; other site 956149013074 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 956149013075 Major Facilitator Superfamily; Region: MFS_1; pfam07690 956149013076 putative substrate translocation pore; other site 956149013077 IucA / IucC family; Region: IucA_IucC; pfam04183 956149013078 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 956149013079 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 956149013080 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 956149013081 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 956149013082 IucA / IucC family; Region: IucA_IucC; pfam04183 956149013083 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 956149013084 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 956149013085 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 956149013086 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 956149013087 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 956149013088 N-terminal plug; other site 956149013089 ligand-binding site [chemical binding]; other site 956149013090 ParB-like nuclease domain; Region: ParB; smart00470 956149013091 ParB family; Region: ParB; pfam08775 956149013092 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 956149013093 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 956149013094 P-loop; other site 956149013095 Magnesium ion binding site [ion binding]; other site 956149013096 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 956149013097 Magnesium ion binding site [ion binding]; other site