-- dump date 20140619_054000 -- class Genbank::misc_feature -- table misc_feature_note -- id note 469378000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 469378000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 469378000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 469378000004 Walker A motif; other site 469378000005 ATP binding site [chemical binding]; other site 469378000006 Walker B motif; other site 469378000007 arginine finger; other site 469378000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 469378000009 DnaA box-binding interface [nucleotide binding]; other site 469378000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 469378000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 469378000012 putative DNA binding surface [nucleotide binding]; other site 469378000013 dimer interface [polypeptide binding]; other site 469378000014 beta-clamp/clamp loader binding surface; other site 469378000015 beta-clamp/translesion DNA polymerase binding surface; other site 469378000016 recombination protein F; Reviewed; Region: recF; PRK00064 469378000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469378000018 Walker A/P-loop; other site 469378000019 ATP binding site [chemical binding]; other site 469378000020 Q-loop/lid; other site 469378000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469378000022 ABC transporter signature motif; other site 469378000023 Walker B; other site 469378000024 D-loop; other site 469378000025 H-loop/switch region; other site 469378000026 Protein of unknown function (DUF721); Region: DUF721; pfam05258 469378000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 469378000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469378000029 Mg2+ binding site [ion binding]; other site 469378000030 G-X-G motif; other site 469378000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 469378000032 anchoring element; other site 469378000033 dimer interface [polypeptide binding]; other site 469378000034 ATP binding site [chemical binding]; other site 469378000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 469378000036 active site 469378000037 putative metal-binding site [ion binding]; other site 469378000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 469378000039 DNA gyrase subunit A; Validated; Region: PRK05560 469378000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 469378000041 CAP-like domain; other site 469378000042 active site 469378000043 primary dimer interface [polypeptide binding]; other site 469378000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 469378000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 469378000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 469378000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 469378000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 469378000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 469378000050 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 469378000051 HSP70 interaction site [polypeptide binding]; other site 469378000052 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 469378000053 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 469378000054 G1 box; other site 469378000055 putative GEF interaction site [polypeptide binding]; other site 469378000056 GTP/Mg2+ binding site [chemical binding]; other site 469378000057 Switch I region; other site 469378000058 G2 box; other site 469378000059 G3 box; other site 469378000060 Switch II region; other site 469378000061 G4 box; other site 469378000062 G5 box; other site 469378000063 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 469378000064 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 469378000065 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 469378000066 ApbE family; Region: ApbE; pfam02424 469378000067 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 469378000068 active site 469378000069 homotetramer interface [polypeptide binding]; other site 469378000070 homodimer interface [polypeptide binding]; other site 469378000071 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 469378000072 Part of AAA domain; Region: AAA_19; pfam13245 469378000073 Family description; Region: UvrD_C_2; pfam13538 469378000074 methionine aminopeptidase; Provisional; Region: PRK12318 469378000075 SEC-C motif; Region: SEC-C; pfam02810 469378000076 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 469378000077 active site 469378000078 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 469378000079 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 469378000080 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 469378000081 homodimer interface [polypeptide binding]; other site 469378000082 NADP binding site [chemical binding]; other site 469378000083 substrate binding site [chemical binding]; other site 469378000084 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 469378000085 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 469378000086 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 469378000087 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 469378000088 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 469378000089 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 469378000090 catalytic loop [active] 469378000091 iron binding site [ion binding]; other site 469378000092 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 469378000093 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 469378000094 [4Fe-4S] binding site [ion binding]; other site 469378000095 molybdopterin cofactor binding site; other site 469378000096 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 469378000097 molybdopterin cofactor binding site; other site 469378000098 Peptidase family C69; Region: Peptidase_C69; cl17793 469378000099 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 469378000100 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 469378000101 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 469378000102 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 469378000103 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 469378000104 LytTr DNA-binding domain; Region: LytTR; smart00850 469378000105 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 469378000106 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 469378000107 dimer interface [polypeptide binding]; other site 469378000108 phosphorylation site [posttranslational modification] 469378000109 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469378000110 ATP binding site [chemical binding]; other site 469378000111 Mg2+ binding site [ion binding]; other site 469378000112 G-X-G motif; other site 469378000113 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 469378000114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469378000115 active site 469378000116 phosphorylation site [posttranslational modification] 469378000117 intermolecular recognition site; other site 469378000118 dimerization interface [polypeptide binding]; other site 469378000119 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 469378000120 DNA binding site [nucleotide binding] 469378000121 nascent polypeptide-associated complex protein; Reviewed; Region: nac; PRK06369 469378000122 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 469378000123 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 469378000124 KH domain; Region: KH_4; pfam13083 469378000125 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 469378000126 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 469378000127 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 469378000128 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 469378000129 Catalytic site [active] 469378000130 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 469378000131 dimer interface [polypeptide binding]; other site 469378000132 motif 1; other site 469378000133 active site 469378000134 motif 2; other site 469378000135 motif 3; other site 469378000136 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 469378000137 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 469378000138 pyruvate phosphate dikinase; Provisional; Region: PRK09279 469378000139 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 469378000140 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 469378000141 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 469378000142 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 469378000143 amino acid carrier protein; Region: agcS; TIGR00835 469378000144 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 469378000145 putative uracil binding site [chemical binding]; other site 469378000146 putative active site [active] 469378000147 Cupin domain; Region: Cupin_2; cl17218 469378000148 coproporphyrinogen III oxidase; Provisional; Region: PRK08629 469378000149 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 469378000150 FeS/SAM binding site; other site 469378000151 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 469378000152 Uncharacterized conserved protein [Function unknown]; Region: COG2461 469378000153 Family of unknown function (DUF438); Region: DUF438; pfam04282 469378000154 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 469378000155 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469378000156 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469378000157 DNA binding residues [nucleotide binding] 469378000158 dimerization interface [polypeptide binding]; other site 469378000159 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 469378000160 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 469378000161 molybdopterin cofactor binding site; other site 469378000162 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 469378000163 molybdopterin cofactor binding site; other site 469378000164 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 469378000165 4Fe-4S binding domain; Region: Fer4; pfam00037 469378000166 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 469378000167 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 469378000168 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 469378000169 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 469378000170 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 469378000171 CPxP motif; other site 469378000172 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 469378000173 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 469378000174 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 469378000175 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 469378000176 FeS/SAM binding site; other site 469378000177 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 469378000178 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 469378000179 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 469378000180 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 469378000181 active site 469378000182 metal binding site [ion binding]; metal-binding site 469378000183 nickel responsive regulator; Provisional; Region: PRK04460 469378000184 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 469378000185 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 469378000186 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 469378000187 dimerization interface [polypeptide binding]; other site 469378000188 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 469378000189 ATP binding site [chemical binding]; other site 469378000190 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 469378000191 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 469378000192 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 469378000193 nucleotide binding site [chemical binding]; other site 469378000194 NEF interaction site [polypeptide binding]; other site 469378000195 SBD interface [polypeptide binding]; other site 469378000196 GrpE; Region: GrpE; pfam01025 469378000197 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 469378000198 dimer interface [polypeptide binding]; other site 469378000199 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 469378000200 chaperone protein DnaJ; Provisional; Region: PRK14299 469378000201 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 469378000202 HSP70 interaction site [polypeptide binding]; other site 469378000203 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 469378000204 substrate binding site [polypeptide binding]; other site 469378000205 dimer interface [polypeptide binding]; other site 469378000206 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 469378000207 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 469378000208 DNA binding residues [nucleotide binding] 469378000209 putative dimer interface [polypeptide binding]; other site 469378000210 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 469378000211 Clp amino terminal domain; Region: Clp_N; pfam02861 469378000212 Clp amino terminal domain; Region: Clp_N; pfam02861 469378000213 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 469378000214 Walker A motif; other site 469378000215 ATP binding site [chemical binding]; other site 469378000216 Walker B motif; other site 469378000217 arginine finger; other site 469378000218 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 469378000219 Walker A motif; other site 469378000220 ATP binding site [chemical binding]; other site 469378000221 Walker B motif; other site 469378000222 arginine finger; other site 469378000223 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 469378000224 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 469378000225 catalytic motif [active] 469378000226 Zn binding site [ion binding]; other site 469378000227 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 469378000228 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 469378000229 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 469378000230 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 469378000231 Predicted GTPases [General function prediction only]; Region: COG1162 469378000232 RNA binding site [nucleotide binding]; other site 469378000233 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 469378000234 GTPase/Zn-binding domain interface [polypeptide binding]; other site 469378000235 GTP/Mg2+ binding site [chemical binding]; other site 469378000236 G4 box; other site 469378000237 G5 box; other site 469378000238 G1 box; other site 469378000239 Switch I region; other site 469378000240 G2 box; other site 469378000241 G3 box; other site 469378000242 Switch II region; other site 469378000243 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 469378000244 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 469378000245 active site 469378000246 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 469378000247 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 469378000248 Part of AAA domain; Region: AAA_19; pfam13245 469378000249 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 469378000250 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 469378000251 Uncharacterized conserved protein [Function unknown]; Region: COG1739 469378000252 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 469378000253 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 469378000254 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 469378000255 Cna protein B-type domain; Region: Cna_B; pfam05738 469378000256 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 469378000257 T surface-antigen of pili; Region: FctA; pfam12892 469378000258 Cna protein B-type domain; Region: Cna_B; pfam05738 469378000259 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 469378000260 Cna protein B-type domain; Region: Cna_B; pfam05738 469378000261 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 469378000262 active site 469378000263 catalytic site [active] 469378000264 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 469378000265 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 469378000266 dimer interface [polypeptide binding]; other site 469378000267 active site 469378000268 metal binding site [ion binding]; metal-binding site 469378000269 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 469378000270 LrgA family; Region: LrgA; pfam03788 469378000271 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 469378000272 MarR family; Region: MarR; pfam01047 469378000273 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 469378000274 putative active site [active] 469378000275 RelB antitoxin; Region: RelB; cl01171 469378000276 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 469378000277 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 469378000278 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 469378000279 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 469378000280 [4Fe-4S] binding site [ion binding]; other site 469378000281 molybdopterin cofactor binding site; other site 469378000282 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 469378000283 molybdopterin cofactor binding site; other site 469378000284 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 469378000285 hydrogenase 4 subunit B; Validated; Region: PRK06521 469378000286 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 469378000287 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 469378000288 NADH dehydrogenase; Region: NADHdh; cl00469 469378000289 hydrogenase 4 subunit D; Validated; Region: PRK06525 469378000290 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 469378000291 hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492 469378000292 hydrogenase 4 subunit F; Validated; Region: PRK06458 469378000293 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 469378000294 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 469378000295 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 469378000296 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 469378000297 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143 469378000298 4Fe-4S binding domain; Region: Fer4; pfam00037 469378000299 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 469378000300 Formate hydrogenlyase maturation protein HycH; Region: HycH; pfam07450 469378000301 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 469378000302 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 469378000303 nickel binding site [ion binding]; other site 469378000304 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 469378000305 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 469378000306 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469378000307 Walker A/P-loop; other site 469378000308 ATP binding site [chemical binding]; other site 469378000309 Q-loop/lid; other site 469378000310 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469378000311 ABC transporter signature motif; other site 469378000312 Walker B; other site 469378000313 D-loop; other site 469378000314 H-loop/switch region; other site 469378000315 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 469378000316 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 469378000317 active site 469378000318 metal binding site [ion binding]; metal-binding site 469378000319 DNA binding site [nucleotide binding] 469378000320 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 469378000321 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 469378000322 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 469378000323 Walker A/P-loop; other site 469378000324 ATP binding site [chemical binding]; other site 469378000325 Q-loop/lid; other site 469378000326 ABC transporter signature motif; other site 469378000327 Walker B; other site 469378000328 D-loop; other site 469378000329 H-loop/switch region; other site 469378000330 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 469378000331 FtsX-like permease family; Region: FtsX; pfam02687 469378000332 hybrid cluster protein; Provisional; Region: PRK05290 469378000333 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 469378000334 ACS interaction site; other site 469378000335 CODH interaction site; other site 469378000336 metal cluster binding site [ion binding]; other site 469378000337 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 469378000338 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 469378000339 ligand binding site [chemical binding]; other site 469378000340 flexible hinge region; other site 469378000341 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 469378000342 non-specific DNA interactions [nucleotide binding]; other site 469378000343 DNA binding site [nucleotide binding] 469378000344 sequence specific DNA binding site [nucleotide binding]; other site 469378000345 putative cAMP binding site [chemical binding]; other site 469378000346 endonuclease IV; Provisional; Region: PRK01060 469378000347 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 469378000348 AP (apurinic/apyrimidinic) site pocket; other site 469378000349 DNA interaction; other site 469378000350 Metal-binding active site; metal-binding site 469378000351 peroxiredoxin; Region: AhpC; TIGR03137 469378000352 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 469378000353 dimer interface [polypeptide binding]; other site 469378000354 decamer (pentamer of dimers) interface [polypeptide binding]; other site 469378000355 catalytic triad [active] 469378000356 peroxidatic and resolving cysteines [active] 469378000357 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 469378000358 metal binding site 2 [ion binding]; metal-binding site 469378000359 putative DNA binding helix; other site 469378000360 metal binding site 1 [ion binding]; metal-binding site 469378000361 dimer interface [polypeptide binding]; other site 469378000362 structural Zn2+ binding site [ion binding]; other site 469378000363 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 469378000364 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 469378000365 Histidine kinase; Region: His_kinase; pfam06580 469378000366 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469378000367 ATP binding site [chemical binding]; other site 469378000368 Mg2+ binding site [ion binding]; other site 469378000369 G-X-G motif; other site 469378000370 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 469378000371 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469378000372 active site 469378000373 phosphorylation site [posttranslational modification] 469378000374 intermolecular recognition site; other site 469378000375 dimerization interface [polypeptide binding]; other site 469378000376 LytTr DNA-binding domain; Region: LytTR; pfam04397 469378000377 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 469378000378 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 469378000379 Acylphosphatase; Region: Acylphosphatase; pfam00708 469378000380 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 469378000381 HypF finger; Region: zf-HYPF; pfam07503 469378000382 HypF finger; Region: zf-HYPF; pfam07503 469378000383 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 469378000384 HupF/HypC family; Region: HupF_HypC; pfam01455 469378000385 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 469378000386 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 469378000387 Uncharacterized conserved protein [Function unknown]; Region: COG3402 469378000388 Bacterial PH domain; Region: DUF304; pfam03703 469378000389 Bacterial PH domain; Region: DUF304; pfam03703 469378000390 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 469378000391 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 469378000392 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 469378000393 Domain of unknown function DUF21; Region: DUF21; pfam01595 469378000394 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 469378000395 Transporter associated domain; Region: CorC_HlyC; smart01091 469378000396 PspC domain; Region: PspC; pfam04024 469378000397 PspC domain; Region: PspC; pfam04024 469378000398 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 469378000399 TrkA-N domain; Region: TrkA_N; pfam02254 469378000400 TrkA-C domain; Region: TrkA_C; pfam02080 469378000401 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 469378000402 TrkA-N domain; Region: TrkA_N; pfam02254 469378000403 TrkA-C domain; Region: TrkA_C; pfam02080 469378000404 adenylosuccinate lyase; Provisional; Region: PRK07492 469378000405 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 469378000406 tetramer interface [polypeptide binding]; other site 469378000407 active site 469378000408 Adenylosuccinate lyase C-terminus; Region: ADSL_C; pfam10397 469378000409 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 469378000410 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 469378000411 Histidine kinase; Region: HisKA_3; pfam07730 469378000412 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469378000413 ATP binding site [chemical binding]; other site 469378000414 Mg2+ binding site [ion binding]; other site 469378000415 G-X-G motif; other site 469378000416 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469378000417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469378000418 active site 469378000419 phosphorylation site [posttranslational modification] 469378000420 intermolecular recognition site; other site 469378000421 dimerization interface [polypeptide binding]; other site 469378000422 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469378000423 DNA binding residues [nucleotide binding] 469378000424 dimerization interface [polypeptide binding]; other site 469378000425 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 469378000426 oligomerisation interface [polypeptide binding]; other site 469378000427 mobile loop; other site 469378000428 roof hairpin; other site 469378000429 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 469378000430 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 469378000431 ring oligomerisation interface [polypeptide binding]; other site 469378000432 ATP/Mg binding site [chemical binding]; other site 469378000433 stacking interactions; other site 469378000434 hinge regions; other site 469378000435 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 469378000436 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 469378000437 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 469378000438 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 469378000439 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 469378000440 Cna protein B-type domain; Region: Cna_B; pfam05738 469378000441 Cna protein B-type domain; Region: Cna_B; pfam05738 469378000442 Cna protein B-type domain; Region: Cna_B; pfam05738 469378000443 Cna protein B-type domain; Region: Cna_B; pfam05738 469378000444 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 469378000445 shikimate kinase; Reviewed; Region: aroK; PRK00131 469378000446 ADP binding site [chemical binding]; other site 469378000447 magnesium binding site [ion binding]; other site 469378000448 putative shikimate binding site; other site 469378000449 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 469378000450 rRNA binding site [nucleotide binding]; other site 469378000451 predicted 30S ribosome binding site; other site 469378000452 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 469378000453 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 469378000454 30S ribosomal protein S13; Region: bact_S13; TIGR03631 469378000455 30S ribosomal protein S11; Validated; Region: PRK05309 469378000456 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 469378000457 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 469378000458 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 469378000459 RNA binding surface [nucleotide binding]; other site 469378000460 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 469378000461 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 469378000462 alphaNTD - beta interaction site [polypeptide binding]; other site 469378000463 alphaNTD homodimer interface [polypeptide binding]; other site 469378000464 alphaNTD - beta' interaction site [polypeptide binding]; other site 469378000465 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 469378000466 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 469378000467 Cobalt transport protein; Region: CbiQ; cl00463 469378000468 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 469378000469 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 469378000470 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 469378000471 dimer interface [polypeptide binding]; other site 469378000472 putative functional site; other site 469378000473 putative MPT binding site; other site 469378000474 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 469378000475 MPT binding site; other site 469378000476 trimer interface [polypeptide binding]; other site 469378000477 alanine racemase; Reviewed; Region: alr; PRK00053 469378000478 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 469378000479 active site 469378000480 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 469378000481 dimer interface [polypeptide binding]; other site 469378000482 substrate binding site [chemical binding]; other site 469378000483 catalytic residues [active] 469378000484 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 469378000485 Fe-S cluster binding site [ion binding]; other site 469378000486 active site 469378000487 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 469378000488 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 469378000489 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 469378000490 FAD binding domain; Region: FAD_binding_2; pfam00890 469378000491 Predicted oxidoreductase [General function prediction only]; Region: COG3573 469378000492 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 469378000493 active site 469378000494 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 469378000495 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 469378000496 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 469378000497 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 469378000498 Walker A motif; other site 469378000499 ATP binding site [chemical binding]; other site 469378000500 Walker B motif; other site 469378000501 arginine finger; other site 469378000502 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 469378000503 hypothetical protein; Validated; Region: PRK00153 469378000504 recombination protein RecR; Reviewed; Region: recR; PRK00076 469378000505 RecR protein; Region: RecR; pfam02132 469378000506 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 469378000507 putative active site [active] 469378000508 putative metal-binding site [ion binding]; other site 469378000509 tetramer interface [polypeptide binding]; other site 469378000510 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 469378000511 HD domain; Region: HD; pfam01966 469378000512 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 469378000513 Amidinotransferase; Region: Amidinotransf; cl12043 469378000514 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 469378000515 transaminase; Validated; Region: PRK07324 469378000516 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 469378000517 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469378000518 homodimer interface [polypeptide binding]; other site 469378000519 catalytic residue [active] 469378000520 Transcriptional regulator [Transcription]; Region: LytR; COG1316 469378000521 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 469378000522 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 469378000523 diaminopimelate decarboxylase; Region: lysA; TIGR01048 469378000524 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 469378000525 active site 469378000526 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 469378000527 substrate binding site [chemical binding]; other site 469378000528 catalytic residues [active] 469378000529 dimer interface [polypeptide binding]; other site 469378000530 homoserine dehydrogenase; Provisional; Region: PRK06349 469378000531 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 469378000532 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 469378000533 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 469378000534 Glucan-binding protein C; Region: GbpC; pfam08363 469378000535 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 469378000536 23S rRNA interface [nucleotide binding]; other site 469378000537 L3 interface [polypeptide binding]; other site 469378000538 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 469378000539 B3/4 domain; Region: B3_4; pfam03483 469378000540 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 469378000541 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 469378000542 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 469378000543 hypothetical protein; Validated; Region: PRK07121 469378000544 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469378000545 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469378000546 DNA binding residues [nucleotide binding] 469378000547 dimerization interface [polypeptide binding]; other site 469378000548 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 469378000549 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 469378000550 substrate-cofactor binding pocket; other site 469378000551 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469378000552 homodimer interface [polypeptide binding]; other site 469378000553 Trp repressor protein; Region: Trp_repressor; cl17266 469378000554 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 469378000555 active site 469378000556 catalytic site [active] 469378000557 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 469378000558 dimer interface [polypeptide binding]; other site 469378000559 ADP-ribose binding site [chemical binding]; other site 469378000560 active site 469378000561 nudix motif; other site 469378000562 metal binding site [ion binding]; metal-binding site 469378000563 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 469378000564 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 469378000565 oligomer interface [polypeptide binding]; other site 469378000566 putative active site [active] 469378000567 metal binding site [ion binding]; metal-binding site 469378000568 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 469378000569 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 469378000570 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 469378000571 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 469378000572 active site 469378000573 Transcriptional regulator; Region: Rrf2; cl17282 469378000574 Rrf2 family protein; Region: rrf2_super; TIGR00738 469378000575 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 469378000576 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 469378000577 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 469378000578 catalytic residue [active] 469378000579 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 469378000580 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 469378000581 Ligand Binding Site [chemical binding]; other site 469378000582 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 469378000583 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 469378000584 HIGH motif; other site 469378000585 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 469378000586 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 469378000587 active site 469378000588 KMSKS motif; other site 469378000589 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 469378000590 tRNA binding surface [nucleotide binding]; other site 469378000591 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 469378000592 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 469378000593 ABC-ATPase subunit interface; other site 469378000594 dimer interface [polypeptide binding]; other site 469378000595 putative PBP binding regions; other site 469378000596 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 469378000597 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 469378000598 Walker A/P-loop; other site 469378000599 ATP binding site [chemical binding]; other site 469378000600 Q-loop/lid; other site 469378000601 ABC transporter signature motif; other site 469378000602 Walker B; other site 469378000603 D-loop; other site 469378000604 H-loop/switch region; other site 469378000605 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 469378000606 putative ligand binding residues [chemical binding]; other site 469378000607 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 469378000608 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 469378000609 dimerization interface [polypeptide binding]; other site 469378000610 putative Zn2+ binding site [ion binding]; other site 469378000611 putative DNA binding site [nucleotide binding]; other site 469378000612 PBP superfamily domain; Region: PBP_like; pfam12727 469378000613 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 469378000614 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 469378000615 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 469378000616 putative active site [active] 469378000617 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469378000618 metabolite-proton symporter; Region: 2A0106; TIGR00883 469378000619 putative substrate translocation pore; other site 469378000620 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 469378000621 Amidinotransferase; Region: Amidinotransf; cl12043 469378000622 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 469378000623 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 469378000624 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 469378000625 putative active site [active] 469378000626 hypothetical protein; Provisional; Region: PRK05463 469378000627 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 469378000628 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 469378000629 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 469378000630 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 469378000631 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 469378000632 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 469378000633 carboxyltransferase (CT) interaction site; other site 469378000634 biotinylation site [posttranslational modification]; other site 469378000635 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 469378000636 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 469378000637 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 469378000638 aspartate aminotransferase; Provisional; Region: PRK06836 469378000639 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 469378000640 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469378000641 homodimer interface [polypeptide binding]; other site 469378000642 catalytic residue [active] 469378000643 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 469378000644 Double zinc ribbon; Region: DZR; pfam12773 469378000645 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 469378000646 trimerization site [polypeptide binding]; other site 469378000647 active site 469378000648 hypothetical protein; Provisional; Region: PRK09947 469378000649 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469378000650 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469378000651 DNA binding residues [nucleotide binding] 469378000652 dimerization interface [polypeptide binding]; other site 469378000653 putative oxidoreductase; Provisional; Region: PRK09849 469378000654 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 469378000655 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 469378000656 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 469378000657 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 469378000658 thiosulfate reductase PhsA; Provisional; Region: PRK15488 469378000659 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 469378000660 molybdopterin cofactor binding site; other site 469378000661 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 469378000662 molybdopterin cofactor binding site; other site 469378000663 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 469378000664 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 469378000665 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 469378000666 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469378000667 S-adenosylmethionine binding site [chemical binding]; other site 469378000668 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 469378000669 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 469378000670 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 469378000671 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 469378000672 dimer interface [polypeptide binding]; other site 469378000673 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469378000674 catalytic residue [active] 469378000675 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 469378000676 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 469378000677 Ligand Binding Site [chemical binding]; other site 469378000678 Maf-like protein; Region: Maf; pfam02545 469378000679 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 469378000680 active site 469378000681 dimer interface [polypeptide binding]; other site 469378000682 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 469378000683 active site 469378000684 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 469378000685 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 469378000686 Walker A motif; other site 469378000687 ATP binding site [chemical binding]; other site 469378000688 Walker B motif; other site 469378000689 arginine finger; other site 469378000690 Peptidase family M41; Region: Peptidase_M41; pfam01434 469378000691 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 469378000692 dihydropteroate synthase; Region: DHPS; TIGR01496 469378000693 substrate binding pocket [chemical binding]; other site 469378000694 dimer interface [polypeptide binding]; other site 469378000695 inhibitor binding site; inhibition site 469378000696 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 469378000697 catalytic center binding site [active] 469378000698 ATP binding site [chemical binding]; other site 469378000699 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 469378000700 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 469378000701 BioY family; Region: BioY; pfam02632 469378000702 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 469378000703 dimer interface [polypeptide binding]; other site 469378000704 phosphorylation site [posttranslational modification] 469378000705 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469378000706 ATP binding site [chemical binding]; other site 469378000707 Mg2+ binding site [ion binding]; other site 469378000708 G-X-G motif; other site 469378000709 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 469378000710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469378000711 active site 469378000712 phosphorylation site [posttranslational modification] 469378000713 intermolecular recognition site; other site 469378000714 dimerization interface [polypeptide binding]; other site 469378000715 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 469378000716 DNA binding site [nucleotide binding] 469378000717 Type III pantothenate kinase; Region: Pan_kinase; cl17198 469378000718 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 469378000719 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 469378000720 Potassium binding sites [ion binding]; other site 469378000721 Cesium cation binding sites [ion binding]; other site 469378000722 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 469378000723 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 469378000724 hypothetical protein; Provisional; Region: PRK10410 469378000725 Arginine repressor [Transcription]; Region: ArgR; COG1438 469378000726 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 469378000727 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 469378000728 Transglycosylase; Region: Transgly; pfam00912 469378000729 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 469378000730 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 469378000731 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 469378000732 Peptidase family U32; Region: Peptidase_U32; pfam01136 469378000733 Collagenase; Region: DUF3656; pfam12392 469378000734 Peptidase family U32; Region: Peptidase_U32; cl03113 469378000735 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 469378000736 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 469378000737 active site 469378000738 HIGH motif; other site 469378000739 dimer interface [polypeptide binding]; other site 469378000740 KMSKS motif; other site 469378000741 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 469378000742 RNA binding surface [nucleotide binding]; other site 469378000743 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 469378000744 isocitrate dehydrogenase; Validated; Region: PRK06451 469378000745 aconitate hydratase; Validated; Region: PRK09277 469378000746 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 469378000747 substrate binding site [chemical binding]; other site 469378000748 ligand binding site [chemical binding]; other site 469378000749 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 469378000750 substrate binding site [chemical binding]; other site 469378000751 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 469378000752 23S rRNA interface [nucleotide binding]; other site 469378000753 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 469378000754 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 469378000755 peripheral dimer interface [polypeptide binding]; other site 469378000756 core dimer interface [polypeptide binding]; other site 469378000757 L10 interface [polypeptide binding]; other site 469378000758 L11 interface [polypeptide binding]; other site 469378000759 putative EF-Tu interaction site [polypeptide binding]; other site 469378000760 putative EF-G interaction site [polypeptide binding]; other site 469378000761 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 469378000762 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 469378000763 FeS/SAM binding site; other site 469378000764 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 469378000765 ATP cone domain; Region: ATP-cone; pfam03477 469378000766 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 469378000767 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 469378000768 active site 469378000769 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 469378000770 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 469378000771 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 469378000772 active site 469378000773 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 469378000774 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 469378000775 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 469378000776 motif II; other site 469378000777 Protein of unknown function (DUF4013); Region: DUF4013; pfam13197 469378000778 AIR carboxylase; Region: AIRC; pfam00731 469378000779 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 469378000780 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 469378000781 dimer interface [polypeptide binding]; other site 469378000782 PYR/PP interface [polypeptide binding]; other site 469378000783 TPP binding site [chemical binding]; other site 469378000784 substrate binding site [chemical binding]; other site 469378000785 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 469378000786 TPP-binding site; other site 469378000787 4Fe-4S binding domain; Region: Fer4; pfam00037 469378000788 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 469378000789 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 469378000790 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 469378000791 acyl-activating enzyme (AAE) consensus motif; other site 469378000792 AMP binding site [chemical binding]; other site 469378000793 active site 469378000794 CoA binding site [chemical binding]; other site 469378000795 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 469378000796 amidase catalytic site [active] 469378000797 Zn binding residues [ion binding]; other site 469378000798 substrate binding site [chemical binding]; other site 469378000799 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 469378000800 Bacteriophage holin; Region: Phage_holin_1; pfam04531 469378000801 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 469378000802 Bacteriophage Gp15 protein; Region: Phage_Gp15; pfam06854 469378000803 Minor capsid protein from bacteriophage; Region: Minor_capsid_3; pfam12691 469378000804 Minor capsid protein; Region: Minor_capsid_2; pfam11114 469378000805 Minor capsid protein; Region: Minor_capsid_1; pfam10665 469378000806 VRR-NUC domain; Region: VRR_NUC; pfam08774 469378000807 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 469378000808 phage portal protein, putative, A118 family; Region: A118_put_portal; TIGR01542 469378000809 Phage terminase large subunit; Region: Terminase_3; cl12054 469378000810 Terminase-like family; Region: Terminase_6; pfam03237 469378000811 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 469378000812 ParB-like nuclease domain; Region: ParBc; pfam02195 469378000813 Phi-29 DNA terminal protein GP3; Region: Phi-29_GP3; cl17520 469378000814 hypothetical protein; Validated; Region: PRK08116 469378000815 Helix-turn-helix domain; Region: HTH_39; pfam14090 469378000816 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 469378000817 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 469378000818 dimer interface [polypeptide binding]; other site 469378000819 ssDNA binding site [nucleotide binding]; other site 469378000820 tetramer (dimer of dimers) interface [polypeptide binding]; other site 469378000821 RecT family; Region: RecT; cl04285 469378000822 Protein of unknown function (DUF1351); Region: DUF1351; pfam07083 469378000823 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 469378000824 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 469378000825 non-specific DNA binding site [nucleotide binding]; other site 469378000826 salt bridge; other site 469378000827 sequence-specific DNA binding site [nucleotide binding]; other site 469378000828 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 469378000829 Catalytic site [active] 469378000830 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 469378000831 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 469378000832 ATP binding site [chemical binding]; other site 469378000833 Mg2+ binding site [ion binding]; other site 469378000834 G-X-G motif; other site 469378000835 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 469378000836 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 469378000837 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 469378000838 active site 469378000839 catalytic residues [active] 469378000840 DNA binding site [nucleotide binding] 469378000841 Int/Topo IB signature motif; other site 469378000842 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 469378000843 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 469378000844 ligand binding site [chemical binding]; other site 469378000845 flexible hinge region; other site 469378000846 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447 469378000847 GIY-YIG motif/motif A; other site 469378000848 putative active site [active] 469378000849 putative metal binding site [ion binding]; other site 469378000850 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 469378000851 HsdM N-terminal domain; Region: HsdM_N; pfam12161 469378000852 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 469378000853 Methyltransferase domain; Region: Methyltransf_26; pfam13659 469378000854 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 469378000855 Fic family protein [Function unknown]; Region: COG3177 469378000856 Fic/DOC family; Region: Fic; pfam02661 469378000857 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 469378000858 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 469378000859 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 469378000860 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 469378000861 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 469378000862 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 469378000863 ATP binding site [chemical binding]; other site 469378000864 putative Mg++ binding site [ion binding]; other site 469378000865 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 469378000866 Int/Topo IB signature motif; other site 469378000867 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 469378000868 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 469378000869 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469378000870 dimer interface [polypeptide binding]; other site 469378000871 conserved gate region; other site 469378000872 putative PBP binding loops; other site 469378000873 ABC-ATPase subunit interface; other site 469378000874 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 469378000875 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 469378000876 Walker A/P-loop; other site 469378000877 ATP binding site [chemical binding]; other site 469378000878 Q-loop/lid; other site 469378000879 ABC transporter signature motif; other site 469378000880 Walker B; other site 469378000881 D-loop; other site 469378000882 H-loop/switch region; other site 469378000883 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 469378000884 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 469378000885 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 469378000886 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 469378000887 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 469378000888 Walker A/P-loop; other site 469378000889 ATP binding site [chemical binding]; other site 469378000890 Q-loop/lid; other site 469378000891 ABC transporter signature motif; other site 469378000892 Walker B; other site 469378000893 D-loop; other site 469378000894 H-loop/switch region; other site 469378000895 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 469378000896 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 469378000897 FtsX-like permease family; Region: FtsX; pfam02687 469378000898 FtsX-like permease family; Region: FtsX; pfam02687 469378000899 Transcriptional regulator [Transcription]; Region: LysR; COG0583 469378000900 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 469378000901 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 469378000902 dimerization interface [polypeptide binding]; other site 469378000903 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 469378000904 EamA-like transporter family; Region: EamA; pfam00892 469378000905 EamA-like transporter family; Region: EamA; pfam00892 469378000906 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 469378000907 Catalytic domain of Protein Kinases; Region: PKc; cd00180 469378000908 active site 469378000909 ATP binding site [chemical binding]; other site 469378000910 substrate binding site [chemical binding]; other site 469378000911 activation loop (A-loop); other site 469378000912 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 469378000913 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 469378000914 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 469378000915 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 469378000916 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 469378000917 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 469378000918 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 469378000919 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 469378000920 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 469378000921 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 469378000922 Protein phosphatase 2C; Region: PP2C; pfam00481 469378000923 active site 469378000924 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 469378000925 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 469378000926 phosphopeptide binding site; other site 469378000927 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 469378000928 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 469378000929 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 469378000930 phosphopeptide binding site; other site 469378000931 FtsX-like permease family; Region: FtsX; pfam02687 469378000932 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 469378000933 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 469378000934 Walker A/P-loop; other site 469378000935 ATP binding site [chemical binding]; other site 469378000936 Q-loop/lid; other site 469378000937 ABC transporter signature motif; other site 469378000938 Walker B; other site 469378000939 D-loop; other site 469378000940 H-loop/switch region; other site 469378000941 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 469378000942 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469378000943 ATP binding site [chemical binding]; other site 469378000944 Mg2+ binding site [ion binding]; other site 469378000945 G-X-G motif; other site 469378000946 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 469378000947 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469378000948 active site 469378000949 phosphorylation site [posttranslational modification] 469378000950 intermolecular recognition site; other site 469378000951 dimerization interface [polypeptide binding]; other site 469378000952 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 469378000953 DNA binding site [nucleotide binding] 469378000954 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 469378000955 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 469378000956 putative ligand binding site [chemical binding]; other site 469378000957 putative NAD binding site [chemical binding]; other site 469378000958 putative catalytic site [active] 469378000959 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 469378000960 L-serine binding site [chemical binding]; other site 469378000961 ACT domain interface; other site 469378000962 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 469378000963 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 469378000964 Catalytic domain of Protein Kinases; Region: PKc; cd00180 469378000965 active site 469378000966 ATP binding site [chemical binding]; other site 469378000967 substrate binding site [chemical binding]; other site 469378000968 activation loop (A-loop); other site 469378000969 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 469378000970 dimer interface [polypeptide binding]; other site 469378000971 pyridoxal binding site [chemical binding]; other site 469378000972 ATP binding site [chemical binding]; other site 469378000973 seryl-tRNA synthetase; Provisional; Region: PRK05431 469378000974 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 469378000975 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 469378000976 dimer interface [polypeptide binding]; other site 469378000977 active site 469378000978 motif 1; other site 469378000979 motif 2; other site 469378000980 motif 3; other site 469378000981 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 469378000982 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 469378000983 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469378000984 homodimer interface [polypeptide binding]; other site 469378000985 catalytic residue [active] 469378000986 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 469378000987 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 469378000988 ATP-grasp domain; Region: ATP-grasp_4; cl17255 469378000989 Uncharacterized conserved protein [Function unknown]; Region: COG0398 469378000990 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 469378000991 TM2 domain; Region: TM2; pfam05154 469378000992 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 469378000993 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 469378000994 putative active site; other site 469378000995 catalytic residue [active] 469378000996 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 469378000997 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 469378000998 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 469378000999 putative metal binding residues [ion binding]; other site 469378001000 signature motif; other site 469378001001 dimer interface [polypeptide binding]; other site 469378001002 active site 469378001003 polyP binding site; other site 469378001004 substrate binding site [chemical binding]; other site 469378001005 acceptor-phosphate pocket; other site 469378001006 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 469378001007 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469378001008 active site 469378001009 phosphorylation site [posttranslational modification] 469378001010 intermolecular recognition site; other site 469378001011 dimerization interface [polypeptide binding]; other site 469378001012 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 469378001013 DNA binding site [nucleotide binding] 469378001014 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 469378001015 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 469378001016 dimer interface [polypeptide binding]; other site 469378001017 phosphorylation site [posttranslational modification] 469378001018 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469378001019 ATP binding site [chemical binding]; other site 469378001020 Mg2+ binding site [ion binding]; other site 469378001021 G-X-G motif; other site 469378001022 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469378001023 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469378001024 DNA binding residues [nucleotide binding] 469378001025 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 469378001026 dipeptidase, putative; Region: dipeptidaselike; TIGR01887 469378001027 active site 469378001028 metal binding site [ion binding]; metal-binding site 469378001029 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 469378001030 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 469378001031 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 469378001032 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 469378001033 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 469378001034 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469378001035 Walker A/P-loop; other site 469378001036 ATP binding site [chemical binding]; other site 469378001037 Q-loop/lid; other site 469378001038 ABC transporter signature motif; other site 469378001039 Walker B; other site 469378001040 D-loop; other site 469378001041 H-loop/switch region; other site 469378001042 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 469378001043 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 469378001044 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469378001045 Walker A/P-loop; other site 469378001046 ATP binding site [chemical binding]; other site 469378001047 Q-loop/lid; other site 469378001048 ABC transporter signature motif; other site 469378001049 Walker B; other site 469378001050 D-loop; other site 469378001051 H-loop/switch region; other site 469378001052 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469378001053 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469378001054 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 469378001055 Domain of unknown function DUF11; Region: DUF11; cl17728 469378001056 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 469378001057 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 469378001058 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 469378001059 Predicted membrane protein [Function unknown]; Region: COG1971 469378001060 Domain of unknown function DUF; Region: DUF204; pfam02659 469378001061 Domain of unknown function DUF; Region: DUF204; pfam02659 469378001062 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 469378001063 putative efflux protein, MATE family; Region: matE; TIGR00797 469378001064 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 469378001065 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 469378001066 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 469378001067 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 469378001068 catalytic residues [active] 469378001069 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 469378001070 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 469378001071 Ligand Binding Site [chemical binding]; other site 469378001072 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 469378001073 active site 469378001074 metal binding site [ion binding]; metal-binding site 469378001075 homotetramer interface [polypeptide binding]; other site 469378001076 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 469378001077 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 469378001078 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 469378001079 YacP-like NYN domain; Region: NYN_YacP; pfam05991 469378001080 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 469378001081 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 469378001082 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 469378001083 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 469378001084 RPB1 interaction site [polypeptide binding]; other site 469378001085 RPB10 interaction site [polypeptide binding]; other site 469378001086 RPB11 interaction site [polypeptide binding]; other site 469378001087 RPB3 interaction site [polypeptide binding]; other site 469378001088 RPB12 interaction site [polypeptide binding]; other site 469378001089 DNA-directed RNA polymerase subunit beta'/alpha domain fusion protein; Provisional; Region: PRK14906 469378001090 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 469378001091 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 469378001092 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 469378001093 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 469378001094 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 469378001095 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 469378001096 G-loop; other site 469378001097 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 469378001098 DNA binding site [nucleotide binding] 469378001099 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 469378001100 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 469378001101 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 469378001102 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 469378001103 active site 469378001104 substrate binding site [chemical binding]; other site 469378001105 metal binding site [ion binding]; metal-binding site 469378001106 Collagen binding domain; Region: Collagen_bind; pfam05737 469378001107 Cna protein B-type domain; Region: Cna_B; pfam05738 469378001108 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 469378001109 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 469378001110 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 469378001111 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469378001112 dimer interface [polypeptide binding]; other site 469378001113 conserved gate region; other site 469378001114 putative PBP binding loops; other site 469378001115 ABC-ATPase subunit interface; other site 469378001116 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 469378001117 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469378001118 Walker A/P-loop; other site 469378001119 ATP binding site [chemical binding]; other site 469378001120 Q-loop/lid; other site 469378001121 ABC transporter signature motif; other site 469378001122 Walker B; other site 469378001123 D-loop; other site 469378001124 H-loop/switch region; other site 469378001125 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 469378001126 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 469378001127 FeS/SAM binding site; other site 469378001128 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 469378001129 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 469378001130 trimer interface [polypeptide binding]; other site 469378001131 dimer interface [polypeptide binding]; other site 469378001132 putative active site [active] 469378001133 hypothetical protein; Validated; Region: PRK00110 469378001134 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 469378001135 Septum formation initiator; Region: DivIC; pfam04977 469378001136 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 469378001137 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 469378001138 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 469378001139 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 469378001140 substrate binding pocket [chemical binding]; other site 469378001141 chain length determination region; other site 469378001142 substrate-Mg2+ binding site; other site 469378001143 catalytic residues [active] 469378001144 aspartate-rich region 1; other site 469378001145 active site lid residues [active] 469378001146 aspartate-rich region 2; other site 469378001147 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 469378001148 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 469378001149 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 469378001150 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 469378001151 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 469378001152 Substrate binding site; other site 469378001153 Mg++ binding site; other site 469378001154 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 469378001155 active site 469378001156 substrate binding site [chemical binding]; other site 469378001157 CoA binding site [chemical binding]; other site 469378001158 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 469378001159 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 469378001160 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 469378001161 active site 469378001162 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 469378001163 putative active site [active] 469378001164 catalytic residue [active] 469378001165 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 469378001166 DHH family; Region: DHH; pfam01368 469378001167 DHHA1 domain; Region: DHHA1; pfam02272 469378001168 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 469378001169 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 469378001170 ATP binding site [chemical binding]; other site 469378001171 putative Mg++ binding site [ion binding]; other site 469378001172 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 469378001173 nucleotide binding region [chemical binding]; other site 469378001174 ATP-binding site [chemical binding]; other site 469378001175 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 469378001176 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 469378001177 Zn2+ binding site [ion binding]; other site 469378001178 Mg2+ binding site [ion binding]; other site 469378001179 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 469378001180 synthetase active site [active] 469378001181 NTP binding site [chemical binding]; other site 469378001182 metal binding site [ion binding]; metal-binding site 469378001183 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 469378001184 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 469378001185 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 469378001186 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 469378001187 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 469378001188 Predicted membrane protein [Function unknown]; Region: COG2860 469378001189 UPF0126 domain; Region: UPF0126; pfam03458 469378001190 UPF0126 domain; Region: UPF0126; pfam03458 469378001191 aspartate kinase; Reviewed; Region: PRK06635 469378001192 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 469378001193 putative nucleotide binding site [chemical binding]; other site 469378001194 putative catalytic residues [active] 469378001195 putative Mg ion binding site [ion binding]; other site 469378001196 putative aspartate binding site [chemical binding]; other site 469378001197 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 469378001198 putative allosteric regulatory site; other site 469378001199 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 469378001200 putative allosteric regulatory residue; other site 469378001201 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 469378001202 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469378001203 dimer interface [polypeptide binding]; other site 469378001204 conserved gate region; other site 469378001205 putative PBP binding loops; other site 469378001206 ABC-ATPase subunit interface; other site 469378001207 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469378001208 dimer interface [polypeptide binding]; other site 469378001209 conserved gate region; other site 469378001210 putative PBP binding loops; other site 469378001211 ABC-ATPase subunit interface; other site 469378001212 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 469378001213 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 469378001214 Walker A/P-loop; other site 469378001215 ATP binding site [chemical binding]; other site 469378001216 Q-loop/lid; other site 469378001217 ABC transporter signature motif; other site 469378001218 Walker B; other site 469378001219 D-loop; other site 469378001220 H-loop/switch region; other site 469378001221 TOBE domain; Region: TOBE_2; pfam08402 469378001222 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 469378001223 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 469378001224 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 469378001225 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 469378001226 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 469378001227 HAMP domain; Region: HAMP; pfam00672 469378001228 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 469378001229 dimer interface [polypeptide binding]; other site 469378001230 phosphorylation site [posttranslational modification] 469378001231 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469378001232 ATP binding site [chemical binding]; other site 469378001233 Mg2+ binding site [ion binding]; other site 469378001234 G-X-G motif; other site 469378001235 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 469378001236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469378001237 active site 469378001238 phosphorylation site [posttranslational modification] 469378001239 intermolecular recognition site; other site 469378001240 dimerization interface [polypeptide binding]; other site 469378001241 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 469378001242 DNA binding site [nucleotide binding] 469378001243 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 469378001244 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 469378001245 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 469378001246 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 469378001247 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469378001248 Walker A/P-loop; other site 469378001249 ATP binding site [chemical binding]; other site 469378001250 Q-loop/lid; other site 469378001251 ABC transporter signature motif; other site 469378001252 Walker B; other site 469378001253 D-loop; other site 469378001254 H-loop/switch region; other site 469378001255 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 469378001256 polyphosphate kinase; Provisional; Region: PRK05443 469378001257 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 469378001258 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 469378001259 Catalytic C-terminal domain, first repeat, of uncharacterized prokaryotic polyphosphate kinases; Region: PLDc_PPK1_C1_unchar; cd09166 469378001260 putative domain interface [polypeptide binding]; other site 469378001261 putative active site [active] 469378001262 catalytic site [active] 469378001263 Catalytic C-terminal domain, second repeat, of uncharacterized prokaryotic polyphosphate kinases; Region: PLDc_PPK1_C2_unchar; cd09169 469378001264 putative domain interface [polypeptide binding]; other site 469378001265 putative active site [active] 469378001266 catalytic site [active] 469378001267 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 469378001268 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 469378001269 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 469378001270 active site 469378001271 catalytic site [active] 469378001272 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 469378001273 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 469378001274 active site 469378001275 tetramer interface [polypeptide binding]; other site 469378001276 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 469378001277 active site 469378001278 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 469378001279 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 469378001280 dimerization interface [polypeptide binding]; other site 469378001281 putative ATP binding site [chemical binding]; other site 469378001282 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 469378001283 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 469378001284 active site 469378001285 substrate binding site [chemical binding]; other site 469378001286 cosubstrate binding site; other site 469378001287 catalytic site [active] 469378001288 XdhC Rossmann domain; Region: XdhC_C; pfam13478 469378001289 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 469378001290 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 469378001291 purine monophosphate binding site [chemical binding]; other site 469378001292 dimer interface [polypeptide binding]; other site 469378001293 putative catalytic residues [active] 469378001294 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 469378001295 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 469378001296 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 469378001297 HSP70 interaction site [polypeptide binding]; other site 469378001298 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 469378001299 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 469378001300 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 469378001301 putative PBP binding regions; other site 469378001302 ABC-ATPase subunit interface; other site 469378001303 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 469378001304 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469378001305 Walker A/P-loop; other site 469378001306 ATP binding site [chemical binding]; other site 469378001307 Q-loop/lid; other site 469378001308 ABC transporter signature motif; other site 469378001309 Walker B; other site 469378001310 D-loop; other site 469378001311 H-loop/switch region; other site 469378001312 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 469378001313 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 469378001314 metal binding site [ion binding]; metal-binding site 469378001315 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 469378001316 metal binding site 2 [ion binding]; metal-binding site 469378001317 putative DNA binding helix; other site 469378001318 metal binding site 1 [ion binding]; metal-binding site 469378001319 dimer interface [polypeptide binding]; other site 469378001320 structural Zn2+ binding site [ion binding]; other site 469378001321 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 469378001322 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 469378001323 DNA binding residues [nucleotide binding] 469378001324 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 469378001325 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 469378001326 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469378001327 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469378001328 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 469378001329 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 469378001330 substrate binding site [chemical binding]; other site 469378001331 ligand binding site [chemical binding]; other site 469378001332 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 469378001333 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 469378001334 substrate binding site [chemical binding]; other site 469378001335 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 469378001336 tartrate dehydrogenase; Region: TTC; TIGR02089 469378001337 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 469378001338 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 469378001339 substrate binding site [chemical binding]; other site 469378001340 dimer interface [polypeptide binding]; other site 469378001341 ATP binding site [chemical binding]; other site 469378001342 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 469378001343 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469378001344 putative substrate translocation pore; other site 469378001345 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 469378001346 active site 469378001347 tetramer interface [polypeptide binding]; other site 469378001348 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 469378001349 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 469378001350 dimer interface [polypeptide binding]; other site 469378001351 motif 1; other site 469378001352 active site 469378001353 motif 2; other site 469378001354 motif 3; other site 469378001355 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 469378001356 anticodon binding site; other site 469378001357 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 469378001358 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 469378001359 dimer interface [polypeptide binding]; other site 469378001360 anticodon binding site; other site 469378001361 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 469378001362 homodimer interface [polypeptide binding]; other site 469378001363 motif 1; other site 469378001364 active site 469378001365 motif 2; other site 469378001366 GAD domain; Region: GAD; pfam02938 469378001367 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 469378001368 active site 469378001369 motif 3; other site 469378001370 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 469378001371 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 469378001372 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 469378001373 active site 469378001374 dimer interface [polypeptide binding]; other site 469378001375 motif 1; other site 469378001376 motif 2; other site 469378001377 motif 3; other site 469378001378 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 469378001379 anticodon binding site; other site 469378001380 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 469378001381 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 469378001382 trifunctional thioredoxin/methionine sulfoxide reductase A/B protein; Provisional; Region: PRK14018 469378001383 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 469378001384 catalytic residues [active] 469378001385 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 469378001386 methionine sulfoxide reductase B; Provisional; Region: PRK00222 469378001387 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 469378001388 Coenzyme A binding pocket [chemical binding]; other site 469378001389 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 469378001390 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469378001391 S-adenosylmethionine binding site [chemical binding]; other site 469378001392 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 469378001393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469378001394 dimer interface [polypeptide binding]; other site 469378001395 conserved gate region; other site 469378001396 putative PBP binding loops; other site 469378001397 ABC-ATPase subunit interface; other site 469378001398 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 469378001399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469378001400 dimer interface [polypeptide binding]; other site 469378001401 conserved gate region; other site 469378001402 putative PBP binding loops; other site 469378001403 ABC-ATPase subunit interface; other site 469378001404 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 469378001405 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 469378001406 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 469378001407 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469378001408 Walker A/P-loop; other site 469378001409 ATP binding site [chemical binding]; other site 469378001410 Q-loop/lid; other site 469378001411 ABC transporter signature motif; other site 469378001412 Walker B; other site 469378001413 D-loop; other site 469378001414 H-loop/switch region; other site 469378001415 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469378001416 Walker A/P-loop; other site 469378001417 ATP binding site [chemical binding]; other site 469378001418 Q-loop/lid; other site 469378001419 ABC transporter signature motif; other site 469378001420 Walker B; other site 469378001421 D-loop; other site 469378001422 H-loop/switch region; other site 469378001423 acyl carrier protein; Provisional; Region: acpP; PRK00982 469378001424 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469378001425 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469378001426 DNA binding residues [nucleotide binding] 469378001427 dimerization interface [polypeptide binding]; other site 469378001428 Predicted membrane protein [Function unknown]; Region: COG1288 469378001429 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 469378001430 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 469378001431 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 469378001432 Peptidase M16C associated; Region: M16C_assoc; pfam08367 469378001433 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 469378001434 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 469378001435 homodimer interface [polypeptide binding]; other site 469378001436 metal binding site [ion binding]; metal-binding site 469378001437 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 469378001438 homodimer interface [polypeptide binding]; other site 469378001439 active site 469378001440 putative chemical substrate binding site [chemical binding]; other site 469378001441 Methyltransferase domain; Region: Methyltransf_31; pfam13847 469378001442 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469378001443 S-adenosylmethionine binding site [chemical binding]; other site 469378001444 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 469378001445 Trp docking motif [polypeptide binding]; other site 469378001446 FOG: WD40-like repeat [Function unknown]; Region: COG1520 469378001447 active site 469378001448 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 469378001449 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 469378001450 Walker A/P-loop; other site 469378001451 ATP binding site [chemical binding]; other site 469378001452 Q-loop/lid; other site 469378001453 ABC transporter signature motif; other site 469378001454 Walker B; other site 469378001455 D-loop; other site 469378001456 H-loop/switch region; other site 469378001457 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 469378001458 Walker A/P-loop; other site 469378001459 ATP binding site [chemical binding]; other site 469378001460 Q-loop/lid; other site 469378001461 ABC transporter signature motif; other site 469378001462 Walker B; other site 469378001463 D-loop; other site 469378001464 H-loop/switch region; other site 469378001465 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 469378001466 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 469378001467 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 469378001468 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 469378001469 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 469378001470 elongation factor G; Reviewed; Region: PRK12740 469378001471 G1 box; other site 469378001472 putative GEF interaction site [polypeptide binding]; other site 469378001473 GTP/Mg2+ binding site [chemical binding]; other site 469378001474 Switch I region; other site 469378001475 G2 box; other site 469378001476 G3 box; other site 469378001477 Switch II region; other site 469378001478 G4 box; other site 469378001479 G5 box; other site 469378001480 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 469378001481 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 469378001482 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 469378001483 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 469378001484 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 469378001485 glutaminase active site [active] 469378001486 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 469378001487 dimer interface [polypeptide binding]; other site 469378001488 active site 469378001489 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 469378001490 dimer interface [polypeptide binding]; other site 469378001491 active site 469378001492 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 469378001493 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 469378001494 putative substrate binding site [chemical binding]; other site 469378001495 putative ATP binding site [chemical binding]; other site 469378001496 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 469378001497 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 469378001498 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 469378001499 nucleotide binding pocket [chemical binding]; other site 469378001500 K-X-D-G motif; other site 469378001501 catalytic site [active] 469378001502 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 469378001503 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 469378001504 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 469378001505 Dimer interface [polypeptide binding]; other site 469378001506 BRCT sequence motif; other site 469378001507 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 469378001508 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 469378001509 RNA binding surface [nucleotide binding]; other site 469378001510 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469378001511 S-adenosylmethionine binding site [chemical binding]; other site 469378001512 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 469378001513 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 469378001514 NodB motif; other site 469378001515 active site 469378001516 catalytic site [active] 469378001517 metal binding site [ion binding]; metal-binding site 469378001518 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 469378001519 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 469378001520 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 469378001521 hypothetical protein; Provisional; Region: PRK10621 469378001522 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 469378001523 Predicted transcriptional regulators [Transcription]; Region: COG1695 469378001524 Transcriptional regulator PadR-like family; Region: PadR; cl17335 469378001525 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 469378001526 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 469378001527 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 469378001528 Domain of unknown function (DUF364); Region: DUF364; pfam04016 469378001529 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469378001530 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469378001531 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 469378001532 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 469378001533 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 469378001534 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 469378001535 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 469378001536 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 469378001537 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 469378001538 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 469378001539 Predicted methyltransferases [General function prediction only]; Region: COG0313 469378001540 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 469378001541 putative SAM binding site [chemical binding]; other site 469378001542 putative homodimer interface [polypeptide binding]; other site 469378001543 Protein of unknown function DUF45; Region: DUF45; pfam01863 469378001544 Cation efflux family; Region: Cation_efflux; cl00316 469378001545 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 469378001546 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 469378001547 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 469378001548 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 469378001549 active site 469378001550 HIGH motif; other site 469378001551 KMSKS motif; other site 469378001552 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 469378001553 tRNA binding surface [nucleotide binding]; other site 469378001554 anticodon binding site; other site 469378001555 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 469378001556 active site 469378001557 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 469378001558 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 469378001559 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 469378001560 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 469378001561 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 469378001562 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 469378001563 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 469378001564 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 469378001565 CcmE; Region: CcmE; cl00994 469378001566 CcmE; Region: CcmE; cl00994 469378001567 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 469378001568 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 469378001569 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 469378001570 Walker A/P-loop; other site 469378001571 ATP binding site [chemical binding]; other site 469378001572 Q-loop/lid; other site 469378001573 ABC transporter signature motif; other site 469378001574 Walker B; other site 469378001575 D-loop; other site 469378001576 H-loop/switch region; other site 469378001577 CcmB protein; Region: CcmB; cl17444 469378001578 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 469378001579 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 469378001580 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 469378001581 active site 469378001582 tetramer interface; other site 469378001583 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 469378001584 recombination factor protein RarA; Reviewed; Region: PRK13342 469378001585 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 469378001586 Walker A motif; other site 469378001587 ATP binding site [chemical binding]; other site 469378001588 Walker B motif; other site 469378001589 arginine finger; other site 469378001590 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 469378001591 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 469378001592 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 469378001593 Domain of unknown function DUF20; Region: UPF0118; pfam01594 469378001594 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 469378001595 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 469378001596 motif 1; other site 469378001597 active site 469378001598 motif 2; other site 469378001599 motif 3; other site 469378001600 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 469378001601 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 469378001602 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 469378001603 YceG-like family; Region: YceG; pfam02618 469378001604 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 469378001605 dimerization interface [polypeptide binding]; other site 469378001606 HAD superfamily (subfamily IIIA) phosphatase, TIGR01668; Region: YqeG_hyp_ppase 469378001607 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 469378001608 active site 469378001609 motif I; other site 469378001610 motif II; other site 469378001611 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 469378001612 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 469378001613 Tetramer interface [polypeptide binding]; other site 469378001614 active site 469378001615 FMN-binding site [chemical binding]; other site 469378001616 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 469378001617 active site 469378001618 dimer interface [polypeptide binding]; other site 469378001619 metal binding site [ion binding]; metal-binding site 469378001620 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 469378001621 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 469378001622 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 469378001623 active site 469378001624 elongation factor P; Validated; Region: PRK00529 469378001625 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 469378001626 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 469378001627 RNA binding site [nucleotide binding]; other site 469378001628 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 469378001629 RNA binding site [nucleotide binding]; other site 469378001630 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 469378001631 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 469378001632 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 469378001633 ApbE family; Region: ApbE; pfam02424 469378001634 serine/threonine transporter SstT; Provisional; Region: PRK13628 469378001635 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 469378001636 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 469378001637 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 469378001638 active site 469378001639 catalytic residues [active] 469378001640 metal binding site [ion binding]; metal-binding site 469378001641 homodimer binding site [polypeptide binding]; other site 469378001642 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 469378001643 carboxyltransferase (CT) interaction site; other site 469378001644 biotinylation site [posttranslational modification]; other site 469378001645 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 469378001646 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 469378001647 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 469378001648 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 469378001649 Asp23 family; Region: Asp23; cl00574 469378001650 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 469378001651 putative RNA binding site [nucleotide binding]; other site 469378001652 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 469378001653 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 469378001654 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 469378001655 TPP-binding site; other site 469378001656 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 469378001657 PYR/PP interface [polypeptide binding]; other site 469378001658 dimer interface [polypeptide binding]; other site 469378001659 TPP binding site [chemical binding]; other site 469378001660 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 469378001661 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 469378001662 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 469378001663 transmembrane helices; other site 469378001664 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 469378001665 RNA binding site [nucleotide binding]; other site 469378001666 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 469378001667 RNA binding site [nucleotide binding]; other site 469378001668 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 469378001669 RNA binding site [nucleotide binding]; other site 469378001670 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 469378001671 RNA binding site [nucleotide binding]; other site 469378001672 domain interface; other site 469378001673 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 469378001674 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 469378001675 CoA-binding site [chemical binding]; other site 469378001676 ATP-binding [chemical binding]; other site 469378001677 excinuclease ABC subunit B; Provisional; Region: PRK05298 469378001678 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 469378001679 ATP binding site [chemical binding]; other site 469378001680 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 469378001681 nucleotide binding region [chemical binding]; other site 469378001682 ATP-binding site [chemical binding]; other site 469378001683 Ultra-violet resistance protein B; Region: UvrB; pfam12344 469378001684 UvrB/uvrC motif; Region: UVR; pfam02151 469378001685 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 469378001686 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 469378001687 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 469378001688 FeS/SAM binding site; other site 469378001689 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 469378001690 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 469378001691 dimer interface [polypeptide binding]; other site 469378001692 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469378001693 catalytic residue [active] 469378001694 Protein of unknown function (DUF454); Region: DUF454; cl01063 469378001695 Transcriptional regulator; Region: Rrf2; cl17282 469378001696 Rrf2 family protein; Region: rrf2_super; TIGR00738 469378001697 4Fe-4S binding domain; Region: Fer4; pfam00037 469378001698 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 469378001699 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 469378001700 putative active site [active] 469378001701 dimerization interface [polypeptide binding]; other site 469378001702 putative tRNAtyr binding site [nucleotide binding]; other site 469378001703 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 469378001704 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469378001705 Walker A/P-loop; other site 469378001706 ATP binding site [chemical binding]; other site 469378001707 Q-loop/lid; other site 469378001708 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 469378001709 ABC transporter signature motif; other site 469378001710 Walker B; other site 469378001711 D-loop; other site 469378001712 H-loop/switch region; other site 469378001713 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 469378001714 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 469378001715 active site 469378001716 NTP binding site [chemical binding]; other site 469378001717 metal binding triad [ion binding]; metal-binding site 469378001718 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 469378001719 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 469378001720 Zn2+ binding site [ion binding]; other site 469378001721 Mg2+ binding site [ion binding]; other site 469378001722 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 469378001723 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 469378001724 putative metal binding site [ion binding]; other site 469378001725 Uncharacterized conserved protein [Function unknown]; Region: COG1432 469378001726 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 469378001727 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 469378001728 Bacterial transcriptional activator domain; Region: BTAD; smart01043 469378001729 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 469378001730 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 469378001731 SEC-C motif; Region: SEC-C; pfam02810 469378001732 peptide chain release factor 2; Validated; Region: prfB; PRK00578 469378001733 PCRF domain; Region: PCRF; pfam03462 469378001734 RF-1 domain; Region: RF-1; pfam00472 469378001735 transketolase; Reviewed; Region: PRK05899 469378001736 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 469378001737 TPP-binding site [chemical binding]; other site 469378001738 dimer interface [polypeptide binding]; other site 469378001739 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 469378001740 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 469378001741 PYR/PP interface [polypeptide binding]; other site 469378001742 dimer interface [polypeptide binding]; other site 469378001743 TPP binding site [chemical binding]; other site 469378001744 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 469378001745 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 469378001746 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469378001747 Walker A/P-loop; other site 469378001748 ATP binding site [chemical binding]; other site 469378001749 Q-loop/lid; other site 469378001750 ABC transporter signature motif; other site 469378001751 Walker B; other site 469378001752 D-loop; other site 469378001753 H-loop/switch region; other site 469378001754 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 469378001755 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 469378001756 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 469378001757 protein binding site [polypeptide binding]; other site 469378001758 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 469378001759 Catalytic dyad [active] 469378001760 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 469378001761 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 469378001762 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 469378001763 active site 469378001764 metal binding site [ion binding]; metal-binding site 469378001765 oligomer interface [polypeptide binding]; other site 469378001766 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 469378001767 SmpB-tmRNA interface; other site 469378001768 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 469378001769 Asp23 family; Region: Asp23; pfam03780 469378001770 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 469378001771 DAK2 domain; Region: Dak2; pfam02734 469378001772 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 469378001773 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 469378001774 generic binding surface II; other site 469378001775 ssDNA binding site; other site 469378001776 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 469378001777 ATP binding site [chemical binding]; other site 469378001778 putative Mg++ binding site [ion binding]; other site 469378001779 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 469378001780 nucleotide binding region [chemical binding]; other site 469378001781 ATP-binding site [chemical binding]; other site 469378001782 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 469378001783 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469378001784 S-adenosylmethionine binding site [chemical binding]; other site 469378001785 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 469378001786 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 469378001787 active site 469378001788 (T/H)XGH motif; other site 469378001789 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469378001790 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 469378001791 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 469378001792 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 469378001793 putative phosphate acyltransferase; Provisional; Region: PRK05331 469378001794 ribonuclease III; Reviewed; Region: rnc; PRK00102 469378001795 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 469378001796 dimerization interface [polypeptide binding]; other site 469378001797 active site 469378001798 metal binding site [ion binding]; metal-binding site 469378001799 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 469378001800 dsRNA binding site [nucleotide binding]; other site 469378001801 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 469378001802 AAA domain; Region: AAA_23; pfam13476 469378001803 Walker A/P-loop; other site 469378001804 ATP binding site [chemical binding]; other site 469378001805 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 469378001806 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 469378001807 ABC transporter signature motif; other site 469378001808 Walker B; other site 469378001809 D-loop; other site 469378001810 H-loop/switch region; other site 469378001811 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 469378001812 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 469378001813 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 469378001814 P loop; other site 469378001815 GTP binding site [chemical binding]; other site 469378001816 signal recognition particle protein; Provisional; Region: PRK10867 469378001817 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 469378001818 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 469378001819 P loop; other site 469378001820 GTP binding site [chemical binding]; other site 469378001821 Signal peptide binding domain; Region: SRP_SPB; pfam02978 469378001822 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 469378001823 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 469378001824 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 469378001825 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 469378001826 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 469378001827 23S rRNA binding site [nucleotide binding]; other site 469378001828 L21 binding site [polypeptide binding]; other site 469378001829 L13 binding site [polypeptide binding]; other site 469378001830 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 469378001831 helicase 45; Provisional; Region: PTZ00424 469378001832 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 469378001833 ATP binding site [chemical binding]; other site 469378001834 Mg++ binding site [ion binding]; other site 469378001835 motif III; other site 469378001836 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 469378001837 nucleotide binding region [chemical binding]; other site 469378001838 ATP-binding site [chemical binding]; other site 469378001839 Transcriptional regulators [Transcription]; Region: MarR; COG1846 469378001840 MarR family; Region: MarR_2; pfam12802 469378001841 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 469378001842 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 469378001843 active site 469378001844 metal-binding site 469378001845 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 469378001846 Phosphotransferase enzyme family; Region: APH; pfam01636 469378001847 active site 469378001848 ATP binding site [chemical binding]; other site 469378001849 substrate binding site [chemical binding]; other site 469378001850 dimer interface [polypeptide binding]; other site 469378001851 ethanolamine utilization protein EutH; Provisional; Region: PRK15086 469378001852 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 469378001853 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 469378001854 NAD(P) binding site [chemical binding]; other site 469378001855 homodimer interface [polypeptide binding]; other site 469378001856 substrate binding site [chemical binding]; other site 469378001857 active site 469378001858 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 469378001859 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 469378001860 active site 469378001861 nucleotide binding site [chemical binding]; other site 469378001862 HIGH motif; other site 469378001863 KMSKS motif; other site 469378001864 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 469378001865 LicD family; Region: LicD; cl01378 469378001866 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 469378001867 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 469378001868 Ligand binding site; other site 469378001869 LicD family; Region: LicD; cl01378 469378001870 O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296 469378001871 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 469378001872 Chain length determinant protein; Region: Wzz; cl15801 469378001873 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 469378001874 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 469378001875 catalytic residue [active] 469378001876 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 469378001877 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 469378001878 active site 469378001879 nucleotide binding site [chemical binding]; other site 469378001880 HIGH motif; other site 469378001881 KMSKS motif; other site 469378001882 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 469378001883 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 469378001884 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 469378001885 active site 469378001886 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 469378001887 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 469378001888 putative ADP-binding pocket [chemical binding]; other site 469378001889 LicD family; Region: LicD; cl01378 469378001890 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 469378001891 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 469378001892 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 469378001893 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 469378001894 GTPase CgtA; Reviewed; Region: obgE; PRK12297 469378001895 GTP1/OBG; Region: GTP1_OBG; pfam01018 469378001896 Obg GTPase; Region: Obg; cd01898 469378001897 G1 box; other site 469378001898 GTP/Mg2+ binding site [chemical binding]; other site 469378001899 Switch I region; other site 469378001900 G2 box; other site 469378001901 G3 box; other site 469378001902 Switch II region; other site 469378001903 G4 box; other site 469378001904 G5 box; other site 469378001905 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 469378001906 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 469378001907 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 469378001908 active site 469378001909 (T/H)XGH motif; other site 469378001910 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 469378001911 Zn2+ binding site [ion binding]; other site 469378001912 Mg2+ binding site [ion binding]; other site 469378001913 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 469378001914 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 469378001915 TRAM domain; Region: TRAM; pfam01938 469378001916 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 469378001917 active site 469378001918 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 469378001919 binding surface 469378001920 TPR motif; other site 469378001921 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 469378001922 binding surface 469378001923 TPR motif; other site 469378001924 TPR repeat; Region: TPR_11; pfam13414 469378001925 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 469378001926 active site 469378001927 multimer interface [polypeptide binding]; other site 469378001928 rod shape-determining protein MreB; Provisional; Region: PRK13927 469378001929 MreB and similar proteins; Region: MreB_like; cd10225 469378001930 nucleotide binding site [chemical binding]; other site 469378001931 Mg binding site [ion binding]; other site 469378001932 putative protofilament interaction site [polypeptide binding]; other site 469378001933 RodZ interaction site [polypeptide binding]; other site 469378001934 rod shape-determining protein MreC; Provisional; Region: PRK13922 469378001935 rod shape-determining protein MreC; Region: MreC; pfam04085 469378001936 rod shape-determining protein MreD; Region: MreD; cl01087 469378001937 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 469378001938 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 469378001939 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 469378001940 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 469378001941 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 469378001942 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 469378001943 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 469378001944 B12 binding site [chemical binding]; other site 469378001945 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 469378001946 FeS/SAM binding site; other site 469378001947 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 469378001948 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 469378001949 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 469378001950 FAD binding domain; Region: FAD_binding_4; pfam01565 469378001951 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 469378001952 L-aspartate oxidase; Provisional; Region: PRK06175 469378001953 succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup; Region: sdhA_frdA_Gneg; TIGR01812 469378001954 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 469378001955 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479 469378001956 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 469378001957 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 469378001958 Cysteine-rich domain; Region: CCG; pfam02754 469378001959 Cysteine-rich domain; Region: CCG; pfam02754 469378001960 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 469378001961 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 469378001962 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 469378001963 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 469378001964 catalytic site [active] 469378001965 putative active site [active] 469378001966 putative substrate binding site [chemical binding]; other site 469378001967 HRDC domain; Region: HRDC; pfam00570 469378001968 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 469378001969 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 469378001970 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 469378001971 generic binding surface II; other site 469378001972 generic binding surface I; other site 469378001973 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 469378001974 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 469378001975 nucleotide binding site/active site [active] 469378001976 HIT family signature motif; other site 469378001977 catalytic residue [active] 469378001978 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 469378001979 propionate/acetate kinase; Provisional; Region: PRK12379 469378001980 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 469378001981 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 469378001982 active site 469378001983 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 469378001984 active site 469378001985 DNA polymerase IV; Validated; Region: PRK02406 469378001986 DNA binding site [nucleotide binding] 469378001987 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 469378001988 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 469378001989 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469378001990 homodimer interface [polypeptide binding]; other site 469378001991 catalytic residue [active] 469378001992 EDD domain protein, DegV family; Region: DegV; TIGR00762 469378001993 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 469378001994 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 469378001995 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 469378001996 active site 469378001997 HIGH motif; other site 469378001998 nucleotide binding site [chemical binding]; other site 469378001999 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 469378002000 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 469378002001 active site 469378002002 KMSKS motif; other site 469378002003 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 469378002004 tRNA binding surface [nucleotide binding]; other site 469378002005 anticodon binding site; other site 469378002006 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 469378002007 lipoprotein signal peptidase; Provisional; Region: PRK14787 469378002008 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 469378002009 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 469378002010 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 469378002011 RNA binding surface [nucleotide binding]; other site 469378002012 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 469378002013 active site 469378002014 Ferrochelatase; Region: Ferrochelatase; pfam00762 469378002015 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 469378002016 C-terminal domain interface [polypeptide binding]; other site 469378002017 active site 469378002018 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 469378002019 active site 469378002020 N-terminal domain interface [polypeptide binding]; other site 469378002021 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 469378002022 Flavoprotein; Region: Flavoprotein; pfam02441 469378002023 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 469378002024 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 469378002025 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 469378002026 active site 469378002027 catalytic site [active] 469378002028 substrate binding site [chemical binding]; other site 469378002029 M6 family metalloprotease domain; Region: M6dom_TIGR03296 469378002030 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 469378002031 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 469378002032 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 469378002033 putative ATP binding site [chemical binding]; other site 469378002034 putative substrate interface [chemical binding]; other site 469378002035 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 469378002036 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 469378002037 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 469378002038 RNA/DNA hybrid binding site [nucleotide binding]; other site 469378002039 active site 469378002040 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 469378002041 Na2 binding site [ion binding]; other site 469378002042 putative substrate binding site 1 [chemical binding]; other site 469378002043 Na binding site 1 [ion binding]; other site 469378002044 putative substrate binding site 2 [chemical binding]; other site 469378002045 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869 469378002046 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 469378002047 B3/4 domain; Region: B3_4; pfam03483 469378002048 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 469378002049 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 469378002050 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 469378002051 FMN binding site [chemical binding]; other site 469378002052 dimer interface [polypeptide binding]; other site 469378002053 Amidinotransferase; Region: Amidinotransf; cl12043 469378002054 ornithine carbamoyltransferase; Validated; Region: PRK02102 469378002055 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 469378002056 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 469378002057 carbamate kinase; Reviewed; Region: PRK12686 469378002058 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 469378002059 putative substrate binding site [chemical binding]; other site 469378002060 nucleotide binding site [chemical binding]; other site 469378002061 nucleotide binding site [chemical binding]; other site 469378002062 homodimer interface [polypeptide binding]; other site 469378002063 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 469378002064 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 469378002065 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 469378002066 active site 469378002067 HIGH motif; other site 469378002068 KMSK motif region; other site 469378002069 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 469378002070 tRNA binding surface [nucleotide binding]; other site 469378002071 anticodon binding site; other site 469378002072 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 469378002073 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 469378002074 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 469378002075 Na2 binding site [ion binding]; other site 469378002076 putative substrate binding site 1 [chemical binding]; other site 469378002077 Na binding site 1 [ion binding]; other site 469378002078 putative substrate binding site 2 [chemical binding]; other site 469378002079 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469378002080 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469378002081 active site 469378002082 phosphorylation site [posttranslational modification] 469378002083 intermolecular recognition site; other site 469378002084 dimerization interface [polypeptide binding]; other site 469378002085 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469378002086 DNA binding residues [nucleotide binding] 469378002087 dimerization interface [polypeptide binding]; other site 469378002088 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 469378002089 Histidine kinase; Region: HisKA_3; pfam07730 469378002090 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469378002091 ATP binding site [chemical binding]; other site 469378002092 Mg2+ binding site [ion binding]; other site 469378002093 G-X-G motif; other site 469378002094 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 469378002095 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 469378002096 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 469378002097 glutamate racemase; Provisional; Region: PRK00865 469378002098 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 469378002099 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 469378002100 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 469378002101 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469378002102 dimer interface [polypeptide binding]; other site 469378002103 conserved gate region; other site 469378002104 putative PBP binding loops; other site 469378002105 ABC-ATPase subunit interface; other site 469378002106 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 469378002107 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469378002108 dimer interface [polypeptide binding]; other site 469378002109 conserved gate region; other site 469378002110 putative PBP binding loops; other site 469378002111 ABC-ATPase subunit interface; other site 469378002112 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 469378002113 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469378002114 Walker A/P-loop; other site 469378002115 ATP binding site [chemical binding]; other site 469378002116 Q-loop/lid; other site 469378002117 ABC transporter signature motif; other site 469378002118 Walker B; other site 469378002119 D-loop; other site 469378002120 H-loop/switch region; other site 469378002121 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 469378002122 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 469378002123 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469378002124 Walker A/P-loop; other site 469378002125 ATP binding site [chemical binding]; other site 469378002126 Q-loop/lid; other site 469378002127 ABC transporter signature motif; other site 469378002128 Walker B; other site 469378002129 D-loop; other site 469378002130 H-loop/switch region; other site 469378002131 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 469378002132 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 469378002133 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 469378002134 inhibitor site; inhibition site 469378002135 active site 469378002136 dimer interface [polypeptide binding]; other site 469378002137 catalytic residue [active] 469378002138 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 469378002139 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 469378002140 nucleotide binding site [chemical binding]; other site 469378002141 Glucokinase; Region: Glucokinase; cl17310 469378002142 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 469378002143 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 469378002144 putative active site cavity [active] 469378002145 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 469378002146 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 469378002147 active site 469378002148 dimer interface [polypeptide binding]; other site 469378002149 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 469378002150 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 469378002151 active site 469378002152 trimer interface [polypeptide binding]; other site 469378002153 allosteric site; other site 469378002154 active site lid [active] 469378002155 hexamer (dimer of trimers) interface [polypeptide binding]; other site 469378002156 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 469378002157 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 469378002158 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 469378002159 ABC transporter; Region: ABC_tran_2; pfam12848 469378002160 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 469378002161 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 469378002162 Peptidase family M50; Region: Peptidase_M50; pfam02163 469378002163 active site 469378002164 putative substrate binding region [chemical binding]; other site 469378002165 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 469378002166 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 469378002167 active site 469378002168 HIGH motif; other site 469378002169 dimer interface [polypeptide binding]; other site 469378002170 KMSKS motif; other site 469378002171 ScpA/B protein; Region: ScpA_ScpB; cl00598 469378002172 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 469378002173 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 469378002174 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 469378002175 RNA binding surface [nucleotide binding]; other site 469378002176 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 469378002177 active site 469378002178 Prephenate dehydrogenase; Region: PDH; pfam02153 469378002179 prephenate dehydrogenase; Validated; Region: PRK08507 469378002180 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 469378002181 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 469378002182 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 469378002183 hinge; other site 469378002184 active site 469378002185 cytidylate kinase; Provisional; Region: cmk; PRK00023 469378002186 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 469378002187 CMP-binding site; other site 469378002188 The sites determining sugar specificity; other site 469378002189 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 469378002190 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 469378002191 putative acyl-acceptor binding pocket; other site 469378002192 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 469378002193 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 469378002194 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 469378002195 Protein of unknown function (DUF512); Region: DUF512; pfam04459 469378002196 GTP-binding protein Der; Reviewed; Region: PRK00093 469378002197 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 469378002198 G1 box; other site 469378002199 GTP/Mg2+ binding site [chemical binding]; other site 469378002200 Switch I region; other site 469378002201 G2 box; other site 469378002202 Switch II region; other site 469378002203 G3 box; other site 469378002204 G4 box; other site 469378002205 G5 box; other site 469378002206 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 469378002207 G1 box; other site 469378002208 GTP/Mg2+ binding site [chemical binding]; other site 469378002209 Switch I region; other site 469378002210 G2 box; other site 469378002211 G3 box; other site 469378002212 Switch II region; other site 469378002213 G4 box; other site 469378002214 G5 box; other site 469378002215 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 469378002216 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 469378002217 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 469378002218 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 469378002219 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 469378002220 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 469378002221 DNA binding site [nucleotide binding] 469378002222 active site 469378002223 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 469378002224 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 469378002225 substrate binding site [chemical binding]; other site 469378002226 hexamer interface [polypeptide binding]; other site 469378002227 metal binding site [ion binding]; metal-binding site 469378002228 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 469378002229 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 469378002230 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 469378002231 catalytic residue [active] 469378002232 Uncharacterized conserved protein [Function unknown]; Region: COG0327 469378002233 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 469378002234 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 469378002235 Putative zinc ribbon domain; Region: DUF164; pfam02591 469378002236 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 469378002237 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 469378002238 Zn2+ binding site [ion binding]; other site 469378002239 Mg2+ binding site [ion binding]; other site 469378002240 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 469378002241 AzlC protein; Region: AzlC; pfam03591 469378002242 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 469378002243 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 469378002244 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 469378002245 RNA/DNA hybrid binding site [nucleotide binding]; other site 469378002246 active site 469378002247 hypothetical protein; Reviewed; Region: PRK12497 469378002248 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 469378002249 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 469378002250 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 469378002251 Walker A motif; other site 469378002252 ATP binding site [chemical binding]; other site 469378002253 Walker B motif; other site 469378002254 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 469378002255 DNA protecting protein DprA; Region: dprA; TIGR00732 469378002256 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 469378002257 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 469378002258 Glucose inhibited division protein A; Region: GIDA; pfam01134 469378002259 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 469378002260 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 469378002261 active site 469378002262 DNA binding site [nucleotide binding] 469378002263 Int/Topo IB signature motif; other site 469378002264 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 469378002265 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 469378002266 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 469378002267 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 469378002268 glutamate dehydrogenase; Provisional; Region: PRK09414 469378002269 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 469378002270 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 469378002271 NAD(P) binding site [chemical binding]; other site 469378002272 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 469378002273 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 469378002274 GIY-YIG motif/motif A; other site 469378002275 active site 469378002276 catalytic site [active] 469378002277 putative DNA binding site [nucleotide binding]; other site 469378002278 metal binding site [ion binding]; metal-binding site 469378002279 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 469378002280 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 469378002281 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 469378002282 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 469378002283 phosphate binding site [ion binding]; other site 469378002284 putative substrate binding pocket [chemical binding]; other site 469378002285 dimer interface [polypeptide binding]; other site 469378002286 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 469378002287 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 469378002288 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 469378002289 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 469378002290 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 469378002291 Phosphoglycerate kinase; Region: PGK; pfam00162 469378002292 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 469378002293 substrate binding site [chemical binding]; other site 469378002294 hinge regions; other site 469378002295 ADP binding site [chemical binding]; other site 469378002296 catalytic site [active] 469378002297 triosephosphate isomerase; Provisional; Region: PRK14567 469378002298 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 469378002299 substrate binding site [chemical binding]; other site 469378002300 dimer interface [polypeptide binding]; other site 469378002301 catalytic triad [active] 469378002302 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 469378002303 phosphoglyceromutase; Provisional; Region: PRK05434 469378002304 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 469378002305 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 469378002306 NADH dehydrogenase; Region: NADHdh; cl00469 469378002307 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 469378002308 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 469378002309 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 469378002310 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 469378002311 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 469378002312 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 469378002313 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 469378002314 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 469378002315 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 469378002316 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 469378002317 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 469378002318 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 469378002319 phosphopeptide binding site; other site 469378002320 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 469378002321 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 469378002322 active site 469378002323 HIGH motif; other site 469378002324 nucleotide binding site [chemical binding]; other site 469378002325 active site 469378002326 KMSKS motif; other site 469378002327 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 469378002328 catalytic triad [active] 469378002329 active site nucleophile [active] 469378002330 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 469378002331 UbiA prenyltransferase family; Region: UbiA; pfam01040 469378002332 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 469378002333 UDP-glucose 4-epimerase; Region: PLN02240 469378002334 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 469378002335 NAD binding site [chemical binding]; other site 469378002336 homodimer interface [polypeptide binding]; other site 469378002337 active site 469378002338 substrate binding site [chemical binding]; other site 469378002339 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 469378002340 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 469378002341 active site 469378002342 substrate binding site [chemical binding]; other site 469378002343 metal binding site [ion binding]; metal-binding site 469378002344 Biotin operon repressor [Transcription]; Region: BirA; COG1654 469378002345 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 469378002346 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 469378002347 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 469378002348 trimer interface [polypeptide binding]; other site 469378002349 active site 469378002350 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 469378002351 ATP cone domain; Region: ATP-cone; pfam03477 469378002352 LexA repressor; Validated; Region: PRK00215 469378002353 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 469378002354 putative DNA binding site [nucleotide binding]; other site 469378002355 putative Zn2+ binding site [ion binding]; other site 469378002356 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 469378002357 Catalytic site [active] 469378002358 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 469378002359 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 469378002360 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 469378002361 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 469378002362 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 469378002363 FeS/SAM binding site; other site 469378002364 TRAM domain; Region: TRAM; cl01282 469378002365 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 469378002366 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469378002367 ATP binding site [chemical binding]; other site 469378002368 Mg2+ binding site [ion binding]; other site 469378002369 G-X-G motif; other site 469378002370 phosphodiesterase; Provisional; Region: PRK12704 469378002371 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 469378002372 Zn2+ binding site [ion binding]; other site 469378002373 Mg2+ binding site [ion binding]; other site 469378002374 recombination regulator RecX; Reviewed; Region: recX; PRK00117 469378002375 recombinase A; Provisional; Region: recA; PRK09354 469378002376 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 469378002377 hexamer interface [polypeptide binding]; other site 469378002378 Walker A motif; other site 469378002379 ATP binding site [chemical binding]; other site 469378002380 Walker B motif; other site 469378002381 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 469378002382 Competence-damaged protein; Region: CinA; pfam02464 469378002383 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 469378002384 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 469378002385 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 469378002386 FeS/SAM binding site; other site 469378002387 TRAM domain; Region: TRAM; cl01282 469378002388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 469378002389 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 469378002390 Helix-turn-helix domain; Region: HTH_25; pfam13413 469378002391 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 469378002392 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 469378002393 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 469378002394 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 469378002395 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 469378002396 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 469378002397 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 469378002398 dihydrodipicolinate synthase; Region: dapA; TIGR00674 469378002399 dimer interface [polypeptide binding]; other site 469378002400 active site 469378002401 catalytic residue [active] 469378002402 dihydrodipicolinate reductase; Provisional; Region: PRK00048 469378002403 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 469378002404 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 469378002405 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 469378002406 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 469378002407 RNase E interface [polypeptide binding]; other site 469378002408 trimer interface [polypeptide binding]; other site 469378002409 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 469378002410 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 469378002411 RNase E interface [polypeptide binding]; other site 469378002412 trimer interface [polypeptide binding]; other site 469378002413 active site 469378002414 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 469378002415 putative nucleic acid binding region [nucleotide binding]; other site 469378002416 G-X-X-G motif; other site 469378002417 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 469378002418 RNA binding site [nucleotide binding]; other site 469378002419 domain interface; other site 469378002420 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 469378002421 16S/18S rRNA binding site [nucleotide binding]; other site 469378002422 S13e-L30e interaction site [polypeptide binding]; other site 469378002423 25S rRNA binding site [nucleotide binding]; other site 469378002424 Recombination protein O N terminal; Region: RecO_N; pfam11967 469378002425 DNA repair protein RecO; Region: reco; TIGR00613 469378002426 Recombination protein O C terminal; Region: RecO_C; pfam02565 469378002427 GTPase Era; Reviewed; Region: era; PRK00089 469378002428 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 469378002429 G1 box; other site 469378002430 GTP/Mg2+ binding site [chemical binding]; other site 469378002431 Switch I region; other site 469378002432 G2 box; other site 469378002433 Switch II region; other site 469378002434 G3 box; other site 469378002435 G4 box; other site 469378002436 G5 box; other site 469378002437 KH domain; Region: KH_2; pfam07650 469378002438 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 469378002439 metal-binding heat shock protein; Provisional; Region: PRK00016 469378002440 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 469378002441 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 469378002442 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 469378002443 FeS/SAM binding site; other site 469378002444 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 469378002445 RNA methyltransferase, RsmE family; Region: TIGR00046 469378002446 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 469378002447 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 469378002448 HSP70 interaction site [polypeptide binding]; other site 469378002449 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 469378002450 Zn binding sites [ion binding]; other site 469378002451 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 469378002452 dimer interface [polypeptide binding]; other site 469378002453 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 469378002454 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 469378002455 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 469378002456 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 469378002457 FeS/SAM binding site; other site 469378002458 HemN C-terminal domain; Region: HemN_C; pfam06969 469378002459 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 469378002460 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 469378002461 FMN binding site [chemical binding]; other site 469378002462 active site 469378002463 catalytic residues [active] 469378002464 substrate binding site [chemical binding]; other site 469378002465 GTP-binding protein LepA; Provisional; Region: PRK05433 469378002466 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 469378002467 G1 box; other site 469378002468 putative GEF interaction site [polypeptide binding]; other site 469378002469 GTP/Mg2+ binding site [chemical binding]; other site 469378002470 Switch I region; other site 469378002471 G2 box; other site 469378002472 G3 box; other site 469378002473 Switch II region; other site 469378002474 G4 box; other site 469378002475 G5 box; other site 469378002476 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 469378002477 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 469378002478 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 469378002479 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 469378002480 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 469378002481 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 469378002482 Competence protein; Region: Competence; pfam03772 469378002483 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 469378002484 SLBB domain; Region: SLBB; pfam10531 469378002485 Helix-hairpin-helix motif; Region: HHH; pfam00633 469378002486 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 469378002487 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 469378002488 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 469378002489 Ligand Binding Site [chemical binding]; other site 469378002490 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 469378002491 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 469378002492 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 469378002493 catalytic site [active] 469378002494 G-X2-G-X-G-K; other site 469378002495 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 469378002496 active site 469378002497 dimer interface [polypeptide binding]; other site 469378002498 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 469378002499 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 469378002500 heterodimer interface [polypeptide binding]; other site 469378002501 active site 469378002502 FMN binding site [chemical binding]; other site 469378002503 homodimer interface [polypeptide binding]; other site 469378002504 substrate binding site [chemical binding]; other site 469378002505 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 469378002506 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 469378002507 FAD binding pocket [chemical binding]; other site 469378002508 FAD binding motif [chemical binding]; other site 469378002509 phosphate binding motif [ion binding]; other site 469378002510 beta-alpha-beta structure motif; other site 469378002511 NAD binding pocket [chemical binding]; other site 469378002512 Iron coordination center [ion binding]; other site 469378002513 dihydroorotase; Validated; Region: pyrC; PRK09357 469378002514 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 469378002515 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 469378002516 active site 469378002517 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 469378002518 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 469378002519 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 469378002520 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 469378002521 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 469378002522 active site 469378002523 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 469378002524 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 469378002525 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 469378002526 TPP-binding site [chemical binding]; other site 469378002527 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 469378002528 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 469378002529 dimer interface [polypeptide binding]; other site 469378002530 PYR/PP interface [polypeptide binding]; other site 469378002531 TPP binding site [chemical binding]; other site 469378002532 substrate binding site [chemical binding]; other site 469378002533 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 469378002534 4Fe-4S binding domain; Region: Fer4; cl02805 469378002535 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 469378002536 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 469378002537 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 469378002538 non-specific DNA binding site [nucleotide binding]; other site 469378002539 salt bridge; other site 469378002540 sequence-specific DNA binding site [nucleotide binding]; other site 469378002541 Cupin domain; Region: Cupin_2; pfam07883 469378002542 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 469378002543 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 469378002544 acyl-activating enzyme (AAE) consensus motif; other site 469378002545 AMP binding site [chemical binding]; other site 469378002546 active site 469378002547 CoA binding site [chemical binding]; other site 469378002548 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 469378002549 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 469378002550 putative active site [active] 469378002551 NusB family; Region: NusB; pfam01029 469378002552 putative RNA binding site [nucleotide binding]; other site 469378002553 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 469378002554 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 469378002555 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 469378002556 putative active site [active] 469378002557 substrate binding site [chemical binding]; other site 469378002558 putative cosubstrate binding site; other site 469378002559 catalytic site [active] 469378002560 Formyl transferase, C-terminal domain; Region: Formyl_trans_C; pfam02911 469378002561 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 469378002562 active site 469378002563 catalytic residues [active] 469378002564 metal binding site [ion binding]; metal-binding site 469378002565 DNA primase, catalytic core; Region: dnaG; TIGR01391 469378002566 CHC2 zinc finger; Region: zf-CHC2; pfam01807 469378002567 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 469378002568 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 469378002569 active site 469378002570 metal binding site [ion binding]; metal-binding site 469378002571 interdomain interaction site; other site 469378002572 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 469378002573 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 469378002574 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 469378002575 active site 469378002576 Riboflavin kinase; Region: Flavokinase; smart00904 469378002577 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 469378002578 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 469378002579 RNA binding site [nucleotide binding]; other site 469378002580 active site 469378002581 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 469378002582 DHH family; Region: DHH; pfam01368 469378002583 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 469378002584 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 469378002585 translation initiation factor IF-2; Region: IF-2; TIGR00487 469378002586 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 469378002587 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 469378002588 G1 box; other site 469378002589 putative GEF interaction site [polypeptide binding]; other site 469378002590 GTP/Mg2+ binding site [chemical binding]; other site 469378002591 Switch I region; other site 469378002592 G2 box; other site 469378002593 G3 box; other site 469378002594 Switch II region; other site 469378002595 G4 box; other site 469378002596 G5 box; other site 469378002597 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 469378002598 Translation-initiation factor 2; Region: IF-2; pfam11987 469378002599 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 469378002600 Protein of unknown function (DUF448); Region: DUF448; pfam04296 469378002601 putative RNA binding cleft [nucleotide binding]; other site 469378002602 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 469378002603 NusA N-terminal domain; Region: NusA_N; pfam08529 469378002604 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 469378002605 RNA binding site [nucleotide binding]; other site 469378002606 homodimer interface [polypeptide binding]; other site 469378002607 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 469378002608 G-X-X-G motif; other site 469378002609 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 469378002610 G-X-X-G motif; other site 469378002611 ribosome maturation protein RimP; Reviewed; Region: PRK00092 469378002612 Sm and related proteins; Region: Sm_like; cl00259 469378002613 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 469378002614 putative oligomer interface [polypeptide binding]; other site 469378002615 putative RNA binding site [nucleotide binding]; other site 469378002616 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 469378002617 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 469378002618 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 469378002619 Isochorismatase family; Region: Isochorismatase; pfam00857 469378002620 catalytic triad [active] 469378002621 conserved cis-peptide bond; other site 469378002622 Transposon-encoded protein TnpW; Region: TnpW; pfam14202 469378002623 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 469378002624 Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770 469378002625 putative catalytic residues [active] 469378002626 catalytic nucleophile [active] 469378002627 Recombinase; Region: Recombinase; pfam07508 469378002628 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 469378002629 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 469378002630 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 469378002631 Ferritin-like domain; Region: Ferritin; pfam00210 469378002632 dimerization interface [polypeptide binding]; other site 469378002633 DPS ferroxidase diiron center [ion binding]; other site 469378002634 ion pore; other site 469378002635 4Fe-4S binding domain; Region: Fer4_6; pfam12837 469378002636 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 469378002637 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 469378002638 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 469378002639 ABC transporter; Region: ABC_tran_2; pfam12848 469378002640 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 469378002641 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469378002642 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469378002643 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 469378002644 Mechanosensitive ion channel; Region: MS_channel; pfam00924 469378002645 DNA polymerase I; Provisional; Region: PRK05755 469378002646 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 469378002647 active site 469378002648 metal binding site 1 [ion binding]; metal-binding site 469378002649 putative 5' ssDNA interaction site; other site 469378002650 metal binding site 3; metal-binding site 469378002651 metal binding site 2 [ion binding]; metal-binding site 469378002652 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 469378002653 putative DNA binding site [nucleotide binding]; other site 469378002654 putative metal binding site [ion binding]; other site 469378002655 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 469378002656 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 469378002657 active site 469378002658 DNA binding site [nucleotide binding] 469378002659 catalytic site [active] 469378002660 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 469378002661 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 469378002662 DNA binding site [nucleotide binding] 469378002663 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 469378002664 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 469378002665 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 469378002666 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 469378002667 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 469378002668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469378002669 dimer interface [polypeptide binding]; other site 469378002670 conserved gate region; other site 469378002671 putative PBP binding loops; other site 469378002672 ABC-ATPase subunit interface; other site 469378002673 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 469378002674 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 469378002675 Walker A/P-loop; other site 469378002676 ATP binding site [chemical binding]; other site 469378002677 Q-loop/lid; other site 469378002678 ABC transporter signature motif; other site 469378002679 Walker B; other site 469378002680 D-loop; other site 469378002681 H-loop/switch region; other site 469378002682 Transcriptional regulator [Transcription]; Region: LytR; COG1316 469378002683 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 469378002684 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 469378002685 active site 469378002686 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 469378002687 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 469378002688 EamA-like transporter family; Region: EamA; pfam00892 469378002689 EamA-like transporter family; Region: EamA; pfam00892 469378002690 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 469378002691 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 469378002692 active site 469378002693 metal-binding site 469378002694 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 469378002695 Phosphotransferase enzyme family; Region: APH; pfam01636 469378002696 active site 469378002697 substrate binding site [chemical binding]; other site 469378002698 ATP binding site [chemical binding]; other site 469378002699 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 469378002700 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 469378002701 UDP-galactopyranose mutase; Region: GLF; pfam03275 469378002702 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 469378002703 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 469378002704 inhibitor-cofactor binding pocket; inhibition site 469378002705 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469378002706 catalytic residue [active] 469378002707 Bacterial sugar transferase; Region: Bac_transf; pfam02397 469378002708 2-ketoisovalerate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11864 469378002709 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 469378002710 TPP-binding site [chemical binding]; other site 469378002711 putative dimer interface [polypeptide binding]; other site 469378002712 pyruvate ferredoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK08367 469378002713 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 469378002714 dimer interface [polypeptide binding]; other site 469378002715 PYR/PP interface [polypeptide binding]; other site 469378002716 TPP binding site [chemical binding]; other site 469378002717 substrate binding site [chemical binding]; other site 469378002718 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 469378002719 pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional; Region: PRK14028 469378002720 4Fe-4S binding domain; Region: Fer4; pfam00037 469378002721 4Fe-4S binding domain; Region: Fer4; pfam00037 469378002722 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 469378002723 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 469378002724 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 469378002725 acyl-activating enzyme (AAE) consensus motif; other site 469378002726 AMP binding site [chemical binding]; other site 469378002727 active site 469378002728 CoA binding site [chemical binding]; other site 469378002729 Transcriptional regulator [Transcription]; Region: LysR; COG0583 469378002730 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 469378002731 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 469378002732 dimerization interface [polypeptide binding]; other site 469378002733 primosome assembly protein PriA; Validated; Region: PRK05580 469378002734 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 469378002735 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 469378002736 ATP binding site [chemical binding]; other site 469378002737 putative Mg++ binding site [ion binding]; other site 469378002738 helicase superfamily c-terminal domain; Region: HELICc; smart00490 469378002739 ATP-binding site [chemical binding]; other site 469378002740 S-adenosylmethionine synthetase; Validated; Region: PRK05250 469378002741 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 469378002742 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 469378002743 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 469378002744 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 469378002745 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 469378002746 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 469378002747 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 469378002748 HIGH motif; other site 469378002749 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 469378002750 active site 469378002751 KMSKS motif; other site 469378002752 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 469378002753 4Fe-4S binding domain; Region: Fer4; pfam00037 469378002754 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 469378002755 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 469378002756 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 469378002757 ATP binding site [chemical binding]; other site 469378002758 putative Mg++ binding site [ion binding]; other site 469378002759 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 469378002760 nucleotide binding region [chemical binding]; other site 469378002761 ATP-binding site [chemical binding]; other site 469378002762 TRCF domain; Region: TRCF; pfam03461 469378002763 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 469378002764 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 469378002765 minor groove reading motif; other site 469378002766 helix-hairpin-helix signature motif; other site 469378002767 substrate binding pocket [chemical binding]; other site 469378002768 active site 469378002769 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 469378002770 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 469378002771 catalytic residues [active] 469378002772 dimer interface [polypeptide binding]; other site 469378002773 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 469378002774 nickel binding site [ion binding]; other site 469378002775 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 469378002776 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 469378002777 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 469378002778 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 469378002779 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 469378002780 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 469378002781 Rubrerythrin [Energy production and conversion]; Region: COG1592 469378002782 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 469378002783 binuclear metal center [ion binding]; other site 469378002784 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 469378002785 iron binding site [ion binding]; other site 469378002786 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 469378002787 Prephenate dehydratase; Region: PDT; pfam00800 469378002788 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 469378002789 putative L-Phe binding site [chemical binding]; other site 469378002790 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 469378002791 endonuclease III; Region: ENDO3c; smart00478 469378002792 minor groove reading motif; other site 469378002793 helix-hairpin-helix signature motif; other site 469378002794 substrate binding pocket [chemical binding]; other site 469378002795 active site 469378002796 Predicted transcriptional regulator [Transcription]; Region: COG1959 469378002797 Transcriptional regulator; Region: Rrf2; pfam02082 469378002798 Transcriptional regulator; Region: Rrf2; cl17282 469378002799 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 469378002800 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 469378002801 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469378002802 Major Facilitator Superfamily; Region: MFS_1; pfam07690 469378002803 putative substrate translocation pore; other site 469378002804 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835 469378002805 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469378002806 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469378002807 DNA binding residues [nucleotide binding] 469378002808 dimerization interface [polypeptide binding]; other site 469378002809 Class I aldolases; Region: Aldolase_Class_I; cl17187 469378002810 catalytic residue [active] 469378002811 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 469378002812 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 469378002813 homodimer interface [polypeptide binding]; other site 469378002814 substrate-cofactor binding pocket; other site 469378002815 catalytic residue [active] 469378002816 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 469378002817 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 469378002818 acyl-activating enzyme (AAE) consensus motif; other site 469378002819 putative AMP binding site [chemical binding]; other site 469378002820 putative active site [active] 469378002821 putative CoA binding site [chemical binding]; other site 469378002822 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 469378002823 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 469378002824 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 469378002825 active site 469378002826 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 469378002827 CoA-transferase family III; Region: CoA_transf_3; pfam02515 469378002828 Transcriptional regulator [Transcription]; Region: LysR; COG0583 469378002829 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 469378002830 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 469378002831 dimerization interface [polypeptide binding]; other site 469378002832 Major Facilitator Superfamily; Region: MFS_1; pfam07690 469378002833 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469378002834 putative substrate translocation pore; other site 469378002835 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 469378002836 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 469378002837 active site 469378002838 ferredoxin-like protein FixX; Provisional; Region: PRK15449 469378002839 oxidoreductase; Provisional; Region: PRK10015 469378002840 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 469378002841 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 469378002842 Ligand Binding Site [chemical binding]; other site 469378002843 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 469378002844 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 469378002845 Ligand Binding Site [chemical binding]; other site 469378002846 Electron transfer flavoprotein domain; Region: ETF; pfam01012 469378002847 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 469378002848 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 469378002849 active site 469378002850 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 469378002851 2-isopropylmalate synthase; Validated; Region: PRK00915 469378002852 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 469378002853 active site 469378002854 catalytic residues [active] 469378002855 metal binding site [ion binding]; metal-binding site 469378002856 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 469378002857 ketol-acid reductoisomerase; Provisional; Region: PRK05479 469378002858 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 469378002859 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 469378002860 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 469378002861 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 469378002862 putative valine binding site [chemical binding]; other site 469378002863 dimer interface [polypeptide binding]; other site 469378002864 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 469378002865 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 469378002866 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 469378002867 PYR/PP interface [polypeptide binding]; other site 469378002868 dimer interface [polypeptide binding]; other site 469378002869 TPP binding site [chemical binding]; other site 469378002870 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 469378002871 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 469378002872 TPP-binding site [chemical binding]; other site 469378002873 dimer interface [polypeptide binding]; other site 469378002874 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 469378002875 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 469378002876 active site 469378002877 purine nucleoside phosphorylase; Provisional; Region: PRK08202 469378002878 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 469378002879 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 469378002880 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 469378002881 peptide chain release factor 1; Validated; Region: prfA; PRK00591 469378002882 This domain is found in peptide chain release factors; Region: PCRF; smart00937 469378002883 RF-1 domain; Region: RF-1; pfam00472 469378002884 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 469378002885 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 469378002886 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 469378002887 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 469378002888 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 469378002889 catalytic residues [active] 469378002890 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 469378002891 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 469378002892 active site 469378002893 nucleophile elbow; other site 469378002894 Peptidase C26; Region: Peptidase_C26; pfam07722 469378002895 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 469378002896 catalytic triad [active] 469378002897 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 469378002898 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 469378002899 Double zinc ribbon; Region: DZR; pfam12773 469378002900 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 469378002901 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 469378002902 active site 469378002903 HIGH motif; other site 469378002904 nucleotide binding site [chemical binding]; other site 469378002905 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 469378002906 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 469378002907 active site 469378002908 KMSKS motif; other site 469378002909 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 469378002910 tRNA binding surface [nucleotide binding]; other site 469378002911 anticodon binding site; other site 469378002912 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 469378002913 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 469378002914 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 469378002915 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 469378002916 Walker A motif; other site 469378002917 ATP binding site [chemical binding]; other site 469378002918 Walker B motif; other site 469378002919 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 469378002920 Clp protease; Region: CLP_protease; pfam00574 469378002921 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 469378002922 oligomer interface [polypeptide binding]; other site 469378002923 active site residues [active] 469378002924 trigger factor; Provisional; Region: tig; PRK01490 469378002925 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 469378002926 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 469378002927 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 469378002928 AMP-binding domain protein; Validated; Region: PRK08315 469378002929 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 469378002930 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 469378002931 acyl-activating enzyme (AAE) consensus motif; other site 469378002932 putative AMP binding site [chemical binding]; other site 469378002933 putative active site [active] 469378002934 putative CoA binding site [chemical binding]; other site 469378002935 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 469378002936 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 469378002937 non-specific DNA binding site [nucleotide binding]; other site 469378002938 salt bridge; other site 469378002939 sequence-specific DNA binding site [nucleotide binding]; other site 469378002940 Cupin domain; Region: Cupin_2; cl17218 469378002941 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 469378002942 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 469378002943 putative dimer interface [polypeptide binding]; other site 469378002944 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 469378002945 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 469378002946 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 469378002947 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 469378002948 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469378002949 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 469378002950 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 469378002951 DNA binding residues [nucleotide binding] 469378002952 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 469378002953 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 469378002954 FeS/SAM binding site; other site 469378002955 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 469378002956 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 469378002957 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 469378002958 EDD domain protein, DegV family; Region: DegV; TIGR00762 469378002959 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 469378002960 EDD domain protein, DegV family; Region: DegV; TIGR00762 469378002961 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 469378002962 EDD domain protein, DegV family; Region: DegV; TIGR00762 469378002963 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 469378002964 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 469378002965 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 469378002966 active site 469378002967 PSP1 C-terminal conserved region; Region: PSP1; cl00770 469378002968 DNA polymerase III subunit delta'; Validated; Region: PRK07940 469378002969 DNA polymerase III subunit delta'; Validated; Region: PRK08485 469378002970 thymidylate kinase; Validated; Region: tmk; PRK00698 469378002971 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 469378002972 TMP-binding site; other site 469378002973 ATP-binding site [chemical binding]; other site 469378002974 DNA topoisomerase I; Validated; Region: PRK07219 469378002975 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 469378002976 active site 469378002977 putative interdomain interaction site [polypeptide binding]; other site 469378002978 putative metal-binding site [ion binding]; other site 469378002979 putative nucleotide binding site [chemical binding]; other site 469378002980 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 469378002981 domain I; other site 469378002982 DNA binding groove [nucleotide binding] 469378002983 phosphate binding site [ion binding]; other site 469378002984 domain II; other site 469378002985 domain III; other site 469378002986 nucleotide binding site [chemical binding]; other site 469378002987 catalytic site [active] 469378002988 domain IV; other site 469378002989 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 469378002990 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 469378002991 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 469378002992 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 469378002993 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 469378002994 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469378002995 S-adenosylmethionine binding site [chemical binding]; other site 469378002996 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 469378002997 Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: MetG; COG0143 469378002998 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 469378002999 active site 469378003000 HIGH motif; other site 469378003001 nucleotide binding site [chemical binding]; other site 469378003002 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 469378003003 KMSKS motif; other site 469378003004 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 469378003005 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 469378003006 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 469378003007 tandem repeat interface [polypeptide binding]; other site 469378003008 oligomer interface [polypeptide binding]; other site 469378003009 active site residues [active] 469378003010 transcription termination factor Rho; Provisional; Region: rho; PRK09376 469378003011 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 469378003012 RNA binding site [nucleotide binding]; other site 469378003013 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 469378003014 multimer interface [polypeptide binding]; other site 469378003015 Walker A motif; other site 469378003016 ATP binding site [chemical binding]; other site 469378003017 Walker B motif; other site 469378003018 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 469378003019 active site 469378003020 intersubunit interactions; other site 469378003021 catalytic residue [active] 469378003022 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 469378003023 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 469378003024 active site 469378003025 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 469378003026 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 469378003027 dimer interface [polypeptide binding]; other site 469378003028 substrate binding site [chemical binding]; other site 469378003029 ATP binding site [chemical binding]; other site 469378003030 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 469378003031 thiamine phosphate binding site [chemical binding]; other site 469378003032 active site 469378003033 pyrophosphate binding site [ion binding]; other site 469378003034 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 469378003035 substrate binding site [chemical binding]; other site 469378003036 multimerization interface [polypeptide binding]; other site 469378003037 ATP binding site [chemical binding]; other site 469378003038 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 469378003039 Thiamine pyrophosphokinase; Region: TPK; cd07995 469378003040 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 469378003041 active site 469378003042 dimerization interface [polypeptide binding]; other site 469378003043 thiamine binding site [chemical binding]; other site 469378003044 Glucan-binding protein C; Region: GbpC; pfam08363 469378003045 DivIVA protein; Region: DivIVA; pfam05103 469378003046 DivIVA domain; Region: DivI1A_domain; TIGR03544 469378003047 YGGT family; Region: YGGT; pfam02325 469378003048 Protein of unknown function (DUF552); Region: DUF552; pfam04472 469378003049 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 469378003050 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 469378003051 catalytic residue [active] 469378003052 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 469378003053 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 469378003054 cell division protein FtsZ; Validated; Region: PRK09330 469378003055 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 469378003056 nucleotide binding site [chemical binding]; other site 469378003057 SulA interaction site; other site 469378003058 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 469378003059 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 469378003060 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 469378003061 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 469378003062 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 469378003063 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 469378003064 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 469378003065 active site 469378003066 homodimer interface [polypeptide binding]; other site 469378003067 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 469378003068 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 469378003069 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488 469378003070 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 469378003071 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 469378003072 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 469378003073 Mg++ binding site [ion binding]; other site 469378003074 putative catalytic motif [active] 469378003075 putative substrate binding site [chemical binding]; other site 469378003076 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 469378003077 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 469378003078 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 469378003079 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 469378003080 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 469378003081 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 469378003082 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 469378003083 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 469378003084 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 469378003085 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 469378003086 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 469378003087 MraW methylase family; Region: Methyltransf_5; pfam01795 469378003088 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 469378003089 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 469378003090 MraZ protein; Region: MraZ; pfam02381 469378003091 MraZ protein; Region: MraZ; pfam02381 469378003092 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 469378003093 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 469378003094 active site 469378003095 Int/Topo IB signature motif; other site 469378003096 CTP synthetase; Validated; Region: pyrG; PRK05380 469378003097 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 469378003098 Catalytic site [active] 469378003099 active site 469378003100 UTP binding site [chemical binding]; other site 469378003101 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 469378003102 active site 469378003103 putative oxyanion hole; other site 469378003104 catalytic triad [active] 469378003105 ATP-NAD kinase; Region: NAD_kinase; pfam01513 469378003106 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 469378003107 integral membrane protein MviN; Region: mviN; TIGR01695 469378003108 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 469378003109 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 469378003110 putative deacylase active site [active] 469378003111 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 469378003112 mRNA/rRNA interface [nucleotide binding]; other site 469378003113 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 469378003114 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 469378003115 23S rRNA interface [nucleotide binding]; other site 469378003116 L7/L12 interface [polypeptide binding]; other site 469378003117 putative thiostrepton binding site; other site 469378003118 L25 interface [polypeptide binding]; other site 469378003119 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 469378003120 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 469378003121 putative homodimer interface [polypeptide binding]; other site 469378003122 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 469378003123 heterodimer interface [polypeptide binding]; other site 469378003124 homodimer interface [polypeptide binding]; other site 469378003125 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 469378003126 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 469378003127 elongation factor Tu; Reviewed; Region: PRK00049 469378003128 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 469378003129 G1 box; other site 469378003130 GEF interaction site [polypeptide binding]; other site 469378003131 GTP/Mg2+ binding site [chemical binding]; other site 469378003132 Switch I region; other site 469378003133 G2 box; other site 469378003134 G3 box; other site 469378003135 Switch II region; other site 469378003136 G4 box; other site 469378003137 G5 box; other site 469378003138 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 469378003139 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 469378003140 Antibiotic Binding Site [chemical binding]; other site 469378003141 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 469378003142 Na binding site [ion binding]; other site 469378003143 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 469378003144 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 469378003145 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 469378003146 catalytic residue [active] 469378003147 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 469378003148 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 469378003149 dimer interface [polypeptide binding]; other site 469378003150 PYR/PP interface [polypeptide binding]; other site 469378003151 TPP binding site [chemical binding]; other site 469378003152 substrate binding site [chemical binding]; other site 469378003153 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 469378003154 Domain of unknown function; Region: EKR; pfam10371 469378003155 4Fe-4S binding domain; Region: Fer4_6; pfam12837 469378003156 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 469378003157 TPP-binding site [chemical binding]; other site 469378003158 dimer interface [polypeptide binding]; other site 469378003159 adenylate kinase; Reviewed; Region: adk; PRK00279 469378003160 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 469378003161 AMP-binding site [chemical binding]; other site 469378003162 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 469378003163 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 469378003164 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 469378003165 SecY translocase; Region: SecY; pfam00344 469378003166 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 469378003167 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 469378003168 23S rRNA binding site [nucleotide binding]; other site 469378003169 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 469378003170 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 469378003171 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 469378003172 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 469378003173 5S rRNA interface [nucleotide binding]; other site 469378003174 L27 interface [polypeptide binding]; other site 469378003175 23S rRNA interface [nucleotide binding]; other site 469378003176 L5 interface [polypeptide binding]; other site 469378003177 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 469378003178 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 469378003179 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 469378003180 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 469378003181 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 469378003182 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 469378003183 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 469378003184 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 469378003185 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 469378003186 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 469378003187 RNA binding site [nucleotide binding]; other site 469378003188 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 469378003189 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 469378003190 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 469378003191 23S rRNA interface [nucleotide binding]; other site 469378003192 putative translocon interaction site; other site 469378003193 signal recognition particle (SRP54) interaction site; other site 469378003194 L23 interface [polypeptide binding]; other site 469378003195 trigger factor interaction site; other site 469378003196 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 469378003197 23S rRNA interface [nucleotide binding]; other site 469378003198 5S rRNA interface [nucleotide binding]; other site 469378003199 putative antibiotic binding site [chemical binding]; other site 469378003200 L25 interface [polypeptide binding]; other site 469378003201 L27 interface [polypeptide binding]; other site 469378003202 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 469378003203 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 469378003204 G-X-X-G motif; other site 469378003205 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 469378003206 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 469378003207 putative translocon binding site; other site 469378003208 protein-rRNA interface [nucleotide binding]; other site 469378003209 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 469378003210 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 469378003211 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 469378003212 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 469378003213 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 469378003214 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 469378003215 hypothetical protein; Validated; Region: PRK07121 469378003216 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 469378003217 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 469378003218 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 469378003219 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 469378003220 elongation factor G; Reviewed; Region: PRK00007 469378003221 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 469378003222 G1 box; other site 469378003223 putative GEF interaction site [polypeptide binding]; other site 469378003224 GTP/Mg2+ binding site [chemical binding]; other site 469378003225 Switch I region; other site 469378003226 G2 box; other site 469378003227 G3 box; other site 469378003228 Switch II region; other site 469378003229 G4 box; other site 469378003230 G5 box; other site 469378003231 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 469378003232 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 469378003233 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 469378003234 30S ribosomal protein S7; Validated; Region: PRK05302 469378003235 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 469378003236 S17 interaction site [polypeptide binding]; other site 469378003237 S8 interaction site; other site 469378003238 16S rRNA interaction site [nucleotide binding]; other site 469378003239 streptomycin interaction site [chemical binding]; other site 469378003240 23S rRNA interaction site [nucleotide binding]; other site 469378003241 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 469378003242 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 469378003243 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 469378003244 ACT_3PGDH-like CD includes the C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-like; cd04879 469378003245 L-serine binding site [chemical binding]; other site 469378003246 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 469378003247 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 469378003248 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 469378003249 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 469378003250 Ligand Binding Site [chemical binding]; other site 469378003251 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 469378003252 DHH family; Region: DHH; pfam01368 469378003253 DHHA2 domain; Region: DHHA2; pfam02833 469378003254 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 469378003255 Part of AAA domain; Region: AAA_19; pfam13245 469378003256 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 469378003257 Family description; Region: UvrD_C_2; pfam13538 469378003258 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 469378003259 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 469378003260 Chorismate mutase type II; Region: CM_2; pfam01817 469378003261 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469378003262 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469378003263 DNA binding residues [nucleotide binding] 469378003264 dimerization interface [polypeptide binding]; other site 469378003265 FMN-binding domain; Region: FMN_bind; pfam04205 469378003266 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 469378003267 L-aspartate oxidase; Provisional; Region: PRK06175 469378003268 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 469378003269 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 469378003270 DNA binding site [nucleotide binding] 469378003271 active site 469378003272 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 469378003273 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 469378003274 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 469378003275 Walker A/P-loop; other site 469378003276 ATP binding site [chemical binding]; other site 469378003277 Q-loop/lid; other site 469378003278 ABC transporter signature motif; other site 469378003279 Walker B; other site 469378003280 D-loop; other site 469378003281 H-loop/switch region; other site 469378003282 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 469378003283 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 469378003284 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469378003285 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469378003286 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 469378003287 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 469378003288 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 469378003289 dimer interface [polypeptide binding]; other site 469378003290 putative functional site; other site 469378003291 putative MPT binding site; other site 469378003292 Predicted membrane protein [Function unknown]; Region: COG2323 469378003293 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 469378003294 Cupin domain; Region: Cupin_2; pfam07883 469378003295 GMP synthase; Reviewed; Region: guaA; PRK00074 469378003296 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 469378003297 AMP/PPi binding site [chemical binding]; other site 469378003298 candidate oxyanion hole; other site 469378003299 catalytic triad [active] 469378003300 potential glutamine specificity residues [chemical binding]; other site 469378003301 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 469378003302 ATP Binding subdomain [chemical binding]; other site 469378003303 Ligand Binding sites [chemical binding]; other site 469378003304 Dimerization subdomain; other site 469378003305 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 469378003306 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 469378003307 Walker A motif; other site 469378003308 ATP binding site [chemical binding]; other site 469378003309 Walker B motif; other site 469378003310 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 469378003311 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469378003312 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469378003313 WHG domain; Region: WHG; pfam13305 469378003314 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 469378003315 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 469378003316 Rrf2 family protein; Region: rrf2_super; TIGR00738 469378003317 Transcriptional regulator; Region: Rrf2; pfam02082 469378003318 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 469378003319 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 469378003320 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 469378003321 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469378003322 Walker A/P-loop; other site 469378003323 ATP binding site [chemical binding]; other site 469378003324 Q-loop/lid; other site 469378003325 ABC transporter signature motif; other site 469378003326 Walker B; other site 469378003327 D-loop; other site 469378003328 H-loop/switch region; other site 469378003329 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 469378003330 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 469378003331 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469378003332 Walker A/P-loop; other site 469378003333 ATP binding site [chemical binding]; other site 469378003334 Q-loop/lid; other site 469378003335 ABC transporter signature motif; other site 469378003336 Walker B; other site 469378003337 D-loop; other site 469378003338 H-loop/switch region; other site 469378003339 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 469378003340 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 469378003341 FAD binding domain; Region: FAD_binding_4; pfam01565 469378003342 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 469378003343 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 469378003344 active site 469378003345 catalytic tetrad [active] 469378003346 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 469378003347 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469378003348 active site 469378003349 phosphorylation site [posttranslational modification] 469378003350 intermolecular recognition site; other site 469378003351 dimerization interface [polypeptide binding]; other site 469378003352 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 469378003353 DNA binding site [nucleotide binding] 469378003354 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 469378003355 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 469378003356 dimerization interface [polypeptide binding]; other site 469378003357 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 469378003358 dimer interface [polypeptide binding]; other site 469378003359 phosphorylation site [posttranslational modification] 469378003360 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469378003361 ATP binding site [chemical binding]; other site 469378003362 Mg2+ binding site [ion binding]; other site 469378003363 G-X-G motif; other site 469378003364 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 469378003365 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 469378003366 substrate binding site; other site 469378003367 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 469378003368 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469378003369 NAD(P) binding site [chemical binding]; other site 469378003370 active site 469378003371 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 469378003372 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 469378003373 inhibitor-cofactor binding pocket; inhibition site 469378003374 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469378003375 catalytic residue [active] 469378003376 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 469378003377 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469378003378 NAD(P) binding site [chemical binding]; other site 469378003379 active site 469378003380 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 469378003381 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 469378003382 Ligand binding site; other site 469378003383 Putative Catalytic site; other site 469378003384 DXD motif; other site 469378003385 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 469378003386 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 469378003387 PYR/PP interface [polypeptide binding]; other site 469378003388 dimer interface [polypeptide binding]; other site 469378003389 TPP binding site [chemical binding]; other site 469378003390 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 469378003391 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 469378003392 TPP-binding site [chemical binding]; other site 469378003393 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 469378003394 endonuclease III; Region: ENDO3c; smart00478 469378003395 minor groove reading motif; other site 469378003396 helix-hairpin-helix signature motif; other site 469378003397 substrate binding pocket [chemical binding]; other site 469378003398 active site 469378003399 enolase; Provisional; Region: eno; PRK00077 469378003400 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 469378003401 dimer interface [polypeptide binding]; other site 469378003402 metal binding site [ion binding]; metal-binding site 469378003403 substrate binding pocket [chemical binding]; other site 469378003404 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cl00399 469378003405 hypothetical protein; Provisional; Region: PRK08262 469378003406 M20 Peptidase, carboxypeptidase yscS; Region: M20_yscS; cd05674 469378003407 metal binding site [ion binding]; metal-binding site 469378003408 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469378003409 Major Facilitator Superfamily; Region: MFS_1; pfam07690 469378003410 putative substrate translocation pore; other site 469378003411 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469378003412 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 469378003413 Q-loop/lid; other site 469378003414 ABC transporter signature motif; other site 469378003415 Walker B; other site 469378003416 D-loop; other site 469378003417 H-loop/switch region; other site 469378003418 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 469378003419 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 469378003420 intersubunit interface [polypeptide binding]; other site 469378003421 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 469378003422 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 469378003423 dimer interface [polypeptide binding]; other site 469378003424 phosphorylation site [posttranslational modification] 469378003425 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469378003426 ATP binding site [chemical binding]; other site 469378003427 Mg2+ binding site [ion binding]; other site 469378003428 G-X-G motif; other site 469378003429 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 469378003430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469378003431 active site 469378003432 phosphorylation site [posttranslational modification] 469378003433 intermolecular recognition site; other site 469378003434 dimerization interface [polypeptide binding]; other site 469378003435 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 469378003436 DNA binding site [nucleotide binding] 469378003437 HlyD family secretion protein; Region: HlyD_3; pfam13437 469378003438 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 469378003439 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 469378003440 Walker A/P-loop; other site 469378003441 ATP binding site [chemical binding]; other site 469378003442 Q-loop/lid; other site 469378003443 ABC transporter signature motif; other site 469378003444 Walker B; other site 469378003445 D-loop; other site 469378003446 H-loop/switch region; other site 469378003447 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 469378003448 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 469378003449 FtsX-like permease family; Region: FtsX; pfam02687 469378003450 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 469378003451 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 469378003452 homodimer interface [polypeptide binding]; other site 469378003453 active site 469378003454 TDP-binding site; other site 469378003455 acceptor substrate-binding pocket; other site 469378003456 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 469378003457 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 469378003458 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 469378003459 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 469378003460 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 469378003461 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 469378003462 NodB motif; other site 469378003463 active site 469378003464 catalytic site [active] 469378003465 metal binding site [ion binding]; metal-binding site 469378003466 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 469378003467 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469378003468 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469378003469 active site 469378003470 phosphorylation site [posttranslational modification] 469378003471 intermolecular recognition site; other site 469378003472 dimerization interface [polypeptide binding]; other site 469378003473 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469378003474 DNA binding residues [nucleotide binding] 469378003475 dimerization interface [polypeptide binding]; other site 469378003476 Histidine kinase; Region: HisKA_3; pfam07730 469378003477 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469378003478 ATP binding site [chemical binding]; other site 469378003479 Mg2+ binding site [ion binding]; other site 469378003480 G-X-G motif; other site 469378003481 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 469378003482 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 469378003483 Walker A/P-loop; other site 469378003484 ATP binding site [chemical binding]; other site 469378003485 Q-loop/lid; other site 469378003486 ABC transporter signature motif; other site 469378003487 Walker B; other site 469378003488 D-loop; other site 469378003489 H-loop/switch region; other site 469378003490 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 469378003491 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 469378003492 short chain dehydrogenase; Validated; Region: PRK06182 469378003493 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 469378003494 NADP binding site [chemical binding]; other site 469378003495 active site 469378003496 steroid binding site; other site 469378003497 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 469378003498 Helix-turn-helix domain; Region: HTH_17; pfam12728 469378003499 Fic family protein [Function unknown]; Region: COG3177 469378003500 Fic/DOC family; Region: Fic; pfam02661 469378003501 MucBP domain; Region: MucBP; pfam06458 469378003502 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469378003503 DNA-binding site [nucleotide binding]; DNA binding site 469378003504 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 469378003505 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 469378003506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469378003507 homodimer interface [polypeptide binding]; other site 469378003508 catalytic residue [active] 469378003509 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 469378003510 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 469378003511 active site 469378003512 multimer interface [polypeptide binding]; other site 469378003513 glutamine amidotransferase subunit PdxT; Provisional; Region: PRK13525 469378003514 conserved cys residue [active] 469378003515 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 469378003516 Peptidase family U32; Region: Peptidase_U32; pfam01136 469378003517 3-amino-5-hydroxybenoic acid synthesis related protein; Region: AHBA_synth_RP; TIGR01454 469378003518 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 469378003519 motif II; other site 469378003520 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 469378003521 ABC1 family; Region: ABC1; cl17513 469378003522 Uncharacterized conserved protein [Function unknown]; Region: COG3937 469378003523 prolyl-tRNA synthetase; Provisional; Region: PRK09194 469378003524 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 469378003525 dimer interface [polypeptide binding]; other site 469378003526 motif 1; other site 469378003527 active site 469378003528 motif 2; other site 469378003529 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 469378003530 putative deacylase active site [active] 469378003531 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 469378003532 active site 469378003533 motif 3; other site 469378003534 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 469378003535 anticodon binding site; other site 469378003536 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 469378003537 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 469378003538 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 469378003539 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 469378003540 active site 469378003541 Peptidase family M50; Region: Peptidase_M50; pfam02163 469378003542 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 469378003543 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 469378003544 putative substrate binding region [chemical binding]; other site 469378003545 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 469378003546 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 469378003547 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 469378003548 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 469378003549 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 469378003550 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 469378003551 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 469378003552 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 469378003553 catalytic residue [active] 469378003554 putative FPP diphosphate binding site; other site 469378003555 putative FPP binding hydrophobic cleft; other site 469378003556 dimer interface [polypeptide binding]; other site 469378003557 putative IPP diphosphate binding site; other site 469378003558 ribosome recycling factor; Reviewed; Region: frr; PRK00083 469378003559 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 469378003560 hinge region; other site 469378003561 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 469378003562 putative nucleotide binding site [chemical binding]; other site 469378003563 uridine monophosphate binding site [chemical binding]; other site 469378003564 homohexameric interface [polypeptide binding]; other site 469378003565 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 469378003566 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 469378003567 protein binding site [polypeptide binding]; other site 469378003568 MOSC domain; Region: MOSC; pfam03473 469378003569 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 469378003570 ArsC family; Region: ArsC; pfam03960 469378003571 putative ArsC-like catalytic residues; other site 469378003572 putative TRX-like catalytic residues [active] 469378003573 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 469378003574 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 469378003575 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 469378003576 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 469378003577 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 469378003578 ABC transporter; Region: ABC_tran_2; pfam12848 469378003579 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 469378003580 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 469378003581 serine O-acetyltransferase; Region: cysE; TIGR01172 469378003582 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 469378003583 trimer interface [polypeptide binding]; other site 469378003584 active site 469378003585 substrate binding site [chemical binding]; other site 469378003586 CoA binding site [chemical binding]; other site 469378003587 Permease family; Region: Xan_ur_permease; pfam00860 469378003588 Predicted membrane protein [Function unknown]; Region: COG1511 469378003589 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 469378003590 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 469378003591 Predicted membrane protein [Function unknown]; Region: COG1511 469378003592 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 469378003593 Perilipin family; Region: Perilipin; pfam03036 469378003594 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 469378003595 Histone acetyltransferase [Transcription / Chromatin structure and dynamics]; Region: ELP3; COG1243 469378003596 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 469378003597 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 469378003598 Cl binding site [ion binding]; other site 469378003599 oligomer interface [polypeptide binding]; other site 469378003600 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 469378003601 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 469378003602 S-ribosylhomocysteinase; Provisional; Region: PRK02260 469378003603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469378003604 putative substrate translocation pore; other site 469378003605 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469378003606 FOG: CBS domain [General function prediction only]; Region: COG0517 469378003607 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 469378003608 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 469378003609 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 469378003610 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 469378003611 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 469378003612 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 469378003613 dimer interface [polypeptide binding]; other site 469378003614 active site 469378003615 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 469378003616 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 469378003617 NAD(P) binding site [chemical binding]; other site 469378003618 homotetramer interface [polypeptide binding]; other site 469378003619 homodimer interface [polypeptide binding]; other site 469378003620 active site 469378003621 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 469378003622 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 469378003623 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 469378003624 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 469378003625 FMN binding site [chemical binding]; other site 469378003626 substrate binding site [chemical binding]; other site 469378003627 putative catalytic residue [active] 469378003628 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 469378003629 MarR family; Region: MarR; pfam01047 469378003630 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 469378003631 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 469378003632 dimer interface [polypeptide binding]; other site 469378003633 active site 469378003634 CoA binding pocket [chemical binding]; other site 469378003635 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 469378003636 EamA-like transporter family; Region: EamA; pfam00892 469378003637 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 469378003638 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 469378003639 Na binding site [ion binding]; other site 469378003640 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 469378003641 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 469378003642 metal-binding site [ion binding] 469378003643 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 469378003644 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 469378003645 motif II; other site 469378003646 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 469378003647 metal-binding site [ion binding] 469378003648 C-terminal domain of Faecalibacterium prausnitzii A2-165 FrmR , and related domains; this domain family was previously known as part of DUF156; Region: FpFrmR-Cterm-like_DUF156; cd10156 469378003649 putative homodimer interface [polypeptide binding]; other site 469378003650 putative homotetramer interface [polypeptide binding]; other site 469378003651 putative allosteric switch controlling residues; other site 469378003652 putative metal binding site [ion binding]; other site 469378003653 putative homodimer-homodimer interface [polypeptide binding]; other site 469378003654 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 469378003655 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 469378003656 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 469378003657 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 469378003658 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 469378003659 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 469378003660 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 469378003661 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 469378003662 molybdopterin cofactor binding site; other site 469378003663 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 469378003664 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 469378003665 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 469378003666 molybdopterin cofactor binding site; other site 469378003667 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 469378003668 dimerization interface [polypeptide binding]; other site 469378003669 putative ATP binding site [chemical binding]; other site 469378003670 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 469378003671 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 469378003672 non-specific DNA binding site [nucleotide binding]; other site 469378003673 salt bridge; other site 469378003674 sequence-specific DNA binding site [nucleotide binding]; other site 469378003675 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 469378003676 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 469378003677 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 469378003678 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 469378003679 CPxP motif; other site 469378003680 DsrE/DsrF-like family; Region: DrsE; pfam02635 469378003681 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 469378003682 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 469378003683 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 469378003684 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 469378003685 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 469378003686 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 469378003687 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 469378003688 selenocysteine synthase; Provisional; Region: PRK04311 469378003689 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 469378003690 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 469378003691 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 469378003692 G1 box; other site 469378003693 GTPases - translation elongation factors [Translation, ribosomal structure and biogenesis]; Region: TufB; COG0050 469378003694 putative GEF interaction site [polypeptide binding]; other site 469378003695 GTP/Mg2+ binding site [chemical binding]; other site 469378003696 Switch I region; other site 469378003697 G2 box; other site 469378003698 G3 box; other site 469378003699 Switch II region; other site 469378003700 G4 box; other site 469378003701 G5 box; other site 469378003702 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 469378003703 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 469378003704 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 469378003705 Flavodoxin domain; Region: Flavodoxin_3; pfam12641 469378003706 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 469378003707 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 469378003708 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 469378003709 hypothetical protein; Provisional; Region: PRK13663 469378003710 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 469378003711 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469378003712 Walker A/P-loop; other site 469378003713 ATP binding site [chemical binding]; other site 469378003714 Q-loop/lid; other site 469378003715 ABC transporter signature motif; other site 469378003716 Walker B; other site 469378003717 D-loop; other site 469378003718 H-loop/switch region; other site 469378003719 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 469378003720 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 469378003721 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 469378003722 coproporphyrinogen III oxidase; Provisional; Region: PRK08629 469378003723 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 469378003724 FeS/SAM binding site; other site 469378003725 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 469378003726 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 469378003727 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 469378003728 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 469378003729 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 469378003730 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 469378003731 GDP-binding site [chemical binding]; other site 469378003732 ACT binding site; other site 469378003733 IMP binding site; other site 469378003734 replicative DNA helicase; Region: DnaB; TIGR00665 469378003735 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 469378003736 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 469378003737 Walker A motif; other site 469378003738 ATP binding site [chemical binding]; other site 469378003739 Walker B motif; other site 469378003740 DNA binding loops [nucleotide binding] 469378003741 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 469378003742 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 469378003743 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 469378003744 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 469378003745 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 469378003746 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 469378003747 dimer interface [polypeptide binding]; other site 469378003748 ssDNA binding site [nucleotide binding]; other site 469378003749 tetramer (dimer of dimers) interface [polypeptide binding]; other site 469378003750 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 469378003751 SurA N-terminal domain; Region: SurA_N; pfam09312 469378003752 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 469378003753 hypothetical protein; Validated; Region: PRK00194 469378003754 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 469378003755 homodecamer interface [polypeptide binding]; other site 469378003756 GTP cyclohydrolase I; Provisional; Region: PLN03044 469378003757 active site 469378003758 putative catalytic site residues [active] 469378003759 zinc binding site [ion binding]; other site 469378003760 GTP-CH-I/GFRP interaction surface; other site 469378003761 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 469378003762 active site 469378003763 putative catalytic site [active] 469378003764 DNA binding site [nucleotide binding] 469378003765 putative phosphate binding site [ion binding]; other site 469378003766 metal binding site A [ion binding]; metal-binding site 469378003767 AP binding site [nucleotide binding]; other site 469378003768 metal binding site B [ion binding]; metal-binding site 469378003769 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 469378003770 L-aspartate oxidase; Provisional; Region: PRK06175 469378003771 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 469378003772 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 469378003773 active site 469378003774 ATP binding site [chemical binding]; other site 469378003775 substrate binding site [chemical binding]; other site 469378003776 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 469378003777 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 469378003778 dimerization interface [polypeptide binding]; other site 469378003779 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 469378003780 dimer interface [polypeptide binding]; other site 469378003781 phosphorylation site [posttranslational modification] 469378003782 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469378003783 ATP binding site [chemical binding]; other site 469378003784 Mg2+ binding site [ion binding]; other site 469378003785 G-X-G motif; other site 469378003786 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 469378003787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469378003788 active site 469378003789 phosphorylation site [posttranslational modification] 469378003790 intermolecular recognition site; other site 469378003791 dimerization interface [polypeptide binding]; other site 469378003792 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 469378003793 DNA binding site [nucleotide binding] 469378003794 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 469378003795 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 469378003796 homodimer interface [polypeptide binding]; other site 469378003797 NAD binding pocket [chemical binding]; other site 469378003798 ATP binding pocket [chemical binding]; other site 469378003799 Mg binding site [ion binding]; other site 469378003800 active-site loop [active] 469378003801 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 469378003802 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 469378003803 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 469378003804 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 469378003805 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 469378003806 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 469378003807 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 469378003808 active site 469378003809 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 469378003810 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469378003811 S-adenosylmethionine binding site [chemical binding]; other site 469378003812 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 469378003813 Glycoprotease family; Region: Peptidase_M22; pfam00814 469378003814 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 469378003815 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 469378003816 Coenzyme A binding pocket [chemical binding]; other site 469378003817 UGMP family protein; Validated; Region: PRK09604 469378003818 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 469378003819 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 469378003820 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 469378003821 active site 469378003822 8-oxo-dGMP binding site [chemical binding]; other site 469378003823 nudix motif; other site 469378003824 metal binding site [ion binding]; metal-binding site 469378003825 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 469378003826 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 469378003827 putative tRNA-binding site [nucleotide binding]; other site 469378003828 B3/4 domain; Region: B3_4; pfam03483 469378003829 tRNA synthetase B5 domain; Region: B5; smart00874 469378003830 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 469378003831 dimer interface [polypeptide binding]; other site 469378003832 motif 1; other site 469378003833 motif 3; other site 469378003834 motif 2; other site 469378003835 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 469378003836 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 469378003837 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 469378003838 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 469378003839 dimer interface [polypeptide binding]; other site 469378003840 motif 1; other site 469378003841 active site 469378003842 motif 2; other site 469378003843 motif 3; other site 469378003844 T-box leader 469378003845 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 469378003846 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 469378003847 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469378003848 Walker A/P-loop; other site 469378003849 ATP binding site [chemical binding]; other site 469378003850 Q-loop/lid; other site 469378003851 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 469378003852 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 469378003853 ABC transporter signature motif; other site 469378003854 Walker B; other site 469378003855 D-loop; other site 469378003856 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469378003857 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 469378003858 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 469378003859 Walker A/P-loop; other site 469378003860 ATP binding site [chemical binding]; other site 469378003861 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 469378003862 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 469378003863 GatB domain; Region: GatB_Yqey; smart00845 469378003864 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 469378003865 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 469378003866 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 469378003867 EXLDI protein; Region: EXLDI; TIGR04342 469378003868 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 469378003869 Predicted integral membrane protein [Function unknown]; Region: COG5652 469378003870 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 469378003871 putative active site [active] 469378003872 GTP-binding protein YchF; Reviewed; Region: PRK09601 469378003873 YchF GTPase; Region: YchF; cd01900 469378003874 G1 box; other site 469378003875 GTP/Mg2+ binding site [chemical binding]; other site 469378003876 Switch I region; other site 469378003877 G2 box; other site 469378003878 Switch II region; other site 469378003879 G3 box; other site 469378003880 G4 box; other site 469378003881 G5 box; other site 469378003882 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 469378003883 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 469378003884 Na2 binding site [ion binding]; other site 469378003885 putative substrate binding site 1 [chemical binding]; other site 469378003886 Na binding site 1 [ion binding]; other site 469378003887 putative substrate binding site 2 [chemical binding]; other site 469378003888 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 469378003889 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 469378003890 active site 469378003891 dimer interface [polypeptide binding]; other site 469378003892 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 469378003893 Ligand Binding Site [chemical binding]; other site 469378003894 Molecular Tunnel; other site 469378003895 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 469378003896 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 469378003897 Ligand binding site; other site 469378003898 Putative Catalytic site; other site 469378003899 DXD motif; other site 469378003900 Integral membrane protein S linking to the trans Golgi network; Region: SYS1; pfam09801 469378003901 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 469378003902 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 469378003903 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 469378003904 dimerization interface 3.5A [polypeptide binding]; other site 469378003905 active site 469378003906 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 469378003907 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 469378003908 active site 469378003909 PHP Thumb interface [polypeptide binding]; other site 469378003910 metal binding site [ion binding]; metal-binding site 469378003911 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 469378003912 generic binding surface II; other site 469378003913 generic binding surface I; other site 469378003914 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14736 469378003915 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 469378003916 gamma subunit interface [polypeptide binding]; other site 469378003917 epsilon subunit interface [polypeptide binding]; other site 469378003918 LBP interface [polypeptide binding]; other site 469378003919 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 469378003920 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 469378003921 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 469378003922 alpha subunit interaction interface [polypeptide binding]; other site 469378003923 Walker A motif; other site 469378003924 ATP binding site [chemical binding]; other site 469378003925 Walker B motif; other site 469378003926 inhibitor binding site; inhibition site 469378003927 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 469378003928 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 469378003929 core domain interface [polypeptide binding]; other site 469378003930 delta subunit interface [polypeptide binding]; other site 469378003931 epsilon subunit interface [polypeptide binding]; other site 469378003932 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 469378003933 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 469378003934 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 469378003935 beta subunit interaction interface [polypeptide binding]; other site 469378003936 Walker A motif; other site 469378003937 ATP binding site [chemical binding]; other site 469378003938 Walker B motif; other site 469378003939 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 469378003940 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 469378003941 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 469378003942 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 469378003943 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 469378003944 ATP synthase subunit C; Region: ATP-synt_C; cl00466 469378003945 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 469378003946 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 469378003947 active site 469378003948 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 469378003949 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 469378003950 dimer interface [polypeptide binding]; other site 469378003951 active site 469378003952 glycine-pyridoxal phosphate binding site [chemical binding]; other site 469378003953 folate binding site [chemical binding]; other site 469378003954 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 469378003955 glycerol kinase; Provisional; Region: glpK; PRK00047 469378003956 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 469378003957 N- and C-terminal domain interface [polypeptide binding]; other site 469378003958 active site 469378003959 MgATP binding site [chemical binding]; other site 469378003960 catalytic site [active] 469378003961 metal binding site [ion binding]; metal-binding site 469378003962 glycerol binding site [chemical binding]; other site 469378003963 homotetramer interface [polypeptide binding]; other site 469378003964 homodimer interface [polypeptide binding]; other site 469378003965 FBP binding site [chemical binding]; other site 469378003966 protein IIAGlc interface [polypeptide binding]; other site 469378003967 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 469378003968 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 469378003969 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 469378003970 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 469378003971 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 469378003972 flavoprotein, HI0933 family; Region: TIGR00275 469378003973 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 469378003974 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cl00018 469378003975 Desulfoferrodoxin; Region: Desulfoferrodox; pfam01880 469378003976 non-heme iron binding site [ion binding]; other site 469378003977 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 469378003978 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 469378003979 Transcriptional regulator [Transcription]; Region: LytR; COG1316 469378003980 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 469378003981 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 469378003982 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 469378003983 hinge; other site 469378003984 active site 469378003985 elongation factor Ts; Provisional; Region: tsf; PRK09377 469378003986 UBA/TS-N domain; Region: UBA; pfam00627 469378003987 Elongation factor TS; Region: EF_TS; pfam00889 469378003988 Elongation factor TS; Region: EF_TS; pfam00889 469378003989 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 469378003990 rRNA interaction site [nucleotide binding]; other site 469378003991 S8 interaction site; other site 469378003992 putative laminin-1 binding site; other site 469378003993 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 469378003994 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 469378003995 inhibitor-cofactor binding pocket; inhibition site 469378003996 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469378003997 catalytic residue [active] 469378003998 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 469378003999 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 469378004000 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 469378004001 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 469378004002 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 469378004003 FeS/SAM binding site; other site 469378004004 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 469378004005 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 469378004006 dimer interface [polypeptide binding]; other site 469378004007 active site 469378004008 Schiff base residues; other site 469378004009 putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054 469378004010 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 469378004011 FeS/SAM binding site; other site 469378004012 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 469378004013 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 469378004014 active site 469378004015 SAM binding site [chemical binding]; other site 469378004016 homodimer interface [polypeptide binding]; other site 469378004017 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 469378004018 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 469378004019 active site 469378004020 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 469378004021 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 469378004022 domain interfaces; other site 469378004023 active site 469378004024 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 469378004025 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 469378004026 tRNA; other site 469378004027 putative tRNA binding site [nucleotide binding]; other site 469378004028 putative NADP binding site [chemical binding]; other site 469378004029 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 469378004030 siroheme synthase, N-terminal domain; Region: cysG_Nterm; TIGR01470 469378004031 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 469378004032 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 469378004033 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 469378004034 substrate binding pocket [chemical binding]; other site 469378004035 membrane-bound complex binding site; other site 469378004036 hinge residues; other site 469378004037 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 469378004038 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 469378004039 active site 469378004040 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 469378004041 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 469378004042 C-terminal domain interface [polypeptide binding]; other site 469378004043 GSH binding site (G-site) [chemical binding]; other site 469378004044 dimer interface [polypeptide binding]; other site 469378004045 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 469378004046 active site 469378004047 dimerization interface [polypeptide binding]; other site 469378004048 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469378004049 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469378004050 hypothetical protein; Validated; Region: PRK07121 469378004051 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 469378004052 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 469378004053 putative catalytic site [active] 469378004054 putative metal binding site [ion binding]; other site 469378004055 putative phosphate binding site [ion binding]; other site 469378004056 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469378004057 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469378004058 DNA binding residues [nucleotide binding] 469378004059 dimerization interface [polypeptide binding]; other site 469378004060 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 469378004061 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 469378004062 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 469378004063 shikimate binding site; other site 469378004064 NAD(P) binding site [chemical binding]; other site 469378004065 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 469378004066 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 469378004067 active site 469378004068 catalytic residue [active] 469378004069 dimer interface [polypeptide binding]; other site 469378004070 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 469378004071 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 469378004072 Predicted membrane protein [Function unknown]; Region: COG3601 469378004073 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 469378004074 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 469378004075 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 469378004076 Walker A/P-loop; other site 469378004077 ATP binding site [chemical binding]; other site 469378004078 Q-loop/lid; other site 469378004079 ABC transporter signature motif; other site 469378004080 Walker B; other site 469378004081 D-loop; other site 469378004082 H-loop/switch region; other site 469378004083 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 469378004084 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 469378004085 Walker A/P-loop; other site 469378004086 ATP binding site [chemical binding]; other site 469378004087 Q-loop/lid; other site 469378004088 ABC transporter signature motif; other site 469378004089 Walker B; other site 469378004090 D-loop; other site 469378004091 H-loop/switch region; other site 469378004092 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 469378004093 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 469378004094 Protein export membrane protein; Region: SecD_SecF; cl14618 469378004095 Protein export membrane protein; Region: SecD_SecF; pfam02355 469378004096 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 469378004097 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 469378004098 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 469378004099 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 469378004100 motif II; other site 469378004101 Uncharacterized BCR, COG1636; Region: DUF208; cl17782 469378004102 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 469378004103 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 469378004104 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 469378004105 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 469378004106 Ligand Binding Site [chemical binding]; other site 469378004107 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 469378004108 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 469378004109 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 469378004110 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 469378004111 shikimate kinase; Reviewed; Region: aroK; PRK00131 469378004112 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 469378004113 ADP binding site [chemical binding]; other site 469378004114 magnesium binding site [ion binding]; other site 469378004115 putative shikimate binding site; other site 469378004116 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 469378004117 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 469378004118 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase [Lipid metabolism]; Region: IspE; COG1947 469378004119 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 469378004120 nucleoside/Zn binding site; other site 469378004121 dimer interface [polypeptide binding]; other site 469378004122 catalytic motif [active] 469378004123 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113 469378004124 dimer interface [polypeptide binding]; other site 469378004125 Citrate synthase; Region: Citrate_synt; pfam00285 469378004126 active site 469378004127 citrylCoA binding site [chemical binding]; other site 469378004128 oxalacetate/citrate binding site [chemical binding]; other site 469378004129 coenzyme A binding site [chemical binding]; other site 469378004130 catalytic triad [active] 469378004131 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 469378004132 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 469378004133 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 469378004134 Walker A/P-loop; other site 469378004135 ATP binding site [chemical binding]; other site 469378004136 Q-loop/lid; other site 469378004137 ABC transporter signature motif; other site 469378004138 Walker B; other site 469378004139 D-loop; other site 469378004140 H-loop/switch region; other site 469378004141 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 469378004142 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 469378004143 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 469378004144 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 469378004145 Walker A motif; other site 469378004146 ATP binding site [chemical binding]; other site 469378004147 Walker B motif; other site 469378004148 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 469378004149 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 469378004150 RuvA N terminal domain; Region: RuvA_N; pfam01330 469378004151 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 469378004152 active site 469378004153 putative DNA-binding cleft [nucleotide binding]; other site 469378004154 dimer interface [polypeptide binding]; other site 469378004155 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 469378004156 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 469378004157 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 469378004158 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 469378004159 trimerization site [polypeptide binding]; other site 469378004160 active site 469378004161 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 469378004162 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 469378004163 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 469378004164 catalytic residue [active] 469378004165 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 469378004166 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 469378004167 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 469378004168 FeS assembly protein SufB; Region: sufB; TIGR01980 469378004169 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 469378004170 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 469378004171 Walker A/P-loop; other site 469378004172 ATP binding site [chemical binding]; other site 469378004173 Q-loop/lid; other site 469378004174 ABC transporter signature motif; other site 469378004175 Walker B; other site 469378004176 D-loop; other site 469378004177 H-loop/switch region; other site 469378004178 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 469378004179 metal-binding site [ion binding] 469378004180 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 469378004181 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 469378004182 Soluble P-type ATPase [General function prediction only]; Region: COG4087 469378004183 ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615 469378004184 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 469378004185 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 469378004186 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 469378004187 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 469378004188 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 469378004189 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 469378004190 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 469378004191 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 469378004192 G1 box; other site 469378004193 GTP/Mg2+ binding site [chemical binding]; other site 469378004194 Switch I region; other site 469378004195 G2 box; other site 469378004196 G3 box; other site 469378004197 Switch II region; other site 469378004198 G4 box; other site 469378004199 G5 box; other site 469378004200 Protein of unknown function (DUF2457); Region: DUF2457; pfam10446 469378004201 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 469378004202 Nucleoside recognition; Region: Gate; pfam07670 469378004203 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 469378004204 Nucleoside recognition; Region: Gate; pfam07670 469378004205 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 469378004206 FeoA domain; Region: FeoA; pfam04023 469378004207 PemK-like protein; Region: PemK; pfam02452 469378004208 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 469378004209 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 469378004210 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 469378004211 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469378004212 catalytic residue [active] 469378004213 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 469378004214 Transcriptional regulator [Transcription]; Region: LysR; COG0583 469378004215 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 469378004216 TadE-like protein; Region: TadE; pfam07811 469378004217 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 469378004218 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 469378004219 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 469378004220 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 469378004221 ATP binding site [chemical binding]; other site 469378004222 Walker A motif; other site 469378004223 hexamer interface [polypeptide binding]; other site 469378004224 Walker B motif; other site 469378004225 AAA domain; Region: AAA_31; pfam13614 469378004226 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 469378004227 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 469378004228 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 469378004229 active site 469378004230 HIGH motif; other site 469378004231 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 469378004232 KMSKS motif; other site 469378004233 This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840 469378004234 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 469378004235 homotrimer interaction site [polypeptide binding]; other site 469378004236 zinc binding site [ion binding]; other site 469378004237 CDP-binding sites; other site 469378004238 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 469378004239 substrate binding site; other site 469378004240 dimer interface; other site 469378004241 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 469378004242 Clp amino terminal domain; Region: Clp_N; pfam02861 469378004243 Clp amino terminal domain; Region: Clp_N; pfam02861 469378004244 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 469378004245 Walker A motif; other site 469378004246 ATP binding site [chemical binding]; other site 469378004247 Walker B motif; other site 469378004248 arginine finger; other site 469378004249 UvrB/uvrC motif; Region: UVR; pfam02151 469378004250 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 469378004251 Walker A motif; other site 469378004252 ATP binding site [chemical binding]; other site 469378004253 Walker B motif; other site 469378004254 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 469378004255 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 469378004256 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 469378004257 dimer interface [polypeptide binding]; other site 469378004258 putative anticodon binding site; other site 469378004259 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 469378004260 motif 1; other site 469378004261 active site 469378004262 motif 2; other site 469378004263 motif 3; other site 469378004264 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 469378004265 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 469378004266 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 469378004267 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 469378004268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 469378004269 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 469378004270 NlpC/P60 family; Region: NLPC_P60; cl17555 469378004271 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 469378004272 NlpC/P60 family; Region: NLPC_P60; pfam00877 469378004273 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 469378004274 30S subunit binding site; other site 469378004275 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 469378004276 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 469378004277 Cl- selectivity filter; other site 469378004278 Cl- binding residues [ion binding]; other site 469378004279 pore gating glutamate residue; other site 469378004280 dimer interface [polypeptide binding]; other site 469378004281 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 469378004282 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469378004283 Walker A/P-loop; other site 469378004284 ATP binding site [chemical binding]; other site 469378004285 Q-loop/lid; other site 469378004286 ABC transporter signature motif; other site 469378004287 Walker B; other site 469378004288 D-loop; other site 469378004289 H-loop/switch region; other site 469378004290 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469378004291 dimer interface [polypeptide binding]; other site 469378004292 conserved gate region; other site 469378004293 putative PBP binding loops; other site 469378004294 ABC-ATPase subunit interface; other site 469378004295 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 469378004296 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 469378004297 substrate binding pocket [chemical binding]; other site 469378004298 membrane-bound complex binding site; other site 469378004299 hinge residues; other site 469378004300 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 469378004301 4Fe-4S binding domain; Region: Fer4; pfam00037 469378004302 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 469378004303 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 469378004304 Walker A motif; other site 469378004305 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 469378004306 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 469378004307 GTP binding site; other site 469378004308 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469378004309 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469378004310 DNA binding residues [nucleotide binding] 469378004311 dimerization interface [polypeptide binding]; other site 469378004312 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 469378004313 G1 box; other site 469378004314 GTP/Mg2+ binding site [chemical binding]; other site 469378004315 Switch I region; other site 469378004316 G2 box; other site 469378004317 G3 box; other site 469378004318 Switch II region; other site 469378004319 G4 box; other site 469378004320 G5 box; other site 469378004321 Cytochrome c552; Region: Cytochrom_C552; pfam02335 469378004322 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439 469378004323 heme-binding residues [chemical binding]; other site 469378004324 FMN-binding domain; Region: FMN_bind; cl01081 469378004325 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 469378004326 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 469378004327 Predicted oxidoreductase [General function prediction only]; Region: COG3573 469378004328 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469378004329 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469378004330 DNA binding residues [nucleotide binding] 469378004331 dimerization interface [polypeptide binding]; other site 469378004332 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 469378004333 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 469378004334 Predicted oxidoreductase [General function prediction only]; Region: COG3573 469378004335 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469378004336 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469378004337 DNA binding residues [nucleotide binding] 469378004338 dimerization interface [polypeptide binding]; other site 469378004339 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 469378004340 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 469378004341 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 469378004342 ATP binding site [chemical binding]; other site 469378004343 putative Mg++ binding site [ion binding]; other site 469378004344 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 469378004345 nucleotide binding region [chemical binding]; other site 469378004346 ATP-binding site [chemical binding]; other site 469378004347 heat shock protein 90; Provisional; Region: PRK05218 469378004348 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469378004349 ATP binding site [chemical binding]; other site 469378004350 Mg2+ binding site [ion binding]; other site 469378004351 G-X-G motif; other site 469378004352 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 469378004353 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 469378004354 active site 469378004355 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 469378004356 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 469378004357 Na2 binding site [ion binding]; other site 469378004358 putative substrate binding site 1 [chemical binding]; other site 469378004359 Na binding site 1 [ion binding]; other site 469378004360 putative substrate binding site 2 [chemical binding]; other site 469378004361 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 469378004362 Double zinc ribbon; Region: DZR; pfam12773 469378004363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469378004364 Major Facilitator Superfamily; Region: MFS_1; pfam07690 469378004365 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469378004366 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469378004367 DNA binding residues [nucleotide binding] 469378004368 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 469378004369 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 469378004370 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 469378004371 active site 469378004372 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 469378004373 active site 469378004374 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 469378004375 active site 2 [active] 469378004376 active site 1 [active] 469378004377 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 469378004378 putative active site pocket [active] 469378004379 dimerization interface [polypeptide binding]; other site 469378004380 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 469378004381 putative catalytic residue [active] 469378004382 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 469378004383 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 469378004384 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469378004385 DNA-binding site [nucleotide binding]; DNA binding site 469378004386 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 469378004387 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469378004388 homodimer interface [polypeptide binding]; other site 469378004389 catalytic residue [active] 469378004390 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 469378004391 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 469378004392 NAD(P) binding site [chemical binding]; other site 469378004393 catalytic residues [active] 469378004394 diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921 469378004395 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl17742 469378004396 FMN-binding domain; Region: FMN_bind; cl01081 469378004397 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 469378004398 L-aspartate oxidase; Provisional; Region: PRK06175 469378004399 L-aspartate oxidase; Provisional; Region: PRK06175 469378004400 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469378004401 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469378004402 DNA binding residues [nucleotide binding] 469378004403 dimerization interface [polypeptide binding]; other site 469378004404 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 469378004405 ligand binding site [chemical binding]; other site 469378004406 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 469378004407 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 469378004408 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 469378004409 4Fe-4S binding domain; Region: Fer4_6; pfam12837 469378004410 DMSO reductase family type II enzyme, molybdopterin subunit; Region: DMSO_red_II_alp; TIGR03479 469378004411 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 469378004412 molybdopterin cofactor binding site; other site 469378004413 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 469378004414 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 469378004415 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 469378004416 molybdopterin cofactor binding site; other site 469378004417 Methyltransferase domain; Region: Methyltransf_31; pfam13847 469378004418 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469378004419 S-adenosylmethionine binding site [chemical binding]; other site 469378004420 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 469378004421 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 469378004422 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 469378004423 dimerization interface [polypeptide binding]; other site 469378004424 ATP binding site [chemical binding]; other site 469378004425 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 469378004426 dimerization interface [polypeptide binding]; other site 469378004427 ATP binding site [chemical binding]; other site 469378004428 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 469378004429 conserved cys residue [active] 469378004430 Collagen binding domain; Region: Collagen_bind; pfam05737 469378004431 Cna protein B-type domain; Region: Cna_B; pfam05738 469378004432 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 469378004433 domain interaction interfaces [polypeptide binding]; other site 469378004434 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 469378004435 domain interaction interfaces [polypeptide binding]; other site 469378004436 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 469378004437 domain interaction interfaces [polypeptide binding]; other site 469378004438 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 469378004439 domain interaction interfaces [polypeptide binding]; other site 469378004440 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 469378004441 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 469378004442 Soluble P-type ATPase [General function prediction only]; Region: COG4087 469378004443 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 469378004444 metal-binding site [ion binding] 469378004445 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 469378004446 dimerization interface [polypeptide binding]; other site 469378004447 putative DNA binding site [nucleotide binding]; other site 469378004448 putative Zn2+ binding site [ion binding]; other site 469378004449 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 469378004450 domain interaction interfaces [polypeptide binding]; other site 469378004451 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 469378004452 domain interaction interfaces [polypeptide binding]; other site 469378004453 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 469378004454 domain interaction interfaces [polypeptide binding]; other site 469378004455 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 469378004456 domain interaction interfaces [polypeptide binding]; other site 469378004457 PBP superfamily domain; Region: PBP_like_2; cl17296 469378004458 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 469378004459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 469378004460 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 469378004461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469378004462 dimer interface [polypeptide binding]; other site 469378004463 conserved gate region; other site 469378004464 putative PBP binding loops; other site 469378004465 ABC-ATPase subunit interface; other site 469378004466 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 469378004467 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 469378004468 Walker A/P-loop; other site 469378004469 ATP binding site [chemical binding]; other site 469378004470 Q-loop/lid; other site 469378004471 ABC transporter signature motif; other site 469378004472 Walker B; other site 469378004473 D-loop; other site 469378004474 H-loop/switch region; other site 469378004475 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 469378004476 Sel1-like repeats; Region: SEL1; smart00671 469378004477 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 469378004478 HD domain; Region: HD_4; pfam13328 469378004479 ORF6N domain; Region: ORF6N; pfam10543 469378004480 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 469378004481 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 469378004482 Prokaryotic E2 family B; Region: Prok-E2_B; pfam14461 469378004483 ThiF family; Region: ThiF; pfam00899 469378004484 ATP binding site [chemical binding]; other site 469378004485 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 469378004486 metal binding triad [ion binding]; metal-binding site 469378004487 Uncharacterized conserved protein [Function unknown]; Region: COG1479 469378004488 Protein of unknown function DUF262; Region: DUF262; pfam03235 469378004489 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 469378004490 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 469378004491 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 469378004492 GIY-YIG motif/motif A; other site 469378004493 putative active site [active] 469378004494 putative metal binding site [ion binding]; other site 469378004495 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 469378004496 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 469378004497 active site 469378004498 metal binding site [ion binding]; metal-binding site 469378004499 homotetramer interface [polypeptide binding]; other site 469378004500 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 469378004501 Amidinotransferase; Region: Amidinotransf; cl12043 469378004502 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 469378004503 Spore germination protein; Region: Spore_permease; cl17796 469378004504 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 469378004505 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 469378004506 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 469378004507 acyl-activating enzyme (AAE) consensus motif; other site 469378004508 AMP binding site [chemical binding]; other site 469378004509 active site 469378004510 CoA binding site [chemical binding]; other site 469378004511 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 469378004512 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 469378004513 metal binding site [ion binding]; metal-binding site 469378004514 substrate binding pocket [chemical binding]; other site 469378004515 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 469378004516 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 469378004517 substrate binding site [chemical binding]; other site 469378004518 oxyanion hole (OAH) forming residues; other site 469378004519 trimer interface [polypeptide binding]; other site 469378004520 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 469378004521 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 469378004522 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 469378004523 dimer interface [polypeptide binding]; other site 469378004524 tetramer interface [polypeptide binding]; other site 469378004525 PYR/PP interface [polypeptide binding]; other site 469378004526 TPP binding site [chemical binding]; other site 469378004527 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 469378004528 TPP-binding site; other site 469378004529 salicylate biosynthesis isochorismate synthase; Validated; Region: PRK07054 469378004530 chorismate binding enzyme; Region: Chorismate_bind; cl10555 469378004531 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 469378004532 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 469378004533 motif II; other site 469378004534 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 469378004535 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 469378004536 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 469378004537 active site 469378004538 catalytic site [active] 469378004539 substrate binding site [chemical binding]; other site 469378004540 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 469378004541 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 469378004542 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 469378004543 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 469378004544 ATP-grasp domain; Region: ATP-grasp_4; cl17255 469378004545 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 469378004546 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 469378004547 FeS/SAM binding site; other site 469378004548 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 469378004549 ParB-like nuclease domain; Region: ParB; smart00470 469378004550 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 469378004551 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 469378004552 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 469378004553 Magnesium ion binding site [ion binding]; other site 469378004554 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 469378004555 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 469378004556 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 469378004557 G-X-X-G motif; other site 469378004558 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 469378004559 RxxxH motif; other site 469378004560 60Kd inner membrane protein; Region: 60KD_IMP; pfam02096 469378004561 Haemolytic domain; Region: Haemolytic; pfam01809 469378004562 Ribonuclease P; Region: Ribonuclease_P; pfam00825 469378004563 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 469378004564 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469378004565 ATP binding site [chemical binding]; other site 469378004566 Mg2+ binding site [ion binding]; other site 469378004567 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 469378004568 G-X-G motif; other site 469378004569 Transcriptional regulators [Transcription]; Region: MarR; COG1846