-- dump date 20140619_053924 -- class Genbank::misc_feature -- table misc_feature_note -- id note 693216000001 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 693216000002 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 693216000003 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 693216000004 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693216000005 S-adenosylmethionine binding site [chemical binding]; other site 693216000006 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 693216000007 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 693216000008 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 693216000009 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 693216000010 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 693216000011 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 693216000012 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 693216000013 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 693216000014 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 693216000015 beta subunit interaction interface [polypeptide binding]; other site 693216000016 Walker A motif; other site 693216000017 ATP binding site [chemical binding]; other site 693216000018 Walker B motif; other site 693216000019 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 693216000020 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 693216000021 core domain interface [polypeptide binding]; other site 693216000022 delta subunit interface [polypeptide binding]; other site 693216000023 epsilon subunit interface [polypeptide binding]; other site 693216000024 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 693216000025 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 693216000026 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 693216000027 alpha subunit interaction interface [polypeptide binding]; other site 693216000028 Walker A motif; other site 693216000029 ATP binding site [chemical binding]; other site 693216000030 Walker B motif; other site 693216000031 inhibitor binding site; inhibition site 693216000032 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 693216000033 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 693216000034 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 693216000035 gamma subunit interface [polypeptide binding]; other site 693216000036 epsilon subunit interface [polypeptide binding]; other site 693216000037 LBP interface [polypeptide binding]; other site 693216000038 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 693216000039 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 693216000040 Substrate binding site; other site 693216000041 Mg++ binding site; other site 693216000042 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 693216000043 active site 693216000044 substrate binding site [chemical binding]; other site 693216000045 CoA binding site [chemical binding]; other site 693216000046 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 693216000047 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 693216000048 glutaminase active site [active] 693216000049 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 693216000050 dimer interface [polypeptide binding]; other site 693216000051 active site 693216000052 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 693216000053 dimer interface [polypeptide binding]; other site 693216000054 active site 693216000055 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693216000056 substrate binding pocket [chemical binding]; other site 693216000057 membrane-bound complex binding site; other site 693216000058 hinge residues; other site 693216000059 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 693216000060 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216000061 dimer interface [polypeptide binding]; other site 693216000062 conserved gate region; other site 693216000063 putative PBP binding loops; other site 693216000064 ABC-ATPase subunit interface; other site 693216000065 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 693216000066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216000067 dimer interface [polypeptide binding]; other site 693216000068 conserved gate region; other site 693216000069 putative PBP binding loops; other site 693216000070 ABC-ATPase subunit interface; other site 693216000071 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 693216000072 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 693216000073 Walker A/P-loop; other site 693216000074 ATP binding site [chemical binding]; other site 693216000075 Q-loop/lid; other site 693216000076 ABC transporter signature motif; other site 693216000077 Walker B; other site 693216000078 D-loop; other site 693216000079 H-loop/switch region; other site 693216000080 transcriptional regulator PhoU; Provisional; Region: PRK11115 693216000081 PhoU domain; Region: PhoU; pfam01895 693216000082 PhoU domain; Region: PhoU; pfam01895 693216000083 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 693216000084 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 693216000085 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 693216000086 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693216000087 active site 693216000088 motif I; other site 693216000089 motif II; other site 693216000090 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 693216000091 Predicted flavoprotein [General function prediction only]; Region: COG0431 693216000092 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 693216000093 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693216000094 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216000095 2OG-Fe dioxygenase; Region: 2OG-Fe_Oxy_2; pfam10014 693216000096 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693216000097 Coenzyme A binding pocket [chemical binding]; other site 693216000098 AzlC protein; Region: AzlC; pfam03591 693216000099 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 693216000100 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 693216000101 ligand binding site [chemical binding]; other site 693216000102 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 693216000103 active site residue [active] 693216000104 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 693216000105 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 693216000106 trmE is a tRNA modification GTPase; Region: trmE; cd04164 693216000107 G1 box; other site 693216000108 GTP/Mg2+ binding site [chemical binding]; other site 693216000109 Switch I region; other site 693216000110 G2 box; other site 693216000111 Switch II region; other site 693216000112 G3 box; other site 693216000113 G4 box; other site 693216000114 G5 box; other site 693216000115 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 693216000116 membrane protein insertase; Provisional; Region: PRK01318 693216000117 YidC periplasmic domain; Region: YidC_periplas; pfam14849 693216000118 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 693216000119 hypothetical protein; Validated; Region: PRK00041 693216000120 ribonuclease P; Reviewed; Region: rnpA; PRK01732 693216000121 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 693216000122 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 693216000123 DnaA N-terminal domain; Region: DnaA_N; pfam11638 693216000124 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693216000125 Walker A motif; other site 693216000126 ATP binding site [chemical binding]; other site 693216000127 Walker B motif; other site 693216000128 arginine finger; other site 693216000129 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 693216000130 DnaA box-binding interface [nucleotide binding]; other site 693216000131 DNA polymerase III subunit beta; Validated; Region: PRK05643 693216000132 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 693216000133 putative DNA binding surface [nucleotide binding]; other site 693216000134 dimer interface [polypeptide binding]; other site 693216000135 beta-clamp/clamp loader binding surface; other site 693216000136 beta-clamp/translesion DNA polymerase binding surface; other site 693216000137 recF protein; Region: recf; TIGR00611 693216000138 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693216000139 Walker A/P-loop; other site 693216000140 ATP binding site [chemical binding]; other site 693216000141 Q-loop/lid; other site 693216000142 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693216000143 ABC transporter signature motif; other site 693216000144 Walker B; other site 693216000145 D-loop; other site 693216000146 H-loop/switch region; other site 693216000147 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 693216000148 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693216000149 ATP binding site [chemical binding]; other site 693216000150 Mg2+ binding site [ion binding]; other site 693216000151 G-X-G motif; other site 693216000152 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 693216000153 anchoring element; other site 693216000154 dimer interface [polypeptide binding]; other site 693216000155 ATP binding site [chemical binding]; other site 693216000156 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 693216000157 active site 693216000158 putative metal-binding site [ion binding]; other site 693216000159 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 693216000160 sugar phosphate phosphatase; Provisional; Region: PRK10513 693216000161 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693216000162 active site 693216000163 motif I; other site 693216000164 motif II; other site 693216000165 small toxic polypeptide; Provisional; Region: PRK09738 693216000166 Transcriptional regulators [Transcription]; Region: FadR; COG2186 693216000167 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693216000168 DNA-binding site [nucleotide binding]; DNA binding site 693216000169 FCD domain; Region: FCD; pfam07729 693216000170 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 693216000171 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 693216000172 active site 693216000173 intersubunit interface [polypeptide binding]; other site 693216000174 catalytic residue [active] 693216000175 galactonate dehydratase; Provisional; Region: PRK14017 693216000176 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 693216000177 putative active site pocket [active] 693216000178 putative metal binding site [ion binding]; other site 693216000179 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216000180 D-galactonate transporter; Region: 2A0114; TIGR00893 693216000181 putative substrate translocation pore; other site 693216000182 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 693216000183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216000184 putative substrate translocation pore; other site 693216000185 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 693216000186 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 693216000187 putative ligand binding site [chemical binding]; other site 693216000188 NAD binding site [chemical binding]; other site 693216000189 catalytic site [active] 693216000190 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 693216000191 hypothetical protein; Provisional; Region: PRK11616 693216000192 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 693216000193 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 693216000194 putative dimer interface [polypeptide binding]; other site 693216000195 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 693216000196 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 693216000197 putative dimer interface [polypeptide binding]; other site 693216000198 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 693216000199 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693216000200 DNA-binding site [nucleotide binding]; DNA binding site 693216000201 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 693216000202 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 693216000203 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 693216000204 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 693216000205 active site turn [active] 693216000206 phosphorylation site [posttranslational modification] 693216000207 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 693216000208 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 693216000209 NAD binding site [chemical binding]; other site 693216000210 sugar binding site [chemical binding]; other site 693216000211 divalent metal binding site [ion binding]; other site 693216000212 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 693216000213 dimer interface [polypeptide binding]; other site 693216000214 Domain of unknown function (DUF202); Region: DUF202; cl09954 693216000215 Domain of unknown function (DUF202); Region: DUF202; pfam02656 693216000216 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 693216000217 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 693216000218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216000219 putative substrate translocation pore; other site 693216000220 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 693216000221 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693216000222 Coenzyme A binding pocket [chemical binding]; other site 693216000223 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 693216000224 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 693216000225 hypothetical protein; Provisional; Region: PRK07033 693216000226 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 693216000227 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693216000228 ligand binding site [chemical binding]; other site 693216000229 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 693216000230 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 693216000231 G1 box; other site 693216000232 GTP/Mg2+ binding site [chemical binding]; other site 693216000233 G2 box; other site 693216000234 Switch I region; other site 693216000235 G3 box; other site 693216000236 Switch II region; other site 693216000237 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 693216000238 G4 box; other site 693216000239 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 693216000240 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 693216000241 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 693216000242 ImpA-related N-terminal; Region: ImpA-rel_N; cl19907 693216000243 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 693216000244 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 693216000245 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 693216000246 Protein of unknown function (DUF796); Region: DUF796; pfam05638 693216000247 DMSO reductase family type II enzyme, molybdopterin subunit; Region: DMSO_red_II_alp; TIGR03479 693216000248 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 693216000249 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 693216000250 active site 693216000251 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 693216000252 ImpE protein; Region: ImpE; pfam07024 693216000253 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 693216000254 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 693216000255 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 693216000256 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 693216000257 Clp amino terminal domain; Region: Clp_N; pfam02861 693216000258 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693216000259 Walker A motif; other site 693216000260 ATP binding site [chemical binding]; other site 693216000261 Walker B motif; other site 693216000262 arginine finger; other site 693216000263 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693216000264 Walker A motif; other site 693216000265 ATP binding site [chemical binding]; other site 693216000266 Walker B motif; other site 693216000267 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 693216000268 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 693216000269 Catalytic domain of Protein Kinases; Region: PKc; cd00180 693216000270 active site 693216000271 ATP binding site [chemical binding]; other site 693216000272 substrate binding site [chemical binding]; other site 693216000273 activation loop (A-loop); other site 693216000274 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 693216000275 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 693216000276 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 693216000277 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 693216000278 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 693216000279 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 693216000280 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 693216000281 PAAR motif; Region: PAAR_motif; pfam05488 693216000282 Lipopolysaccharide-assembly; Region: LptE; cl01125 693216000283 RHS Repeat; Region: RHS_repeat; pfam05593 693216000284 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 693216000285 RHS Repeat; Region: RHS_repeat; pfam05593 693216000286 RHS Repeat; Region: RHS_repeat; pfam05593 693216000287 RHS Repeat; Region: RHS_repeat; pfam05593 693216000288 RHS Repeat; Region: RHS_repeat; pfam05593 693216000289 RHS Repeat; Region: RHS_repeat; pfam05593 693216000290 RHS Repeat; Region: RHS_repeat; pfam05593 693216000291 RHS protein; Region: RHS; pfam03527 693216000292 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 693216000293 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 693216000294 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 693216000295 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 693216000296 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 693216000297 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 693216000298 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 693216000299 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 693216000300 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 693216000301 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 693216000302 nucleophilic elbow; other site 693216000303 catalytic triad; other site 693216000304 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 693216000305 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 693216000306 RHS Repeat; Region: RHS_repeat; pfam05593 693216000307 RHS Repeat; Region: RHS_repeat; pfam05593 693216000308 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 693216000309 RHS Repeat; Region: RHS_repeat; pfam05593 693216000310 RHS Repeat; Region: RHS_repeat; pfam05593 693216000311 RHS protein; Region: RHS; pfam03527 693216000312 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 693216000313 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 693216000314 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 693216000315 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 693216000316 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 693216000317 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 693216000318 PAAR motif; Region: PAAR_motif; pfam05488 693216000319 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 693216000320 RHS Repeat; Region: RHS_repeat; pfam05593 693216000321 RHS Repeat; Region: RHS_repeat; pfam05593 693216000322 RHS Repeat; Region: RHS_repeat; pfam05593 693216000323 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 693216000324 RHS Repeat; Region: RHS_repeat; pfam05593 693216000325 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 693216000326 RHS protein; Region: RHS; pfam03527 693216000327 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 693216000328 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 693216000329 RHS protein; Region: RHS; pfam03527 693216000330 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 693216000331 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 693216000332 A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414 693216000333 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 693216000334 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 693216000335 RHS Repeat; Region: RHS_repeat; pfam05593 693216000336 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 693216000337 RHS protein; Region: RHS; pfam03527 693216000338 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 693216000339 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 693216000340 substrate binding site [chemical binding]; other site 693216000341 dimer interface [polypeptide binding]; other site 693216000342 catalytic triad [active] 693216000343 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 693216000344 Predicted membrane protein [Function unknown]; Region: COG3152 693216000345 ferredoxin-NADP reductase; Provisional; Region: PRK10926 693216000346 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 693216000347 FAD binding pocket [chemical binding]; other site 693216000348 FAD binding motif [chemical binding]; other site 693216000349 phosphate binding motif [ion binding]; other site 693216000350 beta-alpha-beta structure motif; other site 693216000351 NAD binding pocket [chemical binding]; other site 693216000352 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 693216000353 putative active site [active] 693216000354 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 693216000355 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 693216000356 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 693216000357 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 693216000358 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 693216000359 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 693216000360 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 693216000361 active site 693216000362 P-loop; other site 693216000363 phosphorylation site [posttranslational modification] 693216000364 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 693216000365 active site 693216000366 phosphorylation site [posttranslational modification] 693216000367 putative glutathione S-transferase; Provisional; Region: PRK10357 693216000368 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 693216000369 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 693216000370 dimer interface [polypeptide binding]; other site 693216000371 N-terminal domain interface [polypeptide binding]; other site 693216000372 putative substrate binding pocket (H-site) [chemical binding]; other site 693216000373 selenocysteine synthase; Provisional; Region: PRK04311 693216000374 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 693216000375 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 693216000376 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 693216000377 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 693216000378 G1 box; other site 693216000379 putative GEF interaction site [polypeptide binding]; other site 693216000380 GTP/Mg2+ binding site [chemical binding]; other site 693216000381 Switch I region; other site 693216000382 G2 box; other site 693216000383 G3 box; other site 693216000384 Switch II region; other site 693216000385 G4 box; other site 693216000386 G5 box; other site 693216000387 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 693216000388 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 693216000389 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 693216000390 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 693216000391 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 693216000392 dimer interface [polypeptide binding]; other site 693216000393 active site 693216000394 metal binding site [ion binding]; metal-binding site 693216000395 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 693216000396 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 693216000397 nucleotide binding site [chemical binding]; other site 693216000398 LysE type translocator; Region: LysE; cl00565 693216000399 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 693216000400 oligomeric interface; other site 693216000401 putative active site [active] 693216000402 homodimer interface [polypeptide binding]; other site 693216000403 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 693216000404 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 693216000405 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 693216000406 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 693216000407 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 693216000408 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 693216000409 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 693216000410 molybdopterin cofactor binding site; other site 693216000411 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 693216000412 molybdopterin cofactor binding site; other site 693216000413 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 693216000414 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 693216000415 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 693216000416 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 693216000417 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 693216000418 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 693216000419 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693216000420 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693216000421 non-specific DNA binding site [nucleotide binding]; other site 693216000422 salt bridge; other site 693216000423 sequence-specific DNA binding site [nucleotide binding]; other site 693216000424 Cupin domain; Region: Cupin_2; cl17218 693216000425 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693216000426 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693216000427 DNA binding site [nucleotide binding] 693216000428 domain linker motif; other site 693216000429 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 693216000430 ligand binding site [chemical binding]; other site 693216000431 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 693216000432 Melibiase; Region: Melibiase; pfam02065 693216000433 galactoside permease; Reviewed; Region: lacY; PRK09528 693216000434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216000435 putative substrate translocation pore; other site 693216000436 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 693216000437 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 693216000438 dimer interface [polypeptide binding]; other site 693216000439 active site 693216000440 metal binding site [ion binding]; metal-binding site 693216000441 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 693216000442 intersubunit interface [polypeptide binding]; other site 693216000443 active site 693216000444 Zn2+ binding site [ion binding]; other site 693216000445 L-rhamnose isomerase; Provisional; Region: PRK01076 693216000446 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 693216000447 N- and C-terminal domain interface [polypeptide binding]; other site 693216000448 active site 693216000449 putative catalytic site [active] 693216000450 metal binding site [ion binding]; metal-binding site 693216000451 ATP binding site [chemical binding]; other site 693216000452 rhamnulokinase; Provisional; Region: rhaB; PRK10640 693216000453 carbohydrate binding site [chemical binding]; other site 693216000454 transcriptional activator RhaS; Provisional; Region: PRK13503 693216000455 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 693216000456 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693216000457 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693216000458 transcriptional activator RhaR; Provisional; Region: PRK13501 693216000459 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 693216000460 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693216000461 Sugar transport protein; Region: Sugar_transport; cl19288 693216000462 superoxide dismutase; Provisional; Region: PRK10925 693216000463 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 693216000464 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 693216000465 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 693216000466 MOSC domain; Region: MOSC; pfam03473 693216000467 3-alpha domain; Region: 3-alpha; pfam03475 693216000468 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 693216000469 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 693216000470 active site 693216000471 substrate binding site [chemical binding]; other site 693216000472 FMN binding site [chemical binding]; other site 693216000473 putative catalytic residues [active] 693216000474 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 693216000475 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693216000476 DNA-binding site [nucleotide binding]; DNA binding site 693216000477 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 693216000478 L-lactate permease; Provisional; Region: PRK10420 693216000479 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693216000480 salt bridge; other site 693216000481 non-specific DNA binding site [nucleotide binding]; other site 693216000482 sequence-specific DNA binding site [nucleotide binding]; other site 693216000483 hypothetical protein; Provisional; Region: PRK11020 693216000484 glycerol kinase; Provisional; Region: glpK; PRK00047 693216000485 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 693216000486 N- and C-terminal domain interface [polypeptide binding]; other site 693216000487 active site 693216000488 MgATP binding site [chemical binding]; other site 693216000489 catalytic site [active] 693216000490 metal binding site [ion binding]; metal-binding site 693216000491 glycerol binding site [chemical binding]; other site 693216000492 homotetramer interface [polypeptide binding]; other site 693216000493 homodimer interface [polypeptide binding]; other site 693216000494 FBP binding site [chemical binding]; other site 693216000495 protein IIAGlc interface [polypeptide binding]; other site 693216000496 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 693216000497 amphipathic channel; other site 693216000498 Asn-Pro-Ala signature motifs; other site 693216000499 Protein of unknown function (DUF904); Region: DUF904; cl11531 693216000500 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 693216000501 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 693216000502 putative active site [active] 693216000503 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 693216000504 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693216000505 Walker A motif; other site 693216000506 ATP binding site [chemical binding]; other site 693216000507 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693216000508 Walker B motif; other site 693216000509 arginine finger; other site 693216000510 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 693216000511 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 693216000512 active site 693216000513 HslU subunit interaction site [polypeptide binding]; other site 693216000514 cell division protein FtsN; Provisional; Region: PRK12757 693216000515 Sporulation related domain; Region: SPOR; pfam05036 693216000516 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693216000517 DNA binding site [nucleotide binding] 693216000518 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 693216000519 domain linker motif; other site 693216000520 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 693216000521 dimerization interface [polypeptide binding]; other site 693216000522 ligand binding site [chemical binding]; other site 693216000523 primosome assembly protein PriA; Validated; Region: PRK05580 693216000524 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693216000525 ATP binding site [chemical binding]; other site 693216000526 putative Mg++ binding site [ion binding]; other site 693216000527 helicase superfamily c-terminal domain; Region: HELICc; smart00490 693216000528 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 693216000529 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 693216000530 dimerization interface [polypeptide binding]; other site 693216000531 DNA binding site [nucleotide binding] 693216000532 corepressor binding sites; other site 693216000533 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 693216000534 homodimer interface [polypeptide binding]; other site 693216000535 substrate-cofactor binding pocket; other site 693216000536 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216000537 catalytic residue [active] 693216000538 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 693216000539 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 693216000540 putative catalytic residues [active] 693216000541 putative nucleotide binding site [chemical binding]; other site 693216000542 putative aspartate binding site [chemical binding]; other site 693216000543 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 693216000544 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 693216000545 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 693216000546 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 693216000547 FAD binding site [chemical binding]; other site 693216000548 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693216000549 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 693216000550 putative active site [active] 693216000551 heme pocket [chemical binding]; other site 693216000552 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693216000553 putative active site [active] 693216000554 heme pocket [chemical binding]; other site 693216000555 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 693216000556 dimer interface [polypeptide binding]; other site 693216000557 putative CheW interface [polypeptide binding]; other site 693216000558 malate:quinone oxidoreductase; Validated; Region: PRK05257 693216000559 Predicted dehydrogenase [General function prediction only]; Region: COG0579 693216000560 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 693216000561 putative chaperone protein EcpD; Provisional; Region: PRK09926 693216000562 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 693216000563 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 693216000564 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 693216000565 PapC N-terminal domain; Region: PapC_N; pfam13954 693216000566 Outer membrane usher protein; Region: Usher; pfam00577 693216000567 PapC C-terminal domain; Region: PapC_C; pfam13953 693216000568 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 693216000569 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 693216000570 acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892 693216000571 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 693216000572 metal binding site [ion binding]; metal-binding site 693216000573 putative dimer interface [polypeptide binding]; other site 693216000574 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 693216000575 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 693216000576 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 693216000577 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 693216000578 nucleotide binding site [chemical binding]; other site 693216000579 N-acetyl-L-glutamate binding site [chemical binding]; other site 693216000580 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 693216000581 ANP binding site [chemical binding]; other site 693216000582 Substrate Binding Site II [chemical binding]; other site 693216000583 Substrate Binding Site I [chemical binding]; other site 693216000584 argininosuccinate lyase; Provisional; Region: PRK04833 693216000585 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 693216000586 active sites [active] 693216000587 tetramer interface [polypeptide binding]; other site 693216000588 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 693216000589 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216000590 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 693216000591 dimerization interface [polypeptide binding]; other site 693216000592 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 693216000593 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 693216000594 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693216000595 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 693216000596 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 693216000597 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693216000598 hypothetical protein; Provisional; Region: PRK11056 693216000599 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 693216000600 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693216000601 S-adenosylmethionine binding site [chemical binding]; other site 693216000602 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 693216000603 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693216000604 N-terminal plug; other site 693216000605 ligand-binding site [chemical binding]; other site 693216000606 glutamate racemase; Provisional; Region: PRK00865 693216000607 transcriptional regulator HdfR; Provisional; Region: PRK03601 693216000608 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216000609 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693216000610 dimerization interface [polypeptide binding]; other site 693216000611 hypothetical protein; Provisional; Region: PRK11027 693216000612 putative ATP-dependent protease; Provisional; Region: PRK09862 693216000613 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 693216000614 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 693216000615 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693216000616 Walker A motif; other site 693216000617 ATP binding site [chemical binding]; other site 693216000618 Walker B motif; other site 693216000619 arginine finger; other site 693216000620 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 693216000621 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 693216000622 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 693216000623 PYR/PP interface [polypeptide binding]; other site 693216000624 dimer interface [polypeptide binding]; other site 693216000625 TPP binding site [chemical binding]; other site 693216000626 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 693216000627 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 693216000628 TPP-binding site [chemical binding]; other site 693216000629 dimer interface [polypeptide binding]; other site 693216000630 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 693216000631 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 693216000632 homodimer interface [polypeptide binding]; other site 693216000633 substrate-cofactor binding pocket; other site 693216000634 catalytic residue [active] 693216000635 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 693216000636 threonine dehydratase; Reviewed; Region: PRK09224 693216000637 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 693216000638 tetramer interface [polypeptide binding]; other site 693216000639 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216000640 catalytic residue [active] 693216000641 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 693216000642 putative Ile/Val binding site [chemical binding]; other site 693216000643 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 693216000644 putative Ile/Val binding site [chemical binding]; other site 693216000645 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216000646 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 693216000647 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 693216000648 putative dimerization interface [polypeptide binding]; other site 693216000649 ketol-acid reductoisomerase; Validated; Region: PRK05225 693216000650 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 693216000651 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 693216000652 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 693216000653 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 693216000654 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 693216000655 Part of AAA domain; Region: AAA_19; pfam13245 693216000656 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 693216000657 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 693216000658 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 693216000659 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 693216000660 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 693216000661 ATP binding site [chemical binding]; other site 693216000662 Mg++ binding site [ion binding]; other site 693216000663 motif III; other site 693216000664 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693216000665 nucleotide binding region [chemical binding]; other site 693216000666 ATP-binding site [chemical binding]; other site 693216000667 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 693216000668 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 693216000669 catalytic residues [active] 693216000670 transcription termination factor Rho; Provisional; Region: rho; PRK09376 693216000671 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 693216000672 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 693216000673 RNA binding site [nucleotide binding]; other site 693216000674 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 693216000675 multimer interface [polypeptide binding]; other site 693216000676 Walker A motif; other site 693216000677 ATP binding site [chemical binding]; other site 693216000678 Walker B motif; other site 693216000679 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 693216000680 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 693216000681 Mg++ binding site [ion binding]; other site 693216000682 putative catalytic motif [active] 693216000683 substrate binding site [chemical binding]; other site 693216000684 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 693216000685 Chain length determinant protein; Region: Wzz; pfam02706 693216000686 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 693216000687 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 693216000688 active site 693216000689 homodimer interface [polypeptide binding]; other site 693216000690 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 693216000691 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 693216000692 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 693216000693 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 693216000694 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 693216000695 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 693216000696 NAD binding site [chemical binding]; other site 693216000697 substrate binding site [chemical binding]; other site 693216000698 homodimer interface [polypeptide binding]; other site 693216000699 active site 693216000700 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 693216000701 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 693216000702 substrate binding site; other site 693216000703 tetramer interface; other site 693216000704 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 693216000705 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 693216000706 inhibitor-cofactor binding pocket; inhibition site 693216000707 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216000708 catalytic residue [active] 693216000709 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 693216000710 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 693216000711 putative common antigen polymerase; Provisional; Region: PRK02975 693216000712 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 693216000713 putative transport protein YifK; Provisional; Region: PRK10746 693216000714 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693216000715 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693216000716 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693216000717 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693216000718 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693216000719 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693216000720 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693216000721 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693216000722 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693216000723 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693216000724 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693216000725 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693216000726 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693216000727 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693216000728 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 693216000729 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693216000730 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693216000731 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693216000732 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693216000733 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693216000734 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693216000735 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 693216000736 HemY protein N-terminus; Region: HemY_N; pfam07219 693216000737 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693216000738 TPR motif; other site 693216000739 binding surface 693216000740 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 693216000741 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 693216000742 active site 693216000743 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 693216000744 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 693216000745 domain interfaces; other site 693216000746 active site 693216000747 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 693216000748 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 693216000749 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 693216000750 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 693216000751 putative iron binding site [ion binding]; other site 693216000752 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 693216000753 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 693216000754 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 693216000755 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 693216000756 hypothetical protein; Provisional; Region: PRK10963 693216000757 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 693216000758 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 693216000759 active site 693216000760 Int/Topo IB signature motif; other site 693216000761 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 693216000762 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693216000763 motif II; other site 693216000764 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 693216000765 Part of AAA domain; Region: AAA_19; pfam13245 693216000766 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 693216000767 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 693216000768 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 693216000769 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 693216000770 Cl binding site [ion binding]; other site 693216000771 oligomer interface [polypeptide binding]; other site 693216000772 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 693216000773 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 693216000774 EamA-like transporter family; Region: EamA; cl17759 693216000775 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 693216000776 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 693216000777 CoenzymeA binding site [chemical binding]; other site 693216000778 subunit interaction site [polypeptide binding]; other site 693216000779 PHB binding site; other site 693216000780 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 693216000781 dimerization interface [polypeptide binding]; other site 693216000782 substrate binding site [chemical binding]; other site 693216000783 active site 693216000784 calcium binding site [ion binding]; other site 693216000785 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 693216000786 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693216000787 ATP binding site [chemical binding]; other site 693216000788 putative Mg++ binding site [ion binding]; other site 693216000789 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693216000790 nucleotide binding region [chemical binding]; other site 693216000791 ATP-binding site [chemical binding]; other site 693216000792 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 693216000793 HRDC domain; Region: HRDC; pfam00570 693216000794 threonine efflux system; Provisional; Region: PRK10229 693216000795 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 693216000796 lysophospholipase L2; Provisional; Region: PRK10749 693216000797 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 693216000798 putative hydrolase; Provisional; Region: PRK10976 693216000799 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693216000800 active site 693216000801 motif I; other site 693216000802 motif II; other site 693216000803 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 693216000804 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 693216000805 EamA-like transporter family; Region: EamA; pfam00892 693216000806 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 693216000807 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216000808 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 693216000809 putative dimerization interface [polypeptide binding]; other site 693216000810 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 693216000811 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 693216000812 THF binding site; other site 693216000813 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 693216000814 substrate binding site [chemical binding]; other site 693216000815 THF binding site; other site 693216000816 zinc-binding site [ion binding]; other site 693216000817 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 693216000818 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 693216000819 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 693216000820 uridine phosphorylase; Provisional; Region: PRK11178 693216000821 DNA recombination protein RmuC; Provisional; Region: PRK10361 693216000822 RmuC family; Region: RmuC; pfam02646 693216000823 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 693216000824 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693216000825 S-adenosylmethionine binding site [chemical binding]; other site 693216000826 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 693216000827 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 693216000828 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 693216000829 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 693216000830 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 693216000831 sec-independent translocase; Provisional; Region: PRK01770 693216000832 sec-independent translocase; Provisional; Region: tatB; PRK00404 693216000833 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 693216000834 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 693216000835 active site 693216000836 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 693216000837 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 693216000838 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 693216000839 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 693216000840 FMN reductase; Validated; Region: fre; PRK08051 693216000841 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 693216000842 FAD binding pocket [chemical binding]; other site 693216000843 FAD binding motif [chemical binding]; other site 693216000844 phosphate binding motif [ion binding]; other site 693216000845 beta-alpha-beta structure motif; other site 693216000846 NAD binding pocket [chemical binding]; other site 693216000847 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 693216000848 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 693216000849 dimer interface [polypeptide binding]; other site 693216000850 active site 693216000851 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 693216000852 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693216000853 substrate binding site [chemical binding]; other site 693216000854 oxyanion hole (OAH) forming residues; other site 693216000855 trimer interface [polypeptide binding]; other site 693216000856 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 693216000857 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 693216000858 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 693216000859 proline dipeptidase; Provisional; Region: PRK13607 693216000860 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 693216000861 active site 693216000862 hypothetical protein; Provisional; Region: PRK11568 693216000863 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 693216000864 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 693216000865 potassium transporter; Provisional; Region: PRK10750 693216000866 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 693216000867 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 693216000868 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 693216000869 FAD binding domain; Region: FAD_binding_4; pfam01565 693216000870 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 693216000871 Biotin operon repressor [Transcription]; Region: BirA; COG1654 693216000872 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 693216000873 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 693216000874 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 693216000875 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 693216000876 ATP-binding site [chemical binding]; other site 693216000877 CoA-binding site [chemical binding]; other site 693216000878 Mg2+-binding site [ion binding]; other site 693216000879 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 693216000880 G1 box; other site 693216000881 GTP/Mg2+ binding site [chemical binding]; other site 693216000882 elongation factor Tu; Reviewed; Region: PRK00049 693216000883 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 693216000884 GTP/Mg2+ binding site [chemical binding]; other site 693216000885 GEF interaction site [polypeptide binding]; other site 693216000886 Switch I region; other site 693216000887 G2 box; other site 693216000888 G3 box; other site 693216000889 Switch II region; other site 693216000890 G4 box; other site 693216000891 G5 box; other site 693216000892 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 693216000893 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 693216000894 Antibiotic Binding Site [chemical binding]; other site 693216000895 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 693216000896 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 693216000897 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 693216000898 putative homodimer interface [polypeptide binding]; other site 693216000899 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 693216000900 heterodimer interface [polypeptide binding]; other site 693216000901 homodimer interface [polypeptide binding]; other site 693216000902 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 693216000903 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 693216000904 23S rRNA interface [nucleotide binding]; other site 693216000905 L7/L12 interface [polypeptide binding]; other site 693216000906 putative thiostrepton binding site; other site 693216000907 L25 interface [polypeptide binding]; other site 693216000908 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 693216000909 mRNA/rRNA interface [nucleotide binding]; other site 693216000910 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 693216000911 23S rRNA interface [nucleotide binding]; other site 693216000912 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 693216000913 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 693216000914 core dimer interface [polypeptide binding]; other site 693216000915 peripheral dimer interface [polypeptide binding]; other site 693216000916 L10 interface [polypeptide binding]; other site 693216000917 L11 interface [polypeptide binding]; other site 693216000918 putative EF-Tu interaction site [polypeptide binding]; other site 693216000919 putative EF-G interaction site [polypeptide binding]; other site 693216000920 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 693216000921 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 693216000922 RPB12 interaction site [polypeptide binding]; other site 693216000923 RPB1 interaction site [polypeptide binding]; other site 693216000924 RPB10 interaction site [polypeptide binding]; other site 693216000925 RPB11 interaction site [polypeptide binding]; other site 693216000926 RPB3 interaction site [polypeptide binding]; other site 693216000927 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 693216000928 beta and beta' interface [polypeptide binding]; other site 693216000929 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 693216000930 beta' and sigma factor interface [polypeptide binding]; other site 693216000931 Zn-binding [ion binding]; other site 693216000932 active site region [active] 693216000933 catalytic site [active] 693216000934 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 693216000935 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 693216000936 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 693216000937 G-loop; other site 693216000938 DNA binding site [nucleotide binding] 693216000939 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 693216000940 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 693216000941 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 693216000942 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 693216000943 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693216000944 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 693216000945 methionine cluster; other site 693216000946 active site 693216000947 phosphorylation site [posttranslational modification] 693216000948 metal binding site [ion binding]; metal-binding site 693216000949 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 693216000950 active site 693216000951 P-loop; other site 693216000952 phosphorylation site [posttranslational modification] 693216000953 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 693216000954 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693216000955 FeS/SAM binding site; other site 693216000956 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 693216000957 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 693216000958 ThiS interaction site; other site 693216000959 putative active site [active] 693216000960 tetramer interface [polypeptide binding]; other site 693216000961 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 693216000962 thiS-thiF/thiG interaction site; other site 693216000963 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 693216000964 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 693216000965 ATP binding site [chemical binding]; other site 693216000966 substrate interface [chemical binding]; other site 693216000967 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 693216000968 thiamine phosphate binding site [chemical binding]; other site 693216000969 active site 693216000970 pyrophosphate binding site [ion binding]; other site 693216000971 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 693216000972 ThiC-associated domain; Region: ThiC-associated; pfam13667 693216000973 ThiC family; Region: ThiC; pfam01964 693216000974 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 693216000975 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 693216000976 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 693216000977 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 693216000978 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 693216000979 putative NADH binding site [chemical binding]; other site 693216000980 putative active site [active] 693216000981 nudix motif; other site 693216000982 putative metal binding site [ion binding]; other site 693216000983 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 693216000984 substrate binding site [chemical binding]; other site 693216000985 active site 693216000986 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 693216000987 Active_site [active] 693216000988 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 693216000989 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 693216000990 IHF dimer interface [polypeptide binding]; other site 693216000991 IHF - DNA interface [nucleotide binding]; other site 693216000992 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 693216000993 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 693216000994 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 693216000995 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 693216000996 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 693216000997 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 693216000998 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 693216000999 purine monophosphate binding site [chemical binding]; other site 693216001000 dimer interface [polypeptide binding]; other site 693216001001 putative catalytic residues [active] 693216001002 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 693216001003 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 693216001004 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 693216001005 Walker A/P-loop; other site 693216001006 ATP binding site [chemical binding]; other site 693216001007 Q-loop/lid; other site 693216001008 ABC transporter signature motif; other site 693216001009 Walker B; other site 693216001010 D-loop; other site 693216001011 H-loop/switch region; other site 693216001012 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 693216001013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216001014 dimer interface [polypeptide binding]; other site 693216001015 conserved gate region; other site 693216001016 putative PBP binding loops; other site 693216001017 ABC-ATPase subunit interface; other site 693216001018 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 693216001019 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 693216001020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216001021 dimer interface [polypeptide binding]; other site 693216001022 ABC-ATPase subunit interface; other site 693216001023 putative PBP binding loops; other site 693216001024 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 693216001025 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693216001026 substrate binding pocket [chemical binding]; other site 693216001027 membrane-bound complex binding site; other site 693216001028 hinge residues; other site 693216001029 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 693216001030 MMPL family; Region: MMPL; cl14618 693216001031 MMPL family; Region: MMPL; cl14618 693216001032 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 693216001033 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693216001034 HlyD family secretion protein; Region: HlyD_3; pfam13437 693216001035 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 693216001036 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693216001037 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 693216001038 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 693216001039 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 693216001040 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 693216001041 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693216001042 metal binding site [ion binding]; metal-binding site 693216001043 active site 693216001044 I-site; other site 693216001045 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693216001046 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 693216001047 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 693216001048 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 693216001049 FMN binding site [chemical binding]; other site 693216001050 active site 693216001051 catalytic residues [active] 693216001052 substrate binding site [chemical binding]; other site 693216001053 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 693216001054 active site 693216001055 zinc binding site [ion binding]; other site 693216001056 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 693216001057 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693216001058 S-adenosylmethionine binding site [chemical binding]; other site 693216001059 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 693216001060 Na binding site [ion binding]; other site 693216001061 hypothetical protein; Provisional; Region: PRK10633 693216001062 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 693216001063 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 693216001064 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 693216001065 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 693216001066 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 693216001067 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 693216001068 carboxyltransferase (CT) interaction site; other site 693216001069 biotinylation site [posttranslational modification]; other site 693216001070 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 693216001071 trimer interface [polypeptide binding]; other site 693216001072 active site 693216001073 dimer interface [polypeptide binding]; other site 693216001074 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 693216001075 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 693216001076 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 693216001077 Moco binding site; other site 693216001078 metal coordination site [ion binding]; other site 693216001079 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 693216001080 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 693216001081 NADP binding site [chemical binding]; other site 693216001082 dimer interface [polypeptide binding]; other site 693216001083 regulatory protein CsrD; Provisional; Region: PRK11059 693216001084 diguanylate cyclase; Region: GGDEF; smart00267 693216001085 nucleotidyl binding site; other site 693216001086 metal binding site [ion binding]; metal-binding site 693216001087 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693216001088 rod shape-determining protein MreB; Provisional; Region: PRK13927 693216001089 MreB and similar proteins; Region: MreB_like; cd10225 693216001090 nucleotide binding site [chemical binding]; other site 693216001091 Mg binding site [ion binding]; other site 693216001092 putative protofilament interaction site [polypeptide binding]; other site 693216001093 RodZ interaction site [polypeptide binding]; other site 693216001094 rod shape-determining protein MreC; Region: mreC; TIGR00219 693216001095 rod shape-determining protein MreD; Provisional; Region: PRK11060 693216001096 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 693216001097 active site 693216001098 dimer interface [polypeptide binding]; other site 693216001099 ribonuclease G; Provisional; Region: PRK11712 693216001100 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 693216001101 homodimer interface [polypeptide binding]; other site 693216001102 oligonucleotide binding site [chemical binding]; other site 693216001103 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 693216001104 hypothetical protein; Provisional; Region: PRK10899 693216001105 Protein of unknown function; Region: DUF3971; pfam13116 693216001106 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 693216001107 protease TldD; Provisional; Region: tldD; PRK10735 693216001108 transcriptional regulator; Provisional; Region: PRK10632 693216001109 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216001110 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693216001111 putative effector binding pocket; other site 693216001112 dimerization interface [polypeptide binding]; other site 693216001113 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 693216001114 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693216001115 HlyD family secretion protein; Region: HlyD_3; pfam13437 693216001116 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 693216001117 Fusaric acid resistance protein family; Region: FUSC; pfam04632 693216001118 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 693216001119 tetramerization interface [polypeptide binding]; other site 693216001120 NAD(P) binding site [chemical binding]; other site 693216001121 catalytic residues [active] 693216001122 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 693216001123 RNAase interaction site [polypeptide binding]; other site 693216001124 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 693216001125 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 693216001126 arginine repressor; Provisional; Region: PRK05066 693216001127 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 693216001128 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 693216001129 malate dehydrogenase; Provisional; Region: PRK05086 693216001130 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 693216001131 NAD binding site [chemical binding]; other site 693216001132 dimerization interface [polypeptide binding]; other site 693216001133 Substrate binding site [chemical binding]; other site 693216001134 serine endoprotease; Provisional; Region: PRK10898 693216001135 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 693216001136 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 693216001137 protein binding site [polypeptide binding]; other site 693216001138 serine endoprotease; Provisional; Region: PRK10139 693216001139 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 693216001140 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 693216001141 protein binding site [polypeptide binding]; other site 693216001142 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 693216001143 hypothetical protein; Provisional; Region: PRK11677 693216001144 Predicted ATPase [General function prediction only]; Region: COG1485 693216001145 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 693216001146 23S rRNA interface [nucleotide binding]; other site 693216001147 L3 interface [polypeptide binding]; other site 693216001148 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 693216001149 stringent starvation protein A; Provisional; Region: sspA; PRK09481 693216001150 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 693216001151 C-terminal domain interface [polypeptide binding]; other site 693216001152 putative GSH binding site (G-site) [chemical binding]; other site 693216001153 dimer interface [polypeptide binding]; other site 693216001154 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 693216001155 dimer interface [polypeptide binding]; other site 693216001156 N-terminal domain interface [polypeptide binding]; other site 693216001157 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 693216001158 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 693216001159 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 693216001160 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 693216001161 Autotransporter beta-domain; Region: Autotransporter; smart00869 693216001162 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 693216001163 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 693216001164 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 693216001165 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693216001166 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 693216001167 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 693216001168 active site 693216001169 dimer interface [polypeptide binding]; other site 693216001170 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 693216001171 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 693216001172 active site 693216001173 FMN binding site [chemical binding]; other site 693216001174 substrate binding site [chemical binding]; other site 693216001175 3Fe-4S cluster binding site [ion binding]; other site 693216001176 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 693216001177 domain interface; other site 693216001178 radical SAM protein, TIGR01212 family; Region: TIGR01212 693216001179 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693216001180 FeS/SAM binding site; other site 693216001181 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 693216001182 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693216001183 putative active site [active] 693216001184 heme pocket [chemical binding]; other site 693216001185 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693216001186 dimer interface [polypeptide binding]; other site 693216001187 phosphorylation site [posttranslational modification] 693216001188 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693216001189 ATP binding site [chemical binding]; other site 693216001190 Mg2+ binding site [ion binding]; other site 693216001191 G-X-G motif; other site 693216001192 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693216001193 active site 693216001194 phosphorylation site [posttranslational modification] 693216001195 intermolecular recognition site; other site 693216001196 dimerization interface [polypeptide binding]; other site 693216001197 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 693216001198 putative binding surface; other site 693216001199 active site 693216001200 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 693216001201 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 693216001202 conserved cys residue [active] 693216001203 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 693216001204 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 693216001205 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 693216001206 dimerization domain swap beta strand [polypeptide binding]; other site 693216001207 regulatory protein interface [polypeptide binding]; other site 693216001208 active site 693216001209 regulatory phosphorylation site [posttranslational modification]; other site 693216001210 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 693216001211 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 693216001212 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 693216001213 active site 693216001214 phosphorylation site [posttranslational modification] 693216001215 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 693216001216 30S subunit binding site; other site 693216001217 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 693216001218 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 693216001219 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 693216001220 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 693216001221 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 693216001222 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 693216001223 Walker A/P-loop; other site 693216001224 ATP binding site [chemical binding]; other site 693216001225 Q-loop/lid; other site 693216001226 ABC transporter signature motif; other site 693216001227 Walker B; other site 693216001228 D-loop; other site 693216001229 H-loop/switch region; other site 693216001230 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 693216001231 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 693216001232 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 693216001233 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 693216001234 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 693216001235 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 693216001236 putative active site [active] 693216001237 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 693216001238 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 693216001239 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 693216001240 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 693216001241 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 693216001242 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 693216001243 Walker A/P-loop; other site 693216001244 ATP binding site [chemical binding]; other site 693216001245 Q-loop/lid; other site 693216001246 ABC transporter signature motif; other site 693216001247 Walker B; other site 693216001248 D-loop; other site 693216001249 H-loop/switch region; other site 693216001250 conserved hypothetical integral membrane protein; Region: TIGR00056 693216001251 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 693216001252 mce related protein; Region: MCE; pfam02470 693216001253 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 693216001254 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 693216001255 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 693216001256 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 693216001257 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 693216001258 hinge; other site 693216001259 active site 693216001260 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 693216001261 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 693216001262 substrate binding pocket [chemical binding]; other site 693216001263 chain length determination region; other site 693216001264 substrate-Mg2+ binding site; other site 693216001265 catalytic residues [active] 693216001266 aspartate-rich region 1; other site 693216001267 active site lid residues [active] 693216001268 aspartate-rich region 2; other site 693216001269 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 693216001270 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 693216001271 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 693216001272 EamA-like transporter family; Region: EamA; pfam00892 693216001273 EamA-like transporter family; Region: EamA; pfam00892 693216001274 GTPase CgtA; Reviewed; Region: obgE; PRK12298 693216001275 GTP1/OBG; Region: GTP1_OBG; pfam01018 693216001276 Obg GTPase; Region: Obg; cd01898 693216001277 G1 box; other site 693216001278 GTP/Mg2+ binding site [chemical binding]; other site 693216001279 Switch I region; other site 693216001280 G2 box; other site 693216001281 G3 box; other site 693216001282 Switch II region; other site 693216001283 G4 box; other site 693216001284 G5 box; other site 693216001285 sensor protein BasS/PmrB; Provisional; Region: PRK10755 693216001286 HAMP domain; Region: HAMP; pfam00672 693216001287 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693216001288 dimer interface [polypeptide binding]; other site 693216001289 phosphorylation site [posttranslational modification] 693216001290 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693216001291 ATP binding site [chemical binding]; other site 693216001292 Mg2+ binding site [ion binding]; other site 693216001293 G-X-G motif; other site 693216001294 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 693216001295 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693216001296 active site 693216001297 phosphorylation site [posttranslational modification] 693216001298 intermolecular recognition site; other site 693216001299 dimerization interface [polypeptide binding]; other site 693216001300 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693216001301 DNA binding site [nucleotide binding] 693216001302 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 693216001303 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 693216001304 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 693216001305 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 693216001306 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 693216001307 RNA-binding protein YhbY; Provisional; Region: PRK10343 693216001308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693216001309 S-adenosylmethionine binding site [chemical binding]; other site 693216001310 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 693216001311 FtsH Extracellular; Region: FtsH_ext; pfam06480 693216001312 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693216001313 Walker A motif; other site 693216001314 ATP binding site [chemical binding]; other site 693216001315 Walker B motif; other site 693216001316 arginine finger; other site 693216001317 Peptidase family M41; Region: Peptidase_M41; pfam01434 693216001318 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 693216001319 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 693216001320 substrate binding pocket [chemical binding]; other site 693216001321 dimer interface [polypeptide binding]; other site 693216001322 inhibitor binding site; inhibition site 693216001323 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 693216001324 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 693216001325 active site 693216001326 substrate binding site [chemical binding]; other site 693216001327 metal binding site [ion binding]; metal-binding site 693216001328 Preprotein translocase SecG subunit; Region: SecG; pfam03840 693216001329 Sm and related proteins; Region: Sm_like; cl00259 693216001330 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 693216001331 putative oligomer interface [polypeptide binding]; other site 693216001332 putative RNA binding site [nucleotide binding]; other site 693216001333 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 693216001334 NusA N-terminal domain; Region: NusA_N; pfam08529 693216001335 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 693216001336 RNA binding site [nucleotide binding]; other site 693216001337 homodimer interface [polypeptide binding]; other site 693216001338 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 693216001339 G-X-X-G motif; other site 693216001340 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 693216001341 G-X-X-G motif; other site 693216001342 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 693216001343 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 693216001344 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 693216001345 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 693216001346 translation initiation factor IF-2; Validated; Region: infB; PRK05306 693216001347 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 693216001348 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 693216001349 G1 box; other site 693216001350 putative GEF interaction site [polypeptide binding]; other site 693216001351 GTP/Mg2+ binding site [chemical binding]; other site 693216001352 Switch I region; other site 693216001353 G2 box; other site 693216001354 G3 box; other site 693216001355 Switch II region; other site 693216001356 G4 box; other site 693216001357 G5 box; other site 693216001358 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 693216001359 Translation-initiation factor 2; Region: IF-2; pfam11987 693216001360 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 693216001361 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 693216001362 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 693216001363 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 693216001364 RNA binding site [nucleotide binding]; other site 693216001365 active site 693216001366 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 693216001367 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 693216001368 16S/18S rRNA binding site [nucleotide binding]; other site 693216001369 S13e-L30e interaction site [polypeptide binding]; other site 693216001370 25S rRNA binding site [nucleotide binding]; other site 693216001371 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 693216001372 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 693216001373 RNase E interface [polypeptide binding]; other site 693216001374 trimer interface [polypeptide binding]; other site 693216001375 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 693216001376 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 693216001377 RNase E interface [polypeptide binding]; other site 693216001378 trimer interface [polypeptide binding]; other site 693216001379 active site 693216001380 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 693216001381 putative nucleic acid binding region [nucleotide binding]; other site 693216001382 G-X-X-G motif; other site 693216001383 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 693216001384 RNA binding site [nucleotide binding]; other site 693216001385 domain interface; other site 693216001386 lipoprotein NlpI; Provisional; Region: PRK11189 693216001387 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693216001388 binding surface 693216001389 TPR motif; other site 693216001390 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 693216001391 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 693216001392 ATP binding site [chemical binding]; other site 693216001393 Mg++ binding site [ion binding]; other site 693216001394 motif III; other site 693216001395 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693216001396 nucleotide binding region [chemical binding]; other site 693216001397 ATP-binding site [chemical binding]; other site 693216001398 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 693216001399 putative RNA binding site [nucleotide binding]; other site 693216001400 tryptophan permease; Provisional; Region: PRK10483 693216001401 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 693216001402 hypothetical protein; Provisional; Region: PRK10508 693216001403 putative protease; Provisional; Region: PRK15447 693216001404 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 693216001405 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 693216001406 putative acetyltransferase; Provisional; Region: PRK03624 693216001407 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693216001408 Coenzyme A binding pocket [chemical binding]; other site 693216001409 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 693216001410 GIY-YIG motif/motif A; other site 693216001411 putative active site [active] 693216001412 putative metal binding site [ion binding]; other site 693216001413 hypothetical protein; Provisional; Region: PRK03467 693216001414 intracellular protease, PfpI family; Region: PfpI; TIGR01382 693216001415 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 693216001416 proposed catalytic triad [active] 693216001417 conserved cys residue [active] 693216001418 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 693216001419 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693216001420 NAD(P) binding site [chemical binding]; other site 693216001421 active site 693216001422 Predicted permease; Region: DUF318; cl17795 693216001423 outer membrane lipoprotein; Provisional; Region: PRK11023 693216001424 BON domain; Region: BON; pfam04972 693216001425 BON domain; Region: BON; pfam04972 693216001426 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 693216001427 dimer interface [polypeptide binding]; other site 693216001428 active site 693216001429 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 693216001430 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 693216001431 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 693216001432 putative ligand binding site [chemical binding]; other site 693216001433 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 693216001434 putative SAM binding site [chemical binding]; other site 693216001435 putative homodimer interface [polypeptide binding]; other site 693216001436 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 693216001437 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 693216001438 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 693216001439 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 693216001440 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 693216001441 putative NAD(P) binding site [chemical binding]; other site 693216001442 catalytic Zn binding site [ion binding]; other site 693216001443 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 693216001444 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 693216001445 active site 693216001446 P-loop; other site 693216001447 phosphorylation site [posttranslational modification] 693216001448 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 693216001449 active site 693216001450 phosphorylation site [posttranslational modification] 693216001451 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 693216001452 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 693216001453 intersubunit interface [polypeptide binding]; other site 693216001454 active site 693216001455 zinc binding site [ion binding]; other site 693216001456 Na+ binding site [ion binding]; other site 693216001457 Pirin-related protein [General function prediction only]; Region: COG1741 693216001458 Pirin; Region: Pirin; pfam02678 693216001459 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216001460 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 693216001461 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693216001462 dimerization interface [polypeptide binding]; other site 693216001463 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 693216001464 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693216001465 DNA binding site [nucleotide binding] 693216001466 domain linker motif; other site 693216001467 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 693216001468 dimerization interface [polypeptide binding]; other site 693216001469 ligand binding site [chemical binding]; other site 693216001470 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 693216001471 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 693216001472 substrate binding [chemical binding]; other site 693216001473 active site 693216001474 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 693216001475 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 693216001476 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 693216001477 active site turn [active] 693216001478 phosphorylation site [posttranslational modification] 693216001479 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 693216001480 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 693216001481 maltoporin; Provisional; Region: lamB; PRK09360 693216001482 trimer interface; other site 693216001483 sugar binding site [chemical binding]; other site 693216001484 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 693216001485 putative substrate binding site [chemical binding]; other site 693216001486 putative ATP binding site [chemical binding]; other site 693216001487 Protein of unknown function (DUF805); Region: DUF805; pfam05656 693216001488 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 693216001489 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 693216001490 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 693216001491 putative dimer interface [polypeptide binding]; other site 693216001492 N-terminal domain interface [polypeptide binding]; other site 693216001493 putative substrate binding pocket (H-site) [chemical binding]; other site 693216001494 Predicted membrane protein [Function unknown]; Region: COG2259 693216001495 YqjK-like protein; Region: YqjK; pfam13997 693216001496 Predicted membrane protein [Function unknown]; Region: COG5393 693216001497 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 693216001498 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 693216001499 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 693216001500 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 693216001501 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 693216001502 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693216001503 DNA-binding site [nucleotide binding]; DNA binding site 693216001504 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 693216001505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216001506 D-galactonate transporter; Region: 2A0114; TIGR00893 693216001507 putative substrate translocation pore; other site 693216001508 glucuronate isomerase; Reviewed; Region: PRK02925 693216001509 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 693216001510 galactarate dehydratase; Region: galactar-dH20; TIGR03248 693216001511 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 693216001512 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 693216001513 serine/threonine transporter SstT; Provisional; Region: PRK13628 693216001514 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 693216001515 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 693216001516 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693216001517 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 693216001518 putative active site [active] 693216001519 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 693216001520 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 693216001521 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693216001522 S-adenosylmethionine binding site [chemical binding]; other site 693216001523 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 693216001524 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 693216001525 active site 693216001526 FMN binding site [chemical binding]; other site 693216001527 2,4-decadienoyl-CoA binding site; other site 693216001528 catalytic residue [active] 693216001529 4Fe-4S cluster binding site [ion binding]; other site 693216001530 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 693216001531 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693216001532 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 693216001533 inhibitor-cofactor binding pocket; inhibition site 693216001534 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216001535 catalytic residue [active] 693216001536 diguanylate cyclase; Provisional; Region: PRK09894 693216001537 Chemoreceptor zinc-binding domain; Region: CZB; pfam13682 693216001538 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693216001539 metal binding site [ion binding]; metal-binding site 693216001540 active site 693216001541 I-site; other site 693216001542 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693216001543 PAS fold; Region: PAS_3; pfam08447 693216001544 putative active site [active] 693216001545 heme pocket [chemical binding]; other site 693216001546 HAMP domain; Region: HAMP; pfam00672 693216001547 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693216001548 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693216001549 dimer interface [polypeptide binding]; other site 693216001550 putative CheW interface [polypeptide binding]; other site 693216001551 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 693216001552 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 693216001553 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693216001554 dimerization interface [polypeptide binding]; other site 693216001555 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693216001556 dimer interface [polypeptide binding]; other site 693216001557 putative CheW interface [polypeptide binding]; other site 693216001558 Predicted transcriptional regulators [Transcription]; Region: COG1695 693216001559 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 693216001560 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 693216001561 FAD binding pocket [chemical binding]; other site 693216001562 FAD binding motif [chemical binding]; other site 693216001563 phosphate binding motif [ion binding]; other site 693216001564 NAD binding pocket [chemical binding]; other site 693216001565 hypothetical protein; Provisional; Region: PRK01254 693216001566 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 693216001567 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 693216001568 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 693216001569 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 693216001570 homotrimer interaction site [polypeptide binding]; other site 693216001571 putative active site [active] 693216001572 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 693216001573 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 693216001574 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 693216001575 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 693216001576 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 693216001577 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 693216001578 Arginine repressor [Transcription]; Region: ArgR; COG1438 693216001579 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 693216001580 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 693216001581 Predicted membrane protein [Function unknown]; Region: COG1288 693216001582 ornithine carbamoyltransferase; Validated; Region: PRK02102 693216001583 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 693216001584 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 693216001585 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 693216001586 putative substrate binding site [chemical binding]; other site 693216001587 nucleotide binding site [chemical binding]; other site 693216001588 nucleotide binding site [chemical binding]; other site 693216001589 homodimer interface [polypeptide binding]; other site 693216001590 arginine deiminase; Provisional; Region: PRK01388 693216001591 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 693216001592 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 693216001593 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 693216001594 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 693216001595 RNase E inhibitor protein; Provisional; Region: PRK11191 693216001596 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 693216001597 active site 693216001598 dinuclear metal binding site [ion binding]; other site 693216001599 dimerization interface [polypeptide binding]; other site 693216001600 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 693216001601 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693216001602 Coenzyme A binding pocket [chemical binding]; other site 693216001603 Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987 693216001604 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 693216001605 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 693216001606 active site 693216001607 HIGH motif; other site 693216001608 KMSKS motif; other site 693216001609 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 693216001610 tRNA binding surface [nucleotide binding]; other site 693216001611 anticodon binding site; other site 693216001612 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 693216001613 DNA polymerase III subunit chi; Validated; Region: PRK05728 693216001614 multifunctional aminopeptidase A; Provisional; Region: PRK00913 693216001615 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 693216001616 interface (dimer of trimers) [polypeptide binding]; other site 693216001617 Substrate-binding/catalytic site; other site 693216001618 Zn-binding sites [ion binding]; other site 693216001619 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 693216001620 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 693216001621 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 693216001622 dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361 693216001623 Dak1 domain; Region: Dak1; cl10557 693216001624 DAK2 domain; Region: Dak2; pfam02734 693216001625 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 693216001626 Zn binding sites [ion binding]; other site 693216001627 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 693216001628 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 693216001629 putative NAD(P) binding site [chemical binding]; other site 693216001630 putative substrate binding site [chemical binding]; other site 693216001631 catalytic Zn binding site [ion binding]; other site 693216001632 structural Zn binding site [ion binding]; other site 693216001633 dimer interface [polypeptide binding]; other site 693216001634 Protein of unknown function (DUF2589); Region: DUF2589; pfam11655 693216001635 Protein of unknown function (DUF2589); Region: DUF2589; pfam11655 693216001636 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 693216001637 catalytic residues [active] 693216001638 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 693216001639 active site 693216001640 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 693216001641 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693216001642 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693216001643 DNA binding residues [nucleotide binding] 693216001644 dimerization interface [polypeptide binding]; other site 693216001645 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693216001646 S-adenosylmethionine binding site [chemical binding]; other site 693216001647 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 693216001648 active site 693216001649 DNA phosphorothioation-dependent restriction protein DptF; Region: dnd_assoc_3; TIGR03238 693216001650 DNA phosphorothioation-dependent restriction protein DptG; Region: dnd_assoc_1; TIGR03236 693216001651 DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237 693216001652 AAA-like domain; Region: AAA_10; pfam12846 693216001653 Domain of unknown function DUF87; Region: DUF87; cl19135 693216001654 DNA phosphorothioation-associated DGQHR protein 1; Region: DGQHR_dnd_1; TIGR04172 693216001655 Domain of unknown function (DUF1832); Region: DUF1832; pfam08870 693216001656 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 693216001657 AAA domain; Region: AAA_23; pfam13476 693216001658 Walker A/P-loop; other site 693216001659 ATP binding site [chemical binding]; other site 693216001660 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693216001661 ABC transporter signature motif; other site 693216001662 Walker B; other site 693216001663 D-loop; other site 693216001664 H-loop/switch region; other site 693216001665 hypothetical protein; Provisional; Region: PRK06850 693216001666 Ligand Binding Site [chemical binding]; other site 693216001667 DNA-sulfur modification-associated; Region: DndB; pfam14072 693216001668 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 693216001669 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693216001670 non-specific DNA binding site [nucleotide binding]; other site 693216001671 salt bridge; other site 693216001672 sequence-specific DNA binding site [nucleotide binding]; other site 693216001673 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 693216001674 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 693216001675 dimer interface [polypeptide binding]; other site 693216001676 active site 693216001677 metal binding site [ion binding]; metal-binding site 693216001678 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 693216001679 Predicted membrane protein [Function unknown]; Region: COG2733 693216001680 Protein of unknown function (DUF445); Region: DUF445; pfam04286 693216001681 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 693216001682 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693216001683 DNA-binding site [nucleotide binding]; DNA binding site 693216001684 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693216001685 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216001686 homodimer interface [polypeptide binding]; other site 693216001687 catalytic residue [active] 693216001688 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 693216001689 endoribonuclease SymE; Provisional; Region: PRK13605 693216001690 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 693216001691 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 693216001692 Walker A/P-loop; other site 693216001693 ATP binding site [chemical binding]; other site 693216001694 Q-loop/lid; other site 693216001695 ABC transporter signature motif; other site 693216001696 Walker B; other site 693216001697 D-loop; other site 693216001698 H-loop/switch region; other site 693216001699 TOBE domain; Region: TOBE; pfam03459 693216001700 TOBE domain; Region: TOBE_2; pfam08402 693216001701 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 693216001702 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 693216001703 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 693216001704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216001705 dimer interface [polypeptide binding]; other site 693216001706 conserved gate region; other site 693216001707 putative PBP binding loops; other site 693216001708 ABC-ATPase subunit interface; other site 693216001709 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 693216001710 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216001711 dimer interface [polypeptide binding]; other site 693216001712 conserved gate region; other site 693216001713 putative PBP binding loops; other site 693216001714 ABC-ATPase subunit interface; other site 693216001715 Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism]; Region: COG3867 693216001716 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 693216001717 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 693216001718 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 693216001719 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 693216001720 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 693216001721 active site turn [active] 693216001722 phosphorylation site [posttranslational modification] 693216001723 maltoporin; Provisional; Region: lamB; PRK09360 693216001724 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 693216001725 trimer interface; other site 693216001726 sugar binding site [chemical binding]; other site 693216001727 PgaD-like protein; Region: PgaD; cl14676 693216001728 lac repressor; Reviewed; Region: lacI; PRK09526 693216001729 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693216001730 DNA binding site [nucleotide binding] 693216001731 domain linker motif; other site 693216001732 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 693216001733 ligand binding site [chemical binding]; other site 693216001734 dimerization interface (open form) [polypeptide binding]; other site 693216001735 dimerization interface (closed form) [polypeptide binding]; other site 693216001736 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 693216001737 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693216001738 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 693216001739 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693216001740 Snf7; Region: Snf7; cl19390 693216001741 HlyD family secretion protein; Region: HlyD_3; pfam13437 693216001742 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 693216001743 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693216001744 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693216001745 DNA binding site [nucleotide binding] 693216001746 domain linker motif; other site 693216001747 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 693216001748 dimerization interface (closed form) [polypeptide binding]; other site 693216001749 ligand binding site [chemical binding]; other site 693216001750 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 693216001751 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 693216001752 active site turn [active] 693216001753 phosphorylation site [posttranslational modification] 693216001754 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 693216001755 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 693216001756 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 693216001757 cytosine permease; Provisional; Region: codB; PRK11017 693216001758 Na binding site [ion binding]; other site 693216001759 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 693216001760 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 693216001761 active site 693216001762 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 693216001763 Subtilase family; Region: Peptidase_S8; pfam00082 693216001764 catalytic triad [active] 693216001765 putative active site [active] 693216001766 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 693216001767 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 693216001768 Autotransporter beta-domain; Region: Autotransporter; pfam03797 693216001769 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 693216001770 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 693216001771 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 693216001772 dimer interface [polypeptide binding]; other site 693216001773 ligand binding site [chemical binding]; other site 693216001774 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693216001775 dimerization interface [polypeptide binding]; other site 693216001776 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693216001777 dimer interface [polypeptide binding]; other site 693216001778 putative CheW interface [polypeptide binding]; other site 693216001779 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693216001780 dimerization interface [polypeptide binding]; other site 693216001781 GAF domain; Region: GAF_3; pfam13492 693216001782 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693216001783 metal binding site [ion binding]; metal-binding site 693216001784 active site 693216001785 I-site; other site 693216001786 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 693216001787 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693216001788 metal binding site [ion binding]; metal-binding site 693216001789 active site 693216001790 I-site; other site 693216001791 phosphoglycerol transferase I; Provisional; Region: PRK03776 693216001792 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 693216001793 DNA replication protein DnaC; Validated; Region: PRK07952 693216001794 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693216001795 Walker A motif; other site 693216001796 ATP binding site [chemical binding]; other site 693216001797 Walker B motif; other site 693216001798 primosomal protein DnaI; Provisional; Region: PRK02854 693216001799 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 693216001800 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693216001801 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 693216001802 putative Zn2+ binding site [ion binding]; other site 693216001803 putative DNA binding site [nucleotide binding]; other site 693216001804 hypothetical protein; Provisional; Region: PRK09917 693216001805 Uncharacterized conserved protein [Function unknown]; Region: COG2966 693216001806 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 693216001807 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693216001808 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693216001809 DNA binding residues [nucleotide binding] 693216001810 dimerization interface [polypeptide binding]; other site 693216001811 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 693216001812 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693216001813 DNA binding residues [nucleotide binding] 693216001814 dimerization interface [polypeptide binding]; other site 693216001815 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 693216001816 putative deacylase active site [active] 693216001817 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 693216001818 Uncharacterized Fe-S protein [General function prediction only]; Region: FhuF; COG4114 693216001819 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 693216001820 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 693216001821 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693216001822 metal binding site [ion binding]; metal-binding site 693216001823 active site 693216001824 I-site; other site 693216001825 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 693216001826 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 693216001827 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 693216001828 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693216001829 S-adenosylmethionine binding site [chemical binding]; other site 693216001830 DNA polymerase III psi subunit; Region: DNA_III_psi; pfam03603 693216001831 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 693216001832 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693216001833 Coenzyme A binding pocket [chemical binding]; other site 693216001834 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 693216001835 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 693216001836 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693216001837 motif II; other site 693216001838 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 693216001839 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 693216001840 G1 box; other site 693216001841 putative GEF interaction site [polypeptide binding]; other site 693216001842 GTP/Mg2+ binding site [chemical binding]; other site 693216001843 Switch I region; other site 693216001844 G2 box; other site 693216001845 G3 box; other site 693216001846 Switch II region; other site 693216001847 G4 box; other site 693216001848 G5 box; other site 693216001849 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 693216001850 periplasmic protein; Provisional; Region: PRK10568 693216001851 BON domain; Region: BON; pfam04972 693216001852 BON domain; Region: BON; pfam04972 693216001853 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 693216001854 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 693216001855 active site 693216001856 nucleophile elbow; other site 693216001857 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 693216001858 active site 693216001859 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 693216001860 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 693216001861 Nucleoside recognition; Region: Gate; pfam07670 693216001862 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 693216001863 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 693216001864 intersubunit interface [polypeptide binding]; other site 693216001865 active site 693216001866 catalytic residue [active] 693216001867 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 693216001868 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 693216001869 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 693216001870 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 693216001871 phosphopentomutase; Provisional; Region: PRK05362 693216001872 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 693216001873 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 693216001874 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 693216001875 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 693216001876 hypothetical protein; Provisional; Region: PRK11246 693216001877 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 693216001878 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693216001879 motif II; other site 693216001880 DNA repair protein RadA; Region: sms; TIGR00416 693216001881 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 693216001882 Walker A motif/ATP binding site; other site 693216001883 ATP binding site [chemical binding]; other site 693216001884 Walker B motif; other site 693216001885 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 693216001886 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693216001887 non-specific DNA binding site [nucleotide binding]; other site 693216001888 salt bridge; other site 693216001889 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 693216001890 sequence-specific DNA binding site [nucleotide binding]; other site 693216001891 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 693216001892 active site 693216001893 (T/H)XGH motif; other site 693216001894 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 693216001895 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 693216001896 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 693216001897 putative NAD(P) binding site [chemical binding]; other site 693216001898 dimer interface [polypeptide binding]; other site 693216001899 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693216001900 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216001901 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693216001902 putative effector binding pocket; other site 693216001903 dimerization interface [polypeptide binding]; other site 693216001904 ABC-2 type transporter; Region: ABC2_membrane; cl17235 693216001905 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 693216001906 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 693216001907 Walker A/P-loop; other site 693216001908 ATP binding site [chemical binding]; other site 693216001909 Q-loop/lid; other site 693216001910 ABC transporter signature motif; other site 693216001911 Walker B; other site 693216001912 D-loop; other site 693216001913 H-loop/switch region; other site 693216001914 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 693216001915 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 693216001916 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 693216001917 active site 693216001918 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; cl19502 693216001919 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 693216001920 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 693216001921 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 693216001922 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 693216001923 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 693216001924 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 693216001925 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 693216001926 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 693216001927 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 693216001928 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 693216001929 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 693216001930 Chain length determinant protein; Region: Wzz; cl19730 693216001931 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 693216001932 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693216001933 ABC transporter; Region: ABC_tran_2; pfam12848 693216001934 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693216001935 lytic murein transglycosylase; Provisional; Region: PRK11619 693216001936 Soluble lytic murein transglycosylase L domain; Region: SLT_L; pfam14718 693216001937 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693216001938 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693216001939 catalytic residue [active] 693216001940 Trp operon repressor; Provisional; Region: PRK01381 693216001941 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 693216001942 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 693216001943 catalytic core [active] 693216001944 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 693216001945 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693216001946 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693216001947 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 693216001948 hypothetical protein; Provisional; Region: PRK10756 693216001949 DNA-binding response regulator CreB; Provisional; Region: PRK11083 693216001950 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693216001951 active site 693216001952 phosphorylation site [posttranslational modification] 693216001953 intermolecular recognition site; other site 693216001954 dimerization interface [polypeptide binding]; other site 693216001955 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693216001956 DNA binding site [nucleotide binding] 693216001957 sensory histidine kinase CreC; Provisional; Region: PRK11100 693216001958 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693216001959 dimerization interface [polypeptide binding]; other site 693216001960 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693216001961 dimer interface [polypeptide binding]; other site 693216001962 phosphorylation site [posttranslational modification] 693216001963 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693216001964 ATP binding site [chemical binding]; other site 693216001965 Mg2+ binding site [ion binding]; other site 693216001966 G-X-G motif; other site 693216001967 inner membrane protein; Provisional; Region: PRK11715 693216001968 two-component response regulator; Provisional; Region: PRK11173 693216001969 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693216001970 active site 693216001971 phosphorylation site [posttranslational modification] 693216001972 intermolecular recognition site; other site 693216001973 dimerization interface [polypeptide binding]; other site 693216001974 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693216001975 DNA binding site [nucleotide binding] 693216001976 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 693216001977 putative RNA methyltransferase; Provisional; Region: PRK10433 693216001978 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 693216001979 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 693216001980 putative catalytic residues [active] 693216001981 putative nucleotide binding site [chemical binding]; other site 693216001982 putative aspartate binding site [chemical binding]; other site 693216001983 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 693216001984 dimer interface [polypeptide binding]; other site 693216001985 putative threonine allosteric regulatory site; other site 693216001986 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 693216001987 putative threonine allosteric regulatory site; other site 693216001988 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 693216001989 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 693216001990 homoserine kinase; Provisional; Region: PRK01212 693216001991 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 693216001992 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 693216001993 threonine synthase; Validated; Region: PRK09225 693216001994 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 693216001995 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693216001996 catalytic residue [active] 693216001997 hypothetical protein; Validated; Region: PRK02101 693216001998 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 693216001999 transaldolase-like protein; Provisional; Region: PTZ00411 693216002000 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 693216002001 active site 693216002002 dimer interface [polypeptide binding]; other site 693216002003 catalytic residue [active] 693216002004 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 693216002005 MPT binding site; other site 693216002006 trimer interface [polypeptide binding]; other site 693216002007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216002008 metabolite-proton symporter; Region: 2A0106; TIGR00883 693216002009 putative substrate translocation pore; other site 693216002010 hypothetical protein; Provisional; Region: PRK10659 693216002011 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 693216002012 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 693216002013 nucleotide binding site [chemical binding]; other site 693216002014 chaperone protein DnaJ; Provisional; Region: PRK10767 693216002015 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 693216002016 HSP70 interaction site [polypeptide binding]; other site 693216002017 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 693216002018 substrate binding site [polypeptide binding]; other site 693216002019 dimer interface [polypeptide binding]; other site 693216002020 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693216002021 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216002022 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693216002023 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 693216002024 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 693216002025 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 693216002026 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 693216002027 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 693216002028 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 693216002029 active site 693216002030 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 693216002031 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 693216002032 aromatic chitin/cellulose binding site residues [chemical binding]; other site 693216002033 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 693216002034 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 693216002035 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216002036 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 693216002037 putative dimerization interface [polypeptide binding]; other site 693216002038 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 693216002039 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 693216002040 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 693216002041 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 693216002042 active site 693216002043 Riboflavin kinase; Region: Flavokinase; smart00904 693216002044 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 693216002045 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 693216002046 active site 693216002047 HIGH motif; other site 693216002048 KMSKS motif; other site 693216002049 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 693216002050 tRNA binding surface [nucleotide binding]; other site 693216002051 anticodon binding site; other site 693216002052 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 693216002053 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 693216002054 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 693216002055 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 693216002056 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 693216002057 Fe-S cluster binding site [ion binding]; other site 693216002058 substrate binding site [chemical binding]; other site 693216002059 catalytic site [active] 693216002060 short chain dehydrogenase; Provisional; Region: PRK07063 693216002061 classical (c) SDRs; Region: SDR_c; cd05233 693216002062 NAD(P) binding site [chemical binding]; other site 693216002063 active site 693216002064 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 693216002065 inhibitor site; inhibition site 693216002066 active site 693216002067 dimer interface [polypeptide binding]; other site 693216002068 catalytic residue [active] 693216002069 Dehydratase family; Region: ILVD_EDD; pfam00920 693216002070 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 693216002071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216002072 putative substrate translocation pore; other site 693216002073 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 693216002074 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216002075 putative substrate translocation pore; other site 693216002076 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 693216002077 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 693216002078 active site 693216002079 intersubunit interface [polypeptide binding]; other site 693216002080 catalytic residue [active] 693216002081 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 693216002082 Transcriptional regulators [Transcription]; Region: FadR; COG2186 693216002083 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693216002084 DNA-binding site [nucleotide binding]; DNA binding site 693216002085 FCD domain; Region: FCD; pfam07729 693216002086 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 693216002087 active site 693216002088 tetramer interface [polypeptide binding]; other site 693216002089 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693216002090 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216002091 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693216002092 putative effector binding pocket; other site 693216002093 dimerization interface [polypeptide binding]; other site 693216002094 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 693216002095 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 693216002096 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 693216002097 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 693216002098 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 693216002099 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 693216002100 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 693216002101 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 693216002102 catalytic site [active] 693216002103 subunit interface [polypeptide binding]; other site 693216002104 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 693216002105 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 693216002106 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 693216002107 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 693216002108 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 693216002109 ATP-grasp domain; Region: ATP-grasp_4; cl17255 693216002110 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 693216002111 IMP binding site; other site 693216002112 dimer interface [polypeptide binding]; other site 693216002113 interdomain contacts; other site 693216002114 partial ornithine binding site; other site 693216002115 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 693216002116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 693216002117 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 693216002118 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 693216002119 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 693216002120 TrkA-N domain; Region: TrkA_N; pfam02254 693216002121 LysE type translocator; Region: LysE; cl00565 693216002122 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 693216002123 folate binding site [chemical binding]; other site 693216002124 NADP+ binding site [chemical binding]; other site 693216002125 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 693216002126 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 693216002127 active site 693216002128 metal binding site [ion binding]; metal-binding site 693216002129 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 693216002130 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 693216002131 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 693216002132 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 693216002133 SurA N-terminal domain; Region: SurA_N; pfam09312 693216002134 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 693216002135 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 693216002136 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 693216002137 OstA-like protein; Region: OstA; pfam03968 693216002138 Organic solvent tolerance protein; Region: OstA_C; pfam04453 693216002139 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 693216002140 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 693216002141 putative metal binding site [ion binding]; other site 693216002142 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 693216002143 HSP70 interaction site [polypeptide binding]; other site 693216002144 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 693216002145 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 693216002146 active site 693216002147 ATP-dependent helicase HepA; Validated; Region: PRK04914 693216002148 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693216002149 ATP binding site [chemical binding]; other site 693216002150 putative Mg++ binding site [ion binding]; other site 693216002151 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693216002152 nucleotide binding region [chemical binding]; other site 693216002153 ATP-binding site [chemical binding]; other site 693216002154 RNA polymerase recycling family C-terminal; Region: RapA_C; pfam12137 693216002155 DNA polymerase II; Reviewed; Region: PRK05762 693216002156 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 693216002157 active site 693216002158 catalytic site [active] 693216002159 substrate binding site [chemical binding]; other site 693216002160 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 693216002161 active site 693216002162 metal-binding site 693216002163 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 693216002164 intersubunit interface [polypeptide binding]; other site 693216002165 active site 693216002166 Zn2+ binding site [ion binding]; other site 693216002167 L-arabinose isomerase; Provisional; Region: PRK02929 693216002168 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 693216002169 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 693216002170 trimer interface [polypeptide binding]; other site 693216002171 putative substrate binding site [chemical binding]; other site 693216002172 putative metal binding site [ion binding]; other site 693216002173 ribulokinase; Provisional; Region: PRK04123 693216002174 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 693216002175 N- and C-terminal domain interface [polypeptide binding]; other site 693216002176 active site 693216002177 MgATP binding site [chemical binding]; other site 693216002178 catalytic site [active] 693216002179 metal binding site [ion binding]; metal-binding site 693216002180 carbohydrate binding site [chemical binding]; other site 693216002181 homodimer interface [polypeptide binding]; other site 693216002182 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 693216002183 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 693216002184 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693216002185 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693216002186 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 693216002187 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 693216002188 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693216002189 Walker A/P-loop; other site 693216002190 ATP binding site [chemical binding]; other site 693216002191 Q-loop/lid; other site 693216002192 ABC transporter signature motif; other site 693216002193 Walker B; other site 693216002194 D-loop; other site 693216002195 H-loop/switch region; other site 693216002196 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 693216002197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216002198 dimer interface [polypeptide binding]; other site 693216002199 conserved gate region; other site 693216002200 putative PBP binding loops; other site 693216002201 ABC-ATPase subunit interface; other site 693216002202 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216002203 dimer interface [polypeptide binding]; other site 693216002204 conserved gate region; other site 693216002205 putative PBP binding loops; other site 693216002206 ABC-ATPase subunit interface; other site 693216002207 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 693216002208 transcriptional regulator SgrR; Provisional; Region: PRK13626 693216002209 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 693216002210 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 693216002211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216002212 sugar efflux transporter; Region: 2A0120; TIGR00899 693216002213 putative substrate translocation pore; other site 693216002214 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 693216002215 substrate binding site [chemical binding]; other site 693216002216 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 693216002217 substrate binding site [chemical binding]; other site 693216002218 ligand binding site [chemical binding]; other site 693216002219 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 693216002220 2-isopropylmalate synthase; Validated; Region: PRK00915 693216002221 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 693216002222 active site 693216002223 catalytic residues [active] 693216002224 metal binding site [ion binding]; metal-binding site 693216002225 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 693216002226 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 693216002227 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216002228 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 693216002229 putative substrate binding pocket [chemical binding]; other site 693216002230 putative dimerization interface [polypeptide binding]; other site 693216002231 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 693216002232 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 693216002233 PYR/PP interface [polypeptide binding]; other site 693216002234 dimer interface [polypeptide binding]; other site 693216002235 TPP binding site [chemical binding]; other site 693216002236 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 693216002237 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 693216002238 TPP-binding site [chemical binding]; other site 693216002239 dimer interface [polypeptide binding]; other site 693216002240 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 693216002241 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 693216002242 putative valine binding site [chemical binding]; other site 693216002243 dimer interface [polypeptide binding]; other site 693216002244 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 693216002245 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 693216002246 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693216002247 DNA binding site [nucleotide binding] 693216002248 domain linker motif; other site 693216002249 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 693216002250 dimerization interface [polypeptide binding]; other site 693216002251 ligand binding site [chemical binding]; other site 693216002252 mraZ protein; Region: TIGR00242 693216002253 MraZ protein; Region: MraZ; pfam02381 693216002254 MraZ protein; Region: MraZ; pfam02381 693216002255 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 693216002256 cell division protein FtsL; Provisional; Region: PRK10772 693216002257 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 693216002258 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 693216002259 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 693216002260 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 693216002261 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 693216002262 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693216002263 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 693216002264 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 693216002265 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 693216002266 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693216002267 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 693216002268 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 693216002269 Mg++ binding site [ion binding]; other site 693216002270 putative catalytic motif [active] 693216002271 putative substrate binding site [chemical binding]; other site 693216002272 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 693216002273 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693216002274 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 693216002275 cell division protein FtsW; Provisional; Region: PRK10774 693216002276 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 693216002277 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 693216002278 active site 693216002279 homodimer interface [polypeptide binding]; other site 693216002280 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 693216002281 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 693216002282 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693216002283 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 693216002284 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 693216002285 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 693216002286 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 693216002287 cell division protein FtsQ; Provisional; Region: PRK10775 693216002288 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 693216002289 Cell division protein FtsQ; Region: FtsQ; pfam03799 693216002290 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 693216002291 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 693216002292 Cell division protein FtsA; Region: FtsA; pfam14450 693216002293 cell division protein FtsZ; Validated; Region: PRK09330 693216002294 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 693216002295 nucleotide binding site [chemical binding]; other site 693216002296 SulA interaction site; other site 693216002297 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 693216002298 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 693216002299 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 693216002300 SecA regulator SecM; Provisional; Region: PRK02943 693216002301 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 693216002302 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 693216002303 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 693216002304 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693216002305 nucleotide binding region [chemical binding]; other site 693216002306 ATP-binding site [chemical binding]; other site 693216002307 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 693216002308 SEC-C motif; Region: SEC-C; pfam02810 693216002309 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 693216002310 active site 693216002311 8-oxo-dGMP binding site [chemical binding]; other site 693216002312 nudix motif; other site 693216002313 metal binding site [ion binding]; metal-binding site 693216002314 DNA gyrase inhibitor; Reviewed; Region: PRK00418 693216002315 hypothetical protein; Provisional; Region: PRK05287 693216002316 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 693216002317 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 693216002318 CoA-binding site [chemical binding]; other site 693216002319 ATP-binding [chemical binding]; other site 693216002320 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 693216002321 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 693216002322 active site 693216002323 type IV pilin biogenesis protein; Provisional; Region: PRK10573 693216002324 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 693216002325 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 693216002326 hypothetical protein; Provisional; Region: PRK10436 693216002327 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 693216002328 Walker A motif; other site 693216002329 ATP binding site [chemical binding]; other site 693216002330 Walker B motif; other site 693216002331 putative major pilin subunit; Provisional; Region: PRK10574 693216002332 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 693216002333 Pilin (bacterial filament); Region: Pilin; pfam00114 693216002334 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 693216002335 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 693216002336 dimerization interface [polypeptide binding]; other site 693216002337 active site 693216002338 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 693216002339 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 693216002340 amidase catalytic site [active] 693216002341 substrate binding site [chemical binding]; other site 693216002342 Zn binding residues [ion binding]; other site 693216002343 regulatory protein AmpE; Provisional; Region: PRK10987 693216002344 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 693216002345 active site 693216002346 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 693216002347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216002348 putative substrate translocation pore; other site 693216002349 aromatic amino acid transporter; Provisional; Region: PRK10238 693216002350 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 693216002351 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 693216002352 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693216002353 DNA-binding site [nucleotide binding]; DNA binding site 693216002354 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 693216002355 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 693216002356 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 693216002357 dimer interface [polypeptide binding]; other site 693216002358 TPP-binding site [chemical binding]; other site 693216002359 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 693216002360 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 693216002361 E3 interaction surface; other site 693216002362 lipoyl attachment site [posttranslational modification]; other site 693216002363 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 693216002364 E3 interaction surface; other site 693216002365 lipoyl attachment site [posttranslational modification]; other site 693216002366 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 693216002367 E3 interaction surface; other site 693216002368 lipoyl attachment site [posttranslational modification]; other site 693216002369 e3 binding domain; Region: E3_binding; pfam02817 693216002370 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 693216002371 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 693216002372 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 693216002373 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693216002374 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 693216002375 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 693216002376 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 693216002377 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 693216002378 Aconitate B N-terminal domain; Region: Aconitase_B_N; pfam11791 693216002379 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 693216002380 substrate binding site [chemical binding]; other site 693216002381 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 693216002382 substrate binding site [chemical binding]; other site 693216002383 ligand binding site [chemical binding]; other site 693216002384 hypothetical protein; Provisional; Region: PRK05248 693216002385 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 693216002386 Methyltransferase domain; Region: Methyltransf_31; pfam13847 693216002387 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693216002388 S-adenosylmethionine binding site [chemical binding]; other site 693216002389 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 693216002390 multicopper oxidase; Provisional; Region: PRK10965 693216002391 The first Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_1_CueO_FtsP; cd04232 693216002392 Domain 2 interface [polypeptide binding]; other site 693216002393 Domain 3 interface [polypeptide binding]; other site 693216002394 trinuclear Cu binding site [ion binding]; other site 693216002395 The second Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_2_CueO_FtsP; cd13867 693216002396 Domain 1 interface [polypeptide binding]; other site 693216002397 Domain 3 interface [polypeptide binding]; other site 693216002398 The third Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_3_CueO_FtsP; cd13890 693216002399 Domain 2 interface [polypeptide binding]; other site 693216002400 Domain 1 interface [polypeptide binding]; other site 693216002401 Type 1 (T1) Cu binding site [ion binding]; other site 693216002402 trinuclear Cu binding site [ion binding]; other site 693216002403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216002404 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 693216002405 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 693216002406 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 693216002407 Trp docking motif [polypeptide binding]; other site 693216002408 putative active site [active] 693216002409 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693216002410 active site 693216002411 chemotaxis protein; Reviewed; Region: PRK12798 693216002412 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 693216002413 active site clefts [active] 693216002414 zinc binding site [ion binding]; other site 693216002415 dimer interface [polypeptide binding]; other site 693216002416 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 693216002417 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693216002418 Walker A/P-loop; other site 693216002419 ATP binding site [chemical binding]; other site 693216002420 Q-loop/lid; other site 693216002421 ABC transporter signature motif; other site 693216002422 Walker B; other site 693216002423 D-loop; other site 693216002424 H-loop/switch region; other site 693216002425 inner membrane transport permease; Provisional; Region: PRK15066 693216002426 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 693216002427 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 693216002428 active pocket/dimerization site; other site 693216002429 active site 693216002430 phosphorylation site [posttranslational modification] 693216002431 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 693216002432 putative active site [active] 693216002433 putative metal binding site [ion binding]; other site 693216002434 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 693216002435 tetramerization interface [polypeptide binding]; other site 693216002436 active site 693216002437 Pantoate-beta-alanine ligase; Region: PanC; cd00560 693216002438 active site 693216002439 ATP-binding site [chemical binding]; other site 693216002440 pantoate-binding site; other site 693216002441 HXXH motif; other site 693216002442 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 693216002443 oligomerization interface [polypeptide binding]; other site 693216002444 active site 693216002445 metal binding site [ion binding]; metal-binding site 693216002446 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 693216002447 catalytic center binding site [active] 693216002448 ATP binding site [chemical binding]; other site 693216002449 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 693216002450 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 693216002451 active site 693216002452 NTP binding site [chemical binding]; other site 693216002453 metal binding triad [ion binding]; metal-binding site 693216002454 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 693216002455 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 693216002456 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 693216002457 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 693216002458 active site 693216002459 nucleotide binding site [chemical binding]; other site 693216002460 HIGH motif; other site 693216002461 KMSKS motif; other site 693216002462 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 693216002463 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 693216002464 2'-5' RNA ligase; Provisional; Region: PRK15124 693216002465 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 693216002466 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 693216002467 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 693216002468 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693216002469 ATP binding site [chemical binding]; other site 693216002470 putative Mg++ binding site [ion binding]; other site 693216002471 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693216002472 nucleotide binding region [chemical binding]; other site 693216002473 ATP-binding site [chemical binding]; other site 693216002474 Helicase associated domain (HA2); Region: HA2; pfam04408 693216002475 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 693216002476 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 693216002477 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 693216002478 Transglycosylase; Region: Transgly; pfam00912 693216002479 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 693216002480 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 693216002481 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693216002482 N-terminal plug; other site 693216002483 ligand-binding site [chemical binding]; other site 693216002484 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 693216002485 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 693216002486 Walker A/P-loop; other site 693216002487 ATP binding site [chemical binding]; other site 693216002488 Q-loop/lid; other site 693216002489 ABC transporter signature motif; other site 693216002490 Walker B; other site 693216002491 D-loop; other site 693216002492 H-loop/switch region; other site 693216002493 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 693216002494 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 693216002495 siderophore binding site; other site 693216002496 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 693216002497 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 693216002498 ABC-ATPase subunit interface; other site 693216002499 dimer interface [polypeptide binding]; other site 693216002500 putative PBP binding regions; other site 693216002501 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 693216002502 ABC-ATPase subunit interface; other site 693216002503 dimer interface [polypeptide binding]; other site 693216002504 putative PBP binding regions; other site 693216002505 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 693216002506 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693216002507 inhibitor-cofactor binding pocket; inhibition site 693216002508 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216002509 catalytic residue [active] 693216002510 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 693216002511 Cl- selectivity filter; other site 693216002512 Cl- binding residues [ion binding]; other site 693216002513 pore gating glutamate residue; other site 693216002514 dimer interface [polypeptide binding]; other site 693216002515 H+/Cl- coupling transport residue; other site 693216002516 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 693216002517 hypothetical protein; Provisional; Region: PRK10578 693216002518 UPF0126 domain; Region: UPF0126; pfam03458 693216002519 UPF0126 domain; Region: UPF0126; pfam03458 693216002520 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 693216002521 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 693216002522 cobalamin binding residues [chemical binding]; other site 693216002523 putative BtuC binding residues; other site 693216002524 dimer interface [polypeptide binding]; other site 693216002525 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 693216002526 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 693216002527 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693216002528 Zn2+ binding site [ion binding]; other site 693216002529 Mg2+ binding site [ion binding]; other site 693216002530 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 693216002531 serine endoprotease; Provisional; Region: PRK10942 693216002532 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 693216002533 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 693216002534 protein binding site [polypeptide binding]; other site 693216002535 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 693216002536 protein binding site [polypeptide binding]; other site 693216002537 hypothetical protein; Provisional; Region: PRK13677 693216002538 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 693216002539 Tetrahydrodipicolinate N-succinyltransferase N-terminal; Region: THDPS_N_2; pfam14805 693216002540 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 693216002541 trimer interface [polypeptide binding]; other site 693216002542 active site 693216002543 substrate binding site [chemical binding]; other site 693216002544 CoA binding site [chemical binding]; other site 693216002545 PII uridylyl-transferase; Provisional; Region: PRK05007 693216002546 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 693216002547 metal binding triad; other site 693216002548 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 693216002549 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693216002550 Zn2+ binding site [ion binding]; other site 693216002551 Mg2+ binding site [ion binding]; other site 693216002552 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 693216002553 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 693216002554 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 693216002555 active site 693216002556 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 693216002557 rRNA interaction site [nucleotide binding]; other site 693216002558 S8 interaction site; other site 693216002559 putative laminin-1 binding site; other site 693216002560 elongation factor Ts; Provisional; Region: tsf; PRK09377 693216002561 UBA/TS-N domain; Region: UBA; pfam00627 693216002562 Elongation factor TS; Region: EF_TS; pfam00889 693216002563 Elongation factor TS; Region: EF_TS; pfam00889 693216002564 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 693216002565 putative nucleotide binding site [chemical binding]; other site 693216002566 uridine monophosphate binding site [chemical binding]; other site 693216002567 homohexameric interface [polypeptide binding]; other site 693216002568 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 693216002569 hinge region; other site 693216002570 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 693216002571 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 693216002572 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 693216002573 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 693216002574 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 693216002575 active site 693216002576 dimer interface [polypeptide binding]; other site 693216002577 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 693216002578 zinc metallopeptidase RseP; Provisional; Region: PRK10779 693216002579 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 693216002580 active site 693216002581 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 693216002582 protein binding site [polypeptide binding]; other site 693216002583 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 693216002584 protein binding site [polypeptide binding]; other site 693216002585 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 693216002586 putative substrate binding region [chemical binding]; other site 693216002587 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 693216002588 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 693216002589 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 693216002590 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 693216002591 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 693216002592 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 693216002593 Surface antigen; Region: Bac_surface_Ag; pfam01103 693216002594 periplasmic chaperone; Provisional; Region: PRK10780 693216002595 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 693216002596 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 693216002597 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 693216002598 trimer interface [polypeptide binding]; other site 693216002599 active site 693216002600 UDP-GlcNAc binding site [chemical binding]; other site 693216002601 lipid binding site [chemical binding]; lipid-binding site 693216002602 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 693216002603 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 693216002604 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 693216002605 active site 693216002606 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 693216002607 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 693216002608 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 693216002609 RNA/DNA hybrid binding site [nucleotide binding]; other site 693216002610 active site 693216002611 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 693216002612 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 693216002613 putative active site [active] 693216002614 putative PHP Thumb interface [polypeptide binding]; other site 693216002615 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 693216002616 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 693216002617 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 693216002618 generic binding surface II; other site 693216002619 generic binding surface I; other site 693216002620 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 693216002621 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 693216002622 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 693216002623 putative sugar binding site [chemical binding]; other site 693216002624 catalytic residues [active] 693216002625 PKD domain; Region: PKD; pfam00801 693216002626 lysine decarboxylase LdcC; Provisional; Region: PRK15399 693216002627 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 693216002628 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 693216002629 homodimer interface [polypeptide binding]; other site 693216002630 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216002631 catalytic residue [active] 693216002632 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 693216002633 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 693216002634 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693216002635 putative metal binding site [ion binding]; other site 693216002636 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 693216002637 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 693216002638 Ligand Binding Site [chemical binding]; other site 693216002639 TilS substrate binding domain; Region: TilS; pfam09179 693216002640 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 693216002641 Cytochrome c553 [Energy production and conversion]; Region: COG2863 693216002642 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 693216002643 Rho-binding antiterminator; Provisional; Region: PRK11625 693216002644 hypothetical protein; Provisional; Region: PRK04964 693216002645 YaeQ protein; Region: YaeQ; pfam07152 693216002646 hypothetical protein; Provisional; Region: PRK09256 693216002647 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 693216002648 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 693216002649 NlpE N-terminal domain; Region: NlpE; cl19736 693216002650 prolyl-tRNA synthetase; Provisional; Region: PRK09194 693216002651 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 693216002652 dimer interface [polypeptide binding]; other site 693216002653 motif 1; other site 693216002654 active site 693216002655 motif 2; other site 693216002656 motif 3; other site 693216002657 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 693216002658 anticodon binding site; other site 693216002659 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 693216002660 homodimer interaction site [polypeptide binding]; other site 693216002661 cofactor binding site; other site 693216002662 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 693216002663 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 693216002664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216002665 dimer interface [polypeptide binding]; other site 693216002666 conserved gate region; other site 693216002667 putative PBP binding loops; other site 693216002668 ABC-ATPase subunit interface; other site 693216002669 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 693216002670 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 693216002671 Walker A/P-loop; other site 693216002672 ATP binding site [chemical binding]; other site 693216002673 Q-loop/lid; other site 693216002674 ABC transporter signature motif; other site 693216002675 Walker B; other site 693216002676 D-loop; other site 693216002677 H-loop/switch region; other site 693216002678 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 693216002679 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 693216002680 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693216002681 active site 693216002682 motif I; other site 693216002683 motif II; other site 693216002684 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 693216002685 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693216002686 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216002687 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 693216002688 putative effector binding pocket; other site 693216002689 dimerization interface [polypeptide binding]; other site 693216002690 hypothetical protein; Provisional; Region: PRK05421 693216002691 putative catalytic site [active] 693216002692 putative metal binding site [ion binding]; other site 693216002693 putative phosphate binding site [ion binding]; other site 693216002694 Methyltransferase domain; Region: Methyltransf_31; pfam13847 693216002695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693216002696 S-adenosylmethionine binding site [chemical binding]; other site 693216002697 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 693216002698 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693216002699 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693216002700 catalytic residue [active] 693216002701 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693216002702 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693216002703 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 693216002704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693216002705 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 693216002706 RNA/DNA hybrid binding site [nucleotide binding]; other site 693216002707 active site 693216002708 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 693216002709 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 693216002710 active site 693216002711 catalytic site [active] 693216002712 substrate binding site [chemical binding]; other site 693216002713 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 693216002714 putative active site [active] 693216002715 catalytic triad [active] 693216002716 dimer interface [polypeptide binding]; other site 693216002717 multimer interface [polypeptide binding]; other site 693216002718 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 693216002719 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 693216002720 active site 693216002721 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 693216002722 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 693216002723 dimer interface [polypeptide binding]; other site 693216002724 active site 693216002725 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 693216002726 putative active site [active] 693216002727 Glutamine amidotransferases class-II; Region: GATase_2; pfam00310 693216002728 putative dimer interface [polypeptide binding]; other site 693216002729 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 693216002730 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 693216002731 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 693216002732 active site 693216002733 catalytic site [active] 693216002734 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 693216002735 active site 693216002736 DNA polymerase IV; Validated; Region: PRK02406 693216002737 DNA binding site [nucleotide binding] 693216002738 hypothetical protein; Reviewed; Region: PRK09588 693216002739 tRNA-splicing ligase RtcB; Region: RtcB; pfam01139 693216002740 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 693216002741 putative peptide chain release factor H; Region: release_prfH; TIGR03072 693216002742 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 693216002743 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 693216002744 metal binding site [ion binding]; metal-binding site 693216002745 dimer interface [polypeptide binding]; other site 693216002746 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693216002747 active site 693216002748 Putative lysophospholipase; Region: Hydrolase_4; cl19140 693216002749 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 693216002750 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 693216002751 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 693216002752 trimer interface [polypeptide binding]; other site 693216002753 eyelet of channel; other site 693216002754 gamma-glutamyl kinase; Provisional; Region: PRK05429 693216002755 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 693216002756 nucleotide binding site [chemical binding]; other site 693216002757 homotetrameric interface [polypeptide binding]; other site 693216002758 putative phosphate binding site [ion binding]; other site 693216002759 putative allosteric binding site; other site 693216002760 PUA domain; Region: PUA; pfam01472 693216002761 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 693216002762 putative catalytic cysteine [active] 693216002763 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 693216002764 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; cl02268 693216002765 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 693216002766 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 693216002767 coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110 693216002768 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 693216002769 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 693216002770 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 693216002771 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693216002772 FeS/SAM binding site; other site 693216002773 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 693216002774 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 693216002775 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 693216002776 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 693216002777 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 693216002778 active site 693216002779 dimer interface [polypeptide binding]; other site 693216002780 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 693216002781 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 693216002782 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 693216002783 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 693216002784 conserved cys residue [active] 693216002785 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693216002786 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 693216002787 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 693216002788 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 693216002789 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 693216002790 homotrimer interaction site [polypeptide binding]; other site 693216002791 putative active site [active] 693216002792 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693216002793 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693216002794 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 693216002795 metal binding triad [ion binding]; metal-binding site 693216002796 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 693216002797 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693216002798 NAD(P) binding site [chemical binding]; other site 693216002799 active site 693216002800 lac repressor; Reviewed; Region: lacI; PRK09526 693216002801 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693216002802 DNA binding site [nucleotide binding] 693216002803 domain linker motif; other site 693216002804 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 693216002805 ligand binding site [chemical binding]; other site 693216002806 dimerization interface (open form) [polypeptide binding]; other site 693216002807 dimerization interface (closed form) [polypeptide binding]; other site 693216002808 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 693216002809 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 693216002810 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 693216002811 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 693216002812 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 693216002813 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 693216002814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216002815 putative substrate translocation pore; other site 693216002816 malate dehydrogenase; Provisional; Region: PRK13529 693216002817 Malic enzyme, N-terminal domain; Region: malic; pfam00390 693216002818 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 693216002819 NAD(P) binding site [chemical binding]; other site 693216002820 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 693216002821 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 693216002822 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 693216002823 tetrameric interface [polypeptide binding]; other site 693216002824 NAD binding site [chemical binding]; other site 693216002825 catalytic residues [active] 693216002826 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 693216002827 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 693216002828 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 693216002829 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 693216002830 putative active site [active] 693216002831 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 693216002832 substrate binding site [chemical binding]; other site 693216002833 ATP binding site [chemical binding]; other site 693216002834 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 693216002835 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 693216002836 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 693216002837 PYR/PP interface [polypeptide binding]; other site 693216002838 dimer interface [polypeptide binding]; other site 693216002839 TPP binding site [chemical binding]; other site 693216002840 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 693216002841 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 693216002842 TPP-binding site; other site 693216002843 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 693216002844 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693216002845 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 693216002846 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 693216002847 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 693216002848 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 693216002849 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 693216002850 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 693216002851 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 693216002852 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216002853 putative substrate translocation pore; other site 693216002854 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 693216002855 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 693216002856 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 693216002857 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 693216002858 Walker A/P-loop; other site 693216002859 ATP binding site [chemical binding]; other site 693216002860 Q-loop/lid; other site 693216002861 ABC transporter signature motif; other site 693216002862 Walker B; other site 693216002863 D-loop; other site 693216002864 H-loop/switch region; other site 693216002865 NIL domain; Region: NIL; pfam09383 693216002866 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 693216002867 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216002868 dimer interface [polypeptide binding]; other site 693216002869 conserved gate region; other site 693216002870 putative PBP binding loops; other site 693216002871 ABC-ATPase subunit interface; other site 693216002872 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 693216002873 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 693216002874 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 693216002875 Phenolic Acid Decarboxylase; Region: PAD; cd14241 693216002876 active site 693216002877 dimer interface [polypeptide binding]; other site 693216002878 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693216002879 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216002880 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693216002881 dimerization interface [polypeptide binding]; other site 693216002882 Protein of unknown function, DUF606; Region: DUF606; pfam04657 693216002883 Protein of unknown function, DUF606; Region: DUF606; pfam04657 693216002884 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693216002885 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216002886 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693216002887 putative effector binding pocket; other site 693216002888 dimerization interface [polypeptide binding]; other site 693216002889 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 693216002890 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 693216002891 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 693216002892 Sulfate transporter family; Region: Sulfate_transp; cl19250 693216002893 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 693216002894 active site clefts [active] 693216002895 zinc binding site [ion binding]; other site 693216002896 dimer interface [polypeptide binding]; other site 693216002897 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 693216002898 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693216002899 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693216002900 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 693216002901 classical (c) SDRs; Region: SDR_c; cd05233 693216002902 NAD(P) binding site [chemical binding]; other site 693216002903 active site 693216002904 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 693216002905 EAL domain; Region: EAL; pfam00563 693216002906 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 693216002907 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 693216002908 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 693216002909 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 693216002910 dimer interface [polypeptide binding]; other site 693216002911 ADP-ribose binding site [chemical binding]; other site 693216002912 active site 693216002913 nudix motif; other site 693216002914 metal binding site [ion binding]; metal-binding site 693216002915 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 693216002916 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 693216002917 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 693216002918 AAA domain; Region: AAA_17; cl19128 693216002919 AAA domain; Region: AAA_33; pfam13671 693216002920 Serine/threonine-protein kinase SNT7; Provisional; Region: PLN03225 693216002921 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 693216002922 putative acyl-acceptor binding pocket; other site 693216002923 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 693216002924 Hok/gef family; Region: HOK_GEF; cl11494 693216002925 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 693216002926 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693216002927 NAD(P) binding site [chemical binding]; other site 693216002928 active site 693216002929 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 693216002930 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693216002931 NAD(P) binding site [chemical binding]; other site 693216002932 active site 693216002933 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 693216002934 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 693216002935 conserved cys residue [active] 693216002936 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693216002937 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 693216002938 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 693216002939 Uncharacterized conserved protein [Function unknown]; Region: COG2427 693216002940 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 693216002941 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 693216002942 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 693216002943 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 693216002944 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 693216002945 [4Fe-4S] binding site [ion binding]; other site 693216002946 molybdopterin cofactor binding site; other site 693216002947 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 693216002948 molybdopterin cofactor binding site; other site 693216002949 S-methylmethionine transporter; Provisional; Region: PRK11387 693216002950 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 693216002951 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 693216002952 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 693216002953 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693216002954 substrate binding pocket [chemical binding]; other site 693216002955 membrane-bound complex binding site; other site 693216002956 hinge residues; other site 693216002957 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 693216002958 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 693216002959 Walker A/P-loop; other site 693216002960 ATP binding site [chemical binding]; other site 693216002961 Q-loop/lid; other site 693216002962 ABC transporter signature motif; other site 693216002963 Walker B; other site 693216002964 D-loop; other site 693216002965 H-loop/switch region; other site 693216002966 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 693216002967 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216002968 dimer interface [polypeptide binding]; other site 693216002969 conserved gate region; other site 693216002970 putative PBP binding loops; other site 693216002971 ABC-ATPase subunit interface; other site 693216002972 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 693216002973 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 693216002974 active site 693216002975 iron coordination sites [ion binding]; other site 693216002976 substrate binding pocket [chemical binding]; other site 693216002977 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 693216002978 putative acyl-acceptor binding pocket; other site 693216002979 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 693216002980 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 693216002981 dimer interface [polypeptide binding]; other site 693216002982 active site 693216002983 Schiff base residues; other site 693216002984 Competence-damaged protein; Region: CinA; pfam02464 693216002985 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 693216002986 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 693216002987 Autotransporter beta-domain; Region: Autotransporter; smart00869 693216002988 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 693216002989 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 693216002990 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 693216002991 catalytic triad [active] 693216002992 conserved cis-peptide bond; other site 693216002993 microcin B17 transporter; Reviewed; Region: PRK11098 693216002994 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 693216002995 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 693216002996 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 693216002997 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 693216002998 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 693216002999 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 693216003000 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 693216003001 drug efflux system protein MdtG; Provisional; Region: PRK09874 693216003002 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216003003 putative substrate translocation pore; other site 693216003004 anti-RssB factor; Provisional; Region: PRK10244 693216003005 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 693216003006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216003007 putative substrate translocation pore; other site 693216003008 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 693216003009 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 693216003010 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 693216003011 Predicted membrane protein [Function unknown]; Region: COG2323 693216003012 hypothetical protein; Validated; Region: PRK00124 693216003013 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3416 693216003014 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 693216003015 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 693216003016 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 693216003017 ADP binding site [chemical binding]; other site 693216003018 magnesium binding site [ion binding]; other site 693216003019 putative shikimate binding site; other site 693216003020 hypothetical protein; Provisional; Region: PRK10380 693216003021 hypothetical protein; Provisional; Region: PRK10481 693216003022 hypothetical protein; Provisional; Region: PRK10579 693216003023 recombination associated protein; Reviewed; Region: rdgC; PRK00321 693216003024 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 693216003025 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 693216003026 nucleotide binding site [chemical binding]; other site 693216003027 exonuclease subunit SbcC; Provisional; Region: PRK10246 693216003028 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693216003029 Walker A/P-loop; other site 693216003030 ATP binding site [chemical binding]; other site 693216003031 Q-loop/lid; other site 693216003032 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693216003033 ABC transporter signature motif; other site 693216003034 Walker B; other site 693216003035 D-loop; other site 693216003036 H-loop/switch region; other site 693216003037 exonuclease subunit SbcD; Provisional; Region: PRK10966 693216003038 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 693216003039 active site 693216003040 metal binding site [ion binding]; metal-binding site 693216003041 DNA binding site [nucleotide binding] 693216003042 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 693216003043 transcriptional regulator PhoB; Provisional; Region: PRK10161 693216003044 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693216003045 active site 693216003046 phosphorylation site [posttranslational modification] 693216003047 intermolecular recognition site; other site 693216003048 dimerization interface [polypeptide binding]; other site 693216003049 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693216003050 DNA binding site [nucleotide binding] 693216003051 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 693216003052 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 693216003053 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693216003054 putative active site [active] 693216003055 heme pocket [chemical binding]; other site 693216003056 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693216003057 dimer interface [polypeptide binding]; other site 693216003058 phosphorylation site [posttranslational modification] 693216003059 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693216003060 ATP binding site [chemical binding]; other site 693216003061 Mg2+ binding site [ion binding]; other site 693216003062 G-X-G motif; other site 693216003063 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 693216003064 putative proline-specific permease; Provisional; Region: proY; PRK10580 693216003065 Spore germination protein; Region: Spore_permease; cl17796 693216003066 maltodextrin glucosidase; Provisional; Region: PRK10785 693216003067 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 693216003068 homodimer interface [polypeptide binding]; other site 693216003069 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 693216003070 active site 693216003071 homodimer interface [polypeptide binding]; other site 693216003072 catalytic site [active] 693216003073 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 693216003074 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 693216003075 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 693216003076 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 693216003077 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 693216003078 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 693216003079 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 693216003080 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 693216003081 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 693216003082 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 693216003083 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 693216003084 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 693216003085 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 693216003086 Protein export membrane protein; Region: SecD_SecF; pfam02355 693216003087 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 693216003088 hypothetical protein; Provisional; Region: PRK11530 693216003089 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 693216003090 ATP cone domain; Region: ATP-cone; pfam03477 693216003091 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 693216003092 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 693216003093 catalytic motif [active] 693216003094 Zn binding site [ion binding]; other site 693216003095 RibD C-terminal domain; Region: RibD_C; cl17279 693216003096 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 693216003097 homopentamer interface [polypeptide binding]; other site 693216003098 active site 693216003099 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 693216003100 thiamine monophosphate kinase; Provisional; Region: PRK05731 693216003101 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 693216003102 ATP binding site [chemical binding]; other site 693216003103 dimerization interface [polypeptide binding]; other site 693216003104 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693216003105 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 693216003106 active site 693216003107 catalytic tetrad [active] 693216003108 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 693216003109 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 693216003110 TPP-binding site; other site 693216003111 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 693216003112 PYR/PP interface [polypeptide binding]; other site 693216003113 dimer interface [polypeptide binding]; other site 693216003114 TPP binding site [chemical binding]; other site 693216003115 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 693216003116 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 693216003117 substrate binding pocket [chemical binding]; other site 693216003118 chain length determination region; other site 693216003119 active site lid residues [active] 693216003120 substrate-Mg2+ binding site; other site 693216003121 catalytic residues [active] 693216003122 aspartate-rich region 1; other site 693216003123 aspartate-rich region 2; other site 693216003124 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 693216003125 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 693216003126 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 693216003127 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 693216003128 Ligand Binding Site [chemical binding]; other site 693216003129 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 693216003130 active site residue [active] 693216003131 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 693216003132 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 693216003133 conserved cys residue [active] 693216003134 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 693216003135 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 693216003136 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 693216003137 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 693216003138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216003139 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693216003140 putative substrate translocation pore; other site 693216003141 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 693216003142 putative active site [active] 693216003143 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 693216003144 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 693216003145 Subunit I/III interface [polypeptide binding]; other site 693216003146 Subunit III/IV interface [polypeptide binding]; other site 693216003147 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 693216003148 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 693216003149 D-pathway; other site 693216003150 Putative ubiquinol binding site [chemical binding]; other site 693216003151 Low-spin heme (heme b) binding site [chemical binding]; other site 693216003152 Putative water exit pathway; other site 693216003153 Binuclear center (heme o3/CuB) [ion binding]; other site 693216003154 K-pathway; other site 693216003155 Putative proton exit pathway; other site 693216003156 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 693216003157 The cupredoxin domain of Ubiquinol oxidase subunit II; Region: CuRO_UO_II; cd04212 693216003158 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 693216003159 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 693216003160 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 693216003161 nucleotide binding site [chemical binding]; other site 693216003162 putative NEF/HSP70 interaction site [polypeptide binding]; other site 693216003163 SBD interface [polypeptide binding]; other site 693216003164 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 693216003165 HSP70 interaction site [polypeptide binding]; other site 693216003166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216003167 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693216003168 putative substrate translocation pore; other site 693216003169 hypothetical protein; Provisional; Region: PRK11627 693216003170 transcriptional regulator BolA; Provisional; Region: PRK11628 693216003171 trigger factor; Provisional; Region: tig; PRK01490 693216003172 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 693216003173 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 693216003174 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 693216003175 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 693216003176 oligomer interface [polypeptide binding]; other site 693216003177 active site residues [active] 693216003178 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 693216003179 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 693216003180 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693216003181 Walker A motif; other site 693216003182 ATP binding site [chemical binding]; other site 693216003183 Walker B motif; other site 693216003184 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 693216003185 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 693216003186 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 693216003187 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693216003188 Walker A motif; other site 693216003189 ATP binding site [chemical binding]; other site 693216003190 Walker B motif; other site 693216003191 arginine finger; other site 693216003192 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 693216003193 histone-like DNA-binding protein HU; Region: HU; cd13831 693216003194 dimer interface [polypeptide binding]; other site 693216003195 DNA binding site [nucleotide binding] 693216003196 periplasmic folding chaperone; Provisional; Region: PRK10788 693216003197 SurA N-terminal domain; Region: SurA_N_3; cl07813 693216003198 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 693216003199 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 693216003200 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 693216003201 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 693216003202 active site 693216003203 CrcB-like protein; Region: CRCB; cl09114 693216003204 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 693216003205 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 693216003206 Ligand Binding Site [chemical binding]; other site 693216003207 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 693216003208 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 693216003209 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 693216003210 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 693216003211 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693216003212 active site 693216003213 motif I; other site 693216003214 motif II; other site 693216003215 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 693216003216 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 693216003217 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 693216003218 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 693216003219 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 693216003220 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 693216003221 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 693216003222 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 693216003223 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693216003224 catalytic residue [active] 693216003225 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 693216003226 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693216003227 putative DNA binding site [nucleotide binding]; other site 693216003228 dimerization interface [polypeptide binding]; other site 693216003229 putative Zn2+ binding site [ion binding]; other site 693216003230 AsnC family; Region: AsnC_trans_reg; pfam01037 693216003231 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693216003232 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 693216003233 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693216003234 Walker A/P-loop; other site 693216003235 ATP binding site [chemical binding]; other site 693216003236 Q-loop/lid; other site 693216003237 ABC transporter signature motif; other site 693216003238 Walker B; other site 693216003239 D-loop; other site 693216003240 H-loop/switch region; other site 693216003241 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 693216003242 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693216003243 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693216003244 Walker A/P-loop; other site 693216003245 ATP binding site [chemical binding]; other site 693216003246 Q-loop/lid; other site 693216003247 ABC transporter signature motif; other site 693216003248 Walker B; other site 693216003249 D-loop; other site 693216003250 H-loop/switch region; other site 693216003251 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 693216003252 Nitrogen regulatory protein P-II; Region: P-II; smart00938 693216003253 ammonium transporter; Provisional; Region: PRK10666 693216003254 acyl-CoA thioesterase II; Provisional; Region: PRK10526 693216003255 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 693216003256 active site 693216003257 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 693216003258 catalytic triad [active] 693216003259 dimer interface [polypeptide binding]; other site 693216003260 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 693216003261 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 693216003262 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 693216003263 DNA binding site [nucleotide binding] 693216003264 active site 693216003265 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 693216003266 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 693216003267 CRISPR/Cas system-associated protein Cas3; Region: Cas3_I; cd09639 693216003268 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 693216003269 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 693216003270 CT1975-like protein; Region: Cas_CT1975; pfam09344 693216003271 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 693216003272 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 693216003273 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 693216003274 putative ssRNA endonuclease; Provisional; Region: PRK11558 693216003275 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 693216003276 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693216003277 DNA-binding site [nucleotide binding]; DNA binding site 693216003278 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693216003279 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216003280 homodimer interface [polypeptide binding]; other site 693216003281 catalytic residue [active] 693216003282 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 693216003283 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 693216003284 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693216003285 Coenzyme A binding pocket [chemical binding]; other site 693216003286 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 693216003287 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 693216003288 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 693216003289 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693216003290 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216003291 dimer interface [polypeptide binding]; other site 693216003292 conserved gate region; other site 693216003293 putative PBP binding loops; other site 693216003294 ABC-ATPase subunit interface; other site 693216003295 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 693216003296 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 693216003297 Walker A/P-loop; other site 693216003298 ATP binding site [chemical binding]; other site 693216003299 Q-loop/lid; other site 693216003300 ABC transporter signature motif; other site 693216003301 Walker B; other site 693216003302 D-loop; other site 693216003303 H-loop/switch region; other site 693216003304 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 693216003305 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 693216003306 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 693216003307 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 693216003308 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 693216003309 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693216003310 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693216003311 dimer interface [polypeptide binding]; other site 693216003312 putative CheW interface [polypeptide binding]; other site 693216003313 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 693216003314 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 693216003315 maltose O-acetyltransferase; Provisional; Region: PRK10092 693216003316 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 693216003317 active site 693216003318 substrate binding site [chemical binding]; other site 693216003319 trimer interface [polypeptide binding]; other site 693216003320 CoA binding site [chemical binding]; other site 693216003321 gene expression modulator; Provisional; Region: PRK10945 693216003322 Hha toxicity attenuator; Provisional; Region: PRK10667 693216003323 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 693216003324 MMPL family; Region: MMPL; cl14618 693216003325 MMPL family; Region: MMPL; cl14618 693216003326 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 693216003327 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693216003328 HlyD family secretion protein; Region: HlyD_3; pfam13437 693216003329 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 693216003330 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693216003331 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 693216003332 hypothetical protein; Provisional; Region: PRK11281 693216003333 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 693216003334 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 693216003335 Mechanosensitive ion channel; Region: MS_channel; pfam00924 693216003336 hypothetical protein; Provisional; Region: PRK11038 693216003337 Primosomal replication protein priB and priC; Region: priB_priC; cl11483 693216003338 hypothetical protein; Provisional; Region: PRK10527 693216003339 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693216003340 active site 693216003341 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 693216003342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693216003343 Walker A motif; other site 693216003344 ATP binding site [chemical binding]; other site 693216003345 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 693216003346 Walker B motif; other site 693216003347 arginine finger; other site 693216003348 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 693216003349 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 693216003350 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 693216003351 hypothetical protein; Validated; Region: PRK00153 693216003352 recombination protein RecR; Reviewed; Region: recR; PRK00076 693216003353 RecR protein; Region: RecR; pfam02132 693216003354 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 693216003355 putative active site [active] 693216003356 putative metal-binding site [ion binding]; other site 693216003357 tetramer interface [polypeptide binding]; other site 693216003358 heat shock protein 90; Provisional; Region: PRK05218 693216003359 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693216003360 ATP binding site [chemical binding]; other site 693216003361 Mg2+ binding site [ion binding]; other site 693216003362 G-X-G motif; other site 693216003363 Hsp90 protein; Region: HSP90; pfam00183 693216003364 adenylate kinase; Reviewed; Region: adk; PRK00279 693216003365 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 693216003366 AMP-binding site [chemical binding]; other site 693216003367 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 693216003368 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 693216003369 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 693216003370 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 693216003371 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 693216003372 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 693216003373 transmembrane helices; other site 693216003374 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 693216003375 ferrochelatase; Reviewed; Region: hemH; PRK00035 693216003376 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 693216003377 C-terminal domain interface [polypeptide binding]; other site 693216003378 active site 693216003379 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 693216003380 active site 693216003381 N-terminal domain interface [polypeptide binding]; other site 693216003382 inosine/guanosine kinase; Provisional; Region: PRK15074 693216003383 substrate binding site [chemical binding]; other site 693216003384 ATP binding site [chemical binding]; other site 693216003385 putative cation:proton antiport protein; Provisional; Region: PRK10669 693216003386 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 693216003387 TrkA-N domain; Region: TrkA_N; pfam02254 693216003388 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 693216003389 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 693216003390 active site 693216003391 metal binding site [ion binding]; metal-binding site 693216003392 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 693216003393 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 693216003394 putative deacylase active site [active] 693216003395 TraB family; Region: TraB; cl12050 693216003396 copper exporting ATPase; Provisional; Region: copA; PRK10671 693216003397 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 693216003398 metal-binding site [ion binding] 693216003399 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 693216003400 metal-binding site [ion binding] 693216003401 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 693216003402 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693216003403 motif II; other site 693216003404 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 693216003405 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 693216003406 DNA binding residues [nucleotide binding] 693216003407 dimer interface [polypeptide binding]; other site 693216003408 copper binding site [ion binding]; other site 693216003409 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 693216003410 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 693216003411 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 693216003412 Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829 693216003413 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 693216003414 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 693216003415 Tetratricopeptide repeat; Region: TPR_20; pfam14561 693216003416 short chain dehydrogenase; Validated; Region: PRK06182 693216003417 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 693216003418 NADP binding site [chemical binding]; other site 693216003419 active site 693216003420 steroid binding site; other site 693216003421 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 693216003422 active site 693216003423 catalytic triad [active] 693216003424 oxyanion hole [active] 693216003425 switch loop; other site 693216003426 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 693216003427 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 693216003428 Walker A/P-loop; other site 693216003429 ATP binding site [chemical binding]; other site 693216003430 Q-loop/lid; other site 693216003431 ABC transporter signature motif; other site 693216003432 Walker B; other site 693216003433 D-loop; other site 693216003434 H-loop/switch region; other site 693216003435 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 693216003436 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 693216003437 FtsX-like permease family; Region: FtsX; pfam02687 693216003438 FtsX-like permease family; Region: FtsX; pfam02687 693216003439 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 693216003440 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 693216003441 active site residue [active] 693216003442 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 693216003443 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 693216003444 dimer interface [polypeptide binding]; other site 693216003445 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216003446 catalytic residue [active] 693216003447 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 693216003448 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 693216003449 homodimer interface [polypeptide binding]; other site 693216003450 substrate-cofactor binding pocket; other site 693216003451 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216003452 catalytic residue [active] 693216003453 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 693216003454 ATP-grasp domain; Region: ATP-grasp; pfam02222 693216003455 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 693216003456 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 693216003457 putative active site [active] 693216003458 putative metal binding site [ion binding]; other site 693216003459 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 693216003460 substrate binding site [chemical binding]; other site 693216003461 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 693216003462 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 693216003463 active site 693216003464 HIGH motif; other site 693216003465 KMSKS motif; other site 693216003466 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 693216003467 tRNA binding surface [nucleotide binding]; other site 693216003468 anticodon binding site; other site 693216003469 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 693216003470 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693216003471 DNA binding site [nucleotide binding] 693216003472 domain linker motif; other site 693216003473 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 693216003474 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 693216003475 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 693216003476 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 693216003477 active site turn [active] 693216003478 phosphorylation site [posttranslational modification] 693216003479 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693216003480 RNA binding surface [nucleotide binding]; other site 693216003481 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 693216003482 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 693216003483 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 693216003484 homodimer interface [polypeptide binding]; other site 693216003485 NADP binding site [chemical binding]; other site 693216003486 substrate binding site [chemical binding]; other site 693216003487 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 693216003488 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 693216003489 Int/Topo IB signature motif; other site 693216003490 Nineteen complex-related protein 2; Region: NTR2; pfam15458 693216003491 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 693216003492 Protein of unknown function (DUF2737); Region: DUF2737; pfam10930 693216003493 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 693216003494 RecT family; Region: RecT; pfam03837 693216003495 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 693216003496 cIII protein family; Region: cIII; pfam08134 693216003497 Protein of unknown function (DUF551); Region: DUF551; pfam04448 693216003498 putative NHN endonuclease; Region: PHA00280 693216003499 HNH endonuclease; Region: HNH_3; pfam13392 693216003500 AP2 domain; Region: AP2; pfam00847 693216003501 DNA binding site [nucleotide binding] 693216003502 Predicted transcriptional regulator [Transcription]; Region: COG2932 693216003503 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 693216003504 Catalytic site [active] 693216003505 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693216003506 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693216003507 non-specific DNA binding site [nucleotide binding]; other site 693216003508 salt bridge; other site 693216003509 sequence-specific DNA binding site [nucleotide binding]; other site 693216003510 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693216003511 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693216003512 non-specific DNA binding site [nucleotide binding]; other site 693216003513 salt bridge; other site 693216003514 sequence-specific DNA binding site [nucleotide binding]; other site 693216003515 Bacteriophage CII protein; Region: Phage_CII; pfam05269 693216003516 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 693216003517 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 693216003518 replicative DNA helicase; Region: DnaB; TIGR00665 693216003519 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 693216003520 Walker A motif; other site 693216003521 ATP binding site [chemical binding]; other site 693216003522 Walker B motif; other site 693216003523 NinB protein; Region: NinB; pfam05772 693216003524 NinF protein; Region: NinF; pfam05810 693216003525 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 693216003526 endodeoxyribonuclease RUS; Reviewed; Region: PRK09786 693216003527 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 693216003528 active site 693216003529 Phage NinH protein; Region: Phage_NinH; pfam06322 693216003530 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693216003531 Antitermination protein; Region: Antiterm; pfam03589 693216003532 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cl19048 693216003533 Antitermination protein; Region: Antiterm; pfam03589 693216003534 Inositol phospholipid synthesis and fat-storage-inducing TM; Region: Scs3p; pfam10261 693216003535 Predicted chitinase [General function prediction only]; Region: COG3179 693216003536 Protein of unknown function (DUF2570); Region: DUF2570; pfam10828 693216003537 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 693216003538 Phage terminase large subunit; Region: Terminase_3; cl12054 693216003539 Phage portal protein; Region: Phage_portal; cl19194 693216003540 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 693216003541 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693216003542 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; cl19842 693216003543 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 693216003544 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 693216003545 active site 693216003546 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 693216003547 NlpC/P60 family; Region: NLPC_P60; cl17555 693216003548 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 693216003549 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 693216003550 active site 693216003551 catalytic triad [active] 693216003552 oxyanion hole [active] 693216003553 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 693216003554 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 693216003555 catalytic residues [active] 693216003556 dimer interface [polypeptide binding]; other site 693216003557 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 693216003558 classical (c) SDRs; Region: SDR_c; cd05233 693216003559 NAD(P) binding site [chemical binding]; other site 693216003560 active site 693216003561 Predicted transcriptional regulators [Transcription]; Region: COG1733 693216003562 dimerization interface [polypeptide binding]; other site 693216003563 putative DNA binding site [nucleotide binding]; other site 693216003564 putative Zn2+ binding site [ion binding]; other site 693216003565 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 693216003566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216003567 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693216003568 putative substrate translocation pore; other site 693216003569 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693216003570 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693216003571 dimerization interface [polypeptide binding]; other site 693216003572 putative DNA binding site [nucleotide binding]; other site 693216003573 putative Zn2+ binding site [ion binding]; other site 693216003574 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 693216003575 active site residue [active] 693216003576 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 693216003577 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 693216003578 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 693216003579 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693216003580 ligand binding site [chemical binding]; other site 693216003581 Glycosyltransferase (GlcNAc); Region: GlcNAc; pfam11397 693216003582 putative major fimbrial protein SthE; Provisional; Region: PRK15292 693216003583 Fimbrial protein; Region: Fimbrial; pfam00419 693216003584 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 693216003585 ImpA-related N-terminal; Region: ImpA-rel_N; cl19907 693216003586 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 693216003587 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 693216003588 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 693216003589 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693216003590 Walker A motif; other site 693216003591 ATP binding site [chemical binding]; other site 693216003592 Walker B motif; other site 693216003593 arginine finger; other site 693216003594 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693216003595 Walker A motif; other site 693216003596 ATP binding site [chemical binding]; other site 693216003597 Walker B motif; other site 693216003598 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 693216003599 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 693216003600 putative chaperone protein EcpD; Provisional; Region: PRK09926 693216003601 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 693216003602 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 693216003603 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 693216003604 PapC N-terminal domain; Region: PapC_N; pfam13954 693216003605 Outer membrane usher protein; Region: Usher; pfam00577 693216003606 PapC C-terminal domain; Region: PapC_C; pfam13953 693216003607 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 693216003608 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 693216003609 Protein of unknown function (DUF796); Region: DUF796; pfam05638 693216003610 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 693216003611 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 693216003612 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 693216003613 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693216003614 ligand binding site [chemical binding]; other site 693216003615 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 693216003616 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 693216003617 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 693216003618 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 693216003619 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 693216003620 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 693216003621 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 693216003622 PAAR motif; Region: PAAR_motif; pfam05488 693216003623 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 693216003624 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 693216003625 ImpE protein; Region: ImpE; pfam07024 693216003626 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 693216003627 Nitrate and nitrite sensing; Region: NIT; pfam08376 693216003628 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693216003629 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693216003630 dimerization interface [polypeptide binding]; other site 693216003631 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693216003632 dimer interface [polypeptide binding]; other site 693216003633 putative CheW interface [polypeptide binding]; other site 693216003634 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 693216003635 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 693216003636 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693216003637 Coenzyme A binding pocket [chemical binding]; other site 693216003638 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 693216003639 N-formylglutamate amidohydrolase; Region: FGase; cl01522 693216003640 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 693216003641 outer membrane receptor FepA; Provisional; Region: PRK13524 693216003642 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693216003643 N-terminal plug; other site 693216003644 ligand-binding site [chemical binding]; other site 693216003645 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 693216003646 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 693216003647 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 693216003648 MbtH-like protein; Region: MbtH; cl01279 693216003649 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 693216003650 Condensation domain; Region: Condensation; cl19241 693216003651 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 693216003652 acyl-activating enzyme (AAE) consensus motif; other site 693216003653 AMP binding site [chemical binding]; other site 693216003654 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 693216003655 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 693216003656 Cupin domain; Region: Cupin_2; cl17218 693216003657 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 693216003658 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 693216003659 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 693216003660 intersubunit interface [polypeptide binding]; other site 693216003661 active site 693216003662 Zn2+ binding site [ion binding]; other site 693216003663 methionine aminotransferase; Validated; Region: PRK09082 693216003664 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693216003665 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216003666 homodimer interface [polypeptide binding]; other site 693216003667 catalytic residue [active] 693216003668 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 693216003669 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216003670 LysR substrate binding domain; Region: LysR_substrate; pfam03466 693216003671 dimerization interface [polypeptide binding]; other site 693216003672 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 693216003673 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 693216003674 dimer interface [polypeptide binding]; other site 693216003675 decamer (pentamer of dimers) interface [polypeptide binding]; other site 693216003676 catalytic triad [active] 693216003677 peroxidatic and resolving cysteines [active] 693216003678 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 693216003679 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 693216003680 catalytic residue [active] 693216003681 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 693216003682 catalytic residues [active] 693216003683 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 693216003684 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693216003685 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 693216003686 Ligand Binding Site [chemical binding]; other site 693216003687 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 693216003688 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 693216003689 NAD binding site [chemical binding]; other site 693216003690 catalytic Zn binding site [ion binding]; other site 693216003691 structural Zn binding site [ion binding]; other site 693216003692 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 693216003693 Rnk N-terminus; Region: Rnk_N; pfam14760 693216003694 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 693216003695 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 693216003696 fructuronate transporter; Provisional; Region: PRK10034; cl15264 693216003697 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 693216003698 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 693216003699 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216003700 dimer interface [polypeptide binding]; other site 693216003701 conserved gate region; other site 693216003702 putative PBP binding loops; other site 693216003703 ABC-ATPase subunit interface; other site 693216003704 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 693216003705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216003706 dimer interface [polypeptide binding]; other site 693216003707 conserved gate region; other site 693216003708 putative PBP binding loops; other site 693216003709 ABC-ATPase subunit interface; other site 693216003710 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 693216003711 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 693216003712 Walker A/P-loop; other site 693216003713 ATP binding site [chemical binding]; other site 693216003714 Q-loop/lid; other site 693216003715 ABC transporter signature motif; other site 693216003716 Walker B; other site 693216003717 D-loop; other site 693216003718 H-loop/switch region; other site 693216003719 TOBE domain; Region: TOBE_2; pfam08402 693216003720 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 693216003721 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 693216003722 Ca binding site [ion binding]; other site 693216003723 active site 693216003724 catalytic site [active] 693216003725 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 693216003726 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 693216003727 Ca binding site [ion binding]; other site 693216003728 active site 693216003729 catalytic site [active] 693216003730 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 693216003731 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 693216003732 B1 nucleotide binding pocket [chemical binding]; other site 693216003733 B2 nucleotide binding pocket [chemical binding]; other site 693216003734 CAS motifs; other site 693216003735 active site 693216003736 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 693216003737 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 693216003738 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 693216003739 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 693216003740 DNA-binding site [nucleotide binding]; DNA binding site 693216003741 RNA-binding motif; other site 693216003742 chromosome condensation membrane protein; Provisional; Region: PRK14196 693216003743 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 693216003744 putative active site [active] 693216003745 catalytic triad [active] 693216003746 putative dimer interface [polypeptide binding]; other site 693216003747 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 693216003748 lipoyl synthase; Provisional; Region: PRK05481 693216003749 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693216003750 FeS/SAM binding site; other site 693216003751 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 693216003752 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216003753 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693216003754 dimerization interface [polypeptide binding]; other site 693216003755 lipoate-protein ligase B; Provisional; Region: PRK14342 693216003756 hypothetical protein; Provisional; Region: PRK04998 693216003757 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 693216003758 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 693216003759 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 693216003760 rare lipoprotein A; Provisional; Region: PRK10672 693216003761 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 693216003762 Sporulation related domain; Region: SPOR; pfam05036 693216003763 cell wall shape-determining protein; Provisional; Region: PRK10794 693216003764 penicillin-binding protein 2; Provisional; Region: PRK10795 693216003765 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 693216003766 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 693216003767 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 693216003768 ribosome-associated protein; Provisional; Region: PRK11538 693216003769 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 693216003770 catalytic core [active] 693216003771 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 693216003772 active site 693216003773 (T/H)XGH motif; other site 693216003774 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 693216003775 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 693216003776 Processivity clamp loader gamma complex DNA pol III C-term; Region: DNA_pol3_delt_C; pfam14840 693216003777 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 693216003778 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 693216003779 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 693216003780 active site 693216003781 HIGH motif; other site 693216003782 KMSKS motif; other site 693216003783 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 693216003784 tRNA binding surface [nucleotide binding]; other site 693216003785 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 693216003786 hypothetical protein; Provisional; Region: PRK11032 693216003787 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 693216003788 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 693216003789 Walker A/P-loop; other site 693216003790 ATP binding site [chemical binding]; other site 693216003791 Q-loop/lid; other site 693216003792 ABC transporter signature motif; other site 693216003793 Walker B; other site 693216003794 D-loop; other site 693216003795 H-loop/switch region; other site 693216003796 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 693216003797 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216003798 dimer interface [polypeptide binding]; other site 693216003799 conserved gate region; other site 693216003800 putative PBP binding loops; other site 693216003801 ABC-ATPase subunit interface; other site 693216003802 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 693216003803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216003804 dimer interface [polypeptide binding]; other site 693216003805 conserved gate region; other site 693216003806 putative PBP binding loops; other site 693216003807 ABC-ATPase subunit interface; other site 693216003808 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 693216003809 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693216003810 substrate binding pocket [chemical binding]; other site 693216003811 membrane-bound complex binding site; other site 693216003812 hinge residues; other site 693216003813 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 693216003814 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 693216003815 putative active site [active] 693216003816 catalytic triad [active] 693216003817 putative dimer interface [polypeptide binding]; other site 693216003818 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 693216003819 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 693216003820 Transporter associated domain; Region: CorC_HlyC; smart01091 693216003821 metal-binding heat shock protein; Provisional; Region: PRK00016 693216003822 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 693216003823 PhoH-like protein; Region: PhoH; pfam02562 693216003824 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 693216003825 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 693216003826 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693216003827 FeS/SAM binding site; other site 693216003828 TRAM domain; Region: TRAM; pfam01938 693216003829 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 693216003830 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 693216003831 asparagine synthetase B; Provisional; Region: asnB; PRK09431 693216003832 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 693216003833 active site 693216003834 dimer interface [polypeptide binding]; other site 693216003835 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 693216003836 Ligand Binding Site [chemical binding]; other site 693216003837 Molecular Tunnel; other site 693216003838 UMP phosphatase; Provisional; Region: PRK10444 693216003839 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693216003840 active site 693216003841 motif I; other site 693216003842 motif II; other site 693216003843 MarR family; Region: MarR_2; cl17246 693216003844 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 693216003845 ROK family; Region: ROK; pfam00480 693216003846 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 693216003847 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 693216003848 active site 693216003849 dimer interface [polypeptide binding]; other site 693216003850 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 693216003851 active site 693216003852 trimer interface [polypeptide binding]; other site 693216003853 allosteric site; other site 693216003854 active site lid [active] 693216003855 hexamer (dimer of trimers) interface [polypeptide binding]; other site 693216003856 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 693216003857 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 693216003858 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 693216003859 active site turn [active] 693216003860 phosphorylation site [posttranslational modification] 693216003861 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 693216003862 HPr interaction site; other site 693216003863 glycerol kinase (GK) interaction site [polypeptide binding]; other site 693216003864 active site 693216003865 phosphorylation site [posttranslational modification] 693216003866 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 693216003867 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 693216003868 active site 693216003869 HIGH motif; other site 693216003870 KMSKS motif; other site 693216003871 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 693216003872 outer membrane porin, OprD family; Region: OprD; pfam03573 693216003873 Putative carbohydrate binding domain; Region: CHB_HEX; smart01081 693216003874 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 693216003875 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 693216003876 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a...; Region: GH20_Sm-chitobiase-like; cd06569 693216003877 active site 693216003878 C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847 693216003879 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 693216003880 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 693216003881 metal binding site 2 [ion binding]; metal-binding site 693216003882 putative DNA binding helix; other site 693216003883 metal binding site 1 [ion binding]; metal-binding site 693216003884 dimer interface [polypeptide binding]; other site 693216003885 structural Zn2+ binding site [ion binding]; other site 693216003886 flavodoxin FldA; Validated; Region: PRK09267 693216003887 LexA regulated protein; Provisional; Region: PRK11675 693216003888 acyl-CoA esterase; Provisional; Region: PRK10673 693216003889 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 693216003890 replication initiation regulator SeqA; Provisional; Region: PRK11187 693216003891 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 693216003892 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 693216003893 active site 693216003894 substrate binding site [chemical binding]; other site 693216003895 metal binding site [ion binding]; metal-binding site 693216003896 putrescine transporter; Provisional; Region: potE; PRK10655 693216003897 ornithine decarboxylase; Provisional; Region: PRK13578 693216003898 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 693216003899 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 693216003900 homodimer interface [polypeptide binding]; other site 693216003901 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216003902 catalytic residue [active] 693216003903 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 693216003904 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 693216003905 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693216003906 active site 693216003907 phosphorylation site [posttranslational modification] 693216003908 intermolecular recognition site; other site 693216003909 dimerization interface [polypeptide binding]; other site 693216003910 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693216003911 DNA binding site [nucleotide binding] 693216003912 sensor protein KdpD; Provisional; Region: PRK10490 693216003913 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 693216003914 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 693216003915 Ligand Binding Site [chemical binding]; other site 693216003916 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 693216003917 GAF domain; Region: GAF_3; pfam13492 693216003918 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693216003919 dimer interface [polypeptide binding]; other site 693216003920 phosphorylation site [posttranslational modification] 693216003921 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693216003922 ATP binding site [chemical binding]; other site 693216003923 Mg2+ binding site [ion binding]; other site 693216003924 G-X-G motif; other site 693216003925 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 693216003926 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 693216003927 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 693216003928 Soluble P-type ATPase [General function prediction only]; Region: COG4087 693216003929 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 693216003930 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 693216003931 Protein of unknown function (DUF523); Region: DUF523; pfam04463 693216003932 Uncharacterized conserved protein [Function unknown]; Region: COG3272 693216003933 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 693216003934 DNA photolyase; Region: DNA_photolyase; pfam00875 693216003935 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 693216003936 metal-binding protein; Provisional; Region: PRK10799 693216003937 Allophanate hydrolase subunit 1; Region: AHS1; cl19310 693216003938 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 693216003939 LamB/YcsF family protein; Provisional; Region: PRK05406 693216003940 MarR family; Region: MarR_2; cl17246 693216003941 Protein of unknown function (DUF969); Region: DUF969; pfam06149 693216003942 Protein of unknown function (DUF979); Region: DUF979; pfam06166 693216003943 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 693216003944 endonuclease VIII; Provisional; Region: PRK10445 693216003945 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 693216003946 DNA binding site [nucleotide binding] 693216003947 catalytic residue [active] 693216003948 putative catalytic residues [active] 693216003949 H2TH interface [polypeptide binding]; other site 693216003950 intercalation triad [nucleotide binding]; other site 693216003951 substrate specificity determining residue; other site 693216003952 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 693216003953 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 693216003954 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 693216003955 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 693216003956 dimer interface [polypeptide binding]; other site 693216003957 active site 693216003958 citrylCoA binding site [chemical binding]; other site 693216003959 NADH binding [chemical binding]; other site 693216003960 cationic pore residues; other site 693216003961 oxalacetate/citrate binding site [chemical binding]; other site 693216003962 coenzyme A binding site [chemical binding]; other site 693216003963 catalytic triad [active] 693216003964 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 693216003965 Iron-sulfur protein interface; other site 693216003966 proximal quinone binding site [chemical binding]; other site 693216003967 SdhD (CybS) interface [polypeptide binding]; other site 693216003968 proximal heme binding site [chemical binding]; other site 693216003969 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 693216003970 SdhC subunit interface [polypeptide binding]; other site 693216003971 proximal heme binding site [chemical binding]; other site 693216003972 cardiolipin binding site; other site 693216003973 Iron-sulfur protein interface; other site 693216003974 proximal quinone binding site [chemical binding]; other site 693216003975 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 693216003976 L-aspartate oxidase; Provisional; Region: PRK06175 693216003977 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 693216003978 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 693216003979 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 693216003980 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 693216003981 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 693216003982 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 693216003983 TPP-binding site [chemical binding]; other site 693216003984 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 693216003985 dimer interface [polypeptide binding]; other site 693216003986 PYR/PP interface [polypeptide binding]; other site 693216003987 TPP binding site [chemical binding]; other site 693216003988 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 693216003989 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 693216003990 E3 interaction surface; other site 693216003991 lipoyl attachment site [posttranslational modification]; other site 693216003992 e3 binding domain; Region: E3_binding; pfam02817 693216003993 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 693216003994 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 693216003995 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 693216003996 CoA-ligase; Region: Ligase_CoA; pfam00549 693216003997 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 693216003998 CoA binding domain; Region: CoA_binding; pfam02629 693216003999 CoA-ligase; Region: Ligase_CoA; pfam00549 693216004000 DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764 693216004001 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693216004002 DNA-binding site [nucleotide binding]; DNA binding site 693216004003 UTRA domain; Region: UTRA; pfam07702 693216004004 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 693216004005 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 693216004006 active site 693216004007 phosphorylation site [posttranslational modification] 693216004008 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 693216004009 active site 693216004010 P-loop; other site 693216004011 phosphorylation site [posttranslational modification] 693216004012 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 693216004013 alpha-mannosidase; Provisional; Region: PRK09819 693216004014 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 693216004015 active site 693216004016 metal binding site [ion binding]; metal-binding site 693216004017 catalytic site [active] 693216004018 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 693216004019 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 693216004020 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 693216004021 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 693216004022 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 693216004023 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 693216004024 hypothetical protein; Provisional; Region: PRK10588 693216004025 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 693216004026 active site 693216004027 colicin uptake protein TolQ; Provisional; Region: PRK10801 693216004028 colicin uptake protein TolR; Provisional; Region: PRK11024 693216004029 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 693216004030 TolA C-terminal; Region: TolA; pfam06519 693216004031 translocation protein TolB; Provisional; Region: tolB; PRK03629 693216004032 TolB amino-terminal domain; Region: TolB_N; pfam04052 693216004033 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 693216004034 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 693216004035 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 693216004036 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 693216004037 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693216004038 ligand binding site [chemical binding]; other site 693216004039 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 693216004040 Tetratricopeptide repeat; Region: TPR_6; pfam13174 693216004041 Tetratricopeptide repeat; Region: TPR_6; pfam13174 693216004042 quinolinate synthetase; Provisional; Region: PRK09375 693216004043 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 693216004044 zinc transporter ZitB; Provisional; Region: PRK03557 693216004045 YbgS-like protein; Region: YbgS; pfam13985 693216004046 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 693216004047 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 693216004048 catalytic core [active] 693216004049 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 693216004050 active site 693216004051 catalytic residues [active] 693216004052 galactokinase; Provisional; Region: PRK05101 693216004053 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 693216004054 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 693216004055 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 693216004056 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 693216004057 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 693216004058 dimer interface [polypeptide binding]; other site 693216004059 active site 693216004060 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 693216004061 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 693216004062 NAD binding site [chemical binding]; other site 693216004063 homodimer interface [polypeptide binding]; other site 693216004064 active site 693216004065 substrate binding site [chemical binding]; other site 693216004066 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 693216004067 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 693216004068 Walker A/P-loop; other site 693216004069 ATP binding site [chemical binding]; other site 693216004070 Q-loop/lid; other site 693216004071 ABC transporter signature motif; other site 693216004072 Walker B; other site 693216004073 D-loop; other site 693216004074 H-loop/switch region; other site 693216004075 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693216004076 Walker A/P-loop; other site 693216004077 ATP binding site [chemical binding]; other site 693216004078 Q-loop/lid; other site 693216004079 ABC transporter signature motif; other site 693216004080 Walker B; other site 693216004081 D-loop; other site 693216004082 H-loop/switch region; other site 693216004083 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 693216004084 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 693216004085 molybdenum-pterin binding domain; Region: Mop; TIGR00638 693216004086 TOBE domain; Region: TOBE; cl01440 693216004087 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 693216004088 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693216004089 substrate binding pocket [chemical binding]; other site 693216004090 membrane-bound complex binding site; other site 693216004091 hinge residues; other site 693216004092 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 693216004093 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216004094 dimer interface [polypeptide binding]; other site 693216004095 conserved gate region; other site 693216004096 putative PBP binding loops; other site 693216004097 ABC-ATPase subunit interface; other site 693216004098 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 693216004099 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693216004100 Walker A/P-loop; other site 693216004101 ATP binding site [chemical binding]; other site 693216004102 Q-loop/lid; other site 693216004103 ABC transporter signature motif; other site 693216004104 Walker B; other site 693216004105 D-loop; other site 693216004106 H-loop/switch region; other site 693216004107 molybdenum-pterin binding domain; Region: Mop; TIGR00638 693216004108 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 693216004109 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693216004110 active site 693216004111 motif I; other site 693216004112 motif II; other site 693216004113 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 693216004114 6-phosphogluconolactonase; Provisional; Region: PRK11028 693216004115 acyl-CoA thioesterase; Provisional; Region: PRK10531 693216004116 Pectinesterase; Region: Pectinesterase; cl01911 693216004117 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 693216004118 substrate binding site [chemical binding]; other site 693216004119 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 693216004120 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 693216004121 potential catalytic triad [active] 693216004122 conserved cys residue [active] 693216004123 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 693216004124 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693216004125 inhibitor-cofactor binding pocket; inhibition site 693216004126 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216004127 catalytic residue [active] 693216004128 biotin synthase; Provisional; Region: PRK15108 693216004129 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693216004130 FeS/SAM binding site; other site 693216004131 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 693216004132 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 693216004133 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 693216004134 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693216004135 catalytic residue [active] 693216004136 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 693216004137 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693216004138 S-adenosylmethionine binding site [chemical binding]; other site 693216004139 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 693216004140 AAA domain; Region: AAA_26; pfam13500 693216004141 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 693216004142 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693216004143 Walker A/P-loop; other site 693216004144 ATP binding site [chemical binding]; other site 693216004145 Q-loop/lid; other site 693216004146 ABC transporter signature motif; other site 693216004147 Walker B; other site 693216004148 D-loop; other site 693216004149 H-loop/switch region; other site 693216004150 excinuclease ABC subunit B; Provisional; Region: PRK05298 693216004151 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693216004152 ATP binding site [chemical binding]; other site 693216004153 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693216004154 nucleotide binding region [chemical binding]; other site 693216004155 ATP-binding site [chemical binding]; other site 693216004156 Ultra-violet resistance protein B; Region: UvrB; pfam12344 693216004157 UvrB/uvrC motif; Region: UVR; pfam02151 693216004158 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 693216004159 phosphate binding site [ion binding]; other site 693216004160 putative substrate binding pocket [chemical binding]; other site 693216004161 dimer interface [polypeptide binding]; other site 693216004162 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 693216004163 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693216004164 FeS/SAM binding site; other site 693216004165 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 693216004166 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 693216004167 MPT binding site; other site 693216004168 trimer interface [polypeptide binding]; other site 693216004169 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 693216004170 trimer interface [polypeptide binding]; other site 693216004171 dimer interface [polypeptide binding]; other site 693216004172 putative active site [active] 693216004173 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 693216004174 MoaE interaction surface [polypeptide binding]; other site 693216004175 MoeB interaction surface [polypeptide binding]; other site 693216004176 thiocarboxylated glycine; other site 693216004177 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 693216004178 MoaE homodimer interface [polypeptide binding]; other site 693216004179 MoaD interaction [polypeptide binding]; other site 693216004180 active site residues [active] 693216004181 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 693216004182 Predicted integral membrane protein [Function unknown]; Region: COG0392 693216004183 cardiolipin synthase 2; Provisional; Region: PRK11263 693216004184 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 693216004185 putative active site [active] 693216004186 catalytic site [active] 693216004187 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 693216004188 putative active site [active] 693216004189 catalytic site [active] 693216004190 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 693216004191 putative catalytic site [active] 693216004192 putative metal binding site [ion binding]; other site 693216004193 putative phosphate binding site [ion binding]; other site 693216004194 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 693216004195 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 693216004196 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 693216004197 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 693216004198 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 693216004199 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 693216004200 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 693216004201 Walker A/P-loop; other site 693216004202 ATP binding site [chemical binding]; other site 693216004203 Q-loop/lid; other site 693216004204 ABC transporter signature motif; other site 693216004205 Walker B; other site 693216004206 D-loop; other site 693216004207 H-loop/switch region; other site 693216004208 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 693216004209 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 693216004210 Walker A/P-loop; other site 693216004211 ATP binding site [chemical binding]; other site 693216004212 Q-loop/lid; other site 693216004213 ABC transporter signature motif; other site 693216004214 Walker B; other site 693216004215 D-loop; other site 693216004216 H-loop/switch region; other site 693216004217 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 693216004218 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693216004219 HlyD family secretion protein; Region: HlyD_3; pfam13437 693216004220 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 693216004221 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 693216004222 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 693216004223 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 693216004224 ATP binding site [chemical binding]; other site 693216004225 Mg++ binding site [ion binding]; other site 693216004226 motif III; other site 693216004227 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693216004228 nucleotide binding region [chemical binding]; other site 693216004229 ATP-binding site [chemical binding]; other site 693216004230 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 693216004231 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 693216004232 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 693216004233 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 693216004234 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 693216004235 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 693216004236 PapC N-terminal domain; Region: PapC_N; pfam13954 693216004237 Outer membrane usher protein; Region: Usher; pfam00577 693216004238 PapC C-terminal domain; Region: PapC_C; pfam13953 693216004239 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 693216004240 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 693216004241 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 693216004242 Fimbrial protein; Region: Fimbrial; cl01416 693216004243 glycosyl transferase family protein; Provisional; Region: PRK08136 693216004244 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 693216004245 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 693216004246 hypothetical protein; Provisional; Region: PRK11019 693216004247 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 693216004248 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693216004249 S-adenosylmethionine binding site [chemical binding]; other site 693216004250 putative mechanosensitive channel protein; Provisional; Region: PRK11465 693216004251 Mechanosensitive ion channel; Region: MS_channel; pfam00924 693216004252 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 693216004253 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 693216004254 Walker A/P-loop; other site 693216004255 ATP binding site [chemical binding]; other site 693216004256 Q-loop/lid; other site 693216004257 ABC transporter signature motif; other site 693216004258 Walker B; other site 693216004259 D-loop; other site 693216004260 H-loop/switch region; other site 693216004261 glutamine ABC transporter permease protein; Reviewed; Region: glnP; PRK09494 693216004262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216004263 dimer interface [polypeptide binding]; other site 693216004264 conserved gate region; other site 693216004265 putative PBP binding loops; other site 693216004266 ABC-ATPase subunit interface; other site 693216004267 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 693216004268 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693216004269 substrate binding pocket [chemical binding]; other site 693216004270 membrane-bound complex binding site; other site 693216004271 hinge residues; other site 693216004272 Ferritin-like domain; Region: Ferritin; pfam00210 693216004273 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 693216004274 dimerization interface [polypeptide binding]; other site 693216004275 DPS ferroxidase diiron center [ion binding]; other site 693216004276 ion pore; other site 693216004277 threonine and homoserine efflux system; Provisional; Region: PRK10532 693216004278 EamA-like transporter family; Region: EamA; pfam00892 693216004279 outer membrane protein X; Provisional; Region: ompX; PRK09408 693216004280 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 693216004281 Sulfatase; Region: Sulfatase; pfam00884 693216004282 manganese transport regulator MntR; Provisional; Region: PRK11050 693216004283 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 693216004284 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 693216004285 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 693216004286 transmembrane helices; other site 693216004287 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 693216004288 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 693216004289 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216004290 putative substrate translocation pore; other site 693216004291 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 693216004292 Outer membrane efflux protein; Region: OEP; pfam02321 693216004293 Outer membrane efflux protein; Region: OEP; pfam02321 693216004294 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 693216004295 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 693216004296 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 693216004297 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 693216004298 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693216004299 DNA-binding site [nucleotide binding]; DNA binding site 693216004300 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 693216004301 L,D-transpeptidase; Provisional; Region: PRK10260 693216004302 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 693216004303 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 693216004304 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693216004305 ABC transporter; Region: ABC_tran_2; pfam12848 693216004306 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693216004307 haemagglutination activity domain; Region: Haemagg_act; pfam05860 693216004308 Protein of unknown function (DUF342); Region: DUF342; cl19219 693216004309 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 693216004310 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 693216004311 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 693216004312 putative active site [active] 693216004313 putative catalytic site [active] 693216004314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216004315 D-galactonate transporter; Region: 2A0114; TIGR00893 693216004316 putative substrate translocation pore; other site 693216004317 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693216004318 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693216004319 DNA binding site [nucleotide binding] 693216004320 domain linker motif; other site 693216004321 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 693216004322 ligand binding site [chemical binding]; other site 693216004323 dimerization interface [polypeptide binding]; other site 693216004324 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 693216004325 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 693216004326 ATP binding site [chemical binding]; other site 693216004327 substrate interface [chemical binding]; other site 693216004328 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 693216004329 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 693216004330 dimer interface [polypeptide binding]; other site 693216004331 putative functional site; other site 693216004332 putative MPT binding site; other site 693216004333 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 693216004334 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693216004335 Walker A/P-loop; other site 693216004336 ATP binding site [chemical binding]; other site 693216004337 Q-loop/lid; other site 693216004338 ABC transporter signature motif; other site 693216004339 Walker B; other site 693216004340 D-loop; other site 693216004341 H-loop/switch region; other site 693216004342 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693216004343 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693216004344 Walker A/P-loop; other site 693216004345 ATP binding site [chemical binding]; other site 693216004346 Q-loop/lid; other site 693216004347 ABC transporter signature motif; other site 693216004348 Walker B; other site 693216004349 D-loop; other site 693216004350 H-loop/switch region; other site 693216004351 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693216004352 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693216004353 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 693216004354 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 693216004355 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216004356 dimer interface [polypeptide binding]; other site 693216004357 conserved gate region; other site 693216004358 putative PBP binding loops; other site 693216004359 ABC-ATPase subunit interface; other site 693216004360 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 693216004361 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 693216004362 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216004363 dimer interface [polypeptide binding]; other site 693216004364 conserved gate region; other site 693216004365 putative PBP binding loops; other site 693216004366 ABC-ATPase subunit interface; other site 693216004367 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 693216004368 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 693216004369 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693216004370 FeS/SAM binding site; other site 693216004371 TRAM domain; Region: TRAM; cl01282 693216004372 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 693216004373 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 693216004374 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 693216004375 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 693216004376 putative C-terminal domain interface [polypeptide binding]; other site 693216004377 putative GSH binding site (G-site) [chemical binding]; other site 693216004378 putative dimer interface [polypeptide binding]; other site 693216004379 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 693216004380 N-terminal domain interface [polypeptide binding]; other site 693216004381 dimer interface [polypeptide binding]; other site 693216004382 substrate binding pocket (H-site) [chemical binding]; other site 693216004383 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 693216004384 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 693216004385 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 693216004386 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 693216004387 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 693216004388 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 693216004389 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 693216004390 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 693216004391 active site 693216004392 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 693216004393 active site 693216004394 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 693216004395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216004396 putative substrate translocation pore; other site 693216004397 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 693216004398 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693216004399 active site 693216004400 motif I; other site 693216004401 motif II; other site 693216004402 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693216004403 flagellin; Validated; Region: PRK06819 693216004404 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 693216004405 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 693216004406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216004407 putative substrate translocation pore; other site 693216004408 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693216004409 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 693216004410 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693216004411 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 693216004412 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 693216004413 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 693216004414 potential frameshift: common BLAST hit: gi|218700171|ref|YP_002407800.1| phage portal protein 693216004415 Phage portal protein; Region: Phage_portal; cl19194 693216004416 Phage portal protein; Region: Phage_portal; cl19194 693216004417 putative transporter; Provisional; Region: PRK04972 693216004418 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 693216004419 TrkA-C domain; Region: TrkA_C; pfam02080 693216004420 TrkA-C domain; Region: TrkA_C; pfam02080 693216004421 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 693216004422 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 693216004423 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 693216004424 dimer interface [polypeptide binding]; other site 693216004425 FMN binding site [chemical binding]; other site 693216004426 NADPH bind site [chemical binding]; other site 693216004427 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 693216004428 RimK-like ATP-grasp domain; Region: RimK; pfam08443 693216004429 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 693216004430 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 693216004431 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 693216004432 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 693216004433 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693216004434 Walker A/P-loop; other site 693216004435 ATP binding site [chemical binding]; other site 693216004436 Q-loop/lid; other site 693216004437 ABC transporter signature motif; other site 693216004438 Walker B; other site 693216004439 D-loop; other site 693216004440 H-loop/switch region; other site 693216004441 TOBE domain; Region: TOBE_2; pfam08402 693216004442 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 693216004443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216004444 dimer interface [polypeptide binding]; other site 693216004445 conserved gate region; other site 693216004446 putative PBP binding loops; other site 693216004447 ABC-ATPase subunit interface; other site 693216004448 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 693216004449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216004450 dimer interface [polypeptide binding]; other site 693216004451 conserved gate region; other site 693216004452 putative PBP binding loops; other site 693216004453 ABC-ATPase subunit interface; other site 693216004454 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 693216004455 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 693216004456 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693216004457 S-adenosylmethionine binding site [chemical binding]; other site 693216004458 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 693216004459 galactoside permease; Reviewed; Region: lacY; PRK09528 693216004460 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216004461 putative substrate translocation pore; other site 693216004462 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 693216004463 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 693216004464 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 693216004465 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693216004466 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693216004467 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 693216004468 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693216004469 substrate binding pocket [chemical binding]; other site 693216004470 membrane-bound complex binding site; other site 693216004471 hinge residues; other site 693216004472 arginine transporter permease subunit ArtM; Provisional; Region: artM; PRK11122 693216004473 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216004474 dimer interface [polypeptide binding]; other site 693216004475 conserved gate region; other site 693216004476 putative PBP binding loops; other site 693216004477 ABC-ATPase subunit interface; other site 693216004478 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 693216004479 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216004480 dimer interface [polypeptide binding]; other site 693216004481 conserved gate region; other site 693216004482 putative PBP binding loops; other site 693216004483 ABC-ATPase subunit interface; other site 693216004484 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 693216004485 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693216004486 substrate binding pocket [chemical binding]; other site 693216004487 membrane-bound complex binding site; other site 693216004488 hinge residues; other site 693216004489 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 693216004490 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693216004491 Walker A/P-loop; other site 693216004492 ATP binding site [chemical binding]; other site 693216004493 Q-loop/lid; other site 693216004494 ABC transporter signature motif; other site 693216004495 Walker B; other site 693216004496 D-loop; other site 693216004497 H-loop/switch region; other site 693216004498 putative lipoprotein; Provisional; Region: PRK10533 693216004499 hypothetical protein; Provisional; Region: PRK02877 693216004500 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 693216004501 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 693216004502 amidase catalytic site [active] 693216004503 Zn binding residues [ion binding]; other site 693216004504 substrate binding site [chemical binding]; other site 693216004505 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 693216004506 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693216004507 NAD(P) binding site [chemical binding]; other site 693216004508 active site 693216004509 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 693216004510 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 693216004511 tetramer interface [polypeptide binding]; other site 693216004512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216004513 catalytic residue [active] 693216004514 pyruvate dehydrogenase; Provisional; Region: PRK09124 693216004515 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 693216004516 PYR/PP interface [polypeptide binding]; other site 693216004517 dimer interface [polypeptide binding]; other site 693216004518 tetramer interface [polypeptide binding]; other site 693216004519 TPP binding site [chemical binding]; other site 693216004520 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 693216004521 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 693216004522 TPP-binding site [chemical binding]; other site 693216004523 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 693216004524 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 693216004525 FAD binding pocket [chemical binding]; other site 693216004526 FAD binding motif [chemical binding]; other site 693216004527 phosphate binding motif [ion binding]; other site 693216004528 beta-alpha-beta structure motif; other site 693216004529 NAD binding pocket [chemical binding]; other site 693216004530 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693216004531 catalytic loop [active] 693216004532 iron binding site [ion binding]; other site 693216004533 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 693216004534 cubane metal cluster [ion binding]; other site 693216004535 hybrid metal cluster; other site 693216004536 Predicted membrane protein [Function unknown]; Region: COG2431 693216004537 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 693216004538 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 693216004539 putative active site [active] 693216004540 putative metal-binding site [ion binding]; other site 693216004541 Protein of unknown function (DUF535); Region: DUF535; pfam04393 693216004542 macrolide transporter subunit MacA; Provisional; Region: PRK11578 693216004543 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693216004544 HlyD family secretion protein; Region: HlyD_3; pfam13437 693216004545 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 693216004546 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 693216004547 Walker A/P-loop; other site 693216004548 ATP binding site [chemical binding]; other site 693216004549 Q-loop/lid; other site 693216004550 ABC transporter signature motif; other site 693216004551 Walker B; other site 693216004552 D-loop; other site 693216004553 H-loop/switch region; other site 693216004554 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 693216004555 FtsX-like permease family; Region: FtsX; pfam02687 693216004556 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 693216004557 DNA-binding site [nucleotide binding]; DNA binding site 693216004558 RNA-binding motif; other site 693216004559 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 693216004560 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 693216004561 Clp amino terminal domain; Region: Clp_N; pfam02861 693216004562 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693216004563 Walker A motif; other site 693216004564 ATP binding site [chemical binding]; other site 693216004565 Walker B motif; other site 693216004566 arginine finger; other site 693216004567 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693216004568 Walker A motif; other site 693216004569 ATP binding site [chemical binding]; other site 693216004570 Walker B motif; other site 693216004571 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 693216004572 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 693216004573 rRNA binding site [nucleotide binding]; other site 693216004574 predicted 30S ribosome binding site; other site 693216004575 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 693216004576 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 693216004577 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693216004578 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 693216004579 Walker A/P-loop; other site 693216004580 ATP binding site [chemical binding]; other site 693216004581 Q-loop/lid; other site 693216004582 ABC transporter signature motif; other site 693216004583 Walker B; other site 693216004584 D-loop; other site 693216004585 H-loop/switch region; other site 693216004586 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 693216004587 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693216004588 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693216004589 Walker A/P-loop; other site 693216004590 ATP binding site [chemical binding]; other site 693216004591 Q-loop/lid; other site 693216004592 ABC transporter signature motif; other site 693216004593 Walker B; other site 693216004594 D-loop; other site 693216004595 H-loop/switch region; other site 693216004596 thioredoxin reductase; Provisional; Region: PRK10262 693216004597 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 693216004598 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693216004599 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 693216004600 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 693216004601 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693216004602 putative DNA binding site [nucleotide binding]; other site 693216004603 putative Zn2+ binding site [ion binding]; other site 693216004604 AsnC family; Region: AsnC_trans_reg; pfam01037 693216004605 DNA translocase FtsK; Provisional; Region: PRK10263 693216004606 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 693216004607 hypothetical protein; Provisional; Region: PHA03160 693216004608 YppG-like protein; Region: YppG; pfam14179 693216004609 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 693216004610 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 693216004611 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 693216004612 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl19192 693216004613 recombination factor protein RarA; Reviewed; Region: PRK13342 693216004614 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693216004615 Walker A motif; other site 693216004616 ATP binding site [chemical binding]; other site 693216004617 Walker B motif; other site 693216004618 arginine finger; other site 693216004619 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 693216004620 seryl-tRNA synthetase; Provisional; Region: PRK05431 693216004621 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 693216004622 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 693216004623 dimer interface [polypeptide binding]; other site 693216004624 active site 693216004625 motif 1; other site 693216004626 motif 2; other site 693216004627 motif 3; other site 693216004628 putative MFS family transporter protein; Provisional; Region: PRK03633 693216004629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216004630 putative substrate translocation pore; other site 693216004631 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 693216004632 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693216004633 FeS/SAM binding site; other site 693216004634 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 693216004635 Pyruvate formate lyase 1; Region: PFL1; cd01678 693216004636 coenzyme A binding site [chemical binding]; other site 693216004637 active site 693216004638 catalytic residues [active] 693216004639 glycine loop; other site 693216004640 formate transporter; Provisional; Region: PRK10805 693216004641 uncharacterized domain; Region: TIGR00702 693216004642 Predicted membrane protein [Function unknown]; Region: COG2323 693216004643 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 693216004644 homodimer interface [polypeptide binding]; other site 693216004645 substrate-cofactor binding pocket; other site 693216004646 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216004647 catalytic residue [active] 693216004648 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 693216004649 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 693216004650 hinge; other site 693216004651 active site 693216004652 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 693216004653 cytidylate kinase; Provisional; Region: cmk; PRK00023 693216004654 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 693216004655 CMP-binding site; other site 693216004656 The sites determining sugar specificity; other site 693216004657 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 693216004658 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 693216004659 RNA binding site [nucleotide binding]; other site 693216004660 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 693216004661 RNA binding site [nucleotide binding]; other site 693216004662 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 693216004663 RNA binding site [nucleotide binding]; other site 693216004664 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 693216004665 RNA binding site [nucleotide binding]; other site 693216004666 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 693216004667 RNA binding site [nucleotide binding]; other site 693216004668 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 693216004669 RNA binding site [nucleotide binding]; other site 693216004670 Beta subunit of integration host factor (IHFB); Region: IHF_B; cd13836 693216004671 dimer interface [polypeptide binding]; other site 693216004672 DNA binding site [nucleotide binding] 693216004673 ComEC family competence protein; Provisional; Region: PRK11539 693216004674 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 693216004675 Competence protein; Region: Competence; pfam03772 693216004676 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 693216004677 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 693216004678 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693216004679 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 693216004680 Walker A/P-loop; other site 693216004681 ATP binding site [chemical binding]; other site 693216004682 Q-loop/lid; other site 693216004683 ABC transporter signature motif; other site 693216004684 Walker B; other site 693216004685 D-loop; other site 693216004686 H-loop/switch region; other site 693216004687 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 693216004688 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 693216004689 Trm112p-like protein; Region: Trm112p; cl01066 693216004690 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 693216004691 Ligand binding site; other site 693216004692 oligomer interface; other site 693216004693 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 693216004694 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693216004695 dimerization interface [polypeptide binding]; other site 693216004696 putative DNA binding site [nucleotide binding]; other site 693216004697 putative Zn2+ binding site [ion binding]; other site 693216004698 AsnC family; Region: AsnC_trans_reg; pfam01037 693216004699 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 693216004700 hypothetical protein; Provisional; Region: PRK10593 693216004701 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 693216004702 putative active site [active] 693216004703 Methyltransferase domain; Region: Methyltransf_31; pfam13847 693216004704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693216004705 S-adenosylmethionine binding site [chemical binding]; other site 693216004706 condesin subunit F; Provisional; Region: PRK05260 693216004707 condesin subunit E; Provisional; Region: PRK05256 693216004708 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 693216004709 P-loop containing region of AAA domain; Region: AAA_29; cl17516 693216004710 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 693216004711 murein L,D-transpeptidase; Provisional; Region: PRK10594 693216004712 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 693216004713 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 693216004714 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 693216004715 Peptidase M15; Region: Peptidase_M15_3; cl01194 693216004716 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 693216004717 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 693216004718 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693216004719 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216004720 homodimer interface [polypeptide binding]; other site 693216004721 catalytic residue [active] 693216004722 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 693216004723 trimer interface [polypeptide binding]; other site 693216004724 eyelet of channel; other site 693216004725 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 693216004726 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 693216004727 putative dimer interface [polypeptide binding]; other site 693216004728 putative anticodon binding site; other site 693216004729 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 693216004730 homodimer interface [polypeptide binding]; other site 693216004731 motif 1; other site 693216004732 motif 2; other site 693216004733 active site 693216004734 motif 3; other site 693216004735 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 693216004736 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 693216004737 active site 693216004738 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 693216004739 RNA polymerase sigma factor; Provisional; Region: PRK12511 693216004740 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693216004741 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693216004742 DNA binding residues [nucleotide binding] 693216004743 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 693216004744 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 693216004745 putative heme binding pocket [chemical binding]; other site 693216004746 aminopeptidase N; Provisional; Region: pepN; PRK14015 693216004747 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 693216004748 active site 693216004749 Zn binding site [ion binding]; other site 693216004750 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 693216004751 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 693216004752 Walker A/P-loop; other site 693216004753 ATP binding site [chemical binding]; other site 693216004754 Q-loop/lid; other site 693216004755 ABC transporter signature motif; other site 693216004756 Walker B; other site 693216004757 D-loop; other site 693216004758 H-loop/switch region; other site 693216004759 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 693216004760 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216004761 dimer interface [polypeptide binding]; other site 693216004762 conserved gate region; other site 693216004763 putative PBP binding loops; other site 693216004764 ABC-ATPase subunit interface; other site 693216004765 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 693216004766 active site 693216004767 dimer interface [polypeptide binding]; other site 693216004768 non-prolyl cis peptide bond; other site 693216004769 insertion regions; other site 693216004770 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 693216004771 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693216004772 substrate binding pocket [chemical binding]; other site 693216004773 membrane-bound complex binding site; other site 693216004774 hinge residues; other site 693216004775 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 693216004776 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 693216004777 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 693216004778 quinone interaction residues [chemical binding]; other site 693216004779 active site 693216004780 catalytic residues [active] 693216004781 FMN binding site [chemical binding]; other site 693216004782 substrate binding site [chemical binding]; other site 693216004783 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 693216004784 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 693216004785 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 693216004786 MOSC domain; Region: MOSC; pfam03473 693216004787 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693216004788 catalytic loop [active] 693216004789 iron binding site [ion binding]; other site 693216004790 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 693216004791 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 693216004792 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 693216004793 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693216004794 S-adenosylmethionine binding site [chemical binding]; other site 693216004795 ABC transporter ATPase component; Reviewed; Region: PRK11147 693216004796 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693216004797 ABC transporter; Region: ABC_tran_2; pfam12848 693216004798 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693216004799 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 693216004800 Paraquat-inducible protein A; Region: PqiA; pfam04403 693216004801 Paraquat-inducible protein A; Region: PqiA; pfam04403 693216004802 paraquat-inducible protein B; Provisional; Region: PRK10807 693216004803 mce related protein; Region: MCE; pfam02470 693216004804 mce related protein; Region: MCE; pfam02470 693216004805 mce related protein; Region: MCE; pfam02470 693216004806 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 693216004807 ribosome modulation factor; Provisional; Region: PRK14563 693216004808 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 693216004809 active site 1 [active] 693216004810 dimer interface [polypeptide binding]; other site 693216004811 active site 2 [active] 693216004812 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 693216004813 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 693216004814 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 693216004815 outer membrane protein A; Reviewed; Region: PRK10808 693216004816 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 693216004817 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693216004818 ligand binding site [chemical binding]; other site 693216004819 SOS cell division inhibitor; Provisional; Region: PRK10595 693216004820 TfoX N-terminal domain; Region: TfoX_N; pfam04993 693216004821 TfoX C-terminal domain; Region: TfoX_C; pfam04994 693216004822 TIGR01666 family membrane protein; Region: YCCS 693216004823 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 693216004824 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 693216004825 Prefoldin subunit; Region: Prefoldin_2; pfam01920 693216004826 hypothetical protein; Provisional; Region: PRK11770 693216004827 Domain of unknown function (DUF307); Region: DUF307; pfam03733 693216004828 Domain of unknown function (DUF307); Region: DUF307; pfam03733 693216004829 DNA helicase IV; Provisional; Region: helD; PRK11054 693216004830 DNA helicase IV / RNA helicase N terminal; Region: Helicase_IV_N; pfam12462 693216004831 Part of AAA domain; Region: AAA_19; pfam13245 693216004832 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 693216004833 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 693216004834 active site 693216004835 dimer interfaces [polypeptide binding]; other site 693216004836 catalytic residues [active] 693216004837 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 693216004838 heat shock protein HspQ; Provisional; Region: PRK14129 693216004839 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 693216004840 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 693216004841 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 693216004842 putative RNA binding site [nucleotide binding]; other site 693216004843 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693216004844 S-adenosylmethionine binding site [chemical binding]; other site 693216004845 acylphosphatase; Provisional; Region: PRK14426 693216004846 sulfur transfer protein TusE; Provisional; Region: PRK11508 693216004847 YccA-like proteins; Region: YccA_like; cd10433 693216004848 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 693216004849 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 693216004850 peptide binding site [polypeptide binding]; other site 693216004851 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 693216004852 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 693216004853 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 693216004854 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 693216004855 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 693216004856 ImpA domain protein; Region: DUF3702; pfam12486 693216004857 hypothetical protein; Provisional; Region: PRK10174 693216004858 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 693216004859 Sulfate transporter family; Region: Sulfate_transp; cl19250 693216004860 uracil-xanthine permease; Region: ncs2; TIGR00801 693216004861 Flavin Reductases; Region: FlaRed; cl00801 693216004862 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 693216004863 putative FMN binding site [chemical binding]; other site 693216004864 pyrimidine utilization protein D; Region: RutD; TIGR03611 693216004865 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 693216004866 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 693216004867 homotrimer interaction site [polypeptide binding]; other site 693216004868 putative active site [active] 693216004869 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 693216004870 catalytic triad [active] 693216004871 conserved cis-peptide bond; other site 693216004872 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 693216004873 active site 693216004874 dimer interface [polypeptide binding]; other site 693216004875 non-prolyl cis peptide bond; other site 693216004876 insertion regions; other site 693216004877 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 693216004878 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 693216004879 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693216004880 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 693216004881 Protein of unknown function (DUF3289); Region: DUF3289; pfam11692 693216004882 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 693216004883 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 693216004884 Predicted transcriptional regulator [Transcription]; Region: COG3905 693216004885 DNA-binding domain of Proline dehydrogenase; Region: Pro_dh-DNA_bdg; pfam14850 693216004886 Proline dehydrogenase; Region: Pro_dh; pfam01619 693216004887 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 693216004888 Glutamate binding site [chemical binding]; other site 693216004889 NAD binding site [chemical binding]; other site 693216004890 catalytic residues [active] 693216004891 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 693216004892 Na binding site [ion binding]; other site 693216004893 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 693216004894 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 693216004895 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 693216004896 Nucleoside recognition; Region: Gate; pfam07670 693216004897 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 693216004898 Iron permease FTR1 family; Region: FTR1; cl00475 693216004899 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 693216004900 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 693216004901 Imelysin; Region: Peptidase_M75; pfam09375 693216004902 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 693216004903 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 693216004904 hypothetical protein; Provisional; Region: PRK10536 693216004905 putative oxidoreductase; Provisional; Region: PRK09939 693216004906 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 693216004907 putative molybdopterin cofactor binding site [chemical binding]; other site 693216004908 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 693216004909 putative molybdopterin cofactor binding site; other site 693216004910 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 693216004911 fimbrial chaperone protein StiB; Provisional; Region: PRK15299 693216004912 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 693216004913 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 693216004914 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 693216004915 PapC N-terminal domain; Region: PapC_N; pfam13954 693216004916 Outer membrane usher protein; Region: Usher; pfam00577 693216004917 PapC C-terminal domain; Region: PapC_C; pfam13953 693216004918 Fimbrial protein; Region: Fimbrial; cl01416 693216004919 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 693216004920 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 693216004921 putative ligand binding site [chemical binding]; other site 693216004922 NAD binding site [chemical binding]; other site 693216004923 dimerization interface [polypeptide binding]; other site 693216004924 catalytic site [active] 693216004925 putative hydrolase; Validated; Region: PRK09248 693216004926 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 693216004927 active site 693216004928 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 693216004929 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 693216004930 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 693216004931 curli assembly protein CsgF; Provisional; Region: PRK10050 693216004932 curli assembly protein CsgE; Provisional; Region: PRK10386 693216004933 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 693216004934 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693216004935 DNA binding residues [nucleotide binding] 693216004936 dimerization interface [polypeptide binding]; other site 693216004937 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 693216004938 major curlin subunit; Provisional; Region: csgA; PRK10051 693216004939 major curlin subunit; Provisional; Region: csgA; PRK10051 693216004940 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 693216004941 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 693216004942 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 693216004943 putative ADP-ribose binding site [chemical binding]; other site 693216004944 putative active site [active] 693216004945 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 693216004946 PLD-like domain; Region: PLDc_2; pfam13091 693216004947 putative active site [active] 693216004948 catalytic site [active] 693216004949 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 693216004950 PLD-like domain; Region: PLDc_2; pfam13091 693216004951 putative active site [active] 693216004952 catalytic site [active] 693216004953 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 693216004954 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 693216004955 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 693216004956 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 693216004957 Ligand binding site; other site 693216004958 DXD motif; other site 693216004959 lipoprotein; Provisional; Region: PRK10175 693216004960 secY/secA suppressor protein; Provisional; Region: PRK11467 693216004961 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 693216004962 putative acyl-acceptor binding pocket; other site 693216004963 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 693216004964 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 693216004965 active site residue [active] 693216004966 hypothetical protein; Provisional; Region: PRK03757 693216004967 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 693216004968 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 693216004969 FAD dependent oxidoreductase; Region: DAO; pfam01266 693216004970 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 693216004971 DinI-like family; Region: DinI; cl11630 693216004972 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 693216004973 active site 693216004974 substrate binding pocket [chemical binding]; other site 693216004975 dimer interface [polypeptide binding]; other site 693216004976 lipoprotein; Provisional; Region: PRK10598 693216004977 glutaredoxin 2; Provisional; Region: PRK10387 693216004978 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 693216004979 C-terminal domain interface [polypeptide binding]; other site 693216004980 GSH binding site (G-site) [chemical binding]; other site 693216004981 catalytic residues [active] 693216004982 putative dimer interface [polypeptide binding]; other site 693216004983 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 693216004984 N-terminal domain interface [polypeptide binding]; other site 693216004985 multidrug resistance protein MdtH; Provisional; Region: PRK11646 693216004986 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216004987 putative substrate translocation pore; other site 693216004988 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 693216004989 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 693216004990 hypothetical protein; Provisional; Region: PRK11239 693216004991 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 693216004992 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693216004993 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 693216004994 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 693216004995 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 693216004996 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 693216004997 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 693216004998 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 693216004999 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 693216005000 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 693216005001 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 693216005002 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 693216005003 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 693216005004 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 693216005005 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 693216005006 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 693216005007 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 693216005008 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 693216005009 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 693216005010 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 693216005011 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 693216005012 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 693216005013 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 693216005014 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 693216005015 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 693216005016 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 693216005017 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 693216005018 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 693216005019 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 693216005020 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 693216005021 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 693216005022 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 693216005023 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 693216005024 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 693216005025 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 693216005026 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 693216005027 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 693216005028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216005029 putative substrate translocation pore; other site 693216005030 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693216005031 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216005032 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693216005033 putative effector binding pocket; other site 693216005034 dimerization interface [polypeptide binding]; other site 693216005035 ribonuclease E; Reviewed; Region: rne; PRK10811 693216005036 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 693216005037 homodimer interface [polypeptide binding]; other site 693216005038 oligonucleotide binding site [chemical binding]; other site 693216005039 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 693216005040 Mitochondria Localisation Sequence; Region: AIF-MLS; pfam14962 693216005041 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 693216005042 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 693216005043 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693216005044 RNA binding surface [nucleotide binding]; other site 693216005045 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 693216005046 active site 693216005047 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 693216005048 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 693216005049 active site 693216005050 dimer interface [polypeptide binding]; other site 693216005051 hypothetical protein; Provisional; Region: PRK11193 693216005052 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 693216005053 putative phosphate acyltransferase; Provisional; Region: PRK05331 693216005054 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 693216005055 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 693216005056 dimer interface [polypeptide binding]; other site 693216005057 active site 693216005058 CoA binding pocket [chemical binding]; other site 693216005059 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 693216005060 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 693216005061 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 693216005062 NAD(P) binding site [chemical binding]; other site 693216005063 homotetramer interface [polypeptide binding]; other site 693216005064 homodimer interface [polypeptide binding]; other site 693216005065 active site 693216005066 acyl carrier protein; Provisional; Region: acpP; PRK00982 693216005067 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 693216005068 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 693216005069 dimer interface [polypeptide binding]; other site 693216005070 active site 693216005071 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 693216005072 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216005073 catalytic residue [active] 693216005074 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 693216005075 dimerization interface [polypeptide binding]; other site 693216005076 thymidylate kinase; Validated; Region: tmk; PRK00698 693216005077 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 693216005078 TMP-binding site; other site 693216005079 ATP-binding site [chemical binding]; other site 693216005080 DNA polymerase III subunit delta'; Validated; Region: PRK07993 693216005081 DNA polymerase III subunit delta'; Validated; Region: PRK08485 693216005082 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 693216005083 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 693216005084 active site 693216005085 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 693216005086 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 693216005087 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 693216005088 active site turn [active] 693216005089 phosphorylation site [posttranslational modification] 693216005090 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 693216005091 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693216005092 N-terminal plug; other site 693216005093 ligand-binding site [chemical binding]; other site 693216005094 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 693216005095 nucleotide binding site/active site [active] 693216005096 HIT family signature motif; other site 693216005097 catalytic residue [active] 693216005098 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 693216005099 putative dimer interface [polypeptide binding]; other site 693216005100 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 693216005101 Phosphotransferase enzyme family; Region: APH; pfam01636 693216005102 thiamine kinase; Provisional; Region: thiK; PRK10271 693216005103 beta-hexosaminidase; Provisional; Region: PRK05337 693216005104 hypothetical protein; Provisional; Region: PRK04940 693216005105 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 693216005106 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693216005107 hypothetical protein; Provisional; Region: PRK11280 693216005108 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693216005109 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693216005110 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 693216005111 L,D-transpeptidase; Provisional; Region: PRK10260 693216005112 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693216005113 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 693216005114 transcription-repair coupling factor; Provisional; Region: PRK10689 693216005115 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 693216005116 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 693216005117 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693216005118 ATP binding site [chemical binding]; other site 693216005119 putative Mg++ binding site [ion binding]; other site 693216005120 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693216005121 nucleotide binding region [chemical binding]; other site 693216005122 ATP-binding site [chemical binding]; other site 693216005123 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 693216005124 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 693216005125 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 693216005126 FtsX-like permease family; Region: FtsX; pfam02687 693216005127 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 693216005128 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 693216005129 Walker A/P-loop; other site 693216005130 ATP binding site [chemical binding]; other site 693216005131 Q-loop/lid; other site 693216005132 ABC transporter signature motif; other site 693216005133 Walker B; other site 693216005134 D-loop; other site 693216005135 H-loop/switch region; other site 693216005136 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 693216005137 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 693216005138 FtsX-like permease family; Region: FtsX; pfam02687 693216005139 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 693216005140 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 693216005141 nucleotide binding site [chemical binding]; other site 693216005142 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 693216005143 NAD+ binding site [chemical binding]; other site 693216005144 substrate binding site [chemical binding]; other site 693216005145 Zn binding site [ion binding]; other site 693216005146 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 693216005147 spermidine/putrescine ABC transporter membrane protein; Reviewed; Region: potC; PRK09500 693216005148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216005149 dimer interface [polypeptide binding]; other site 693216005150 conserved gate region; other site 693216005151 putative PBP binding loops; other site 693216005152 ABC-ATPase subunit interface; other site 693216005153 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 693216005154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216005155 dimer interface [polypeptide binding]; other site 693216005156 conserved gate region; other site 693216005157 putative PBP binding loops; other site 693216005158 ABC-ATPase subunit interface; other site 693216005159 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 693216005160 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 693216005161 Walker A/P-loop; other site 693216005162 ATP binding site [chemical binding]; other site 693216005163 Q-loop/lid; other site 693216005164 ABC transporter signature motif; other site 693216005165 Walker B; other site 693216005166 D-loop; other site 693216005167 H-loop/switch region; other site 693216005168 TOBE domain; Region: TOBE_2; pfam08402 693216005169 peptidase T-like protein; Region: PepT-like; TIGR01883 693216005170 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 693216005171 metal binding site [ion binding]; metal-binding site 693216005172 dimer interface [polypeptide binding]; other site 693216005173 Uncharacterized conserved protein [Function unknown]; Region: COG2850 693216005174 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 693216005175 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 693216005176 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 693216005177 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693216005178 ATP binding site [chemical binding]; other site 693216005179 Mg2+ binding site [ion binding]; other site 693216005180 G-X-G motif; other site 693216005181 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 693216005182 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693216005183 active site 693216005184 phosphorylation site [posttranslational modification] 693216005185 intermolecular recognition site; other site 693216005186 dimerization interface [polypeptide binding]; other site 693216005187 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693216005188 DNA binding site [nucleotide binding] 693216005189 adenylosuccinate lyase; Provisional; Region: PRK09285 693216005190 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 693216005191 tetramer interface [polypeptide binding]; other site 693216005192 active site 693216005193 putative lysogenization regulator; Reviewed; Region: PRK00218 693216005194 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 693216005195 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 693216005196 Ligand Binding Site [chemical binding]; other site 693216005197 Cache domain; Region: Cache_1; pfam02743 693216005198 HAMP domain; Region: HAMP; pfam00672 693216005199 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693216005200 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693216005201 dimer interface [polypeptide binding]; other site 693216005202 putative CheW interface [polypeptide binding]; other site 693216005203 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 693216005204 nudix motif; other site 693216005205 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 693216005206 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 693216005207 probable active site [active] 693216005208 isocitrate dehydrogenase; Reviewed; Region: PRK07006 693216005209 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 693216005210 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 693216005211 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 693216005212 dimer interface [polypeptide binding]; other site 693216005213 active site 693216005214 Int/Topo IB signature motif; other site 693216005215 Alpha helical coiled-coil rod protein (HCR); Region: HCR; pfam07111 693216005216 Predicted transcriptional regulator [Transcription]; Region: COG2932 693216005217 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693216005218 non-specific DNA binding site [nucleotide binding]; other site 693216005219 salt bridge; other site 693216005220 sequence-specific DNA binding site [nucleotide binding]; other site 693216005221 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 693216005222 Catalytic site [active] 693216005223 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693216005224 non-specific DNA binding site [nucleotide binding]; other site 693216005225 salt bridge; other site 693216005226 sequence-specific DNA binding site [nucleotide binding]; other site 693216005227 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 693216005228 Helix-turn-helix domain; Region: HTH_36; pfam13730 693216005229 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 693216005230 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 693216005231 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 693216005232 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 693216005233 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 693216005234 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 693216005235 Protein of unknown function (DUF968); Region: DUF968; pfam06147 693216005236 Antitermination protein; Region: Antiterm; pfam03589 693216005237 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cl19048 693216005238 Antitermination protein; Region: Antiterm; pfam03589 693216005239 Protein of unknown function (DUF754); Region: DUF754; pfam05449 693216005240 Predicted chitinase [General function prediction only]; Region: COG3179 693216005241 catalytic residue [active] 693216005242 Bacteriophage Rz lysis protein; Region: Phage_lysis; pfam03245 693216005243 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 693216005244 active site 693216005245 Phage terminase, small subunit; Region: Terminase_4; cl01525 693216005246 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 693216005247 Phage Terminase; Region: Terminase_1; cl19862 693216005248 Phage portal protein; Region: Phage_portal; pfam04860 693216005249 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 693216005250 oligomer interface [polypeptide binding]; other site 693216005251 active site residues [active] 693216005252 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 693216005253 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 693216005254 Phage capsid family; Region: Phage_capsid; pfam05065 693216005255 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 693216005256 oligomerization interface [polypeptide binding]; other site 693216005257 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 693216005258 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 693216005259 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 693216005260 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 693216005261 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 693216005262 Phage-related minor tail protein [Function unknown]; Region: COG5281 693216005263 tape measure domain; Region: tape_meas_nterm; TIGR02675 693216005264 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; cl19901 693216005265 Phage minor tail protein; Region: Phage_min_tail; pfam05939 693216005266 Phage-related protein [Function unknown]; Region: gp18; COG4672 693216005267 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 693216005268 MPN+ (JAMM) motif; other site 693216005269 Zinc-binding site [ion binding]; other site 693216005270 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 693216005271 NlpC/P60 family; Region: NLPC_P60; cl17555 693216005272 Phage-related protein, tail component [Function unknown]; Region: COG4723 693216005273 Phage-related protein, tail component [Function unknown]; Region: COG4733 693216005274 Putative phage tail protein; Region: Phage-tail_3; pfam13550 693216005275 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 693216005276 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 693216005277 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 693216005278 Catalytic site [active] 693216005279 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 693216005280 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 693216005281 active site 693216005282 DNA binding site [nucleotide binding] 693216005283 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 693216005284 Restriction endonuclease; Region: Mrr_cat; pfam04471 693216005285 Archaeal adenylate kinase [Nucleotide transport and metabolism]; Region: AdkA; cl17890 693216005286 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 693216005287 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693216005288 salt bridge; other site 693216005289 non-specific DNA binding site [nucleotide binding]; other site 693216005290 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693216005291 sequence-specific DNA binding site [nucleotide binding]; other site 693216005292 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 693216005293 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 693216005294 putative NAD(P) binding site [chemical binding]; other site 693216005295 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 693216005296 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 693216005297 active site 693216005298 metal binding site [ion binding]; metal-binding site 693216005299 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 693216005300 dimer interface [polypeptide binding]; other site 693216005301 ligand binding site [chemical binding]; other site 693216005302 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693216005303 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693216005304 dimerization interface [polypeptide binding]; other site 693216005305 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693216005306 dimer interface [polypeptide binding]; other site 693216005307 putative CheW interface [polypeptide binding]; other site 693216005308 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 693216005309 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 693216005310 DNA-binding site [nucleotide binding]; DNA binding site 693216005311 RNA-binding motif; other site 693216005312 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 693216005313 iron-sulfur cluster [ion binding]; other site 693216005314 [2Fe-2S] cluster binding site [ion binding]; other site 693216005315 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 693216005316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693216005317 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693216005318 active site 693216005319 phosphorylation site [posttranslational modification] 693216005320 intermolecular recognition site; other site 693216005321 dimerization interface [polypeptide binding]; other site 693216005322 Protein of unknown function (DUF535); Region: DUF535; pfam04393 693216005323 Uncharacterized conserved protein [Function unknown]; Region: COG3189 693216005324 hypothetical protein; Validated; Region: PRK06186 693216005325 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 693216005326 conserved cys residue [active] 693216005327 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 693216005328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216005329 putative substrate translocation pore; other site 693216005330 Predicted membrane protein [Function unknown]; Region: COG2707 693216005331 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 693216005332 putative deacylase active site [active] 693216005333 General stress protein [General function prediction only]; Region: GsiB; COG3729 693216005334 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 693216005335 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 693216005336 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693216005337 hypothetical protein; Provisional; Region: PRK05325 693216005338 PrkA family serine protein kinase; Provisional; Region: PRK15455 693216005339 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693216005340 Walker A motif; other site 693216005341 ATP binding site [chemical binding]; other site 693216005342 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 693216005343 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 693216005344 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 693216005345 active site 693216005346 phosphate binding residues; other site 693216005347 catalytic residues [active] 693216005348 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 693216005349 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 693216005350 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 693216005351 methionine sulfoxide reductase B; Provisional; Region: PRK00222 693216005352 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 693216005353 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 693216005354 catalytic triad [active] 693216005355 metal binding site [ion binding]; metal-binding site 693216005356 conserved cis-peptide bond; other site 693216005357 cytoplasmic asparaginase I; Provisional; Region: ansA; PRK09461 693216005358 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 693216005359 active site 693216005360 homodimer interface [polypeptide binding]; other site 693216005361 protease 4; Provisional; Region: PRK10949 693216005362 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 693216005363 tandem repeat interface [polypeptide binding]; other site 693216005364 oligomer interface [polypeptide binding]; other site 693216005365 active site residues [active] 693216005366 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 693216005367 tandem repeat interface [polypeptide binding]; other site 693216005368 oligomer interface [polypeptide binding]; other site 693216005369 active site residues [active] 693216005370 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 693216005371 putative FMN binding site [chemical binding]; other site 693216005372 selenophosphate synthetase; Provisional; Region: PRK00943 693216005373 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 693216005374 dimerization interface [polypeptide binding]; other site 693216005375 putative ATP binding site [chemical binding]; other site 693216005376 DNA topoisomerase III; Provisional; Region: PRK07726 693216005377 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 693216005378 active site 693216005379 putative interdomain interaction site [polypeptide binding]; other site 693216005380 putative metal-binding site [ion binding]; other site 693216005381 putative nucleotide binding site [chemical binding]; other site 693216005382 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 693216005383 domain I; other site 693216005384 DNA binding groove [nucleotide binding] 693216005385 phosphate binding site [ion binding]; other site 693216005386 domain II; other site 693216005387 domain III; other site 693216005388 nucleotide binding site [chemical binding]; other site 693216005389 catalytic site [active] 693216005390 domain IV; other site 693216005391 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 693216005392 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 693216005393 active site 693216005394 8-oxo-dGMP binding site [chemical binding]; other site 693216005395 nudix motif; other site 693216005396 metal binding site [ion binding]; metal-binding site 693216005397 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 693216005398 putative catalytic site [active] 693216005399 putative phosphate binding site [ion binding]; other site 693216005400 active site 693216005401 metal binding site A [ion binding]; metal-binding site 693216005402 DNA binding site [nucleotide binding] 693216005403 putative AP binding site [nucleotide binding]; other site 693216005404 putative metal binding site B [ion binding]; other site 693216005405 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 693216005406 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693216005407 inhibitor-cofactor binding pocket; inhibition site 693216005408 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216005409 catalytic residue [active] 693216005410 arginine succinyltransferase; Provisional; Region: PRK10456 693216005411 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 693216005412 NAD(P) binding site [chemical binding]; other site 693216005413 catalytic residues [active] 693216005414 succinylarginine dihydrolase; Provisional; Region: PRK13281 693216005415 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 693216005416 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 693216005417 putative active site [active] 693216005418 Zn binding site [ion binding]; other site 693216005419 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 693216005420 dimer interface [polypeptide binding]; other site 693216005421 hypothetical protein; Provisional; Region: PRK11396 693216005422 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 693216005423 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 693216005424 GIY-YIG motif/motif A; other site 693216005425 active site 693216005426 catalytic site [active] 693216005427 putative DNA binding site [nucleotide binding]; other site 693216005428 metal binding site [ion binding]; metal-binding site 693216005429 aromatic amino acid exporter; Provisional; Region: PRK11689 693216005430 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 693216005431 homodimer interface [polypeptide binding]; other site 693216005432 NAD binding pocket [chemical binding]; other site 693216005433 ATP binding pocket [chemical binding]; other site 693216005434 Mg binding site [ion binding]; other site 693216005435 active-site loop [active] 693216005436 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 693216005437 hydroperoxidase II; Provisional; Region: katE; PRK11249 693216005438 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 693216005439 tetramer interface [polypeptide binding]; other site 693216005440 heme binding pocket [chemical binding]; other site 693216005441 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 693216005442 domain interactions; other site 693216005443 cell division modulator; Provisional; Region: PRK10113 693216005444 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 693216005445 inner membrane protein; Provisional; Region: PRK11648 693216005446 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 693216005447 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 693216005448 NADP binding site [chemical binding]; other site 693216005449 homodimer interface [polypeptide binding]; other site 693216005450 active site 693216005451 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 693216005452 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 693216005453 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693216005454 motif II; other site 693216005455 YniB-like protein; Region: YniB; pfam14002 693216005456 Fructosamine kinase; Region: Fructosamin_kin; pfam03881 693216005457 Phosphotransferase enzyme family; Region: APH; pfam01636 693216005458 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 693216005459 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 693216005460 putative substrate binding site [chemical binding]; other site 693216005461 putative ATP binding site [chemical binding]; other site 693216005462 Protein of unknown function, DUF481; Region: DUF481; cl01213 693216005463 proline/glycine betaine transporter; Provisional; Region: PRK10642 693216005464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216005465 putative substrate translocation pore; other site 693216005466 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 693216005467 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cl00178 693216005468 secondary substrate binding site; other site 693216005469 primary substrate binding site; other site 693216005470 inhibition loop; other site 693216005471 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 693216005472 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693216005473 Coenzyme A binding pocket [chemical binding]; other site 693216005474 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 693216005475 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 693216005476 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 693216005477 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 693216005478 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 693216005479 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 693216005480 active site 693216005481 dimer interface [polypeptide binding]; other site 693216005482 motif 1; other site 693216005483 motif 2; other site 693216005484 motif 3; other site 693216005485 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 693216005486 anticodon binding site; other site 693216005487 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 693216005488 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 693216005489 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 693216005490 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 693216005491 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 693216005492 23S rRNA binding site [nucleotide binding]; other site 693216005493 L21 binding site [polypeptide binding]; other site 693216005494 L13 binding site [polypeptide binding]; other site 693216005495 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 693216005496 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 693216005497 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 693216005498 dimer interface [polypeptide binding]; other site 693216005499 motif 1; other site 693216005500 active site 693216005501 motif 2; other site 693216005502 motif 3; other site 693216005503 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 693216005504 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 693216005505 putative tRNA-binding site [nucleotide binding]; other site 693216005506 B3/4 domain; Region: B3_4; pfam03483 693216005507 tRNA synthetase B5 domain; Region: B5; smart00874 693216005508 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 693216005509 dimer interface [polypeptide binding]; other site 693216005510 motif 1; other site 693216005511 motif 3; other site 693216005512 motif 2; other site 693216005513 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 693216005514 Alpha subunit of integration host factor (IHFA); Region: IHF_A; cd13835 693216005515 DNA binding site [nucleotide binding] 693216005516 dimer interface [polypeptide binding]; other site 693216005517 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 693216005518 ABC-ATPase subunit interface; other site 693216005519 dimer interface [polypeptide binding]; other site 693216005520 putative PBP binding regions; other site 693216005521 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 693216005522 catalytic residues [active] 693216005523 dimer interface [polypeptide binding]; other site 693216005524 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 693216005525 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 693216005526 Walker A/P-loop; other site 693216005527 ATP binding site [chemical binding]; other site 693216005528 Q-loop/lid; other site 693216005529 ABC transporter signature motif; other site 693216005530 Walker B; other site 693216005531 D-loop; other site 693216005532 H-loop/switch region; other site 693216005533 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 693216005534 NlpC/P60 family; Region: NLPC_P60; pfam00877 693216005535 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 693216005536 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 693216005537 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 693216005538 NAD binding site [chemical binding]; other site 693216005539 sugar binding site [chemical binding]; other site 693216005540 divalent metal binding site [ion binding]; other site 693216005541 tetramer (dimer of dimers) interface [polypeptide binding]; other site 693216005542 dimer interface [polypeptide binding]; other site 693216005543 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693216005544 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693216005545 DNA binding site [nucleotide binding] 693216005546 domain linker motif; other site 693216005547 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 693216005548 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 693216005549 hypothetical protein; Validated; Region: PRK00029 693216005550 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 693216005551 PEP synthetase regulatory protein; Provisional; Region: PRK05339 693216005552 phosphoenolpyruvate synthase; Validated; Region: PRK06464 693216005553 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 693216005554 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 693216005555 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 693216005556 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 693216005557 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216005558 putative substrate translocation pore; other site 693216005559 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 693216005560 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 693216005561 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 693216005562 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 693216005563 putative inner membrane protein; Provisional; Region: PRK10983 693216005564 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 693216005565 FAD binding domain; Region: FAD_binding_4; pfam01565 693216005566 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 693216005567 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 693216005568 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 693216005569 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 693216005570 CoenzymeA binding site [chemical binding]; other site 693216005571 subunit interaction site [polypeptide binding]; other site 693216005572 PHB binding site; other site 693216005573 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 693216005574 catalytic core [active] 693216005575 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 693216005576 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 693216005577 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 693216005578 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 693216005579 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 693216005580 Walker A/P-loop; other site 693216005581 ATP binding site [chemical binding]; other site 693216005582 Q-loop/lid; other site 693216005583 ABC transporter signature motif; other site 693216005584 Walker B; other site 693216005585 D-loop; other site 693216005586 H-loop/switch region; other site 693216005587 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 693216005588 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 693216005589 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 693216005590 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693216005591 catalytic residue [active] 693216005592 cysteine desufuration protein SufE; Provisional; Region: PRK09296 693216005593 L,D-transpeptidase; Provisional; Region: PRK10260 693216005594 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693216005595 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 693216005596 murein lipoprotein; Provisional; Region: PRK15396 693216005597 pyruvate kinase; Provisional; Region: PRK09206 693216005598 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 693216005599 active site 693216005600 domain interfaces; other site 693216005601 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 693216005602 hypothetical protein; Provisional; Region: PRK09945 693216005603 hypothetical protein; Provisional; Region: PRK09945 693216005604 hypothetical protein; Provisional; Region: PRK09945 693216005605 hypothetical protein; Provisional; Region: PRK09945 693216005606 hypothetical protein; Provisional; Region: PRK09945 693216005607 hypothetical protein; Provisional; Region: PRK09945 693216005608 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 693216005609 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 693216005610 Autotransporter beta-domain; Region: Autotransporter; smart00869 693216005611 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 693216005612 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 693216005613 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 693216005614 NAD(P) binding site [chemical binding]; other site 693216005615 catalytic residues [active] 693216005616 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 693216005617 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693216005618 non-specific DNA binding site [nucleotide binding]; other site 693216005619 salt bridge; other site 693216005620 sequence-specific DNA binding site [nucleotide binding]; other site 693216005621 Cupin domain; Region: Cupin_2; pfam07883 693216005622 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 693216005623 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 693216005624 catalytic triad [active] 693216005625 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 693216005626 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 693216005627 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 693216005628 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 693216005629 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 693216005630 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 693216005631 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 693216005632 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693216005633 Walker A motif; other site 693216005634 ATP binding site [chemical binding]; other site 693216005635 Walker B motif; other site 693216005636 arginine finger; other site 693216005637 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 693216005638 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 693216005639 dimerization interface [polypeptide binding]; other site 693216005640 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 693216005641 ATP binding site [chemical binding]; other site 693216005642 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 693216005643 hydrogenase assembly chaperone; Provisional; Region: PRK10409 693216005644 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 693216005645 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 693216005646 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 693216005647 Transcriptional repressor of hyc and hyp operons; Region: HycA_repressor; cl08095 693216005648 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 693216005649 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 693216005650 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 693216005651 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 693216005652 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 693216005653 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 693216005654 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 693216005655 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 693216005656 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 693216005657 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 693216005658 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 693216005659 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 693216005660 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 693216005661 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 693216005662 nickel binding site [ion binding]; other site 693216005663 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 693216005664 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 693216005665 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 693216005666 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 693216005667 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 693216005668 [4Fe-4S] binding site [ion binding]; other site 693216005669 molybdopterin cofactor binding site; other site 693216005670 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 693216005671 molybdopterin cofactor binding site; other site 693216005672 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 693216005673 Acylphosphatase; Region: Acylphosphatase; pfam00708 693216005674 HypF finger; Region: zf-HYPF; pfam07503 693216005675 HypF finger; Region: zf-HYPF; pfam07503 693216005676 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 693216005677 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 693216005678 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 693216005679 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 693216005680 molybdopterin cofactor binding site; other site 693216005681 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 693216005682 molybdopterin cofactor binding site; other site 693216005683 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693216005684 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216005685 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 693216005686 putative substrate binding pocket [chemical binding]; other site 693216005687 putative dimerization interface [polypeptide binding]; other site 693216005688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216005689 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693216005690 putative substrate translocation pore; other site 693216005691 Sigma-S stabilisation anti-adaptor protein; Region: Anti-adapt_IraP; pfam10796 693216005692 Uncharacterized conserved protein [Function unknown]; Region: COG3791 693216005693 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 693216005694 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 693216005695 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216005696 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693216005697 dimerization interface [polypeptide binding]; other site 693216005698 choline dehydrogenase; Validated; Region: PRK02106 693216005699 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 693216005700 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 693216005701 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 693216005702 tetrameric interface [polypeptide binding]; other site 693216005703 NAD binding site [chemical binding]; other site 693216005704 catalytic residues [active] 693216005705 transcriptional regulator BetI; Validated; Region: PRK00767 693216005706 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693216005707 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 693216005708 choline transport protein BetT; Provisional; Region: PRK09928 693216005709 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 693216005710 effector protein; Provisional; Region: PRK14052 693216005711 Protein of unknown function (DUF770); Region: DUF770; pfam05591 693216005712 Protein of unknown function (DUF877); Region: DUF877; cl05484 693216005713 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 693216005714 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 693216005715 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 693216005716 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693216005717 ligand binding site [chemical binding]; other site 693216005718 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 693216005719 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 693216005720 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693216005721 Walker A motif; other site 693216005722 ATP binding site [chemical binding]; other site 693216005723 Walker B motif; other site 693216005724 arginine finger; other site 693216005725 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693216005726 Walker A motif; other site 693216005727 ATP binding site [chemical binding]; other site 693216005728 Walker B motif; other site 693216005729 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 693216005730 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 693216005731 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 693216005732 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 693216005733 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 693216005734 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 693216005735 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 693216005736 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 693216005737 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 693216005738 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 693216005739 Bacteriophage peptidoglycan hydrolase; Region: Amidase_5; pfam05382 693216005740 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 693216005741 catalytic residue [active] 693216005742 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 693216005743 TIGR02594 family protein; Region: TIGR02594 693216005744 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 693216005745 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 693216005746 PAAR motif; Region: PAAR_motif; pfam05488 693216005747 Protein of unknown function (DUF3561); Region: DUF3561; cl08142 693216005748 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 693216005749 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 693216005750 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 693216005751 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 693216005752 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 693216005753 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 693216005754 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 693216005755 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 693216005756 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 693216005757 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 693216005758 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 693216005759 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 693216005760 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 693216005761 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, yeast PLDs, and similar proteins; Region: PLDc_vPLD1_2_yPLD_like_2; cd09141 693216005762 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 693216005763 putative active site [active] 693216005764 putative active site [active] 693216005765 catalytic site [active] 693216005766 catalytic site [active] 693216005767 multidrug efflux protein; Reviewed; Region: PRK01766 693216005768 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 693216005769 cation binding site [ion binding]; other site 693216005770 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 693216005771 Lumazine binding domain; Region: Lum_binding; pfam00677 693216005772 Lumazine binding domain; Region: Lum_binding; pfam00677 693216005773 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693216005774 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693216005775 DNA binding site [nucleotide binding] 693216005776 domain linker motif; other site 693216005777 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 693216005778 dimerization interface [polypeptide binding]; other site 693216005779 ligand binding site [chemical binding]; other site 693216005780 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 693216005781 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 693216005782 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 693216005783 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 693216005784 FtsJ-like methyltransferase; Region: FtsJ; cl17430 693216005785 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693216005786 S-adenosylmethionine binding site [chemical binding]; other site 693216005787 putative transporter; Provisional; Region: PRK11043 693216005788 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216005789 putative substrate translocation pore; other site 693216005790 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 693216005791 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216005792 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693216005793 dimerization interface [polypeptide binding]; other site 693216005794 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 693216005795 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693216005796 DNA binding site [nucleotide binding] 693216005797 domain linker motif; other site 693216005798 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 693216005799 dimerization interface [polypeptide binding]; other site 693216005800 ligand binding site [chemical binding]; other site 693216005801 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 693216005802 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216005803 putative substrate translocation pore; other site 693216005804 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 693216005805 NlpC/P60 family; Region: NLPC_P60; pfam00877 693216005806 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 693216005807 putative GSH binding site [chemical binding]; other site 693216005808 catalytic residues [active] 693216005809 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 693216005810 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 693216005811 dimer interface [polypeptide binding]; other site 693216005812 catalytic site [active] 693216005813 putative active site [active] 693216005814 putative substrate binding site [chemical binding]; other site 693216005815 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 693216005816 dimer interface [polypeptide binding]; other site 693216005817 active site 693216005818 metal binding site [ion binding]; metal-binding site 693216005819 glutathione binding site [chemical binding]; other site 693216005820 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 693216005821 FMN binding site [chemical binding]; other site 693216005822 active site 693216005823 substrate binding site [chemical binding]; other site 693216005824 catalytic residue [active] 693216005825 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693216005826 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693216005827 putative metal dependent hydrolase; Provisional; Region: PRK11598 693216005828 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 693216005829 Sulfatase; Region: Sulfatase; pfam00884 693216005830 Predicted Fe-S protein [General function prediction only]; Region: COG3313 693216005831 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693216005832 active site 693216005833 catalytic tetrad [active] 693216005834 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 693216005835 E-class dimer interface [polypeptide binding]; other site 693216005836 P-class dimer interface [polypeptide binding]; other site 693216005837 active site 693216005838 Cu2+ binding site [ion binding]; other site 693216005839 Zn2+ binding site [ion binding]; other site 693216005840 Fusaric acid resistance protein family; Region: FUSC; pfam04632 693216005841 Fusaric acid resistance protein-like; Region: FUSC_2; cl19401 693216005842 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 693216005843 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693216005844 HlyD family secretion protein; Region: HlyD_3; pfam13437 693216005845 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 693216005846 transcriptional regulator SlyA; Provisional; Region: PRK03573 693216005847 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693216005848 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 693216005849 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 693216005850 lysozyme inhibitor; Provisional; Region: PRK11372 693216005851 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 693216005852 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 693216005853 Pyridoxine 5'-phosphate oxidase C-terminal dimerization region; Region: PNPOx_C; pfam10590 693216005854 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 693216005855 Protein of unknown function (DUF2859); Region: DUF2859; cl12633 693216005856 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 693216005857 active site 693216005858 HIGH motif; other site 693216005859 dimer interface [polypeptide binding]; other site 693216005860 KMSKS motif; other site 693216005861 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693216005862 RNA binding surface [nucleotide binding]; other site 693216005863 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 693216005864 dimer interface [polypeptide binding]; other site 693216005865 pyridoxal binding site [chemical binding]; other site 693216005866 ATP binding site [chemical binding]; other site 693216005867 glutathionine S-transferase; Provisional; Region: PRK10542 693216005868 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 693216005869 C-terminal domain interface [polypeptide binding]; other site 693216005870 GSH binding site (G-site) [chemical binding]; other site 693216005871 dimer interface [polypeptide binding]; other site 693216005872 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 693216005873 dimer interface [polypeptide binding]; other site 693216005874 N-terminal domain interface [polypeptide binding]; other site 693216005875 substrate binding pocket (H-site) [chemical binding]; other site 693216005876 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 693216005877 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216005878 putative substrate translocation pore; other site 693216005879 endonuclease III; Provisional; Region: PRK10702 693216005880 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 693216005881 minor groove reading motif; other site 693216005882 helix-hairpin-helix signature motif; other site 693216005883 substrate binding pocket [chemical binding]; other site 693216005884 active site 693216005885 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 693216005886 electron transport complex RsxE subunit; Provisional; Region: PRK12405 693216005887 electron transport complex protein RnfG; Validated; Region: PRK01908 693216005888 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 693216005889 electron transport complex protein RnfC; Provisional; Region: PRK05035 693216005890 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 693216005891 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 693216005892 SLBB domain; Region: SLBB; pfam10531 693216005893 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 693216005894 ferredoxin; Provisional; Region: PRK08764 693216005895 Putative Fe-S cluster; Region: FeS; pfam04060 693216005896 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 693216005897 electron transport complex protein RsxA; Provisional; Region: PRK05151 693216005898 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 693216005899 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 693216005900 putative oxidoreductase; Provisional; Region: PRK11579 693216005901 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693216005902 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 693216005903 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 693216005904 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 693216005905 active site 693216005906 purine riboside binding site [chemical binding]; other site 693216005907 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 693216005908 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693216005909 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216005910 homodimer interface [polypeptide binding]; other site 693216005911 catalytic residue [active] 693216005912 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 693216005913 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 693216005914 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 693216005915 active site turn [active] 693216005916 phosphorylation site [posttranslational modification] 693216005917 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 693216005918 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693216005919 DNA binding site [nucleotide binding] 693216005920 domain linker motif; other site 693216005921 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 693216005922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 693216005923 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 693216005924 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 693216005925 fumarate hydratase; Provisional; Region: PRK15389 693216005926 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 693216005927 Fumarase C-terminus; Region: Fumerase_C; pfam05683 693216005928 fumarate hydratase; Reviewed; Region: fumC; PRK00485 693216005929 Class II fumarases; Region: Fumarase_classII; cd01362 693216005930 active site 693216005931 tetramer interface [polypeptide binding]; other site 693216005932 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 693216005933 sensor protein RstB; Provisional; Region: PRK10604 693216005934 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693216005935 dimerization interface [polypeptide binding]; other site 693216005936 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693216005937 dimer interface [polypeptide binding]; other site 693216005938 phosphorylation site [posttranslational modification] 693216005939 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693216005940 ATP binding site [chemical binding]; other site 693216005941 Mg2+ binding site [ion binding]; other site 693216005942 G-X-G motif; other site 693216005943 LysR family transcriptional regulator; Provisional; Region: PRK14997 693216005944 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216005945 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 693216005946 putative effector binding pocket; other site 693216005947 putative dimerization interface [polypeptide binding]; other site 693216005948 short chain dehydrogenase; Provisional; Region: PRK06500 693216005949 classical (c) SDRs; Region: SDR_c; cd05233 693216005950 NAD(P) binding site [chemical binding]; other site 693216005951 active site 693216005952 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 693216005953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693216005954 active site 693216005955 phosphorylation site [posttranslational modification] 693216005956 intermolecular recognition site; other site 693216005957 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693216005958 DNA binding site [nucleotide binding] 693216005959 dihydromonapterin reductase; Provisional; Region: PRK06483 693216005960 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 693216005961 NAD(P) binding site [chemical binding]; other site 693216005962 active site 693216005963 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 693216005964 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 693216005965 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 693216005966 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 693216005967 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 693216005968 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 693216005969 ligand binding site [chemical binding]; other site 693216005970 homodimer interface [polypeptide binding]; other site 693216005971 NAD(P) binding site [chemical binding]; other site 693216005972 trimer interface B [polypeptide binding]; other site 693216005973 trimer interface A [polypeptide binding]; other site 693216005974 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 693216005975 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 693216005976 universal stress protein UspE; Provisional; Region: PRK11175 693216005977 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 693216005978 Ligand Binding Site [chemical binding]; other site 693216005979 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 693216005980 Ligand Binding Site [chemical binding]; other site 693216005981 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 693216005982 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 693216005983 ligand binding site [chemical binding]; other site 693216005984 flexible hinge region; other site 693216005985 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 693216005986 putative switch regulator; other site 693216005987 non-specific DNA interactions [nucleotide binding]; other site 693216005988 DNA binding site [nucleotide binding] 693216005989 sequence specific DNA binding site [nucleotide binding]; other site 693216005990 putative cAMP binding site [chemical binding]; other site 693216005991 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 693216005992 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 693216005993 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 693216005994 DNA binding site [nucleotide binding] 693216005995 active site 693216005996 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 693216005997 Smr domain; Region: Smr; pfam01713 693216005998 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 693216005999 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693216006000 active site 693216006001 motif I; other site 693216006002 motif II; other site 693216006003 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 693216006004 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 693216006005 alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030 693216006006 Uncharacterized conserved protein [Function unknown]; Region: COG2128 693216006007 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 693216006008 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 693216006009 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693216006010 Walker A/P-loop; other site 693216006011 ATP binding site [chemical binding]; other site 693216006012 Q-loop/lid; other site 693216006013 ABC transporter signature motif; other site 693216006014 Walker B; other site 693216006015 D-loop; other site 693216006016 H-loop/switch region; other site 693216006017 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693216006018 Walker A/P-loop; other site 693216006019 ATP binding site [chemical binding]; other site 693216006020 Q-loop/lid; other site 693216006021 ABC transporter signature motif; other site 693216006022 Walker B; other site 693216006023 D-loop; other site 693216006024 H-loop/switch region; other site 693216006025 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693216006026 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 693216006027 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216006028 dimer interface [polypeptide binding]; other site 693216006029 conserved gate region; other site 693216006030 putative PBP binding loops; other site 693216006031 ABC-ATPase subunit interface; other site 693216006032 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 693216006033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216006034 dimer interface [polypeptide binding]; other site 693216006035 conserved gate region; other site 693216006036 putative PBP binding loops; other site 693216006037 ABC-ATPase subunit interface; other site 693216006038 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693216006039 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 693216006040 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 693216006041 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 693216006042 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 693216006043 putative symporter YagG; Provisional; Region: PRK09669; cl15392 693216006044 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 693216006045 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693216006046 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693216006047 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 693216006048 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 693216006049 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 693216006050 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 693216006051 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 693216006052 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693216006053 DNA-binding site [nucleotide binding]; DNA binding site 693216006054 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693216006055 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216006056 homodimer interface [polypeptide binding]; other site 693216006057 catalytic residue [active] 693216006058 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 693216006059 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 693216006060 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693216006061 Walker A/P-loop; other site 693216006062 ATP binding site [chemical binding]; other site 693216006063 Q-loop/lid; other site 693216006064 ABC transporter signature motif; other site 693216006065 Walker B; other site 693216006066 D-loop; other site 693216006067 H-loop/switch region; other site 693216006068 TOBE domain; Region: TOBE_2; pfam08402 693216006069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216006070 dimer interface [polypeptide binding]; other site 693216006071 conserved gate region; other site 693216006072 putative PBP binding loops; other site 693216006073 ABC-ATPase subunit interface; other site 693216006074 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 693216006075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216006076 dimer interface [polypeptide binding]; other site 693216006077 conserved gate region; other site 693216006078 putative PBP binding loops; other site 693216006079 ABC-ATPase subunit interface; other site 693216006080 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 693216006081 tetrameric interface [polypeptide binding]; other site 693216006082 NAD binding site [chemical binding]; other site 693216006083 catalytic residues [active] 693216006084 substrate binding site [chemical binding]; other site 693216006085 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693216006086 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 693216006087 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693216006088 Coenzyme A binding pocket [chemical binding]; other site 693216006089 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 693216006090 Cytochrome c; Region: Cytochrom_C; pfam00034 693216006091 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 693216006092 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 693216006093 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 693216006094 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 693216006095 putative [Fe4-S4] binding site [ion binding]; other site 693216006096 putative molybdopterin cofactor binding site [chemical binding]; other site 693216006097 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 693216006098 putative molybdopterin cofactor binding site; other site 693216006099 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 693216006100 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 693216006101 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 693216006102 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 693216006103 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 693216006104 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 693216006105 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 693216006106 SdiA-regulated; Region: SdiA-regulated; cl19046 693216006107 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 693216006108 ligand binding site [chemical binding]; other site 693216006109 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693216006110 dimerization interface [polypeptide binding]; other site 693216006111 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693216006112 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693216006113 dimer interface [polypeptide binding]; other site 693216006114 putative CheW interface [polypeptide binding]; other site 693216006115 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 693216006116 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 693216006117 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 693216006118 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 693216006119 acyl-CoA thioesterase; Provisional; Region: PRK10531 693216006120 Pectinesterase; Region: Pectinesterase; cl01911 693216006121 Putative bacterial virulence factor; Region: Virul_Fac; cl19867 693216006122 Virulence factor SrfB; Region: SrfB; pfam07520 693216006123 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693216006124 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 693216006125 peptide binding site [polypeptide binding]; other site 693216006126 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 693216006127 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 693216006128 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 693216006129 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 693216006130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 693216006131 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 693216006132 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693216006133 Coenzyme A binding pocket [chemical binding]; other site 693216006134 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 693216006135 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693216006136 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693216006137 non-specific DNA binding site [nucleotide binding]; other site 693216006138 salt bridge; other site 693216006139 sequence-specific DNA binding site [nucleotide binding]; other site 693216006140 Cupin domain; Region: Cupin_2; pfam07883 693216006141 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 693216006142 Prostaglandin dehydrogenases; Region: PGDH; cd05288 693216006143 NAD(P) binding site [chemical binding]; other site 693216006144 substrate binding site [chemical binding]; other site 693216006145 dimer interface [polypeptide binding]; other site 693216006146 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 693216006147 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693216006148 Walker A/P-loop; other site 693216006149 ATP binding site [chemical binding]; other site 693216006150 Q-loop/lid; other site 693216006151 ABC transporter signature motif; other site 693216006152 Walker B; other site 693216006153 D-loop; other site 693216006154 H-loop/switch region; other site 693216006155 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693216006156 Walker A/P-loop; other site 693216006157 ATP binding site [chemical binding]; other site 693216006158 Q-loop/lid; other site 693216006159 ABC transporter signature motif; other site 693216006160 Walker B; other site 693216006161 D-loop; other site 693216006162 H-loop/switch region; other site 693216006163 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693216006164 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; cl19124 693216006165 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 693216006166 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 693216006167 metal binding site [ion binding]; metal-binding site 693216006168 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 693216006169 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 693216006170 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216006171 dimer interface [polypeptide binding]; other site 693216006172 conserved gate region; other site 693216006173 putative PBP binding loops; other site 693216006174 ABC-ATPase subunit interface; other site 693216006175 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 693216006176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216006177 dimer interface [polypeptide binding]; other site 693216006178 conserved gate region; other site 693216006179 putative PBP binding loops; other site 693216006180 ABC-ATPase subunit interface; other site 693216006181 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 693216006182 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 693216006183 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 693216006184 DNA-binding site [nucleotide binding]; DNA binding site 693216006185 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 693216006186 FCD domain; Region: FCD; pfam07729 693216006187 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693216006188 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693216006189 dimerization interface [polypeptide binding]; other site 693216006190 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693216006191 dimer interface [polypeptide binding]; other site 693216006192 putative CheW interface [polypeptide binding]; other site 693216006193 short chain dehydrogenase; Provisional; Region: PRK07109 693216006194 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693216006195 NAD(P) binding site [chemical binding]; other site 693216006196 active site 693216006197 trehalose synthase; Region: treS_nterm; TIGR02456 693216006198 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 693216006199 active site 693216006200 catalytic site [active] 693216006201 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 693216006202 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693216006203 non-specific DNA binding site [nucleotide binding]; other site 693216006204 salt bridge; other site 693216006205 sequence-specific DNA binding site [nucleotide binding]; other site 693216006206 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 693216006207 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693216006208 N-terminal plug; other site 693216006209 ligand-binding site [chemical binding]; other site 693216006210 PQQ-like domain; Region: PQQ_2; pfam13360 693216006211 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 693216006212 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 693216006213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216006214 putative PBP binding loops; other site 693216006215 dimer interface [polypeptide binding]; other site 693216006216 ABC-ATPase subunit interface; other site 693216006217 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 693216006218 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 693216006219 Walker A/P-loop; other site 693216006220 ATP binding site [chemical binding]; other site 693216006221 Q-loop/lid; other site 693216006222 ABC transporter signature motif; other site 693216006223 Walker B; other site 693216006224 D-loop; other site 693216006225 H-loop/switch region; other site 693216006226 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 693216006227 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 693216006228 active site 693216006229 iron coordination sites [ion binding]; other site 693216006230 substrate binding pocket [chemical binding]; other site 693216006231 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 693216006232 NMT1-like family; Region: NMT1_2; pfam13379 693216006233 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 693216006234 L-asparagine permease; Provisional; Region: PRK15049 693216006235 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 693216006236 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 693216006237 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 693216006238 dimer interface [polypeptide binding]; other site 693216006239 FMN binding site [chemical binding]; other site 693216006240 4-oxalocrotonate tautomerase; Provisional; Region: PRK01271 693216006241 active site 1 [active] 693216006242 dimer interface [polypeptide binding]; other site 693216006243 hexamer interface [polypeptide binding]; other site 693216006244 active site 2 [active] 693216006245 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 693216006246 dimanganese center [ion binding]; other site 693216006247 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 693216006248 N-acetyltransferase; Region: Acetyltransf_2; cl00949 693216006249 Cupin; Region: Cupin_6; pfam12852 693216006250 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 693216006251 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693216006252 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693216006253 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 693216006254 Uncharacterized conserved protein [Function unknown]; Region: COG2128 693216006255 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 693216006256 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 693216006257 putative NAD(P) binding site [chemical binding]; other site 693216006258 putative substrate binding site [chemical binding]; other site 693216006259 catalytic Zn binding site [ion binding]; other site 693216006260 structural Zn binding site [ion binding]; other site 693216006261 dimer interface [polypeptide binding]; other site 693216006262 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 693216006263 classical (c) SDRs; Region: SDR_c; cd05233 693216006264 NAD(P) binding site [chemical binding]; other site 693216006265 active site 693216006266 TfoX N-terminal domain; Region: TfoX_N; pfam04993 693216006267 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 693216006268 Putative lysophospholipase; Region: Hydrolase_4; cl19140 693216006269 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 693216006270 Putative lysophospholipase; Region: Hydrolase_4; cl19140 693216006271 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 693216006272 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693216006273 NAD(P) binding site [chemical binding]; other site 693216006274 active site 693216006275 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 693216006276 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693216006277 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693216006278 UV-endonuclease UvdE; Region: UvdE; cl10036 693216006279 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216006280 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693216006281 putative substrate translocation pore; other site 693216006282 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 693216006283 EAL domain; Region: EAL; pfam00563 693216006284 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 693216006285 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 693216006286 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 693216006287 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 693216006288 NlpC/P60 family; Region: NLPC_P60; pfam00877 693216006289 sporulation sigma factor SigF; Validated; Region: PRK05572 693216006290 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693216006291 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216006292 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693216006293 putative effector binding pocket; other site 693216006294 dimerization interface [polypeptide binding]; other site 693216006295 Permeases of the major facilitator superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / Inorganic ion transport and metabolism / General function prediction only]; Region: ProP; COG0477 693216006296 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216006297 putative substrate translocation pore; other site 693216006298 GrpB protein; Region: GrpB; pfam04229 693216006299 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 693216006300 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693216006301 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693216006302 non-specific DNA binding site [nucleotide binding]; other site 693216006303 salt bridge; other site 693216006304 sequence-specific DNA binding site [nucleotide binding]; other site 693216006305 Cupin domain; Region: Cupin_2; pfam07883 693216006306 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693216006307 ATP binding site [chemical binding]; other site 693216006308 Mg2+ binding site [ion binding]; other site 693216006309 G-X-G motif; other site 693216006310 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 693216006311 anti sigma factor interaction site; other site 693216006312 regulatory phosphorylation site [posttranslational modification]; other site 693216006313 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693216006314 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693216006315 active site 693216006316 phosphorylation site [posttranslational modification] 693216006317 intermolecular recognition site; other site 693216006318 dimerization interface [polypeptide binding]; other site 693216006319 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 693216006320 OpgC protein; Region: OpgC_C; cl17858 693216006321 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 693216006322 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 693216006323 DXD motif; other site 693216006324 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 693216006325 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 693216006326 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 693216006327 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 693216006328 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 693216006329 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693216006330 putative active site [active] 693216006331 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 693216006332 heme pocket [chemical binding]; other site 693216006333 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693216006334 dimer interface [polypeptide binding]; other site 693216006335 phosphorylation site [posttranslational modification] 693216006336 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693216006337 ATP binding site [chemical binding]; other site 693216006338 Mg2+ binding site [ion binding]; other site 693216006339 G-X-G motif; other site 693216006340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693216006341 active site 693216006342 phosphorylation site [posttranslational modification] 693216006343 intermolecular recognition site; other site 693216006344 dimerization interface [polypeptide binding]; other site 693216006345 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693216006346 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693216006347 active site 693216006348 phosphorylation site [posttranslational modification] 693216006349 intermolecular recognition site; other site 693216006350 dimerization interface [polypeptide binding]; other site 693216006351 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 693216006352 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 693216006353 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 693216006354 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 693216006355 trehalase; Provisional; Region: treF; PRK13270 693216006356 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 693216006357 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 693216006358 active site 693216006359 oxyanion hole [active] 693216006360 catalytic triad [active] 693216006361 Autotransporter beta-domain; Region: Autotransporter; cl17461 693216006362 altronate oxidoreductase; Provisional; Region: PRK03643 693216006363 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 693216006364 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 693216006365 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 693216006366 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 693216006367 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693216006368 Coenzyme A binding pocket [chemical binding]; other site 693216006369 GAF domain; Region: GAF; pfam01590 693216006370 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693216006371 metal binding site [ion binding]; metal-binding site 693216006372 active site 693216006373 I-site; other site 693216006374 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 693216006375 MASE2 domain; Region: MASE2; pfam05230 693216006376 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693216006377 metal binding site [ion binding]; metal-binding site 693216006378 active site 693216006379 I-site; other site 693216006380 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693216006381 metal binding site [ion binding]; metal-binding site 693216006382 active site 693216006383 I-site; other site 693216006384 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 693216006385 glutaminase; Provisional; Region: PRK00971 693216006386 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 693216006387 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 693216006388 dimer interface [polypeptide binding]; other site 693216006389 ligand binding site [chemical binding]; other site 693216006390 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693216006391 dimerization interface [polypeptide binding]; other site 693216006392 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 693216006393 dimer interface [polypeptide binding]; other site 693216006394 putative CheW interface [polypeptide binding]; other site 693216006395 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 693216006396 NAD(P) binding site [chemical binding]; other site 693216006397 catalytic residues [active] 693216006398 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693216006399 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216006400 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 693216006401 putative dimerization interface [polypeptide binding]; other site 693216006402 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693216006403 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 693216006404 Coenzyme A binding pocket [chemical binding]; other site 693216006405 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 693216006406 tetramer (dimer of dimers) interface [polypeptide binding]; other site 693216006407 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 693216006408 NAD binding site [chemical binding]; other site 693216006409 dimer interface [polypeptide binding]; other site 693216006410 substrate binding site [chemical binding]; other site 693216006411 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 693216006412 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 693216006413 putative arabinose transporter; Provisional; Region: PRK03545 693216006414 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216006415 putative substrate translocation pore; other site 693216006416 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 693216006417 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693216006418 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 693216006419 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693216006420 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693216006421 hypothetical protein; Provisional; Region: PRK10106 693216006422 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 693216006423 EamA-like transporter family; Region: EamA; pfam00892 693216006424 EamA-like transporter family; Region: EamA; pfam00892 693216006425 putative transporter; Provisional; Region: PRK10054 693216006426 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216006427 putative substrate translocation pore; other site 693216006428 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 693216006429 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 693216006430 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 693216006431 Walker A/P-loop; other site 693216006432 ATP binding site [chemical binding]; other site 693216006433 Q-loop/lid; other site 693216006434 ABC transporter signature motif; other site 693216006435 Walker B; other site 693216006436 D-loop; other site 693216006437 H-loop/switch region; other site 693216006438 Uncharacterized ABC-type transport system, ATPase component [General function prediction only]; Region: COG4674 693216006439 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 693216006440 Walker A/P-loop; other site 693216006441 ATP binding site [chemical binding]; other site 693216006442 Q-loop/lid; other site 693216006443 ABC transporter signature motif; other site 693216006444 Walker B; other site 693216006445 D-loop; other site 693216006446 H-loop/switch region; other site 693216006447 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 693216006448 TM-ABC transporter signature motif; other site 693216006449 HEAT repeats; Region: HEAT_2; pfam13646 693216006450 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 693216006451 TM-ABC transporter signature motif; other site 693216006452 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 693216006453 putative ligand binding site [chemical binding]; other site 693216006454 Transcriptional regulators [Transcription]; Region: GntR; COG1802 693216006455 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693216006456 DNA-binding site [nucleotide binding]; DNA binding site 693216006457 FCD domain; Region: FCD; pfam07729 693216006458 urea carboxylase; Region: urea_carbox; TIGR02712 693216006459 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 693216006460 ATP-grasp domain; Region: ATP-grasp_4; cl17255 693216006461 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 693216006462 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 693216006463 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 693216006464 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 693216006465 carboxyltransferase (CT) interaction site; other site 693216006466 biotinylation site [posttranslational modification]; other site 693216006467 allophanate hydrolase; Provisional; Region: PRK08186 693216006468 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 693216006469 substrate binding site [chemical binding]; other site 693216006470 THF binding site; other site 693216006471 zinc-binding site [ion binding]; other site 693216006472 Protein of unknown function (DUF1264); Region: DUF1264; pfam06884 693216006473 General stress protein [General function prediction only]; Region: GsiB; COG3729 693216006474 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 693216006475 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 693216006476 transcriptional regulator MirA; Provisional; Region: PRK15043 693216006477 DNA binding residues [nucleotide binding] 693216006478 dimer interface [polypeptide binding]; other site 693216006479 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 693216006480 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 693216006481 active site 693216006482 Zn binding site [ion binding]; other site 693216006483 malonic semialdehyde reductase; Provisional; Region: PRK10538 693216006484 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 693216006485 putative NAD(P) binding site [chemical binding]; other site 693216006486 homodimer interface [polypeptide binding]; other site 693216006487 homotetramer interface [polypeptide binding]; other site 693216006488 active site 693216006489 Transcriptional regulators [Transcription]; Region: GntR; COG1802 693216006490 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693216006491 DNA-binding site [nucleotide binding]; DNA binding site 693216006492 FCD domain; Region: FCD; pfam07729 693216006493 YdfZ protein; Region: YdfZ; pfam14001 693216006494 D-mannonate oxidoreductase; Provisional; Region: PRK15037 693216006495 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 693216006496 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 693216006497 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216006498 metabolite-proton symporter; Region: 2A0106; TIGR00883 693216006499 putative substrate translocation pore; other site 693216006500 putative oxidoreductase; Provisional; Region: PRK10083 693216006501 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 693216006502 putative NAD(P) binding site [chemical binding]; other site 693216006503 catalytic Zn binding site [ion binding]; other site 693216006504 structural Zn binding site [ion binding]; other site 693216006505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216006506 D-galactonate transporter; Region: 2A0114; TIGR00893 693216006507 putative substrate translocation pore; other site 693216006508 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 693216006509 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 693216006510 putative active site pocket [active] 693216006511 putative metal binding site [ion binding]; other site 693216006512 hypothetical protein; Provisional; Region: PRK02237 693216006513 hypothetical protein; Provisional; Region: PRK13659 693216006514 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 693216006515 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693216006516 Coenzyme A binding pocket [chemical binding]; other site 693216006517 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 693216006518 lipoprotein; Reviewed; Region: PRK02939 693216006519 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 693216006520 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 693216006521 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 693216006522 putative [Fe4-S4] binding site [ion binding]; other site 693216006523 putative molybdopterin cofactor binding site [chemical binding]; other site 693216006524 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 693216006525 putative molybdopterin cofactor binding site; other site 693216006526 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 693216006527 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 693216006528 putative [Fe4-S4] binding site [ion binding]; other site 693216006529 putative molybdopterin cofactor binding site [chemical binding]; other site 693216006530 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 693216006531 putative molybdopterin cofactor binding site; other site 693216006532 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 693216006533 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 693216006534 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 693216006535 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 693216006536 GlpM protein; Region: GlpM; pfam06942 693216006537 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216006538 dimer interface [polypeptide binding]; other site 693216006539 conserved gate region; other site 693216006540 putative PBP binding loops; other site 693216006541 ABC-ATPase subunit interface; other site 693216006542 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 693216006543 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216006544 dimer interface [polypeptide binding]; other site 693216006545 conserved gate region; other site 693216006546 putative PBP binding loops; other site 693216006547 ABC-ATPase subunit interface; other site 693216006548 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 693216006549 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693216006550 Walker A/P-loop; other site 693216006551 ATP binding site [chemical binding]; other site 693216006552 Q-loop/lid; other site 693216006553 ABC transporter signature motif; other site 693216006554 Walker B; other site 693216006555 D-loop; other site 693216006556 H-loop/switch region; other site 693216006557 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 693216006558 putative dithiobiotin synthetase; Provisional; Region: PRK12374 693216006559 AAA domain; Region: AAA_26; pfam13500 693216006560 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 693216006561 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 693216006562 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 693216006563 nucleotide binding site [chemical binding]; other site 693216006564 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 693216006565 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 693216006566 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216006567 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 693216006568 dimerization interface [polypeptide binding]; other site 693216006569 substrate binding pocket [chemical binding]; other site 693216006570 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 693216006571 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216006572 putative substrate translocation pore; other site 693216006573 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 693216006574 active site 693216006575 Zn binding site [ion binding]; other site 693216006576 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 693216006577 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 693216006578 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 693216006579 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 693216006580 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 693216006581 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 693216006582 active site 693216006583 DNA binding site [nucleotide binding] 693216006584 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 693216006585 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 693216006586 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 693216006587 Catalytic site [active] 693216006588 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 693216006589 Collagenase; Region: DUF3656; pfam12392 693216006590 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 693216006591 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693216006592 non-specific DNA binding site [nucleotide binding]; other site 693216006593 salt bridge; other site 693216006594 sequence-specific DNA binding site [nucleotide binding]; other site 693216006595 Cupin domain; Region: Cupin_2; pfam07883 693216006596 benzoate transporter; Region: benE; TIGR00843 693216006597 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 693216006598 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 693216006599 tellurite resistance protein TehB; Provisional; Region: PRK11207 693216006600 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693216006601 S-adenosylmethionine binding site [chemical binding]; other site 693216006602 UDP-3-O-[3-hydroxymyristoyl]; Region: LpxD; COG1044 693216006603 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 693216006604 putative trimer interface [polypeptide binding]; other site 693216006605 putative CoA binding site [chemical binding]; other site 693216006606 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 693216006607 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 693216006608 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693216006609 Coenzyme A binding pocket [chemical binding]; other site 693216006610 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 693216006611 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 693216006612 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 693216006613 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 693216006614 substrate binding pocket [chemical binding]; other site 693216006615 catalytic triad [active] 693216006616 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 693216006617 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 693216006618 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216006619 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693216006620 dimerization interface [polypeptide binding]; other site 693216006621 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 693216006622 FMN binding site [chemical binding]; other site 693216006623 active site 693216006624 substrate binding site [chemical binding]; other site 693216006625 catalytic residue [active] 693216006626 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 693216006627 dimerization interface [polypeptide binding]; other site 693216006628 metal binding site [ion binding]; metal-binding site 693216006629 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 693216006630 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 693216006631 dimer interface [polypeptide binding]; other site 693216006632 ligand binding site [chemical binding]; other site 693216006633 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693216006634 dimerization interface [polypeptide binding]; other site 693216006635 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693216006636 dimer interface [polypeptide binding]; other site 693216006637 putative CheW interface [polypeptide binding]; other site 693216006638 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 693216006639 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 693216006640 substrate binding site [chemical binding]; other site 693216006641 catalytic Zn binding site [ion binding]; other site 693216006642 NAD binding site [chemical binding]; other site 693216006643 structural Zn binding site [ion binding]; other site 693216006644 dimer interface [polypeptide binding]; other site 693216006645 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 693216006646 putative metal binding site [ion binding]; other site 693216006647 putative homodimer interface [polypeptide binding]; other site 693216006648 putative homotetramer interface [polypeptide binding]; other site 693216006649 putative homodimer-homodimer interface [polypeptide binding]; other site 693216006650 putative allosteric switch controlling residues; other site 693216006651 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 693216006652 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 693216006653 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 693216006654 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216006655 metabolite-proton symporter; Region: 2A0106; TIGR00883 693216006656 putative substrate translocation pore; other site 693216006657 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 693216006658 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 693216006659 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 693216006660 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 693216006661 NAD binding site [chemical binding]; other site 693216006662 catalytic residues [active] 693216006663 substrate binding site [chemical binding]; other site 693216006664 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 693216006665 putative active site [active] 693216006666 FosA, a Fosfomycin resistance protein, catalyzes the addition of glutathione to the antibiotic fosfomycin, making it inactive; Region: FosA; cd07244 693216006667 dimer interface [polypeptide binding]; other site 693216006668 Mn binding site [ion binding]; other site 693216006669 K binding site [ion binding]; other site 693216006670 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693216006671 Coenzyme A binding pocket [chemical binding]; other site 693216006672 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 693216006673 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693216006674 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 693216006675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216006676 putative substrate translocation pore; other site 693216006677 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 693216006678 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 693216006679 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693216006680 HlyD family secretion protein; Region: HlyD_3; pfam13437 693216006681 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 693216006682 Outer membrane efflux protein; Region: OEP; pfam02321 693216006683 Outer membrane efflux protein; Region: OEP; pfam02321 693216006684 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 693216006685 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 693216006686 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693216006687 ATP binding site [chemical binding]; other site 693216006688 putative Mg++ binding site [ion binding]; other site 693216006689 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693216006690 nucleotide binding region [chemical binding]; other site 693216006691 ATP-binding site [chemical binding]; other site 693216006692 Helicase associated domain (HA2); Region: HA2; pfam04408 693216006693 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 693216006694 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 693216006695 azoreductase; Reviewed; Region: PRK00170 693216006696 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 693216006697 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 693216006698 hypothetical protein; Provisional; Region: PRK10695 693216006699 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 693216006700 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 693216006701 putative ligand binding site [chemical binding]; other site 693216006702 putative NAD binding site [chemical binding]; other site 693216006703 catalytic site [active] 693216006704 META domain; Region: META; cl01245 693216006705 Domain of unknown function (DUF333); Region: DUF333; cl19829 693216006706 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 693216006707 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 693216006708 dimer interface [polypeptide binding]; other site 693216006709 PYR/PP interface [polypeptide binding]; other site 693216006710 TPP binding site [chemical binding]; other site 693216006711 substrate binding site [chemical binding]; other site 693216006712 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 693216006713 Domain of unknown function; Region: EKR; pfam10371 693216006714 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 693216006715 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 693216006716 TPP-binding site [chemical binding]; other site 693216006717 dimer interface [polypeptide binding]; other site 693216006718 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 693216006719 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 693216006720 NAD binding site [chemical binding]; other site 693216006721 substrate binding site [chemical binding]; other site 693216006722 catalytic Zn binding site [ion binding]; other site 693216006723 tetramer interface [polypeptide binding]; other site 693216006724 structural Zn binding site [ion binding]; other site 693216006725 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 693216006726 NAD(P) binding site [chemical binding]; other site 693216006727 catalytic residues [active] 693216006728 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 693216006729 GAF domain; Region: GAF; pfam01590 693216006730 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693216006731 Walker A motif; other site 693216006732 ATP binding site [chemical binding]; other site 693216006733 Walker B motif; other site 693216006734 arginine finger; other site 693216006735 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 693216006736 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 693216006737 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl19057 693216006738 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 693216006739 oxidoreductase; Provisional; Region: PRK07985 693216006740 NAD binding site [chemical binding]; other site 693216006741 metal binding site [ion binding]; metal-binding site 693216006742 active site 693216006743 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 693216006744 putative catalytic site [active] 693216006745 putative metal binding site [ion binding]; other site 693216006746 putative phosphate binding site [ion binding]; other site 693216006747 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 693216006748 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 693216006749 Ligand Binding Site [chemical binding]; other site 693216006750 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 693216006751 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 693216006752 Cl binding site [ion binding]; other site 693216006753 oligomer interface [polypeptide binding]; other site 693216006754 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 693216006755 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 693216006756 GAF domain; Region: GAF; pfam01590 693216006757 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693216006758 nucleotidyl binding site; other site 693216006759 metal binding site [ion binding]; metal-binding site 693216006760 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693216006761 General stress protein [General function prediction only]; Region: GsiB; COG3729 693216006762 anti-adapter protein IraM; Provisional; Region: PRK09919 693216006763 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 693216006764 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 693216006765 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 693216006766 peptide binding site [polypeptide binding]; other site 693216006767 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 693216006768 putative active site [active] 693216006769 Zn binding site [ion binding]; other site 693216006770 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 693216006771 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 693216006772 active site 693216006773 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 693216006774 dimer interface [polypeptide binding]; other site 693216006775 catalytic triad [active] 693216006776 peroxidatic and resolving cysteines [active] 693216006777 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 693216006778 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 693216006779 putative aromatic amino acid binding site; other site 693216006780 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693216006781 putative active site [active] 693216006782 heme pocket [chemical binding]; other site 693216006783 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693216006784 Walker A motif; other site 693216006785 ATP binding site [chemical binding]; other site 693216006786 Walker B motif; other site 693216006787 arginine finger; other site 693216006788 hypothetical protein; Provisional; Region: PRK05415 693216006789 Predicted membrane protein [Function unknown]; Region: COG3768 693216006790 Predicted ATPase [General function prediction only]; Region: COG3106 693216006791 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693216006792 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693216006793 DNA binding site [nucleotide binding] 693216006794 domain linker motif; other site 693216006795 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 693216006796 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 693216006797 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 693216006798 Walker A/P-loop; other site 693216006799 ATP binding site [chemical binding]; other site 693216006800 Q-loop/lid; other site 693216006801 ABC transporter signature motif; other site 693216006802 Walker B; other site 693216006803 D-loop; other site 693216006804 H-loop/switch region; other site 693216006805 TOBE domain; Region: TOBE_2; pfam08402 693216006806 beta-phosphoglucomutase; Region: bPGM; TIGR01990 693216006807 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 693216006808 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693216006809 motif II; other site 693216006810 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 693216006811 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 693216006812 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 693216006813 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 693216006814 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 693216006815 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693216006816 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 693216006817 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 693216006818 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 693216006819 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 693216006820 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 693216006821 putative NAD(P) binding site [chemical binding]; other site 693216006822 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 693216006823 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216006824 dimer interface [polypeptide binding]; other site 693216006825 conserved gate region; other site 693216006826 putative PBP binding loops; other site 693216006827 ABC-ATPase subunit interface; other site 693216006828 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 693216006829 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216006830 dimer interface [polypeptide binding]; other site 693216006831 conserved gate region; other site 693216006832 putative PBP binding loops; other site 693216006833 ABC-ATPase subunit interface; other site 693216006834 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 693216006835 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 693216006836 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 693216006837 sucrose phosphorylase; Provisional; Region: PRK13840 693216006838 active site 693216006839 homodimer interface [polypeptide binding]; other site 693216006840 catalytic site [active] 693216006841 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 693216006842 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 693216006843 phage shock protein C; Region: phageshock_pspC; TIGR02978 693216006844 phage shock protein B; Provisional; Region: pspB; PRK09458 693216006845 phage shock protein PspA; Provisional; Region: PRK10698 693216006846 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 693216006847 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 693216006848 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693216006849 Walker A motif; other site 693216006850 ATP binding site [chemical binding]; other site 693216006851 Walker B motif; other site 693216006852 arginine finger; other site 693216006853 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 693216006854 antimicrobial peptide ABC transporter periplasmic binding protein SapA; Provisional; Region: PRK15109 693216006855 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 693216006856 peptide binding site [polypeptide binding]; other site 693216006857 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapB; COG4168 693216006858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216006859 dimer interface [polypeptide binding]; other site 693216006860 conserved gate region; other site 693216006861 putative PBP binding loops; other site 693216006862 ABC-ATPase subunit interface; other site 693216006863 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 693216006864 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 693216006865 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216006866 dimer interface [polypeptide binding]; other site 693216006867 conserved gate region; other site 693216006868 putative PBP binding loops; other site 693216006869 ABC-ATPase subunit interface; other site 693216006870 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 693216006871 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693216006872 Walker A/P-loop; other site 693216006873 ATP binding site [chemical binding]; other site 693216006874 Q-loop/lid; other site 693216006875 ABC transporter signature motif; other site 693216006876 Walker B; other site 693216006877 D-loop; other site 693216006878 H-loop/switch region; other site 693216006879 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693216006880 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 693216006881 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693216006882 Walker A/P-loop; other site 693216006883 ATP binding site [chemical binding]; other site 693216006884 Q-loop/lid; other site 693216006885 ABC transporter signature motif; other site 693216006886 Walker B; other site 693216006887 D-loop; other site 693216006888 H-loop/switch region; other site 693216006889 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693216006890 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 693216006891 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 693216006892 NAD binding site [chemical binding]; other site 693216006893 homotetramer interface [polypeptide binding]; other site 693216006894 homodimer interface [polypeptide binding]; other site 693216006895 substrate binding site [chemical binding]; other site 693216006896 active site 693216006897 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 693216006898 Uncharacterized conserved protein [Function unknown]; Region: COG2128 693216006899 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 693216006900 exoribonuclease II; Provisional; Region: PRK05054 693216006901 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 693216006902 RNB domain; Region: RNB; pfam00773 693216006903 S1 RNA binding domain; Region: S1; pfam00575 693216006904 RNase II stability modulator; Provisional; Region: PRK10060 693216006905 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693216006906 putative active site [active] 693216006907 heme pocket [chemical binding]; other site 693216006908 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693216006909 metal binding site [ion binding]; metal-binding site 693216006910 active site 693216006911 I-site; other site 693216006912 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693216006913 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 693216006914 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693216006915 substrate binding site [chemical binding]; other site 693216006916 oxyanion hole (OAH) forming residues; other site 693216006917 trimer interface [polypeptide binding]; other site 693216006918 hypothetical protein; Provisional; Region: PRK13658 693216006919 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 693216006920 active site 693216006921 intersubunit interactions; other site 693216006922 catalytic residue [active] 693216006923 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 693216006924 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 693216006925 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693216006926 FeS/SAM binding site; other site 693216006927 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 693216006928 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 693216006929 dimer interface [polypeptide binding]; other site 693216006930 active site 693216006931 glycine loop; other site 693216006932 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 693216006933 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 693216006934 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 693216006935 lipoprotein; Provisional; Region: PRK10540 693216006936 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 693216006937 putative rRNA binding site [nucleotide binding]; other site 693216006938 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 693216006939 active site 693216006940 dimer interface [polypeptide binding]; other site 693216006941 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 693216006942 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693216006943 TPR motif; other site 693216006944 binding surface 693216006945 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693216006946 binding surface 693216006947 TPR motif; other site 693216006948 Predicted membrane protein [Function unknown]; Region: COG3771 693216006949 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 693216006950 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 693216006951 active site 693216006952 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 693216006953 dimerization interface [polypeptide binding]; other site 693216006954 active site 693216006955 aconitate hydratase; Validated; Region: PRK09277 693216006956 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 693216006957 substrate binding site [chemical binding]; other site 693216006958 ligand binding site [chemical binding]; other site 693216006959 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 693216006960 substrate binding site [chemical binding]; other site 693216006961 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 693216006962 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216006963 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 693216006964 substrate binding site [chemical binding]; other site 693216006965 putative dimerization interface [polypeptide binding]; other site 693216006966 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 693216006967 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 693216006968 active site 693216006969 interdomain interaction site; other site 693216006970 putative metal-binding site [ion binding]; other site 693216006971 nucleotide binding site [chemical binding]; other site 693216006972 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 693216006973 domain I; other site 693216006974 DNA binding groove [nucleotide binding] 693216006975 phosphate binding site [ion binding]; other site 693216006976 domain II; other site 693216006977 domain III; other site 693216006978 nucleotide binding site [chemical binding]; other site 693216006979 catalytic site [active] 693216006980 domain IV; other site 693216006981 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 693216006982 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 693216006983 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 693216006984 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 693216006985 hypothetical protein; Provisional; Region: PRK11037 693216006986 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 693216006987 putative inner membrane peptidase; Provisional; Region: PRK11778 693216006988 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 693216006989 tandem repeat interface [polypeptide binding]; other site 693216006990 oligomer interface [polypeptide binding]; other site 693216006991 active site residues [active] 693216006992 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 693216006993 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 693216006994 NADP binding site [chemical binding]; other site 693216006995 homodimer interface [polypeptide binding]; other site 693216006996 active site 693216006997 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 693216006998 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 693216006999 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 693216007000 homodimer interface [polypeptide binding]; other site 693216007001 Walker A motif; other site 693216007002 ATP binding site [chemical binding]; other site 693216007003 hydroxycobalamin binding site [chemical binding]; other site 693216007004 Walker B motif; other site 693216007005 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 693216007006 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693216007007 RNA binding surface [nucleotide binding]; other site 693216007008 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 693216007009 probable active site [active] 693216007010 hypothetical protein; Provisional; Region: PRK11630 693216007011 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 693216007012 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 693216007013 active site 693216007014 anthranilate synthase component I; Provisional; Region: PRK13564 693216007015 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 693216007016 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 693216007017 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 693216007018 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 693216007019 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 693216007020 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 693216007021 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 693216007022 active site 693216007023 ribulose/triose binding site [chemical binding]; other site 693216007024 phosphate binding site [ion binding]; other site 693216007025 substrate (anthranilate) binding pocket [chemical binding]; other site 693216007026 product (indole) binding pocket [chemical binding]; other site 693216007027 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 693216007028 active site 693216007029 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 693216007030 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216007031 catalytic residue [active] 693216007032 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 693216007033 substrate binding site [chemical binding]; other site 693216007034 active site 693216007035 catalytic residues [active] 693216007036 heterodimer interface [polypeptide binding]; other site 693216007037 outer membrane protein W; Provisional; Region: PRK10959 693216007038 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 693216007039 hypothetical protein; Provisional; Region: PRK02868 693216007040 intracellular septation protein A; Reviewed; Region: PRK00259 693216007041 outer membrane receptor FepA; Provisional; Region: PRK13528 693216007042 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693216007043 N-terminal plug; other site 693216007044 ligand-binding site [chemical binding]; other site 693216007045 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 693216007046 transport protein TonB; Provisional; Region: PRK10819 693216007047 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544 693216007048 YciI-like protein; Reviewed; Region: PRK11370 693216007049 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 693216007050 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 693216007051 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 693216007052 putative active site [active] 693216007053 catalytic site [active] 693216007054 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 693216007055 putative active site [active] 693216007056 catalytic site [active] 693216007057 dsDNA-mimic protein; Reviewed; Region: PRK05094 693216007058 Ion transport protein; Region: Ion_trans; pfam00520 693216007059 Ion channel; Region: Ion_trans_2; pfam07885 693216007060 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 693216007061 Double zinc ribbon; Region: DZR; pfam12773 693216007062 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 693216007063 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693216007064 Walker A/P-loop; other site 693216007065 ATP binding site [chemical binding]; other site 693216007066 Q-loop/lid; other site 693216007067 ABC transporter signature motif; other site 693216007068 Walker B; other site 693216007069 D-loop; other site 693216007070 H-loop/switch region; other site 693216007071 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693216007072 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 693216007073 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693216007074 Walker A/P-loop; other site 693216007075 ATP binding site [chemical binding]; other site 693216007076 Q-loop/lid; other site 693216007077 ABC transporter signature motif; other site 693216007078 Walker B; other site 693216007079 D-loop; other site 693216007080 H-loop/switch region; other site 693216007081 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693216007082 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 693216007083 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 693216007084 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216007085 dimer interface [polypeptide binding]; other site 693216007086 conserved gate region; other site 693216007087 putative PBP binding loops; other site 693216007088 ABC-ATPase subunit interface; other site 693216007089 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 693216007090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216007091 dimer interface [polypeptide binding]; other site 693216007092 conserved gate region; other site 693216007093 putative PBP binding loops; other site 693216007094 ABC-ATPase subunit interface; other site 693216007095 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 693216007096 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 693216007097 peptide binding site [polypeptide binding]; other site 693216007098 hypothetical protein; Provisional; Region: PRK11111 693216007099 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 693216007100 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 693216007101 putative catalytic cysteine [active] 693216007102 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 693216007103 putative active site [active] 693216007104 metal binding site [ion binding]; metal-binding site 693216007105 thymidine kinase; Provisional; Region: PRK04296 693216007106 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 693216007107 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 693216007108 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 693216007109 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 693216007110 putative NAD(P) binding site [chemical binding]; other site 693216007111 active site 693216007112 putative substrate binding site [chemical binding]; other site 693216007113 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 693216007114 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 693216007115 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 693216007116 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 693216007117 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 693216007118 active site 693216007119 tetramer interface; other site 693216007120 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693216007121 active site 693216007122 response regulator of RpoS; Provisional; Region: PRK10693 693216007123 phosphorylation site [posttranslational modification] 693216007124 intermolecular recognition site; other site 693216007125 dimerization interface [polypeptide binding]; other site 693216007126 hypothetical protein; Provisional; Region: PRK01617 693216007127 SEC-C motif; Region: SEC-C; cl19389 693216007128 SEC-C motif; Region: SEC-C; cl19389 693216007129 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 693216007130 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 693216007131 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 693216007132 putative active site [active] 693216007133 putative substrate binding site [chemical binding]; other site 693216007134 putative cosubstrate binding site; other site 693216007135 catalytic site [active] 693216007136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216007137 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693216007138 putative substrate translocation pore; other site 693216007139 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693216007140 salt bridge; other site 693216007141 non-specific DNA binding site [nucleotide binding]; other site 693216007142 sequence-specific DNA binding site [nucleotide binding]; other site 693216007143 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 693216007144 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 693216007145 NADP binding site [chemical binding]; other site 693216007146 active site 693216007147 steroid binding site; other site 693216007148 Cupin; Region: Cupin_6; pfam12852 693216007149 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693216007150 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693216007151 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 693216007152 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 693216007153 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 693216007154 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 693216007155 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 693216007156 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 693216007157 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 693216007158 Respiratory nitrate reductase beta C-terminal; Region: Nitr_red_bet_C; pfam14711 693216007159 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 693216007160 Respiratory nitrate reductase alpha N-terminal; Region: Nitr_red_alph_N; pfam14710 693216007161 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 693216007162 [4Fe-4S] binding site [ion binding]; other site 693216007163 molybdopterin cofactor binding site [chemical binding]; other site 693216007164 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 693216007165 molybdopterin cofactor binding site; other site 693216007166 lysophospholipid transporter LplT; Provisional; Region: PRK11195; cl19150 693216007167 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 693216007168 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 693216007169 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 693216007170 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693216007171 dimerization interface [polypeptide binding]; other site 693216007172 Histidine kinase; Region: HisKA_3; pfam07730 693216007173 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693216007174 ATP binding site [chemical binding]; other site 693216007175 Mg2+ binding site [ion binding]; other site 693216007176 G-X-G motif; other site 693216007177 transcriptional regulator NarL; Provisional; Region: PRK10651 693216007178 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693216007179 active site 693216007180 phosphorylation site [posttranslational modification] 693216007181 intermolecular recognition site; other site 693216007182 dimerization interface [polypeptide binding]; other site 693216007183 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693216007184 DNA binding residues [nucleotide binding] 693216007185 dimerization interface [polypeptide binding]; other site 693216007186 putative invasin; Provisional; Region: PRK10177 693216007187 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 693216007188 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 693216007189 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 693216007190 [4Fe-4S] binding site [ion binding]; other site 693216007191 molybdopterin cofactor binding site; other site 693216007192 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 693216007193 molybdopterin cofactor binding site; other site 693216007194 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 693216007195 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 693216007196 nitrite reductase subunit NirD; Provisional; Region: PRK14989 693216007197 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 693216007198 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693216007199 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 693216007200 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 693216007201 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 693216007202 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 693216007203 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 693216007204 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 693216007205 Walker A/P-loop; other site 693216007206 ATP binding site [chemical binding]; other site 693216007207 Q-loop/lid; other site 693216007208 ABC transporter signature motif; other site 693216007209 Walker B; other site 693216007210 D-loop; other site 693216007211 H-loop/switch region; other site 693216007212 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 693216007213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216007214 dimer interface [polypeptide binding]; other site 693216007215 conserved gate region; other site 693216007216 putative PBP binding loops; other site 693216007217 ABC-ATPase subunit interface; other site 693216007218 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 693216007219 NMT1-like family; Region: NMT1_2; pfam13379 693216007220 Nitrate and nitrite sensing; Region: NIT; pfam08376 693216007221 ANTAR domain; Region: ANTAR; pfam03861 693216007222 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 693216007223 Cache domain; Region: Cache_1; pfam02743 693216007224 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693216007225 dimerization interface [polypeptide binding]; other site 693216007226 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693216007227 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693216007228 dimer interface [polypeptide binding]; other site 693216007229 putative CheW interface [polypeptide binding]; other site 693216007230 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 693216007231 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 693216007232 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 693216007233 putative active site pocket [active] 693216007234 dimerization interface [polypeptide binding]; other site 693216007235 putative catalytic residue [active] 693216007236 cation transport regulator; Reviewed; Region: chaB; PRK09582 693216007237 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 693216007238 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 693216007239 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 693216007240 hypothetical protein; Provisional; Region: PRK10941 693216007241 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 693216007242 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693216007243 binding surface 693216007244 TPR motif; other site 693216007245 Invasion gene expression up-regulator, SirB; Region: SirB; cl01184 693216007246 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 693216007247 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693216007248 S-adenosylmethionine binding site [chemical binding]; other site 693216007249 peptide chain release factor 1; Validated; Region: prfA; PRK00591 693216007250 This domain is found in peptide chain release factors; Region: PCRF; smart00937 693216007251 RF-1 domain; Region: RF-1; pfam00472 693216007252 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 693216007253 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 693216007254 tRNA; other site 693216007255 putative tRNA binding site [nucleotide binding]; other site 693216007256 putative NADP binding site [chemical binding]; other site 693216007257 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 693216007258 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 693216007259 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 693216007260 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 693216007261 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 693216007262 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 693216007263 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 693216007264 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693216007265 active site 693216007266 putative transporter; Provisional; Region: PRK11660 693216007267 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 693216007268 Sulfate transporter family; Region: Sulfate_transp; cl19250 693216007269 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 693216007270 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 693216007271 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 693216007272 DNA binding residues [nucleotide binding] 693216007273 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 693216007274 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 693216007275 hypothetical protein; Provisional; Region: PRK10692 693216007276 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 693216007277 putative active site [active] 693216007278 catalytic residue [active] 693216007279 GTP-binding protein YchF; Reviewed; Region: PRK09601 693216007280 YchF GTPase; Region: YchF; cd01900 693216007281 G1 box; other site 693216007282 GTP/Mg2+ binding site [chemical binding]; other site 693216007283 Switch I region; other site 693216007284 G2 box; other site 693216007285 Switch II region; other site 693216007286 G3 box; other site 693216007287 G4 box; other site 693216007288 G5 box; other site 693216007289 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 693216007290 hypothetical protein; Provisional; Region: PRK10396 693216007291 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 693216007292 SEC-C motif; Region: SEC-C; cl19389 693216007293 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 693216007294 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693216007295 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693216007296 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 693216007297 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 693216007298 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 693216007299 Uncharacterized conserved protein [Function unknown]; Region: COG2128 693216007300 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 693216007301 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 693216007302 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693216007303 DNA-binding site [nucleotide binding]; DNA binding site 693216007304 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693216007305 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216007306 homodimer interface [polypeptide binding]; other site 693216007307 catalytic residue [active] 693216007308 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216007309 dimer interface [polypeptide binding]; other site 693216007310 conserved gate region; other site 693216007311 putative PBP binding loops; other site 693216007312 ABC-ATPase subunit interface; other site 693216007313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216007314 dimer interface [polypeptide binding]; other site 693216007315 conserved gate region; other site 693216007316 putative PBP binding loops; other site 693216007317 ABC-ATPase subunit interface; other site 693216007318 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 693216007319 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 693216007320 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 693216007321 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693216007322 Walker A/P-loop; other site 693216007323 ATP binding site [chemical binding]; other site 693216007324 Q-loop/lid; other site 693216007325 ABC transporter signature motif; other site 693216007326 Walker B; other site 693216007327 D-loop; other site 693216007328 H-loop/switch region; other site 693216007329 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 693216007330 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693216007331 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693216007332 DNA binding site [nucleotide binding] 693216007333 domain linker motif; other site 693216007334 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 693216007335 putative dimerization interface [polypeptide binding]; other site 693216007336 putative ligand binding site [chemical binding]; other site 693216007337 trehalase; Provisional; Region: treA; PRK13271 693216007338 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 693216007339 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 693216007340 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693216007341 N-terminal plug; other site 693216007342 ligand-binding site [chemical binding]; other site 693216007343 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 693216007344 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 693216007345 Flagellar regulator YcgR; Region: YcgR; pfam07317 693216007346 PilZ domain; Region: PilZ; pfam07238 693216007347 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693216007348 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693216007349 catalytic residue [active] 693216007350 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 693216007351 dimer interface [polypeptide binding]; other site 693216007352 catalytic triad [active] 693216007353 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 693216007354 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693216007355 Coenzyme A binding pocket [chemical binding]; other site 693216007356 CHASE3 domain; Region: CHASE3; pfam05227 693216007357 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693216007358 HAMP domain; Region: HAMP; pfam00672 693216007359 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693216007360 dimer interface [polypeptide binding]; other site 693216007361 putative CheW interface [polypeptide binding]; other site 693216007362 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 693216007363 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693216007364 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 693216007365 active site 693216007366 catalytic tetrad [active] 693216007367 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693216007368 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216007369 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 693216007370 putative effector binding pocket; other site 693216007371 putative dimerization interface [polypeptide binding]; other site 693216007372 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 693216007373 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 693216007374 TrkA-C domain; Region: TrkA_C; pfam02080 693216007375 Transporter associated domain; Region: CorC_HlyC; smart01091 693216007376 alanine racemase; Reviewed; Region: dadX; PRK03646 693216007377 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 693216007378 active site 693216007379 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693216007380 substrate binding site [chemical binding]; other site 693216007381 catalytic residues [active] 693216007382 dimer interface [polypeptide binding]; other site 693216007383 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 693216007384 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 693216007385 SpoVR family protein; Provisional; Region: PRK11767 693216007386 fatty acid metabolism regulator; Provisional; Region: PRK04984 693216007387 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693216007388 DNA-binding site [nucleotide binding]; DNA binding site 693216007389 FadR C-terminal domain; Region: FadR_C; pfam07840 693216007390 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 693216007391 disulfide bond formation protein B; Provisional; Region: PRK01749 693216007392 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 693216007393 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 693216007394 Ligand binding site; other site 693216007395 Putative Catalytic site; other site 693216007396 DXD motif; other site 693216007397 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 693216007398 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 693216007399 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693216007400 Integrase core domain; Region: rve_3; pfam13683 693216007401 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693216007402 HTH-like domain; Region: HTH_21; pfam13276 693216007403 Integrase core domain; Region: rve; pfam00665 693216007404 Transposase; Region: HTH_Tnp_1; pfam01527 693216007405 hypothetical protein; Provisional; Region: PRK05170 693216007406 hypothetical protein; Provisional; Region: PRK10691 693216007407 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 693216007408 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 693216007409 septum formation inhibitor; Reviewed; Region: minC; PRK03511 693216007410 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 693216007411 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 693216007412 cell division inhibitor MinD; Provisional; Region: PRK10818 693216007413 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 693216007414 P-loop; other site 693216007415 ADP binding residues [chemical binding]; other site 693216007416 Switch I; other site 693216007417 Switch II; other site 693216007418 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 693216007419 ribonuclease D; Provisional; Region: PRK10829 693216007420 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 693216007421 catalytic site [active] 693216007422 putative active site [active] 693216007423 putative substrate binding site [chemical binding]; other site 693216007424 HRDC domain; Region: HRDC; pfam00570 693216007425 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 693216007426 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 693216007427 acyl-activating enzyme (AAE) consensus motif; other site 693216007428 putative AMP binding site [chemical binding]; other site 693216007429 putative active site [active] 693216007430 putative CoA binding site [chemical binding]; other site 693216007431 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 693216007432 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 693216007433 Glycoprotease family; Region: Peptidase_M22; pfam00814 693216007434 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 693216007435 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 693216007436 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 693216007437 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 693216007438 homotrimer interaction site [polypeptide binding]; other site 693216007439 putative active site [active] 693216007440 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 693216007441 putative di-iron ligands [ion binding]; other site 693216007442 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 693216007443 putative di-iron ligands [ion binding]; other site 693216007444 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 693216007445 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 693216007446 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 693216007447 active site 693216007448 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 693216007449 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 693216007450 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 693216007451 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693216007452 NAD(P) binding site [chemical binding]; other site 693216007453 active site 693216007454 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 693216007455 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 693216007456 dimer interface [polypeptide binding]; other site 693216007457 active site 693216007458 CoA binding pocket [chemical binding]; other site 693216007459 hypothetical protein; Provisional; Region: PRK05114 693216007460 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 693216007461 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 693216007462 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 693216007463 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 693216007464 putative active site [active] 693216007465 putative CoA binding site [chemical binding]; other site 693216007466 nudix motif; other site 693216007467 metal binding site [ion binding]; metal-binding site 693216007468 L-serine deaminase; Provisional; Region: PRK15023 693216007469 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 693216007470 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 693216007471 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 693216007472 phage resistance protein; Provisional; Region: PRK10551 693216007473 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693216007474 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 693216007475 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 693216007476 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 693216007477 Transporter associated domain; Region: CorC_HlyC; smart01091 693216007478 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 693216007479 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 693216007480 active pocket/dimerization site; other site 693216007481 active site 693216007482 phosphorylation site [posttranslational modification] 693216007483 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 693216007484 active site 693216007485 phosphorylation site [posttranslational modification] 693216007486 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 693216007487 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 693216007488 hypothetical protein; Provisional; Region: PRK02913 693216007489 hypothetical protein; Provisional; Region: PRK11469 693216007490 Domain of unknown function DUF; Region: DUF204; pfam02659 693216007491 Domain of unknown function DUF; Region: DUF204; pfam02659 693216007492 Methyltransferase domain; Region: Methyltransf_31; pfam13847 693216007493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693216007494 S-adenosylmethionine binding site [chemical binding]; other site 693216007495 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 693216007496 DNA-binding site [nucleotide binding]; DNA binding site 693216007497 RNA-binding motif; other site 693216007498 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 693216007499 YebO-like protein; Region: YebO; pfam13974 693216007500 PhoPQ regulatory protein; Provisional; Region: PRK10299 693216007501 YobH-like protein; Region: YobH; pfam13996 693216007502 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 693216007503 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693216007504 dimerization interface [polypeptide binding]; other site 693216007505 putative Zn2+ binding site [ion binding]; other site 693216007506 putative DNA binding site [nucleotide binding]; other site 693216007507 Bacterial transcriptional regulator; Region: IclR; pfam01614 693216007508 heat shock protein HtpX; Provisional; Region: PRK05457 693216007509 carboxy-terminal protease; Provisional; Region: PRK11186 693216007510 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 693216007511 protein binding site [polypeptide binding]; other site 693216007512 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 693216007513 Catalytic dyad [active] 693216007514 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 693216007515 ProP expression regulator; Provisional; Region: PRK04950 693216007516 putative RNA binding sites [nucleotide binding]; other site 693216007517 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 693216007518 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 693216007519 Paraquat-inducible protein A; Region: PqiA; pfam04403 693216007520 Paraquat-inducible protein A; Region: PqiA; pfam04403 693216007521 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 693216007522 mce related protein; Region: MCE; pfam02470 693216007523 mce related protein; Region: MCE; pfam02470 693216007524 mce related protein; Region: MCE; pfam02470 693216007525 mce related protein; Region: MCE; pfam02470 693216007526 mce related protein; Region: MCE; pfam02470 693216007527 mce related protein; Region: MCE; pfam02470 693216007528 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 693216007529 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693216007530 S-adenosylmethionine binding site [chemical binding]; other site 693216007531 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; cl19835 693216007532 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 693216007533 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 693216007534 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 693216007535 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 693216007536 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 693216007537 CopC domain; Region: CopC; cl01012 693216007538 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 693216007539 exodeoxyribonuclease X; Provisional; Region: PRK07983 693216007540 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 693216007541 active site 693216007542 catalytic site [active] 693216007543 substrate binding site [chemical binding]; other site 693216007544 protease 2; Provisional; Region: PRK10115 693216007545 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 693216007546 Protein of unknown function (DUF533); Region: DUF533; pfam04391 693216007547 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 693216007548 putative metal binding site [ion binding]; other site 693216007549 hypothetical protein; Provisional; Region: PRK13680 693216007550 YebG protein; Region: YebG; cl01217 693216007551 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 693216007552 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693216007553 ATP-grasp domain; Region: ATP-grasp; pfam02222 693216007554 Entner-Doudoroff aldolase; Region: eda; TIGR01182 693216007555 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 693216007556 active site 693216007557 intersubunit interface [polypeptide binding]; other site 693216007558 catalytic residue [active] 693216007559 phosphogluconate dehydratase; Validated; Region: PRK09054 693216007560 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 693216007561 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 693216007562 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 693216007563 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 693216007564 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 693216007565 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 693216007566 putative active site [active] 693216007567 pyruvate kinase; Provisional; Region: PRK05826 693216007568 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 693216007569 domain interfaces; other site 693216007570 active site 693216007571 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 693216007572 putative acyl-acceptor binding pocket; other site 693216007573 putative peptidase; Provisional; Region: PRK11649 693216007574 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 693216007575 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693216007576 Peptidase family M23; Region: Peptidase_M23; pfam01551 693216007577 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 693216007578 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 693216007579 metal binding site [ion binding]; metal-binding site 693216007580 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 693216007581 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 693216007582 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 693216007583 ABC-ATPase subunit interface; other site 693216007584 dimer interface [polypeptide binding]; other site 693216007585 putative PBP binding regions; other site 693216007586 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 693216007587 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693216007588 Walker A motif; other site 693216007589 ATP binding site [chemical binding]; other site 693216007590 Walker B motif; other site 693216007591 arginine finger; other site 693216007592 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 693216007593 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 693216007594 RuvA N terminal domain; Region: RuvA_N; pfam01330 693216007595 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 693216007596 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 693216007597 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 693216007598 active site 693216007599 putative DNA-binding cleft [nucleotide binding]; other site 693216007600 dimer interface [polypeptide binding]; other site 693216007601 hypothetical protein; Validated; Region: PRK00110 693216007602 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 693216007603 nudix motif; other site 693216007604 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 693216007605 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 693216007606 dimer interface [polypeptide binding]; other site 693216007607 anticodon binding site; other site 693216007608 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 693216007609 homodimer interface [polypeptide binding]; other site 693216007610 motif 1; other site 693216007611 active site 693216007612 motif 2; other site 693216007613 motif 3; other site 693216007614 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 693216007615 catalytic triad [active] 693216007616 conserved cis-peptide bond; other site 693216007617 hypothetical protein; Provisional; Region: PRK10302 693216007618 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 693216007619 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693216007620 S-adenosylmethionine binding site [chemical binding]; other site 693216007621 tRNA (mo5U34)-methyltransferase; Region: TIGR00452 693216007622 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693216007623 S-adenosylmethionine binding site [chemical binding]; other site 693216007624 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 693216007625 BON domain; Region: BON; pfam04972 693216007626 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693216007627 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 693216007628 HSP70 interaction site [polypeptide binding]; other site 693216007629 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 693216007630 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 693216007631 nucleotide binding site [chemical binding]; other site 693216007632 putative NEF/HSP70 interaction site [polypeptide binding]; other site 693216007633 SBD interface [polypeptide binding]; other site 693216007634 copper homeostasis protein CutC; Provisional; Region: PRK11572 693216007635 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 693216007636 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693216007637 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216007638 homodimer interface [polypeptide binding]; other site 693216007639 catalytic residue [active] 693216007640 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 693216007641 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 693216007642 NAD binding site [chemical binding]; other site 693216007643 catalytic Zn binding site [ion binding]; other site 693216007644 structural Zn binding site [ion binding]; other site 693216007645 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 693216007646 putative hydrophobic ligand binding site [chemical binding]; other site 693216007647 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 693216007648 putative metal binding site [ion binding]; other site 693216007649 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 693216007650 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 693216007651 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 693216007652 active site 693216007653 HIGH motif; other site 693216007654 KMSK motif region; other site 693216007655 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 693216007656 tRNA binding surface [nucleotide binding]; other site 693216007657 anticodon binding site; other site 693216007658 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 693216007659 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 693216007660 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 693216007661 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 693216007662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216007663 Flagellar protein FlhE; Region: FlhE; pfam06366 693216007664 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 693216007665 FlhB HrpN YscU SpaS Family; Region: Bac_export_2; cl19167 693216007666 chemotaxis regulator CheZ; Provisional; Region: PRK11166 693216007667 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693216007668 active site 693216007669 phosphorylation site [posttranslational modification] 693216007670 intermolecular recognition site; other site 693216007671 dimerization interface [polypeptide binding]; other site 693216007672 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 693216007673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693216007674 active site 693216007675 phosphorylation site [posttranslational modification] 693216007676 intermolecular recognition site; other site 693216007677 dimerization interface [polypeptide binding]; other site 693216007678 CheB methylesterase; Region: CheB_methylest; pfam01339 693216007679 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 693216007680 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 693216007681 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693216007682 S-adenosylmethionine binding site [chemical binding]; other site 693216007683 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 693216007684 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 693216007685 dimer interface [polypeptide binding]; other site 693216007686 ligand binding site [chemical binding]; other site 693216007687 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693216007688 dimerization interface [polypeptide binding]; other site 693216007689 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693216007690 dimer interface [polypeptide binding]; other site 693216007691 putative CheW interface [polypeptide binding]; other site 693216007692 Spore Coat Protein U domain; Region: SCPU; pfam05229 693216007693 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 693216007694 Outer membrane usher protein; Region: Usher; pfam00577 693216007695 PapC C-terminal domain; Region: PapC_C; pfam13953 693216007696 fimbrial chaperone protein StiB; Provisional; Region: PRK15299 693216007697 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 693216007698 Spore Coat Protein U domain; Region: SCPU; pfam05229 693216007699 Spore Coat Protein U domain; Region: SCPU; pfam05229 693216007700 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 693216007701 putative CheA interaction surface; other site 693216007702 chemotaxis protein CheA; Provisional; Region: PRK10547 693216007703 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 693216007704 putative binding surface; other site 693216007705 active site 693216007706 CheY binding; Region: CheY-binding; pfam09078 693216007707 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 693216007708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693216007709 ATP binding site [chemical binding]; other site 693216007710 Mg2+ binding site [ion binding]; other site 693216007711 G-X-G motif; other site 693216007712 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 693216007713 flagellar motor protein MotB; Validated; Region: motB; PRK09041 693216007714 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 693216007715 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693216007716 ligand binding site [chemical binding]; other site 693216007717 flagellar motor protein MotA; Validated; Region: PRK09110 693216007718 transcriptional activator FlhC; Provisional; Region: PRK12722 693216007719 transcriptional activator FlhD; Provisional; Region: PRK02909 693216007720 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 693216007721 Ligand Binding Site [chemical binding]; other site 693216007722 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 693216007723 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 693216007724 active site 693216007725 homotetramer interface [polypeptide binding]; other site 693216007726 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 693216007727 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693216007728 active site 693216007729 motif I; other site 693216007730 motif II; other site 693216007731 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693216007732 TM-ABC transporter signature motif; other site 693216007733 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 693216007734 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693216007735 Walker A/P-loop; other site 693216007736 ATP binding site [chemical binding]; other site 693216007737 Q-loop/lid; other site 693216007738 ABC transporter signature motif; other site 693216007739 Walker B; other site 693216007740 D-loop; other site 693216007741 H-loop/switch region; other site 693216007742 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693216007743 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 693216007744 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 693216007745 ligand binding site [chemical binding]; other site 693216007746 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 693216007747 DJ-1 family protein; Region: not_thiJ; TIGR01383 693216007748 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 693216007749 conserved cys residue [active] 693216007750 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 693216007751 Ferritin-like domain; Region: Ferritin; pfam00210 693216007752 ferroxidase diiron center [ion binding]; other site 693216007753 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 693216007754 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 693216007755 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 693216007756 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693216007757 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 693216007758 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 693216007759 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 693216007760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216007761 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693216007762 putative substrate translocation pore; other site 693216007763 hypothetical protein; Provisional; Region: PRK09273 693216007764 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 693216007765 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 693216007766 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693216007767 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693216007768 dimer interface [polypeptide binding]; other site 693216007769 putative CheW interface [polypeptide binding]; other site 693216007770 YecR-like lipoprotein; Region: YecR; pfam13992 693216007771 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 693216007772 Ferritin-like domain; Region: Ferritin; pfam00210 693216007773 ferroxidase diiron center [ion binding]; other site 693216007774 tyrosine transporter TyrP; Provisional; Region: PRK15132 693216007775 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 693216007776 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693216007777 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 693216007778 Coenzyme A binding pocket [chemical binding]; other site 693216007779 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 693216007780 DNA-binding site [nucleotide binding]; DNA binding site 693216007781 RNA-binding motif; other site 693216007782 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 693216007783 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 693216007784 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 693216007785 GIY-YIG motif/motif A; other site 693216007786 active site 693216007787 catalytic site [active] 693216007788 putative DNA binding site [nucleotide binding]; other site 693216007789 metal binding site [ion binding]; metal-binding site 693216007790 UvrB/uvrC motif; Region: UVR; pfam02151 693216007791 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 693216007792 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 693216007793 response regulator; Provisional; Region: PRK09483 693216007794 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693216007795 active site 693216007796 phosphorylation site [posttranslational modification] 693216007797 intermolecular recognition site; other site 693216007798 dimerization interface [polypeptide binding]; other site 693216007799 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693216007800 DNA binding residues [nucleotide binding] 693216007801 dimerization interface [polypeptide binding]; other site 693216007802 hypothetical protein; Provisional; Region: PRK10613 693216007803 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 693216007804 Autoinducer binding domain; Region: Autoind_bind; pfam03472 693216007805 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693216007806 DNA binding residues [nucleotide binding] 693216007807 dimerization interface [polypeptide binding]; other site 693216007808 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 693216007809 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 693216007810 Walker A/P-loop; other site 693216007811 ATP binding site [chemical binding]; other site 693216007812 Q-loop/lid; other site 693216007813 ABC transporter signature motif; other site 693216007814 Walker B; other site 693216007815 D-loop; other site 693216007816 H-loop/switch region; other site 693216007817 amino acid ABC transporter permease; Provisional; Region: PRK15100 693216007818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216007819 dimer interface [polypeptide binding]; other site 693216007820 conserved gate region; other site 693216007821 putative PBP binding loops; other site 693216007822 ABC-ATPase subunit interface; other site 693216007823 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 693216007824 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216007825 catalytic residue [active] 693216007826 cystine transporter subunit; Provisional; Region: PRK11260 693216007827 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693216007828 substrate binding pocket [chemical binding]; other site 693216007829 membrane-bound complex binding site; other site 693216007830 hinge residues; other site 693216007831 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 693216007832 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 693216007833 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693216007834 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 693216007835 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693216007836 DNA binding residues [nucleotide binding] 693216007837 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 693216007838 NAD(P) binding site [chemical binding]; other site 693216007839 catalytic residues [active] 693216007840 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 693216007841 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 693216007842 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 693216007843 acyl-activating enzyme (AAE) consensus motif; other site 693216007844 AMP binding site [chemical binding]; other site 693216007845 active site 693216007846 CoA binding site [chemical binding]; other site 693216007847 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 693216007848 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 693216007849 PYR/PP interface [polypeptide binding]; other site 693216007850 dimer interface [polypeptide binding]; other site 693216007851 TPP binding site [chemical binding]; other site 693216007852 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 693216007853 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 693216007854 TPP-binding site [chemical binding]; other site 693216007855 dimer interface [polypeptide binding]; other site 693216007856 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 693216007857 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693216007858 NAD(P) binding site [chemical binding]; other site 693216007859 active site 693216007860 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 693216007861 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693216007862 NAD(P) binding site [chemical binding]; other site 693216007863 active site 693216007864 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 693216007865 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 693216007866 putative trimer interface [polypeptide binding]; other site 693216007867 putative CoA binding site [chemical binding]; other site 693216007868 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 693216007869 inhibitor-cofactor binding pocket; inhibition site 693216007870 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216007871 catalytic residue [active] 693216007872 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693216007873 S-adenosylmethionine binding site [chemical binding]; other site 693216007874 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 693216007875 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693216007876 binding surface 693216007877 TPR motif; other site 693216007878 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 693216007879 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693216007880 binding surface 693216007881 TPR motif; other site 693216007882 Glycosyl transferases group 1; Region: Glycos_transf_1; cl19138 693216007883 flagellin; Validated; Region: PRK06819 693216007884 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 693216007885 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 693216007886 flagellar capping protein; Reviewed; Region: fliD; PRK08032 693216007887 Flagellar hook-associated protein 2 N-terminus; Region: FliD_N; pfam02465 693216007888 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 693216007889 flagellar protein FliS; Validated; Region: fliS; PRK05685 693216007890 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 693216007891 lipoprotein; Provisional; Region: PRK10397 693216007892 putative inner membrane protein; Provisional; Region: PRK11099 693216007893 Predicted transporter component [General function prediction only]; Region: COG2391 693216007894 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 693216007895 CPxP motif; other site 693216007896 hypothetical protein; Provisional; Region: PRK09951 693216007897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693216007898 S-adenosylmethionine binding site [chemical binding]; other site 693216007899 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 693216007900 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 693216007901 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 693216007902 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 693216007903 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 693216007904 flagellar motor switch protein FliG; Region: fliG; TIGR00207 693216007905 FliG N-terminal domain; Region: FliG_N; pfam14842 693216007906 FliG middle domain; Region: FliG_M; pfam14841 693216007907 FliG C-terminal domain; Region: FliG_C; pfam01706 693216007908 flagellar assembly protein H; Validated; Region: fliH; PRK05687 693216007909 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 693216007910 Flagellar assembly protein FliH; Region: FliH; pfam02108 693216007911 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 693216007912 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 693216007913 Walker A motif/ATP binding site; other site 693216007914 Walker B motif; other site 693216007915 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 693216007916 flagellar hook-length control protein; Provisional; Region: PRK10118 693216007917 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 693216007918 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 693216007919 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 693216007920 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 693216007921 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 693216007922 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 693216007923 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 693216007924 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 693216007925 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 693216007926 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 693216007927 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693216007928 DNA binding residues [nucleotide binding] 693216007929 dimerization interface [polypeptide binding]; other site 693216007930 hypothetical protein; Provisional; Region: PRK10708 693216007931 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 693216007932 mannosyl-3-phosphoglycerate phosphatase family; Region: HAD-SF-IIB-MPGP; TIGR01486 693216007933 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693216007934 active site 693216007935 motif I; other site 693216007936 motif II; other site 693216007937 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 693216007938 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693216007939 metal binding site [ion binding]; metal-binding site 693216007940 active site 693216007941 I-site; other site 693216007942 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 693216007943 hypothetical protein; Provisional; Region: PRK10062 693216007944 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 693216007945 EamA-like transporter family; Region: EamA; pfam00892 693216007946 EamA-like transporter family; Region: EamA; pfam00892 693216007947 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 693216007948 additional DNA contacts [nucleotide binding]; other site 693216007949 mismatch recognition site; other site 693216007950 active site 693216007951 zinc binding site [ion binding]; other site 693216007952 DNA intercalation site [nucleotide binding]; other site 693216007953 DNA cytosine methylase; Provisional; Region: PRK10458 693216007954 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 693216007955 cofactor binding site; other site 693216007956 DNA binding site [nucleotide binding] 693216007957 substrate interaction site [chemical binding]; other site 693216007958 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 693216007959 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693216007960 Zn2+ binding site [ion binding]; other site 693216007961 Mg2+ binding site [ion binding]; other site 693216007962 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 693216007963 trimer interface [polypeptide binding]; other site 693216007964 eyelet of channel; other site 693216007965 DinI-like family; Region: DinI; pfam06183 693216007966 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 693216007967 classical (c) SDRs; Region: SDR_c; cd05233 693216007968 NAD(P) binding site [chemical binding]; other site 693216007969 active site 693216007970 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 693216007971 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 693216007972 potential catalytic triad [active] 693216007973 conserved cys residue [active] 693216007974 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693216007975 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216007976 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693216007977 putative effector binding pocket; other site 693216007978 dimerization interface [polypeptide binding]; other site 693216007979 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693216007980 metal binding site [ion binding]; metal-binding site 693216007981 active site 693216007982 I-site; other site 693216007983 Uncharacterized protein family (UPF0257); Region: UPF0257; cl14672 693216007984 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 693216007985 shikimate transporter; Provisional; Region: PRK09952 693216007986 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216007987 putative substrate translocation pore; other site 693216007988 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 693216007989 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693216007990 dimerization interface [polypeptide binding]; other site 693216007991 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 693216007992 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216007993 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 693216007994 putative dimerization interface [polypeptide binding]; other site 693216007995 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 693216007996 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 693216007997 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 693216007998 Sensors of blue-light using FAD; Region: BLUF; smart01034 693216007999 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693216008000 AMP nucleosidase; Provisional; Region: PRK08292 693216008001 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 693216008002 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 693216008003 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 693216008004 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 693216008005 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 693216008006 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 693216008007 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 693216008008 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 693216008009 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 693216008010 MATE family multidrug exporter; Provisional; Region: PRK10189 693216008011 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 693216008012 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 693216008013 Uncharacterized alpha/beta hydrolase domain (DUF2235); Region: DUF2235; cl01480 693216008014 hypothetical protein; Provisional; Region: PRK05423 693216008015 Predicted membrane protein [Function unknown]; Region: COG1289 693216008016 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 693216008017 DNA gyrase inhibitor; Provisional; Region: PRK10016 693216008018 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 693216008019 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 693216008020 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 693216008021 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 693216008022 exonuclease I; Provisional; Region: sbcB; PRK11779 693216008023 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 693216008024 active site 693216008025 catalytic site [active] 693216008026 substrate binding site [chemical binding]; other site 693216008027 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 693216008028 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 693216008029 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 693216008030 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693216008031 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 693216008032 inhibitor-cofactor binding pocket; inhibition site 693216008033 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216008034 catalytic residue [active] 693216008035 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 693216008036 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 693216008037 catalytic triad [active] 693216008038 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 693216008039 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 693216008040 putative NAD(P) binding site [chemical binding]; other site 693216008041 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 693216008042 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 693216008043 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 693216008044 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 693216008045 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 693216008046 NAD binding site [chemical binding]; other site 693216008047 dimerization interface [polypeptide binding]; other site 693216008048 product binding site; other site 693216008049 substrate binding site [chemical binding]; other site 693216008050 zinc binding site [ion binding]; other site 693216008051 catalytic residues [active] 693216008052 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 693216008053 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693216008054 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216008055 homodimer interface [polypeptide binding]; other site 693216008056 catalytic residue [active] 693216008057 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 693216008058 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693216008059 active site 693216008060 motif I; other site 693216008061 motif II; other site 693216008062 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 693216008063 putative active site pocket [active] 693216008064 4-fold oligomerization interface [polypeptide binding]; other site 693216008065 metal binding residues [ion binding]; metal-binding site 693216008066 3-fold/trimer interface [polypeptide binding]; other site 693216008067 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 693216008068 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 693216008069 putative active site [active] 693216008070 oxyanion strand; other site 693216008071 catalytic triad [active] 693216008072 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 693216008073 catalytic residues [active] 693216008074 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 693216008075 substrate binding site [chemical binding]; other site 693216008076 glutamase interaction surface [polypeptide binding]; other site 693216008077 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 693216008078 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 693216008079 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 693216008080 metal binding site [ion binding]; metal-binding site 693216008081 chain length determinant protein WzzB; Provisional; Region: PRK15471 693216008082 Chain length determinant protein; Region: Wzz; pfam02706 693216008083 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 693216008084 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 693216008085 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 693216008086 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 693216008087 potential frameshift: common BLAST hit: gi|260856014|ref|YP_003229905.1| L-fucosamine transferase 693216008088 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 693216008089 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693216008090 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 693216008091 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 693216008092 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 693216008093 active site 693216008094 homodimer interface [polypeptide binding]; other site 693216008095 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 693216008096 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 693216008097 putative NAD(P) binding site [chemical binding]; other site 693216008098 active site 693216008099 putative substrate binding site [chemical binding]; other site 693216008100 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 693216008101 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 693216008102 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 693216008103 NAD(P) binding site [chemical binding]; other site 693216008104 homodimer interface [polypeptide binding]; other site 693216008105 substrate binding site [chemical binding]; other site 693216008106 active site 693216008107 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 693216008108 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693216008109 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 693216008110 EpsG family; Region: EpsG; pfam14897 693216008111 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 693216008112 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 693216008113 Polysaccharide biosynthesis C-terminal domain; Region: Polysacc_synt_C; pfam14667 693216008114 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693216008115 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 693216008116 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693216008117 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 693216008118 putative ADP-binding pocket [chemical binding]; other site 693216008119 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 693216008120 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 693216008121 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 693216008122 active site 693216008123 nucleotide binding site [chemical binding]; other site 693216008124 HIGH motif; other site 693216008125 KMSKS motif; other site 693216008126 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 693216008127 active site 693216008128 tetramer interface; other site 693216008129 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; cl19723 693216008130 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 693216008131 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 693216008132 putative ADP-binding pocket [chemical binding]; other site 693216008133 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 693216008134 colanic acid exporter; Provisional; Region: PRK10459 693216008135 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 693216008136 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 693216008137 CoA-binding domain; Region: CoA_binding_3; pfam13727 693216008138 Bacterial sugar transferase; Region: Bac_transf; pfam02397 693216008139 phosphomannomutase CpsG; Provisional; Region: PRK15414 693216008140 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 693216008141 active site 693216008142 substrate binding site [chemical binding]; other site 693216008143 metal binding site [ion binding]; metal-binding site 693216008144 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 693216008145 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 693216008146 Substrate binding site; other site 693216008147 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 693216008148 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 693216008149 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 693216008150 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 693216008151 active site 693216008152 GDP-Mannose binding site [chemical binding]; other site 693216008153 dimer interface [polypeptide binding]; other site 693216008154 modified nudix motif 693216008155 metal binding site [ion binding]; metal-binding site 693216008156 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 693216008157 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 693216008158 NADP binding site [chemical binding]; other site 693216008159 active site 693216008160 putative substrate binding site [chemical binding]; other site 693216008161 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 693216008162 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 693216008163 NADP-binding site; other site 693216008164 homotetramer interface [polypeptide binding]; other site 693216008165 substrate binding site [chemical binding]; other site 693216008166 homodimer interface [polypeptide binding]; other site 693216008167 active site 693216008168 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 693216008169 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 693216008170 putative trimer interface [polypeptide binding]; other site 693216008171 putative active site [active] 693216008172 putative substrate binding site [chemical binding]; other site 693216008173 putative CoA binding site [chemical binding]; other site 693216008174 colanic acid biosynthesis glycosyl transferase WcaE; Region: wcaE; TIGR04009 693216008175 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 693216008176 active site 693216008177 putative colanic acid biosynthesis protein; Provisional; Region: wcaD; cl08075 693216008178 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 693216008179 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 693216008180 putative acyl transferase; Provisional; Region: PRK10191 693216008181 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 693216008182 trimer interface [polypeptide binding]; other site 693216008183 active site 693216008184 substrate binding site [chemical binding]; other site 693216008185 CoA binding site [chemical binding]; other site 693216008186 colanic acid biosynthesis glycosyl transferase WcaA; Region: WcaA; TIGR04017 693216008187 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 693216008188 active site 693216008189 tyrosine kinase; Provisional; Region: PRK11519 693216008190 Chain length determinant protein; Region: Wzz; pfam02706 693216008191 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 693216008192 AAA domain; Region: AAA_31; pfam13614 693216008193 Low molecular weight phosphatase family; Region: LMWPc; cd00115 693216008194 active site 693216008195 polysaccharide export protein Wza; Provisional; Region: PRK15078 693216008196 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 693216008197 SLBB domain; Region: SLBB; pfam10531 693216008198 SLBB domain; Region: SLBB; pfam10531 693216008199 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 693216008200 FOG: CBS domain [General function prediction only]; Region: COG0517 693216008201 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 693216008202 Transporter associated domain; Region: CorC_HlyC; smart01091 693216008203 putative assembly protein; Provisional; Region: PRK10833 693216008204 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 693216008205 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 693216008206 trimer interface [polypeptide binding]; other site 693216008207 active site 693216008208 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 693216008209 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 693216008210 ATP-binding site [chemical binding]; other site 693216008211 Sugar specificity; other site 693216008212 Pyrimidine base specificity; other site 693216008213 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 693216008214 putative diguanylate cyclase; Provisional; Region: PRK09776 693216008215 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693216008216 putative active site [active] 693216008217 heme pocket [chemical binding]; other site 693216008218 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693216008219 putative active site [active] 693216008220 heme pocket [chemical binding]; other site 693216008221 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693216008222 putative active site [active] 693216008223 heme pocket [chemical binding]; other site 693216008224 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693216008225 metal binding site [ion binding]; metal-binding site 693216008226 active site 693216008227 I-site; other site 693216008228 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 693216008229 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 693216008230 AlkA N-terminal domain; Region: AlkA_N; pfam06029 693216008231 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 693216008232 minor groove reading motif; other site 693216008233 helix-hairpin-helix signature motif; other site 693216008234 substrate binding pocket [chemical binding]; other site 693216008235 active site 693216008236 putative chaperone; Provisional; Region: PRK11678 693216008237 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 693216008238 nucleotide binding site [chemical binding]; other site 693216008239 putative NEF/HSP70 interaction site [polypeptide binding]; other site 693216008240 SBD interface [polypeptide binding]; other site 693216008241 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693216008242 salt bridge; other site 693216008243 non-specific DNA binding site [nucleotide binding]; other site 693216008244 sequence-specific DNA binding site [nucleotide binding]; other site 693216008245 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 693216008246 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693216008247 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693216008248 HlyD family secretion protein; Region: HlyD_3; pfam13437 693216008249 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 693216008250 MMPL family; Region: MMPL; cl14618 693216008251 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 693216008252 MMPL family; Region: MMPL; cl14618 693216008253 putative transporter; Provisional; Region: PRK10504 693216008254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216008255 putative substrate translocation pore; other site 693216008256 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 693216008257 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693216008258 dimerization interface [polypeptide binding]; other site 693216008259 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693216008260 dimer interface [polypeptide binding]; other site 693216008261 phosphorylation site [posttranslational modification] 693216008262 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693216008263 ATP binding site [chemical binding]; other site 693216008264 Mg2+ binding site [ion binding]; other site 693216008265 G-X-G motif; other site 693216008266 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 693216008267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693216008268 active site 693216008269 phosphorylation site [posttranslational modification] 693216008270 intermolecular recognition site; other site 693216008271 dimerization interface [polypeptide binding]; other site 693216008272 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693216008273 DNA binding site [nucleotide binding] 693216008274 putative protease; Provisional; Region: PRK15452 693216008275 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 693216008276 lipid kinase; Reviewed; Region: PRK13054 693216008277 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 693216008278 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 693216008279 putative active site; other site 693216008280 catalytic residue [active] 693216008281 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 693216008282 dimer interface [polypeptide binding]; other site 693216008283 substrate binding site [chemical binding]; other site 693216008284 ATP binding site [chemical binding]; other site 693216008285 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 693216008286 substrate binding site [chemical binding]; other site 693216008287 multimerization interface [polypeptide binding]; other site 693216008288 ATP binding site [chemical binding]; other site 693216008289 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 693216008290 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 693216008291 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 693216008292 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693216008293 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693216008294 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 693216008295 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693216008296 dimerization interface [polypeptide binding]; other site 693216008297 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693216008298 dimer interface [polypeptide binding]; other site 693216008299 putative CheW interface [polypeptide binding]; other site 693216008300 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 693216008301 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693216008302 active site 693216008303 phosphorylation site [posttranslational modification] 693216008304 intermolecular recognition site; other site 693216008305 dimerization interface [polypeptide binding]; other site 693216008306 LytTr DNA-binding domain; Region: LytTR; pfam04397 693216008307 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 693216008308 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 693216008309 GAF domain; Region: GAF; pfam01590 693216008310 Histidine kinase; Region: His_kinase; pfam06580 693216008311 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693216008312 ATP binding site [chemical binding]; other site 693216008313 Mg2+ binding site [ion binding]; other site 693216008314 G-X-G motif; other site 693216008315 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 693216008316 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693216008317 Coenzyme A binding pocket [chemical binding]; other site 693216008318 antiporter inner membrane protein; Provisional; Region: PRK11670 693216008319 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 693216008320 Walker A motif; other site 693216008321 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 693216008322 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 693216008323 active site 693216008324 HIGH motif; other site 693216008325 KMSKS motif; other site 693216008326 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 693216008327 tRNA binding surface [nucleotide binding]; other site 693216008328 anticodon binding site; other site 693216008329 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 693216008330 dimer interface [polypeptide binding]; other site 693216008331 putative tRNA-binding site [nucleotide binding]; other site 693216008332 transcriptional regulator MirA; Provisional; Region: PRK15043 693216008333 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 693216008334 DNA binding residues [nucleotide binding] 693216008335 hypothetical protein; Provisional; Region: PRK13681 693216008336 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216008337 dimer interface [polypeptide binding]; other site 693216008338 conserved gate region; other site 693216008339 putative PBP binding loops; other site 693216008340 ABC-ATPase subunit interface; other site 693216008341 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 693216008342 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 693216008343 Walker A/P-loop; other site 693216008344 ATP binding site [chemical binding]; other site 693216008345 Q-loop/lid; other site 693216008346 ABC transporter signature motif; other site 693216008347 Walker B; other site 693216008348 D-loop; other site 693216008349 H-loop/switch region; other site 693216008350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216008351 dimer interface [polypeptide binding]; other site 693216008352 conserved gate region; other site 693216008353 putative PBP binding loops; other site 693216008354 ABC-ATPase subunit interface; other site 693216008355 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 693216008356 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 693216008357 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 693216008358 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 693216008359 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 693216008360 D-lactate dehydrogenase; Provisional; Region: PRK11183 693216008361 FAD binding domain; Region: FAD_binding_4; cl19922 693216008362 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 693216008363 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 693216008364 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693216008365 Coenzyme A binding pocket [chemical binding]; other site 693216008366 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 693216008367 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 693216008368 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 693216008369 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 693216008370 oxidoreductase; Provisional; Region: PRK12743 693216008371 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693216008372 NAD(P) binding site [chemical binding]; other site 693216008373 active site 693216008374 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 693216008375 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693216008376 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216008377 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 693216008378 putative substrate binding pocket [chemical binding]; other site 693216008379 putative dimerization interface [polypeptide binding]; other site 693216008380 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 693216008381 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 693216008382 FMN binding site [chemical binding]; other site 693216008383 active site 693216008384 catalytic residues [active] 693216008385 substrate binding site [chemical binding]; other site 693216008386 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693216008387 non-specific DNA binding site [nucleotide binding]; other site 693216008388 salt bridge; other site 693216008389 sequence-specific DNA binding site [nucleotide binding]; other site 693216008390 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 693216008391 hypothetical protein; Provisional; Region: PRK01821 693216008392 hypothetical protein; Provisional; Region: PRK10711 693216008393 cytidine deaminase; Provisional; Region: PRK09027 693216008394 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 693216008395 active site 693216008396 catalytic motif [active] 693216008397 Zn binding site [ion binding]; other site 693216008398 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 693216008399 active site 693216008400 catalytic motif [active] 693216008401 Zn binding site [ion binding]; other site 693216008402 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 693216008403 putative active site [active] 693216008404 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693216008405 TM-ABC transporter signature motif; other site 693216008406 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693216008407 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 693216008408 Walker A/P-loop; other site 693216008409 ATP binding site [chemical binding]; other site 693216008410 Q-loop/lid; other site 693216008411 ABC transporter signature motif; other site 693216008412 Walker B; other site 693216008413 D-loop; other site 693216008414 H-loop/switch region; other site 693216008415 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693216008416 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 693216008417 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 693216008418 ligand binding site [chemical binding]; other site 693216008419 calcium binding site [ion binding]; other site 693216008420 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 693216008421 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693216008422 DNA binding site [nucleotide binding] 693216008423 domain linker motif; other site 693216008424 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 693216008425 dimerization interface (closed form) [polypeptide binding]; other site 693216008426 ligand binding site [chemical binding]; other site 693216008427 Predicted membrane protein [Function unknown]; Region: COG2311 693216008428 hypothetical protein; Provisional; Region: PRK10835 693216008429 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 693216008430 active site 693216008431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216008432 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693216008433 putative substrate translocation pore; other site 693216008434 Predicted esterase [General function prediction only]; Region: COG0627 693216008435 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 693216008436 lysine transporter; Provisional; Region: PRK10836 693216008437 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 693216008438 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 693216008439 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216008440 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 693216008441 putative dimerization interface [polypeptide binding]; other site 693216008442 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 693216008443 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 693216008444 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 693216008445 AP (apurinic/apyrimidinic) site pocket; other site 693216008446 DNA interaction; other site 693216008447 Metal-binding active site; metal-binding site 693216008448 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 693216008449 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 693216008450 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 693216008451 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 693216008452 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 693216008453 active site 693216008454 P-loop; other site 693216008455 phosphorylation site [posttranslational modification] 693216008456 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 693216008457 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 693216008458 putative substrate binding site [chemical binding]; other site 693216008459 putative ATP binding site [chemical binding]; other site 693216008460 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 693216008461 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 693216008462 active site 693216008463 phosphorylation site [posttranslational modification] 693216008464 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 693216008465 dimerization domain swap beta strand [polypeptide binding]; other site 693216008466 regulatory protein interface [polypeptide binding]; other site 693216008467 active site 693216008468 regulatory phosphorylation site [posttranslational modification]; other site 693216008469 sugar efflux transporter B; Provisional; Region: PRK15011 693216008470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216008471 putative substrate translocation pore; other site 693216008472 Putative zinc- or iron-chelating domain; Region: CxxCxxCC; cl00497 693216008473 elongation factor P; Provisional; Region: PRK04542 693216008474 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 693216008475 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 693216008476 RNA binding site [nucleotide binding]; other site 693216008477 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 693216008478 RNA binding site [nucleotide binding]; other site 693216008479 mannonate dehydratase; Provisional; Region: PRK03906 693216008480 mannonate dehydratase; Region: uxuA; TIGR00695 693216008481 D-mannonate oxidoreductase; Provisional; Region: PRK15037 693216008482 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 693216008483 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 693216008484 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 693216008485 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 693216008486 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 693216008487 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 693216008488 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 693216008489 active site 693216008490 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 693216008491 NlpC/P60 family; Region: NLPC_P60; pfam00877 693216008492 phage resistance protein; Provisional; Region: PRK10551 693216008493 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 693216008494 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693216008495 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 693216008496 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 693216008497 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 693216008498 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216008499 dimer interface [polypeptide binding]; other site 693216008500 conserved gate region; other site 693216008501 putative PBP binding loops; other site 693216008502 ABC-ATPase subunit interface; other site 693216008503 microcin C ABC transporter permease; Provisional; Region: PRK15021 693216008504 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 693216008505 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216008506 dimer interface [polypeptide binding]; other site 693216008507 conserved gate region; other site 693216008508 putative PBP binding loops; other site 693216008509 ABC-ATPase subunit interface; other site 693216008510 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 693216008511 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693216008512 Walker A/P-loop; other site 693216008513 ATP binding site [chemical binding]; other site 693216008514 Q-loop/lid; other site 693216008515 ABC transporter signature motif; other site 693216008516 Walker B; other site 693216008517 D-loop; other site 693216008518 H-loop/switch region; other site 693216008519 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693216008520 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693216008521 Walker A/P-loop; other site 693216008522 ATP binding site [chemical binding]; other site 693216008523 Q-loop/lid; other site 693216008524 ABC transporter signature motif; other site 693216008525 Walker B; other site 693216008526 D-loop; other site 693216008527 H-loop/switch region; other site 693216008528 hypothetical protein; Provisional; Region: PRK11835 693216008529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216008530 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 693216008531 putative substrate translocation pore; other site 693216008532 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 693216008533 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693216008534 RNA binding surface [nucleotide binding]; other site 693216008535 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 693216008536 active site 693216008537 uracil binding [chemical binding]; other site 693216008538 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 693216008539 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693216008540 ATP binding site [chemical binding]; other site 693216008541 putative Mg++ binding site [ion binding]; other site 693216008542 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693216008543 nucleotide binding region [chemical binding]; other site 693216008544 ATP-binding site [chemical binding]; other site 693216008545 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 693216008546 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 693216008547 5S rRNA interface [nucleotide binding]; other site 693216008548 CTC domain interface [polypeptide binding]; other site 693216008549 L16 interface [polypeptide binding]; other site 693216008550 nucleoid-associated protein NdpA; Validated; Region: PRK00378 693216008551 hypothetical protein; Provisional; Region: PRK13689 693216008552 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 693216008553 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 693216008554 Sulfatase; Region: Sulfatase; cl19157 693216008555 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 693216008556 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693216008557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693216008558 active site 693216008559 phosphorylation site [posttranslational modification] 693216008560 intermolecular recognition site; other site 693216008561 dimerization interface [polypeptide binding]; other site 693216008562 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693216008563 DNA binding site [nucleotide binding] 693216008564 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693216008565 HAMP domain; Region: HAMP; pfam00672 693216008566 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693216008567 dimer interface [polypeptide binding]; other site 693216008568 phosphorylation site [posttranslational modification] 693216008569 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693216008570 ATP binding site [chemical binding]; other site 693216008571 Mg2+ binding site [ion binding]; other site 693216008572 G-X-G motif; other site 693216008573 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 693216008574 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 693216008575 Iron-containing redox enzyme; Region: Haem_oxygenas_2; pfam14518 693216008576 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 693216008577 EamA-like transporter family; Region: EamA; pfam00892 693216008578 EamA-like transporter family; Region: EamA; pfam00892 693216008579 KTSC domain; Region: KTSC; pfam13619 693216008580 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 693216008581 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 693216008582 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693216008583 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 693216008584 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 693216008585 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 693216008586 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 693216008587 iron binding site [ion binding]; other site 693216008588 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 693216008589 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 693216008590 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693216008591 Walker A motif; other site 693216008592 ATP binding site [chemical binding]; other site 693216008593 Walker B motif; other site 693216008594 arginine finger; other site 693216008595 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 693216008596 high affinity sulphate transporter 1; Region: sulP; TIGR00815 693216008597 Sulfate transporter family; Region: Sulfate_transp; pfam00916 693216008598 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 693216008599 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 693216008600 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693216008601 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 693216008602 Walker A/P-loop; other site 693216008603 ATP binding site [chemical binding]; other site 693216008604 Q-loop/lid; other site 693216008605 ABC transporter signature motif; other site 693216008606 Walker B; other site 693216008607 D-loop; other site 693216008608 H-loop/switch region; other site 693216008609 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 693216008610 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 693216008611 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 693216008612 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693216008613 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 693216008614 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 693216008615 DNA binding site [nucleotide binding] 693216008616 active site 693216008617 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 693216008618 outer membrane porin protein C; Provisional; Region: PRK10554 693216008619 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 693216008620 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693216008621 ATP binding site [chemical binding]; other site 693216008622 Mg2+ binding site [ion binding]; other site 693216008623 G-X-G motif; other site 693216008624 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 693216008625 putative binding surface; other site 693216008626 active site 693216008627 transcriptional regulator RcsB; Provisional; Region: PRK10840 693216008628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693216008629 active site 693216008630 phosphorylation site [posttranslational modification] 693216008631 intermolecular recognition site; other site 693216008632 dimerization interface [polypeptide binding]; other site 693216008633 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693216008634 DNA binding residues [nucleotide binding] 693216008635 dimerization interface [polypeptide binding]; other site 693216008636 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 693216008637 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693216008638 dimer interface [polypeptide binding]; other site 693216008639 phosphorylation site [posttranslational modification] 693216008640 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693216008641 ATP binding site [chemical binding]; other site 693216008642 Mg2+ binding site [ion binding]; other site 693216008643 G-X-G motif; other site 693216008644 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 693216008645 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693216008646 active site 693216008647 phosphorylation site [posttranslational modification] 693216008648 intermolecular recognition site; other site 693216008649 dimerization interface [polypeptide binding]; other site 693216008650 DNA gyrase subunit A; Validated; Region: PRK05560 693216008651 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 693216008652 CAP-like domain; other site 693216008653 active site 693216008654 primary dimer interface [polypeptide binding]; other site 693216008655 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693216008656 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693216008657 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693216008658 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693216008659 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693216008660 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693216008661 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 693216008662 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693216008663 S-adenosylmethionine binding site [chemical binding]; other site 693216008664 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 693216008665 ATP cone domain; Region: ATP-cone; pfam03477 693216008666 Class I ribonucleotide reductase; Region: RNR_I; cd01679 693216008667 active site 693216008668 dimer interface [polypeptide binding]; other site 693216008669 catalytic residues [active] 693216008670 effector binding site; other site 693216008671 R2 peptide binding site; other site 693216008672 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 693216008673 dimer interface [polypeptide binding]; other site 693216008674 putative radical transfer pathway; other site 693216008675 diiron center [ion binding]; other site 693216008676 tyrosyl radical; other site 693216008677 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693216008678 catalytic loop [active] 693216008679 iron binding site [ion binding]; other site 693216008680 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 693216008681 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 693216008682 active site 693216008683 catalytic site [active] 693216008684 metal binding site [ion binding]; metal-binding site 693216008685 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 693216008686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216008687 putative substrate translocation pore; other site 693216008688 hypothetical protein; Provisional; Region: PRK03673 693216008689 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 693216008690 putative MPT binding site; other site 693216008691 Competence-damaged protein; Region: CinA; cl00666 693216008692 YfaZ precursor; Region: YfaZ; pfam07437 693216008693 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 693216008694 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693216008695 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693216008696 dimerization interface [polypeptide binding]; other site 693216008697 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693216008698 dimer interface [polypeptide binding]; other site 693216008699 phosphorylation site [posttranslational modification] 693216008700 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693216008701 ATP binding site [chemical binding]; other site 693216008702 Mg2+ binding site [ion binding]; other site 693216008703 G-X-G motif; other site 693216008704 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 693216008705 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693216008706 active site 693216008707 phosphorylation site [posttranslational modification] 693216008708 intermolecular recognition site; other site 693216008709 dimerization interface [polypeptide binding]; other site 693216008710 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693216008711 DNA binding site [nucleotide binding] 693216008712 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 693216008713 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 693216008714 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 693216008715 hypothetical protein; Provisional; Region: PRK09867 693216008716 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 693216008717 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 693216008718 acyl-activating enzyme (AAE) consensus motif; other site 693216008719 putative AMP binding site [chemical binding]; other site 693216008720 putative active site [active] 693216008721 putative CoA binding site [chemical binding]; other site 693216008722 O-succinylbenzoate synthase; Provisional; Region: PRK05105 693216008723 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 693216008724 active site 693216008725 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 693216008726 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693216008727 substrate binding site [chemical binding]; other site 693216008728 oxyanion hole (OAH) forming residues; other site 693216008729 trimer interface [polypeptide binding]; other site 693216008730 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 693216008731 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 693216008732 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 693216008733 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 693216008734 dimer interface [polypeptide binding]; other site 693216008735 tetramer interface [polypeptide binding]; other site 693216008736 PYR/PP interface [polypeptide binding]; other site 693216008737 TPP binding site [chemical binding]; other site 693216008738 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 693216008739 TPP-binding site; other site 693216008740 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 693216008741 chorismate binding enzyme; Region: Chorismate_bind; cl10555 693216008742 hypothetical protein; Provisional; Region: PRK10404 693216008743 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693216008744 Coenzyme A binding pocket [chemical binding]; other site 693216008745 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 693216008746 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 693216008747 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 693216008748 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 693216008749 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 693216008750 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 693216008751 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 693216008752 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 693216008753 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 693216008754 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 693216008755 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 693216008756 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 693216008757 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 693216008758 NADH dehydrogenase subunit G; Validated; Region: PRK08166 693216008759 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693216008760 catalytic loop [active] 693216008761 iron binding site [ion binding]; other site 693216008762 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 693216008763 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 693216008764 [4Fe-4S] binding site [ion binding]; other site 693216008765 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 693216008766 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 693216008767 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 693216008768 SLBB domain; Region: SLBB; pfam10531 693216008769 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 693216008770 NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905 693216008771 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 693216008772 putative dimer interface [polypeptide binding]; other site 693216008773 [2Fe-2S] cluster binding site [ion binding]; other site 693216008774 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852 693216008775 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 693216008776 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 693216008777 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 693216008778 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 693216008779 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 693216008780 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216008781 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 693216008782 putative dimerization interface [polypeptide binding]; other site 693216008783 aminotransferase AlaT; Validated; Region: PRK09265 693216008784 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693216008785 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216008786 homodimer interface [polypeptide binding]; other site 693216008787 catalytic residue [active] 693216008788 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693216008789 Zn2+ binding site [ion binding]; other site 693216008790 Mg2+ binding site [ion binding]; other site 693216008791 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 693216008792 transmembrane helices; other site 693216008793 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 693216008794 TrkA-C domain; Region: TrkA_C; pfam02080 693216008795 TrkA-C domain; Region: TrkA_C; pfam02080 693216008796 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 693216008797 putative phosphatase; Provisional; Region: PRK11587 693216008798 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693216008799 active site 693216008800 motif I; other site 693216008801 motif II; other site 693216008802 hypothetical protein; Validated; Region: PRK05445 693216008803 hypothetical protein; Provisional; Region: PRK01816 693216008804 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 693216008805 phosphate acetyltransferase; Reviewed; Region: PRK05632 693216008806 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 693216008807 DRTGG domain; Region: DRTGG; pfam07085 693216008808 phosphate acetyltransferase; Region: pta; TIGR00651 693216008809 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 693216008810 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 693216008811 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693216008812 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693216008813 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693216008814 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693216008815 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 693216008816 nudix motif; other site 693216008817 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 693216008818 active site 693216008819 metal binding site [ion binding]; metal-binding site 693216008820 homotetramer interface [polypeptide binding]; other site 693216008821 glutathione S-transferase; Provisional; Region: PRK15113 693216008822 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 693216008823 C-terminal domain interface [polypeptide binding]; other site 693216008824 GSH binding site (G-site) [chemical binding]; other site 693216008825 dimer interface [polypeptide binding]; other site 693216008826 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 693216008827 N-terminal domain interface [polypeptide binding]; other site 693216008828 putative dimer interface [polypeptide binding]; other site 693216008829 putative substrate binding pocket (H-site) [chemical binding]; other site 693216008830 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 693216008831 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 693216008832 C-terminal domain interface [polypeptide binding]; other site 693216008833 GSH binding site (G-site) [chemical binding]; other site 693216008834 dimer interface [polypeptide binding]; other site 693216008835 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 693216008836 N-terminal domain interface [polypeptide binding]; other site 693216008837 putative dimer interface [polypeptide binding]; other site 693216008838 active site 693216008839 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 693216008840 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 693216008841 putative NAD(P) binding site [chemical binding]; other site 693216008842 putative active site [active] 693216008843 RES domain; Region: RES; smart00953 693216008844 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 693216008845 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 693216008846 Walker A/P-loop; other site 693216008847 ATP binding site [chemical binding]; other site 693216008848 Q-loop/lid; other site 693216008849 ABC transporter signature motif; other site 693216008850 Walker B; other site 693216008851 D-loop; other site 693216008852 H-loop/switch region; other site 693216008853 ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism]; Region: ArtM; COG4160 693216008854 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216008855 dimer interface [polypeptide binding]; other site 693216008856 conserved gate region; other site 693216008857 putative PBP binding loops; other site 693216008858 ABC-ATPase subunit interface; other site 693216008859 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 693216008860 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216008861 dimer interface [polypeptide binding]; other site 693216008862 conserved gate region; other site 693216008863 putative PBP binding loops; other site 693216008864 ABC-ATPase subunit interface; other site 693216008865 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 693216008866 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693216008867 substrate binding pocket [chemical binding]; other site 693216008868 membrane-bound complex binding site; other site 693216008869 hinge residues; other site 693216008870 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 693216008871 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693216008872 substrate binding pocket [chemical binding]; other site 693216008873 membrane-bound complex binding site; other site 693216008874 hinge residues; other site 693216008875 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 693216008876 amidophosphoribosyltransferase; Provisional; Region: PRK09246 693216008877 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 693216008878 active site 693216008879 tetramer interface [polypeptide binding]; other site 693216008880 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693216008881 active site 693216008882 colicin V production protein; Provisional; Region: PRK10845 693216008883 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 693216008884 cell division protein DedD; Provisional; Region: PRK11633 693216008885 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 693216008886 Sporulation related domain; Region: SPOR; pfam05036 693216008887 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 693216008888 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693216008889 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 693216008890 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 693216008891 hypothetical protein; Provisional; Region: PRK10847 693216008892 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 693216008893 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 693216008894 dimerization interface 3.5A [polypeptide binding]; other site 693216008895 active site 693216008896 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 693216008897 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 693216008898 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 693216008899 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 693216008900 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 693216008901 ligand binding site [chemical binding]; other site 693216008902 NAD binding site [chemical binding]; other site 693216008903 catalytic site [active] 693216008904 homodimer interface [polypeptide binding]; other site 693216008905 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 693216008906 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 693216008907 Subtilase family; Region: Peptidase_S8; pfam00082 693216008908 catalytic triad [active] 693216008909 putative active site [active] 693216008910 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 693216008911 Autotransporter beta-domain; Region: Autotransporter; smart00869 693216008912 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 693216008913 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 693216008914 dimer interface [polypeptide binding]; other site 693216008915 active site 693216008916 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 693216008917 Uncharacterized conserved protein [Function unknown]; Region: COG4121 693216008918 tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197 693216008919 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 693216008920 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 693216008921 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693216008922 dimer interface [polypeptide binding]; other site 693216008923 putative CheW interface [polypeptide binding]; other site 693216008924 YfcL protein; Region: YfcL; pfam08891 693216008925 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 693216008926 hypothetical protein; Provisional; Region: PRK10621 693216008927 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 693216008928 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 693216008929 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 693216008930 Tetramer interface [polypeptide binding]; other site 693216008931 active site 693216008932 FMN-binding site [chemical binding]; other site 693216008933 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK11805 693216008934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693216008935 S-adenosylmethionine binding site [chemical binding]; other site 693216008936 hypothetical protein; Provisional; Region: PRK04946 693216008937 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 693216008938 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 693216008939 catalytic core [active] 693216008940 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 693216008941 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693216008942 substrate binding site [chemical binding]; other site 693216008943 oxyanion hole (OAH) forming residues; other site 693216008944 trimer interface [polypeptide binding]; other site 693216008945 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 693216008946 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 693216008947 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 693216008948 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 693216008949 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 693216008950 dimer interface [polypeptide binding]; other site 693216008951 active site 693216008952 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 693216008953 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 693216008954 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 693216008955 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 693216008956 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693216008957 binding surface 693216008958 TPR motif; other site 693216008959 Tetratricopeptide repeat; Region: TPR_16; pfam13432 693216008960 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 693216008961 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 693216008962 catalytic residues [active] 693216008963 central insert; other site 693216008964 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 693216008965 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150 693216008966 Heme exporter protein D (CcmD); Region: CcmD; cl11475 693216008967 heme exporter protein CcmC; Region: ccmC; TIGR01191 693216008968 heme exporter protein CcmB; Region: ccmB; TIGR01190 693216008969 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 693216008970 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 693216008971 Walker A/P-loop; other site 693216008972 ATP binding site [chemical binding]; other site 693216008973 Q-loop/lid; other site 693216008974 ABC transporter signature motif; other site 693216008975 Walker B; other site 693216008976 D-loop; other site 693216008977 H-loop/switch region; other site 693216008978 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 693216008979 potential frameshift: common BLAST hit: gi|311279010|ref|YP_003941241.1| Integrase catalytic region 693216008980 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693216008981 Integrase core domain; Region: rve; pfam00665 693216008982 HTH-like domain; Region: HTH_21; pfam13276 693216008983 Transposase; Region: HTH_Tnp_1; pfam01527 693216008984 Uncharacterized conserved protein [Function unknown]; Region: COG1683 693216008985 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 693216008986 amphipathic channel; other site 693216008987 Asn-Pro-Ala signature motifs; other site 693216008988 acetoin reductase; Validated; Region: PRK08643 693216008989 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 693216008990 NAD binding site [chemical binding]; other site 693216008991 homotetramer interface [polypeptide binding]; other site 693216008992 homodimer interface [polypeptide binding]; other site 693216008993 active site 693216008994 substrate binding site [chemical binding]; other site 693216008995 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 693216008996 TPP-binding site [chemical binding]; other site 693216008997 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 693216008998 PYR/PP interface [polypeptide binding]; other site 693216008999 dimer interface [polypeptide binding]; other site 693216009000 TPP binding site [chemical binding]; other site 693216009001 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 693216009002 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 693216009003 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693216009004 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216009005 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693216009006 dimerization interface [polypeptide binding]; other site 693216009007 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 693216009008 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 693216009009 oligomer interface [polypeptide binding]; other site 693216009010 metal binding site [ion binding]; metal-binding site 693216009011 metal binding site [ion binding]; metal-binding site 693216009012 putative Cl binding site [ion binding]; other site 693216009013 basic sphincter; other site 693216009014 hydrophobic gate; other site 693216009015 periplasmic entrance; other site 693216009016 Cupin domain; Region: Cupin_2; pfam07883 693216009017 aminotransferase; Validated; Region: PRK08175 693216009018 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693216009019 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216009020 homodimer interface [polypeptide binding]; other site 693216009021 catalytic residue [active] 693216009022 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 693216009023 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 693216009024 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 693216009025 GAF domain; Region: GAF; pfam01590 693216009026 Histidine kinase; Region: His_kinase; pfam06580 693216009027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693216009028 ATP binding site [chemical binding]; other site 693216009029 Mg2+ binding site [ion binding]; other site 693216009030 G-X-G motif; other site 693216009031 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 693216009032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693216009033 active site 693216009034 phosphorylation site [posttranslational modification] 693216009035 intermolecular recognition site; other site 693216009036 dimerization interface [polypeptide binding]; other site 693216009037 LytTr DNA-binding domain; Region: LytTR; pfam04397 693216009038 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 693216009039 nucleotide binding site [chemical binding]; other site 693216009040 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 693216009041 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 693216009042 dimer interface [polypeptide binding]; other site 693216009043 PYR/PP interface [polypeptide binding]; other site 693216009044 TPP binding site [chemical binding]; other site 693216009045 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 693216009046 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 693216009047 TPP-binding site [chemical binding]; other site 693216009048 dimer interface [polypeptide binding]; other site 693216009049 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693216009050 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 693216009051 active site 693216009052 catalytic tetrad [active] 693216009053 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 693216009054 manganese transport protein MntH; Reviewed; Region: PRK00701 693216009055 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 693216009056 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 693216009057 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 693216009058 Nucleoside recognition; Region: Gate; pfam07670 693216009059 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 693216009060 MASE1; Region: MASE1; cl17823 693216009061 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 693216009062 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693216009063 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 693216009064 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 693216009065 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 693216009066 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 693216009067 active site 693216009068 HIGH motif; other site 693216009069 KMSKS motif; other site 693216009070 Protein of unknown function (DUF3150); Region: DUF3150; pfam11348 693216009071 FlxA-like protein; Region: FlxA; pfam14282 693216009072 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 693216009073 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 693216009074 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 693216009075 nucleotide binding pocket [chemical binding]; other site 693216009076 K-X-D-G motif; other site 693216009077 catalytic site [active] 693216009078 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 693216009079 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 693216009080 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 693216009081 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 693216009082 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 693216009083 Dimer interface [polypeptide binding]; other site 693216009084 BRCT sequence motif; other site 693216009085 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 693216009086 FtsZ protein binding site [polypeptide binding]; other site 693216009087 putative sulfate transport protein CysZ; Validated; Region: PRK04949 693216009088 cysteine synthase; Region: PLN02565 693216009089 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 693216009090 dimer interface [polypeptide binding]; other site 693216009091 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216009092 catalytic residue [active] 693216009093 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 693216009094 dimerization domain swap beta strand [polypeptide binding]; other site 693216009095 regulatory protein interface [polypeptide binding]; other site 693216009096 active site 693216009097 regulatory phosphorylation site [posttranslational modification]; other site 693216009098 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 693216009099 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 693216009100 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 693216009101 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 693216009102 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 693216009103 HPr interaction site; other site 693216009104 glycerol kinase (GK) interaction site [polypeptide binding]; other site 693216009105 active site 693216009106 phosphorylation site [posttranslational modification] 693216009107 cysteine synthase; Region: PLN02565 693216009108 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 693216009109 dimer interface [polypeptide binding]; other site 693216009110 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216009111 catalytic residue [active] 693216009112 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 693216009113 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 693216009114 Walker A/P-loop; other site 693216009115 ATP binding site [chemical binding]; other site 693216009116 Q-loop/lid; other site 693216009117 ABC transporter signature motif; other site 693216009118 Walker B; other site 693216009119 D-loop; other site 693216009120 H-loop/switch region; other site 693216009121 TOBE-like domain; Region: TOBE_3; pfam12857 693216009122 sulfate transport protein; Provisional; Region: cysT; CHL00187 693216009123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216009124 dimer interface [polypeptide binding]; other site 693216009125 conserved gate region; other site 693216009126 putative PBP binding loops; other site 693216009127 ABC-ATPase subunit interface; other site 693216009128 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 693216009129 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216009130 dimer interface [polypeptide binding]; other site 693216009131 conserved gate region; other site 693216009132 putative PBP binding loops; other site 693216009133 ABC-ATPase subunit interface; other site 693216009134 thiosulfate transporter subunit; Provisional; Region: PRK10852 693216009135 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 693216009136 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 693216009137 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 693216009138 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 693216009139 putative acetyltransferase; Provisional; Region: PRK03624 693216009140 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693216009141 Coenzyme A binding pocket [chemical binding]; other site 693216009142 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 693216009143 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 693216009144 active site 693216009145 metal binding site [ion binding]; metal-binding site 693216009146 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 693216009147 Initiation factor 2 subunit family; Region: IF-2B; cl00348 693216009148 Initiation factor 2 subunit family; Region: IF-2B; cl00348 693216009149 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 693216009150 Uncharacterized conserved protein [Function unknown]; Region: COG5276 693216009151 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 693216009152 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 693216009153 putative ligand binding site [chemical binding]; other site 693216009154 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693216009155 TM-ABC transporter signature motif; other site 693216009156 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 693216009157 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693216009158 Walker A/P-loop; other site 693216009159 ATP binding site [chemical binding]; other site 693216009160 Q-loop/lid; other site 693216009161 ABC transporter signature motif; other site 693216009162 Walker B; other site 693216009163 D-loop; other site 693216009164 H-loop/switch region; other site 693216009165 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693216009166 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 693216009167 putative active site [active] 693216009168 metal binding site [ion binding]; metal-binding site 693216009169 enterobactin exporter EntS; Provisional; Region: PRK10489 693216009170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216009171 putative substrate translocation pore; other site 693216009172 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 693216009173 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693216009174 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693216009175 salt bridge; other site 693216009176 non-specific DNA binding site [nucleotide binding]; other site 693216009177 sequence-specific DNA binding site [nucleotide binding]; other site 693216009178 Uncharacterized small protein [Function unknown]; Region: COG2879 693216009179 carbon starvation protein A; Provisional; Region: PRK15015 693216009180 Carbon starvation protein CstA; Region: CstA; pfam02554 693216009181 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 693216009182 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 693216009183 CoenzymeA binding site [chemical binding]; other site 693216009184 subunit interaction site [polypeptide binding]; other site 693216009185 PHB binding site; other site 693216009186 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 693216009187 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 693216009188 NAD(P) binding site [chemical binding]; other site 693216009189 active site 693216009190 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 693216009191 hydrophobic substrate binding pocket; other site 693216009192 active site 693216009193 conserved cis-peptide bond; other site 693216009194 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 693216009195 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 693216009196 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 693216009197 acyl-activating enzyme (AAE) consensus motif; other site 693216009198 active site 693216009199 AMP binding site [chemical binding]; other site 693216009200 substrate binding site [chemical binding]; other site 693216009201 isochorismate synthase EntC; Provisional; Region: PRK15016 693216009202 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 693216009203 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 693216009204 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 693216009205 siderophore binding site; other site 693216009206 enterobactin exporter EntS; Provisional; Region: PRK10489 693216009207 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216009208 putative substrate translocation pore; other site 693216009209 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 693216009210 ABC-ATPase subunit interface; other site 693216009211 dimer interface [polypeptide binding]; other site 693216009212 putative PBP binding regions; other site 693216009213 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 693216009214 ABC-ATPase subunit interface; other site 693216009215 dimer interface [polypeptide binding]; other site 693216009216 putative PBP binding regions; other site 693216009217 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 693216009218 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 693216009219 Walker A/P-loop; other site 693216009220 ATP binding site [chemical binding]; other site 693216009221 Q-loop/lid; other site 693216009222 ABC transporter signature motif; other site 693216009223 Walker B; other site 693216009224 D-loop; other site 693216009225 H-loop/switch region; other site 693216009226 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 693216009227 Malic enzyme, N-terminal domain; Region: malic; pfam00390 693216009228 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 693216009229 putative NAD(P) binding site [chemical binding]; other site 693216009230 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 693216009231 transaldolase-like protein; Provisional; Region: PTZ00411 693216009232 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 693216009233 active site 693216009234 dimer interface [polypeptide binding]; other site 693216009235 catalytic residue [active] 693216009236 transketolase; Reviewed; Region: PRK12753 693216009237 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 693216009238 TPP-binding site [chemical binding]; other site 693216009239 dimer interface [polypeptide binding]; other site 693216009240 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 693216009241 PYR/PP interface [polypeptide binding]; other site 693216009242 dimer interface [polypeptide binding]; other site 693216009243 TPP binding site [chemical binding]; other site 693216009244 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 693216009245 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 693216009246 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 693216009247 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 693216009248 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 693216009249 dimer interface [polypeptide binding]; other site 693216009250 ADP-ribose binding site [chemical binding]; other site 693216009251 active site 693216009252 nudix motif; other site 693216009253 metal binding site [ion binding]; metal-binding site 693216009254 transcriptional regulator NarP; Provisional; Region: PRK10403 693216009255 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693216009256 active site 693216009257 phosphorylation site [posttranslational modification] 693216009258 intermolecular recognition site; other site 693216009259 dimerization interface [polypeptide binding]; other site 693216009260 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693216009261 DNA binding residues [nucleotide binding] 693216009262 dimerization interface [polypeptide binding]; other site 693216009263 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 693216009264 MMPL family; Region: MMPL; cl14618 693216009265 MMPL family; Region: MMPL; cl14618 693216009266 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 693216009267 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693216009268 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 693216009269 Coenzyme A binding pocket [chemical binding]; other site 693216009270 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 693216009271 putative catalytic residues [active] 693216009272 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 693216009273 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 693216009274 metal binding site [ion binding]; metal-binding site 693216009275 dimer interface [polypeptide binding]; other site 693216009276 hypothetical protein; Provisional; Region: PRK13664 693216009277 putative hydrolase; Provisional; Region: PRK11460 693216009278 Predicted esterase [General function prediction only]; Region: COG0400 693216009279 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 693216009280 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 693216009281 Helicase; Region: Helicase_RecD; pfam05127 693216009282 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693216009283 Coenzyme A binding pocket [chemical binding]; other site 693216009284 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 693216009285 Predicted metalloprotease [General function prediction only]; Region: COG2321 693216009286 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 693216009287 ATP binding site [chemical binding]; other site 693216009288 active site 693216009289 substrate binding site [chemical binding]; other site 693216009290 lipoprotein; Provisional; Region: PRK11679 693216009291 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 693216009292 dimer interface [polypeptide binding]; other site 693216009293 active site 693216009294 catalytic residue [active] 693216009295 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 693216009296 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 693216009297 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 693216009298 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 693216009299 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 693216009300 catalytic triad [active] 693216009301 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 693216009302 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 693216009303 Peptidase family M48; Region: Peptidase_M48; cl12018 693216009304 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 693216009305 catalytic residues [active] 693216009306 DNA replication initiation factor; Provisional; Region: PRK08084 693216009307 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 693216009308 uracil transporter; Provisional; Region: PRK10720 693216009309 uracil-xanthine permease; Region: ncs2; TIGR00801 693216009310 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693216009311 active site 693216009312 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 693216009313 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 693216009314 dimerization interface [polypeptide binding]; other site 693216009315 putative ATP binding site [chemical binding]; other site 693216009316 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 693216009317 active site 693216009318 substrate binding site [chemical binding]; other site 693216009319 cosubstrate binding site; other site 693216009320 catalytic site [active] 693216009321 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 693216009322 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 693216009323 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 693216009324 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 693216009325 putative active site [active] 693216009326 catalytic site [active] 693216009327 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 693216009328 domain interface [polypeptide binding]; other site 693216009329 active site 693216009330 catalytic site [active] 693216009331 exopolyphosphatase; Provisional; Region: PRK10854 693216009332 exopolyphosphatase; Region: exo_poly_only; TIGR03706 693216009333 MASE1; Region: MASE1; cl17823 693216009334 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 693216009335 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693216009336 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 693216009337 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 693216009338 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693216009339 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693216009340 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693216009341 galactoside permease; Reviewed; Region: lacY; PRK09528 693216009342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216009343 putative substrate translocation pore; other site 693216009344 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 693216009345 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 693216009346 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 693216009347 substrate binding site [chemical binding]; other site 693216009348 catalytic residues [active] 693216009349 GMP synthase; Reviewed; Region: guaA; PRK00074 693216009350 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 693216009351 AMP/PPi binding site [chemical binding]; other site 693216009352 candidate oxyanion hole; other site 693216009353 catalytic triad [active] 693216009354 potential glutamine specificity residues [chemical binding]; other site 693216009355 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 693216009356 ATP Binding subdomain [chemical binding]; other site 693216009357 Ligand Binding sites [chemical binding]; other site 693216009358 Dimerization subdomain; other site 693216009359 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 693216009360 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 693216009361 active site 693216009362 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 693216009363 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 693216009364 generic binding surface II; other site 693216009365 generic binding surface I; other site 693216009366 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 693216009367 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 693216009368 active site 693216009369 Zn binding site [ion binding]; other site 693216009370 zinc-ribbons; Region: zinc-ribbons_6; pfam07191 693216009371 GTP-binding protein Der; Reviewed; Region: PRK00093 693216009372 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 693216009373 G1 box; other site 693216009374 GTP/Mg2+ binding site [chemical binding]; other site 693216009375 Switch I region; other site 693216009376 G2 box; other site 693216009377 Switch II region; other site 693216009378 G3 box; other site 693216009379 G4 box; other site 693216009380 G5 box; other site 693216009381 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 693216009382 G1 box; other site 693216009383 GTP/Mg2+ binding site [chemical binding]; other site 693216009384 Switch I region; other site 693216009385 G2 box; other site 693216009386 G3 box; other site 693216009387 Switch II region; other site 693216009388 G4 box; other site 693216009389 G5 box; other site 693216009390 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 693216009391 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 693216009392 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 693216009393 Trp docking motif [polypeptide binding]; other site 693216009394 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 693216009395 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 693216009396 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 693216009397 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 693216009398 dimer interface [polypeptide binding]; other site 693216009399 motif 1; other site 693216009400 active site 693216009401 motif 2; other site 693216009402 motif 3; other site 693216009403 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 693216009404 anticodon binding site; other site 693216009405 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 693216009406 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 693216009407 cytoskeletal protein RodZ; Provisional; Region: PRK10856 693216009408 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693216009409 non-specific DNA binding site [nucleotide binding]; other site 693216009410 salt bridge; other site 693216009411 sequence-specific DNA binding site [nucleotide binding]; other site 693216009412 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 693216009413 23S rRNA m2A2503 methyltransferase; Region: TIGR00048 693216009414 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693216009415 FeS/SAM binding site; other site 693216009416 Nucleoside diphosphate kinase; Region: NDK; pfam00334 693216009417 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 693216009418 active site 693216009419 multimer interface [polypeptide binding]; other site 693216009420 penicillin-binding protein 1C; Provisional; Region: PRK11240 693216009421 Transglycosylase; Region: Transgly; pfam00912 693216009422 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 693216009423 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 693216009424 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 693216009425 MG2 domain; Region: A2M_N; pfam01835 693216009426 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 693216009427 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 693216009428 surface patch; other site 693216009429 thioester region; other site 693216009430 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 693216009431 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 693216009432 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 693216009433 active site turn [active] 693216009434 phosphorylation site [posttranslational modification] 693216009435 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 693216009436 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 693216009437 NAD binding site [chemical binding]; other site 693216009438 sugar binding site [chemical binding]; other site 693216009439 divalent metal binding site [ion binding]; other site 693216009440 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 693216009441 dimer interface [polypeptide binding]; other site 693216009442 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 693216009443 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 693216009444 active site residue [active] 693216009445 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 693216009446 active site residue [active] 693216009447 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 693216009448 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 693216009449 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 693216009450 putative active site [active] 693216009451 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 693216009452 Peptidase family M48; Region: Peptidase_M48; cl12018 693216009453 SseB protein N-terminal domain; Region: SseB; pfam07179 693216009454 SseB protein C-terminal domain; Region: SseB_C; pfam14581 693216009455 aminopeptidase B; Provisional; Region: PRK05015 693216009456 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 693216009457 interface (dimer of trimers) [polypeptide binding]; other site 693216009458 Substrate-binding/catalytic site; other site 693216009459 Zn-binding sites [ion binding]; other site 693216009460 hypothetical protein; Provisional; Region: PRK10721 693216009461 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 693216009462 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693216009463 catalytic loop [active] 693216009464 iron binding site [ion binding]; other site 693216009465 chaperone protein HscA; Provisional; Region: hscA; PRK05183 693216009466 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 693216009467 nucleotide binding site [chemical binding]; other site 693216009468 putative NEF/HSP70 interaction site [polypeptide binding]; other site 693216009469 SBD interface [polypeptide binding]; other site 693216009470 co-chaperone HscB; Provisional; Region: hscB; PRK05014 693216009471 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 693216009472 HSP70 interaction site [polypeptide binding]; other site 693216009473 HSCB C-terminal oligomerization domain; Region: HSCB_C; pfam07743 693216009474 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 693216009475 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 693216009476 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 693216009477 trimerization site [polypeptide binding]; other site 693216009478 active site 693216009479 cysteine desulfurase; Provisional; Region: PRK14012 693216009480 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 693216009481 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693216009482 catalytic residue [active] 693216009483 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 693216009484 Rrf2 family protein; Region: rrf2_super; TIGR00738 693216009485 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 693216009486 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 693216009487 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 693216009488 active site 693216009489 dimerization interface [polypeptide binding]; other site 693216009490 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 693216009491 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 693216009492 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 693216009493 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 693216009494 PRD domain; Region: PRD; pfam00874 693216009495 PRD domain; Region: PRD; pfam00874 693216009496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216009497 sugar efflux transporter; Region: 2A0120; TIGR00899 693216009498 putative substrate translocation pore; other site 693216009499 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 693216009500 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 693216009501 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 693216009502 DNA binding residues [nucleotide binding] 693216009503 putative dimer interface [polypeptide binding]; other site 693216009504 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 693216009505 dimer interface [polypeptide binding]; other site 693216009506 active site 693216009507 glycine-pyridoxal phosphate binding site [chemical binding]; other site 693216009508 folate binding site [chemical binding]; other site 693216009509 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 693216009510 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 693216009511 heme-binding site [chemical binding]; other site 693216009512 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 693216009513 FAD binding pocket [chemical binding]; other site 693216009514 FAD binding motif [chemical binding]; other site 693216009515 phosphate binding motif [ion binding]; other site 693216009516 beta-alpha-beta structure motif; other site 693216009517 NAD binding pocket [chemical binding]; other site 693216009518 Heme binding pocket [chemical binding]; other site 693216009519 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 693216009520 Nitrogen regulatory protein P-II; Region: P-II; smart00938 693216009521 response regulator GlrR; Provisional; Region: PRK15115 693216009522 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693216009523 active site 693216009524 phosphorylation site [posttranslational modification] 693216009525 intermolecular recognition site; other site 693216009526 dimerization interface [polypeptide binding]; other site 693216009527 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693216009528 Walker A motif; other site 693216009529 ATP binding site [chemical binding]; other site 693216009530 Walker B motif; other site 693216009531 arginine finger; other site 693216009532 hypothetical protein; Provisional; Region: PRK10722 693216009533 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693216009534 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693216009535 dimer interface [polypeptide binding]; other site 693216009536 phosphorylation site [posttranslational modification] 693216009537 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693216009538 ATP binding site [chemical binding]; other site 693216009539 Mg2+ binding site [ion binding]; other site 693216009540 G-X-G motif; other site 693216009541 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 693216009542 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 693216009543 dimerization interface [polypeptide binding]; other site 693216009544 ATP binding site [chemical binding]; other site 693216009545 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 693216009546 dimerization interface [polypeptide binding]; other site 693216009547 ATP binding site [chemical binding]; other site 693216009548 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 693216009549 putative active site [active] 693216009550 catalytic triad [active] 693216009551 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 693216009552 nucleoside/Zn binding site; other site 693216009553 dimer interface [polypeptide binding]; other site 693216009554 catalytic motif [active] 693216009555 hypothetical protein; Provisional; Region: PRK11590 693216009556 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 693216009557 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 693216009558 active site turn [active] 693216009559 phosphorylation site [posttranslational modification] 693216009560 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 693216009561 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 693216009562 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 693216009563 putative active site [active] 693216009564 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 693216009565 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 693216009566 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 693216009567 putative active site [active] 693216009568 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 693216009569 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 693216009570 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 693216009571 active site 693216009572 hydrophilic channel; other site 693216009573 dimerization interface [polypeptide binding]; other site 693216009574 catalytic residues [active] 693216009575 active site lid [active] 693216009576 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 693216009577 Recombination protein O N terminal; Region: RecO_N; pfam11967 693216009578 Recombination protein O C terminal; Region: RecO_C; pfam02565 693216009579 GTPase Era; Reviewed; Region: era; PRK00089 693216009580 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 693216009581 G1 box; other site 693216009582 GTP/Mg2+ binding site [chemical binding]; other site 693216009583 Switch I region; other site 693216009584 G2 box; other site 693216009585 Switch II region; other site 693216009586 G3 box; other site 693216009587 G4 box; other site 693216009588 G5 box; other site 693216009589 KH domain; Region: KH_2; pfam07650 693216009590 ribonuclease III; Reviewed; Region: rnc; PRK00102 693216009591 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 693216009592 dimerization interface [polypeptide binding]; other site 693216009593 active site 693216009594 metal binding site [ion binding]; metal-binding site 693216009595 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 693216009596 dsRNA binding site [nucleotide binding]; other site 693216009597 signal peptidase I; Provisional; Region: PRK10861 693216009598 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 693216009599 Catalytic site [active] 693216009600 GTP-binding protein LepA; Provisional; Region: PRK05433 693216009601 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 693216009602 G1 box; other site 693216009603 putative GEF interaction site [polypeptide binding]; other site 693216009604 GTP/Mg2+ binding site [chemical binding]; other site 693216009605 Switch I region; other site 693216009606 G2 box; other site 693216009607 G3 box; other site 693216009608 Switch II region; other site 693216009609 G4 box; other site 693216009610 G5 box; other site 693216009611 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 693216009612 Elongation Factor G, domain II; Region: EFG_II; pfam14492 693216009613 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 693216009614 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 693216009615 SoxR reducing system protein RseC; Provisional; Region: PRK10862 693216009616 anti-sigma E factor; Provisional; Region: rseB; PRK09455 693216009617 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 693216009618 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 693216009619 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 693216009620 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 693216009621 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693216009622 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693216009623 DNA binding residues [nucleotide binding] 693216009624 L-aspartate oxidase; Provisional; Region: PRK09077 693216009625 L-aspartate oxidase; Provisional; Region: PRK06175 693216009626 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 693216009627 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 693216009628 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693216009629 S-adenosylmethionine binding site [chemical binding]; other site 693216009630 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 693216009631 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 693216009632 ATP binding site [chemical binding]; other site 693216009633 Mg++ binding site [ion binding]; other site 693216009634 motif III; other site 693216009635 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693216009636 nucleotide binding region [chemical binding]; other site 693216009637 ATP-binding site [chemical binding]; other site 693216009638 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 693216009639 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 693216009640 ligand binding site [chemical binding]; other site 693216009641 active site 693216009642 UGI interface [polypeptide binding]; other site 693216009643 catalytic site [active] 693216009644 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 693216009645 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 693216009646 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 693216009647 thioredoxin 2; Provisional; Region: PRK10996 693216009648 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 693216009649 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 693216009650 catalytic residues [active] 693216009651 Uncharacterized conserved protein [Function unknown]; Region: COG3148 693216009652 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 693216009653 CoA binding domain; Region: CoA_binding_2; pfam13380 693216009654 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 693216009655 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 693216009656 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 693216009657 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693216009658 Coenzyme A binding pocket [chemical binding]; other site 693216009659 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 693216009660 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 693216009661 domain interface [polypeptide binding]; other site 693216009662 putative active site [active] 693216009663 catalytic site [active] 693216009664 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 693216009665 domain interface [polypeptide binding]; other site 693216009666 putative active site [active] 693216009667 catalytic site [active] 693216009668 lipoprotein; Provisional; Region: PRK10759 693216009669 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 693216009670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216009671 putative substrate translocation pore; other site 693216009672 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 693216009673 thiamine pyrophosphate protein; Provisional; Region: PRK08273 693216009674 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 693216009675 PYR/PP interface [polypeptide binding]; other site 693216009676 dimer interface [polypeptide binding]; other site 693216009677 tetramer interface [polypeptide binding]; other site 693216009678 TPP binding site [chemical binding]; other site 693216009679 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 693216009680 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 693216009681 TPP-binding site [chemical binding]; other site 693216009682 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693216009683 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693216009684 non-specific DNA binding site [nucleotide binding]; other site 693216009685 salt bridge; other site 693216009686 sequence-specific DNA binding site [nucleotide binding]; other site 693216009687 2TM domain; Region: 2TM; pfam13239 693216009688 protein disaggregation chaperone; Provisional; Region: PRK10865 693216009689 Clp amino terminal domain; Region: Clp_N; pfam02861 693216009690 Clp amino terminal domain; Region: Clp_N; pfam02861 693216009691 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693216009692 Walker A motif; other site 693216009693 ATP binding site [chemical binding]; other site 693216009694 Walker B motif; other site 693216009695 arginine finger; other site 693216009696 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693216009697 Walker A motif; other site 693216009698 ATP binding site [chemical binding]; other site 693216009699 Walker B motif; other site 693216009700 arginine finger; other site 693216009701 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 693216009702 hypothetical protein; Provisional; Region: PRK10723 693216009703 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 693216009704 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693216009705 RNA binding surface [nucleotide binding]; other site 693216009706 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 693216009707 active site 693216009708 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 693216009709 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 693216009710 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 693216009711 30S subunit binding site; other site 693216009712 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 693216009713 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 693216009714 Prephenate dehydratase; Region: PDT; pfam00800 693216009715 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 693216009716 putative L-Phe binding site [chemical binding]; other site 693216009717 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 693216009718 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 693216009719 Chorismate mutase type II; Region: CM_2; cl00693 693216009720 prephenate dehydrogenase; Validated; Region: PRK08507 693216009721 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 693216009722 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 693216009723 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 693216009724 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 693216009725 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 693216009726 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 693216009727 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 693216009728 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 693216009729 RimM N-terminal domain; Region: RimM; pfam01782 693216009730 PRC-barrel domain; Region: PRC; pfam05239 693216009731 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 693216009732 signal recognition particle protein; Provisional; Region: PRK10867 693216009733 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 693216009734 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 693216009735 P loop; other site 693216009736 GTP binding site [chemical binding]; other site 693216009737 Signal peptide binding domain; Region: SRP_SPB; pfam02978 693216009738 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 693216009739 hypothetical protein; Provisional; Region: PRK11573 693216009740 Domain of unknown function DUF21; Region: DUF21; pfam01595 693216009741 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 693216009742 Transporter associated domain; Region: CorC_HlyC; smart01091 693216009743 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 693216009744 dimer interface [polypeptide binding]; other site 693216009745 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 693216009746 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 693216009747 recombination and repair protein; Provisional; Region: PRK10869 693216009748 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 693216009749 Walker A/P-loop; other site 693216009750 ATP binding site [chemical binding]; other site 693216009751 Q-loop/lid; other site 693216009752 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 693216009753 Q-loop/lid; other site 693216009754 ABC transporter signature motif; other site 693216009755 Walker B; other site 693216009756 D-loop; other site 693216009757 H-loop/switch region; other site 693216009758 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 693216009759 hypothetical protein; Validated; Region: PRK01777 693216009760 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 693216009761 putative coenzyme Q binding site [chemical binding]; other site 693216009762 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 693216009763 SmpB-tmRNA interface; other site 693216009764 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 693216009765 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 693216009766 HlyD family secretion protein; Region: HlyD_3; pfam13437 693216009767 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 693216009768 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693216009769 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693216009770 Walker A/P-loop; other site 693216009771 ATP binding site [chemical binding]; other site 693216009772 Q-loop/lid; other site 693216009773 ABC transporter signature motif; other site 693216009774 Walker B; other site 693216009775 D-loop; other site 693216009776 H-loop/switch region; other site 693216009777 potential frameshift: common BLAST hit: gi|322832019|ref|YP_004212046.1| type I secretion outer membrane protein, TolC family 693216009778 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 693216009779 Outer membrane efflux protein; Region: OEP; pfam02321 693216009780 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 693216009781 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693216009782 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693216009783 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693216009784 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693216009785 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693216009786 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693216009787 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693216009788 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693216009789 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693216009790 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693216009791 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693216009792 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693216009793 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693216009794 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693216009795 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693216009796 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693216009797 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693216009798 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693216009799 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693216009800 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693216009801 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693216009802 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693216009803 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693216009804 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693216009805 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693216009806 tail protein; Provisional; Region: D; PHA02561 693216009807 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 693216009808 Phage-related tail protein [Function unknown]; Region: COG5283 693216009809 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 693216009810 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 693216009811 major tail tube protein; Provisional; Region: FII; PHA02600 693216009812 major tail sheath protein; Provisional; Region: FI; PHA02560 693216009813 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 693216009814 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 693216009815 Phage Tail Collar Domain; Region: Collar; pfam07484 693216009816 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 693216009817 baseplate assembly protein; Provisional; Region: J; PHA02568 693216009818 baseplate wedge subunit; Provisional; Region: W; PHA02516 693216009819 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 693216009820 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 693216009821 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 693216009822 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 693216009823 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 693216009824 catalytic residues [active] 693216009825 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 693216009826 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 693216009827 terminase endonuclease subunit; Provisional; Region: M; PHA02537 693216009828 capsid protein; Provisional; Region: N; PHA02538 693216009829 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 693216009830 terminase ATPase subunit; Provisional; Region: P; PHA02535 693216009831 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 693216009832 portal vertex protein; Provisional; Region: Q; PHA02536 693216009833 Uncharacterized conserved protein [Function unknown]; Region: COG4938 693216009834 AAA domain; Region: AAA_21; pfam13304 693216009835 Walker B; other site 693216009836 D-loop; other site 693216009837 H-loop/switch region; other site 693216009838 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 693216009839 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 693216009840 Active Sites [active] 693216009841 DksA-like zinc finger domain containing protein; Region: PHA00080 693216009842 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 693216009843 Protein of unknown function (DUF2724); Region: DUF2724; pfam10893 693216009844 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 693216009845 Predicted transcriptional regulator [Transcription]; Region: COG2932 693216009846 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 693216009847 integrase; Provisional; Region: int; PHA02601 693216009848 Leucine carboxyl methyltransferase; Region: LCM; cl01306 693216009849 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693216009850 active site 693216009851 DNA binding site [nucleotide binding] 693216009852 Int/Topo IB signature motif; other site 693216009853 potential frameshift: common BLAST hit: gi|253988748|ref|YP_003040104.1| prophage cp4-57 integrase 693216009854 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693216009855 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693216009856 active site 693216009857 Int/Topo IB signature motif; other site 693216009858 DNA binding site [nucleotide binding] 693216009859 P-loop containing region of AAA domain; Region: AAA_29; cl17516 693216009860 Protein of unknown function (DUF4435); Region: DUF4435; pfam14491 693216009861 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 693216009862 active site 693216009863 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 693216009864 FIST N domain; Region: FIST; smart00897 693216009865 FIST C domain; Region: FIST_C; pfam10442 693216009866 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 693216009867 dimer interface [polypeptide binding]; other site 693216009868 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 693216009869 putative CheW interface [polypeptide binding]; other site 693216009870 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 693216009871 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 693216009872 hypothetical protein; Provisional; Region: PRK10556 693216009873 hypothetical protein; Provisional; Region: PRK10132 693216009874 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 693216009875 catalytic residues [active] 693216009876 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 693216009877 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 693216009878 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 693216009879 Class I ribonucleotide reductase; Region: RNR_I; cd01679 693216009880 active site 693216009881 dimer interface [polypeptide binding]; other site 693216009882 catalytic residues [active] 693216009883 effector binding site; other site 693216009884 R2 peptide binding site; other site 693216009885 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 693216009886 dimer interface [polypeptide binding]; other site 693216009887 putative radical transfer pathway; other site 693216009888 diiron center [ion binding]; other site 693216009889 tyrosyl radical; other site 693216009890 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 693216009891 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 693216009892 Walker A/P-loop; other site 693216009893 ATP binding site [chemical binding]; other site 693216009894 Q-loop/lid; other site 693216009895 ABC transporter signature motif; other site 693216009896 Walker B; other site 693216009897 D-loop; other site 693216009898 H-loop/switch region; other site 693216009899 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 693216009900 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 693216009901 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 693216009902 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216009903 putative substrate translocation pore; other site 693216009904 transcriptional repressor MprA; Provisional; Region: PRK10870 693216009905 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693216009906 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 693216009907 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693216009908 HlyD family secretion protein; Region: HlyD_3; pfam13437 693216009909 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 693216009910 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216009911 putative substrate translocation pore; other site 693216009912 CHASE4 domain; Region: CHASE4; pfam05228 693216009913 PAS domain S-box; Region: sensory_box; TIGR00229 693216009914 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693216009915 putative active site [active] 693216009916 heme pocket [chemical binding]; other site 693216009917 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693216009918 metal binding site [ion binding]; metal-binding site 693216009919 active site 693216009920 I-site; other site 693216009921 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693216009922 S-ribosylhomocysteinase; Provisional; Region: PRK02260 693216009923 glutamate--cysteine ligase; Provisional; Region: PRK02107 693216009924 Predicted membrane protein [Function unknown]; Region: COG1238 693216009925 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 693216009926 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693216009927 active site 693216009928 motif I; other site 693216009929 motif II; other site 693216009930 carbon storage regulator; Provisional; Region: PRK01712 693216009931 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 693216009932 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 693216009933 motif 1; other site 693216009934 active site 693216009935 motif 2; other site 693216009936 motif 3; other site 693216009937 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 693216009938 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 693216009939 DHHA1 domain; Region: DHHA1; pfam02272 693216009940 recombination regulator RecX; Reviewed; Region: recX; PRK00117 693216009941 recombinase A; Provisional; Region: recA; PRK09354 693216009942 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 693216009943 hexamer interface [polypeptide binding]; other site 693216009944 Walker A motif; other site 693216009945 ATP binding site [chemical binding]; other site 693216009946 Walker B motif; other site 693216009947 hypothetical protein; Validated; Region: PRK03661 693216009948 murein hydrolase B; Provisional; Region: PRK10760 693216009949 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693216009950 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693216009951 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 693216009952 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 693216009953 Walker A/P-loop; other site 693216009954 ATP binding site [chemical binding]; other site 693216009955 Q-loop/lid; other site 693216009956 ABC transporter signature motif; other site 693216009957 Walker B; other site 693216009958 D-loop; other site 693216009959 H-loop/switch region; other site 693216009960 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 693216009961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216009962 dimer interface [polypeptide binding]; other site 693216009963 conserved gate region; other site 693216009964 putative PBP binding loops; other site 693216009965 ABC-ATPase subunit interface; other site 693216009966 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693216009967 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693216009968 substrate binding pocket [chemical binding]; other site 693216009969 membrane-bound complex binding site; other site 693216009970 hinge residues; other site 693216009971 KTSC domain; Region: KTSC; pfam13619 693216009972 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 693216009973 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 693216009974 dimer interface [polypeptide binding]; other site 693216009975 ligand binding site [chemical binding]; other site 693216009976 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693216009977 dimerization interface [polypeptide binding]; other site 693216009978 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693216009979 dimer interface [polypeptide binding]; other site 693216009980 putative CheW interface [polypeptide binding]; other site 693216009981 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 693216009982 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 693216009983 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 693216009984 MutS domain I; Region: MutS_I; pfam01624 693216009985 MutS domain II; Region: MutS_II; pfam05188 693216009986 MutS domain III; Region: MutS_III; pfam05192 693216009987 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 693216009988 Walker A/P-loop; other site 693216009989 ATP binding site [chemical binding]; other site 693216009990 Q-loop/lid; other site 693216009991 ABC transporter signature motif; other site 693216009992 Walker B; other site 693216009993 D-loop; other site 693216009994 H-loop/switch region; other site 693216009995 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 693216009996 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 693216009997 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 693216009998 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693216009999 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 693216010000 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693216010001 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216010002 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693216010003 putative effector binding pocket; other site 693216010004 dimerization interface [polypeptide binding]; other site 693216010005 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216010006 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693216010007 putative substrate translocation pore; other site 693216010008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 693216010009 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 693216010010 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 693216010011 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693216010012 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 693216010013 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693216010014 DNA binding residues [nucleotide binding] 693216010015 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 693216010016 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693216010017 Peptidase family M23; Region: Peptidase_M23; pfam01551 693216010018 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693216010019 S-adenosylmethionine binding site [chemical binding]; other site 693216010020 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 693216010021 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 693216010022 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 693216010023 Permutation of conserved domain; other site 693216010024 active site 693216010025 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 693216010026 homotrimer interaction site [polypeptide binding]; other site 693216010027 zinc binding site [ion binding]; other site 693216010028 CDP-binding sites; other site 693216010029 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 693216010030 substrate binding site; other site 693216010031 dimer interface; other site 693216010032 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 693216010033 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 693216010034 ligand-binding site [chemical binding]; other site 693216010035 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 693216010036 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 693216010037 CysD dimerization site [polypeptide binding]; other site 693216010038 G1 box; other site 693216010039 putative GEF interaction site [polypeptide binding]; other site 693216010040 GTP/Mg2+ binding site [chemical binding]; other site 693216010041 Switch I region; other site 693216010042 G2 box; other site 693216010043 G3 box; other site 693216010044 Switch II region; other site 693216010045 G4 box; other site 693216010046 G5 box; other site 693216010047 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 693216010048 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 693216010049 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 693216010050 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 693216010051 Active Sites [active] 693216010052 siroheme synthase; Provisional; Region: cysG; PRK10637 693216010053 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 693216010054 Sirohaem biosynthesis protein central; Region: Sirohm_synth_M; pfam14824 693216010055 Sirohaem synthase dimerization region; Region: CysG_dimeriser; pfam10414 693216010056 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 693216010057 active site 693216010058 SAM binding site [chemical binding]; other site 693216010059 homodimer interface [polypeptide binding]; other site 693216010060 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 693216010061 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 693216010062 metal binding site [ion binding]; metal-binding site 693216010063 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 693216010064 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 693216010065 Active Sites [active] 693216010066 sulfite reductase subunit beta; Provisional; Region: PRK13504 693216010067 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 693216010068 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 693216010069 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 693216010070 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 693216010071 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 693216010072 Flavodoxin; Region: Flavodoxin_1; pfam00258 693216010073 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 693216010074 FAD binding pocket [chemical binding]; other site 693216010075 FAD binding motif [chemical binding]; other site 693216010076 catalytic residues [active] 693216010077 NAD binding pocket [chemical binding]; other site 693216010078 phosphate binding motif [ion binding]; other site 693216010079 beta-alpha-beta structure motif; other site 693216010080 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 693216010081 active site 693216010082 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 693216010083 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 693216010084 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase; Region: TPM; cl01535 693216010085 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 693216010086 putative active site cavity [active] 693216010087 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 693216010088 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 693216010089 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 693216010090 active site turn [active] 693216010091 phosphorylation site [posttranslational modification] 693216010092 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 693216010093 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 693216010094 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 693216010095 putative active site [active] 693216010096 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693216010097 Male sterility protein; Region: NAD_binding_4; pfam07993 693216010098 NAD(P) binding site [chemical binding]; other site 693216010099 active site 693216010100 enolase; Provisional; Region: eno; PRK00077 693216010101 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 693216010102 dimer interface [polypeptide binding]; other site 693216010103 metal binding site [ion binding]; metal-binding site 693216010104 substrate binding pocket [chemical binding]; other site 693216010105 CTP synthetase; Validated; Region: pyrG; PRK05380 693216010106 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 693216010107 Catalytic site [active] 693216010108 active site 693216010109 UTP binding site [chemical binding]; other site 693216010110 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 693216010111 active site 693216010112 putative oxyanion hole; other site 693216010113 catalytic triad [active] 693216010114 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 693216010115 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 693216010116 homodimer interface [polypeptide binding]; other site 693216010117 metal binding site [ion binding]; metal-binding site 693216010118 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 693216010119 homodimer interface [polypeptide binding]; other site 693216010120 active site 693216010121 putative chemical substrate binding site [chemical binding]; other site 693216010122 metal binding site [ion binding]; metal-binding site 693216010123 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 693216010124 HD domain; Region: HD_4; pfam13328 693216010125 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 693216010126 synthetase active site [active] 693216010127 NTP binding site [chemical binding]; other site 693216010128 metal binding site [ion binding]; metal-binding site 693216010129 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 693216010130 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 693216010131 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 693216010132 TRAM domain; Region: TRAM; pfam01938 693216010133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693216010134 S-adenosylmethionine binding site [chemical binding]; other site 693216010135 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 693216010136 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 693216010137 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693216010138 dimerization interface [polypeptide binding]; other site 693216010139 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693216010140 dimer interface [polypeptide binding]; other site 693216010141 phosphorylation site [posttranslational modification] 693216010142 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693216010143 ATP binding site [chemical binding]; other site 693216010144 Mg2+ binding site [ion binding]; other site 693216010145 G-X-G motif; other site 693216010146 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 693216010147 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693216010148 active site 693216010149 phosphorylation site [posttranslational modification] 693216010150 intermolecular recognition site; other site 693216010151 dimerization interface [polypeptide binding]; other site 693216010152 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 693216010153 putative binding surface; other site 693216010154 active site 693216010155 flavodoxin; Provisional; Region: PRK08105 693216010156 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 693216010157 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 693216010158 probable active site [active] 693216010159 tRNA pseudouridine synthase C; Region: DUF446; cl01187 693216010160 SecY interacting protein Syd; Provisional; Region: PRK04968 693216010161 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 693216010162 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 693216010163 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 693216010164 Domain of unknown function (DUF4478); Region: DUF4478; pfam14793 693216010165 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 693216010166 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 693216010167 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 693216010168 serine transporter; Region: stp; TIGR00814 693216010169 L-serine dehydratase TdcG; Provisional; Region: PRK15040 693216010170 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 693216010171 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 693216010172 flap endonuclease-like protein; Provisional; Region: PRK09482 693216010173 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 693216010174 active site 693216010175 metal binding site 1 [ion binding]; metal-binding site 693216010176 putative 5' ssDNA interaction site; other site 693216010177 metal binding site 3; metal-binding site 693216010178 metal binding site 2 [ion binding]; metal-binding site 693216010179 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 693216010180 putative DNA binding site [nucleotide binding]; other site 693216010181 putative metal binding site [ion binding]; other site 693216010182 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 693216010183 FtsJ-like methyltransferase; Region: FtsJ; cl17430 693216010184 hypothetical protein; Provisional; Region: PRK10873 693216010185 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 693216010186 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216010187 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 693216010188 dimerization interface [polypeptide binding]; other site 693216010189 substrate binding pocket [chemical binding]; other site 693216010190 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 693216010191 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 693216010192 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 693216010193 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693216010194 catalytic residue [active] 693216010195 Fe-S metabolizm associated domain; Region: SufE; cl00951 693216010196 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 693216010197 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 693216010198 putative ATP binding site [chemical binding]; other site 693216010199 putative substrate interface [chemical binding]; other site 693216010200 murein transglycosylase A; Provisional; Region: mltA; PRK11162 693216010201 MltA specific insert domain; Region: MltA; smart00925 693216010202 3D domain; Region: 3D; pfam06725 693216010203 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 693216010204 AMIN domain; Region: AMIN; pfam11741 693216010205 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 693216010206 active site 693216010207 metal binding site [ion binding]; metal-binding site 693216010208 N-acetylglutamate synthase; Validated; Region: PRK05279 693216010209 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 693216010210 putative feedback inhibition sensing region; other site 693216010211 putative nucleotide binding site [chemical binding]; other site 693216010212 putative substrate binding site [chemical binding]; other site 693216010213 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693216010214 Coenzyme A binding pocket [chemical binding]; other site 693216010215 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 693216010216 AAA domain; Region: AAA_30; pfam13604 693216010217 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 693216010218 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 693216010219 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 693216010220 protease3; Provisional; Region: PRK15101 693216010221 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 693216010222 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 693216010223 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 693216010224 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 693216010225 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 693216010226 hypothetical protein; Provisional; Region: PRK10332 693216010227 Protein of unknown function (DUF2509); Region: DUF2509; pfam10713 693216010228 hypothetical protein; Provisional; Region: PRK10557 693216010229 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 693216010230 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 693216010231 hypothetical protein; Provisional; Region: PRK10506 693216010232 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 693216010233 dimerization interface [polypeptide binding]; other site 693216010234 active site 693216010235 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 693216010236 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 693216010237 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 693216010238 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 693216010239 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 693216010240 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 693216010241 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 693216010242 putative active site [active] 693216010243 Ap4A binding site [chemical binding]; other site 693216010244 nudix motif; other site 693216010245 putative metal binding site [ion binding]; other site 693216010246 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 693216010247 putative DNA-binding cleft [nucleotide binding]; other site 693216010248 putative DNA clevage site; other site 693216010249 molecular lever; other site 693216010250 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 693216010251 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 693216010252 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693216010253 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 693216010254 active site 693216010255 catalytic tetrad [active] 693216010256 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216010257 putative substrate translocation pore; other site 693216010258 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 693216010259 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 693216010260 putative acyl-acceptor binding pocket; other site 693216010261 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 693216010262 acyl-activating enzyme (AAE) consensus motif; other site 693216010263 putative AMP binding site [chemical binding]; other site 693216010264 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 693216010265 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693216010266 DNA binding site [nucleotide binding] 693216010267 domain linker motif; other site 693216010268 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 693216010269 dimerization interface (closed form) [polypeptide binding]; other site 693216010270 ligand binding site [chemical binding]; other site 693216010271 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693216010272 Coenzyme A binding pocket [chemical binding]; other site 693216010273 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 693216010274 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693216010275 DNA-binding site [nucleotide binding]; DNA binding site 693216010276 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 693216010277 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 693216010278 active site 693216010279 P-loop; other site 693216010280 phosphorylation site [posttranslational modification] 693216010281 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 693216010282 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 693216010283 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 693216010284 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693216010285 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693216010286 DNA binding site [nucleotide binding] 693216010287 domain linker motif; other site 693216010288 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 693216010289 dimerization interface (closed form) [polypeptide binding]; other site 693216010290 ligand binding site [chemical binding]; other site 693216010291 diaminopimelate decarboxylase; Provisional; Region: PRK11165 693216010292 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 693216010293 active site 693216010294 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693216010295 substrate binding site [chemical binding]; other site 693216010296 catalytic residues [active] 693216010297 dimer interface [polypeptide binding]; other site 693216010298 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 693216010299 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216010300 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693216010301 dimerization interface [polypeptide binding]; other site 693216010302 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 693216010303 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 693216010304 LPS O-antigen length regulator; Provisional; Region: PRK10381 693216010305 Chain length determinant protein; Region: Wzz; pfam02706 693216010306 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 693216010307 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 693216010308 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216010309 dimer interface [polypeptide binding]; other site 693216010310 conserved gate region; other site 693216010311 putative PBP binding loops; other site 693216010312 ABC-ATPase subunit interface; other site 693216010313 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 693216010314 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216010315 dimer interface [polypeptide binding]; other site 693216010316 conserved gate region; other site 693216010317 putative PBP binding loops; other site 693216010318 ABC-ATPase subunit interface; other site 693216010319 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 693216010320 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 693216010321 Walker A/P-loop; other site 693216010322 ATP binding site [chemical binding]; other site 693216010323 Q-loop/lid; other site 693216010324 ABC transporter signature motif; other site 693216010325 Walker B; other site 693216010326 D-loop; other site 693216010327 H-loop/switch region; other site 693216010328 TOBE domain; Region: TOBE; pfam03459 693216010329 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 693216010330 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 693216010331 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 693216010332 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 693216010333 NADP binding site [chemical binding]; other site 693216010334 homodimer interface [polypeptide binding]; other site 693216010335 active site 693216010336 Oligogalacturonate lyase; Region: Pectate_lyase22; pfam14583 693216010337 Sigma NS protein; Region: PolyG_pol; pfam01518 693216010338 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 693216010339 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 693216010340 putative acyltransferase; Provisional; Region: PRK05790 693216010341 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 693216010342 dimer interface [polypeptide binding]; other site 693216010343 active site 693216010344 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 693216010345 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 693216010346 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 693216010347 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 693216010348 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 693216010349 trimethylamine-N-oxide reductase TorA; Region: torA; TIGR02164 693216010350 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 693216010351 Protein of unknown function (DUF3277); Region: DUF3277; pfam11681 693216010352 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 693216010353 Bacteriophage Rz lysis protein; Region: Phage_lysis; pfam03245 693216010354 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 693216010355 catalytic residues [active] 693216010356 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693216010357 non-specific DNA binding site [nucleotide binding]; other site 693216010358 Predicted transcriptional regulator [Transcription]; Region: COG2932 693216010359 salt bridge; other site 693216010360 sequence-specific DNA binding site [nucleotide binding]; other site 693216010361 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 693216010362 Catalytic site [active] 693216010363 NIPSNAP; Region: NIPSNAP; pfam07978 693216010364 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 693216010365 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693216010366 Peptidase family M23; Region: Peptidase_M23; pfam01551 693216010367 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 693216010368 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 693216010369 dimer interface [polypeptide binding]; other site 693216010370 putative anticodon binding site; other site 693216010371 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 693216010372 motif 1; other site 693216010373 active site 693216010374 motif 2; other site 693216010375 motif 3; other site 693216010376 peptide chain release factor 2; Validated; Region: prfB; PRK00578 693216010377 This domain is found in peptide chain release factors; Region: PCRF; smart00937 693216010378 RF-1 domain; Region: RF-1; pfam00472 693216010379 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 693216010380 DHH family; Region: DHH; pfam01368 693216010381 DHHA1 domain; Region: DHHA1; pfam02272 693216010382 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 693216010383 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 693216010384 dimerization domain [polypeptide binding]; other site 693216010385 dimer interface [polypeptide binding]; other site 693216010386 catalytic residues [active] 693216010387 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 693216010388 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 693216010389 active site 693216010390 Int/Topo IB signature motif; other site 693216010391 flavodoxin FldB; Provisional; Region: PRK12359 693216010392 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 693216010393 hypothetical protein; Provisional; Region: PRK10878 693216010394 putative global regulator; Reviewed; Region: PRK09559 693216010395 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 693216010396 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 693216010397 hemolysin; Provisional; Region: PRK15087 693216010398 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 693216010399 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 693216010400 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 693216010401 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 693216010402 putative active site [active] 693216010403 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 693216010404 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 693216010405 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 693216010406 classical (c) SDRs; Region: SDR_c; cd05233 693216010407 NAD(P) binding site [chemical binding]; other site 693216010408 active site 693216010409 glycine dehydrogenase; Provisional; Region: PRK05367 693216010410 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 693216010411 tetramer interface [polypeptide binding]; other site 693216010412 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216010413 catalytic residue [active] 693216010414 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 693216010415 tetramer interface [polypeptide binding]; other site 693216010416 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216010417 catalytic residue [active] 693216010418 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 693216010419 lipoyl attachment site [posttranslational modification]; other site 693216010420 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 693216010421 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 693216010422 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 693216010423 oxidoreductase; Provisional; Region: PRK08013 693216010424 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 693216010425 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 693216010426 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 693216010427 proline aminopeptidase P II; Provisional; Region: PRK10879 693216010428 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 693216010429 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 693216010430 active site 693216010431 hypothetical protein; Reviewed; Region: PRK01736 693216010432 Z-ring-associated protein; Provisional; Region: PRK10972 693216010433 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 693216010434 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 693216010435 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 693216010436 ligand binding site [chemical binding]; other site 693216010437 NAD binding site [chemical binding]; other site 693216010438 tetramer interface [polypeptide binding]; other site 693216010439 catalytic site [active] 693216010440 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 693216010441 L-serine binding site [chemical binding]; other site 693216010442 ACT domain interface; other site 693216010443 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 693216010444 tetramer (dimer of dimers) interface [polypeptide binding]; other site 693216010445 active site 693216010446 dimer interface [polypeptide binding]; other site 693216010447 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 693216010448 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216010449 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 693216010450 putative dimerization interface [polypeptide binding]; other site 693216010451 oxidative stress defense protein; Provisional; Region: PRK11087 693216010452 arginine exporter protein; Provisional; Region: PRK09304 693216010453 mechanosensitive channel MscS; Provisional; Region: PRK10334 693216010454 Mechanosensitive ion channel; Region: MS_channel; pfam00924 693216010455 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 693216010456 active site 693216010457 intersubunit interface [polypeptide binding]; other site 693216010458 zinc binding site [ion binding]; other site 693216010459 Na+ binding site [ion binding]; other site 693216010460 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 693216010461 substrate binding site [chemical binding]; other site 693216010462 hinge regions; other site 693216010463 ADP binding site [chemical binding]; other site 693216010464 catalytic site [active] 693216010465 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 693216010466 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 693216010467 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 693216010468 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 693216010469 transketolase; Reviewed; Region: PRK12753 693216010470 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 693216010471 TPP-binding site [chemical binding]; other site 693216010472 dimer interface [polypeptide binding]; other site 693216010473 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 693216010474 PYR/PP interface [polypeptide binding]; other site 693216010475 dimer interface [polypeptide binding]; other site 693216010476 TPP binding site [chemical binding]; other site 693216010477 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 693216010478 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 693216010479 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 693216010480 oligomer interface [polypeptide binding]; other site 693216010481 putative active site [active] 693216010482 Mn binding site [ion binding]; other site 693216010483 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 693216010484 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 693216010485 dimer interface [polypeptide binding]; other site 693216010486 active site 693216010487 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693216010488 catalytic residues [active] 693216010489 substrate binding site [chemical binding]; other site 693216010490 S-adenosylmethionine synthetase; Validated; Region: PRK05250 693216010491 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 693216010492 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 693216010493 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 693216010494 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 693216010495 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216010496 putative substrate translocation pore; other site 693216010497 hypothetical protein; Provisional; Region: PRK04860 693216010498 DNA-specific endonuclease I; Provisional; Region: PRK15137 693216010499 RNA methyltransferase, RsmE family; Region: TIGR00046 693216010500 glutathione synthetase; Provisional; Region: PRK05246 693216010501 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 693216010502 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 693216010503 hypothetical protein; Validated; Region: PRK00228 693216010504 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 693216010505 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 693216010506 Transcriptional regulator [Transcription]; Region: IclR; COG1414 693216010507 Bacterial transcriptional regulator; Region: IclR; pfam01614 693216010508 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 693216010509 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 693216010510 Walker A motif; other site 693216010511 ATP binding site [chemical binding]; other site 693216010512 Walker B motif; other site 693216010513 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 693216010514 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693216010515 catalytic residue [active] 693216010516 YGGT family; Region: YGGT; pfam02325 693216010517 Predicted integral membrane protein [Function unknown]; Region: COG0762 693216010518 hypothetical protein; Validated; Region: PRK05090 693216010519 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 693216010520 active site 693216010521 dimerization interface [polypeptide binding]; other site 693216010522 HemN family oxidoreductase; Provisional; Region: PRK05660 693216010523 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693216010524 FeS/SAM binding site; other site 693216010525 HemN C-terminal domain; Region: HemN_C; pfam06969 693216010526 FtsI repressor; Provisional; Region: PRK10883 693216010527 Cupredoxin superfamily; Region: Cupredoxin; cl19115 693216010528 The second Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_2_CueO_FtsP; cd13867 693216010529 Domain 1 interface [polypeptide binding]; other site 693216010530 Domain 3 interface [polypeptide binding]; other site 693216010531 The third Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_3_CueO_FtsP; cd13890 693216010532 Domain 2 interface [polypeptide binding]; other site 693216010533 Domain 1 interface [polypeptide binding]; other site 693216010534 Type 1 (T1) Cu binding site [ion binding]; other site 693216010535 trinuclear Cu binding site [ion binding]; other site 693216010536 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 693216010537 putative acyl-acceptor binding pocket; other site 693216010538 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 693216010539 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 693216010540 CAP-like domain; other site 693216010541 active site 693216010542 primary dimer interface [polypeptide binding]; other site 693216010543 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 693216010544 Uncharacterized conserved protein [Function unknown]; Region: COG1359 693216010545 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 693216010546 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 693216010547 heme binding site [chemical binding]; other site 693216010548 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 693216010549 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693216010550 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216010551 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693216010552 dimerization interface [polypeptide binding]; other site 693216010553 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 693216010554 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 693216010555 he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946 693216010556 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 693216010557 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 693216010558 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 693216010559 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 693216010560 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 693216010561 Coenzyme A transferase; Region: CoA_trans; cl17247 693216010562 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 693216010563 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693216010564 ATP binding site [chemical binding]; other site 693216010565 Mg2+ binding site [ion binding]; other site 693216010566 G-X-G motif; other site 693216010567 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 693216010568 anchoring element; other site 693216010569 dimer interface [polypeptide binding]; other site 693216010570 ATP binding site [chemical binding]; other site 693216010571 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 693216010572 active site 693216010573 metal binding site [ion binding]; metal-binding site 693216010574 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 693216010575 esterase YqiA; Provisional; Region: PRK11071 693216010576 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 693216010577 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 693216010578 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 693216010579 active site 693216010580 metal binding site [ion binding]; metal-binding site 693216010581 hexamer interface [polypeptide binding]; other site 693216010582 putative dehydrogenase; Provisional; Region: PRK11039 693216010583 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 693216010584 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 693216010585 dimer interface [polypeptide binding]; other site 693216010586 ADP-ribose binding site [chemical binding]; other site 693216010587 active site 693216010588 nudix motif; other site 693216010589 metal binding site [ion binding]; metal-binding site 693216010590 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 693216010591 Outer membrane efflux protein; Region: OEP; pfam02321 693216010592 Outer membrane efflux protein; Region: OEP; pfam02321 693216010593 hypothetical protein; Provisional; Region: PRK11653 693216010594 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 693216010595 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 693216010596 putative active site [active] 693216010597 metal binding site [ion binding]; metal-binding site 693216010598 zinc transporter ZupT; Provisional; Region: PRK04201 693216010599 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 693216010600 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 693216010601 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 693216010602 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 693216010603 putative ribose interaction site [chemical binding]; other site 693216010604 putative ADP binding site [chemical binding]; other site 693216010605 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 693216010606 active site 693216010607 nucleotide binding site [chemical binding]; other site 693216010608 HIGH motif; other site 693216010609 KMSKS motif; other site 693216010610 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 693216010611 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 693216010612 metal binding triad; other site 693216010613 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 693216010614 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 693216010615 metal binding triad; other site 693216010616 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; cl19627 693216010617 Uncharacterized conserved protein [Function unknown]; Region: COG3025 693216010618 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 693216010619 putative active site [active] 693216010620 putative metal binding residues [ion binding]; other site 693216010621 signature motif; other site 693216010622 putative triphosphate binding site [ion binding]; other site 693216010623 CHAD domain; Region: CHAD; pfam05235 693216010624 SH3 domain-containing protein; Provisional; Region: PRK10884 693216010625 Bacterial SH3 domain homologues; Region: SH3b; smart00287 693216010626 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 693216010627 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 693216010628 active site 693216010629 NTP binding site [chemical binding]; other site 693216010630 metal binding triad [ion binding]; metal-binding site 693216010631 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 693216010632 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693216010633 Zn2+ binding site [ion binding]; other site 693216010634 Mg2+ binding site [ion binding]; other site 693216010635 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 693216010636 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 693216010637 homooctamer interface [polypeptide binding]; other site 693216010638 active site 693216010639 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 693216010640 UGMP family protein; Validated; Region: PRK09604 693216010641 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 693216010642 nucleotide binding site [chemical binding]; other site 693216010643 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 693216010644 DNA primase; Validated; Region: dnaG; PRK05667 693216010645 CHC2 zinc finger; Region: zf-CHC2; pfam01807 693216010646 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 693216010647 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 693216010648 active site 693216010649 metal binding site [ion binding]; metal-binding site 693216010650 interdomain interaction site; other site 693216010651 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 693216010652 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 693216010653 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 693216010654 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 693216010655 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 693216010656 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 693216010657 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693216010658 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 693216010659 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693216010660 DNA binding residues [nucleotide binding] 693216010661 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 693216010662 active site 693216010663 SUMO-1 interface [polypeptide binding]; other site 693216010664 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 693216010665 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 693216010666 substrate binding pocket [chemical binding]; other site 693216010667 chain length determination region; other site 693216010668 substrate-Mg2+ binding site; other site 693216010669 catalytic residues [active] 693216010670 aspartate-rich region 1; other site 693216010671 active site lid residues [active] 693216010672 aspartate-rich region 2; other site 693216010673 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 693216010674 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 693216010675 homotetramer interface [polypeptide binding]; other site 693216010676 FMN binding site [chemical binding]; other site 693216010677 homodimer contacts [polypeptide binding]; other site 693216010678 putative active site [active] 693216010679 putative substrate binding site [chemical binding]; other site 693216010680 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 693216010681 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 693216010682 active site 693216010683 TDP-binding site; other site 693216010684 acceptor substrate-binding pocket; other site 693216010685 homodimer interface [polypeptide binding]; other site 693216010686 lycopene cyclase; Region: lycopene_cycl; TIGR01789 693216010687 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 693216010688 phytoene desaturase; Region: crtI_fam; TIGR02734 693216010689 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 693216010690 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 693216010691 active site lid residues [active] 693216010692 substrate binding pocket [chemical binding]; other site 693216010693 catalytic residues [active] 693216010694 substrate-Mg2+ binding site; other site 693216010695 aspartate-rich region 1; other site 693216010696 aspartate-rich region 2; other site 693216010697 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693216010698 dimerization interface [polypeptide binding]; other site 693216010699 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693216010700 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693216010701 dimer interface [polypeptide binding]; other site 693216010702 putative CheW interface [polypeptide binding]; other site 693216010703 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 693216010704 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 693216010705 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 693216010706 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693216010707 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216010708 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693216010709 dimerization interface [polypeptide binding]; other site 693216010710 carbon starvation protein A; Provisional; Region: PRK15015 693216010711 Carbon starvation protein CstA; Region: CstA; pfam02554 693216010712 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 693216010713 Uncharacterized small protein [Function unknown]; Region: COG2879 693216010714 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 693216010715 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 693216010716 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 693216010717 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 693216010718 hypothetical protein; Provisional; Region: PRK10626 693216010719 hypothetical protein; Provisional; Region: PRK11702 693216010720 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 693216010721 adenine DNA glycosylase; Provisional; Region: PRK10880 693216010722 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 693216010723 minor groove reading motif; other site 693216010724 helix-hairpin-helix signature motif; other site 693216010725 substrate binding pocket [chemical binding]; other site 693216010726 active site 693216010727 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 693216010728 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 693216010729 DNA binding and oxoG recognition site [nucleotide binding] 693216010730 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2924 693216010731 murein transglycosylase C; Provisional; Region: mltC; PRK11671 693216010732 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 693216010733 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693216010734 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693216010735 catalytic residue [active] 693216010736 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 693216010737 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 693216010738 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 693216010739 Coenzyme A transferase; Region: CoA_trans; cl17247 693216010740 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 693216010741 citrate lyase subunit gamma; Provisional; Region: PRK13253 693216010742 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 693216010743 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 693216010744 active site 693216010745 nucleotide binding site [chemical binding]; other site 693216010746 HIGH motif; other site 693216010747 KMSKS motif; other site 693216010748 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 693216010749 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 693216010750 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 693216010751 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 693216010752 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 693216010753 PAS domain; Region: PAS; smart00091 693216010754 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 693216010755 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693216010756 ATP binding site [chemical binding]; other site 693216010757 Mg2+ binding site [ion binding]; other site 693216010758 G-X-G motif; other site 693216010759 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 693216010760 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693216010761 active site 693216010762 phosphorylation site [posttranslational modification] 693216010763 intermolecular recognition site; other site 693216010764 dimerization interface [polypeptide binding]; other site 693216010765 Transcriptional regulator; Region: CitT; pfam12431 693216010766 ornithine decarboxylase; Provisional; Region: PRK13578 693216010767 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 693216010768 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 693216010769 homodimer interface [polypeptide binding]; other site 693216010770 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216010771 catalytic residue [active] 693216010772 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 693216010773 Protein of unknown function (DUF554); Region: DUF554; pfam04474 693216010774 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 693216010775 Peptidase family M23; Region: Peptidase_M23; pfam01551 693216010776 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 693216010777 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 693216010778 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 693216010779 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 693216010780 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 693216010781 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 693216010782 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 693216010783 TT viral orf 1; Region: TT_ORF1; pfam02956 693216010784 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 693216010785 Autotransporter beta-domain; Region: Autotransporter; pfam03797 693216010786 Predicted membrane protein (DUF2238); Region: DUF2238; cl01464 693216010787 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693216010788 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693216010789 DNA binding site [nucleotide binding] 693216010790 domain linker motif; other site 693216010791 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 693216010792 ligand binding site [chemical binding]; other site 693216010793 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 693216010794 active site 693216010795 P-loop; other site 693216010796 phosphorylation site [posttranslational modification] 693216010797 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 693216010798 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 693216010799 methionine cluster; other site 693216010800 active site 693216010801 phosphorylation site [posttranslational modification] 693216010802 metal binding site [ion binding]; metal-binding site 693216010803 maltoporin; Provisional; Region: lamB; PRK09360 693216010804 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693216010805 NlpC/P60 family; Region: NLPC_P60; cl17555 693216010806 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 693216010807 Mechanosensitive ion channel; Region: MS_channel; pfam00924 693216010808 hypothetical protein; Provisional; Region: PRK05208 693216010809 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 693216010810 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 693216010811 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 693216010812 oxidoreductase; Provisional; Region: PRK07985 693216010813 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 693216010814 NAD binding site [chemical binding]; other site 693216010815 metal binding site [ion binding]; metal-binding site 693216010816 active site 693216010817 biopolymer transport protein ExbD; Provisional; Region: PRK11267 693216010818 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 693216010819 biopolymer transport protein ExbB; Provisional; Region: PRK10414 693216010820 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 693216010821 homodimer interface [polypeptide binding]; other site 693216010822 substrate-cofactor binding pocket; other site 693216010823 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216010824 catalytic residue [active] 693216010825 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 693216010826 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 693216010827 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693216010828 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693216010829 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693216010830 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 693216010831 dimer interface [polypeptide binding]; other site 693216010832 active site 693216010833 metal binding site [ion binding]; metal-binding site 693216010834 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693216010835 active site 693216010836 catalytic tetrad [active] 693216010837 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 693216010838 Uncharacterized conserved protein [Function unknown]; Region: COG1359 693216010839 glutaredoxin 2; Provisional; Region: PRK10387 693216010840 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 693216010841 C-terminal domain interface [polypeptide binding]; other site 693216010842 GSH binding site (G-site) [chemical binding]; other site 693216010843 catalytic residues [active] 693216010844 putative dimer interface [polypeptide binding]; other site 693216010845 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 693216010846 N-terminal domain interface [polypeptide binding]; other site 693216010847 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693216010848 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693216010849 trehalose repressor; Provisional; Region: treR; PRK09492 693216010850 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693216010851 DNA binding site [nucleotide binding] 693216010852 domain linker motif; other site 693216010853 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 693216010854 dimerization interface [polypeptide binding]; other site 693216010855 ligand binding site [chemical binding]; other site 693216010856 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 693216010857 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 693216010858 active site turn [active] 693216010859 phosphorylation site [posttranslational modification] 693216010860 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 693216010861 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 693216010862 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 693216010863 Ca binding site [ion binding]; other site 693216010864 active site 693216010865 catalytic site [active] 693216010866 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 693216010867 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 693216010868 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693216010869 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216010870 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693216010871 putative effector binding pocket; other site 693216010872 dimerization interface [polypeptide binding]; other site 693216010873 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 693216010874 ATP cone domain; Region: ATP-cone; pfam03477 693216010875 Class III ribonucleotide reductase; Region: RNR_III; cd01675 693216010876 effector binding site; other site 693216010877 active site 693216010878 Zn binding site [ion binding]; other site 693216010879 glycine loop; other site 693216010880 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; PRK11121 693216010881 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 693216010882 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 693216010883 nucleoside/Zn binding site; other site 693216010884 dimer interface [polypeptide binding]; other site 693216010885 catalytic motif [active] 693216010886 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 693216010887 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216010888 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693216010889 dimerization interface [polypeptide binding]; other site 693216010890 putative transporter; Provisional; Region: PRK03699 693216010891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216010892 putative substrate translocation pore; other site 693216010893 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 693216010894 purine nucleoside phosphorylase; Provisional; Region: PRK08202 693216010895 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 693216010896 cytochrome b562; Provisional; Region: PRK15058 693216010897 peptidase PmbA; Provisional; Region: PRK11040 693216010898 hypothetical protein; Provisional; Region: PRK05255 693216010899 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 693216010900 active site 693216010901 catalytic residues [active] 693216010902 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 693216010903 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 693216010904 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693216010905 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 693216010906 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 693216010907 AMP binding site [chemical binding]; other site 693216010908 metal binding site [ion binding]; metal-binding site 693216010909 active site 693216010910 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 693216010911 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 693216010912 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 693216010913 dimer interface [polypeptide binding]; other site 693216010914 ligand binding site [chemical binding]; other site 693216010915 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693216010916 dimerization interface [polypeptide binding]; other site 693216010917 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693216010918 dimer interface [polypeptide binding]; other site 693216010919 putative CheW interface [polypeptide binding]; other site 693216010920 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693216010921 TM-ABC transporter signature motif; other site 693216010922 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693216010923 TM-ABC transporter signature motif; other site 693216010924 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 693216010925 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693216010926 Walker A/P-loop; other site 693216010927 ATP binding site [chemical binding]; other site 693216010928 Q-loop/lid; other site 693216010929 ABC transporter signature motif; other site 693216010930 Walker B; other site 693216010931 D-loop; other site 693216010932 H-loop/switch region; other site 693216010933 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693216010934 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 693216010935 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 693216010936 putative ligand binding site [chemical binding]; other site 693216010937 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 693216010938 dimer interface [polypeptide binding]; other site 693216010939 substrate binding site [chemical binding]; other site 693216010940 metal binding sites [ion binding]; metal-binding site 693216010941 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693216010942 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693216010943 dimerization interface [polypeptide binding]; other site 693216010944 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 693216010945 dimer interface [polypeptide binding]; other site 693216010946 putative CheW interface [polypeptide binding]; other site 693216010947 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 693216010948 O-Antigen ligase; Region: Wzy_C; pfam04932 693216010949 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 693216010950 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 693216010951 Fimbrial protein; Region: Fimbrial; cl01416 693216010952 Fimbrial protein; Region: Fimbrial; pfam00419 693216010953 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 693216010954 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 693216010955 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 693216010956 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 693216010957 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 693216010958 PapC N-terminal domain; Region: PapC_N; pfam13954 693216010959 Outer membrane usher protein; Region: Usher; pfam00577 693216010960 PapC C-terminal domain; Region: PapC_C; pfam13953 693216010961 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 693216010962 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 693216010963 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 693216010964 putative active site pocket [active] 693216010965 dimerization interface [polypeptide binding]; other site 693216010966 putative catalytic residue [active] 693216010967 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 693216010968 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 693216010969 Family of unknown function (DUF490); Region: DUF490; pfam04357 693216010970 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 693216010971 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 693216010972 Surface antigen; Region: Bac_surface_Ag; pfam01103 693216010973 methionine sulfoxide reductase A; Provisional; Region: PRK00058 693216010974 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 693216010975 Domain of unknown function DUF21; Region: DUF21; pfam01595 693216010976 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 693216010977 Transporter associated domain; Region: CorC_HlyC; smart01091 693216010978 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 693216010979 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; cl17398 693216010980 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 693216010981 active site 693216010982 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 693216010983 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 693216010984 active site 693216010985 metal binding site [ion binding]; metal-binding site 693216010986 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 693216010987 Predicted transcriptional regulators [Transcription]; Region: COG1733 693216010988 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 693216010989 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 693216010990 NADP binding site [chemical binding]; other site 693216010991 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 693216010992 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 693216010993 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 693216010994 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693216010995 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693216010996 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 693216010997 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 693216010998 EamA-like transporter family; Region: EamA; pfam00892 693216010999 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 693216011000 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 693216011001 dimer interface [polypeptide binding]; other site 693216011002 ligand binding site [chemical binding]; other site 693216011003 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693216011004 dimerization interface [polypeptide binding]; other site 693216011005 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693216011006 dimer interface [polypeptide binding]; other site 693216011007 putative CheW interface [polypeptide binding]; other site 693216011008 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 693216011009 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 693216011010 Hemerythrin-like domain; Region: Hr-like; cd12108 693216011011 Fe binding site [ion binding]; other site 693216011012 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 693216011013 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 693216011014 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 693216011015 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 693216011016 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 693216011017 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 693216011018 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 693216011019 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 693216011020 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 693216011021 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 693216011022 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 693216011023 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 693216011024 dimer interface [polypeptide binding]; other site 693216011025 ssDNA binding site [nucleotide binding]; other site 693216011026 tetramer (dimer of dimers) interface [polypeptide binding]; other site 693216011027 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 693216011028 esterase; Provisional; Region: PRK10566 693216011029 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 693216011030 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 693216011031 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 693216011032 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693216011033 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693216011034 dimerization interface [polypeptide binding]; other site 693216011035 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693216011036 dimer interface [polypeptide binding]; other site 693216011037 putative CheW interface [polypeptide binding]; other site 693216011038 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 693216011039 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 693216011040 active site 693216011041 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 693216011042 Protein of unknown function (DUF1190); Region: DUF1190; cl10031 693216011043 Predicted membrane protein [Function unknown]; Region: COG3766 693216011044 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 693216011045 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 693216011046 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 693216011047 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 693216011048 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 693216011049 exoribonuclease R; Provisional; Region: PRK11642 693216011050 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 693216011051 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 693216011052 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 693216011053 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 693216011054 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 693216011055 RNA binding site [nucleotide binding]; other site 693216011056 transcriptional repressor NsrR; Provisional; Region: PRK11014 693216011057 Rrf2 family protein; Region: rrf2_super; TIGR00738 693216011058 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 693216011059 GDP-binding site [chemical binding]; other site 693216011060 ACT binding site; other site 693216011061 IMP binding site; other site 693216011062 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 693216011063 HflC protein; Region: hflC; TIGR01932 693216011064 High frequency of lysogenization C (HflC) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflC; cd03405 693216011065 FtsH protease regulator HflK; Provisional; Region: PRK10930 693216011066 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 693216011067 High frequency of lysogenization K (HflK) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflK; cd03404 693216011068 GTPase HflX; Provisional; Region: PRK11058 693216011069 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 693216011070 HflX GTPase family; Region: HflX; cd01878 693216011071 G1 box; other site 693216011072 GTP/Mg2+ binding site [chemical binding]; other site 693216011073 Switch I region; other site 693216011074 G2 box; other site 693216011075 G3 box; other site 693216011076 Switch II region; other site 693216011077 G4 box; other site 693216011078 G5 box; other site 693216011079 bacterial Hfq-like; Region: Hfq; cd01716 693216011080 hexamer interface [polypeptide binding]; other site 693216011081 Sm1 motif; other site 693216011082 RNA binding site [nucleotide binding]; other site 693216011083 Sm2 motif; other site 693216011084 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 693216011085 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 693216011086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693216011087 ATP binding site [chemical binding]; other site 693216011088 Mg2+ binding site [ion binding]; other site 693216011089 G-X-G motif; other site 693216011090 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 693216011091 ATP binding site [chemical binding]; other site 693216011092 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 693216011093 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 693216011094 AMIN domain; Region: AMIN; pfam11741 693216011095 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 693216011096 active site 693216011097 metal binding site [ion binding]; metal-binding site 693216011098 ADP-binding protein; Provisional; Region: PRK10646 693216011099 putative carbohydrate kinase; Provisional; Region: PRK10565 693216011100 Uncharacterized conserved protein [Function unknown]; Region: COG0062 693216011101 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 693216011102 putative substrate binding site [chemical binding]; other site 693216011103 putative ATP binding site [chemical binding]; other site 693216011104 epoxyqueuosine reductase; Region: TIGR00276 693216011105 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 693216011106 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 693216011107 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 693216011108 catalytic site [active] 693216011109 putative active site [active] 693216011110 putative substrate binding site [chemical binding]; other site 693216011111 dimer interface [polypeptide binding]; other site 693216011112 GTPase RsgA; Reviewed; Region: PRK12288 693216011113 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 693216011114 RNA binding site [nucleotide binding]; other site 693216011115 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 693216011116 GTPase/Zn-binding domain interface [polypeptide binding]; other site 693216011117 GTP/Mg2+ binding site [chemical binding]; other site 693216011118 G4 box; other site 693216011119 G5 box; other site 693216011120 G1 box; other site 693216011121 Switch I region; other site 693216011122 G2 box; other site 693216011123 G3 box; other site 693216011124 Switch II region; other site 693216011125 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 693216011126 putative mechanosensitive channel protein; Provisional; Region: PRK10929 693216011127 Bacterial type III secretion protein (HrpB7); Region: HrpB7; cl09720 693216011128 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 693216011129 Mechanosensitive ion channel; Region: MS_channel; pfam00924 693216011130 poxB regulator PoxA; Provisional; Region: PRK09350 693216011131 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 693216011132 motif 1; other site 693216011133 dimer interface [polypeptide binding]; other site 693216011134 active site 693216011135 motif 2; other site 693216011136 motif 3; other site 693216011137 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 693216011138 L-aspartate oxidase; Provisional; Region: PRK06175 693216011139 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 693216011140 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 693216011141 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 693216011142 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 693216011143 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 693216011144 D-subunit interface [polypeptide binding]; other site 693216011145 Iron-sulfur protein interface; other site 693216011146 proximal quinone binding site [chemical binding]; other site 693216011147 distal quinone binding site [chemical binding]; other site 693216011148 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 693216011149 Iron-sulfur protein interface; other site 693216011150 proximal quinone binding site [chemical binding]; other site 693216011151 C-subunit interface; other site 693216011152 distal quinone binding site; other site 693216011153 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 693216011154 multidrug efflux system protein; Provisional; Region: PRK11431 693216011155 Type IV pilus assembly protein PilM; Region: PilM_2; pfam11104 693216011156 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693216011157 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693216011158 DNA binding residues [nucleotide binding] 693216011159 dimerization interface [polypeptide binding]; other site 693216011160 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 693216011161 Entericidin EcnA/B family; Region: Entericidin; cl02322 693216011162 elongation factor P; Validated; Region: PRK00529 693216011163 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 693216011164 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 693216011165 RNA binding site [nucleotide binding]; other site 693216011166 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 693216011167 RNA binding site [nucleotide binding]; other site 693216011168 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 693216011169 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693216011170 FeS/SAM binding site; other site 693216011171 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 693216011172 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 693216011173 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 693216011174 ring oligomerisation interface [polypeptide binding]; other site 693216011175 ATP/Mg binding site [chemical binding]; other site 693216011176 stacking interactions; other site 693216011177 hinge regions; other site 693216011178 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 693216011179 oligomerisation interface [polypeptide binding]; other site 693216011180 mobile loop; other site 693216011181 roof hairpin; other site 693216011182 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 693216011183 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 693216011184 Aspartase; Region: Aspartase; cd01357 693216011185 active sites [active] 693216011186 tetramer interface [polypeptide binding]; other site 693216011187 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 693216011188 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 693216011189 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 693216011190 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 693216011191 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 693216011192 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 693216011193 DsbD alpha interface [polypeptide binding]; other site 693216011194 catalytic residues [active] 693216011195 putative transcriptional regulator; Provisional; Region: PRK11640 693216011196 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 693216011197 putative S-transferase; Provisional; Region: PRK11752 693216011198 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 693216011199 C-terminal domain interface [polypeptide binding]; other site 693216011200 GSH binding site (G-site) [chemical binding]; other site 693216011201 dimer interface [polypeptide binding]; other site 693216011202 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 693216011203 dimer interface [polypeptide binding]; other site 693216011204 N-terminal domain interface [polypeptide binding]; other site 693216011205 active site 693216011206 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 693216011207 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 693216011208 YjcZ-like protein; Region: YjcZ; pfam13990 693216011209 hypothetical protein; Provisional; Region: PRK09866 693216011210 G1 box; other site 693216011211 GTP/Mg2+ binding site [chemical binding]; other site 693216011212 G2 box; other site 693216011213 Switch I region; other site 693216011214 G3 box; other site 693216011215 Switch II region; other site 693216011216 G4 box; other site 693216011217 G5 box; other site 693216011218 hypothetical protein; Provisional; Region: PRK10220 693216011219 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 693216011220 PhnA protein; Region: PhnA; pfam03831 693216011221 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 693216011222 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 693216011223 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693216011224 ATP binding site [chemical binding]; other site 693216011225 Mg2+ binding site [ion binding]; other site 693216011226 G-X-G motif; other site 693216011227 Hsp90 protein; Region: HSP90; pfam00183 693216011228 Hok/gef family; Region: HOK_GEF; pfam01848 693216011229 Hok/gef family; Region: HOK_GEF; pfam01848 693216011230 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 693216011231 acetyl-CoA synthetase; Provisional; Region: PRK00174 693216011232 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 693216011233 active site 693216011234 CoA binding site [chemical binding]; other site 693216011235 acyl-activating enzyme (AAE) consensus motif; other site 693216011236 AMP binding site [chemical binding]; other site 693216011237 acetate binding site [chemical binding]; other site 693216011238 Predicted membrane protein [Function unknown]; Region: COG3162 693216011239 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 693216011240 Na binding site [ion binding]; other site 693216011241 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 693216011242 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693216011243 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 693216011244 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 693216011245 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 693216011246 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 693216011247 Sulfate transporter family; Region: Sulfate_transp; cl19250 693216011248 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 693216011249 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 693216011250 putative C-terminal domain interface [polypeptide binding]; other site 693216011251 putative GSH binding site (G-site) [chemical binding]; other site 693216011252 putative dimer interface [polypeptide binding]; other site 693216011253 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 693216011254 putative N-terminal domain interface [polypeptide binding]; other site 693216011255 putative dimer interface [polypeptide binding]; other site 693216011256 putative substrate binding pocket (H-site) [chemical binding]; other site 693216011257 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 693216011258 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 693216011259 DNA binding residues [nucleotide binding] 693216011260 dimer interface [polypeptide binding]; other site 693216011261 [2Fe-2S] cluster binding site [ion binding]; other site 693216011262 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 693216011263 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693216011264 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 693216011265 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 693216011266 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693216011267 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693216011268 metal binding site [ion binding]; metal-binding site 693216011269 active site 693216011270 I-site; other site 693216011271 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 693216011272 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 693216011273 dimer interface [polypeptide binding]; other site 693216011274 ssDNA binding site [nucleotide binding]; other site 693216011275 tetramer (dimer of dimers) interface [polypeptide binding]; other site 693216011276 putative single-stranded DNA-binding protein; Region: PHA01740 693216011277 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 693216011278 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 693216011279 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 693216011280 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693216011281 Walker A/P-loop; other site 693216011282 ATP binding site [chemical binding]; other site 693216011283 Q-loop/lid; other site 693216011284 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693216011285 ABC transporter signature motif; other site 693216011286 Walker B; other site 693216011287 D-loop; other site 693216011288 H-loop/switch region; other site 693216011289 aspartate kinase III; Validated; Region: PRK09084 693216011290 haemagglutination activity domain; Region: Haemagg_act; pfam05860 693216011291 Procyclic acidic repetitive protein (PARP); Region: Trypan_PARP; pfam05887 693216011292 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 693216011293 Uncharacterized conserved protein [Function unknown]; Region: COG0432 693216011294 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 693216011295 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 693216011296 Autotransporter beta-domain; Region: Autotransporter; cl17461 693216011297 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 693216011298 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693216011299 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216011300 homodimer interface [polypeptide binding]; other site 693216011301 catalytic residue [active] 693216011302 alanine racemase; Reviewed; Region: alr; PRK00053 693216011303 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 693216011304 active site 693216011305 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693216011306 substrate binding site [chemical binding]; other site 693216011307 catalytic residues [active] 693216011308 dimer interface [polypeptide binding]; other site 693216011309 replicative DNA helicase; Provisional; Region: PRK08006 693216011310 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 693216011311 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 693216011312 Walker A motif; other site 693216011313 ATP binding site [chemical binding]; other site 693216011314 Walker B motif; other site 693216011315 DNA binding loops [nucleotide binding] 693216011316 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 693216011317 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 693216011318 NADP binding site [chemical binding]; other site 693216011319 dimer interface [polypeptide binding]; other site 693216011320 phage shock protein G; Reviewed; Region: pspG; PRK09459 693216011321 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 693216011322 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 693216011323 FMN binding site [chemical binding]; other site 693216011324 active site 693216011325 catalytic residues [active] 693216011326 substrate binding site [chemical binding]; other site 693216011327 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 693216011328 Cupin domain; Region: Cupin_2; cl17218 693216011329 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 693216011330 metal binding site 2 [ion binding]; metal-binding site 693216011331 putative DNA binding helix; other site 693216011332 metal binding site 1 [ion binding]; metal-binding site 693216011333 dimer interface [polypeptide binding]; other site 693216011334 structural Zn2+ binding site [ion binding]; other site 693216011335 hypothetical protein; Provisional; Region: PRK10428 693216011336 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 693216011337 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 693216011338 LexA repressor; Validated; Region: PRK00215 693216011339 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 693216011340 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 693216011341 Catalytic site [active] 693216011342 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 693216011343 Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937 693216011344 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 693216011345 putative acyl-acceptor binding pocket; other site 693216011346 4-Hydroxybenzoate polyprenyltransferase; Region: PT_UbiA_COQ2; cd13959 693216011347 putative active site [active] 693216011348 maltose regulon periplasmic protein; Provisional; Region: PRK10564 693216011349 maltoporin; Provisional; Region: lamB; PRK09360 693216011350 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 693216011351 trimer interface; other site 693216011352 sugar binding site [chemical binding]; other site 693216011353 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 693216011354 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 693216011355 Walker A/P-loop; other site 693216011356 ATP binding site [chemical binding]; other site 693216011357 Q-loop/lid; other site 693216011358 ABC transporter signature motif; other site 693216011359 Walker B; other site 693216011360 D-loop; other site 693216011361 H-loop/switch region; other site 693216011362 TOBE domain; Region: TOBE_2; pfam08402 693216011363 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 693216011364 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 693216011365 maltose transporter membrane protein; Provisional; Region: malF; PRK10999 693216011366 Maltose transport system permease protein MalF P2 domain; Region: MalF_P2; pfam14785 693216011367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216011368 dimer interface [polypeptide binding]; other site 693216011369 conserved gate region; other site 693216011370 putative PBP binding loops; other site 693216011371 ABC-ATPase subunit interface; other site 693216011372 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 693216011373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216011374 dimer interface [polypeptide binding]; other site 693216011375 conserved gate region; other site 693216011376 putative PBP binding loops; other site 693216011377 ABC-ATPase subunit interface; other site 693216011378 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 693216011379 putative trimer interface [polypeptide binding]; other site 693216011380 putative active site [active] 693216011381 putative substrate binding site [chemical binding]; other site 693216011382 putative CoA binding site [chemical binding]; other site 693216011383 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 693216011384 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 693216011385 Group 4 capsule polysaccharide formation lipoprotein gfcB; Region: Cap_synth_GfcB; pfam11102 693216011386 Exopolysaccharide production protein YjbE; Region: YjbE; pfam11106 693216011387 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 693216011388 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 693216011389 active site 693216011390 dimer interface [polypeptide binding]; other site 693216011391 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 693216011392 dimer interface [polypeptide binding]; other site 693216011393 active site 693216011394 aspartate kinase III; Validated; Region: PRK09084 693216011395 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 693216011396 nucleotide binding site [chemical binding]; other site 693216011397 substrate binding site [chemical binding]; other site 693216011398 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 693216011399 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 693216011400 dimer interface [polypeptide binding]; other site 693216011401 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 693216011402 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 693216011403 tRNA-splicing ligase RtcB; Region: RtcB; pfam01139 693216011404 Uncharacterized prokaryotic subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_eoslipins_u2; cd13438 693216011405 prohibitin homologues; Region: PHB; smart00244 693216011406 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 693216011407 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 693216011408 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693216011409 Walker A motif; other site 693216011410 ATP binding site [chemical binding]; other site 693216011411 Walker B motif; other site 693216011412 arginine finger; other site 693216011413 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 693216011414 hypothetical protein; Provisional; Region: PRK10515 693216011415 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693216011416 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693216011417 non-specific DNA binding site [nucleotide binding]; other site 693216011418 salt bridge; other site 693216011419 sequence-specific DNA binding site [nucleotide binding]; other site 693216011420 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 693216011421 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 693216011422 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 693216011423 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 693216011424 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 693216011425 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 693216011426 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 693216011427 substrate binding pocket [chemical binding]; other site 693216011428 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 693216011429 B12 binding site [chemical binding]; other site 693216011430 cobalt ligand [ion binding]; other site 693216011431 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 693216011432 transcriptional repressor IclR; Provisional; Region: PRK11569 693216011433 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 693216011434 Bacterial transcriptional regulator; Region: IclR; pfam01614 693216011435 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 693216011436 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 693216011437 tetramer interface [polypeptide binding]; other site 693216011438 active site 693216011439 Mg2+/Mn2+ binding site [ion binding]; other site 693216011440 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 693216011441 active site 693216011442 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 693216011443 proposed active site lysine [active] 693216011444 conserved cys residue [active] 693216011445 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 693216011446 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 693216011447 trimer interface [polypeptide binding]; other site 693216011448 putative metal binding site [ion binding]; other site 693216011449 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 693216011450 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 693216011451 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 693216011452 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 693216011453 shikimate binding site; other site 693216011454 NAD(P) binding site [chemical binding]; other site 693216011455 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 693216011456 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 693216011457 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 693216011458 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 693216011459 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 693216011460 hypothetical protein; Validated; Region: PRK03430 693216011461 hypothetical protein; Provisional; Region: PRK10736 693216011462 DNA protecting protein DprA; Region: dprA; TIGR00732 693216011463 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 693216011464 active site 693216011465 catalytic residues [active] 693216011466 metal binding site [ion binding]; metal-binding site 693216011467 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 693216011468 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 693216011469 putative active site [active] 693216011470 substrate binding site [chemical binding]; other site 693216011471 putative cosubstrate binding site; other site 693216011472 catalytic site [active] 693216011473 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 693216011474 substrate binding site [chemical binding]; other site 693216011475 16S rRNA methyltransferase B; Provisional; Region: PRK10901 693216011476 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 693216011477 putative RNA binding site [nucleotide binding]; other site 693216011478 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693216011479 S-adenosylmethionine binding site [chemical binding]; other site 693216011480 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 693216011481 TrkA-N domain; Region: TrkA_N; pfam02254 693216011482 TrkA-C domain; Region: TrkA_C; pfam02080 693216011483 TrkA-N domain; Region: TrkA_N; pfam02254 693216011484 TrkA-C domain; Region: TrkA_C; pfam02080 693216011485 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 693216011486 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 693216011487 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 693216011488 DNA binding residues [nucleotide binding] 693216011489 dimer interface [polypeptide binding]; other site 693216011490 metal binding site [ion binding]; metal-binding site 693216011491 hypothetical protein; Provisional; Region: PRK10203 693216011492 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 693216011493 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 693216011494 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 693216011495 alphaNTD homodimer interface [polypeptide binding]; other site 693216011496 alphaNTD - beta interaction site [polypeptide binding]; other site 693216011497 alphaNTD - beta' interaction site [polypeptide binding]; other site 693216011498 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 693216011499 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 693216011500 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 693216011501 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693216011502 RNA binding surface [nucleotide binding]; other site 693216011503 30S ribosomal protein S11; Validated; Region: PRK05309 693216011504 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 693216011505 30S ribosomal protein S13; Region: bact_S13; TIGR03631 693216011506 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 693216011507 SecY translocase; Region: SecY; pfam00344 693216011508 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 693216011509 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 693216011510 23S rRNA binding site [nucleotide binding]; other site 693216011511 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 693216011512 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 693216011513 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 693216011514 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 693216011515 23S rRNA interface [nucleotide binding]; other site 693216011516 5S rRNA interface [nucleotide binding]; other site 693216011517 L27 interface [polypeptide binding]; other site 693216011518 L5 interface [polypeptide binding]; other site 693216011519 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 693216011520 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 693216011521 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 693216011522 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 693216011523 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 693216011524 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 693216011525 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 693216011526 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 693216011527 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 693216011528 RNA binding site [nucleotide binding]; other site 693216011529 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 693216011530 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 693216011531 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 693216011532 23S rRNA interface [nucleotide binding]; other site 693216011533 putative translocon interaction site; other site 693216011534 signal recognition particle (SRP54) interaction site; other site 693216011535 L23 interface [polypeptide binding]; other site 693216011536 trigger factor interaction site; other site 693216011537 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 693216011538 23S rRNA interface [nucleotide binding]; other site 693216011539 5S rRNA interface [nucleotide binding]; other site 693216011540 putative antibiotic binding site [chemical binding]; other site 693216011541 L25 interface [polypeptide binding]; other site 693216011542 L27 interface [polypeptide binding]; other site 693216011543 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 693216011544 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 693216011545 G-X-X-G motif; other site 693216011546 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 693216011547 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 693216011548 protein-rRNA interface [nucleotide binding]; other site 693216011549 putative translocon binding site; other site 693216011550 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 693216011551 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 693216011552 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 693216011553 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 693216011554 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 693216011555 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 693216011556 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 693216011557 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 693216011558 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 693216011559 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 693216011560 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 693216011561 Ferritin-like domain; Region: Ferritin; pfam00210 693216011562 heme binding site [chemical binding]; other site 693216011563 ferroxidase pore; other site 693216011564 ferroxidase diiron center [ion binding]; other site 693216011565 elongation factor Tu; Reviewed; Region: PRK00049 693216011566 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 693216011567 G1 box; other site 693216011568 GEF interaction site [polypeptide binding]; other site 693216011569 GTP/Mg2+ binding site [chemical binding]; other site 693216011570 Switch I region; other site 693216011571 G2 box; other site 693216011572 G3 box; other site 693216011573 Switch II region; other site 693216011574 G4 box; other site 693216011575 G5 box; other site 693216011576 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 693216011577 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 693216011578 Antibiotic Binding Site [chemical binding]; other site 693216011579 elongation factor G; Reviewed; Region: PRK00007 693216011580 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 693216011581 G1 box; other site 693216011582 putative GEF interaction site [polypeptide binding]; other site 693216011583 GTP/Mg2+ binding site [chemical binding]; other site 693216011584 Switch I region; other site 693216011585 G2 box; other site 693216011586 G3 box; other site 693216011587 Switch II region; other site 693216011588 G4 box; other site 693216011589 G5 box; other site 693216011590 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 693216011591 Elongation Factor G, domain II; Region: EFG_II; pfam14492 693216011592 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 693216011593 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 693216011594 30S ribosomal protein S7; Validated; Region: PRK05302 693216011595 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 693216011596 S17 interaction site [polypeptide binding]; other site 693216011597 S8 interaction site; other site 693216011598 16S rRNA interaction site [nucleotide binding]; other site 693216011599 streptomycin interaction site [chemical binding]; other site 693216011600 23S rRNA interaction site [nucleotide binding]; other site 693216011601 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 693216011602 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 693216011603 sulfur relay protein TusC; Validated; Region: PRK00211 693216011604 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 693216011605 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 693216011606 YheO-like PAS domain; Region: PAS_6; pfam08348 693216011607 HTH domain; Region: HTH_22; pfam13309 693216011608 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 693216011609 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 693216011610 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 693216011611 SlyX; Region: SlyX; pfam04102 693216011612 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737 693216011613 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 693216011614 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 693216011615 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 693216011616 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 693216011617 TrkA-N domain; Region: TrkA_N; pfam02254 693216011618 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 693216011619 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 693216011620 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693216011621 ABC transporter; Region: ABC_tran_2; pfam12848 693216011622 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693216011623 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 693216011624 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 693216011625 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 693216011626 active site 693216011627 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 693216011628 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693216011629 active site 693216011630 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 693216011631 nudix motif; other site 693216011632 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 693216011633 putative hydrolase; Provisional; Region: PRK10985 693216011634 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 693216011635 hypothetical protein; Provisional; Region: PRK04966 693216011636 phosphoribulokinase; Provisional; Region: PRK15453 693216011637 active site 693216011638 hypothetical protein; Provisional; Region: PRK10738 693216011639 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 693216011640 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 693216011641 ligand binding site [chemical binding]; other site 693216011642 flexible hinge region; other site 693216011643 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 693216011644 putative switch regulator; other site 693216011645 non-specific DNA interactions [nucleotide binding]; other site 693216011646 DNA binding site [nucleotide binding] 693216011647 sequence specific DNA binding site [nucleotide binding]; other site 693216011648 putative cAMP binding site [chemical binding]; other site 693216011649 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 693216011650 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 693216011651 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 693216011652 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 693216011653 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693216011654 inhibitor-cofactor binding pocket; inhibition site 693216011655 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216011656 catalytic residue [active] 693216011657 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 693216011658 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 693216011659 glutamine binding [chemical binding]; other site 693216011660 catalytic triad [active] 693216011661 cell filamentation protein Fic; Provisional; Region: PRK10347 693216011662 Protein of unknown function (DUF2559); Region: DUF2559; pfam10832 693216011663 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 693216011664 substrate binding site [chemical binding]; other site 693216011665 putative transporter; Provisional; Region: PRK03699 693216011666 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216011667 putative substrate translocation pore; other site 693216011668 nitrite reductase subunit NirD; Provisional; Region: PRK14989 693216011669 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 693216011670 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 693216011671 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 693216011672 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 693216011673 nitrite transporter NirC; Provisional; Region: PRK11562 693216011674 siroheme synthase; Provisional; Region: cysG; PRK10637 693216011675 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 693216011676 Sirohaem biosynthesis protein central; Region: Sirohm_synth_M; pfam14824 693216011677 Sirohaem synthase dimerization region; Region: CysG_dimeriser; pfam10414 693216011678 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 693216011679 active site 693216011680 SAM binding site [chemical binding]; other site 693216011681 homodimer interface [polypeptide binding]; other site 693216011682 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 693216011683 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 693216011684 fructoselysine-6-P-deglycase; Provisional; Region: frlB; PRK11382 693216011685 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 693216011686 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 693216011687 dimer interface [polypeptide binding]; other site 693216011688 active site 693216011689 fructoselysine 3-epimerase; Provisional; Region: PRK09856 693216011690 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 693216011691 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 693216011692 substrate binding site [chemical binding]; other site 693216011693 ATP binding site [chemical binding]; other site 693216011694 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 693216011695 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693216011696 DNA-binding site [nucleotide binding]; DNA binding site 693216011697 UTRA domain; Region: UTRA; pfam07702 693216011698 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 693216011699 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 693216011700 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 693216011701 active site 693216011702 HIGH motif; other site 693216011703 dimer interface [polypeptide binding]; other site 693216011704 KMSKS motif; other site 693216011705 phosphoglycolate phosphatase; Provisional; Region: PRK13222 693216011706 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 693216011707 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693216011708 motif II; other site 693216011709 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 693216011710 substrate binding site [chemical binding]; other site 693216011711 hexamer interface [polypeptide binding]; other site 693216011712 metal binding site [ion binding]; metal-binding site 693216011713 DNA adenine methylase; Provisional; Region: PRK10904 693216011714 cell division protein DamX; Validated; Region: PRK10905 693216011715 Sporulation related domain; Region: SPOR; pfam05036 693216011716 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 693216011717 active site 693216011718 dimer interface [polypeptide binding]; other site 693216011719 metal binding site [ion binding]; metal-binding site 693216011720 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 693216011721 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 693216011722 ADP binding site [chemical binding]; other site 693216011723 magnesium binding site [ion binding]; other site 693216011724 putative shikimate binding site; other site 693216011725 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 693216011726 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 693216011727 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 693216011728 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 693216011729 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 693216011730 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 693216011731 Transglycosylase; Region: Transgly; pfam00912 693216011732 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 693216011733 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 693216011734 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 693216011735 ADP-ribose binding site [chemical binding]; other site 693216011736 dimer interface [polypeptide binding]; other site 693216011737 active site 693216011738 nudix motif; other site 693216011739 metal binding site [ion binding]; metal-binding site 693216011740 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 693216011741 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 693216011742 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693216011743 active site 693216011744 motif I; other site 693216011745 motif II; other site 693216011746 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693216011747 RNA binding surface [nucleotide binding]; other site 693216011748 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 693216011749 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 693216011750 dimerization interface [polypeptide binding]; other site 693216011751 domain crossover interface; other site 693216011752 redox-dependent activation switch; other site 693216011753 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 693216011754 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 693216011755 active site 693216011756 substrate-binding site [chemical binding]; other site 693216011757 metal-binding site [ion binding] 693216011758 ATP binding site [chemical binding]; other site 693216011759 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 693216011760 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693216011761 dimerization interface [polypeptide binding]; other site 693216011762 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693216011763 dimer interface [polypeptide binding]; other site 693216011764 phosphorylation site [posttranslational modification] 693216011765 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693216011766 ATP binding site [chemical binding]; other site 693216011767 Mg2+ binding site [ion binding]; other site 693216011768 G-X-G motif; other site 693216011769 osmolarity response regulator; Provisional; Region: ompR; PRK09468 693216011770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693216011771 active site 693216011772 phosphorylation site [posttranslational modification] 693216011773 intermolecular recognition site; other site 693216011774 dimerization interface [polypeptide binding]; other site 693216011775 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693216011776 DNA binding site [nucleotide binding] 693216011777 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 693216011778 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 693216011779 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 693216011780 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 693216011781 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 693216011782 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 693216011783 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 693216011784 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 693216011785 RNA binding site [nucleotide binding]; other site 693216011786 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 693216011787 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 693216011788 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 693216011789 G1 box; other site 693216011790 GTP/Mg2+ binding site [chemical binding]; other site 693216011791 Switch I region; other site 693216011792 G2 box; other site 693216011793 G3 box; other site 693216011794 Switch II region; other site 693216011795 G4 box; other site 693216011796 G5 box; other site 693216011797 Nucleoside recognition; Region: Gate; pfam07670 693216011798 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 693216011799 Nucleoside recognition; Region: Gate; pfam07670 693216011800 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 693216011801 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 693216011802 carboxylesterase BioH; Provisional; Region: PRK10349 693216011803 Putative lysophospholipase; Region: Hydrolase_4; cl19140 693216011804 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 693216011805 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693216011806 active site 693216011807 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 693216011808 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 693216011809 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 693216011810 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 693216011811 DNA-binding site [nucleotide binding]; DNA binding site 693216011812 RNA-binding motif; other site 693216011813 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 693216011814 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 693216011815 maltodextrin phosphorylase; Provisional; Region: PRK14985 693216011816 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 693216011817 active site pocket [active] 693216011818 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693216011819 transcriptional regulator MalT; Provisional; Region: PRK04841 693216011820 AAA ATPase domain; Region: AAA_16; pfam13191 693216011821 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693216011822 DNA binding residues [nucleotide binding] 693216011823 dimerization interface [polypeptide binding]; other site 693216011824 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 693216011825 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 693216011826 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 693216011827 intramembrane serine protease GlpG; Provisional; Region: PRK10907 693216011828 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 693216011829 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 693216011830 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 693216011831 active site residue [active] 693216011832 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 693216011833 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 693216011834 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693216011835 metal binding site [ion binding]; metal-binding site 693216011836 active site 693216011837 I-site; other site 693216011838 glycogen phosphorylase; Provisional; Region: PRK14986 693216011839 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 693216011840 homodimer interface [polypeptide binding]; other site 693216011841 active site pocket [active] 693216011842 glycogen synthase; Provisional; Region: glgA; PRK00654 693216011843 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 693216011844 ADP-binding pocket [chemical binding]; other site 693216011845 homodimer interface [polypeptide binding]; other site 693216011846 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 693216011847 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 693216011848 ligand binding site; other site 693216011849 oligomer interface; other site 693216011850 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 693216011851 dimer interface [polypeptide binding]; other site 693216011852 N-terminal domain interface [polypeptide binding]; other site 693216011853 sulfate 1 binding site; other site 693216011854 glycogen debranching enzyme; Provisional; Region: PRK03705 693216011855 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 693216011856 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 693216011857 active site 693216011858 catalytic site [active] 693216011859 glycogen branching enzyme; Provisional; Region: PRK05402 693216011860 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 693216011861 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 693216011862 active site 693216011863 catalytic site [active] 693216011864 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 693216011865 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 693216011866 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 693216011867 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 693216011868 putative antibiotic transporter; Provisional; Region: PRK10739 693216011869 low affinity gluconate transporter; Provisional; Region: PRK10472 693216011870 GntP family permease; Region: GntP_permease; pfam02447 693216011871 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 693216011872 AAA domain; Region: AAA_33; pfam13671 693216011873 ATP-binding site [chemical binding]; other site 693216011874 Gluconate-6-phosphate binding site [chemical binding]; other site 693216011875 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 693216011876 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693216011877 DNA binding site [nucleotide binding] 693216011878 domain linker motif; other site 693216011879 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 693216011880 putative ligand binding site [chemical binding]; other site 693216011881 putative dimerization interface [polypeptide binding]; other site 693216011882 Pirin-related protein [General function prediction only]; Region: COG1741 693216011883 Pirin; Region: Pirin; pfam02678 693216011884 putative oxidoreductase; Provisional; Region: PRK10206 693216011885 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693216011886 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 693216011887 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 693216011888 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693216011889 Coenzyme A binding pocket [chemical binding]; other site 693216011890 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 693216011891 hypothetical protein; Provisional; Region: PRK10350 693216011892 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 693216011893 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 693216011894 putative active site [active] 693216011895 catalytic site [active] 693216011896 putative metal binding site [ion binding]; other site 693216011897 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 693216011898 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 693216011899 Walker A/P-loop; other site 693216011900 ATP binding site [chemical binding]; other site 693216011901 Q-loop/lid; other site 693216011902 ABC transporter signature motif; other site 693216011903 Walker B; other site 693216011904 D-loop; other site 693216011905 H-loop/switch region; other site 693216011906 TOBE domain; Region: TOBE_2; pfam08402 693216011907 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 693216011908 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216011909 dimer interface [polypeptide binding]; other site 693216011910 conserved gate region; other site 693216011911 putative PBP binding loops; other site 693216011912 ABC-ATPase subunit interface; other site 693216011913 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 693216011914 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216011915 dimer interface [polypeptide binding]; other site 693216011916 conserved gate region; other site 693216011917 putative PBP binding loops; other site 693216011918 ABC-ATPase subunit interface; other site 693216011919 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 693216011920 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 693216011921 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 693216011922 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 693216011923 Walker A/P-loop; other site 693216011924 ATP binding site [chemical binding]; other site 693216011925 Q-loop/lid; other site 693216011926 ABC transporter signature motif; other site 693216011927 Walker B; other site 693216011928 D-loop; other site 693216011929 H-loop/switch region; other site 693216011930 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 693216011931 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 693216011932 Walker A/P-loop; other site 693216011933 ATP binding site [chemical binding]; other site 693216011934 Q-loop/lid; other site 693216011935 ABC transporter signature motif; other site 693216011936 Walker B; other site 693216011937 D-loop; other site 693216011938 H-loop/switch region; other site 693216011939 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 693216011940 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 693216011941 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 693216011942 TM-ABC transporter signature motif; other site 693216011943 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693216011944 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 693216011945 TM-ABC transporter signature motif; other site 693216011946 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 693216011947 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 693216011948 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 693216011949 dimerization interface [polypeptide binding]; other site 693216011950 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 693216011951 ligand binding site [chemical binding]; other site 693216011952 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 693216011953 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 693216011954 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693216011955 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 693216011956 inhibitor-cofactor binding pocket; inhibition site 693216011957 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216011958 catalytic residue [active] 693216011959 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 693216011960 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693216011961 DNA-binding site [nucleotide binding]; DNA binding site 693216011962 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693216011963 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216011964 homodimer interface [polypeptide binding]; other site 693216011965 catalytic residue [active] 693216011966 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 693216011967 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693216011968 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693216011969 DNA binding residues [nucleotide binding] 693216011970 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 693216011971 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 693216011972 cell division protein FtsE; Provisional; Region: PRK10908 693216011973 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693216011974 Walker A/P-loop; other site 693216011975 ATP binding site [chemical binding]; other site 693216011976 Q-loop/lid; other site 693216011977 ABC transporter signature motif; other site 693216011978 Walker B; other site 693216011979 D-loop; other site 693216011980 H-loop/switch region; other site 693216011981 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 693216011982 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 693216011983 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 693216011984 P loop; other site 693216011985 GTP binding site [chemical binding]; other site 693216011986 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693216011987 S-adenosylmethionine binding site [chemical binding]; other site 693216011988 hypothetical protein; Provisional; Region: PRK10910 693216011989 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 693216011990 Predicted membrane protein [Function unknown]; Region: COG3714 693216011991 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 693216011992 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 693216011993 metal-binding site [ion binding] 693216011994 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 693216011995 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 693216011996 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 693216011997 DctM-like transporters; Region: DctM; pfam06808 693216011998 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 693216011999 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 693216012000 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 693216012001 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 693216012002 CPxP motif; other site 693216012003 hypothetical protein; Provisional; Region: PRK11212 693216012004 hypothetical protein; Provisional; Region: PRK11615 693216012005 major facilitator superfamily transporter; Provisional; Region: PRK05122 693216012006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216012007 putative substrate translocation pore; other site 693216012008 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 693216012009 Domain of unknown function DUF20; Region: UPF0118; cl00465 693216012010 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 693216012011 O-methyltransferase; Region: Methyltransf_2; pfam00891 693216012012 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 693216012013 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 693216012014 putative acyl-acceptor binding pocket; other site 693216012015 Phosphopantetheine attachment site; Region: PP-binding; cl09936 693216012016 acyl carrier protein; Provisional; Region: PRK05350 693216012017 Predicted membrane protein [Function unknown]; Region: COG4648 693216012018 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 693216012019 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 693216012020 acyl-activating enzyme (AAE) consensus motif; other site 693216012021 active site 693216012022 AMP binding site [chemical binding]; other site 693216012023 CoA binding site [chemical binding]; other site 693216012024 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 693216012025 active site 2 [active] 693216012026 active site 1 [active] 693216012027 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 693216012028 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 693216012029 Ligand binding site; other site 693216012030 Putative Catalytic site; other site 693216012031 DXD motif; other site 693216012032 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 693216012033 putative acyl-acceptor binding pocket; other site 693216012034 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 693216012035 active site 693216012036 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl19192 693216012037 Predicted exporter [General function prediction only]; Region: COG4258 693216012038 MMPL family; Region: MMPL; cl14618 693216012039 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 693216012040 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 693216012041 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 693216012042 dimer interface [polypeptide binding]; other site 693216012043 active site 693216012044 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 693216012045 active site 2 [active] 693216012046 active site 1 [active] 693216012047 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693216012048 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 693216012049 NAD(P) binding site [chemical binding]; other site 693216012050 active site 693216012051 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 693216012052 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 693216012053 dimer interface [polypeptide binding]; other site 693216012054 active site 693216012055 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 693216012056 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 693216012057 NlpC/P60 family; Region: NLPC_P60; pfam00877 693216012058 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 693216012059 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 693216012060 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 693216012061 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 693216012062 active site 693216012063 homotetramer interface [polypeptide binding]; other site 693216012064 Predicted flavoproteins [General function prediction only]; Region: COG2081 693216012065 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 693216012066 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 693216012067 universal stress protein UspB; Provisional; Region: PRK04960 693216012068 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 693216012069 Ligand Binding Site [chemical binding]; other site 693216012070 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693216012071 S-adenosylmethionine binding site [chemical binding]; other site 693216012072 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 693216012073 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 693216012074 active site 693216012075 Zn binding site [ion binding]; other site 693216012076 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 693216012077 glutathione reductase; Validated; Region: PRK06116 693216012078 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 693216012079 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693216012080 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 693216012081 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 693216012082 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 693216012083 hypothetical protein; Provisional; Region: PRK10053 693216012084 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 693216012085 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693216012086 NAD(P) binding site [chemical binding]; other site 693216012087 active site 693216012088 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693216012089 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216012090 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 693216012091 putative effector binding pocket; other site 693216012092 putative dimerization interface [polypeptide binding]; other site 693216012093 inner membrane protein YhjD; Region: TIGR00766 693216012094 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216012095 metabolite-proton symporter; Region: 2A0106; TIGR00883 693216012096 putative substrate translocation pore; other site 693216012097 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 693216012098 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 693216012099 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693216012100 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 693216012101 substrate binding site [chemical binding]; other site 693216012102 ATP binding site [chemical binding]; other site 693216012103 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 693216012104 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 693216012105 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 693216012106 putative diguanylate cyclase; Provisional; Region: PRK13561 693216012107 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693216012108 dimerization interface [polypeptide binding]; other site 693216012109 diguanylate cyclase; Region: GGDEF; smart00267 693216012110 nucleotidyl binding site; other site 693216012111 metal binding site [ion binding]; metal-binding site 693216012112 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693216012113 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 693216012114 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693216012115 TPR motif; other site 693216012116 binding surface 693216012117 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693216012118 binding surface 693216012119 TPR motif; other site 693216012120 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 693216012121 endo-1,4-D-glucanase; Provisional; Region: PRK11097 693216012122 cellulose synthase regulator protein; Provisional; Region: PRK11114 693216012123 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 693216012124 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 693216012125 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 693216012126 DXD motif; other site 693216012127 PilZ domain; Region: PilZ; pfam07238 693216012128 YhjQ protein; Region: YhjQ; pfam06564 693216012129 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 693216012130 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 693216012131 Protein of unknown function (DUF2819); Region: DUF2819; cl17862 693216012132 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 693216012133 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 693216012134 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 693216012135 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693216012136 Walker A/P-loop; other site 693216012137 ATP binding site [chemical binding]; other site 693216012138 Q-loop/lid; other site 693216012139 ABC transporter signature motif; other site 693216012140 Walker B; other site 693216012141 D-loop; other site 693216012142 H-loop/switch region; other site 693216012143 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693216012144 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 693216012145 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693216012146 Walker A/P-loop; other site 693216012147 ATP binding site [chemical binding]; other site 693216012148 Q-loop/lid; other site 693216012149 ABC transporter signature motif; other site 693216012150 Walker B; other site 693216012151 D-loop; other site 693216012152 H-loop/switch region; other site 693216012153 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693216012154 dipeptide transporter; Provisional; Region: PRK10913 693216012155 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 693216012156 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216012157 dimer interface [polypeptide binding]; other site 693216012158 conserved gate region; other site 693216012159 putative PBP binding loops; other site 693216012160 ABC-ATPase subunit interface; other site 693216012161 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 693216012162 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693216012163 dimer interface [polypeptide binding]; other site 693216012164 conserved gate region; other site 693216012165 putative PBP binding loops; other site 693216012166 ABC-ATPase subunit interface; other site 693216012167 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693216012168 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 693216012169 peptide binding site [polypeptide binding]; other site 693216012170 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 693216012171 phosphoethanolamine transferase; Provisional; Region: PRK11560 693216012172 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 693216012173 Sulfatase; Region: Sulfatase; pfam00884 693216012174 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 693216012175 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 693216012176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216012177 putative substrate translocation pore; other site 693216012178 Autotransporter beta-domain; Region: Autotransporter; cl17461 693216012179 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 693216012180 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 693216012181 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693216012182 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 693216012183 Coenzyme A binding pocket [chemical binding]; other site 693216012184 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 693216012185 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 693216012186 molybdopterin cofactor binding site [chemical binding]; other site 693216012187 substrate binding site [chemical binding]; other site 693216012188 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 693216012189 molybdopterin cofactor binding site; other site 693216012190 putative outer membrane lipoprotein; Provisional; Region: PRK10510 693216012191 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693216012192 ligand binding site [chemical binding]; other site 693216012193 zinc/cadmium-binding protein; Provisional; Region: PRK10306 693216012194 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693216012195 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693216012196 DNA binding site [nucleotide binding] 693216012197 domain linker motif; other site 693216012198 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 693216012199 putative dimerization interface [polypeptide binding]; other site 693216012200 putative ligand binding site [chemical binding]; other site 693216012201 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 693216012202 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 693216012203 substrate binding site [chemical binding]; other site 693216012204 ATP binding site [chemical binding]; other site 693216012205 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216012206 D-galactonate transporter; Region: 2A0114; TIGR00893 693216012207 putative substrate translocation pore; other site 693216012208 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 693216012209 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 693216012210 dimerization interface [polypeptide binding]; other site 693216012211 ligand binding site [chemical binding]; other site 693216012212 NADP binding site [chemical binding]; other site 693216012213 catalytic site [active] 693216012214 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 693216012215 small toxic polypeptide; Provisional; Region: PRK09738 693216012216 Predicted transcriptional regulator [Transcription]; Region: COG2944 693216012217 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693216012218 salt bridge; other site 693216012219 non-specific DNA binding site [nucleotide binding]; other site 693216012220 sequence-specific DNA binding site [nucleotide binding]; other site 693216012221 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 693216012222 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 693216012223 DALR anticodon binding domain; Region: DALR_1; pfam05746 693216012224 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 693216012225 dimer interface [polypeptide binding]; other site 693216012226 motif 1; other site 693216012227 active site 693216012228 motif 2; other site 693216012229 motif 3; other site 693216012230 YsaB-like lipoprotein; Region: YsaB; pfam13983 693216012231 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 693216012232 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 693216012233 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 693216012234 conserved cys residue [active] 693216012235 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693216012236 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 693216012237 catalytic triad [active] 693216012238 conserved cis-peptide bond; other site 693216012239 xylulokinase; Provisional; Region: PRK15027 693216012240 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 693216012241 N- and C-terminal domain interface [polypeptide binding]; other site 693216012242 active site 693216012243 MgATP binding site [chemical binding]; other site 693216012244 catalytic site [active] 693216012245 metal binding site [ion binding]; metal-binding site 693216012246 xylulose binding site [chemical binding]; other site 693216012247 homodimer interface [polypeptide binding]; other site 693216012248 xylose isomerase; Provisional; Region: PRK05474 693216012249 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 693216012250 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 693216012251 putative ligand binding site [chemical binding]; other site 693216012252 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 693216012253 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693216012254 Walker A/P-loop; other site 693216012255 ATP binding site [chemical binding]; other site 693216012256 Q-loop/lid; other site 693216012257 ABC transporter signature motif; other site 693216012258 Walker B; other site 693216012259 D-loop; other site 693216012260 H-loop/switch region; other site 693216012261 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693216012262 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693216012263 TM-ABC transporter signature motif; other site 693216012264 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 693216012265 putative dimerization interface [polypeptide binding]; other site 693216012266 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693216012267 putative ligand binding site [chemical binding]; other site 693216012268 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693216012269 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693216012270 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693216012271 hypothetical protein; Provisional; Region: PRK10356 693216012272 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 693216012273 alpha-amylase; Reviewed; Region: malS; PRK09505 693216012274 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 693216012275 active site 693216012276 catalytic site [active] 693216012277 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 693216012278 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693216012279 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216012280 homodimer interface [polypeptide binding]; other site 693216012281 catalytic residue [active] 693216012282 putative alpha-glucosidase; Provisional; Region: PRK10658 693216012283 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 693216012284 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 693216012285 active site 693216012286 homotrimer interface [polypeptide binding]; other site 693216012287 catalytic site [active] 693216012288 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 693216012289 putative transporter; Provisional; Region: PRK11462 693216012290 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 693216012291 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 693216012292 Protein of unknown function (DUF796); Region: DUF796; cl01226 693216012293 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693216012294 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693216012295 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693216012296 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693216012297 active site 693216012298 catalytic tetrad [active] 693216012299 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 693216012300 Ligand binding site; other site 693216012301 metal-binding site 693216012302 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 693216012303 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 693216012304 XdhC Rossmann domain; Region: XdhC_C; pfam13478 693216012305 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 693216012306 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 693216012307 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 693216012308 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 693216012309 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 693216012310 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 693216012311 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 693216012312 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693216012313 catalytic loop [active] 693216012314 iron binding site [ion binding]; other site 693216012315 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 693216012316 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 693216012317 putative metal binding site; other site 693216012318 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693216012319 binding surface 693216012320 TPR motif; other site 693216012321 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693216012322 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216012323 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 693216012324 putative effector binding pocket; other site 693216012325 putative dimerization interface [polypeptide binding]; other site 693216012326 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 693216012327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216012328 putative substrate translocation pore; other site 693216012329 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 693216012330 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 693216012331 putative NAD(P) binding site [chemical binding]; other site 693216012332 putative substrate binding site [chemical binding]; other site 693216012333 catalytic Zn binding site [ion binding]; other site 693216012334 structural Zn binding site [ion binding]; other site 693216012335 dimer interface [polypeptide binding]; other site 693216012336 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 693216012337 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 693216012338 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 693216012339 CAAX protease self-immunity; Region: Abi; pfam02517 693216012340 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 693216012341 HAMP domain; Region: HAMP; pfam00672 693216012342 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693216012343 dimer interface [polypeptide binding]; other site 693216012344 phosphorylation site [posttranslational modification] 693216012345 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693216012346 ATP binding site [chemical binding]; other site 693216012347 Mg2+ binding site [ion binding]; other site 693216012348 G-X-G motif; other site 693216012349 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 693216012350 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693216012351 active site 693216012352 phosphorylation site [posttranslational modification] 693216012353 intermolecular recognition site; other site 693216012354 dimerization interface [polypeptide binding]; other site 693216012355 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693216012356 DNA binding site [nucleotide binding] 693216012357 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 693216012358 active site 693216012359 homotetramer interface [polypeptide binding]; other site 693216012360 anion transporter; Region: dass; TIGR00785 693216012361 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 693216012362 transmembrane helices; other site 693216012363 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 693216012364 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693216012365 substrate binding pocket [chemical binding]; other site 693216012366 membrane-bound complex binding site; other site 693216012367 hinge residues; other site 693216012368 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 693216012369 active site 693216012370 ADP/pyrophosphate binding site [chemical binding]; other site 693216012371 dimerization interface [polypeptide binding]; other site 693216012372 allosteric effector site; other site 693216012373 fructose-1,6-bisphosphate binding site; other site 693216012374 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 693216012375 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 693216012376 dimer interface [polypeptide binding]; other site 693216012377 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 693216012378 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693216012379 active site 693216012380 intermolecular recognition site; other site 693216012381 dimerization interface [polypeptide binding]; other site 693216012382 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693216012383 DNA binding site [nucleotide binding] 693216012384 two-component sensor protein; Provisional; Region: cpxA; PRK09470 693216012385 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693216012386 dimerization interface [polypeptide binding]; other site 693216012387 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693216012388 dimer interface [polypeptide binding]; other site 693216012389 phosphorylation site [posttranslational modification] 693216012390 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693216012391 ATP binding site [chemical binding]; other site 693216012392 Mg2+ binding site [ion binding]; other site 693216012393 G-X-G motif; other site 693216012394 putative rRNA methylase; Provisional; Region: PRK10358 693216012395 serine acetyltransferase; Provisional; Region: cysE; PRK11132 693216012396 Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971 693216012397 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 693216012398 trimer interface [polypeptide binding]; other site 693216012399 active site 693216012400 substrate binding site [chemical binding]; other site 693216012401 CoA binding site [chemical binding]; other site 693216012402 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 693216012403 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 693216012404 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 693216012405 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 693216012406 SecA binding site; other site 693216012407 Preprotein binding site; other site 693216012408 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 693216012409 GSH binding site [chemical binding]; other site 693216012410 catalytic residues [active] 693216012411 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 693216012412 active site residue [active] 693216012413 phosphoglyceromutase; Provisional; Region: PRK05434 693216012414 AmiB activator; Provisional; Region: PRK11637 693216012415 HemX; Region: HemX; cl19375 693216012416 Peptidase family M23; Region: Peptidase_M23; pfam01551 693216012417 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 693216012418 NodB motif; other site 693216012419 putative active site [active] 693216012420 putative catalytic site [active] 693216012421 Zn binding site [ion binding]; other site 693216012422 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 693216012423 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; cl19952 693216012424 colanic acid biosynthesis glycosyl transferase WcaA; Region: WcaA; TIGR04017 693216012425 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 693216012426 active site 693216012427 O-Antigen ligase; Region: Wzy_C; pfam04932 693216012428 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 693216012429 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 693216012430 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 693216012431 Sulfatase; Region: Sulfatase; pfam00884 693216012432 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 693216012433 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 693216012434 NAD(P) binding site [chemical binding]; other site 693216012435 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 693216012436 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 693216012437 substrate-cofactor binding pocket; other site 693216012438 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216012439 catalytic residue [active] 693216012440 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 693216012441 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 693216012442 NADP binding site [chemical binding]; other site 693216012443 homopentamer interface [polypeptide binding]; other site 693216012444 substrate binding site [chemical binding]; other site 693216012445 active site 693216012446 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 693216012447 putative active site [active] 693216012448 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 693216012449 putative active site [active] 693216012450 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 693216012451 putative active site [active] 693216012452 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693216012453 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 693216012454 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693216012455 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 693216012456 putative ADP-binding pocket [chemical binding]; other site 693216012457 putative glycosyl transferase; Provisional; Region: PRK10073 693216012458 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 693216012459 active site 693216012460 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 693216012461 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 693216012462 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 693216012463 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 693216012464 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 693216012465 putative metal binding site; other site 693216012466 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 693216012467 active site 693216012468 (T/H)XGH motif; other site 693216012469 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 693216012470 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 693216012471 DNA binding site [nucleotide binding] 693216012472 catalytic residue [active] 693216012473 H2TH interface [polypeptide binding]; other site 693216012474 putative catalytic residues [active] 693216012475 turnover-facilitating residue; other site 693216012476 intercalation triad [nucleotide binding]; other site 693216012477 8OG recognition residue [nucleotide binding]; other site 693216012478 putative reading head residues; other site 693216012479 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 693216012480 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 693216012481 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 693216012482 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 693216012483 hypothetical protein; Reviewed; Region: PRK00024 693216012484 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 693216012485 MPN+ (JAMM) motif; other site 693216012486 Zinc-binding site [ion binding]; other site 693216012487 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 693216012488 Flavoprotein; Region: Flavoprotein; cl19190 693216012489 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 693216012490 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 693216012491 trimer interface [polypeptide binding]; other site 693216012492 active site 693216012493 division inhibitor protein; Provisional; Region: slmA; PRK09480 693216012494 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693216012495 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693216012496 active site 693216012497 ribonuclease PH; Reviewed; Region: rph; PRK00173 693216012498 Ribonuclease PH; Region: RNase_PH_bact; cd11362 693216012499 hexamer interface [polypeptide binding]; other site 693216012500 active site 693216012501 hypothetical protein; Provisional; Region: PRK11820 693216012502 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 693216012503 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 693216012504 Predicted membrane protein [Function unknown]; Region: COG2860 693216012505 UPF0126 domain; Region: UPF0126; pfam03458 693216012506 UPF0126 domain; Region: UPF0126; pfam03458 693216012507 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 693216012508 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 693216012509 nucleotide binding pocket [chemical binding]; other site 693216012510 K-X-D-G motif; other site 693216012511 catalytic site [active] 693216012512 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 693216012513 Guanylate kinase; Region: Guanylate_kin; pfam00625 693216012514 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 693216012515 catalytic site [active] 693216012516 G-X2-G-X-G-K; other site 693216012517 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 693216012518 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 693216012519 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693216012520 Zn2+ binding site [ion binding]; other site 693216012521 Mg2+ binding site [ion binding]; other site 693216012522 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 693216012523 synthetase active site [active] 693216012524 NTP binding site [chemical binding]; other site 693216012525 metal binding site [ion binding]; metal-binding site 693216012526 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 693216012527 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 693216012528 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 693216012529 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 693216012530 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 693216012531 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 693216012532 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 693216012533 generic binding surface II; other site 693216012534 ssDNA binding site; other site 693216012535 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693216012536 ATP binding site [chemical binding]; other site 693216012537 putative Mg++ binding site [ion binding]; other site 693216012538 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693216012539 nucleotide binding region [chemical binding]; other site 693216012540 ATP-binding site [chemical binding]; other site 693216012541 Fimbrial protein; Region: Fimbrial; pfam00419 693216012542 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 693216012543 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 693216012544 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 693216012545 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 693216012546 PapC N-terminal domain; Region: PapC_N; pfam13954 693216012547 Outer membrane usher protein; Region: Usher; pfam00577 693216012548 PapC C-terminal domain; Region: PapC_C; pfam13953 693216012549 Fimbrial protein; Region: Fimbrial; pfam00419 693216012550 Fimbrial protein; Region: Fimbrial; pfam00419 693216012551 Fimbrial protein; Region: Fimbrial; cl01416 693216012552 Fimbrial protein; Region: Fimbrial; pfam00419 693216012553 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 693216012554 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 693216012555 Sulfate transporter family; Region: Sulfate_transp; cl19250 693216012556 AsmA family; Region: AsmA; pfam05170 693216012557 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 693216012558 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 693216012559 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693216012560 Coenzyme A binding pocket [chemical binding]; other site 693216012561 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 693216012562 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 693216012563 putative active site [active] 693216012564 dimerization interface [polypeptide binding]; other site 693216012565 putative tRNAtyr binding site [nucleotide binding]; other site 693216012566 hypothetical protein; Reviewed; Region: PRK01637 693216012567 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 693216012568 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 693216012569 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693216012570 motif II; other site 693216012571 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 693216012572 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 693216012573 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 693216012574 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 693216012575 substrate binding site [chemical binding]; other site 693216012576 ATP binding site [chemical binding]; other site 693216012577 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 693216012578 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 693216012579 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 693216012580 Class I aldolases; Region: Aldolase_Class_I; cl17187 693216012581 catalytic residue [active] 693216012582 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 693216012583 dimerization interface [polypeptide binding]; other site 693216012584 putative active cleft [active] 693216012585 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 693216012586 active site 693216012587 catalytic residues [active] 693216012588 alpha-glucosidase; Provisional; Region: PRK10426 693216012589 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 693216012590 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 693216012591 putative active site [active] 693216012592 putative catalytic site [active] 693216012593 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 693216012594 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 693216012595 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216012596 putative substrate translocation pore; other site 693216012597 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 693216012598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216012599 putative substrate translocation pore; other site 693216012600 outer membrane porin L; Provisional; Region: ompL; PRK09980 693216012601 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 693216012602 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 693216012603 G1 box; other site 693216012604 putative GEF interaction site [polypeptide binding]; other site 693216012605 GTP/Mg2+ binding site [chemical binding]; other site 693216012606 Switch I region; other site 693216012607 G2 box; other site 693216012608 G3 box; other site 693216012609 Switch II region; other site 693216012610 G4 box; other site 693216012611 G5 box; other site 693216012612 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 693216012613 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 693216012614 glutamine synthetase; Provisional; Region: glnA; PRK09469 693216012615 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 693216012616 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 693216012617 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 693216012618 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693216012619 putative active site [active] 693216012620 heme pocket [chemical binding]; other site 693216012621 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693216012622 dimer interface [polypeptide binding]; other site 693216012623 phosphorylation site [posttranslational modification] 693216012624 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693216012625 ATP binding site [chemical binding]; other site 693216012626 Mg2+ binding site [ion binding]; other site 693216012627 G-X-G motif; other site 693216012628 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 693216012629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693216012630 active site 693216012631 phosphorylation site [posttranslational modification] 693216012632 intermolecular recognition site; other site 693216012633 dimerization interface [polypeptide binding]; other site 693216012634 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693216012635 Walker A motif; other site 693216012636 ATP binding site [chemical binding]; other site 693216012637 Walker B motif; other site 693216012638 arginine finger; other site 693216012639 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 693216012640 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 693216012641 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693216012642 FeS/SAM binding site; other site 693216012643 HemN C-terminal domain; Region: HemN_C; pfam06969 693216012644 Der GTPase activator; Provisional; Region: PRK05244 693216012645 Predicted GTPase [General function prediction only]; Region: COG0218 693216012646 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 693216012647 G1 box; other site 693216012648 GTP/Mg2+ binding site [chemical binding]; other site 693216012649 Switch I region; other site 693216012650 G2 box; other site 693216012651 G3 box; other site 693216012652 Switch II region; other site 693216012653 G4 box; other site 693216012654 G5 box; other site 693216012655 DNA polymerase I; Provisional; Region: PRK05755 693216012656 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 693216012657 active site 693216012658 metal binding site 1 [ion binding]; metal-binding site 693216012659 putative 5' ssDNA interaction site; other site 693216012660 metal binding site 3; metal-binding site 693216012661 metal binding site 2 [ion binding]; metal-binding site 693216012662 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 693216012663 putative DNA binding site [nucleotide binding]; other site 693216012664 putative metal binding site [ion binding]; other site 693216012665 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 693216012666 active site 693216012667 catalytic site [active] 693216012668 substrate binding site [chemical binding]; other site 693216012669 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 693216012670 active site 693216012671 DNA binding site [nucleotide binding] 693216012672 catalytic site [active] 693216012673 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 693216012674 putative acyl-acceptor binding pocket; other site 693216012675 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 693216012676 catalytic residues [active] 693216012677 hinge region; other site 693216012678 alpha helical domain; other site 693216012679 serine/threonine protein kinase; Provisional; Region: PRK11768 693216012680 Phosphotransferase enzyme family; Region: APH; pfam01636 693216012681 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 693216012682 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 693216012683 GTP binding site; other site 693216012684 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 693216012685 Walker A motif; other site 693216012686 Transcriptional regulators [Transcription]; Region: FadR; COG2186 693216012687 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693216012688 DNA-binding site [nucleotide binding]; DNA binding site 693216012689 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 693216012690 putative transporter; Provisional; Region: PRK10504 693216012691 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216012692 putative substrate translocation pore; other site 693216012693 transcriptional repressor RbsR; Provisional; Region: PRK10423 693216012694 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693216012695 DNA binding site [nucleotide binding] 693216012696 domain linker motif; other site 693216012697 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 693216012698 dimerization interface [polypeptide binding]; other site 693216012699 ligand binding site [chemical binding]; other site 693216012700 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 693216012701 substrate binding site [chemical binding]; other site 693216012702 dimer interface [polypeptide binding]; other site 693216012703 ATP binding site [chemical binding]; other site 693216012704 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 693216012705 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 693216012706 ligand binding site [chemical binding]; other site 693216012707 dimerization interface [polypeptide binding]; other site 693216012708 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693216012709 TM-ABC transporter signature motif; other site 693216012710 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 693216012711 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693216012712 Walker A/P-loop; other site 693216012713 ATP binding site [chemical binding]; other site 693216012714 Q-loop/lid; other site 693216012715 ABC transporter signature motif; other site 693216012716 Walker B; other site 693216012717 D-loop; other site 693216012718 H-loop/switch region; other site 693216012719 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693216012720 D-ribose pyranase; Provisional; Region: PRK11797 693216012721 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 693216012722 regulatory ATPase RavA; Provisional; Region: PRK13531 693216012723 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693216012724 Walker A motif; other site 693216012725 ATP binding site [chemical binding]; other site 693216012726 Walker B motif; other site 693216012727 arginine finger; other site 693216012728 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 693216012729 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2425 693216012730 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 693216012731 metal ion-dependent adhesion site (MIDAS); other site 693216012732 Asparagine synthetase A [Amino acid transport and metabolism]; Region: AsnA; COG2502 693216012733 motif 1; other site 693216012734 dimer interface [polypeptide binding]; other site 693216012735 active site 693216012736 motif 2; other site 693216012737 motif 3; other site 693216012738 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 693216012739 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693216012740 putative DNA binding site [nucleotide binding]; other site 693216012741 putative Zn2+ binding site [ion binding]; other site 693216012742 AsnC family; Region: AsnC_trans_reg; pfam01037 693216012743 FMN-binding protein MioC; Provisional; Region: PRK09004 693216012744 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 693216012745 catalytic core [active] 693216012746 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 693216012747 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 693216012748 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 693216012749 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 693216012750 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 693216012751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216012752 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693216012753 putative substrate translocation pore; other site 693216012754 HTH domain; Region: HTH_11; pfam08279 693216012755 Predicted transcriptional regulator [Transcription]; Region: COG2378 693216012756 WYL domain; Region: WYL; pfam13280 693216012757 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 693216012758 putative dimer interface [polypeptide binding]; other site 693216012759 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl19151 693216012760 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 693216012761 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 693216012762 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693216012763 non-specific DNA binding site [nucleotide binding]; other site 693216012764 salt bridge; other site 693216012765 sequence-specific DNA binding site [nucleotide binding]; other site 693216012766 Domain of unknown function (DUF4440); Region: DUF4440; pfam14534 693216012767 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 693216012768 nudix motif; other site 693216012769 DinB family; Region: DinB; cl17821 693216012770 ABC transporter transmembrane region; Region: ABC_membrane_3; pfam13748 693216012771 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 693216012772 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693216012773 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693216012774 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 693216012775 citrate-proton symporter; Provisional; Region: PRK15075 693216012776 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693216012777 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693216012778 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 693216012779 putative effector binding pocket; other site 693216012780 putative dimerization interface [polypeptide binding]; other site 693216012781 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693216012782 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216012783 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 693216012784 Sensors of blue-light using FAD; Region: BLUF; smart01034 693216012785 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693216012786 transcriptional regulator MirA; Provisional; Region: PRK15043 693216012787 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 693216012788 DNA binding residues [nucleotide binding] 693216012789 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 693216012790 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 693216012791 gating phenylalanine in ion channel; other site 693216012792 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693216012793 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693216012794 dimerization interface [polypeptide binding]; other site 693216012795 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693216012796 dimer interface [polypeptide binding]; other site 693216012797 putative CheW interface [polypeptide binding]; other site 693216012798 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 693216012799 active site 693216012800 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 693216012801 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 693216012802 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693216012803 active site 693216012804 Coenzyme A binding pocket [chemical binding]; other site 693216012805 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 693216012806 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 693216012807 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 693216012808 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693216012809 dimerization interface [polypeptide binding]; other site 693216012810 putative DNA binding site [nucleotide binding]; other site 693216012811 putative Zn2+ binding site [ion binding]; other site 693216012812 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 693216012813 Putative lysophospholipase; Region: Hydrolase_4; cl19140 693216012814 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 693216012815 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 693216012816 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 693216012817 active site turn [active] 693216012818 phosphorylation site [posttranslational modification] 693216012819 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 693216012820 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 693216012821 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 693216012822 metal binding site [ion binding]; metal-binding site 693216012823 substrate binding pocket [chemical binding]; other site 693216012824 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 693216012825 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693216012826 DNA-binding site [nucleotide binding]; DNA binding site 693216012827 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 693216012828 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693216012829 metal binding site [ion binding]; metal-binding site 693216012830 active site 693216012831 I-site; other site 693216012832 Protein of unknown function (DUF796); Region: DUF796; pfam05638 693216012833 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 693216012834 Cation transport protein; Region: TrkH; cl17365 693216012835 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 693216012836 catalytic residues [active] 693216012837 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 693216012838 transmembrane helices; other site 693216012839 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693216012840 putative DNA binding site [nucleotide binding]; other site 693216012841 putative Zn2+ binding site [ion binding]; other site 693216012842 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 693216012843 inhibitor site; inhibition site 693216012844 active site 693216012845 dimer interface [polypeptide binding]; other site 693216012846 catalytic residue [active] 693216012847 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 693216012848 EamA-like transporter family; Region: EamA; pfam00892 693216012849 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 693216012850 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693216012851 DNA-binding site [nucleotide binding]; DNA binding site 693216012852 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693216012853 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693216012854 homodimer interface [polypeptide binding]; other site 693216012855 catalytic residue [active] 693216012856 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 693216012857 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 693216012858 dimerization domain [polypeptide binding]; other site 693216012859 dimer interface [polypeptide binding]; other site 693216012860 catalytic residues [active] 693216012861 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 693216012862 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 693216012863 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 693216012864 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 693216012865 Walker A/P-loop; other site 693216012866 ATP binding site [chemical binding]; other site 693216012867 Q-loop/lid; other site 693216012868 ABC transporter signature motif; other site 693216012869 Walker B; other site 693216012870 D-loop; other site 693216012871 H-loop/switch region; other site 693216012872 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 693216012873 ABC-ATPase subunit interface; other site 693216012874 dimer interface [polypeptide binding]; other site 693216012875 putative PBP binding regions; other site 693216012876 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 693216012877 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 693216012878 intersubunit interface [polypeptide binding]; other site 693216012879 multidrug resistance protein MdtH; Provisional; Region: PRK11646 693216012880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216012881 putative substrate translocation pore; other site 693216012882 transcriptional antiterminator BglG; Provisional; Region: PRK09772 693216012883 CAT RNA binding domain; Region: CAT_RBD; smart01061 693216012884 PRD domain; Region: PRD; pfam00874 693216012885 PRD domain; Region: PRD; pfam00874 693216012886 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 693216012887 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 693216012888 active site turn [active] 693216012889 phosphorylation site [posttranslational modification] 693216012890 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 693216012891 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 693216012892 HPr interaction site; other site 693216012893 glycerol kinase (GK) interaction site [polypeptide binding]; other site 693216012894 active site 693216012895 phosphorylation site [posttranslational modification] 693216012896 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 693216012897 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 693216012898 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693216012899 active site 693216012900 DNA binding site [nucleotide binding] 693216012901 Int/Topo IB signature motif; other site 693216012902 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 693216012903 putative homodimer interface [polypeptide binding]; other site 693216012904 PLD-like domain; Region: PLDc_2; pfam13091 693216012905 putative active site [active] 693216012906 catalytic site [active] 693216012907 DEAD-like helicases superfamily; Region: DEXDc; smart00487 693216012908 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693216012909 putative Mg++ binding site [ion binding]; other site 693216012910 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 693216012911 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693216012912 short chain dehydrogenase; Region: adh_short; pfam00106 693216012913 NAD(P) binding site [chemical binding]; other site 693216012914 active site 693216012915 Putative lysophospholipase; Region: Hydrolase_4; cl19140 693216012916 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 693216012917 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; cl19952 693216012918 Tyrosine phosphatase family; Region: Y_phosphatase3; cl19170 693216012919 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 693216012920 Acyltransferase family; Region: Acyl_transf_3; cl19154 693216012921 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 693216012922 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 693216012923 HAMP domain; Region: HAMP; pfam00672 693216012924 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693216012925 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693216012926 dimer interface [polypeptide binding]; other site 693216012927 putative CheW interface [polypeptide binding]; other site 693216012928 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 693216012929 guanine deaminase; Provisional; Region: PRK09228 693216012930 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 693216012931 active site 693216012932 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 693216012933 Cache domain; Region: Cache_1; pfam02743 693216012934 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693216012935 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693216012936 dimer interface [polypeptide binding]; other site 693216012937 putative CheW interface [polypeptide binding]; other site 693216012938 AAA ATPase domain; Region: AAA_16; pfam13191 693216012939 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 693216012940 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 693216012941 magnesium-transporting ATPase; Provisional; Region: PRK15122 693216012942 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 693216012943 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 693216012944 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 693216012945 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 693216012946 Uncharacterized conserved protein [Function unknown]; Region: COG2850 693216012947 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 693216012948 Putative Ig domain; Region: He_PIG; pfam05345 693216012949 Autotransporter beta-domain; Region: Autotransporter; smart00869 693216012950 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 693216012951 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 693216012952 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 693216012953 active site 693216012954 catalytic site [active] 693216012955 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 693216012956 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 693216012957 active site 693216012958 catalytic site [active] 693216012959 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 693216012960 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 693216012961 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 693216012962 catalytic site [active] 693216012963 active site 693216012964 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 693216012965 HipA N-terminal domain; Region: Couple_hipA; cl11853 693216012966 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 693216012967 HipA-like N-terminal domain; Region: HipA_N; pfam07805 693216012968 HipA-like C-terminal domain; Region: HipA_C; pfam07804 693216012969 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693216012970 salt bridge; other site 693216012971 non-specific DNA binding site [nucleotide binding]; other site 693216012972 sequence-specific DNA binding site [nucleotide binding]; other site 693216012973 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 693216012974 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 693216012975 FAD binding pocket [chemical binding]; other site 693216012976 FAD binding motif [chemical binding]; other site 693216012977 phosphate binding motif [ion binding]; other site 693216012978 NAD binding pocket [chemical binding]; other site 693216012979 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693216012980 putative substrate translocation pore; other site 693216012981 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 693216012982 NifQ; Region: NifQ; pfam04891 693216012983 IucA / IucC family; Region: IucA_IucC; pfam04183 693216012984 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 693216012985 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 693216012986 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 693216012987 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 693216012988 IucA / IucC family; Region: IucA_IucC; pfam04183 693216012989 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 693216012990 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 693216012991 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 693216012992 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 693216012993 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693216012994 N-terminal plug; other site 693216012995 ligand-binding site [chemical binding]; other site 693216012996 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 693216012997 ParB-like nuclease domain; Region: ParBc; cl02129 693216012998 ParB family; Region: ParB; pfam08775 693216012999 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 693216013000 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693216013001 P-loop; other site 693216013002 Magnesium ion binding site [ion binding]; other site 693216013003 Exonuclease V - a 5' deoxyribonuclease; Region: Exo5; pfam09810 693216013004 Initiator Replication protein; Region: Rep_3; pfam01051 693216013005 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 693216013006 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 693216013007 Surface antigen; Region: Bac_surface_Ag; pfam01103 693216013008 haemagglutination activity domain; Region: Haemagg_act; pfam05860 693216013009 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 693216013010 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 693216013011 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 693216013012 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 693216013013 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 693216013014 Uncharacterized protein conserved in bacteria (DUF2247); Region: DUF2247; cl01763 693216013015 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 693216013016 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 693216013017 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 693216013018 Protein of unknown function, DUF600; Region: DUF600; cl04640 693216013019 Domain of unknown function DUF87; Region: DUF87; cl19135 693216013020 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 693216013021 Staphylococcal nuclease homologues; Region: SNc; smart00318 693216013022 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 693216013023 Catalytic site; other site 693216013024 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693216013025 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 693216013026 P-loop; other site 693216013027 Magnesium ion binding site [ion binding]; other site 693216013028 SprT-like family; Region: SprT-like; pfam10263 693216013029 IncFII RepA protein family; Region: IncFII_repA; cl11495 693216013030 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693216013031 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693216013032 non-specific DNA binding site [nucleotide binding]; other site 693216013033 salt bridge; other site 693216013034 sequence-specific DNA binding site [nucleotide binding]; other site 693216013035 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), AnFA1; Region: NGN_SP_AnfA1; cd09894 693216013036 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693216013037 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693216013038 catalytic residue [active] 693216013039 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 693216013040 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 693216013041 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 693216013042 Type IV secretion system proteins; Region: T4SS; pfam07996 693216013043 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 693216013044 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 693216013045 VirB8 protein; Region: VirB8; pfam04335 693216013046 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 693216013047 VirB7 interaction site; other site 693216013048 Septum formation initiator; Region: DivIC; cl17659 693216013049 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 693216013050 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 693216013051 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 693216013052 Walker A motif; other site 693216013053 ATP binding site [chemical binding]; other site 693216013054 Walker B motif; other site 693216013055 Cag pathogenicity island protein Cag12; Region: Cag12; pfam13117 693216013056 TrbM; Region: TrbM; pfam07424 693216013057 Phage integrase family; Region: Phage_integrase; pfam00589 693216013058 active site 693216013059 DNA binding site [nucleotide binding] 693216013060 Int/Topo IB signature motif; other site 693216013061 potential frameshift: common BLAST hit: gi|226809878|ref|YP_002791572.1| RepHIA 693216013062 ParG; Region: ParG; pfam09274 693216013063 ParA-like protein; Provisional; Region: PHA02518 693216013064 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693216013065 Magnesium ion binding site [ion binding]; other site 693216013066 modulator of post-segregation killing protein; Provisional; Region: PRK13720 693216013067 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 693216013068 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 693216013069 IncFII RepA protein family; Region: IncFII_repA; cl11495 693216013070 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 693216013071 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 693216013072 WAHD domain of WASH complex; Region: WASH_WAHD; pfam11945 693216013073 TraX protein; Region: TraX; cl05434 693216013074 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 693216013075 oligomeric interface; other site 693216013076 putative active site [active] 693216013077 homodimer interface [polypeptide binding]; other site 693216013078 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 693216013079 potential frameshift: common BLAST hit: gi|152973783|ref|YP_001338822.1| plasmid F pilA-like protein, phage inhibition 693216013080 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 693216013081 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 693216013082 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693216013083 dimerization interface [polypeptide binding]; other site 693216013084 putative DNA binding site [nucleotide binding]; other site 693216013085 putative Zn2+ binding site [ion binding]; other site 693216013086 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 693216013087 potential frameshift: common BLAST hit: gi|152973478|ref|YP_001338529.1| arsenical pump-driving ATPase (arsenite-translocating ATPase) 693216013088 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 693216013089 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 693216013090 P loop; other site 693216013091 Nucleotide binding site [chemical binding]; other site 693216013092 DTAP/Switch II; other site 693216013093 Switch I; other site 693216013094 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 693216013095 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 693216013096 P loop; other site 693216013097 Nucleotide binding site [chemical binding]; other site 693216013098 DTAP/Switch II; other site 693216013099 Switch I; other site 693216013100 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 693216013101 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 693216013102 Citrate transporter; Region: CitMHS; pfam03600 693216013103 transmembrane helices; other site 693216013104 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 693216013105 catalytic residues [active] 693216013106 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 693216013107 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693216013108 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 693216013109 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 693216013110 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693216013111 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 693216013112 Coenzyme A binding pocket [chemical binding]; other site 693216013113 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 693216013114 amphipathic channel; other site 693216013115 Asn-Pro-Ala signature motifs; other site 693216013116 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 693216013117 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 693216013118 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693216013119 dimerization interface [polypeptide binding]; other site 693216013120 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693216013121 dimer interface [polypeptide binding]; other site 693216013122 phosphorylation site [posttranslational modification] 693216013123 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693216013124 ATP binding site [chemical binding]; other site 693216013125 Mg2+ binding site [ion binding]; other site 693216013126 G-X-G motif; other site 693216013127 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 693216013128 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693216013129 active site 693216013130 phosphorylation site [posttranslational modification] 693216013131 intermolecular recognition site; other site 693216013132 dimerization interface [polypeptide binding]; other site 693216013133 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693216013134 DNA binding site [nucleotide binding] 693216013135 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 693216013136 CopC domain; Region: CopC; pfam04234 693216013137 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 693216013138 potential frameshift: common BLAST hit: gi|170021406|ref|YP_001726360.1| CopA family copper resistance protein 693216013139 The third cupredoxin domain of CopA copper resistance protein family; Region: CuRO_3_CopA; cd13896 693216013140 putative Domain 2 interface [polypeptide binding]; other site 693216013141 Type 1 (T1) Cu binding site [ion binding]; other site 693216013142 putative Domain 1 interface [polypeptide binding]; other site 693216013143 trinuclear Cu binding site [ion binding]; other site 693216013144 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 693216013145 The first cupredoxin domain of CopA copper resistance protein family; Region: CuRO_1_CopA; cd13848 693216013146 putative Domain 2 interface [polypeptide binding]; other site 693216013147 putative Domain 3 interface [polypeptide binding]; other site 693216013148 trinuclear Cu binding site [ion binding]; other site 693216013149 The second cupredoxin domain of CopA copper resistance protein family; Region: CuRO_2_CopA; cd13874 693216013150 putative Domain 1 interface [polypeptide binding]; other site 693216013151 putative Domain 3 interface [polypeptide binding]; other site 693216013152 Peptidase family M23; Region: Peptidase_M23; pfam01551 693216013153 Protein of unknown function (DUF2933); Region: DUF2933; pfam11666 693216013154 YHS domain; Region: YHS; pfam04945 693216013155 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 693216013156 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 693216013157 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693216013158 motif II; other site 693216013159 Protein of unknown function, DUF; Region: DUF411; cl01142 693216013160 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 693216013161 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693216013162 HlyD family secretion protein; Region: HlyD_3; pfam13437 693216013163 periplasmic copper-binding protein; Provisional; Region: PRK09838 693216013164 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 693216013165 Outer membrane efflux protein; Region: OEP; pfam02321 693216013166 Outer membrane efflux protein; Region: OEP; pfam02321 693216013167 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 693216013168 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693216013169 active site 693216013170 phosphorylation site [posttranslational modification] 693216013171 intermolecular recognition site; other site 693216013172 dimerization interface [polypeptide binding]; other site 693216013173 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693216013174 DNA binding site [nucleotide binding] 693216013175 potential frameshift: common BLAST hit: gi|58000300|ref|YP_190194.1| sensor kinase CusS 693216013176 sensor kinase CusS; Provisional; Region: PRK09835 693216013177 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693216013178 dimerization interface [polypeptide binding]; other site 693216013179 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693216013180 dimer interface [polypeptide binding]; other site 693216013181 phosphorylation site [posttranslational modification] 693216013182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693216013183 ATP binding site [chemical binding]; other site 693216013184 Mg2+ binding site [ion binding]; other site 693216013185 G-X-G motif; other site 693216013186 Domain of unknown function (DUF305); Region: DUF305; cl17794 693216013187 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 693216013188 active site