-- dump date 20140619_054416 -- class Genbank::misc_feature -- table misc_feature_note -- id note 292563000001 Methyltransferase domain; Region: Methyltransf_31; pfam13847 292563000002 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292563000003 S-adenosylmethionine binding site [chemical binding]; other site 292563000004 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 292563000005 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 292563000006 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546 292563000007 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 292563000008 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 292563000009 EamA-like transporter family; Region: EamA; pfam00892 292563000010 EamA-like transporter family; Region: EamA; pfam00892 292563000011 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 292563000012 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 292563000013 ring oligomerisation interface [polypeptide binding]; other site 292563000014 ATP/Mg binding site [chemical binding]; other site 292563000015 stacking interactions; other site 292563000016 hinge regions; other site 292563000017 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 292563000018 phage shock protein A; Region: phageshock_pspA; TIGR02977 292563000019 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 292563000020 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 292563000021 intersubunit interface [polypeptide binding]; other site 292563000022 active site 292563000023 zinc binding site [ion binding]; other site 292563000024 Na+ binding site [ion binding]; other site 292563000025 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 292563000026 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 292563000027 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 292563000028 Uncharacterized conserved protein [Function unknown]; Region: COG1479 292563000029 Protein of unknown function DUF262; Region: DUF262; pfam03235 292563000030 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 292563000031 alanine racemase; Reviewed; Region: alr; PRK00053 292563000032 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 292563000033 active site 292563000034 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 292563000035 dimer interface [polypeptide binding]; other site 292563000036 substrate binding site [chemical binding]; other site 292563000037 catalytic residues [active] 292563000038 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 292563000039 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 292563000040 ATP binding site [chemical binding]; other site 292563000041 putative Mg++ binding site [ion binding]; other site 292563000042 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 292563000043 nucleotide binding region [chemical binding]; other site 292563000044 ATP-binding site [chemical binding]; other site 292563000045 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 292563000046 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 292563000047 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 292563000048 catalytic loop [active] 292563000049 iron binding site [ion binding]; other site 292563000050 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 292563000051 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 292563000052 active site 292563000053 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 292563000054 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 292563000055 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 292563000056 NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504 292563000057 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 292563000058 Predicted membrane protein [Function unknown]; Region: COG2246 292563000059 GtrA-like protein; Region: GtrA; pfam04138 292563000060 Cache domain; Region: Cache_1; pfam02743 292563000061 HAMP domain; Region: HAMP; pfam00672 292563000062 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292563000063 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 292563000064 putative active site [active] 292563000065 heme pocket [chemical binding]; other site 292563000066 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292563000067 putative active site [active] 292563000068 heme pocket [chemical binding]; other site 292563000069 PAS fold; Region: PAS; pfam00989 292563000070 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292563000071 putative active site [active] 292563000072 heme pocket [chemical binding]; other site 292563000073 PAS fold; Region: PAS_4; pfam08448 292563000074 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292563000075 dimer interface [polypeptide binding]; other site 292563000076 phosphorylation site [posttranslational modification] 292563000077 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292563000078 ATP binding site [chemical binding]; other site 292563000079 Mg2+ binding site [ion binding]; other site 292563000080 G-X-G motif; other site 292563000081 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563000082 active site 292563000083 phosphorylation site [posttranslational modification] 292563000084 intermolecular recognition site; other site 292563000085 dimerization interface [polypeptide binding]; other site 292563000086 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 292563000087 23S rRNA interface [nucleotide binding]; other site 292563000088 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 292563000089 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 292563000090 peripheral dimer interface [polypeptide binding]; other site 292563000091 core dimer interface [polypeptide binding]; other site 292563000092 L10 interface [polypeptide binding]; other site 292563000093 L11 interface [polypeptide binding]; other site 292563000094 putative EF-Tu interaction site [polypeptide binding]; other site 292563000095 putative EF-G interaction site [polypeptide binding]; other site 292563000096 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 292563000097 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 292563000098 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 292563000099 active site 292563000100 catalytic tetrad [active] 292563000101 Protein of unknown function, DUF393; Region: DUF393; cl01136 292563000102 phycobillisome linker protein; Region: apcE; CHL00091 292563000103 Phycobilisome protein; Region: Phycobilisome; cl08227 292563000104 Phycobilisome protein; Region: Phycobilisome; cl08227 292563000105 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 292563000106 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 292563000107 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 292563000108 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 292563000109 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 292563000110 catalytic residues [active] 292563000111 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 292563000112 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 292563000113 active site 292563000114 (T/H)XGH motif; other site 292563000115 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 292563000116 putative active site [active] 292563000117 catalytic residue [active] 292563000118 elongation factor Ts; Reviewed; Region: tsf; PRK12332 292563000119 UBA/TS-N domain; Region: UBA; pfam00627 292563000120 Elongation factor TS; Region: EF_TS; pfam00889 292563000121 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 292563000122 rRNA interaction site [nucleotide binding]; other site 292563000123 S8 interaction site; other site 292563000124 putative laminin-1 binding site; other site 292563000125 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 292563000126 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 292563000127 ligand binding site [chemical binding]; other site 292563000128 flexible hinge region; other site 292563000129 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 292563000130 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 292563000131 Walker A motif; other site 292563000132 ATP binding site [chemical binding]; other site 292563000133 Walker B motif; other site 292563000134 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 292563000135 4Fe-4S binding domain; Region: Fer4_5; pfam12801 292563000136 4Fe-4S binding domain; Region: Fer4_5; pfam12801 292563000137 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 292563000138 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 292563000139 protein I interface; other site 292563000140 D2 interface; other site 292563000141 protein T interface; other site 292563000142 chlorophyll binding site; other site 292563000143 beta carotene binding site; other site 292563000144 pheophytin binding site; other site 292563000145 manganese-stabilizing polypeptide interface; other site 292563000146 CP43 interface; other site 292563000147 protein L interface; other site 292563000148 oxygen evolving complex binding site; other site 292563000149 bromide binding site; other site 292563000150 quinone binding site; other site 292563000151 Fe binding site [ion binding]; other site 292563000152 core light harvesting interface; other site 292563000153 cytochrome b559 alpha subunit interface; other site 292563000154 cytochrome c-550 interface; other site 292563000155 protein J interface; other site 292563000156 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 292563000157 putative active site [active] 292563000158 Dynamin family; Region: Dynamin_N; pfam00350 292563000159 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 292563000160 Lumazine binding domain; Region: Lum_binding; pfam00677 292563000161 Lumazine binding domain; Region: Lum_binding; pfam00677 292563000162 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 292563000163 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 292563000164 Probable transposase; Region: OrfB_IS605; pfam01385 292563000165 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 292563000166 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 292563000167 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 292563000168 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 292563000169 catalytic triad [active] 292563000170 cobyric acid synthase; Provisional; Region: PRK00784 292563000171 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 292563000172 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 292563000173 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 292563000174 catalytic triad [active] 292563000175 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 292563000176 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563000177 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563000178 adaptive-response sensory kinase; Validated; Region: PRK09303 292563000179 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 292563000180 tetramer interface [polypeptide binding]; other site 292563000181 dimer interface [polypeptide binding]; other site 292563000182 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292563000183 dimer interface [polypeptide binding]; other site 292563000184 phosphorylation site [posttranslational modification] 292563000185 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292563000186 ATP binding site [chemical binding]; other site 292563000187 Mg2+ binding site [ion binding]; other site 292563000188 G-X-G motif; other site 292563000189 ScpA/B protein; Region: ScpA_ScpB; pfam02616 292563000190 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 292563000191 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 292563000192 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 292563000193 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 292563000194 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 292563000195 isocitrate dehydrogenase; Validated; Region: PRK07362 292563000196 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 292563000197 NADH(P)-binding; Region: NAD_binding_10; pfam13460 292563000198 NAD(P) binding site [chemical binding]; other site 292563000199 putative active site [active] 292563000200 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 292563000201 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 292563000202 G1 box; other site 292563000203 GTP/Mg2+ binding site [chemical binding]; other site 292563000204 Switch I region; other site 292563000205 G2 box; other site 292563000206 Switch II region; other site 292563000207 G3 box; other site 292563000208 G4 box; other site 292563000209 G5 box; other site 292563000210 Domain of unknown function (DUF697); Region: DUF697; pfam05128 292563000211 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 292563000212 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 292563000213 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 292563000214 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 292563000215 diiron binding motif [ion binding]; other site 292563000216 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 292563000217 Dynamin family; Region: Dynamin_N; pfam00350 292563000218 G1 box; other site 292563000219 GTP/Mg2+ binding site [chemical binding]; other site 292563000220 G2 box; other site 292563000221 Switch I region; other site 292563000222 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 292563000223 G3 box; other site 292563000224 Switch II region; other site 292563000225 G4 box; other site 292563000226 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 292563000227 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 292563000228 inhibitor-cofactor binding pocket; inhibition site 292563000229 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292563000230 catalytic residue [active] 292563000231 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 292563000232 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 292563000233 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 292563000234 Walker A/P-loop; other site 292563000235 ATP binding site [chemical binding]; other site 292563000236 Q-loop/lid; other site 292563000237 ABC transporter signature motif; other site 292563000238 Walker B; other site 292563000239 D-loop; other site 292563000240 H-loop/switch region; other site 292563000241 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 292563000242 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 292563000243 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 292563000244 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 292563000245 Transcriptional regulator [Transcription]; Region: LytR; COG1316 292563000246 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 292563000247 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 292563000248 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292563000249 S-adenosylmethionine binding site [chemical binding]; other site 292563000250 Pirin-related protein [General function prediction only]; Region: COG1741 292563000251 Pirin; Region: Pirin; pfam02678 292563000252 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 292563000253 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 292563000254 Substrate binding site; other site 292563000255 Mg++ binding site; other site 292563000256 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 292563000257 active site 292563000258 substrate binding site [chemical binding]; other site 292563000259 CoA binding site [chemical binding]; other site 292563000260 argininosuccinate synthase; Provisional; Region: PRK13820 292563000261 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 292563000262 ANP binding site [chemical binding]; other site 292563000263 Substrate Binding Site II [chemical binding]; other site 292563000264 Substrate Binding Site I [chemical binding]; other site 292563000265 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 292563000266 core domain interface [polypeptide binding]; other site 292563000267 delta subunit interface [polypeptide binding]; other site 292563000268 epsilon subunit interface [polypeptide binding]; other site 292563000269 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 292563000270 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 292563000271 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 292563000272 beta subunit interaction interface [polypeptide binding]; other site 292563000273 Walker A motif; other site 292563000274 ATP binding site [chemical binding]; other site 292563000275 Walker B motif; other site 292563000276 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 292563000277 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 292563000278 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 292563000279 F0F1 ATP synthase subunit B; Validated; Region: PRK07352 292563000280 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 292563000281 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 292563000282 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 292563000283 ATP synthase CF0 C subunit; Region: atpH; CHL00061 292563000284 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 292563000285 ATP synthase CF0 A subunit; Region: atpI; CHL00046 292563000286 ATP synthase I chain; Region: ATP_synt_I; pfam03899 292563000287 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 292563000288 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292563000289 PAS domain; Region: PAS_9; pfam13426 292563000290 putative active site [active] 292563000291 heme pocket [chemical binding]; other site 292563000292 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 292563000293 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 292563000294 GAF domain; Region: GAF; pfam01590 292563000295 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292563000296 dimer interface [polypeptide binding]; other site 292563000297 phosphorylation site [posttranslational modification] 292563000298 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292563000299 ATP binding site [chemical binding]; other site 292563000300 Mg2+ binding site [ion binding]; other site 292563000301 G-X-G motif; other site 292563000302 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563000303 Response regulator receiver domain; Region: Response_reg; pfam00072 292563000304 active site 292563000305 phosphorylation site [posttranslational modification] 292563000306 intermolecular recognition site; other site 292563000307 dimerization interface [polypeptide binding]; other site 292563000308 Transcriptional regulator [Transcription]; Region: LysR; COG0583 292563000309 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 292563000310 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 292563000311 dimerization interface [polypeptide binding]; other site 292563000312 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 292563000313 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 292563000314 putative switch regulator; other site 292563000315 non-specific DNA interactions [nucleotide binding]; other site 292563000316 DNA binding site [nucleotide binding] 292563000317 sequence specific DNA binding site [nucleotide binding]; other site 292563000318 putative cAMP binding site [chemical binding]; other site 292563000319 MASE1; Region: MASE1; cl17823 292563000320 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292563000321 dimer interface [polypeptide binding]; other site 292563000322 phosphorylation site [posttranslational modification] 292563000323 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292563000324 ATP binding site [chemical binding]; other site 292563000325 Mg2+ binding site [ion binding]; other site 292563000326 G-X-G motif; other site 292563000327 Response regulator receiver domain; Region: Response_reg; pfam00072 292563000328 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563000329 active site 292563000330 phosphorylation site [posttranslational modification] 292563000331 intermolecular recognition site; other site 292563000332 dimerization interface [polypeptide binding]; other site 292563000333 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 292563000334 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292563000335 dimer interface [polypeptide binding]; other site 292563000336 phosphorylation site [posttranslational modification] 292563000337 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292563000338 ATP binding site [chemical binding]; other site 292563000339 Mg2+ binding site [ion binding]; other site 292563000340 G-X-G motif; other site 292563000341 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 292563000342 UreF; Region: UreF; pfam01730 292563000343 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 292563000344 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 292563000345 dimer interface [polypeptide binding]; other site 292563000346 catalytic residues [active] 292563000347 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 292563000348 alpha-gamma subunit interface [polypeptide binding]; other site 292563000349 beta-gamma subunit interface [polypeptide binding]; other site 292563000350 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 292563000351 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 292563000352 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 292563000353 active site 292563000354 photosystem I reaction center subunit PsaK; Region: PS_I_psaK; TIGR03049 292563000355 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 292563000356 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 292563000357 phosphopeptide binding site; other site 292563000358 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 292563000359 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 292563000360 RNA binding surface [nucleotide binding]; other site 292563000361 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 292563000362 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372 292563000363 Protein of unknown function (DUF790); Region: DUF790; pfam05626 292563000364 putative acyl transferase; Provisional; Region: PRK10502 292563000365 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 292563000366 putative trimer interface [polypeptide binding]; other site 292563000367 putative active site [active] 292563000368 putative substrate binding site [chemical binding]; other site 292563000369 putative CoA binding site [chemical binding]; other site 292563000370 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 292563000371 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 292563000372 ligand binding site; other site 292563000373 oligomer interface; other site 292563000374 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 292563000375 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 292563000376 dimer interface [polypeptide binding]; other site 292563000377 N-terminal domain interface [polypeptide binding]; other site 292563000378 sulfate 1 binding site; other site 292563000379 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292563000380 S-adenosylmethionine binding site [chemical binding]; other site 292563000381 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 292563000382 Predicted kinase [General function prediction only]; Region: COG0645 292563000383 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 292563000384 ATP-binding site [chemical binding]; other site 292563000385 Gluconate-6-phosphate binding site [chemical binding]; other site 292563000386 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 292563000387 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 292563000388 catalytic loop [active] 292563000389 iron binding site [ion binding]; other site 292563000390 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 292563000391 ribosomal protein L21; Region: rpl21; CHL00075 292563000392 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 292563000393 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 292563000394 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 292563000395 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 292563000396 glutamine binding [chemical binding]; other site 292563000397 catalytic triad [active] 292563000398 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 292563000399 FOG: WD40 repeat [General function prediction only]; Region: COG2319 292563000400 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 292563000401 structural tetrad; other site 292563000402 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 292563000403 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 292563000404 ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040 292563000405 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 292563000406 homodimer interface [polypeptide binding]; other site 292563000407 active site 292563000408 heterodimer interface [polypeptide binding]; other site 292563000409 catalytic residue [active] 292563000410 metal binding site [ion binding]; metal-binding site 292563000411 RbcX protein; Region: RcbX; pfam02341 292563000412 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 292563000413 multimerization interface [polypeptide binding]; other site 292563000414 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 292563000415 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 292563000416 Probable transposase; Region: OrfB_IS605; pfam01385 292563000417 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 292563000418 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 292563000419 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 292563000420 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 292563000421 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 292563000422 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 292563000423 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 292563000424 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 292563000425 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 292563000426 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 292563000427 MutS domain I; Region: MutS_I; pfam01624 292563000428 MutS domain II; Region: MutS_II; pfam05188 292563000429 MutS domain III; Region: MutS_III; pfam05192 292563000430 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 292563000431 Walker A/P-loop; other site 292563000432 ATP binding site [chemical binding]; other site 292563000433 Q-loop/lid; other site 292563000434 ABC transporter signature motif; other site 292563000435 Walker B; other site 292563000436 D-loop; other site 292563000437 H-loop/switch region; other site 292563000438 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 292563000439 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 292563000440 putative active site [active] 292563000441 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 292563000442 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 292563000443 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 292563000444 triosephosphate isomerase; Provisional; Region: PRK14565 292563000445 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 292563000446 substrate binding site [chemical binding]; other site 292563000447 dimer interface [polypeptide binding]; other site 292563000448 catalytic triad [active] 292563000449 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 292563000450 Dehydroquinase class II; Region: DHquinase_II; pfam01220 292563000451 trimer interface [polypeptide binding]; other site 292563000452 active site 292563000453 dimer interface [polypeptide binding]; other site 292563000454 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 292563000455 active site 292563000456 dinuclear metal binding site [ion binding]; other site 292563000457 dimerization interface [polypeptide binding]; other site 292563000458 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 292563000459 lipoyl attachment site [posttranslational modification]; other site 292563000460 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 292563000461 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 292563000462 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 292563000463 Mechanosensitive ion channel; Region: MS_channel; pfam00924 292563000464 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 292563000465 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 292563000466 putative active site [active] 292563000467 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 292563000468 putative active site [active] 292563000469 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 292563000470 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 292563000471 Hexamer interface [polypeptide binding]; other site 292563000472 Hexagonal pore residue; other site 292563000473 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 292563000474 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 292563000475 Hexamer interface [polypeptide binding]; other site 292563000476 Hexagonal pore residue; other site 292563000477 2TM domain; Region: 2TM; pfam13239 292563000478 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 292563000479 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 292563000480 dimer interface [polypeptide binding]; other site 292563000481 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292563000482 catalytic residue [active] 292563000483 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 292563000484 HsdM N-terminal domain; Region: HsdM_N; pfam12161 292563000485 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 292563000486 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 292563000487 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 292563000488 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 292563000489 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 292563000490 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 292563000491 ATP binding site [chemical binding]; other site 292563000492 putative Mg++ binding site [ion binding]; other site 292563000493 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 292563000494 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 292563000495 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 292563000496 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 292563000497 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 292563000498 Clp amino terminal domain; Region: Clp_N; pfam02861 292563000499 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 292563000500 Walker A motif; other site 292563000501 ATP binding site [chemical binding]; other site 292563000502 Walker B motif; other site 292563000503 arginine finger; other site 292563000504 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 292563000505 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 292563000506 Walker A motif; other site 292563000507 ATP binding site [chemical binding]; other site 292563000508 Walker B motif; other site 292563000509 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 292563000510 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 292563000511 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 292563000512 active site 292563000513 Na/Ca binding site [ion binding]; other site 292563000514 catalytic site [active] 292563000515 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 292563000516 yiaA/B two helix domain; Region: YiaAB; cl01759 292563000517 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 292563000518 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 292563000519 allophycocyanin beta subunit; Region: apcB; CHL00088 292563000520 Phycobilisome protein; Region: Phycobilisome; cl08227 292563000521 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 292563000522 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 292563000523 MgtE intracellular N domain; Region: MgtE_N; smart00924 292563000524 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 292563000525 Divalent cation transporter; Region: MgtE; pfam01769 292563000526 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 292563000527 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 292563000528 DNA binding site [nucleotide binding] 292563000529 catalytic residue [active] 292563000530 H2TH interface [polypeptide binding]; other site 292563000531 putative catalytic residues [active] 292563000532 turnover-facilitating residue; other site 292563000533 intercalation triad [nucleotide binding]; other site 292563000534 8OG recognition residue [nucleotide binding]; other site 292563000535 putative reading head residues; other site 292563000536 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 292563000537 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 292563000538 photosystem I reaction center subunit IV; Provisional; Region: PRK02749 292563000539 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 292563000540 active site 292563000541 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 292563000542 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 292563000543 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 292563000544 S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330 292563000545 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 292563000546 active site 292563000547 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 292563000548 catalytic loop [active] 292563000549 iron binding site [ion binding]; other site 292563000550 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 292563000551 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 292563000552 MerE protein; Region: MerE; cl04911 292563000553 Peptidase family M23; Region: Peptidase_M23; pfam01551 292563000554 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 292563000555 Protein phosphatase 2C; Region: PP2C; pfam00481 292563000556 active site 292563000557 DEAD-like helicases superfamily; Region: DEXDc; smart00487 292563000558 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 292563000559 ATP binding site [chemical binding]; other site 292563000560 putative Mg++ binding site [ion binding]; other site 292563000561 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 292563000562 nucleotide binding region [chemical binding]; other site 292563000563 ATP-binding site [chemical binding]; other site 292563000564 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 292563000565 active site 292563000566 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 292563000567 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 292563000568 motif II; other site 292563000569 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 292563000570 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 292563000571 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 292563000572 PsbP; Region: PsbP; pfam01789 292563000573 Maf-like protein; Region: Maf; pfam02545 292563000574 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 292563000575 active site 292563000576 dimer interface [polypeptide binding]; other site 292563000577 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 292563000578 CPxP motif; other site 292563000579 GTPase RsgA; Reviewed; Region: PRK12289 292563000580 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 292563000581 RNA binding site [nucleotide binding]; other site 292563000582 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 292563000583 GTPase/Zn-binding domain interface [polypeptide binding]; other site 292563000584 GTP/Mg2+ binding site [chemical binding]; other site 292563000585 G4 box; other site 292563000586 G5 box; other site 292563000587 G1 box; other site 292563000588 Switch I region; other site 292563000589 G2 box; other site 292563000590 G3 box; other site 292563000591 Switch II region; other site 292563000592 Uncharacterized conserved protein [Function unknown]; Region: COG5464 292563000593 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 292563000594 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 292563000595 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 292563000596 Catalytic NodB homology domain of uncharacterized chitin deacetylases and hypothetical proteins; Region: CE4_NodB_like_2; cd10958 292563000597 NodB motif; other site 292563000598 putative active site [active] 292563000599 putative catalytic site [active] 292563000600 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 292563000601 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 292563000602 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 292563000603 substrate binding site [chemical binding]; other site 292563000604 dimer interface [polypeptide binding]; other site 292563000605 ATP binding site [chemical binding]; other site 292563000606 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 292563000607 haemagglutination activity domain; Region: Haemagg_act; pfam05860 292563000608 CHAT domain; Region: CHAT; pfam12770 292563000609 PAS domain S-box; Region: sensory_box; TIGR00229 292563000610 PAS domain S-box; Region: sensory_box; TIGR00229 292563000611 Integrase core domain; Region: rve; pfam00665 292563000612 PAS domain S-box; Region: sensory_box; TIGR00229 292563000613 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292563000614 putative active site [active] 292563000615 heme pocket [chemical binding]; other site 292563000616 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 292563000617 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 292563000618 metal binding site [ion binding]; metal-binding site 292563000619 active site 292563000620 I-site; other site 292563000621 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 292563000622 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 292563000623 pyrroline-5-carboxylate reductase; Region: PLN02688 292563000624 Protein of unknown function (DUF552); Region: DUF552; cl00775 292563000625 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 292563000626 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292563000627 dimer interface [polypeptide binding]; other site 292563000628 phosphorylation site [posttranslational modification] 292563000629 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 292563000630 Coenzyme A binding pocket [chemical binding]; other site 292563000631 tryptophan-rich conserved hypothetical protein; Region: TIGR02450 292563000632 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 292563000633 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 292563000634 dimer interface [polypeptide binding]; other site 292563000635 ADP-ribose binding site [chemical binding]; other site 292563000636 active site 292563000637 nudix motif; other site 292563000638 metal binding site [ion binding]; metal-binding site 292563000639 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 292563000640 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 292563000641 motif II; other site 292563000642 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 292563000643 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 292563000644 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 292563000645 catalytic residue [active] 292563000646 30S ribosomal protein S1; Reviewed; Region: PRK07400 292563000647 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 292563000648 RNA binding site [nucleotide binding]; other site 292563000649 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 292563000650 RNA binding site [nucleotide binding]; other site 292563000651 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 292563000652 RNA binding site [nucleotide binding]; other site 292563000653 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 292563000654 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 292563000655 CO2 hydration protein (ChpXY); Region: ChpXY; cl10905 292563000656 NAD(P)H-quinone oxidoreductase subunit M; Validated; Region: PRK07363 292563000657 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 292563000658 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 292563000659 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 292563000660 Transcriptional regulator [Transcription]; Region: LysR; COG0583 292563000661 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 292563000662 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 292563000663 putative dimerization interface [polypeptide binding]; other site 292563000664 glycogen synthase; Provisional; Region: glgA; PRK00654 292563000665 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 292563000666 ADP-binding pocket [chemical binding]; other site 292563000667 homodimer interface [polypeptide binding]; other site 292563000668 Cytochrome B6-F complex subunit 5; Region: PetG; cl03637 292563000669 NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716 292563000670 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 292563000671 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 292563000672 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 292563000673 substrate binding site [chemical binding]; other site 292563000674 active site 292563000675 catalytic residues [active] 292563000676 heterodimer interface [polypeptide binding]; other site 292563000677 CpeS-like protein; Region: CpeS; pfam09367 292563000678 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 292563000679 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 292563000680 catalytic motif [active] 292563000681 Zn binding site [ion binding]; other site 292563000682 RibD C-terminal domain; Region: RibD_C; cl17279 292563000683 RNA polymerase sigma factor SigD; Validated; Region: PRK07405 292563000684 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 292563000685 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 292563000686 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 292563000687 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 292563000688 DNA binding residues [nucleotide binding] 292563000689 Transglycosylase; Region: Transgly; pfam00912 292563000690 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 292563000691 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 292563000692 NADH dehydrogenase subunit 3; Region: ndhC; CHL00022 292563000693 NADH dehydrogenase subunit K; Region: ndhK; CHL00023 292563000694 NADH dehydrogenase subunit J; Provisional; Region: PRK12494 292563000695 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 292563000696 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 292563000697 putative active site [active] 292563000698 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 292563000699 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 292563000700 inhibitor-cofactor binding pocket; inhibition site 292563000701 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292563000702 catalytic residue [active] 292563000703 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 292563000704 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 292563000705 Hexamer interface [polypeptide binding]; other site 292563000706 Hexagonal pore residue; other site 292563000707 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 292563000708 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 292563000709 Hexamer interface [polypeptide binding]; other site 292563000710 Hexagonal pore residue; other site 292563000711 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 292563000712 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 292563000713 Hexamer interface [polypeptide binding]; other site 292563000714 Hexagonal pore residue; other site 292563000715 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 292563000716 Hexamer/Pentamer interface [polypeptide binding]; other site 292563000717 central pore; other site 292563000718 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 292563000719 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 292563000720 trimer interface [polypeptide binding]; other site 292563000721 active site 292563000722 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 292563000723 putative multimerization interface [polypeptide binding]; other site 292563000724 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 292563000725 putative multimerization interface [polypeptide binding]; other site 292563000726 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 292563000727 putative multimerization interface [polypeptide binding]; other site 292563000728 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 292563000729 putative multimerization interface [polypeptide binding]; other site 292563000730 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 292563000731 putative trimer interface [polypeptide binding]; other site 292563000732 putative CoA binding site [chemical binding]; other site 292563000733 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 292563000734 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 292563000735 putative acyl-acceptor binding pocket; other site 292563000736 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 292563000737 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 292563000738 Protein of unknown function (DUF3110); Region: DUF3110; pfam11360 292563000739 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 292563000740 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 292563000741 putative active site [active] 292563000742 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 292563000743 Peptidase family M50; Region: Peptidase_M50; pfam02163 292563000744 active site 292563000745 putative substrate binding region [chemical binding]; other site 292563000746 Domain of unknown function DUF39; Region: DUF39; pfam01837 292563000747 ferrochelatase; Reviewed; Region: hemH; PRK00035 292563000748 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 292563000749 C-terminal domain interface [polypeptide binding]; other site 292563000750 active site 292563000751 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 292563000752 active site 292563000753 N-terminal domain interface [polypeptide binding]; other site 292563000754 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; pfam00504 292563000755 Predicted methyltransferases [General function prediction only]; Region: COG0313 292563000756 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 292563000757 putative SAM binding site [chemical binding]; other site 292563000758 putative homodimer interface [polypeptide binding]; other site 292563000759 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 292563000760 active site 292563000761 metal binding site [ion binding]; metal-binding site 292563000762 membrane protein; Provisional; Region: PRK14419 292563000763 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 292563000764 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 292563000765 phosphopeptide binding site; other site 292563000766 PAS domain S-box; Region: sensory_box; TIGR00229 292563000767 PAS domain S-box; Region: sensory_box; TIGR00229 292563000768 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292563000769 putative active site [active] 292563000770 heme pocket [chemical binding]; other site 292563000771 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 292563000772 metal binding site [ion binding]; metal-binding site 292563000773 active site 292563000774 I-site; other site 292563000775 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 292563000776 PAS domain S-box; Region: sensory_box; TIGR00229 292563000777 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 292563000778 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 292563000779 metal binding site [ion binding]; metal-binding site 292563000780 active site 292563000781 I-site; other site 292563000782 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 292563000783 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 292563000784 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 292563000785 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 292563000786 RimM N-terminal domain; Region: RimM; pfam01782 292563000787 PRC-barrel domain; Region: PRC; pfam05239 292563000788 FO synthase subunit 2; Reviewed; Region: PRK07360 292563000789 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 292563000790 FeS/SAM binding site; other site 292563000791 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 292563000792 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 292563000793 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 292563000794 iron-sulfur cluster [ion binding]; other site 292563000795 [2Fe-2S] cluster binding site [ion binding]; other site 292563000796 Uncharacterized conserved protein [Function unknown]; Region: COG3349 292563000797 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 292563000798 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 292563000799 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 292563000800 RIP metalloprotease RseP; Region: TIGR00054 292563000801 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 292563000802 active site 292563000803 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 292563000804 protein binding site [polypeptide binding]; other site 292563000805 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 292563000806 putative substrate binding region [chemical binding]; other site 292563000807 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 292563000808 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 292563000809 homodimer interface [polypeptide binding]; other site 292563000810 metal binding site [ion binding]; metal-binding site 292563000811 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 292563000812 homodimer interface [polypeptide binding]; other site 292563000813 active site 292563000814 putative chemical substrate binding site [chemical binding]; other site 292563000815 metal binding site [ion binding]; metal-binding site 292563000816 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 292563000817 Double zinc ribbon; Region: DZR; pfam12773 292563000818 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 292563000819 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 292563000820 phosphopeptide binding site; other site 292563000821 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 292563000822 Circadian oscillating protein COP23; Region: COP23; pfam14218 292563000823 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 292563000824 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 292563000825 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 292563000826 Probable transposase; Region: OrfB_IS605; pfam01385 292563000827 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 292563000828 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 292563000829 homotrimer interaction site [polypeptide binding]; other site 292563000830 zinc binding site [ion binding]; other site 292563000831 CDP-binding sites; other site 292563000832 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 292563000833 RuvA N terminal domain; Region: RuvA_N; pfam01330 292563000834 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 292563000835 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 292563000836 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 292563000837 active site 292563000838 metal binding site [ion binding]; metal-binding site 292563000839 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 292563000840 active site 292563000841 metal binding site [ion binding]; metal-binding site 292563000842 S-layer homology domain; Region: SLH; pfam00395 292563000843 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 292563000844 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 292563000845 Protein of unknown function DUF58; Region: DUF58; pfam01882 292563000846 Domain of unknown function (DUF427); Region: DUF427; pfam04248 292563000847 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 292563000848 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 292563000849 P-loop; other site 292563000850 Magnesium ion binding site [ion binding]; other site 292563000851 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 292563000852 Magnesium ion binding site [ion binding]; other site 292563000853 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 292563000854 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 292563000855 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 292563000856 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 292563000857 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 292563000858 MPN+ (JAMM) motif; other site 292563000859 Zinc-binding site [ion binding]; other site 292563000860 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 292563000861 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 292563000862 Probable transposase; Region: OrfB_IS605; pfam01385 292563000863 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 292563000864 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 292563000865 FAD binding domain; Region: FAD_binding_4; pfam01565 292563000866 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 292563000867 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 292563000868 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 292563000869 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 292563000870 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 292563000871 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563000872 TPR motif; other site 292563000873 TPR repeat; Region: TPR_11; pfam13414 292563000874 binding surface 292563000875 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 292563000876 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 292563000877 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 292563000878 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 292563000879 Protein of unknown function (DUF561); Region: DUF561; pfam04481 292563000880 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 292563000881 dimerization interface [polypeptide binding]; other site 292563000882 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 292563000883 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 292563000884 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 292563000885 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 292563000886 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 292563000887 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 292563000888 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 292563000889 dimer interface [polypeptide binding]; other site 292563000890 putative CheW interface [polypeptide binding]; other site 292563000891 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 292563000892 dimerization interface [polypeptide binding]; other site 292563000893 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 292563000894 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 292563000895 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 292563000896 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 292563000897 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 292563000898 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 292563000899 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 292563000900 dimer interface [polypeptide binding]; other site 292563000901 putative CheW interface [polypeptide binding]; other site 292563000902 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 292563000903 active site 292563000904 light-harvesting-like protein 3; Provisional; Region: PLN00014 292563000905 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 292563000906 acyl-activating enzyme (AAE) consensus motif; other site 292563000907 active site 292563000908 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 292563000909 CoA binding site [chemical binding]; other site 292563000910 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 292563000911 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 292563000912 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 292563000913 active site 292563000914 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 292563000915 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 292563000916 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 292563000917 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 292563000918 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 292563000919 KR domain; Region: KR; pfam08659 292563000920 putative NADP binding site [chemical binding]; other site 292563000921 active site 292563000922 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 292563000923 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 292563000924 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 292563000925 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 292563000926 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 292563000927 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 292563000928 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 292563000929 Mg++ binding site [ion binding]; other site 292563000930 putative catalytic motif [active] 292563000931 substrate binding site [chemical binding]; other site 292563000932 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 292563000933 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 292563000934 Ligand Binding Site [chemical binding]; other site 292563000935 TilS substrate binding domain; Region: TilS; pfam09179 292563000936 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 292563000937 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 292563000938 RNase E interface [polypeptide binding]; other site 292563000939 trimer interface [polypeptide binding]; other site 292563000940 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 292563000941 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 292563000942 RNase E interface [polypeptide binding]; other site 292563000943 trimer interface [polypeptide binding]; other site 292563000944 active site 292563000945 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 292563000946 putative nucleic acid binding region [nucleotide binding]; other site 292563000947 G-X-X-G motif; other site 292563000948 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 292563000949 RNA binding site [nucleotide binding]; other site 292563000950 domain interface; other site 292563000951 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 292563000952 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 292563000953 putative metal binding site [ion binding]; other site 292563000954 photosystem I assembly protein Ycf4; Provisional; Region: PRK02542 292563000955 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 292563000956 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 292563000957 trimer interface [polypeptide binding]; other site 292563000958 dimer interface [polypeptide binding]; other site 292563000959 putative active site [active] 292563000960 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 292563000961 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 292563000962 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 292563000963 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 292563000964 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 292563000965 ATP binding site [chemical binding]; other site 292563000966 putative Mg++ binding site [ion binding]; other site 292563000967 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 292563000968 nucleotide binding region [chemical binding]; other site 292563000969 ATP-binding site [chemical binding]; other site 292563000970 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 292563000971 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 292563000972 four helix bundle protein; Region: TIGR02436 292563000973 septum site-determining protein MinD; Region: minD_bact; TIGR01968 292563000974 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 292563000975 P-loop; other site 292563000976 ADP binding residues [chemical binding]; other site 292563000977 Switch I; other site 292563000978 Switch II; other site 292563000979 cell division topological specificity factor MinE; Provisional; Region: PRK13988 292563000980 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 292563000981 Mechanosensitive ion channel; Region: MS_channel; pfam00924 292563000982 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 292563000983 Mechanosensitive ion channel; Region: MS_channel; pfam00924 292563000984 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 292563000985 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 292563000986 HlyD family secretion protein; Region: HlyD_3; pfam13437 292563000987 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 292563000988 ligand binding site [chemical binding]; other site 292563000989 flexible hinge region; other site 292563000990 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 292563000991 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 292563000992 putative active site [active] 292563000993 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 292563000994 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292563000995 Walker A/P-loop; other site 292563000996 ATP binding site [chemical binding]; other site 292563000997 Q-loop/lid; other site 292563000998 ABC transporter signature motif; other site 292563000999 Walker B; other site 292563001000 D-loop; other site 292563001001 H-loop/switch region; other site 292563001002 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 292563001003 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 292563001004 ADP-ribose binding site [chemical binding]; other site 292563001005 Domain of unknown function, E. rectale Gene description (DUF3881); Region: DUF3881; pfam12997 292563001006 acetyl-CoA synthetase; Provisional; Region: PRK00174 292563001007 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 292563001008 active site 292563001009 CoA binding site [chemical binding]; other site 292563001010 acyl-activating enzyme (AAE) consensus motif; other site 292563001011 AMP binding site [chemical binding]; other site 292563001012 acetate binding site [chemical binding]; other site 292563001013 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 292563001014 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 292563001015 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 292563001016 shikimate binding site; other site 292563001017 NAD(P) binding site [chemical binding]; other site 292563001018 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 292563001019 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 292563001020 NAD(P) binding site [chemical binding]; other site 292563001021 active site 292563001022 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 292563001023 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 292563001024 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 292563001025 active site 292563001026 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 292563001027 active site 292563001028 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 292563001029 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 292563001030 active site 292563001031 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 292563001032 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 292563001033 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 292563001034 active site 292563001035 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 292563001036 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 292563001037 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 292563001038 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 292563001039 phosphoglyceromutase; Provisional; Region: PRK05434 292563001040 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 292563001041 Repair protein; Region: Repair_PSII; pfam04536 292563001042 LemA family; Region: LemA; cl00742 292563001043 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 292563001044 RNA/DNA hybrid binding site [nucleotide binding]; other site 292563001045 active site 292563001046 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 292563001047 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 292563001048 homodimer interface [polypeptide binding]; other site 292563001049 oligonucleotide binding site [chemical binding]; other site 292563001050 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186 292563001051 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 292563001052 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 292563001053 homodimer interface [polypeptide binding]; other site 292563001054 NADP binding site [chemical binding]; other site 292563001055 substrate binding site [chemical binding]; other site 292563001056 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain [DNA replication, recombination, and repair]; Region: COG1107 292563001057 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 292563001058 glucosylglycerol 3-phosphatase; Region: salt_tol_Pase; TIGR02399 292563001059 Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase); Region: Salt_tol_Pase; pfam09506 292563001060 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 292563001061 phosphopeptide binding site; other site 292563001062 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292563001063 PAS domain; Region: PAS_9; pfam13426 292563001064 putative active site [active] 292563001065 heme pocket [chemical binding]; other site 292563001066 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 292563001067 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 292563001068 metal binding site [ion binding]; metal-binding site 292563001069 active site 292563001070 I-site; other site 292563001071 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 292563001072 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 292563001073 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 292563001074 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 292563001075 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 292563001076 Synechococcus sp. strain PCC 7942 PhoA and related proteins, N-terminal metallophosphatase domain; Region: MPP_PhoA_N; cd08162 292563001077 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 292563001078 putative active site [active] 292563001079 putative metal binding site [ion binding]; other site 292563001080 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 292563001081 CHRD domain; Region: CHRD; pfam07452 292563001082 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 292563001083 pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149 292563001084 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 292563001085 tetramer interface [polypeptide binding]; other site 292563001086 TPP-binding site [chemical binding]; other site 292563001087 heterodimer interface [polypeptide binding]; other site 292563001088 phosphorylation loop region [posttranslational modification] 292563001089 Domain of unknown function (DUF389); Region: DUF389; pfam04087 292563001090 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 292563001091 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 292563001092 metal ion-dependent adhesion site (MIDAS); other site 292563001093 Response regulator receiver domain; Region: Response_reg; pfam00072 292563001094 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563001095 active site 292563001096 phosphorylation site [posttranslational modification] 292563001097 intermolecular recognition site; other site 292563001098 dimerization interface [polypeptide binding]; other site 292563001099 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 292563001100 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 292563001101 metal binding site [ion binding]; metal-binding site 292563001102 active site 292563001103 I-site; other site 292563001104 transcription antitermination protein NusB; Provisional; Region: nusB; PRK09634 292563001105 putative RNA binding site [nucleotide binding]; other site 292563001106 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 292563001107 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 292563001108 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 292563001109 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 292563001110 phycocyanin, beta subunit; Region: phycocy_beta; TIGR01339 292563001111 phycocyanin, alpha subunit; Region: phycocy_alpha; TIGR01338 292563001112 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 292563001113 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 292563001114 Zn2+ binding site [ion binding]; other site 292563001115 Mg2+ binding site [ion binding]; other site 292563001116 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 292563001117 synthetase active site [active] 292563001118 NTP binding site [chemical binding]; other site 292563001119 metal binding site [ion binding]; metal-binding site 292563001120 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 292563001121 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 292563001122 FIST N domain; Region: FIST; pfam08495 292563001123 Glutamine amidotransferase class-I; Region: GATase; pfam00117 292563001124 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 292563001125 glutamine binding [chemical binding]; other site 292563001126 catalytic triad [active] 292563001127 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 292563001128 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 292563001129 chorismate binding enzyme; Region: Chorismate_bind; cl10555 292563001130 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 292563001131 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292563001132 Mg2+ binding site [ion binding]; other site 292563001133 G-X-G motif; other site 292563001134 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 292563001135 anchoring element; other site 292563001136 dimer interface [polypeptide binding]; other site 292563001137 ATP binding site [chemical binding]; other site 292563001138 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 292563001139 active site 292563001140 metal binding site [ion binding]; metal-binding site 292563001141 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 292563001142 protein-splicing catalytic site; other site 292563001143 thioester formation/cholesterol transfer; other site 292563001144 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 292563001145 non-specific DNA binding site [nucleotide binding]; other site 292563001146 salt bridge; other site 292563001147 sequence-specific DNA binding site [nucleotide binding]; other site 292563001148 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 292563001149 active site 292563001150 metal binding site [ion binding]; metal-binding site 292563001151 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 292563001152 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 292563001153 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 292563001154 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 292563001155 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 292563001156 active site 292563001157 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 292563001158 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 292563001159 putative active site [active] 292563001160 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 292563001161 protein I interface; other site 292563001162 D2 interface; other site 292563001163 protein T interface; other site 292563001164 chlorophyll binding site; other site 292563001165 beta carotene binding site; other site 292563001166 pheophytin binding site; other site 292563001167 manganese-stabilizing polypeptide interface; other site 292563001168 CP43 interface; other site 292563001169 protein L interface; other site 292563001170 oxygen evolving complex binding site; other site 292563001171 bromide binding site; other site 292563001172 quinone binding site; other site 292563001173 Fe binding site [ion binding]; other site 292563001174 core light harvesting interface; other site 292563001175 cytochrome b559 alpha subunit interface; other site 292563001176 cytochrome c-550 interface; other site 292563001177 protein J interface; other site 292563001178 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563001179 binding surface 292563001180 TPR motif; other site 292563001181 TPR repeat; Region: TPR_11; pfam13414 292563001182 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563001183 TPR repeat; Region: TPR_11; pfam13414 292563001184 binding surface 292563001185 TPR motif; other site 292563001186 DNA primase; Validated; Region: dnaG; PRK05667 292563001187 CHC2 zinc finger; Region: zf-CHC2; pfam01807 292563001188 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 292563001189 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 292563001190 active site 292563001191 metal binding site [ion binding]; metal-binding site 292563001192 interdomain interaction site; other site 292563001193 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 292563001194 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 292563001195 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 292563001196 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 292563001197 glutaminase active site [active] 292563001198 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 292563001199 dimer interface [polypeptide binding]; other site 292563001200 active site 292563001201 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 292563001202 dimer interface [polypeptide binding]; other site 292563001203 active site 292563001204 Protein of unknown function (DUF3172); Region: DUF3172; pfam11371 292563001205 Domain of unknown function (DUF1832); Region: DUF1832; pfam08870 292563001206 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 292563001207 putative active site [active] 292563001208 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 292563001209 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 292563001210 dimer interface [polypeptide binding]; other site 292563001211 active site 292563001212 glycine-pyridoxal phosphate binding site [chemical binding]; other site 292563001213 folate binding site [chemical binding]; other site 292563001214 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292563001215 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 292563001216 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 292563001217 DNA binding residues [nucleotide binding] 292563001218 dimerization interface [polypeptide binding]; other site 292563001219 DNA polymerase III subunit beta; Validated; Region: PRK05643 292563001220 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 292563001221 putative DNA binding surface [nucleotide binding]; other site 292563001222 dimer interface [polypeptide binding]; other site 292563001223 beta-clamp/clamp loader binding surface; other site 292563001224 beta-clamp/translesion DNA polymerase binding surface; other site 292563001225 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 292563001226 GAF domain; Region: GAF_2; pfam13185 292563001227 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 292563001228 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 292563001229 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 292563001230 photosystem II protein K; Region: psbK; CHL00047 292563001231 acyl carrier protein; Provisional; Region: acpP; PRK00982 292563001232 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 292563001233 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 292563001234 dimer interface [polypeptide binding]; other site 292563001235 active site 292563001236 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 292563001237 putative catalytic site [active] 292563001238 putative phosphate binding site [ion binding]; other site 292563001239 active site 292563001240 metal binding site A [ion binding]; metal-binding site 292563001241 DNA binding site [nucleotide binding] 292563001242 putative AP binding site [nucleotide binding]; other site 292563001243 putative metal binding site B [ion binding]; other site 292563001244 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 292563001245 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 292563001246 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 292563001247 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 292563001248 G1 box; other site 292563001249 GTP/Mg2+ binding site [chemical binding]; other site 292563001250 Switch I region; other site 292563001251 G2 box; other site 292563001252 G3 box; other site 292563001253 Switch II region; other site 292563001254 G4 box; other site 292563001255 G5 box; other site 292563001256 Nucleoside recognition; Region: Gate; pfam07670 292563001257 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 292563001258 Nucleoside recognition; Region: Gate; pfam07670 292563001259 FeoA domain; Region: FeoA; pfam04023 292563001260 cyanate hydratase; Validated; Region: PRK02866 292563001261 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 292563001262 oligomer interface [polypeptide binding]; other site 292563001263 active site 292563001264 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 292563001265 SnoaL-like domain; Region: SnoaL_2; pfam12680 292563001266 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 292563001267 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 292563001268 Walker A/P-loop; other site 292563001269 ATP binding site [chemical binding]; other site 292563001270 Q-loop/lid; other site 292563001271 ABC transporter signature motif; other site 292563001272 Walker B; other site 292563001273 D-loop; other site 292563001274 H-loop/switch region; other site 292563001275 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 292563001276 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 292563001277 dimer interface [polypeptide binding]; other site 292563001278 conserved gate region; other site 292563001279 putative PBP binding loops; other site 292563001280 ABC-ATPase subunit interface; other site 292563001281 NMT1-like family; Region: NMT1_2; pfam13379 292563001282 NMT1/THI5 like; Region: NMT1; pfam09084 292563001283 histidinol-phosphate aminotransferase; Provisional; Region: PRK02610 292563001284 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 292563001285 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292563001286 homodimer interface [polypeptide binding]; other site 292563001287 catalytic residue [active] 292563001288 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 292563001289 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_7; cd04620 292563001290 FOG: CBS domain [General function prediction only]; Region: COG0517 292563001291 FOG: CBS domain [General function prediction only]; Region: COG0517 292563001292 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 292563001293 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 292563001294 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 292563001295 PAS domain S-box; Region: sensory_box; TIGR00229 292563001296 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292563001297 putative active site [active] 292563001298 heme pocket [chemical binding]; other site 292563001299 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292563001300 PAS fold; Region: PAS_3; pfam08447 292563001301 putative active site [active] 292563001302 heme pocket [chemical binding]; other site 292563001303 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292563001304 PAS domain; Region: PAS_9; pfam13426 292563001305 putative active site [active] 292563001306 heme pocket [chemical binding]; other site 292563001307 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292563001308 PAS domain; Region: PAS_9; pfam13426 292563001309 putative active site [active] 292563001310 heme pocket [chemical binding]; other site 292563001311 PAS domain S-box; Region: sensory_box; TIGR00229 292563001312 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292563001313 putative active site [active] 292563001314 heme pocket [chemical binding]; other site 292563001315 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292563001316 PAS fold; Region: PAS_3; pfam08447 292563001317 putative active site [active] 292563001318 heme pocket [chemical binding]; other site 292563001319 PAS domain S-box; Region: sensory_box; TIGR00229 292563001320 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292563001321 putative active site [active] 292563001322 heme pocket [chemical binding]; other site 292563001323 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292563001324 PAS domain; Region: PAS_9; pfam13426 292563001325 putative active site [active] 292563001326 heme pocket [chemical binding]; other site 292563001327 GAF domain; Region: GAF; pfam01590 292563001328 GAF domain; Region: GAF_2; pfam13185 292563001329 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 292563001330 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292563001331 dimer interface [polypeptide binding]; other site 292563001332 phosphorylation site [posttranslational modification] 292563001333 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292563001334 ATP binding site [chemical binding]; other site 292563001335 Mg2+ binding site [ion binding]; other site 292563001336 G-X-G motif; other site 292563001337 Response regulator receiver domain; Region: Response_reg; pfam00072 292563001338 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563001339 active site 292563001340 phosphorylation site [posttranslational modification] 292563001341 intermolecular recognition site; other site 292563001342 dimerization interface [polypeptide binding]; other site 292563001343 Response regulator receiver domain; Region: Response_reg; pfam00072 292563001344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563001345 active site 292563001346 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 292563001347 phosphorylation site [posttranslational modification] 292563001348 intermolecular recognition site; other site 292563001349 dimerization interface [polypeptide binding]; other site 292563001350 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292563001351 dimer interface [polypeptide binding]; other site 292563001352 phosphorylation site [posttranslational modification] 292563001353 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292563001354 ATP binding site [chemical binding]; other site 292563001355 Mg2+ binding site [ion binding]; other site 292563001356 G-X-G motif; other site 292563001357 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 292563001358 Catalytic domain of Protein Kinases; Region: PKc; cd00180 292563001359 active site 292563001360 ATP binding site [chemical binding]; other site 292563001361 substrate binding site [chemical binding]; other site 292563001362 activation loop (A-loop); other site 292563001363 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563001364 TPR motif; other site 292563001365 binding surface 292563001366 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563001367 binding surface 292563001368 TPR motif; other site 292563001369 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 292563001370 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563001371 binding surface 292563001372 TPR motif; other site 292563001373 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563001374 binding surface 292563001375 TPR motif; other site 292563001376 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 292563001377 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 292563001378 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 292563001379 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 292563001380 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 292563001381 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 292563001382 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 292563001383 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 292563001384 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 292563001385 active site 292563001386 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 292563001387 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 292563001388 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 292563001389 motif II; other site 292563001390 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 292563001391 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 292563001392 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 292563001393 thiamine phosphate binding site [chemical binding]; other site 292563001394 active site 292563001395 pyrophosphate binding site [ion binding]; other site 292563001396 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 292563001397 catalytic motif [active] 292563001398 Zn binding site [ion binding]; other site 292563001399 malate dehydrogenase; Reviewed; Region: PRK06223 292563001400 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 292563001401 NAD(P) binding site [chemical binding]; other site 292563001402 dimer interface [polypeptide binding]; other site 292563001403 tetramer (dimer of dimers) interface [polypeptide binding]; other site 292563001404 substrate binding site [chemical binding]; other site 292563001405 Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910 292563001406 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 292563001407 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292563001408 ATP binding site [chemical binding]; other site 292563001409 Mg2+ binding site [ion binding]; other site 292563001410 G-X-G motif; other site 292563001411 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 292563001412 ATP binding site [chemical binding]; other site 292563001413 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 292563001414 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 292563001415 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 292563001416 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 292563001417 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 292563001418 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 292563001419 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 292563001420 Subunit I/III interface [polypeptide binding]; other site 292563001421 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 292563001422 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 292563001423 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 292563001424 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292563001425 S-adenosylmethionine binding site [chemical binding]; other site 292563001426 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 292563001427 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 292563001428 Dihaem cytochrome c; Region: DHC; pfam09626 292563001429 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 292563001430 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 292563001431 phosphopeptide binding site; other site 292563001432 PAS domain S-box; Region: sensory_box; TIGR00229 292563001433 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292563001434 putative active site [active] 292563001435 heme pocket [chemical binding]; other site 292563001436 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 292563001437 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 292563001438 metal binding site [ion binding]; metal-binding site 292563001439 active site 292563001440 I-site; other site 292563001441 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 292563001442 Uncharacterized conserved protein [Function unknown]; Region: COG1565 292563001443 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 292563001444 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 292563001445 transmembrane helices; other site 292563001446 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 292563001447 TrkA-C domain; Region: TrkA_C; pfam02080 292563001448 TrkA-C domain; Region: TrkA_C; pfam02080 292563001449 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 292563001450 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 292563001451 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 292563001452 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 292563001453 RNA polymerase subunit 9; Region: RPOL9; smart00661 292563001454 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 292563001455 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 292563001456 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 292563001457 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 292563001458 fumarate hydratase; Reviewed; Region: fumC; PRK00485 292563001459 Class II fumarases; Region: Fumarase_classII; cd01362 292563001460 active site 292563001461 tetramer interface [polypeptide binding]; other site 292563001462 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 292563001463 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 292563001464 Cysteine-rich domain; Region: CCG; pfam02754 292563001465 Cysteine-rich domain; Region: CCG; pfam02754 292563001466 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 292563001467 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 292563001468 Serine hydrolase (FSH1); Region: FSH1; pfam03959 292563001469 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 292563001470 Catalytic domain of Protein Kinases; Region: PKc; cd00180 292563001471 active site 292563001472 ATP binding site [chemical binding]; other site 292563001473 substrate binding site [chemical binding]; other site 292563001474 activation loop (A-loop); other site 292563001475 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563001476 TPR repeat; Region: TPR_11; pfam13414 292563001477 binding surface 292563001478 TPR motif; other site 292563001479 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563001480 TPR repeat; Region: TPR_11; pfam13414 292563001481 TPR motif; other site 292563001482 binding surface 292563001483 TPR repeat; Region: TPR_11; pfam13414 292563001484 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563001485 binding surface 292563001486 TPR repeat; Region: TPR_11; pfam13414 292563001487 TPR motif; other site 292563001488 TPR repeat; Region: TPR_11; pfam13414 292563001489 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 292563001490 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 292563001491 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 292563001492 metal binding site [ion binding]; metal-binding site 292563001493 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 292563001494 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 292563001495 TM-ABC transporter signature motif; other site 292563001496 PetM family of cytochrome b6f complex subunit 7; Region: PetM; pfam08041 292563001497 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 292563001498 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 292563001499 putative NAD(P) binding site [chemical binding]; other site 292563001500 putative active site [active] 292563001501 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 292563001502 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 292563001503 active site 292563001504 catalytic triad [active] 292563001505 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 292563001506 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 292563001507 NADP binding site [chemical binding]; other site 292563001508 active site 292563001509 putative substrate binding site [chemical binding]; other site 292563001510 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 292563001511 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 292563001512 Surface antigen; Region: Bac_surface_Ag; pfam01103 292563001513 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 292563001514 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 292563001515 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 292563001516 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 292563001517 B12 binding site [chemical binding]; other site 292563001518 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 292563001519 FeS/SAM binding site; other site 292563001520 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 292563001521 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 292563001522 Walker A/P-loop; other site 292563001523 ATP binding site [chemical binding]; other site 292563001524 Q-loop/lid; other site 292563001525 ABC transporter signature motif; other site 292563001526 Walker B; other site 292563001527 D-loop; other site 292563001528 H-loop/switch region; other site 292563001529 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 292563001530 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08389 292563001531 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234 292563001532 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 292563001533 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 292563001534 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234 292563001535 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 292563001536 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 292563001537 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 292563001538 Walker A/P-loop; other site 292563001539 ATP binding site [chemical binding]; other site 292563001540 Q-loop/lid; other site 292563001541 ABC transporter signature motif; other site 292563001542 Walker B; other site 292563001543 D-loop; other site 292563001544 H-loop/switch region; other site 292563001545 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 292563001546 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 292563001547 Walker A/P-loop; other site 292563001548 ATP binding site [chemical binding]; other site 292563001549 Q-loop/lid; other site 292563001550 ABC transporter signature motif; other site 292563001551 Walker B; other site 292563001552 D-loop; other site 292563001553 H-loop/switch region; other site 292563001554 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 292563001555 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 292563001556 carotene isomerase; Region: carot_isom; TIGR02730 292563001557 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 292563001558 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 292563001559 catalytic loop [active] 292563001560 iron binding site [ion binding]; other site 292563001561 hypothetical protein; Validated; Region: PRK00110 292563001562 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 292563001563 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 292563001564 cofactor binding site; other site 292563001565 DNA binding site [nucleotide binding] 292563001566 substrate interaction site [chemical binding]; other site 292563001567 HpaII restriction endonuclease; Region: RE_HpaII; pfam09561 292563001568 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563001569 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 292563001570 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563001571 Tetratricopeptide repeat; Region: TPR_16; pfam13432 292563001572 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563001573 TPR motif; other site 292563001574 Protein of unknown function (DUF3146); Region: DUF3146; pfam11344 292563001575 phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816 292563001576 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 292563001577 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 292563001578 glutathione synthetase; Provisional; Region: PRK05246 292563001579 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 292563001580 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 292563001581 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 292563001582 GSH binding site [chemical binding]; other site 292563001583 catalytic residues [active] 292563001584 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 292563001585 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 292563001586 DXD motif; other site 292563001587 Cellulose synthase-like protein; Region: PLN02893 292563001588 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 292563001589 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 292563001590 substrate binding pocket [chemical binding]; other site 292563001591 membrane-bound complex binding site; other site 292563001592 hinge residues; other site 292563001593 Catalytic domain of Protein Kinases; Region: PKc; cd00180 292563001594 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 292563001595 active site 292563001596 ATP binding site [chemical binding]; other site 292563001597 substrate binding site [chemical binding]; other site 292563001598 activation loop (A-loop); other site 292563001599 Uncharacterized conserved protein [Function unknown]; Region: COG1262 292563001600 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 292563001601 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 292563001602 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 292563001603 NAD(P) binding site [chemical binding]; other site 292563001604 catalytic residues [active] 292563001605 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 292563001606 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 292563001607 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292563001608 S-adenosylmethionine binding site [chemical binding]; other site 292563001609 hypothetical protein; Validated; Region: PRK00029 292563001610 Uncharacterized conserved protein [Function unknown]; Region: COG0397 292563001611 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 292563001612 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 292563001613 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 292563001614 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 292563001615 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 292563001616 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 292563001617 putative catalytic residue [active] 292563001618 tocopherol O-methyltransferase; Region: PLN02244 292563001619 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292563001620 S-adenosylmethionine binding site [chemical binding]; other site 292563001621 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 292563001622 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 292563001623 Peptidase family M23; Region: Peptidase_M23; pfam01551 292563001624 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 292563001625 Ligand Binding Site [chemical binding]; other site 292563001626 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 292563001627 Ligand Binding Site [chemical binding]; other site 292563001628 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 292563001629 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 292563001630 5S rRNA interface [nucleotide binding]; other site 292563001631 CTC domain interface [polypeptide binding]; other site 292563001632 L16 interface [polypeptide binding]; other site 292563001633 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 292563001634 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 292563001635 GDP-binding site [chemical binding]; other site 292563001636 ACT binding site; other site 292563001637 IMP binding site; other site 292563001638 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 292563001639 dimer interface [polypeptide binding]; other site 292563001640 substrate binding site [chemical binding]; other site 292563001641 ATP binding site [chemical binding]; other site 292563001642 NifU-like domain; Region: NifU; pfam01106 292563001643 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137 292563001644 reactive center loop; other site 292563001645 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 292563001646 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 292563001647 active site 292563001648 homodimer interface [polypeptide binding]; other site 292563001649 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 292563001650 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 292563001651 ATP binding site [chemical binding]; other site 292563001652 putative Mg++ binding site [ion binding]; other site 292563001653 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 292563001654 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 292563001655 catalytic core [active] 292563001656 citrate synthase; Provisional; Region: PRK14036 292563001657 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_1; cd06112 292563001658 dimer interface [polypeptide binding]; other site 292563001659 active site 292563001660 citrylCoA binding site [chemical binding]; other site 292563001661 oxalacetate/citrate binding site [chemical binding]; other site 292563001662 coenzyme A binding site [chemical binding]; other site 292563001663 catalytic triad [active] 292563001664 extracellular substrate-binding orphan protein, GRRM family; Region: orph_peri_GRRM; TIGR04262 292563001665 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 292563001666 substrate binding pocket [chemical binding]; other site 292563001667 membrane-bound complex binding site; other site 292563001668 hinge residues; other site 292563001669 Protein of unknown function (DUF3747); Region: DUF3747; pfam12565 292563001670 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 292563001671 Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...; Region: ADA_AMPD; cd00443 292563001672 active site 292563001673 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 292563001674 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 292563001675 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 292563001676 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 292563001677 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 292563001678 ATP-grasp domain; Region: ATP-grasp_4; cl17255 292563001679 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 292563001680 IMP binding site; other site 292563001681 dimer interface [polypeptide binding]; other site 292563001682 interdomain contacts; other site 292563001683 partial ornithine binding site; other site 292563001684 YGGT family; Region: YGGT; pfam02325 292563001685 GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins; Region: GIY-YIG_AtGrxS16_like; cd10450 292563001686 GIY-YIG motif/motif A; other site 292563001687 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 292563001688 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 292563001689 Uncharacterized conserved protein [Function unknown]; Region: COG2928 292563001690 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 292563001691 ATP-grasp domain; Region: ATP-grasp; pfam02222 292563001692 PsbJ; Region: PsbJ; pfam01788 292563001693 photosystem II reaction center L; Provisional; Region: psbL; PRK00753 292563001694 cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561 292563001695 cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557 292563001696 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283 292563001697 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284 292563001698 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 292563001699 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 292563001700 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 292563001701 ATP binding site [chemical binding]; other site 292563001702 putative Mg++ binding site [ion binding]; other site 292563001703 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 292563001704 nucleotide binding region [chemical binding]; other site 292563001705 ATP-binding site [chemical binding]; other site 292563001706 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 292563001707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563001708 active site 292563001709 phosphorylation site [posttranslational modification] 292563001710 intermolecular recognition site; other site 292563001711 dimerization interface [polypeptide binding]; other site 292563001712 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 292563001713 DNA binding residues [nucleotide binding] 292563001714 dimerization interface [polypeptide binding]; other site 292563001715 ATP-grasp domain; Region: ATP-grasp_4; cl17255 292563001716 Creatinine amidohydrolase; Region: Creatininase; pfam02633 292563001717 EVE domain; Region: EVE; cl00728 292563001718 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 292563001719 RNB domain; Region: RNB; pfam00773 292563001720 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 292563001721 dsRNA binding site [nucleotide binding]; other site 292563001722 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 292563001723 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 292563001724 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 292563001725 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 292563001726 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 292563001727 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 292563001728 Catalytic site [active] 292563001729 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 292563001730 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 292563001731 metal binding site [ion binding]; metal-binding site 292563001732 DNA polymerase III subunit alpha; Reviewed; Region: PRK07373 292563001733 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 292563001734 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 292563001735 generic binding surface I; other site 292563001736 generic binding surface II; other site 292563001737 D2 subunit of photosystem II (PS II); Region: Photosystem-II_D2; cd09288 292563001738 D1 interface; other site 292563001739 chlorophyll binding site; other site 292563001740 pheophytin binding site; other site 292563001741 beta carotene binding site; other site 292563001742 cytochrome b559 beta interface; other site 292563001743 quinone binding site; other site 292563001744 cytochrome b559 alpha interface; other site 292563001745 protein J interface; other site 292563001746 protein H interface; other site 292563001747 protein X interface; other site 292563001748 core light harvesting protein interface; other site 292563001749 protein L interface; other site 292563001750 CP43 interface; other site 292563001751 protein T interface; other site 292563001752 Fe binding site [ion binding]; other site 292563001753 protein M interface; other site 292563001754 Mn-stabilizing polypeptide interface; other site 292563001755 bromide binding site; other site 292563001756 cytochrome c-550 interface; other site 292563001757 photosystem II 44 kDa protein; Region: psbC; CHL00035 292563001758 photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153 292563001759 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 292563001760 FAD binding domain; Region: FAD_binding_4; pfam01565 292563001761 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 292563001762 Fatty acid desaturase; Region: FA_desaturase; pfam00487 292563001763 Di-iron ligands [ion binding]; other site 292563001764 pyruvate kinase; Provisional; Region: PRK06354 292563001765 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 292563001766 domain interfaces; other site 292563001767 active site 292563001768 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 292563001769 tellurium resistance terB-like protein; Region: terB_like; cd07177 292563001770 metal binding site [ion binding]; metal-binding site 292563001771 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 292563001772 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 292563001773 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 292563001774 P loop; other site 292563001775 Nucleotide binding site [chemical binding]; other site 292563001776 DTAP/Switch II; other site 292563001777 Switch I; other site 292563001778 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 292563001779 putative dimer interface [polypeptide binding]; other site 292563001780 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 292563001781 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 292563001782 active site 292563001783 catalytic residues [active] 292563001784 metal binding site [ion binding]; metal-binding site 292563001785 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 292563001786 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 292563001787 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 292563001788 ligand binding site [chemical binding]; other site 292563001789 flexible hinge region; other site 292563001790 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 292563001791 putative switch regulator; other site 292563001792 non-specific DNA interactions [nucleotide binding]; other site 292563001793 DNA binding site [nucleotide binding] 292563001794 sequence specific DNA binding site [nucleotide binding]; other site 292563001795 putative cAMP binding site [chemical binding]; other site 292563001796 enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370 292563001797 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 292563001798 NAD binding site [chemical binding]; other site 292563001799 homotetramer interface [polypeptide binding]; other site 292563001800 homodimer interface [polypeptide binding]; other site 292563001801 substrate binding site [chemical binding]; other site 292563001802 active site 292563001803 chaperone protein DnaJ; Provisional; Region: PRK14299 292563001804 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 292563001805 HSP70 interaction site [polypeptide binding]; other site 292563001806 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 292563001807 substrate binding site [polypeptide binding]; other site 292563001808 dimer interface [polypeptide binding]; other site 292563001809 Response regulator receiver domain; Region: Response_reg; pfam00072 292563001810 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563001811 active site 292563001812 phosphorylation site [posttranslational modification] 292563001813 intermolecular recognition site; other site 292563001814 dimerization interface [polypeptide binding]; other site 292563001815 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 292563001816 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292563001817 phosphorylation site [posttranslational modification] 292563001818 dimer interface [polypeptide binding]; other site 292563001819 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292563001820 ATP binding site [chemical binding]; other site 292563001821 Mg2+ binding site [ion binding]; other site 292563001822 G-X-G motif; other site 292563001823 diaminopimelate decarboxylase; Region: lysA; TIGR01048 292563001824 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 292563001825 active site 292563001826 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 292563001827 substrate binding site [chemical binding]; other site 292563001828 catalytic residues [active] 292563001829 dimer interface [polypeptide binding]; other site 292563001830 Uncharacterized conserved protein [Function unknown]; Region: COG1624 292563001831 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 292563001832 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 292563001833 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 292563001834 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 292563001835 Zn2+ binding site [ion binding]; other site 292563001836 Mg2+ binding site [ion binding]; other site 292563001837 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 292563001838 putative active site [active] 292563001839 putative metal binding residues [ion binding]; other site 292563001840 signature motif; other site 292563001841 putative dimer interface [polypeptide binding]; other site 292563001842 putative phosphate binding site [ion binding]; other site 292563001843 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 292563001844 active site 292563001845 multimer interface [polypeptide binding]; other site 292563001846 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 292563001847 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 292563001848 CAP-like domain; other site 292563001849 active site 292563001850 primary dimer interface [polypeptide binding]; other site 292563001851 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 292563001852 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 292563001853 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 292563001854 MoaE homodimer interface [polypeptide binding]; other site 292563001855 MoaD interaction [polypeptide binding]; other site 292563001856 active site residues [active] 292563001857 phosphate:H+ symporter; Region: 2A0109; TIGR00887 292563001858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 292563001859 putative substrate translocation pore; other site 292563001860 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 292563001861 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 292563001862 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 292563001863 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 292563001864 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 292563001865 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 292563001866 transketolase; Region: PLN02790 292563001867 TPP-binding site [chemical binding]; other site 292563001868 dimer interface [polypeptide binding]; other site 292563001869 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 292563001870 PYR/PP interface [polypeptide binding]; other site 292563001871 dimer interface [polypeptide binding]; other site 292563001872 TPP binding site [chemical binding]; other site 292563001873 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 292563001874 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 292563001875 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 292563001876 NAD binding site [chemical binding]; other site 292563001877 homodimer interface [polypeptide binding]; other site 292563001878 active site 292563001879 substrate binding site [chemical binding]; other site 292563001880 HEAT repeats; Region: HEAT_2; pfam13646 292563001881 FOG: WD40 repeat [General function prediction only]; Region: COG2319 292563001882 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 292563001883 structural tetrad; other site 292563001884 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 292563001885 active site 292563001886 catalytic residues [active] 292563001887 DNA binding site [nucleotide binding] 292563001888 Int/Topo IB signature motif; other site 292563001889 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 292563001890 30S subunit binding site; other site 292563001891 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 292563001892 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 292563001893 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 292563001894 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 292563001895 DNA binding residues [nucleotide binding] 292563001896 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 292563001897 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 292563001898 Walker A/P-loop; other site 292563001899 ATP binding site [chemical binding]; other site 292563001900 Q-loop/lid; other site 292563001901 ABC transporter signature motif; other site 292563001902 Walker B; other site 292563001903 D-loop; other site 292563001904 H-loop/switch region; other site 292563001905 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292563001906 PAS fold; Region: PAS_3; pfam08447 292563001907 putative active site [active] 292563001908 heme pocket [chemical binding]; other site 292563001909 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292563001910 dimer interface [polypeptide binding]; other site 292563001911 phosphorylation site [posttranslational modification] 292563001912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292563001913 ATP binding site [chemical binding]; other site 292563001914 Mg2+ binding site [ion binding]; other site 292563001915 G-X-G motif; other site 292563001916 Response regulator receiver domain; Region: Response_reg; pfam00072 292563001917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563001918 active site 292563001919 phosphorylation site [posttranslational modification] 292563001920 intermolecular recognition site; other site 292563001921 dimerization interface [polypeptide binding]; other site 292563001922 Response regulator receiver domain; Region: Response_reg; pfam00072 292563001923 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563001924 active site 292563001925 phosphorylation site [posttranslational modification] 292563001926 intermolecular recognition site; other site 292563001927 dimerization interface [polypeptide binding]; other site 292563001928 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 292563001929 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 292563001930 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 292563001931 active site 292563001932 HIGH motif; other site 292563001933 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 292563001934 KMSKS motif; other site 292563001935 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 292563001936 Uncharacterized conserved protein [Function unknown]; Region: COG3937 292563001937 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 292563001938 substrate binding site [chemical binding]; other site 292563001939 putative active site [active] 292563001940 redox center [active] 292563001941 membrane complex biogenesis protein, BtpA family; Region: thylakoid_BtpA; TIGR00259 292563001942 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 292563001943 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 292563001944 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 292563001945 active site 292563001946 putative lithium-binding site [ion binding]; other site 292563001947 substrate binding site [chemical binding]; other site 292563001948 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292563001949 PAS domain; Region: PAS_9; pfam13426 292563001950 putative active site [active] 292563001951 heme pocket [chemical binding]; other site 292563001952 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292563001953 PAS fold; Region: PAS_3; pfam08447 292563001954 putative active site [active] 292563001955 heme pocket [chemical binding]; other site 292563001956 PAS domain S-box; Region: sensory_box; TIGR00229 292563001957 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292563001958 putative active site [active] 292563001959 heme pocket [chemical binding]; other site 292563001960 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 292563001961 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 292563001962 metal binding site [ion binding]; metal-binding site 292563001963 active site 292563001964 I-site; other site 292563001965 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 292563001966 Protein of function (DUF2518); Region: DUF2518; pfam10726 292563001967 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 292563001968 Phosphoglycerate kinase; Region: PGK; pfam00162 292563001969 substrate binding site [chemical binding]; other site 292563001970 hinge regions; other site 292563001971 ADP binding site [chemical binding]; other site 292563001972 catalytic site [active] 292563001973 photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044 292563001974 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 292563001975 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 292563001976 catalytic residue [active] 292563001977 putative FPP diphosphate binding site; other site 292563001978 putative FPP binding hydrophobic cleft; other site 292563001979 dimer interface [polypeptide binding]; other site 292563001980 putative IPP diphosphate binding site; other site 292563001981 ParA-like protein; Provisional; Region: PHA02518 292563001982 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 292563001983 P-loop; other site 292563001984 Magnesium ion binding site [ion binding]; other site 292563001985 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 292563001986 Catalytic domain of Protein Kinases; Region: PKc; cd00180 292563001987 active site 292563001988 ATP binding site [chemical binding]; other site 292563001989 substrate binding site [chemical binding]; other site 292563001990 activation loop (A-loop); other site 292563001991 Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184 292563001992 Protein of unknown function (DUF3493); Region: DUF3493; pfam11998 292563001993 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 292563001994 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 292563001995 active site 292563001996 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 292563001997 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 292563001998 active site 292563001999 homodimer interface [polypeptide binding]; other site 292563002000 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 292563002001 active site 292563002002 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 292563002003 elongation factor P; Validated; Region: PRK00529 292563002004 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 292563002005 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 292563002006 RNA binding site [nucleotide binding]; other site 292563002007 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 292563002008 RNA binding site [nucleotide binding]; other site 292563002009 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 292563002010 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 292563002011 carboxyltransferase (CT) interaction site; other site 292563002012 biotinylation site [posttranslational modification]; other site 292563002013 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 292563002014 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 292563002015 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 292563002016 GMP synthase; Reviewed; Region: guaA; PRK00074 292563002017 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 292563002018 AMP/PPi binding site [chemical binding]; other site 292563002019 candidate oxyanion hole; other site 292563002020 catalytic triad [active] 292563002021 potential glutamine specificity residues [chemical binding]; other site 292563002022 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 292563002023 ATP Binding subdomain [chemical binding]; other site 292563002024 Ligand Binding sites [chemical binding]; other site 292563002025 Dimerization subdomain; other site 292563002026 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 292563002027 homodimer interface [polypeptide binding]; other site 292563002028 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292563002029 catalytic residue [active] 292563002030 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 292563002031 GAF domain; Region: GAF_3; pfam13492 292563002032 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 292563002033 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 292563002034 dnd system-associated protein 4; Region: dnd_assoc_4; TIGR04062 292563002035 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 292563002036 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 292563002037 GTP binding site; other site 292563002038 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 292563002039 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 292563002040 dimer interface [polypeptide binding]; other site 292563002041 FMN binding site [chemical binding]; other site 292563002042 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 292563002043 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 292563002044 Probable transposase; Region: OrfB_IS605; pfam01385 292563002045 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 292563002046 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 292563002047 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 292563002048 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 292563002049 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 292563002050 protein binding site [polypeptide binding]; other site 292563002051 allophycocyanin, beta subunit; Region: apcB; TIGR01337 292563002052 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 292563002053 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 292563002054 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 292563002055 protein binding site [polypeptide binding]; other site 292563002056 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 292563002057 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 292563002058 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 292563002059 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 292563002060 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 292563002061 DNA binding residues [nucleotide binding] 292563002062 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 292563002063 UbiA prenyltransferase family; Region: UbiA; pfam01040 292563002064 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 292563002065 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 292563002066 metal binding site [ion binding]; metal-binding site 292563002067 dimer interface [polypeptide binding]; other site 292563002068 Response regulator receiver domain; Region: Response_reg; pfam00072 292563002069 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563002070 active site 292563002071 phosphorylation site [posttranslational modification] 292563002072 intermolecular recognition site; other site 292563002073 dimerization interface [polypeptide binding]; other site 292563002074 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292563002075 dimer interface [polypeptide binding]; other site 292563002076 phosphorylation site [posttranslational modification] 292563002077 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292563002078 ATP binding site [chemical binding]; other site 292563002079 Mg2+ binding site [ion binding]; other site 292563002080 G-X-G motif; other site 292563002081 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 292563002082 GAF domain; Region: GAF; pfam01590 292563002083 Phytochrome region; Region: PHY; pfam00360 292563002084 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292563002085 dimer interface [polypeptide binding]; other site 292563002086 phosphorylation site [posttranslational modification] 292563002087 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292563002088 ATP binding site [chemical binding]; other site 292563002089 Mg2+ binding site [ion binding]; other site 292563002090 G-X-G motif; other site 292563002091 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 292563002092 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563002093 active site 292563002094 phosphorylation site [posttranslational modification] 292563002095 intermolecular recognition site; other site 292563002096 dimerization interface [polypeptide binding]; other site 292563002097 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 292563002098 Ligand Binding Site [chemical binding]; other site 292563002099 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 292563002100 Ligand Binding Site [chemical binding]; other site 292563002101 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 292563002102 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292563002103 S-adenosylmethionine binding site [chemical binding]; other site 292563002104 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 292563002105 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 292563002106 homodimer interface [polypeptide binding]; other site 292563002107 Walker A motif; other site 292563002108 ATP binding site [chemical binding]; other site 292563002109 hydroxycobalamin binding site [chemical binding]; other site 292563002110 Walker B motif; other site 292563002111 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 292563002112 Cytochrome c; Region: Cytochrom_C; pfam00034 292563002113 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 292563002114 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 292563002115 putative active site cavity [active] 292563002116 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 292563002117 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 292563002118 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 292563002119 TrkA-N domain; Region: TrkA_N; pfam02254 292563002120 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 292563002121 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292563002122 S-adenosylmethionine binding site [chemical binding]; other site 292563002123 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 292563002124 active site 292563002125 NTP binding site [chemical binding]; other site 292563002126 metal binding triad [ion binding]; metal-binding site 292563002127 antibiotic binding site [chemical binding]; other site 292563002128 Protein of unknown function DUF86; Region: DUF86; cl01031 292563002129 carotene isomerase; Region: carot_isom; TIGR02730 292563002130 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 292563002131 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 292563002132 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 292563002133 active site 292563002134 dimer interface [polypeptide binding]; other site 292563002135 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 292563002136 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 292563002137 active site 292563002138 FMN binding site [chemical binding]; other site 292563002139 substrate binding site [chemical binding]; other site 292563002140 3Fe-4S cluster binding site [ion binding]; other site 292563002141 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 292563002142 domain interface; other site 292563002143 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 292563002144 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 292563002145 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 292563002146 Walker A/P-loop; other site 292563002147 ATP binding site [chemical binding]; other site 292563002148 Q-loop/lid; other site 292563002149 ABC transporter signature motif; other site 292563002150 Walker B; other site 292563002151 D-loop; other site 292563002152 H-loop/switch region; other site 292563002153 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 292563002154 SNF2 Helicase protein; Region: DUF3670; pfam12419 292563002155 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 292563002156 ATP binding site [chemical binding]; other site 292563002157 putative Mg++ binding site [ion binding]; other site 292563002158 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 292563002159 nucleotide binding region [chemical binding]; other site 292563002160 ATP-binding site [chemical binding]; other site 292563002161 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 292563002162 catalytic residue [active] 292563002163 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 292563002164 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 292563002165 Probable transposase; Region: OrfB_IS605; pfam01385 292563002166 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 292563002167 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 292563002168 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 292563002169 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 292563002170 homotetramer interface [polypeptide binding]; other site 292563002171 FMN binding site [chemical binding]; other site 292563002172 homodimer contacts [polypeptide binding]; other site 292563002173 putative active site [active] 292563002174 putative substrate binding site [chemical binding]; other site 292563002175 Survival protein SurE; Region: SurE; cl00448 292563002176 photochlorophyllide reductase subunit B; Region: chlB; CHL00076 292563002177 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 292563002178 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 292563002179 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 292563002180 Catalytic domain of Protein Kinases; Region: PKc; cd00180 292563002181 active site 292563002182 ATP binding site [chemical binding]; other site 292563002183 substrate binding site [chemical binding]; other site 292563002184 activation loop (A-loop); other site 292563002185 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 292563002186 Catalytic domain of Protein Kinases; Region: PKc; cd00180 292563002187 active site 292563002188 ATP binding site [chemical binding]; other site 292563002189 substrate binding site [chemical binding]; other site 292563002190 activation loop (A-loop); other site 292563002191 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 292563002192 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 292563002193 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 292563002194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 292563002195 dimer interface [polypeptide binding]; other site 292563002196 conserved gate region; other site 292563002197 putative PBP binding loops; other site 292563002198 ABC-ATPase subunit interface; other site 292563002199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 292563002200 dimer interface [polypeptide binding]; other site 292563002201 conserved gate region; other site 292563002202 putative PBP binding loops; other site 292563002203 ABC-ATPase subunit interface; other site 292563002204 Predicted membrane protein [Function unknown]; Region: COG2259 292563002205 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 292563002206 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 292563002207 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 292563002208 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 292563002209 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 292563002210 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 292563002211 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 292563002212 DNA binding site [nucleotide binding] 292563002213 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 292563002214 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 292563002215 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 292563002216 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 292563002217 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 292563002218 RPB1 interaction site [polypeptide binding]; other site 292563002219 RPB10 interaction site [polypeptide binding]; other site 292563002220 RPB11 interaction site [polypeptide binding]; other site 292563002221 RPB3 interaction site [polypeptide binding]; other site 292563002222 RPB12 interaction site [polypeptide binding]; other site 292563002223 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 292563002224 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 292563002225 active site 292563002226 ribosomal protein S20; Region: rps20; CHL00102 292563002227 hypothetical protein; Reviewed; Region: PRK00024 292563002228 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 292563002229 MPN+ (JAMM) motif; other site 292563002230 Zinc-binding site [ion binding]; other site 292563002231 Mechanosensitive ion channel; Region: MS_channel; pfam00924 292563002232 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 292563002233 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 292563002234 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 292563002235 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 292563002236 Uncharacterized conserved protein [Function unknown]; Region: COG2361 292563002237 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 292563002238 active site 292563002239 NTP binding site [chemical binding]; other site 292563002240 metal binding triad [ion binding]; metal-binding site 292563002241 antibiotic binding site [chemical binding]; other site 292563002242 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 292563002243 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 292563002244 ligand binding site [chemical binding]; other site 292563002245 homodimer interface [polypeptide binding]; other site 292563002246 NAD(P) binding site [chemical binding]; other site 292563002247 trimer interface B [polypeptide binding]; other site 292563002248 trimer interface A [polypeptide binding]; other site 292563002249 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 292563002250 Protein of unknown function (DUF433); Region: DUF433; pfam04255 292563002251 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 292563002252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 292563002253 putative PBP binding loops; other site 292563002254 dimer interface [polypeptide binding]; other site 292563002255 ABC-ATPase subunit interface; other site 292563002256 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 292563002257 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 292563002258 ABC-ATPase subunit interface; other site 292563002259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 292563002260 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 292563002261 four helix bundle protein; Region: TIGR02436 292563002262 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 292563002263 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 292563002264 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 292563002265 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 292563002266 Walker A/P-loop; other site 292563002267 ATP binding site [chemical binding]; other site 292563002268 Q-loop/lid; other site 292563002269 ABC transporter signature motif; other site 292563002270 Walker B; other site 292563002271 D-loop; other site 292563002272 H-loop/switch region; other site 292563002273 TOBE domain; Region: TOBE_2; pfam08402 292563002274 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 292563002275 HlyD family secretion protein; Region: HlyD_3; pfam13437 292563002276 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 292563002277 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 292563002278 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 292563002279 ligand binding site [chemical binding]; other site 292563002280 flexible hinge region; other site 292563002281 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 292563002282 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 292563002283 putative active site [active] 292563002284 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 292563002285 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 292563002286 Walker A/P-loop; other site 292563002287 ATP binding site [chemical binding]; other site 292563002288 Q-loop/lid; other site 292563002289 ABC transporter signature motif; other site 292563002290 Walker B; other site 292563002291 D-loop; other site 292563002292 H-loop/switch region; other site 292563002293 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 292563002294 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 292563002295 motif II; other site 292563002296 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 292563002297 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 292563002298 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 292563002299 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 292563002300 Active Sites [active] 292563002301 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 292563002302 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 292563002303 catalytic site [active] 292563002304 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 292563002305 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563002306 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 292563002307 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563002308 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563002309 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563002310 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 292563002311 V4R domain; Region: V4R; pfam02830 292563002312 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 292563002313 V4R domain; Region: V4R; pfam02830 292563002314 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 292563002315 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 292563002316 catalytic loop [active] 292563002317 iron binding site [ion binding]; other site 292563002318 Phycobilisome protein; Region: Phycobilisome; cl08227 292563002319 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563002320 TPR motif; other site 292563002321 TPR repeat; Region: TPR_11; pfam13414 292563002322 binding surface 292563002323 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 292563002324 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 292563002325 ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063 292563002326 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 292563002327 gamma subunit interface [polypeptide binding]; other site 292563002328 epsilon subunit interface [polypeptide binding]; other site 292563002329 LBP interface [polypeptide binding]; other site 292563002330 ATP synthase CF1 beta subunit; Region: atpB; CHL00060 292563002331 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 292563002332 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 292563002333 alpha subunit interaction interface [polypeptide binding]; other site 292563002334 Walker A motif; other site 292563002335 ATP binding site [chemical binding]; other site 292563002336 Walker B motif; other site 292563002337 inhibitor binding site; inhibition site 292563002338 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 292563002339 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 292563002340 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 292563002341 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 292563002342 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 292563002343 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 292563002344 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 292563002345 active site 292563002346 dimer interface [polypeptide binding]; other site 292563002347 motif 1; other site 292563002348 motif 2; other site 292563002349 motif 3; other site 292563002350 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 292563002351 anticodon binding site; other site 292563002352 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 292563002353 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 292563002354 active site 292563002355 metal binding site [ion binding]; metal-binding site 292563002356 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 292563002357 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 292563002358 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 292563002359 trmE is a tRNA modification GTPase; Region: trmE; cd04164 292563002360 G1 box; other site 292563002361 GTP/Mg2+ binding site [chemical binding]; other site 292563002362 Switch I region; other site 292563002363 G2 box; other site 292563002364 Switch II region; other site 292563002365 G3 box; other site 292563002366 G4 box; other site 292563002367 G5 box; other site 292563002368 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 292563002369 Photosystem II protein Y (PsbY); Region: PsbY; pfam06298 292563002370 succinyldiaminopimelate transaminase; Validated; Region: PRK07366 292563002371 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 292563002372 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292563002373 homodimer interface [polypeptide binding]; other site 292563002374 catalytic residue [active] 292563002375 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 292563002376 catalytic residues [active] 292563002377 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457 292563002378 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 292563002379 FeS/SAM binding site; other site 292563002380 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 292563002381 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 292563002382 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563002383 binding surface 292563002384 TPR motif; other site 292563002385 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 292563002386 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 292563002387 Thymidylate synthase complementing protein; Region: Thy1; cl03630 292563002388 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 292563002389 putative metal binding site [ion binding]; other site 292563002390 cell division protein FtsZ; Validated; Region: PRK09330 292563002391 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 292563002392 nucleotide binding site [chemical binding]; other site 292563002393 SulA interaction site; other site 292563002394 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 292563002395 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 292563002396 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 292563002397 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 292563002398 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 292563002399 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 292563002400 CAAX protease self-immunity; Region: Abi; pfam02517 292563002401 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 292563002402 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 292563002403 dimer interface [polypeptide binding]; other site 292563002404 ssDNA binding site [nucleotide binding]; other site 292563002405 tetramer (dimer of dimers) interface [polypeptide binding]; other site 292563002406 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 292563002407 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 292563002408 putative active site [active] 292563002409 metal binding site [ion binding]; metal-binding site 292563002410 homoserine dehydrogenase; Provisional; Region: PRK06349 292563002411 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 292563002412 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 292563002413 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 292563002414 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 292563002415 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 292563002416 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 292563002417 Tic22-like family; Region: Tic22; pfam04278 292563002418 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 292563002419 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 292563002420 C-terminal peptidase (prc); Region: prc; TIGR00225 292563002421 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 292563002422 protein binding site [polypeptide binding]; other site 292563002423 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 292563002424 Catalytic dyad [active] 292563002425 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 292563002426 active site 292563002427 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 292563002428 MgtE intracellular N domain; Region: MgtE_N; smart00924 292563002429 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 292563002430 Divalent cation transporter; Region: MgtE; pfam01769 292563002431 Rieske non-heme iron oxygenase (RO) family, Pheophorbide a oxygenase (PaO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of a small subfamily of enzymes found in plants as well as oxygenic...; Region: Rieske_RO_Alpha_PaO; cd03480 292563002432 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 292563002433 Pheophorbide a oxygenase; Region: PaO; pfam08417 292563002434 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 292563002435 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 292563002436 putative NAD(P) binding site [chemical binding]; other site 292563002437 active site 292563002438 putative substrate binding site [chemical binding]; other site 292563002439 Uncharacterized conserved protein containing a coiled-coil domain [Function unknown]; Region: COG5493 292563002440 Protein of unknown function (DUF3782); Region: DUF3782; pfam12644 292563002441 Protein of unknown function (DUF1626); Region: DUF1626; pfam07788 292563002442 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 292563002443 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 292563002444 metal-binding site 292563002445 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 292563002446 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 292563002447 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 292563002448 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 292563002449 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 292563002450 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 292563002451 generic binding surface II; other site 292563002452 ssDNA binding site; other site 292563002453 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 292563002454 ATP binding site [chemical binding]; other site 292563002455 putative Mg++ binding site [ion binding]; other site 292563002456 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 292563002457 nucleotide binding region [chemical binding]; other site 292563002458 ATP-binding site [chemical binding]; other site 292563002459 HEAT repeats; Region: HEAT_2; pfam13646 292563002460 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 292563002461 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 292563002462 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 292563002463 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292563002464 Walker A/P-loop; other site 292563002465 ATP binding site [chemical binding]; other site 292563002466 Q-loop/lid; other site 292563002467 ABC transporter signature motif; other site 292563002468 Walker B; other site 292563002469 D-loop; other site 292563002470 H-loop/switch region; other site 292563002471 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 292563002472 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 292563002473 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 292563002474 NAD(P) binding site [chemical binding]; other site 292563002475 active site 292563002476 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 292563002477 ribonuclease P; Reviewed; Region: rnpA; PRK03031 292563002478 Bacterial PH domain; Region: DUF304; pfam03703 292563002479 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654 292563002480 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 292563002481 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 292563002482 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 292563002483 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 292563002484 G-X-X-G motif; other site 292563002485 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 292563002486 RxxxH motif; other site 292563002487 PIN domain; Region: PIN_3; pfam13470 292563002488 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 292563002489 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 292563002490 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 292563002491 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 292563002492 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 292563002493 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292563002494 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 292563002495 putative active site [active] 292563002496 heme pocket [chemical binding]; other site 292563002497 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292563002498 putative active site [active] 292563002499 heme pocket [chemical binding]; other site 292563002500 PAS domain S-box; Region: sensory_box; TIGR00229 292563002501 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292563002502 putative active site [active] 292563002503 heme pocket [chemical binding]; other site 292563002504 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292563002505 PAS fold; Region: PAS_3; pfam08447 292563002506 putative active site [active] 292563002507 heme pocket [chemical binding]; other site 292563002508 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 292563002509 Histidine kinase; Region: HisKA_2; pfam07568 292563002510 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292563002511 ATP binding site [chemical binding]; other site 292563002512 Mg2+ binding site [ion binding]; other site 292563002513 G-X-G motif; other site 292563002514 TIGR03943 family protein; Region: TIGR03943 292563002515 Predicted permeases [General function prediction only]; Region: COG0701 292563002516 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 292563002517 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 292563002518 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 292563002519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 292563002520 putative substrate translocation pore; other site 292563002521 Major Facilitator Superfamily; Region: MFS_1; pfam07690 292563002522 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 292563002523 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 292563002524 ABC1 family; Region: ABC1; cl17513 292563002525 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 292563002526 active site 292563002527 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 292563002528 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 292563002529 active site 292563002530 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 292563002531 DHH family; Region: DHH; pfam01368 292563002532 DHHA1 domain; Region: DHHA1; pfam02272 292563002533 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 292563002534 FO synthase subunit 1; Reviewed; Region: cofG; PRK06245 292563002535 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 292563002536 FeS/SAM binding site; other site 292563002537 Bacterial SH3 domain; Region: SH3_3; pfam08239 292563002538 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 292563002539 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 292563002540 active site 292563002541 metal binding site [ion binding]; metal-binding site 292563002542 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 292563002543 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 292563002544 nucleotide binding pocket [chemical binding]; other site 292563002545 K-X-D-G motif; other site 292563002546 catalytic site [active] 292563002547 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 292563002548 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 292563002549 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 292563002550 Dimer interface [polypeptide binding]; other site 292563002551 BRCT sequence motif; other site 292563002552 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 292563002553 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 292563002554 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 292563002555 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563002556 TPR repeat; Region: TPR_11; pfam13414 292563002557 binding surface 292563002558 TPR motif; other site 292563002559 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563002560 TPR repeat; Region: TPR_11; pfam13414 292563002561 binding surface 292563002562 TPR motif; other site 292563002563 TPR repeat; Region: TPR_11; pfam13414 292563002564 Tetratricopeptide repeat; Region: TPR_16; pfam13432 292563002565 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 292563002566 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 292563002567 active site 292563002568 HIGH motif; other site 292563002569 KMSKS motif; other site 292563002570 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 292563002571 anticodon binding site; other site 292563002572 tRNA binding surface [nucleotide binding]; other site 292563002573 aspartate aminotransferase; Provisional; Region: PRK05942 292563002574 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 292563002575 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292563002576 homodimer interface [polypeptide binding]; other site 292563002577 catalytic residue [active] 292563002578 Uncharacterized conserved protein containing a coiled-coil domain [Function unknown]; Region: COG5493 292563002579 Uncharacterized conserved protein containing a coiled-coil domain [Function unknown]; Region: COG5493 292563002580 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 292563002581 FeS/SAM binding site; other site 292563002582 Radical SAM superfamily; Region: Radical_SAM; pfam04055 292563002583 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 292563002584 Protein of unknown function (DUF3531); Region: DUF3531; pfam12049 292563002585 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 292563002586 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 292563002587 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 292563002588 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 292563002589 dimerization interface [polypeptide binding]; other site 292563002590 putative ATP binding site [chemical binding]; other site 292563002591 septum formation inhibitor; Reviewed; Region: minC; PRK00513 292563002592 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 292563002593 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 292563002594 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 292563002595 active site 292563002596 metal binding site [ion binding]; metal-binding site 292563002597 hypothetical protein; Provisional; Region: PRK04323 292563002598 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 292563002599 catalytic triad [active] 292563002600 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649 292563002601 ATP-NAD kinase; Region: NAD_kinase; pfam01513 292563002602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 292563002603 Major Facilitator Superfamily; Region: MFS_1; pfam07690 292563002604 putative substrate translocation pore; other site 292563002605 Divergent PAP2 family; Region: DUF212; pfam02681 292563002606 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 292563002607 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 292563002608 substrate binding pocket [chemical binding]; other site 292563002609 chain length determination region; other site 292563002610 substrate-Mg2+ binding site; other site 292563002611 catalytic residues [active] 292563002612 aspartate-rich region 1; other site 292563002613 active site lid residues [active] 292563002614 aspartate-rich region 2; other site 292563002615 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 292563002616 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 292563002617 active site 292563002618 ATP binding site [chemical binding]; other site 292563002619 substrate binding site [chemical binding]; other site 292563002620 activation loop (A-loop); other site 292563002621 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 292563002622 dimer interface [polypeptide binding]; other site 292563002623 substrate binding site [chemical binding]; other site 292563002624 metal binding sites [ion binding]; metal-binding site 292563002625 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 292563002626 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 292563002627 Walker A/P-loop; other site 292563002628 ATP binding site [chemical binding]; other site 292563002629 Q-loop/lid; other site 292563002630 ABC transporter signature motif; other site 292563002631 Walker B; other site 292563002632 D-loop; other site 292563002633 H-loop/switch region; other site 292563002634 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 292563002635 FeS assembly protein SufD; Region: sufD; TIGR01981 292563002636 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 292563002637 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 292563002638 trimer interface [polypeptide binding]; other site 292563002639 putative metal binding site [ion binding]; other site 292563002640 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 292563002641 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 292563002642 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 292563002643 RNA polymerase sigma factor; Provisional; Region: PRK12518 292563002644 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 292563002645 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 292563002646 DNA binding residues [nucleotide binding] 292563002647 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 292563002648 dimer interface [polypeptide binding]; other site 292563002649 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 292563002650 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 292563002651 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 292563002652 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292563002653 dimer interface [polypeptide binding]; other site 292563002654 phosphorylation site [posttranslational modification] 292563002655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292563002656 ATP binding site [chemical binding]; other site 292563002657 Mg2+ binding site [ion binding]; other site 292563002658 G-X-G motif; other site 292563002659 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 292563002660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563002661 active site 292563002662 phosphorylation site [posttranslational modification] 292563002663 intermolecular recognition site; other site 292563002664 dimerization interface [polypeptide binding]; other site 292563002665 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 292563002666 GAF domain; Region: GAF; pfam01590 292563002667 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 292563002668 Protein of unknown function (DUF2930); Region: DUF2930; pfam11152 292563002669 GAF domain; Region: GAF_2; pfam13185 292563002670 Ycf27; Reviewed; Region: orf27; CHL00148 292563002671 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563002672 active site 292563002673 phosphorylation site [posttranslational modification] 292563002674 intermolecular recognition site; other site 292563002675 dimerization interface [polypeptide binding]; other site 292563002676 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 292563002677 DNA binding site [nucleotide binding] 292563002678 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 292563002679 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 292563002680 putative di-iron ligands [ion binding]; other site 292563002681 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 292563002682 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 292563002683 metal-binding site [ion binding] 292563002684 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 292563002685 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 292563002686 motif II; other site 292563002687 transaldolase/EF-hand domain-containing protein; Provisional; Region: PRK12309 292563002688 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 292563002689 active site 292563002690 dimer interface [polypeptide binding]; other site 292563002691 catalytic residue [active] 292563002692 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 292563002693 Ca2+ binding site [ion binding]; other site 292563002694 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 292563002695 putative GSH binding site [chemical binding]; other site 292563002696 catalytic residues [active] 292563002697 BolA-like protein; Region: BolA; pfam01722 292563002698 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 292563002699 Protein of unknown function (DUF3370); Region: DUF3370; pfam11850 292563002700 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 292563002701 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563002702 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563002703 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 292563002704 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 292563002705 homotetramer interface [polypeptide binding]; other site 292563002706 ligand binding site [chemical binding]; other site 292563002707 catalytic site [active] 292563002708 NAD binding site [chemical binding]; other site 292563002709 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 292563002710 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 292563002711 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 292563002712 Rubredoxin; Region: Rubredoxin; pfam00301 292563002713 iron binding site [ion binding]; other site 292563002714 Ycf48-like protein; Provisional; Region: PRK13684 292563002715 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 292563002716 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 292563002717 Psb28 protein; Region: Psb28; cl04326 292563002718 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 292563002719 MPT binding site; other site 292563002720 trimer interface [polypeptide binding]; other site 292563002721 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 292563002722 Stage II sporulation protein; Region: SpoIID; pfam08486 292563002723 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 292563002724 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 292563002725 catalytic residues [active] 292563002726 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 292563002727 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 292563002728 nucleotide binding site [chemical binding]; other site 292563002729 putative NEF/HSP70 interaction site [polypeptide binding]; other site 292563002730 SBD interface [polypeptide binding]; other site 292563002731 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 292563002732 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 292563002733 RNA/DNA hybrid binding site [nucleotide binding]; other site 292563002734 active site 292563002735 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 292563002736 lipoyl synthase; Provisional; Region: PRK05481 292563002737 Phosphate acyltransferases; Region: PlsC; smart00563 292563002738 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 292563002739 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 292563002740 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 292563002741 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 292563002742 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 292563002743 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 292563002744 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 292563002745 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 292563002746 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 292563002747 substrate binding site [chemical binding]; other site 292563002748 ATP binding site [chemical binding]; other site 292563002749 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563002750 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 292563002751 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563002752 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563002753 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 292563002754 putative hexamer interface [polypeptide binding]; other site 292563002755 putative hexagonal pore; other site 292563002756 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 292563002757 Hexamer interface [polypeptide binding]; other site 292563002758 Hexagonal pore residue; other site 292563002759 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 292563002760 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 292563002761 chaperone protein DnaJ; Provisional; Region: PRK14293 292563002762 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 292563002763 HSP70 interaction site [polypeptide binding]; other site 292563002764 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 292563002765 Zn binding sites [ion binding]; other site 292563002766 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 292563002767 dimer interface [polypeptide binding]; other site 292563002768 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 292563002769 4-alpha-glucanotransferase; Provisional; Region: PRK14508 292563002770 Photosystem II complex subunit Ycf12; Region: PSII_Ycf12; cl12139 292563002771 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 292563002772 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 292563002773 primosomal protein N' Region: priA; TIGR00595 292563002774 ATP binding site [chemical binding]; other site 292563002775 putative Mg++ binding site [ion binding]; other site 292563002776 Spt5 C-terminal nonapeptide repeat binding Spt4; Region: CTD; cl17750 292563002777 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 292563002778 ATP-binding site [chemical binding]; other site 292563002779 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 292563002780 putative active site [active] 292563002781 short chain dehydrogenase; Provisional; Region: PRK07454 292563002782 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 292563002783 NAD(P) binding site [chemical binding]; other site 292563002784 active site 292563002785 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 292563002786 dimer interface [polypeptide binding]; other site 292563002787 [2Fe-2S] cluster binding site [ion binding]; other site 292563002788 Probable transposase; Region: OrfB_IS605; pfam01385 292563002789 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 292563002790 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 292563002791 Lysyl-tRNA synthetase (class I) [Translation, ribosomal structure and biogenesis]; Region: LysS; COG1384 292563002792 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 292563002793 active site 292563002794 nucleotide binding site [chemical binding]; other site 292563002795 HIGH motif; other site 292563002796 KMSKS motif; other site 292563002797 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 292563002798 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 292563002799 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 292563002800 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 292563002801 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 292563002802 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 292563002803 HflX GTPase family; Region: HflX; cd01878 292563002804 G1 box; other site 292563002805 GTP/Mg2+ binding site [chemical binding]; other site 292563002806 Switch I region; other site 292563002807 G2 box; other site 292563002808 G3 box; other site 292563002809 Switch II region; other site 292563002810 G4 box; other site 292563002811 G5 box; other site 292563002812 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 292563002813 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 292563002814 NAD(P) binding site [chemical binding]; other site 292563002815 homotetramer interface [polypeptide binding]; other site 292563002816 homodimer interface [polypeptide binding]; other site 292563002817 active site 292563002818 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 292563002819 active site 292563002820 ribulose/triose binding site [chemical binding]; other site 292563002821 phosphate binding site [ion binding]; other site 292563002822 substrate (anthranilate) binding pocket [chemical binding]; other site 292563002823 product (indole) binding pocket [chemical binding]; other site 292563002824 hydrolase, alpha/beta fold family protein; Region: PLN02824 292563002825 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 292563002826 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 292563002827 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 292563002828 dimer interface [polypeptide binding]; other site 292563002829 motif 1; other site 292563002830 active site 292563002831 motif 2; other site 292563002832 motif 3; other site 292563002833 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 292563002834 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 292563002835 phosphopeptide binding site; other site 292563002836 Transglycosylase; Region: Transgly; pfam00912 292563002837 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 292563002838 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 292563002839 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 292563002840 active site 292563002841 cell division protein; Validated; Region: ftsH; CHL00176 292563002842 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 292563002843 Walker A motif; other site 292563002844 ATP binding site [chemical binding]; other site 292563002845 Walker B motif; other site 292563002846 arginine finger; other site 292563002847 Peptidase family M41; Region: Peptidase_M41; pfam01434 292563002848 Curli production assembly/transport component CsgG; Region: CsgG; pfam03783 292563002849 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292563002850 S-adenosylmethionine binding site [chemical binding]; other site 292563002851 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 292563002852 nucleotide binding site/active site [active] 292563002853 HIT family signature motif; other site 292563002854 catalytic residue [active] 292563002855 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 292563002856 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 292563002857 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 292563002858 inhibitor-cofactor binding pocket; inhibition site 292563002859 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292563002860 catalytic residue [active] 292563002861 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 292563002862 Phycobilisome protein; Region: Phycobilisome; cl08227 292563002863 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812 292563002864 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 292563002865 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 292563002866 active site 292563002867 AAA domain; Region: AAA_26; pfam13500 292563002868 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 292563002869 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 292563002870 Taspase1_like domains; Taspase1 catalyzes the cleavage of the mix lineage leukemia (MLL) nuclear protein and transcription factor TFIIA. Taspase1 is a threonine aspartase, a member of the Ntn hydrolase superfamily and the type 2 asparaginase family. A...; Region: Taspase1_like; cd04514 292563002871 active site 292563002872 dimer interface [polypeptide binding]; other site 292563002873 catalytic nucleophile [active] 292563002874 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 292563002875 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 292563002876 dimer interface [polypeptide binding]; other site 292563002877 putative functional site; other site 292563002878 putative MPT binding site; other site 292563002879 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 292563002880 Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158 292563002881 putative homodimer interface [polypeptide binding]; other site 292563002882 putative homotetramer interface [polypeptide binding]; other site 292563002883 putative metal binding site [ion binding]; other site 292563002884 putative homodimer-homodimer interface [polypeptide binding]; other site 292563002885 putative allosteric switch controlling residues; other site 292563002886 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 292563002887 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 292563002888 Domain of unknown function (DUF3598); Region: DUF3598; pfam12204 292563002889 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 292563002890 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 292563002891 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 292563002892 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 292563002893 16S/18S rRNA binding site [nucleotide binding]; other site 292563002894 S13e-L30e interaction site [polypeptide binding]; other site 292563002895 25S rRNA binding site [nucleotide binding]; other site 292563002896 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 292563002897 3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396 292563002898 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 292563002899 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 292563002900 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 292563002901 Helix-turn-helix domain; Region: HTH_25; pfam13413 292563002902 non-specific DNA binding site [nucleotide binding]; other site 292563002903 salt bridge; other site 292563002904 sequence-specific DNA binding site [nucleotide binding]; other site 292563002905 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 292563002906 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 292563002907 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 292563002908 RNA binding surface [nucleotide binding]; other site 292563002909 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 292563002910 active site 292563002911 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 292563002912 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 292563002913 Domain of unknown function (DUF814); Region: DUF814; pfam05670 292563002914 hypothetical protein; Validated; Region: PRK01415 292563002915 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 292563002916 active site residue [active] 292563002917 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 292563002918 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 292563002919 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 292563002920 active site 292563002921 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 292563002922 dimerization interface [polypeptide binding]; other site 292563002923 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 292563002924 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292563002925 putative active site [active] 292563002926 heme pocket [chemical binding]; other site 292563002927 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292563002928 dimer interface [polypeptide binding]; other site 292563002929 phosphorylation site [posttranslational modification] 292563002930 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292563002931 ATP binding site [chemical binding]; other site 292563002932 Mg2+ binding site [ion binding]; other site 292563002933 G-X-G motif; other site 292563002934 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 292563002935 PRC-barrel domain; Region: PRC; pfam05239 292563002936 Predicted membrane protein [Function unknown]; Region: COG2119 292563002937 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 292563002938 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 292563002939 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 292563002940 NAD binding site [chemical binding]; other site 292563002941 putative substrate binding site 2 [chemical binding]; other site 292563002942 putative substrate binding site 1 [chemical binding]; other site 292563002943 active site 292563002944 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 292563002945 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 292563002946 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 292563002947 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 292563002948 S-adenosylmethionine synthetase; Validated; Region: PRK05250 292563002949 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 292563002950 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 292563002951 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 292563002952 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 292563002953 HicB family; Region: HicB; pfam05534 292563002954 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 292563002955 citrylCoA binding site [chemical binding]; other site 292563002956 ferredoxin-sulfite reductase; Region: sir; TIGR02042 292563002957 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 292563002958 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 292563002959 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 292563002960 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 292563002961 [4Fe-4S] binding site [ion binding]; other site 292563002962 molybdopterin cofactor binding site; other site 292563002963 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 292563002964 molybdopterin cofactor binding site; other site 292563002965 FtsH Extracellular; Region: FtsH_ext; pfam06480 292563002966 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 292563002967 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 292563002968 Walker A motif; other site 292563002969 ATP binding site [chemical binding]; other site 292563002970 Walker B motif; other site 292563002971 arginine finger; other site 292563002972 Peptidase family M41; Region: Peptidase_M41; pfam01434 292563002973 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 292563002974 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 292563002975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563002976 active site 292563002977 phosphorylation site [posttranslational modification] 292563002978 intermolecular recognition site; other site 292563002979 dimerization interface [polypeptide binding]; other site 292563002980 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 292563002981 DNA binding site [nucleotide binding] 292563002982 Transposase IS200 like; Region: Y1_Tnp; pfam01797 292563002983 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 292563002984 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 292563002985 Probable transposase; Region: OrfB_IS605; pfam01385 292563002986 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 292563002987 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 292563002988 G1 box; other site 292563002989 putative GEF interaction site [polypeptide binding]; other site 292563002990 GTP/Mg2+ binding site [chemical binding]; other site 292563002991 Switch I region; other site 292563002992 G2 box; other site 292563002993 G3 box; other site 292563002994 Switch II region; other site 292563002995 G4 box; other site 292563002996 G5 box; other site 292563002997 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 292563002998 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 292563002999 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 292563003000 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 292563003001 putative catalytic cysteine [active] 292563003002 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 292563003003 putative active site [active] 292563003004 metal binding site [ion binding]; metal-binding site 292563003005 calcium/proton exchanger (cax); Region: cax; TIGR00378 292563003006 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 292563003007 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 292563003008 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 292563003009 magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031 292563003010 Walker A motif; other site 292563003011 ATP binding site [chemical binding]; other site 292563003012 Walker B motif; other site 292563003013 arginine finger; other site 292563003014 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 292563003015 metal ion-dependent adhesion site (MIDAS); other site 292563003016 Protein of unknown function DUF262; Region: DUF262; pfam03235 292563003017 photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875 292563003018 photosystem II 47 kDa protein; Region: psbB; CHL00062 292563003019 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 292563003020 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 292563003021 TPR repeat; Region: TPR_11; pfam13414 292563003022 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563003023 binding surface 292563003024 TPR motif; other site 292563003025 TPR repeat; Region: TPR_11; pfam13414 292563003026 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 292563003027 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563003028 binding surface 292563003029 TPR motif; other site 292563003030 TPR repeat; Region: TPR_11; pfam13414 292563003031 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563003032 binding surface 292563003033 TPR motif; other site 292563003034 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 292563003035 NurA nuclease; Region: NurA; smart00933 292563003036 magnesium chelatase subunit H; Provisional; Region: PRK12493 292563003037 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 292563003038 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 292563003039 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 292563003040 Protein of unknown function DUF262; Region: DUF262; pfam03235 292563003041 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 292563003042 Domain of unknown function DUF29; Region: DUF29; pfam01724 292563003043 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 292563003044 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 292563003045 active site 292563003046 dimer interface [polypeptide binding]; other site 292563003047 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 292563003048 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 292563003049 active site 292563003050 FMN binding site [chemical binding]; other site 292563003051 substrate binding site [chemical binding]; other site 292563003052 3Fe-4S cluster binding site [ion binding]; other site 292563003053 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 292563003054 domain interface; other site 292563003055 hypothetical protein; Reviewed; Region: PRK12497 292563003056 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 292563003057 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 292563003058 dimerization interface [polypeptide binding]; other site 292563003059 domain crossover interface; other site 292563003060 redox-dependent activation switch; other site 292563003061 Predicted transcriptional regulators [Transcription]; Region: COG1695 292563003062 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 292563003063 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 292563003064 HlyD family secretion protein; Region: HlyD_3; pfam13437 292563003065 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 292563003066 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 292563003067 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 292563003068 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 292563003069 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 292563003070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 292563003071 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 292563003072 active site 292563003073 catalytic residues [active] 292563003074 metal binding site [ion binding]; metal-binding site 292563003075 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 292563003076 Protein of unknown function (DUF760); Region: DUF760; pfam05542 292563003077 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 292563003078 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 292563003079 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 292563003080 Predicted transcriptional regulator [Transcription]; Region: COG1959 292563003081 Transcriptional regulator; Region: Rrf2; cl17282 292563003082 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 292563003083 DNA protecting protein DprA; Region: dprA; TIGR00732 292563003084 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 292563003085 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 292563003086 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 292563003087 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 292563003088 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 292563003089 Walker A/P-loop; other site 292563003090 ATP binding site [chemical binding]; other site 292563003091 Q-loop/lid; other site 292563003092 ABC transporter signature motif; other site 292563003093 Walker B; other site 292563003094 D-loop; other site 292563003095 H-loop/switch region; other site 292563003096 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 292563003097 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 292563003098 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 292563003099 ABC-ATPase subunit interface; other site 292563003100 dimer interface [polypeptide binding]; other site 292563003101 putative PBP binding regions; other site 292563003102 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 292563003103 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 292563003104 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 292563003105 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 292563003106 intersubunit interface [polypeptide binding]; other site 292563003107 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 292563003108 Predicted membrane protein [Function unknown]; Region: COG2324 292563003109 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 292563003110 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 292563003111 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 292563003112 recombination protein RecR; Reviewed; Region: recR; PRK00076 292563003113 Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278 292563003114 RecR protein; Region: RecR; pfam02132 292563003115 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 292563003116 putative active site [active] 292563003117 putative metal-binding site [ion binding]; other site 292563003118 tetramer interface [polypeptide binding]; other site 292563003119 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 292563003120 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 292563003121 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 292563003122 putative active site [active] 292563003123 catalytic triad [active] 292563003124 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 292563003125 ligand binding site [chemical binding]; other site 292563003126 active site 292563003127 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 292563003128 Stage II sporulation protein; Region: SpoIID; pfam08486 292563003129 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 292563003130 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 292563003131 Mechanosensitive ion channel; Region: MS_channel; pfam00924 292563003132 Domain of unknown function (DUF202); Region: DUF202; cl09954 292563003133 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 292563003134 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 292563003135 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 292563003136 active site 292563003137 catalytic residues [active] 292563003138 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 292563003139 putative bicarbonate transporter, IctB family; Region: 2A73; TIGR00947 292563003140 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 292563003141 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 292563003142 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 292563003143 dimer interface [polypeptide binding]; other site 292563003144 active site 292563003145 heme binding site [chemical binding]; other site 292563003146 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 292563003147 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 292563003148 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 292563003149 motif II; other site 292563003150 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 292563003151 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 292563003152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 292563003153 putative substrate translocation pore; other site 292563003154 Major Facilitator Superfamily; Region: MFS_1; pfam07690 292563003155 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 292563003156 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 292563003157 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 292563003158 FeS/SAM binding site; other site 292563003159 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 292563003160 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 292563003161 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 292563003162 catalytic site [active] 292563003163 G-X2-G-X-G-K; other site 292563003164 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 292563003165 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 292563003166 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 292563003167 active site 292563003168 Riboflavin kinase; Region: Flavokinase; pfam01687 292563003169 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 292563003170 ribosomal protein S4; Reviewed; Region: rps4; CHL00113 292563003171 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 292563003172 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 292563003173 RNA binding surface [nucleotide binding]; other site 292563003174 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 292563003175 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 292563003176 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 292563003177 Qi binding site; other site 292563003178 intrachain domain interface; other site 292563003179 interchain domain interface [polypeptide binding]; other site 292563003180 heme bH binding site [chemical binding]; other site 292563003181 heme bL binding site [chemical binding]; other site 292563003182 Qo binding site; other site 292563003183 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 292563003184 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 292563003185 interchain domain interface [polypeptide binding]; other site 292563003186 intrachain domain interface; other site 292563003187 Qi binding site; other site 292563003188 Qo binding site; other site 292563003189 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 292563003190 Predicted transporter component [General function prediction only]; Region: COG2391 292563003191 Sulphur transport; Region: Sulf_transp; pfam04143 292563003192 Predicted transporter component [General function prediction only]; Region: COG2391 292563003193 Sulphur transport; Region: Sulf_transp; pfam04143 292563003194 Domain of unknown function DUF29; Region: DUF29; pfam01724 292563003195 Domain of unknown function DUF29; Region: DUF29; pfam01724 292563003196 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 292563003197 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 292563003198 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 292563003199 P loop; other site 292563003200 Nucleotide binding site [chemical binding]; other site 292563003201 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 292563003202 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12567 292563003203 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 292563003204 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 292563003205 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 292563003206 dimerization interface [polypeptide binding]; other site 292563003207 putative DNA binding site [nucleotide binding]; other site 292563003208 putative Zn2+ binding site [ion binding]; other site 292563003209 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 292563003210 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 292563003211 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 292563003212 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292563003213 dimer interface [polypeptide binding]; other site 292563003214 phosphorylation site [posttranslational modification] 292563003215 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292563003216 ATP binding site [chemical binding]; other site 292563003217 Mg2+ binding site [ion binding]; other site 292563003218 G-X-G motif; other site 292563003219 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 292563003220 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563003221 active site 292563003222 phosphorylation site [posttranslational modification] 292563003223 intermolecular recognition site; other site 292563003224 dimerization interface [polypeptide binding]; other site 292563003225 glycogen branching enzyme; Provisional; Region: PRK05402 292563003226 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 292563003227 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 292563003228 active site 292563003229 catalytic site [active] 292563003230 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 292563003231 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 292563003232 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 292563003233 YcfA-like protein; Region: YcfA; pfam07927 292563003234 XisI protein; Region: XisI; pfam08869 292563003235 XisH protein; Region: XisH; pfam08814 292563003236 XisI protein; Region: XisI; pfam08869 292563003237 XisH protein; Region: XisH; pfam08814 292563003238 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 292563003239 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 292563003240 substrate binding site [chemical binding]; other site 292563003241 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 292563003242 substrate binding site [chemical binding]; other site 292563003243 ligand binding site [chemical binding]; other site 292563003244 WxcM-like, C-terminal; Region: FdtA; pfam05523 292563003245 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 292563003246 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 292563003247 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 292563003248 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 292563003249 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 292563003250 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 292563003251 dihydropteroate synthase; Region: DHPS; TIGR01496 292563003252 substrate binding pocket [chemical binding]; other site 292563003253 dimer interface [polypeptide binding]; other site 292563003254 inhibitor binding site; inhibition site 292563003255 Coatomer WD associated region; Region: Coatomer_WDAD; pfam04053 292563003256 L-aspartate oxidase; Provisional; Region: PRK07395 292563003257 L-aspartate oxidase; Provisional; Region: PRK06175 292563003258 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 292563003259 Uncharacterized conserved protein [Function unknown]; Region: COG3937 292563003260 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 292563003261 Catalytic domain of Protein Kinases; Region: PKc; cd00180 292563003262 active site 292563003263 ATP binding site [chemical binding]; other site 292563003264 substrate binding site [chemical binding]; other site 292563003265 activation loop (A-loop); other site 292563003266 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 292563003267 active site 292563003268 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 292563003269 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 292563003270 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 292563003271 NAD(P) binding site [chemical binding]; other site 292563003272 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 292563003273 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 292563003274 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 292563003275 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 292563003276 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 292563003277 Peptidase family M50; Region: Peptidase_M50; pfam02163 292563003278 active site 292563003279 putative substrate binding region [chemical binding]; other site 292563003280 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 292563003281 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 292563003282 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292563003283 Walker A/P-loop; other site 292563003284 ATP binding site [chemical binding]; other site 292563003285 Q-loop/lid; other site 292563003286 ABC transporter signature motif; other site 292563003287 Walker B; other site 292563003288 D-loop; other site 292563003289 H-loop/switch region; other site 292563003290 Part of AAA domain; Region: AAA_19; pfam13245 292563003291 AAA domain; Region: AAA_11; pfam13086 292563003292 AAA domain; Region: AAA_12; pfam13087 292563003293 Protein kinase domain; Region: Pkinase; pfam00069 292563003294 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 292563003295 active site 292563003296 ATP binding site [chemical binding]; other site 292563003297 substrate binding site [chemical binding]; other site 292563003298 activation loop (A-loop); other site 292563003299 Protein phosphatase 2C; Region: PP2C_2; pfam13672 292563003300 active site 292563003301 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 292563003302 metal ion-dependent adhesion site (MIDAS); other site 292563003303 ammonium transporter; Region: amt; TIGR00836 292563003304 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 292563003305 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292563003306 dimer interface [polypeptide binding]; other site 292563003307 phosphorylation site [posttranslational modification] 292563003308 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292563003309 ATP binding site [chemical binding]; other site 292563003310 Mg2+ binding site [ion binding]; other site 292563003311 G-X-G motif; other site 292563003312 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 292563003313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563003314 active site 292563003315 phosphorylation site [posttranslational modification] 292563003316 intermolecular recognition site; other site 292563003317 dimerization interface [polypeptide binding]; other site 292563003318 Response regulator receiver domain; Region: Response_reg; pfam00072 292563003319 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563003320 active site 292563003321 phosphorylation site [posttranslational modification] 292563003322 intermolecular recognition site; other site 292563003323 dimerization interface [polypeptide binding]; other site 292563003324 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 292563003325 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 292563003326 metal binding site [ion binding]; metal-binding site 292563003327 active site 292563003328 I-site; other site 292563003329 photochlorophyllide reductase subunit L; Region: chlL; CHL00072 292563003330 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 292563003331 P-loop; other site 292563003332 Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979 292563003333 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 292563003334 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 292563003335 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 292563003336 intersubunit interface [polypeptide binding]; other site 292563003337 active site 292563003338 Zn2+ binding site [ion binding]; other site 292563003339 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 292563003340 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 292563003341 Cupin domain; Region: Cupin_2; pfam07883 292563003342 Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229 292563003343 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 292563003344 motif II; other site 292563003345 Predicted GTPase [General function prediction only]; Region: COG3596 292563003346 YfjP GTPase; Region: YfjP; cd11383 292563003347 G1 box; other site 292563003348 GTP/Mg2+ binding site [chemical binding]; other site 292563003349 Switch I region; other site 292563003350 G2 box; other site 292563003351 Switch II region; other site 292563003352 G3 box; other site 292563003353 G4 box; other site 292563003354 glycerol kinase; Provisional; Region: glpK; PRK00047 292563003355 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 292563003356 N- and C-terminal domain interface [polypeptide binding]; other site 292563003357 active site 292563003358 MgATP binding site [chemical binding]; other site 292563003359 catalytic site [active] 292563003360 metal binding site [ion binding]; metal-binding site 292563003361 glycerol binding site [chemical binding]; other site 292563003362 homotetramer interface [polypeptide binding]; other site 292563003363 homodimer interface [polypeptide binding]; other site 292563003364 FBP binding site [chemical binding]; other site 292563003365 protein IIAGlc interface [polypeptide binding]; other site 292563003366 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 292563003367 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 292563003368 domain interfaces; other site 292563003369 active site 292563003370 hypothetical protein; Provisional; Region: PRK11770 292563003371 Domain of unknown function (DUF307); Region: DUF307; pfam03733 292563003372 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 292563003373 AMP binding site [chemical binding]; other site 292563003374 metal binding site [ion binding]; metal-binding site 292563003375 active site 292563003376 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 292563003377 active site 292563003378 dimer interfaces [polypeptide binding]; other site 292563003379 catalytic residues [active] 292563003380 putative lipid kinase; Reviewed; Region: PRK00861 292563003381 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 292563003382 PEGA domain; Region: PEGA; pfam08308 292563003383 cobalamin synthase; Reviewed; Region: cobS; PRK00235 292563003384 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 292563003385 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 292563003386 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 292563003387 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 292563003388 active site residue [active] 292563003389 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 292563003390 active site residue [active] 292563003391 Uncharacterized conserved protein [Function unknown]; Region: COG1432 292563003392 LabA_like proteins; Region: LabA; cd10911 292563003393 putative metal binding site [ion binding]; other site 292563003394 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 292563003395 Ycf46; Provisional; Region: ycf46; CHL00195 292563003396 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 292563003397 Walker A motif; other site 292563003398 ATP binding site [chemical binding]; other site 292563003399 Walker B motif; other site 292563003400 arginine finger; other site 292563003401 Protein of unknown function (DUF1257); Region: DUF1257; pfam06868 292563003402 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 292563003403 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 292563003404 Walker A/P-loop; other site 292563003405 ATP binding site [chemical binding]; other site 292563003406 Q-loop/lid; other site 292563003407 ABC transporter signature motif; other site 292563003408 Walker B; other site 292563003409 D-loop; other site 292563003410 H-loop/switch region; other site 292563003411 putative addiction module antidote; Region: doc_partner; TIGR02609 292563003412 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 292563003413 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 292563003414 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 292563003415 Coenzyme A binding pocket [chemical binding]; other site 292563003416 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 292563003417 ribosomal protein L33; Region: rpl33; CHL00104 292563003418 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 292563003419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 292563003420 dimer interface [polypeptide binding]; other site 292563003421 conserved gate region; other site 292563003422 ABC-ATPase subunit interface; other site 292563003423 Domain of unknown function (DUF309); Region: DUF309; pfam03745 292563003424 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 292563003425 Tetratricopeptide repeat; Region: TPR_16; pfam13432 292563003426 RNA methyltransferase, RsmE family; Region: TIGR00046 292563003427 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 292563003428 Uncharacterized conserved protein [Function unknown]; Region: COG0062 292563003429 putative carbohydrate kinase; Provisional; Region: PRK10565 292563003430 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 292563003431 putative substrate binding site [chemical binding]; other site 292563003432 putative ATP binding site [chemical binding]; other site 292563003433 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 292563003434 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 292563003435 active site 292563003436 octamer interface [polypeptide binding]; other site 292563003437 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 292563003438 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 292563003439 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 292563003440 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 292563003441 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 292563003442 catalytic residues [active] 292563003443 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 292563003444 Na binding site [ion binding]; other site 292563003445 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 292563003446 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 292563003447 beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275 292563003448 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 292563003449 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563003450 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 292563003451 tartrate dehydrogenase; Region: TTC; TIGR02089 292563003452 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 292563003453 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 292563003454 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 292563003455 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292563003456 S-adenosylmethionine binding site [chemical binding]; other site 292563003457 Predicted membrane protein [Function unknown]; Region: COG1971 292563003458 Domain of unknown function DUF; Region: DUF204; pfam02659 292563003459 Domain of unknown function DUF; Region: DUF204; pfam02659 292563003460 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 292563003461 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 292563003462 FtsX-like permease family; Region: FtsX; pfam02687 292563003463 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 292563003464 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 292563003465 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 292563003466 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 292563003467 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 292563003468 [2Fe-2S] cluster binding site [ion binding]; other site 292563003469 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 292563003470 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 292563003471 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 292563003472 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 292563003473 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 292563003474 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 292563003475 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440 292563003476 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 292563003477 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 292563003478 AAA domain; Region: AAA_33; pfam13671 292563003479 AAA domain; Region: AAA_17; pfam13207 292563003480 WYL domain; Region: WYL; pfam13280 292563003481 pantothenate kinase; Reviewed; Region: PRK13331 292563003482 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12870 292563003483 UbiA prenyltransferase family; Region: UbiA; pfam01040 292563003484 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 292563003485 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 292563003486 dimer interface [polypeptide binding]; other site 292563003487 anticodon binding site; other site 292563003488 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 292563003489 homodimer interface [polypeptide binding]; other site 292563003490 motif 1; other site 292563003491 active site 292563003492 motif 2; other site 292563003493 GAD domain; Region: GAD; pfam02938 292563003494 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 292563003495 active site 292563003496 motif 3; other site 292563003497 Domain of unknown function (DUF1823); Region: DUF1823; pfam08853 292563003498 MgtC family; Region: MgtC; pfam02308 292563003499 CAAX protease self-immunity; Region: Abi; pfam02517 292563003500 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 292563003501 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 292563003502 dimer interface [polypeptide binding]; other site 292563003503 catalytic triad [active] 292563003504 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292563003505 S-adenosylmethionine binding site [chemical binding]; other site 292563003506 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 292563003507 Protein of unknown function (DUF3727); Region: DUF3727; pfam12527 292563003508 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 292563003509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563003510 active site 292563003511 phosphorylation site [posttranslational modification] 292563003512 intermolecular recognition site; other site 292563003513 dimerization interface [polypeptide binding]; other site 292563003514 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 292563003515 DNA binding site [nucleotide binding] 292563003516 photosystem II reaction center I protein I; Provisional; Region: psbI; PRK02655 292563003517 DNA-directed RNA polymerase subunit omega; Provisional; Region: ycf61; CHL00191 292563003518 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 292563003519 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 292563003520 quinone interaction residues [chemical binding]; other site 292563003521 active site 292563003522 catalytic residues [active] 292563003523 FMN binding site [chemical binding]; other site 292563003524 substrate binding site [chemical binding]; other site 292563003525 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 292563003526 adenylosuccinate lyase; Provisional; Region: PRK07380 292563003527 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 292563003528 tetramer interface [polypeptide binding]; other site 292563003529 active site 292563003530 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 292563003531 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 292563003532 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 292563003533 putative active site [active] 292563003534 oxyanion strand; other site 292563003535 catalytic triad [active] 292563003536 PsaD; Region: PsaD; pfam02531 292563003537 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 292563003538 Cysteine-rich domain; Region: CCG; pfam02754 292563003539 Cysteine-rich domain; Region: CCG; pfam02754 292563003540 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 292563003541 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 292563003542 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 292563003543 bifunctional sterol desaturase/short chain dehydrogenase; Validated; Region: PRK07424 292563003544 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 292563003545 short chain dehydrogenase; Provisional; Region: PRK12367 292563003546 NAD(P) binding site [chemical binding]; other site 292563003547 active site 292563003548 Transposase IS200 like; Region: Y1_Tnp; pfam01797 292563003549 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 292563003550 Probable transposase; Region: OrfB_IS605; pfam01385 292563003551 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 292563003552 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 292563003553 HSP70 interaction site [polypeptide binding]; other site 292563003554 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563003555 TPR motif; other site 292563003556 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 292563003557 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 292563003558 dimer interface [polypeptide binding]; other site 292563003559 motif 1; other site 292563003560 active site 292563003561 motif 2; other site 292563003562 motif 3; other site 292563003563 Exopolysaccharide synthesis, ExoD; Region: ExoD; cl01617 292563003564 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 292563003565 Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases; Region: MORN; smart00698 292563003566 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 292563003567 MORN repeat; Region: MORN; cl14787 292563003568 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 292563003569 MORN repeat; Region: MORN; cl14787 292563003570 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 292563003571 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 292563003572 dimer interface [polypeptide binding]; other site 292563003573 [2Fe-2S] cluster binding site [ion binding]; other site 292563003574 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 292563003575 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 292563003576 N-terminal plug; other site 292563003577 ligand-binding site [chemical binding]; other site 292563003578 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 292563003579 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 292563003580 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 292563003581 hydrolase, alpha/beta fold family protein; Region: PLN02824 292563003582 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 292563003583 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 292563003584 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 292563003585 PYR/PP interface [polypeptide binding]; other site 292563003586 dimer interface [polypeptide binding]; other site 292563003587 TPP binding site [chemical binding]; other site 292563003588 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 292563003589 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 292563003590 TPP-binding site [chemical binding]; other site 292563003591 dimer interface [polypeptide binding]; other site 292563003592 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 292563003593 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 292563003594 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 292563003595 Exoribonuclease R [Transcription]; Region: VacB; COG0557 292563003596 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 292563003597 RNB domain; Region: RNB; pfam00773 292563003598 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 292563003599 RNA binding site [nucleotide binding]; other site 292563003600 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 292563003601 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 292563003602 Walker A motif; other site 292563003603 ATP binding site [chemical binding]; other site 292563003604 Walker B motif; other site 292563003605 phosphate transporter ATP-binding protein; Provisional; Region: PRK14243 292563003606 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 292563003607 Walker A/P-loop; other site 292563003608 ATP binding site [chemical binding]; other site 292563003609 Q-loop/lid; other site 292563003610 ABC transporter signature motif; other site 292563003611 Walker B; other site 292563003612 D-loop; other site 292563003613 H-loop/switch region; other site 292563003614 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 292563003615 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 292563003616 putative metal binding site; other site 292563003617 Tetratricopeptide repeat; Region: TPR_12; pfam13424 292563003618 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563003619 binding surface 292563003620 TPR repeat; Region: TPR_11; pfam13414 292563003621 TPR motif; other site 292563003622 TPR repeat; Region: TPR_11; pfam13414 292563003623 hydrolase, alpha/beta fold family protein; Region: PLN02824 292563003624 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 292563003625 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 292563003626 SnoaL-like domain; Region: SnoaL_3; pfam13474 292563003627 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 292563003628 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 292563003629 active site 292563003630 catalytic site [active] 292563003631 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 292563003632 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 292563003633 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 292563003634 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 292563003635 RNA binding surface [nucleotide binding]; other site 292563003636 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 292563003637 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 292563003638 Walker A motif; other site 292563003639 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 292563003640 protein-splicing catalytic site; other site 292563003641 thioester formation/cholesterol transfer; other site 292563003642 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 292563003643 non-specific DNA binding site [nucleotide binding]; other site 292563003644 salt bridge; other site 292563003645 sequence-specific DNA binding site [nucleotide binding]; other site 292563003646 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 292563003647 protein-splicing catalytic site; other site 292563003648 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 292563003649 Walker B motif; other site 292563003650 DNA binding loops [nucleotide binding] 292563003651 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 292563003652 protein-splicing catalytic site; other site 292563003653 thioester formation/cholesterol transfer; other site 292563003654 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 292563003655 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 292563003656 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 292563003657 MOSC domain; Region: MOSC; pfam03473 292563003658 recombination protein F; Reviewed; Region: recF; PRK00064 292563003659 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 292563003660 Walker A/P-loop; other site 292563003661 ATP binding site [chemical binding]; other site 292563003662 Q-loop/lid; other site 292563003663 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292563003664 ABC transporter signature motif; other site 292563003665 Walker B; other site 292563003666 D-loop; other site 292563003667 H-loop/switch region; other site 292563003668 Response regulator receiver domain; Region: Response_reg; pfam00072 292563003669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563003670 active site 292563003671 phosphorylation site [posttranslational modification] 292563003672 intermolecular recognition site; other site 292563003673 dimerization interface [polypeptide binding]; other site 292563003674 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 292563003675 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 292563003676 metal binding site [ion binding]; metal-binding site 292563003677 active site 292563003678 I-site; other site 292563003679 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 292563003680 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 292563003681 putative active site [active] 292563003682 catalytic site [active] 292563003683 putative metal binding site [ion binding]; other site 292563003684 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 292563003685 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 292563003686 catalytic site [active] 292563003687 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 292563003688 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 292563003689 catalytic site [active] 292563003690 putative active site [active] 292563003691 putative substrate binding site [chemical binding]; other site 292563003692 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 292563003693 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 292563003694 putative ADP-binding pocket [chemical binding]; other site 292563003695 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 292563003696 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 292563003697 twin arginine translocase protein A; Provisional; Region: tatA; PRK14857 292563003698 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 292563003699 photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624 292563003700 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 292563003701 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 292563003702 NADP-binding site; other site 292563003703 homotetramer interface [polypeptide binding]; other site 292563003704 substrate binding site [chemical binding]; other site 292563003705 homodimer interface [polypeptide binding]; other site 292563003706 active site 292563003707 Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035 292563003708 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 292563003709 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 292563003710 Uncharacterized conserved protein [Function unknown]; Region: COG1543 292563003711 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 292563003712 active site 292563003713 substrate binding site [chemical binding]; other site 292563003714 catalytic site [active] 292563003715 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 292563003716 UreD urease accessory protein; Region: UreD; cl00530 292563003717 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 292563003718 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 292563003719 heme binding site [chemical binding]; other site 292563003720 ferroxidase pore; other site 292563003721 ferroxidase diiron center [ion binding]; other site 292563003722 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 292563003723 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 292563003724 heme binding site [chemical binding]; other site 292563003725 ferroxidase pore; other site 292563003726 ferroxidase diiron center [ion binding]; other site 292563003727 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 292563003728 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 292563003729 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 292563003730 NAD binding site [chemical binding]; other site 292563003731 dimer interface [polypeptide binding]; other site 292563003732 substrate binding site [chemical binding]; other site 292563003733 tetramer (dimer of dimers) interface [polypeptide binding]; other site 292563003734 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 292563003735 putative hydrophobic ligand binding site [chemical binding]; other site 292563003736 NlpC/P60 family; Region: NLPC_P60; pfam00877 292563003737 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 292563003738 bile acid transporter; Region: bass; TIGR00841 292563003739 Sodium Bile acid symporter family; Region: SBF; cl17470 292563003740 Transposase IS200 like; Region: Y1_Tnp; cl00848 292563003741 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 292563003742 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 292563003743 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 292563003744 substrate binding pocket [chemical binding]; other site 292563003745 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 292563003746 B12 binding site [chemical binding]; other site 292563003747 cobalt ligand [ion binding]; other site 292563003748 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 292563003749 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 292563003750 PBP superfamily domain; Region: PBP_like_2; cl17296 292563003751 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 292563003752 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 292563003753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 292563003754 dimer interface [polypeptide binding]; other site 292563003755 conserved gate region; other site 292563003756 putative PBP binding loops; other site 292563003757 ABC-ATPase subunit interface; other site 292563003758 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 292563003759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 292563003760 dimer interface [polypeptide binding]; other site 292563003761 conserved gate region; other site 292563003762 putative PBP binding loops; other site 292563003763 ABC-ATPase subunit interface; other site 292563003764 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 292563003765 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 292563003766 Walker A/P-loop; other site 292563003767 ATP binding site [chemical binding]; other site 292563003768 Q-loop/lid; other site 292563003769 ABC transporter signature motif; other site 292563003770 Walker B; other site 292563003771 D-loop; other site 292563003772 H-loop/switch region; other site 292563003773 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 292563003774 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563003775 active site 292563003776 phosphorylation site [posttranslational modification] 292563003777 intermolecular recognition site; other site 292563003778 dimerization interface [polypeptide binding]; other site 292563003779 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 292563003780 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 292563003781 hexamer interface [polypeptide binding]; other site 292563003782 ligand binding site [chemical binding]; other site 292563003783 putative active site [active] 292563003784 NAD(P) binding site [chemical binding]; other site 292563003785 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 292563003786 Mechanosensitive ion channel; Region: MS_channel; pfam00924 292563003787 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 292563003788 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 292563003789 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 292563003790 putative dimerization interface [polypeptide binding]; other site 292563003791 Predicted membrane protein [Function unknown]; Region: COG4094 292563003792 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 292563003793 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 292563003794 catalytic residues [active] 292563003795 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 292563003796 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 292563003797 active site 292563003798 (T/H)XGH motif; other site 292563003799 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 292563003800 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 292563003801 putative active site [active] 292563003802 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 292563003803 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 292563003804 active site 292563003805 motif I; other site 292563003806 motif II; other site 292563003807 NAD synthetase; Provisional; Region: PRK13981 292563003808 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 292563003809 multimer interface [polypeptide binding]; other site 292563003810 active site 292563003811 catalytic triad [active] 292563003812 protein interface 1 [polypeptide binding]; other site 292563003813 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 292563003814 homodimer interface [polypeptide binding]; other site 292563003815 NAD binding pocket [chemical binding]; other site 292563003816 ATP binding pocket [chemical binding]; other site 292563003817 Mg binding site [ion binding]; other site 292563003818 active-site loop [active] 292563003819 Repair protein; Region: Repair_PSII; pfam04536 292563003820 Uncharacterized conserved protein [Function unknown]; Region: COG4983 292563003821 Protein of unknown function (DUF3571); Region: DUF3571; pfam12095 292563003822 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 292563003823 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 292563003824 putative substrate translocation pore; other site 292563003825 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 292563003826 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 292563003827 Malic enzyme, N-terminal domain; Region: malic; pfam00390 292563003828 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 292563003829 putative NAD(P) binding site [chemical binding]; other site 292563003830 ribosomal protein S14; Region: rps14; CHL00074 292563003831 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 292563003832 HetN oxidoreductase-like, classical (c) SDR; Region: HetN_like_SDR_c; cd08932 292563003833 putative NAD(P) binding site [chemical binding]; other site 292563003834 active site 292563003835 HicB family; Region: HicB; pfam05534 292563003836 PIN domain; Region: PIN_3; pfam13470 292563003837 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 292563003838 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 292563003839 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563003840 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563003841 Protein of unknown function (DUF938); Region: DUF938; pfam06080 292563003842 GTP-binding protein Der; Reviewed; Region: PRK00093 292563003843 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 292563003844 G1 box; other site 292563003845 GTP/Mg2+ binding site [chemical binding]; other site 292563003846 Switch I region; other site 292563003847 G2 box; other site 292563003848 Switch II region; other site 292563003849 G3 box; other site 292563003850 G4 box; other site 292563003851 G5 box; other site 292563003852 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 292563003853 G1 box; other site 292563003854 GTP/Mg2+ binding site [chemical binding]; other site 292563003855 Switch I region; other site 292563003856 G2 box; other site 292563003857 G3 box; other site 292563003858 Switch II region; other site 292563003859 G4 box; other site 292563003860 G5 box; other site 292563003861 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 292563003862 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 292563003863 tRNA; other site 292563003864 putative tRNA binding site [nucleotide binding]; other site 292563003865 putative NADP binding site [chemical binding]; other site 292563003866 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 292563003867 MAPEG family; Region: MAPEG; pfam01124 292563003868 Cytochrome c; Region: Cytochrom_C; cl11414 292563003869 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 292563003870 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 292563003871 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 292563003872 active site 292563003873 catalytic tetrad [active] 292563003874 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 292563003875 MgtC family; Region: MgtC; pfam02308 292563003876 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 292563003877 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 292563003878 active site 292563003879 catalytic triad [active] 292563003880 oxyanion hole [active] 292563003881 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 292563003882 MgtE intracellular N domain; Region: MgtE_N; smart00924 292563003883 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 292563003884 Divalent cation transporter; Region: MgtE; pfam01769 292563003885 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 292563003886 MgtE intracellular N domain; Region: MgtE_N; smart00924 292563003887 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 292563003888 Divalent cation transporter; Region: MgtE; pfam01769 292563003889 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 292563003890 active site 292563003891 NTP binding site [chemical binding]; other site 292563003892 metal binding triad [ion binding]; metal-binding site 292563003893 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 292563003894 Probable transposase; Region: OrfB_IS605; pfam01385 292563003895 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 292563003896 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 292563003897 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 292563003898 dimer interface [polypeptide binding]; other site 292563003899 active site 292563003900 metal binding site [ion binding]; metal-binding site 292563003901 glutathione binding site [chemical binding]; other site 292563003902 MraW methylase family; Region: Methyltransf_5; cl17771 292563003903 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 292563003904 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 292563003905 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 292563003906 dimer interface [polypeptide binding]; other site 292563003907 conserved gate region; other site 292563003908 putative PBP binding loops; other site 292563003909 ABC-ATPase subunit interface; other site 292563003910 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 292563003911 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 292563003912 Ferredoxin [Energy production and conversion]; Region: COG1146 292563003913 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 292563003914 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 292563003915 YciI-like protein; Reviewed; Region: PRK12864 292563003916 6-phosphofructokinase; Provisional; Region: PRK03202 292563003917 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 292563003918 active site 292563003919 ADP/pyrophosphate binding site [chemical binding]; other site 292563003920 dimerization interface [polypeptide binding]; other site 292563003921 allosteric effector site; other site 292563003922 fructose-1,6-bisphosphate binding site; other site 292563003923 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 292563003924 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 292563003925 phosphate binding site [ion binding]; other site 292563003926 putative substrate binding pocket [chemical binding]; other site 292563003927 dimer interface [polypeptide binding]; other site 292563003928 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 292563003929 TrkA-N domain; Region: TrkA_N; pfam02254 292563003930 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 292563003931 TrkA-N domain; Region: TrkA_N; pfam02254 292563003932 arogenate dehydrogenase; Reviewed; Region: PRK07417 292563003933 prephenate dehydrogenase; Validated; Region: PRK08507 292563003934 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 292563003935 Response regulator receiver domain; Region: Response_reg; pfam00072 292563003936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563003937 active site 292563003938 phosphorylation site [posttranslational modification] 292563003939 intermolecular recognition site; other site 292563003940 dimerization interface [polypeptide binding]; other site 292563003941 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 292563003942 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563003943 active site 292563003944 phosphorylation site [posttranslational modification] 292563003945 intermolecular recognition site; other site 292563003946 dimerization interface [polypeptide binding]; other site 292563003947 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 292563003948 Mrr N-terminal domain; Region: Mrr_N; pfam14338 292563003949 Restriction endonuclease; Region: Mrr_cat; pfam04471 292563003950 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 292563003951 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 292563003952 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 292563003953 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 292563003954 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 292563003955 active site 292563003956 HIGH motif; other site 292563003957 dimer interface [polypeptide binding]; other site 292563003958 KMSKS motif; other site 292563003959 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 292563003960 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 292563003961 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 292563003962 Ligand Binding Site [chemical binding]; other site 292563003963 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 292563003964 Ligand Binding Site [chemical binding]; other site 292563003965 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 292563003966 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360 292563003967 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 292563003968 nucleotide binding site/active site [active] 292563003969 HIT family signature motif; other site 292563003970 catalytic residue [active] 292563003971 ATP adenylyltransferase; Region: ATP_transf; pfam09830 292563003972 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 292563003973 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 292563003974 active site 292563003975 substrate binding site [chemical binding]; other site 292563003976 metal binding site [ion binding]; metal-binding site 292563003977 E3 Ubiquitin ligase; Region: GIDE; pfam12483 292563003978 dihydrodipicolinate reductase; Provisional; Region: PRK00048 292563003979 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 292563003980 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 292563003981 YacP-like NYN domain; Region: NYN_YacP; pfam05991 292563003982 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 292563003983 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 292563003984 active site 292563003985 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 292563003986 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 292563003987 putative ligand binding site [chemical binding]; other site 292563003988 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 292563003989 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 292563003990 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 292563003991 RNA polymerase sigma factor RpoD; Validated; Region: PRK07406 292563003992 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 292563003993 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 292563003994 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 292563003995 DNA binding residues [nucleotide binding] 292563003996 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 292563003997 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 292563003998 NADP-binding site; other site 292563003999 homotetramer interface [polypeptide binding]; other site 292563004000 substrate binding site [chemical binding]; other site 292563004001 homodimer interface [polypeptide binding]; other site 292563004002 active site 292563004003 antitoxin MqsA for MqsR toxin; Region: MqsA; cl15819 292563004004 toxin interface [polypeptide binding]; other site 292563004005 Zn binding site [ion binding]; other site 292563004006 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 292563004007 HAS barrel domain; Region: HAS-barrel; pfam09378 292563004008 HerA helicase [Replication, recombination, and repair]; Region: COG0433 292563004009 Domain of unknown function DUF87; Region: DUF87; pfam01935 292563004010 DNA polymerase III subunit alpha; Reviewed; Region: PRK09532 292563004011 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 292563004012 active site 292563004013 PHP Thumb interface [polypeptide binding]; other site 292563004014 metal binding site [ion binding]; metal-binding site 292563004015 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 292563004016 protein-splicing catalytic site; other site 292563004017 thioester formation/cholesterol transfer; other site 292563004018 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 292563004019 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 292563004020 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 292563004021 putative catalytic cysteine [active] 292563004022 Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655 292563004023 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 292563004024 SmpB-tmRNA interface; other site 292563004025 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 292563004026 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 292563004027 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 292563004028 putative active site [active] 292563004029 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 292563004030 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 292563004031 active site 292563004032 interdomain interaction site; other site 292563004033 putative metal-binding site [ion binding]; other site 292563004034 nucleotide binding site [chemical binding]; other site 292563004035 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 292563004036 domain I; other site 292563004037 phosphate binding site [ion binding]; other site 292563004038 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 292563004039 domain II; other site 292563004040 domain III; other site 292563004041 nucleotide binding site [chemical binding]; other site 292563004042 DNA binding groove [nucleotide binding] 292563004043 catalytic site [active] 292563004044 domain IV; other site 292563004045 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 292563004046 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 292563004047 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 292563004048 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 292563004049 YcfA-like protein; Region: YcfA; pfam07927 292563004050 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 292563004051 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 292563004052 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 292563004053 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 292563004054 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 292563004055 Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474 292563004056 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 292563004057 Na binding site [ion binding]; other site 292563004058 putative glycosylation site [posttranslational modification]; other site 292563004059 putative glycosylation site [posttranslational modification]; other site 292563004060 hydrogenase accessory protein HypB; Region: hypB; TIGR00073 292563004061 hydrogenase nickel insertion protein HypA; Region: hypA; TIGR00100 292563004062 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 292563004063 agmatinase; Region: agmatinase; TIGR01230 292563004064 Agmatinase-like family; Region: Agmatinase-like; cd09990 292563004065 active site 292563004066 oligomer interface [polypeptide binding]; other site 292563004067 Mn binding site [ion binding]; other site 292563004068 Predicted transcriptional regulators [Transcription]; Region: COG1725 292563004069 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 292563004070 DNA-binding site [nucleotide binding]; DNA binding site 292563004071 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 292563004072 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 292563004073 transmembrane helices; other site 292563004074 dihydroorotase; Provisional; Region: PRK07575 292563004075 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 292563004076 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 292563004077 active site 292563004078 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 292563004079 metal-binding site [ion binding] 292563004080 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 292563004081 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 292563004082 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 292563004083 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 292563004084 Walker A/P-loop; other site 292563004085 ATP binding site [chemical binding]; other site 292563004086 Q-loop/lid; other site 292563004087 ABC transporter signature motif; other site 292563004088 Walker B; other site 292563004089 D-loop; other site 292563004090 H-loop/switch region; other site 292563004091 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 292563004092 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 292563004093 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 292563004094 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292563004095 S-adenosylmethionine binding site [chemical binding]; other site 292563004096 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 292563004097 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 292563004098 Walker A motif; other site 292563004099 ATP binding site [chemical binding]; other site 292563004100 Uncharacterized conserved protein [Function unknown]; Region: COG1479 292563004101 Protein of unknown function DUF262; Region: DUF262; pfam03235 292563004102 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 292563004103 Band_7_prohibitin. A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup group includes proteins similar to prohibitin (a lipid raft-associated integral membrane protein). Individual proteins of this band 7 domain family may...; Region: Band_7_prohibitin; cd03401 292563004104 HflK protein; Region: hflK; TIGR01933 292563004105 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 292563004106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563004107 active site 292563004108 phosphorylation site [posttranslational modification] 292563004109 intermolecular recognition site; other site 292563004110 dimerization interface [polypeptide binding]; other site 292563004111 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 292563004112 DNA binding residues [nucleotide binding] 292563004113 dimerization interface [polypeptide binding]; other site 292563004114 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 292563004115 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 292563004116 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 292563004117 Walker A/P-loop; other site 292563004118 ATP binding site [chemical binding]; other site 292563004119 Q-loop/lid; other site 292563004120 ABC transporter signature motif; other site 292563004121 Walker B; other site 292563004122 D-loop; other site 292563004123 H-loop/switch region; other site 292563004124 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 292563004125 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 292563004126 Walker A/P-loop; other site 292563004127 ATP binding site [chemical binding]; other site 292563004128 Q-loop/lid; other site 292563004129 ABC transporter signature motif; other site 292563004130 Walker B; other site 292563004131 D-loop; other site 292563004132 H-loop/switch region; other site 292563004133 tellurium resistance terB-like protein; Region: terB_like; cd07177 292563004134 metal binding site [ion binding]; metal-binding site 292563004135 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 292563004136 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 292563004137 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 292563004138 dimerization interface [polypeptide binding]; other site 292563004139 putative DNA binding site [nucleotide binding]; other site 292563004140 putative Zn2+ binding site [ion binding]; other site 292563004141 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 292563004142 active site 292563004143 SAM binding site [chemical binding]; other site 292563004144 homodimer interface [polypeptide binding]; other site 292563004145 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 292563004146 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563004147 active site 292563004148 phosphorylation site [posttranslational modification] 292563004149 intermolecular recognition site; other site 292563004150 dimerization interface [polypeptide binding]; other site 292563004151 DNA photolyase; Region: DNA_photolyase; pfam00875 292563004152 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765 292563004153 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 292563004154 AAA domain; Region: AAA_18; pfam13238 292563004155 ligand-binding site [chemical binding]; other site 292563004156 Integral membrane protein DUF92; Region: DUF92; pfam01940 292563004157 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 292563004158 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 292563004159 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 292563004160 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 292563004161 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 292563004162 Soluble P-type ATPase [General function prediction only]; Region: COG4087 292563004163 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 292563004164 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 292563004165 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 292563004166 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563004167 active site 292563004168 phosphorylation site [posttranslational modification] 292563004169 intermolecular recognition site; other site 292563004170 dimerization interface [polypeptide binding]; other site 292563004171 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 292563004172 DNA binding site [nucleotide binding] 292563004173 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 292563004174 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 292563004175 Mg++ binding site [ion binding]; other site 292563004176 putative catalytic motif [active] 292563004177 putative substrate binding site [chemical binding]; other site 292563004178 ribonuclease Z; Region: RNase_Z; TIGR02651 292563004179 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 292563004180 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 292563004181 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 292563004182 TrkA-N domain; Region: TrkA_N; pfam02254 292563004183 TrkA-C domain; Region: TrkA_C; pfam02080 292563004184 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 292563004185 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 292563004186 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 292563004187 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 292563004188 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 292563004189 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 292563004190 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 292563004191 cofactor binding site; other site 292563004192 DNA binding site [nucleotide binding] 292563004193 substrate interaction site [chemical binding]; other site 292563004194 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 292563004195 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 292563004196 active site 292563004197 dimerization interface [polypeptide binding]; other site 292563004198 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 292563004199 Low molecular weight phosphatase family; Region: LMWPc; cd00115 292563004200 active site 292563004201 hypothetical protein; Validated; Region: PRK00153 292563004202 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 292563004203 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 292563004204 methionine sulfoxide reductase A; Provisional; Region: PRK00058 292563004205 elongation factor G; Reviewed; Region: PRK00007 292563004206 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 292563004207 G1 box; other site 292563004208 putative GEF interaction site [polypeptide binding]; other site 292563004209 GTP/Mg2+ binding site [chemical binding]; other site 292563004210 Switch I region; other site 292563004211 G2 box; other site 292563004212 G3 box; other site 292563004213 Switch II region; other site 292563004214 G4 box; other site 292563004215 G5 box; other site 292563004216 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 292563004217 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 292563004218 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 292563004219 CAAX protease self-immunity; Region: Abi; pfam02517 292563004220 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 292563004221 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 292563004222 nitrilase; Region: PLN02798 292563004223 putative active site [active] 292563004224 catalytic triad [active] 292563004225 dimer interface [polypeptide binding]; other site 292563004226 putative hydrolase; Provisional; Region: PRK11460 292563004227 Predicted esterase [General function prediction only]; Region: COG0400 292563004228 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 292563004229 catalytic site [active] 292563004230 putative active site [active] 292563004231 putative substrate binding site [chemical binding]; other site 292563004232 FOG: WD40 repeat [General function prediction only]; Region: COG2319 292563004233 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 292563004234 structural tetrad; other site 292563004235 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 292563004236 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 292563004237 Walker A/P-loop; other site 292563004238 ATP binding site [chemical binding]; other site 292563004239 Q-loop/lid; other site 292563004240 ABC transporter signature motif; other site 292563004241 Walker B; other site 292563004242 D-loop; other site 292563004243 H-loop/switch region; other site 292563004244 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 292563004245 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 292563004246 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 292563004247 substrate binding site [chemical binding]; other site 292563004248 glutamase interaction surface [polypeptide binding]; other site 292563004249 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 292563004250 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 292563004251 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 292563004252 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 292563004253 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 292563004254 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 292563004255 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 292563004256 Cell division protein FtsA; Region: FtsA; cl17206 292563004257 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 292563004258 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 292563004259 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 292563004260 putative ADP-binding pocket [chemical binding]; other site 292563004261 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 292563004262 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 292563004263 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 292563004264 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 292563004265 active site 292563004266 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 292563004267 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 292563004268 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 292563004269 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 292563004270 catalytic loop [active] 292563004271 iron binding site [ion binding]; other site 292563004272 shikimate kinase; Reviewed; Region: aroK; PRK00131 292563004273 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 292563004274 ADP binding site [chemical binding]; other site 292563004275 magnesium binding site [ion binding]; other site 292563004276 putative shikimate binding site; other site 292563004277 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 292563004278 catalytic center binding site [active] 292563004279 ATP binding site [chemical binding]; other site 292563004280 HEAT repeats; Region: HEAT_2; pfam13646 292563004281 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 292563004282 HEAT repeats; Region: HEAT_2; pfam13646 292563004283 HEAT repeats; Region: HEAT_2; pfam13646 292563004284 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 292563004285 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 292563004286 active site 292563004287 metal binding site [ion binding]; metal-binding site 292563004288 Protein of unknown function (DUF2396); Region: DUF2396; pfam09654 292563004289 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 292563004290 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 292563004291 Protein of unknown function (DUF512); Region: DUF512; pfam04459 292563004292 Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718 292563004293 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 292563004294 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 292563004295 active site 292563004296 NTP binding site [chemical binding]; other site 292563004297 metal binding triad [ion binding]; metal-binding site 292563004298 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 292563004299 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 292563004300 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 292563004301 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 292563004302 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 292563004303 substrate binding site [chemical binding]; other site 292563004304 oxyanion hole (OAH) forming residues; other site 292563004305 trimer interface [polypeptide binding]; other site 292563004306 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 292563004307 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 292563004308 Catalytic site [active] 292563004309 Yip1 domain; Region: Yip1; pfam04893 292563004310 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 292563004311 Double zinc ribbon; Region: DZR; pfam12773 292563004312 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563004313 TPR repeat; Region: TPR_11; pfam13414 292563004314 binding surface 292563004315 TPR motif; other site 292563004316 TPR repeat; Region: TPR_11; pfam13414 292563004317 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563004318 binding surface 292563004319 TPR motif; other site 292563004320 Tetratricopeptide repeat; Region: TPR_12; pfam13424 292563004321 Tetratricopeptide repeat; Region: TPR_12; pfam13424 292563004322 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563004323 binding surface 292563004324 TPR motif; other site 292563004325 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 292563004326 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 292563004327 homoserine kinase; Provisional; Region: PRK01212 292563004328 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 292563004329 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 292563004330 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 292563004331 active site 292563004332 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 292563004333 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 292563004334 Circadian oscillating protein COP23; Region: COP23; pfam14218 292563004335 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 292563004336 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 292563004337 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 292563004338 Walker A motif; other site 292563004339 ATP binding site [chemical binding]; other site 292563004340 Walker B motif; other site 292563004341 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 292563004342 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 292563004343 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 292563004344 C-terminal domain interface [polypeptide binding]; other site 292563004345 GSH binding site (G-site) [chemical binding]; other site 292563004346 dimer interface [polypeptide binding]; other site 292563004347 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 292563004348 substrate binding pocket (H-site) [chemical binding]; other site 292563004349 N-terminal domain interface [polypeptide binding]; other site 292563004350 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 292563004351 Probable transposase; Region: OrfB_IS605; pfam01385 292563004352 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 292563004353 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 292563004354 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 292563004355 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645 292563004356 ATP-NAD kinase; Region: NAD_kinase; pfam01513 292563004357 light-harvesting-like protein 3; Provisional; Region: PLN00014 292563004358 PetN; Region: PetN; pfam03742 292563004359 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 292563004360 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 292563004361 HlyD family secretion protein; Region: HlyD_3; pfam13437 292563004362 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 292563004363 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 292563004364 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 292563004365 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 292563004366 putative ribose interaction site [chemical binding]; other site 292563004367 putative ADP binding site [chemical binding]; other site 292563004368 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 292563004369 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 292563004370 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 292563004371 Competence protein; Region: Competence; pfam03772 292563004372 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 292563004373 active site clefts [active] 292563004374 zinc binding site [ion binding]; other site 292563004375 dimer interface [polypeptide binding]; other site 292563004376 NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403 292563004377 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 292563004378 NADH dehydrogenase subunit 6; Region: ndhG; CHL00016 292563004379 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 292563004380 NADH dehydrogenase subunit 4L; Region: ndhE; CHL00015 292563004381 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 292563004382 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292563004383 Walker A/P-loop; other site 292563004384 ATP binding site [chemical binding]; other site 292563004385 Q-loop/lid; other site 292563004386 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292563004387 ABC transporter signature motif; other site 292563004388 Walker B; other site 292563004389 D-loop; other site 292563004390 H-loop/switch region; other site 292563004391 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 292563004392 Horizontally Transferred TransMembrane Domain; Region: HTTM; smart00752 292563004393 Protein of unknown function, DUF393; Region: DUF393; pfam04134 292563004394 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 292563004395 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 292563004396 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 292563004397 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 292563004398 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 292563004399 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 292563004400 active site 292563004401 acyl-CoA synthetase; Validated; Region: PRK05850 292563004402 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 292563004403 acyl-activating enzyme (AAE) consensus motif; other site 292563004404 active site 292563004405 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 292563004406 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 292563004407 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 292563004408 molecular chaperone DnaK; Provisional; Region: PRK13410 292563004409 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 292563004410 nucleotide binding site [chemical binding]; other site 292563004411 NEF interaction site [polypeptide binding]; other site 292563004412 SBD interface [polypeptide binding]; other site 292563004413 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 292563004414 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 292563004415 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 292563004416 homodimer interface [polypeptide binding]; other site 292563004417 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292563004418 catalytic residue [active] 292563004419 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 292563004420 YCII-related domain; Region: YCII; cl00999 292563004421 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 292563004422 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 292563004423 putative active site [active] 292563004424 substrate binding site [chemical binding]; other site 292563004425 putative cosubstrate binding site; other site 292563004426 catalytic site [active] 292563004427 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 292563004428 substrate binding site [chemical binding]; other site 292563004429 HAMP domain; Region: HAMP; pfam00672 292563004430 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292563004431 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 292563004432 putative active site [active] 292563004433 heme pocket [chemical binding]; other site 292563004434 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292563004435 putative active site [active] 292563004436 heme pocket [chemical binding]; other site 292563004437 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 292563004438 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292563004439 putative active site [active] 292563004440 heme pocket [chemical binding]; other site 292563004441 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292563004442 putative active site [active] 292563004443 heme pocket [chemical binding]; other site 292563004444 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 292563004445 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292563004446 dimer interface [polypeptide binding]; other site 292563004447 phosphorylation site [posttranslational modification] 292563004448 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292563004449 ATP binding site [chemical binding]; other site 292563004450 Mg2+ binding site [ion binding]; other site 292563004451 G-X-G motif; other site 292563004452 Response regulator receiver domain; Region: Response_reg; pfam00072 292563004453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563004454 active site 292563004455 phosphorylation site [posttranslational modification] 292563004456 intermolecular recognition site; other site 292563004457 dimerization interface [polypeptide binding]; other site 292563004458 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 292563004459 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 292563004460 FeS/SAM binding site; other site 292563004461 HemN C-terminal domain; Region: HemN_C; pfam06969 292563004462 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 292563004463 Cupin domain; Region: Cupin_2; cl17218 292563004464 SOS regulatory protein LexA; Region: lexA; TIGR00498 292563004465 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 292563004466 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 292563004467 Catalytic site [active] 292563004468 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 292563004469 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 292563004470 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 292563004471 substrate binding site [chemical binding]; other site 292563004472 hexamer interface [polypeptide binding]; other site 292563004473 metal binding site [ion binding]; metal-binding site 292563004474 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 292563004475 homodecamer interface [polypeptide binding]; other site 292563004476 GTP cyclohydrolase I; Provisional; Region: PLN03044 292563004477 active site 292563004478 putative catalytic site residues [active] 292563004479 zinc binding site [ion binding]; other site 292563004480 GTP-CH-I/GFRP interaction surface; other site 292563004481 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 292563004482 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 292563004483 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 292563004484 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 292563004485 active site 292563004486 catalytic residues [active] 292563004487 Clp protease; Region: CLP_protease; pfam00574 292563004488 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 292563004489 oligomer interface [polypeptide binding]; other site 292563004490 active site residues [active] 292563004491 bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477 292563004492 Pantoate-beta-alanine ligase; Region: PanC; cd00560 292563004493 active site 292563004494 ATP-binding site [chemical binding]; other site 292563004495 pantoate-binding site; other site 292563004496 HXXH motif; other site 292563004497 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 292563004498 CMP-binding site; other site 292563004499 The sites determining sugar specificity; other site 292563004500 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319 292563004501 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 292563004502 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 292563004503 dimerization interface [polypeptide binding]; other site 292563004504 active site 292563004505 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 292563004506 Integral membrane protein TerC family; Region: TerC; cl10468 292563004507 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 292563004508 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 292563004509 RNA binding site [nucleotide binding]; other site 292563004510 active site 292563004511 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 292563004512 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 292563004513 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563004514 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563004515 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 292563004516 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563004517 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563004518 Methyltransferase domain; Region: Methyltransf_31; pfam13847 292563004519 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292563004520 S-adenosylmethionine binding site [chemical binding]; other site 292563004521 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 292563004522 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 292563004523 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 292563004524 Hexamer interface [polypeptide binding]; other site 292563004525 Hexagonal pore residue; other site 292563004526 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 292563004527 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 292563004528 Hexamer interface [polypeptide binding]; other site 292563004529 Hexagonal pore residue; other site 292563004530 Phosphotransferase enzyme family; Region: APH; pfam01636 292563004531 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 292563004532 active site 292563004533 ATP binding site [chemical binding]; other site 292563004534 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 292563004535 substrate binding site [chemical binding]; other site 292563004536 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 292563004537 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 292563004538 Probable transposase; Region: OrfB_IS605; pfam01385 292563004539 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 292563004540 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 292563004541 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 292563004542 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 292563004543 HIGH motif; other site 292563004544 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 292563004545 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 292563004546 active site 292563004547 KMSKS motif; other site 292563004548 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 292563004549 tRNA binding surface [nucleotide binding]; other site 292563004550 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 292563004551 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 292563004552 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 292563004553 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 292563004554 active site 292563004555 metal binding site [ion binding]; metal-binding site 292563004556 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292563004557 S-adenosylmethionine binding site [chemical binding]; other site 292563004558 argininosuccinate lyase; Provisional; Region: PRK00855 292563004559 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 292563004560 active sites [active] 292563004561 tetramer interface [polypeptide binding]; other site 292563004562 S-layer homology domain; Region: SLH; pfam00395 292563004563 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 292563004564 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 292563004565 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 292563004566 NAD(P) binding pocket [chemical binding]; other site 292563004567 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292563004568 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 292563004569 Walker A/P-loop; other site 292563004570 ATP binding site [chemical binding]; other site 292563004571 Q-loop/lid; other site 292563004572 ABC transporter signature motif; other site 292563004573 Walker B; other site 292563004574 D-loop; other site 292563004575 H-loop/switch region; other site 292563004576 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 292563004577 binding surface 292563004578 TPR motif; other site 292563004579 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 292563004580 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 292563004581 active site 292563004582 Zn binding site [ion binding]; other site 292563004583 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 292563004584 putative active site [active] 292563004585 arginine decarboxylase; Provisional; Region: PRK05354 292563004586 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 292563004587 active site 292563004588 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 292563004589 catalytic residues [active] 292563004590 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 292563004591 acetylornithine aminotransferase; Provisional; Region: PRK02627 292563004592 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 292563004593 inhibitor-cofactor binding pocket; inhibition site 292563004594 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292563004595 catalytic residue [active] 292563004596 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 292563004597 TrkA-N domain; Region: TrkA_N; pfam02254 292563004598 TrkA-C domain; Region: TrkA_C; pfam02080 292563004599 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 292563004600 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 292563004601 active site 292563004602 HIGH motif; other site 292563004603 dimer interface [polypeptide binding]; other site 292563004604 KMSKS motif; other site 292563004605 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 292563004606 FAD binding site [chemical binding]; other site 292563004607 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 292563004608 ABC1 family; Region: ABC1; pfam03109 292563004609 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 292563004610 active site 292563004611 ATP binding site [chemical binding]; other site 292563004612 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428 292563004613 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 292563004614 dimerization interface [polypeptide binding]; other site 292563004615 active site 292563004616 FOG: CBS domain [General function prediction only]; Region: COG0517 292563004617 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 292563004618 FOG: CBS domain [General function prediction only]; Region: COG0517 292563004619 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 292563004620 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 292563004621 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 292563004622 PAS domain S-box; Region: sensory_box; TIGR00229 292563004623 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292563004624 putative active site [active] 292563004625 heme pocket [chemical binding]; other site 292563004626 PAS domain S-box; Region: sensory_box; TIGR00229 292563004627 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292563004628 putative active site [active] 292563004629 heme pocket [chemical binding]; other site 292563004630 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 292563004631 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 292563004632 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292563004633 dimer interface [polypeptide binding]; other site 292563004634 phosphorylation site [posttranslational modification] 292563004635 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292563004636 ATP binding site [chemical binding]; other site 292563004637 Mg2+ binding site [ion binding]; other site 292563004638 G-X-G motif; other site 292563004639 Response regulator receiver domain; Region: Response_reg; pfam00072 292563004640 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563004641 active site 292563004642 phosphorylation site [posttranslational modification] 292563004643 intermolecular recognition site; other site 292563004644 dimerization interface [polypeptide binding]; other site 292563004645 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 292563004646 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 292563004647 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 292563004648 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 292563004649 Protein of unknown function (DUF497); Region: DUF497; pfam04365 292563004650 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 292563004651 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 292563004652 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 292563004653 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 292563004654 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 292563004655 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 292563004656 putative active site [active] 292563004657 Peptidase family M48; Region: Peptidase_M48; pfam01435 292563004658 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 292563004659 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 292563004660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 292563004661 dimer interface [polypeptide binding]; other site 292563004662 conserved gate region; other site 292563004663 putative PBP binding loops; other site 292563004664 ABC-ATPase subunit interface; other site 292563004665 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 292563004666 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 292563004667 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 292563004668 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 292563004669 G1 box; other site 292563004670 GTP/Mg2+ binding site [chemical binding]; other site 292563004671 Switch I region; other site 292563004672 G2 box; other site 292563004673 Switch II region; other site 292563004674 G3 box; other site 292563004675 G4 box; other site 292563004676 G5 box; other site 292563004677 Domain of unknown function (DUF697); Region: DUF697; pfam05128 292563004678 Predicted permeases [General function prediction only]; Region: COG0679 292563004679 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 292563004680 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 292563004681 PDZ domain associated with archaeal and bacterial M61 glycyl-aminopeptidases. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to...; Region: PDZ_glycyl_aminopeptidase; cd00990 292563004682 protein binding site [polypeptide binding]; other site 292563004683 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 292563004684 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 292563004685 ligand binding site [chemical binding]; other site 292563004686 flexible hinge region; other site 292563004687 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 292563004688 ATP-sulfurylase; Region: ATPS; cd00517 292563004689 active site 292563004690 HXXH motif; other site 292563004691 flexible loop; other site 292563004692 DNA repair protein RadA; Provisional; Region: PRK11823 292563004693 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 292563004694 Walker A motif/ATP binding site; other site 292563004695 ATP binding site [chemical binding]; other site 292563004696 Walker B motif; other site 292563004697 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 292563004698 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 292563004699 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 292563004700 tandem repeat interface [polypeptide binding]; other site 292563004701 oligomer interface [polypeptide binding]; other site 292563004702 active site residues [active] 292563004703 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 292563004704 homotrimer interaction site [polypeptide binding]; other site 292563004705 active site 292563004706 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 292563004707 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 292563004708 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 292563004709 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 292563004710 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 292563004711 dihydrodipicolinate synthase; Region: dapA; TIGR00674 292563004712 dimer interface [polypeptide binding]; other site 292563004713 active site 292563004714 catalytic residue [active] 292563004715 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 292563004716 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 292563004717 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 292563004718 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 292563004719 active site 292563004720 Substrate binding site; other site 292563004721 Mg++ binding site; other site 292563004722 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 292563004723 putative trimer interface [polypeptide binding]; other site 292563004724 putative CoA binding site [chemical binding]; other site 292563004725 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 292563004726 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 292563004727 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 292563004728 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 292563004729 purine monophosphate binding site [chemical binding]; other site 292563004730 dimer interface [polypeptide binding]; other site 292563004731 putative catalytic residues [active] 292563004732 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 292563004733 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 292563004734 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 292563004735 anti sigma factor interaction site; other site 292563004736 regulatory phosphorylation site [posttranslational modification]; other site 292563004737 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 292563004738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 292563004739 dimer interface [polypeptide binding]; other site 292563004740 conserved gate region; other site 292563004741 putative PBP binding loops; other site 292563004742 ABC-ATPase subunit interface; other site 292563004743 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 292563004744 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 292563004745 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563004746 S-layer homology domain; Region: SLH; pfam00395 292563004747 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 292563004748 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 292563004749 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 292563004750 active site 292563004751 Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957 292563004752 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 292563004753 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 292563004754 TPP-binding site [chemical binding]; other site 292563004755 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 292563004756 UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255 292563004757 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 292563004758 NAD binding site [chemical binding]; other site 292563004759 substrate binding site [chemical binding]; other site 292563004760 active site 292563004761 heat shock protein 90; Provisional; Region: PRK05218 292563004762 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292563004763 ATP binding site [chemical binding]; other site 292563004764 Mg2+ binding site [ion binding]; other site 292563004765 G-X-G motif; other site 292563004766 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 292563004767 ligand binding site [chemical binding]; other site 292563004768 Tubulin like; Region: Tubulin_2; pfam13809 292563004769 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 292563004770 cytosine deaminase-like protein; Validated; Region: PRK07583 292563004771 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 292563004772 active site 292563004773 hypothetical protein; Provisional; Region: PRK07394 292563004774 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 292563004775 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 292563004776 HEAT repeats; Region: HEAT_2; pfam13646 292563004777 HEAT repeats; Region: HEAT_2; pfam13646 292563004778 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 292563004779 Amidase; Region: Amidase; pfam01425 292563004780 Response regulator receiver domain; Region: Response_reg; pfam00072 292563004781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563004782 active site 292563004783 phosphorylation site [posttranslational modification] 292563004784 intermolecular recognition site; other site 292563004785 dimerization interface [polypeptide binding]; other site 292563004786 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 292563004787 metal binding site [ion binding]; metal-binding site 292563004788 active site 292563004789 I-site; other site 292563004790 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 292563004791 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 292563004792 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 292563004793 dimerization interface [polypeptide binding]; other site 292563004794 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292563004795 dimer interface [polypeptide binding]; other site 292563004796 phosphorylation site [posttranslational modification] 292563004797 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292563004798 ATP binding site [chemical binding]; other site 292563004799 Mg2+ binding site [ion binding]; other site 292563004800 G-X-G motif; other site 292563004801 Uncharacterized conserved protein [Function unknown]; Region: COG4279 292563004802 SWIM zinc finger; Region: SWIM; pfam04434 292563004803 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 292563004804 putative nucleotide binding site [chemical binding]; other site 292563004805 uridine monophosphate binding site [chemical binding]; other site 292563004806 homohexameric interface [polypeptide binding]; other site 292563004807 ribosome recycling factor; Reviewed; Region: frr; PRK00083 292563004808 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 292563004809 hinge region; other site 292563004810 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 292563004811 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 292563004812 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 292563004813 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 292563004814 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 292563004815 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 292563004816 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 292563004817 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 292563004818 DNA binding residues [nucleotide binding] 292563004819 signal recognition particle protein; Provisional; Region: PRK10867 292563004820 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 292563004821 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 292563004822 P loop; other site 292563004823 GTP binding site [chemical binding]; other site 292563004824 Signal peptide binding domain; Region: SRP_SPB; pfam02978 292563004825 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 292563004826 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 292563004827 DXD motif; other site 292563004828 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 292563004829 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 292563004830 TPP-binding site; other site 292563004831 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 292563004832 PYR/PP interface [polypeptide binding]; other site 292563004833 dimer interface [polypeptide binding]; other site 292563004834 TPP binding site [chemical binding]; other site 292563004835 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 292563004836 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317 292563004837 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 292563004838 active site 292563004839 substrate binding site [chemical binding]; other site 292563004840 metal binding site [ion binding]; metal-binding site 292563004841 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 292563004842 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 292563004843 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 292563004844 DXD motif; other site 292563004845 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 292563004846 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 292563004847 NADH-ubiquinone oxidoreductase chain 4, amino terminus; Region: Oxidored_q5_N; pfam01059 292563004848 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 292563004849 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 292563004850 catalytic triad [active] 292563004851 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 292563004852 Rhomboid family; Region: Rhomboid; pfam01694 292563004853 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 292563004854 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 292563004855 Coenzyme A binding pocket [chemical binding]; other site 292563004856 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 292563004857 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 292563004858 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 292563004859 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619 292563004860 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 292563004861 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 292563004862 Dienelactone hydrolase family; Region: DLH; pfam01738 292563004863 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 292563004864 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 292563004865 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 292563004866 putative metal binding site [ion binding]; other site 292563004867 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07088 292563004868 ATP cone domain; Region: ATP-cone; pfam03477 292563004869 Class I ribonucleotide reductase; Region: RNR_I; cd01679 292563004870 active site 292563004871 dimer interface [polypeptide binding]; other site 292563004872 catalytic residues [active] 292563004873 effector binding site; other site 292563004874 R2 peptide binding site; other site 292563004875 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 292563004876 peptide chain release factor 2; Validated; Region: prfB; PRK00578 292563004877 This domain is found in peptide chain release factors; Region: PCRF; smart00937 292563004878 RF-1 domain; Region: RF-1; pfam00472 292563004879 Predicted flavoprotein [General function prediction only]; Region: COG0431 292563004880 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 292563004881 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 292563004882 Glycoprotease family; Region: Peptidase_M22; pfam00814 292563004883 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 292563004884 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 292563004885 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 292563004886 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 292563004887 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 292563004888 Ferredoxin thioredoxin reductase variable alpha chain; Region: FeThRed_A; pfam02941 292563004889 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 292563004890 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 292563004891 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 292563004892 catalytic residue [active] 292563004893 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 292563004894 Cobalt transport protein; Region: CbiQ; pfam02361 292563004895 MASE1; Region: MASE1; cl17823 292563004896 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 292563004897 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 292563004898 metal binding site [ion binding]; metal-binding site 292563004899 active site 292563004900 I-site; other site 292563004901 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 292563004902 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 292563004903 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292563004904 Walker A/P-loop; other site 292563004905 ATP binding site [chemical binding]; other site 292563004906 Q-loop/lid; other site 292563004907 ABC transporter signature motif; other site 292563004908 Walker B; other site 292563004909 D-loop; other site 292563004910 H-loop/switch region; other site 292563004911 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563004912 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 292563004913 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563004914 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563004915 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563004916 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563004917 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563004918 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 292563004919 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 292563004920 Calmodulin-binding; Region: Enkurin; pfam13864 292563004921 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 292563004922 Domain of unknown function (DUF1815); Region: DUF1815; pfam08844 292563004923 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 292563004924 MutS domain III; Region: MutS_III; pfam05192 292563004925 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 292563004926 Walker A/P-loop; other site 292563004927 ATP binding site [chemical binding]; other site 292563004928 Q-loop/lid; other site 292563004929 ABC transporter signature motif; other site 292563004930 Walker B; other site 292563004931 D-loop; other site 292563004932 H-loop/switch region; other site 292563004933 Smr domain; Region: Smr; pfam01713 292563004934 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 292563004935 active site 292563004936 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 292563004937 active site 292563004938 cytochrome c-550; Provisional; Region: psbV; cl17239 292563004939 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 292563004940 active site 292563004941 NTP binding site [chemical binding]; other site 292563004942 metal binding triad [ion binding]; metal-binding site 292563004943 antibiotic binding site [chemical binding]; other site 292563004944 HEPN domain; Region: HEPN; cl00824 292563004945 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 292563004946 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 292563004947 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 292563004948 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 292563004949 binding surface 292563004950 TPR motif; other site 292563004951 Tetratricopeptide repeat; Region: TPR_12; pfam13424 292563004952 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 292563004953 active site 292563004954 dimer interface [polypeptide binding]; other site 292563004955 metal binding site [ion binding]; metal-binding site 292563004956 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 292563004957 active site 292563004958 catalytic triad [active] 292563004959 oxyanion hole [active] 292563004960 Peptidase family M41; Region: Peptidase_M41; pfam01434 292563004961 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 292563004962 gamma-beta subunit interface [polypeptide binding]; other site 292563004963 alpha-beta subunit interface [polypeptide binding]; other site 292563004964 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 292563004965 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 292563004966 nucleotide binding site [chemical binding]; other site 292563004967 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 292563004968 dimer interface [polypeptide binding]; other site 292563004969 active site 292563004970 aspartate-rich active site metal binding site; other site 292563004971 allosteric magnesium binding site [ion binding]; other site 292563004972 Schiff base residues; other site 292563004973 HAS barrel domain; Region: HAS-barrel; pfam09378 292563004974 Protein of unknown function (DUF2555); Region: DUF2555; pfam10742 292563004975 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 292563004976 Flavoprotein; Region: Flavoprotein; pfam02441 292563004977 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 292563004978 signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705 292563004979 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 292563004980 tandem repeat interface [polypeptide binding]; other site 292563004981 oligomer interface [polypeptide binding]; other site 292563004982 active site residues [active] 292563004983 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 292563004984 tandem repeat interface [polypeptide binding]; other site 292563004985 oligomer interface [polypeptide binding]; other site 292563004986 active site residues [active] 292563004987 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 292563004988 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 292563004989 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 292563004990 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 292563004991 RNA binding site [nucleotide binding]; other site 292563004992 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 292563004993 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 292563004994 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 292563004995 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 292563004996 dimer interface [polypeptide binding]; other site 292563004997 ssDNA binding site [nucleotide binding]; other site 292563004998 tetramer (dimer of dimers) interface [polypeptide binding]; other site 292563004999 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 292563005000 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 292563005001 putative ADP-binding pocket [chemical binding]; other site 292563005002 Bacterial sugar transferase; Region: Bac_transf; pfam02397 292563005003 Protein kinase domain; Region: Pkinase; pfam00069 292563005004 Catalytic domain of Protein Kinases; Region: PKc; cd00180 292563005005 active site 292563005006 ATP binding site [chemical binding]; other site 292563005007 substrate binding site [chemical binding]; other site 292563005008 activation loop (A-loop); other site 292563005009 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 292563005010 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292563005011 Walker A/P-loop; other site 292563005012 ATP binding site [chemical binding]; other site 292563005013 Q-loop/lid; other site 292563005014 ABC transporter signature motif; other site 292563005015 Walker B; other site 292563005016 D-loop; other site 292563005017 H-loop/switch region; other site 292563005018 TOBE domain; Region: TOBE_2; pfam08402 292563005019 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 292563005020 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 292563005021 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 292563005022 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 292563005023 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 292563005024 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 292563005025 KaiA domain; Region: KaiA; pfam07688 292563005026 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 292563005027 tetramer interface [polypeptide binding]; other site 292563005028 dimer interface [polypeptide binding]; other site 292563005029 circadian clock protein KaiC; Region: circ_KaiC; TIGR02655 292563005030 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 292563005031 Walker A motif; other site 292563005032 ATP binding site [chemical binding]; other site 292563005033 Walker B motif; other site 292563005034 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 292563005035 ATP binding site [chemical binding]; other site 292563005036 Walker B motif; other site 292563005037 Bacitracin resistance protein BacA; Region: BacA; pfam02673 292563005038 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 292563005039 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 292563005040 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 292563005041 FeS/SAM binding site; other site 292563005042 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 292563005043 DEAD-like helicases superfamily; Region: DEXDc; smart00487 292563005044 ATP binding site [chemical binding]; other site 292563005045 Mg++ binding site [ion binding]; other site 292563005046 motif III; other site 292563005047 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 292563005048 nucleotide binding region [chemical binding]; other site 292563005049 ATP-binding site [chemical binding]; other site 292563005050 TM2 domain; Region: TM2; cl00984 292563005051 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 292563005052 DNA-binding interface [nucleotide binding]; DNA binding site 292563005053 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 292563005054 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 292563005055 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 292563005056 catalytic site [active] 292563005057 subunit interface [polypeptide binding]; other site 292563005058 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 292563005059 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 292563005060 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292563005061 homodimer interface [polypeptide binding]; other site 292563005062 catalytic residue [active] 292563005063 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 292563005064 IHF dimer interface [polypeptide binding]; other site 292563005065 IHF - DNA interface [nucleotide binding]; other site 292563005066 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 292563005067 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 292563005068 NAD(P) binding site [chemical binding]; other site 292563005069 catalytic residues [active] 292563005070 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 292563005071 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 292563005072 putative DNA binding site [nucleotide binding]; other site 292563005073 putative Zn2+ binding site [ion binding]; other site 292563005074 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 292563005075 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 292563005076 active site 292563005077 S-layer homology domain; Region: SLH; pfam00395 292563005078 S-layer homology domain; Region: SLH; pfam00395 292563005079 S-layer homology domain; Region: SLH; pfam00395 292563005080 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 292563005081 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 292563005082 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 292563005083 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 292563005084 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 292563005085 Probable transposase; Region: OrfB_IS605; pfam01385 292563005086 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 292563005087 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 292563005088 cytochrome c biogenesis protein; Region: ccsA; CHL00045 292563005089 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 292563005090 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 292563005091 putative active site [active] 292563005092 TRAM domain; Region: TRAM; cl01282 292563005093 ABC-2 type transporter; Region: ABC2_membrane; cl17235 292563005094 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 292563005095 hypothetical protein; Validated; Region: PRK07411 292563005096 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 292563005097 ATP binding site [chemical binding]; other site 292563005098 substrate interface [chemical binding]; other site 292563005099 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 292563005100 active site residue [active] 292563005101 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 292563005102 dimerization interface [polypeptide binding]; other site 292563005103 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 292563005104 protein-splicing catalytic site; other site 292563005105 thioester formation/cholesterol transfer; other site 292563005106 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 292563005107 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 292563005108 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 292563005109 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 292563005110 ATP binding site [chemical binding]; other site 292563005111 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 292563005112 dimerization interface [polypeptide binding]; other site 292563005113 ATP binding site [chemical binding]; other site 292563005114 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 292563005115 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563005116 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 292563005117 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563005118 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563005119 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563005120 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563005121 Nucleosome binding factor SPN, SPT16 subunit [Transcription / DNA replication, recombination, and repair / Chromatin structure and dynamics]; Region: COG5406 292563005122 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 292563005123 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 292563005124 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 292563005125 catalytic residue [active] 292563005126 CHRD domain; Region: CHRD; pfam07452 292563005127 9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732 292563005128 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 292563005129 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 292563005130 Sporulation and spore germination; Region: Germane; pfam10646 292563005131 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 292563005132 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 292563005133 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 292563005134 homodimer interface [polypeptide binding]; other site 292563005135 substrate-cofactor binding pocket; other site 292563005136 catalytic residue [active] 292563005137 uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792 292563005138 GTPase Era; Reviewed; Region: era; PRK00089 292563005139 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 292563005140 G1 box; other site 292563005141 GTP/Mg2+ binding site [chemical binding]; other site 292563005142 Switch I region; other site 292563005143 G2 box; other site 292563005144 Switch II region; other site 292563005145 G3 box; other site 292563005146 G4 box; other site 292563005147 G5 box; other site 292563005148 KH domain; Region: KH_2; pfam07650 292563005149 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 292563005150 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563005151 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563005152 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563005153 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563005154 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563005155 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 292563005156 Peptidase family M50; Region: Peptidase_M50; pfam02163 292563005157 active site 292563005158 putative substrate binding region [chemical binding]; other site 292563005159 FOG: CBS domain [General function prediction only]; Region: COG0517 292563005160 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 292563005161 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 292563005162 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 292563005163 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 292563005164 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 292563005165 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 292563005166 PhoH-like protein; Region: PhoH; pfam02562 292563005167 Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase) [Coenzyme metabolism]; Region: CobT; COG4547 292563005168 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 292563005169 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 292563005170 G1 box; other site 292563005171 putative GEF interaction site [polypeptide binding]; other site 292563005172 GTP/Mg2+ binding site [chemical binding]; other site 292563005173 Switch I region; other site 292563005174 G2 box; other site 292563005175 G3 box; other site 292563005176 Switch II region; other site 292563005177 G4 box; other site 292563005178 G5 box; other site 292563005179 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 292563005180 seryl-tRNA synthetase; Provisional; Region: PRK05431 292563005181 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 292563005182 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 292563005183 dimer interface [polypeptide binding]; other site 292563005184 active site 292563005185 motif 1; other site 292563005186 motif 2; other site 292563005187 motif 3; other site 292563005188 Thf1-like protein; Reviewed; Region: PRK13266 292563005189 photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060 292563005190 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 292563005191 putative hydrophobic ligand binding site [chemical binding]; other site 292563005192 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 292563005193 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 292563005194 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 292563005195 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 292563005196 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 292563005197 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 292563005198 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 292563005199 ATP binding site [chemical binding]; other site 292563005200 putative Mg++ binding site [ion binding]; other site 292563005201 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 292563005202 nucleotide binding region [chemical binding]; other site 292563005203 ATP-binding site [chemical binding]; other site 292563005204 Response regulator receiver domain; Region: Response_reg; pfam00072 292563005205 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563005206 active site 292563005207 phosphorylation site [posttranslational modification] 292563005208 intermolecular recognition site; other site 292563005209 dimerization interface [polypeptide binding]; other site 292563005210 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 292563005211 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 292563005212 GAF domain; Region: GAF; pfam01590 292563005213 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292563005214 dimer interface [polypeptide binding]; other site 292563005215 phosphorylation site [posttranslational modification] 292563005216 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292563005217 ATP binding site [chemical binding]; other site 292563005218 Mg2+ binding site [ion binding]; other site 292563005219 G-X-G motif; other site 292563005220 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 292563005221 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 292563005222 catalytic loop [active] 292563005223 iron binding site [ion binding]; other site 292563005224 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 292563005225 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 292563005226 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 292563005227 cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068 292563005228 ATP-grasp domain; Region: ATP-grasp_4; cl17255 292563005229 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 292563005230 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 292563005231 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 292563005232 proposed catalytic triad [active] 292563005233 active site nucleophile [active] 292563005234 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 292563005235 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 292563005236 Rubrerythrin [Energy production and conversion]; Region: COG1592 292563005237 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 292563005238 tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057 292563005239 hypothetical protein; Provisional; Region: PRK04194 292563005240 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 292563005241 catalytic core [active] 292563005242 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 292563005243 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 292563005244 catalytic triad [active] 292563005245 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 292563005246 4Fe-4S binding domain; Region: Fer4_5; pfam12801 292563005247 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 292563005248 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 292563005249 ligand binding site [chemical binding]; other site 292563005250 flexible hinge region; other site 292563005251 Oligomerisation domain; Region: Oligomerisation; pfam02410 292563005252 MoxR-like ATPases [General function prediction only]; Region: COG0714 292563005253 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 292563005254 Walker A motif; other site 292563005255 ATP binding site [chemical binding]; other site 292563005256 Walker B motif; other site 292563005257 arginine finger; other site 292563005258 Ycf39; Provisional; Region: ycf39; CHL00194 292563005259 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 292563005260 NAD(P) binding site [chemical binding]; other site 292563005261 putative active site [active] 292563005262 flavoprotein, HI0933 family; Region: TIGR00275 292563005263 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 292563005264 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 292563005265 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 292563005266 Tetramer interface [polypeptide binding]; other site 292563005267 active site 292563005268 FMN-binding site [chemical binding]; other site 292563005269 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 292563005270 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 292563005271 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 292563005272 Response regulator receiver domain; Region: Response_reg; pfam00072 292563005273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563005274 active site 292563005275 phosphorylation site [posttranslational modification] 292563005276 intermolecular recognition site; other site 292563005277 dimerization interface [polypeptide binding]; other site 292563005278 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 292563005279 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 292563005280 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 292563005281 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 292563005282 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563005283 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563005284 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563005285 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563005286 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563005287 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 292563005288 conserved hypothetical protein; Region: TIGR03492 292563005289 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 292563005290 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563005291 active site 292563005292 phosphorylation site [posttranslational modification] 292563005293 intermolecular recognition site; other site 292563005294 dimerization interface [polypeptide binding]; other site 292563005295 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 292563005296 DNA binding site [nucleotide binding] 292563005297 plastocyanin; Provisional; Region: PRK02710 292563005298 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 292563005299 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 292563005300 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 292563005301 HSP70 interaction site [polypeptide binding]; other site 292563005302 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 292563005303 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 292563005304 dimer interface [polypeptide binding]; other site 292563005305 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292563005306 catalytic residue [active] 292563005307 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 292563005308 Catalytic domain of Protein Kinases; Region: PKc; cd00180 292563005309 active site 292563005310 ATP binding site [chemical binding]; other site 292563005311 substrate binding site [chemical binding]; other site 292563005312 activation loop (A-loop); other site 292563005313 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 292563005314 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766 292563005315 Uncharacterized subfamily of glycoside hydrolase family 57 (GH57); Region: GH57N_like_1; cd10798 292563005316 active site 292563005317 catalytic site [active] 292563005318 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 292563005319 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 292563005320 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 292563005321 UGMP family protein; Validated; Region: PRK09604 292563005322 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 292563005323 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 292563005324 Photosystem I reaction centre subunit IX / PsaJ; Region: PSI_PsaJ; cl03320 292563005325 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403 292563005326 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 292563005327 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 292563005328 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 292563005329 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 292563005330 active site 292563005331 motif I; other site 292563005332 motif II; other site 292563005333 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 292563005334 Bacterial sugar transferase; Region: Bac_transf; pfam02397 292563005335 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 292563005336 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 292563005337 arsenical-resistance protein; Region: acr3; TIGR00832 292563005338 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 292563005339 dimerization interface [polypeptide binding]; other site 292563005340 putative DNA binding site [nucleotide binding]; other site 292563005341 putative Zn2+ binding site [ion binding]; other site 292563005342 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 292563005343 glucosylglycerol-phosphate synthase; Region: gluc_glyc_Psyn; TIGR02398 292563005344 active site 292563005345 homotetramer interface [polypeptide binding]; other site 292563005346 quinolinate synthetase; Provisional; Region: PRK09375 292563005347 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 292563005348 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 292563005349 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 292563005350 Mechanosensitive ion channel; Region: MS_channel; pfam00924 292563005351 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 292563005352 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 292563005353 Probable transposase; Region: OrfB_IS605; pfam01385 292563005354 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 292563005355 active site 292563005356 metal binding site [ion binding]; metal-binding site 292563005357 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 292563005358 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 292563005359 intersubunit interface [polypeptide binding]; other site 292563005360 AMIN domain; Region: AMIN; pfam11741 292563005361 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 292563005362 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 292563005363 N-terminal plug; other site 292563005364 ligand-binding site [chemical binding]; other site 292563005365 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 292563005366 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 292563005367 Walker A/P-loop; other site 292563005368 ATP binding site [chemical binding]; other site 292563005369 Q-loop/lid; other site 292563005370 ABC transporter signature motif; other site 292563005371 Walker B; other site 292563005372 D-loop; other site 292563005373 H-loop/switch region; other site 292563005374 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 292563005375 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 292563005376 ABC-ATPase subunit interface; other site 292563005377 dimer interface [polypeptide binding]; other site 292563005378 putative PBP binding regions; other site 292563005379 GTP-binding protein YchF; Reviewed; Region: PRK09601 292563005380 YchF GTPase; Region: YchF; cd01900 292563005381 G1 box; other site 292563005382 GTP/Mg2+ binding site [chemical binding]; other site 292563005383 Switch I region; other site 292563005384 G2 box; other site 292563005385 Switch II region; other site 292563005386 G3 box; other site 292563005387 G4 box; other site 292563005388 G5 box; other site 292563005389 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 292563005390 Membrane protein of unknown function; Region: DUF360; pfam04020 292563005391 ribosomal protein L32; Validated; Region: rpl32; CHL00152 292563005392 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 292563005393 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 292563005394 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 292563005395 TM-ABC transporter signature motif; other site 292563005396 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 292563005397 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 292563005398 TM-ABC transporter signature motif; other site 292563005399 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 292563005400 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 292563005401 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 292563005402 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 292563005403 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 292563005404 thiS-thiF/thiG interaction site; other site 292563005405 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 292563005406 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 292563005407 active site 292563005408 intersubunit interface [polypeptide binding]; other site 292563005409 catalytic residue [active] 292563005410 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 292563005411 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 292563005412 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 292563005413 Radical SAM superfamily; Region: Radical_SAM; pfam04055 292563005414 FeS/SAM binding site; other site 292563005415 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 292563005416 Family of unknown function (DUF490); Region: DUF490; pfam04357 292563005417 Family of unknown function (DUF490); Region: DUF490; pfam04357 292563005418 Methyltransferase domain; Region: Methyltransf_23; pfam13489 292563005419 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292563005420 S-adenosylmethionine binding site [chemical binding]; other site 292563005421 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 292563005422 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 292563005423 G1 box; other site 292563005424 GTP/Mg2+ binding site [chemical binding]; other site 292563005425 Switch I region; other site 292563005426 G2 box; other site 292563005427 Switch II region; other site 292563005428 G3 box; other site 292563005429 G4 box; other site 292563005430 G5 box; other site 292563005431 Domain of unknown function (DUF697); Region: DUF697; pfam05128 292563005432 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 292563005433 MoaE interaction surface [polypeptide binding]; other site 292563005434 MoeB interaction surface [polypeptide binding]; other site 292563005435 thiocarboxylated glycine; other site 292563005436 threonine synthase; Validated; Region: PRK07591 292563005437 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 292563005438 homodimer interface [polypeptide binding]; other site 292563005439 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292563005440 catalytic residue [active] 292563005441 isoleucyl-tRNA synthetase; Region: PLN02843 292563005442 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 292563005443 HIGH motif; other site 292563005444 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 292563005445 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 292563005446 active site 292563005447 KMSKS motif; other site 292563005448 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 292563005449 tRNA binding surface [nucleotide binding]; other site 292563005450 anticodon binding site; other site 292563005451 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 292563005452 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 292563005453 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 292563005454 cofactor binding site; other site 292563005455 DNA binding site [nucleotide binding] 292563005456 substrate interaction site [chemical binding]; other site 292563005457 imidazoleglycerol-phosphate dehydratase; Region: PLN02800 292563005458 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 292563005459 putative active site pocket [active] 292563005460 4-fold oligomerization interface [polypeptide binding]; other site 292563005461 metal binding residues [ion binding]; metal-binding site 292563005462 3-fold/trimer interface [polypeptide binding]; other site 292563005463 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 292563005464 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 292563005465 DRTGG domain; Region: DRTGG; pfam07085 292563005466 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 292563005467 PLD-like domain; Region: PLDc_2; pfam13091 292563005468 putative active site [active] 292563005469 catalytic site [active] 292563005470 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 292563005471 PLD-like domain; Region: PLDc_2; pfam13091 292563005472 putative active site [active] 292563005473 catalytic site [active] 292563005474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 292563005475 dimer interface [polypeptide binding]; other site 292563005476 putative PBP binding loops; other site 292563005477 ABC-ATPase subunit interface; other site 292563005478 phosphodiesterase; Provisional; Region: PRK12704 292563005479 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 292563005480 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 292563005481 Ligand Binding Site [chemical binding]; other site 292563005482 Uncharacterized conserved protein [Function unknown]; Region: COG3542 292563005483 Domain of unknown function (DUF1868); Region: 2H-phosphodiest; pfam08975 292563005484 precorrin-8X methylmutase; Provisional; Region: PRK05954 292563005485 Precorrin-8X methylmutase; Region: CbiC; pfam02570 292563005486 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 292563005487 histidinol dehydrogenase; Region: hisD; TIGR00069 292563005488 NAD binding site [chemical binding]; other site 292563005489 dimerization interface [polypeptide binding]; other site 292563005490 product binding site; other site 292563005491 substrate binding site [chemical binding]; other site 292563005492 zinc binding site [ion binding]; other site 292563005493 catalytic residues [active] 292563005494 proton extrusion protein PcxA; Provisional; Region: PRK02507 292563005495 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 292563005496 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563005497 active site 292563005498 phosphorylation site [posttranslational modification] 292563005499 intermolecular recognition site; other site 292563005500 dimerization interface [polypeptide binding]; other site 292563005501 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 292563005502 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 292563005503 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 292563005504 dimerization interface [polypeptide binding]; other site 292563005505 DPS ferroxidase diiron center [ion binding]; other site 292563005506 ion pore; other site 292563005507 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 292563005508 nucleoside/Zn binding site; other site 292563005509 dimer interface [polypeptide binding]; other site 292563005510 catalytic motif [active] 292563005511 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 292563005512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563005513 active site 292563005514 phosphorylation site [posttranslational modification] 292563005515 intermolecular recognition site; other site 292563005516 dimerization interface [polypeptide binding]; other site 292563005517 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 292563005518 DNA binding site [nucleotide binding] 292563005519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 292563005520 excinuclease ABC subunit B; Provisional; Region: PRK05298 292563005521 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 292563005522 ATP binding site [chemical binding]; other site 292563005523 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 292563005524 nucleotide binding region [chemical binding]; other site 292563005525 ATP-binding site [chemical binding]; other site 292563005526 Ultra-violet resistance protein B; Region: UvrB; pfam12344 292563005527 UvrB/uvrC motif; Region: UVR; pfam02151 292563005528 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 292563005529 putative active site [active] 292563005530 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 292563005531 putative active site [active] 292563005532 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 292563005533 putative binding surface; other site 292563005534 active site 292563005535 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 292563005536 putative binding surface; other site 292563005537 active site 292563005538 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 292563005539 putative binding surface; other site 292563005540 active site 292563005541 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 292563005542 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 292563005543 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292563005544 ATP binding site [chemical binding]; other site 292563005545 Mg2+ binding site [ion binding]; other site 292563005546 G-X-G motif; other site 292563005547 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 292563005548 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 292563005549 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563005550 active site 292563005551 phosphorylation site [posttranslational modification] 292563005552 intermolecular recognition site; other site 292563005553 dimerization interface [polypeptide binding]; other site 292563005554 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 292563005555 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 292563005556 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 292563005557 NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473 292563005558 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 292563005559 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 292563005560 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 292563005561 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 292563005562 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 292563005563 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 292563005564 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 292563005565 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 292563005566 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 292563005567 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 292563005568 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 292563005569 Cl- selectivity filter; other site 292563005570 Cl- binding residues [ion binding]; other site 292563005571 pore gating glutamate residue; other site 292563005572 dimer interface [polypeptide binding]; other site 292563005573 H+/Cl- coupling transport residue; other site 292563005574 FOG: CBS domain [General function prediction only]; Region: COG0517 292563005575 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 292563005576 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 292563005577 Ligand Binding Site [chemical binding]; other site 292563005578 Universal stress protein family; Region: Usp; pfam00582 292563005579 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 292563005580 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 292563005581 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 292563005582 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 292563005583 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 292563005584 putative dimer interface [polypeptide binding]; other site 292563005585 N-terminal domain interface [polypeptide binding]; other site 292563005586 putative substrate binding pocket (H-site) [chemical binding]; other site 292563005587 acetolactate synthase; Reviewed; Region: PRK08322 292563005588 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 292563005589 PYR/PP interface [polypeptide binding]; other site 292563005590 dimer interface [polypeptide binding]; other site 292563005591 TPP binding site [chemical binding]; other site 292563005592 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 292563005593 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 292563005594 TPP-binding site [chemical binding]; other site 292563005595 dimer interface [polypeptide binding]; other site 292563005596 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 292563005597 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292563005598 dimer interface [polypeptide binding]; other site 292563005599 phosphorylation site [posttranslational modification] 292563005600 Response regulator receiver domain; Region: Response_reg; pfam00072 292563005601 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563005602 active site 292563005603 phosphorylation site [posttranslational modification] 292563005604 intermolecular recognition site; other site 292563005605 dimerization interface [polypeptide binding]; other site 292563005606 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 292563005607 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 292563005608 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 292563005609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563005610 active site 292563005611 phosphorylation site [posttranslational modification] 292563005612 intermolecular recognition site; other site 292563005613 dimerization interface [polypeptide binding]; other site 292563005614 two component system sensor kinase SsrA; Provisional; Region: PRK15347 292563005615 Cache domain; Region: Cache_1; pfam02743 292563005616 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 292563005617 dimerization interface [polypeptide binding]; other site 292563005618 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292563005619 dimer interface [polypeptide binding]; other site 292563005620 phosphorylation site [posttranslational modification] 292563005621 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292563005622 ATP binding site [chemical binding]; other site 292563005623 Mg2+ binding site [ion binding]; other site 292563005624 G-X-G motif; other site 292563005625 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563005626 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 292563005627 active site 292563005628 phosphorylation site [posttranslational modification] 292563005629 intermolecular recognition site; other site 292563005630 dimerization interface [polypeptide binding]; other site 292563005631 Response regulator receiver domain; Region: Response_reg; pfam00072 292563005632 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563005633 active site 292563005634 phosphorylation site [posttranslational modification] 292563005635 intermolecular recognition site; other site 292563005636 dimerization interface [polypeptide binding]; other site 292563005637 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 292563005638 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 292563005639 acyl-activating enzyme (AAE) consensus motif; other site 292563005640 AMP binding site [chemical binding]; other site 292563005641 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 292563005642 thioester reductase domain; Region: Thioester-redct; TIGR01746 292563005643 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 292563005644 putative NAD(P) binding site [chemical binding]; other site 292563005645 active site 292563005646 putative substrate binding site [chemical binding]; other site 292563005647 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 292563005648 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 292563005649 S-layer homology domain; Region: SLH; pfam00395 292563005650 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 292563005651 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 292563005652 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 292563005653 anti sigma factor interaction site; other site 292563005654 regulatory phosphorylation site [posttranslational modification]; other site 292563005655 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 292563005656 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme; Region: E_set_GDE_N; cd11234 292563005657 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 292563005658 active site 292563005659 catalytic site [active] 292563005660 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 292563005661 anti sigma factor interaction site; other site 292563005662 regulatory phosphorylation site [posttranslational modification]; other site 292563005663 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 292563005664 dimerization interface [polypeptide binding]; other site 292563005665 putative active cleft [active] 292563005666 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 292563005667 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 292563005668 conserved cys residue [active] 292563005669 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 292563005670 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 292563005671 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 292563005672 Cupin domain; Region: Cupin_2; cl17218 292563005673 Cupin domain; Region: Cupin_2; pfam07883 292563005674 EthD domain; Region: EthD; pfam07110 292563005675 EthD domain; Region: EthD; cl17553 292563005676 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 292563005677 SnoaL-like domain; Region: SnoaL_2; pfam12680 292563005678 SnoaL-like domain; Region: SnoaL_2; pfam12680 292563005679 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 292563005680 EthD domain; Region: EthD; pfam07110 292563005681 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 292563005682 Cation efflux family; Region: Cation_efflux; cl00316 292563005683 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 292563005684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 292563005685 dimer interface [polypeptide binding]; other site 292563005686 conserved gate region; other site 292563005687 putative PBP binding loops; other site 292563005688 ABC-ATPase subunit interface; other site 292563005689 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 292563005690 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 292563005691 ring oligomerisation interface [polypeptide binding]; other site 292563005692 ATP/Mg binding site [chemical binding]; other site 292563005693 stacking interactions; other site 292563005694 hinge regions; other site 292563005695 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 292563005696 oligomerisation interface [polypeptide binding]; other site 292563005697 mobile loop; other site 292563005698 roof hairpin; other site 292563005699 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 292563005700 CpeS-like protein; Region: CpeS; pfam09367 292563005701 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 292563005702 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 292563005703 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 292563005704 Cytochrome P450; Region: p450; pfam00067 292563005705 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 292563005706 Clp amino terminal domain; Region: Clp_N; pfam02861 292563005707 Clp amino terminal domain; Region: Clp_N; pfam02861 292563005708 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 292563005709 Walker A motif; other site 292563005710 ATP binding site [chemical binding]; other site 292563005711 Walker B motif; other site 292563005712 arginine finger; other site 292563005713 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 292563005714 Walker A motif; other site 292563005715 ATP binding site [chemical binding]; other site 292563005716 Walker B motif; other site 292563005717 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 292563005718 Cupin domain; Region: Cupin_2; cl17218 292563005719 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 292563005720 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 292563005721 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 292563005722 G1 box; other site 292563005723 GTP/Mg2+ binding site [chemical binding]; other site 292563005724 G2 box; other site 292563005725 Switch I region; other site 292563005726 G3 box; other site 292563005727 Switch II region; other site 292563005728 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 292563005729 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 292563005730 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 292563005731 active site 292563005732 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 292563005733 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; cl03326 292563005734 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 292563005735 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 292563005736 Sulfate transporter family; Region: Sulfate_transp; pfam00916 292563005737 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 292563005738 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 292563005739 active site 292563005740 SAM binding site [chemical binding]; other site 292563005741 homodimer interface [polypeptide binding]; other site 292563005742 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 292563005743 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 292563005744 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 292563005745 Coenzyme A binding pocket [chemical binding]; other site 292563005746 5-oxoprolinase; Region: PLN02666 292563005747 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 292563005748 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 292563005749 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 292563005750 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 292563005751 homotrimer interface [polypeptide binding]; other site 292563005752 Walker A motif; other site 292563005753 GTP binding site [chemical binding]; other site 292563005754 Walker B motif; other site 292563005755 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 292563005756 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 292563005757 GIY-YIG motif/motif A; other site 292563005758 active site 292563005759 catalytic site [active] 292563005760 putative DNA binding site [nucleotide binding]; other site 292563005761 metal binding site [ion binding]; metal-binding site 292563005762 UvrB/uvrC motif; Region: UVR; pfam02151 292563005763 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 292563005764 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 292563005765 putative active site [active] 292563005766 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 292563005767 FAD binding domain; Region: FAD_binding_4; pfam01565 292563005768 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 292563005769 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 292563005770 DNA polymerase III subunit delta'; Validated; Region: PRK07399 292563005771 DNA polymerase III subunit delta'; Validated; Region: PRK08485 292563005772 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 292563005773 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 292563005774 putative active site [active] 292563005775 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 292563005776 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 292563005777 ATP binding site [chemical binding]; other site 292563005778 putative Mg++ binding site [ion binding]; other site 292563005779 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 292563005780 nucleotide binding region [chemical binding]; other site 292563005781 ATP-binding site [chemical binding]; other site 292563005782 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 292563005783 HRDC domain; Region: HRDC; pfam00570 292563005784 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 292563005785 putative active site [active] 292563005786 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 292563005787 Catalytic domain of Protein Kinases; Region: PKc; cd00180 292563005788 active site 292563005789 ATP binding site [chemical binding]; other site 292563005790 substrate binding site [chemical binding]; other site 292563005791 activation loop (A-loop); other site 292563005792 Region in Clathrin and VPS; Region: Clathrin; pfam00637 292563005793 CO2 hydration protein (ChpXY); Region: ChpXY; pfam10216 292563005794 competence damage-inducible protein A; Provisional; Region: PRK00549 292563005795 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 292563005796 putative MPT binding site; other site 292563005797 Competence-damaged protein; Region: CinA; pfam02464 292563005798 SdiA-regulated; Region: SdiA-regulated; cd09971 292563005799 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 292563005800 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 292563005801 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 292563005802 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 292563005803 Ligand Binding Site [chemical binding]; other site 292563005804 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 292563005805 Mechanosensitive ion channel; Region: MS_channel; pfam00924 292563005806 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 292563005807 Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354 292563005808 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 292563005809 Protein of unknown function, DUF608; Region: DUF608; pfam04685 292563005810 Restriction endonuclease; Region: Mrr_cat; pfam04471 292563005811 Helix-turn-helix domain; Region: HTH_17; cl17695 292563005812 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 292563005813 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 292563005814 dinuclear metal binding motif [ion binding]; other site 292563005815 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 292563005816 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 292563005817 active site 292563005818 metal binding site [ion binding]; metal-binding site 292563005819 DNA binding site [nucleotide binding] 292563005820 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 292563005821 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 292563005822 Walker A motif; other site 292563005823 ATP binding site [chemical binding]; other site 292563005824 Walker B motif; other site 292563005825 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292563005826 S-adenosylmethionine binding site [chemical binding]; other site 292563005827 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 292563005828 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 292563005829 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 292563005830 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 292563005831 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 292563005832 hinge; other site 292563005833 active site 292563005834 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 292563005835 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 292563005836 active site 292563005837 metal binding site [ion binding]; metal-binding site 292563005838 hexamer interface [polypeptide binding]; other site 292563005839 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 292563005840 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 292563005841 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 292563005842 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 292563005843 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05945 292563005844 L-aspartate oxidase; Provisional; Region: PRK06175 292563005845 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 292563005846 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 292563005847 aromatic arch; other site 292563005848 DCoH dimer interaction site [polypeptide binding]; other site 292563005849 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 292563005850 DCoH tetramer interaction site [polypeptide binding]; other site 292563005851 substrate binding site [chemical binding]; other site 292563005852 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 292563005853 Probable transposase; Region: OrfB_IS605; pfam01385 292563005854 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 292563005855 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 292563005856 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 292563005857 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 292563005858 PRC-barrel domain; Region: PRC; pfam05239 292563005859 ketol-acid reductoisomerase; Provisional; Region: PRK05479 292563005860 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 292563005861 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 292563005862 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 292563005863 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 292563005864 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 292563005865 P loop; other site 292563005866 GTP binding site [chemical binding]; other site 292563005867 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 292563005868 active site 292563005869 8-oxo-dGMP binding site [chemical binding]; other site 292563005870 nudix motif; other site 292563005871 metal binding site [ion binding]; metal-binding site 292563005872 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 292563005873 Probable transposase; Region: OrfB_IS605; pfam01385 292563005874 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 292563005875 Uncharacterized conserved protein [Function unknown]; Region: COG2968 292563005876 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 292563005877 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 292563005878 putative active site pocket [active] 292563005879 dimerization interface [polypeptide binding]; other site 292563005880 putative catalytic residue [active] 292563005881 FOG: CBS domain [General function prediction only]; Region: COG0517 292563005882 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 292563005883 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292563005884 PAS fold; Region: PAS_3; pfam08447 292563005885 putative active site [active] 292563005886 heme pocket [chemical binding]; other site 292563005887 PAS domain S-box; Region: sensory_box; TIGR00229 292563005888 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292563005889 putative active site [active] 292563005890 heme pocket [chemical binding]; other site 292563005891 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292563005892 PAS fold; Region: PAS_3; pfam08447 292563005893 putative active site [active] 292563005894 heme pocket [chemical binding]; other site 292563005895 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 292563005896 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292563005897 dimer interface [polypeptide binding]; other site 292563005898 phosphorylation site [posttranslational modification] 292563005899 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292563005900 ATP binding site [chemical binding]; other site 292563005901 Mg2+ binding site [ion binding]; other site 292563005902 G-X-G motif; other site 292563005903 Response regulator receiver domain; Region: Response_reg; pfam00072 292563005904 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563005905 active site 292563005906 phosphorylation site [posttranslational modification] 292563005907 intermolecular recognition site; other site 292563005908 dimerization interface [polypeptide binding]; other site 292563005909 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 292563005910 active site lid residues [active] 292563005911 substrate binding pocket [chemical binding]; other site 292563005912 catalytic residues [active] 292563005913 substrate-Mg2+ binding site; other site 292563005914 aspartate-rich region 1; other site 292563005915 aspartate-rich region 2; other site 292563005916 phytoene desaturase; Region: phytoene_desat; TIGR02731 292563005917 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 292563005918 integral membrane protein MviN; Region: mviN; TIGR01695 292563005919 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 292563005920 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 292563005921 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 292563005922 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 292563005923 RNA polymerase sigma factor; Validated; Region: PRK05949 292563005924 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 292563005925 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 292563005926 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 292563005927 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 292563005928 DNA binding residues [nucleotide binding] 292563005929 Double zinc ribbon; Region: DZR; pfam12773 292563005930 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 292563005931 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 292563005932 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 292563005933 phosphopeptide binding site; other site 292563005934 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 292563005935 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 292563005936 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 292563005937 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 292563005938 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 292563005939 RNase_H superfamily; Region: RNase_H_2; pfam13482 292563005940 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 292563005941 dimer interface [polypeptide binding]; other site 292563005942 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 292563005943 putative radical transfer pathway; other site 292563005944 diiron center [ion binding]; other site 292563005945 tyrosyl radical; other site 292563005946 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 292563005947 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 292563005948 ABC-ATPase subunit interface; other site 292563005949 dimer interface [polypeptide binding]; other site 292563005950 putative PBP binding regions; other site 292563005951 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 292563005952 conserved hypothetical protein; Region: TIGR03492 292563005953 gamma-glutamyl kinase; Provisional; Region: PRK05429 292563005954 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 292563005955 nucleotide binding site [chemical binding]; other site 292563005956 homotetrameric interface [polypeptide binding]; other site 292563005957 putative phosphate binding site [ion binding]; other site 292563005958 putative allosteric binding site; other site 292563005959 PUA domain; Region: PUA; pfam01472 292563005960 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 292563005961 dimerization interface [polypeptide binding]; other site 292563005962 putative DNA binding site [nucleotide binding]; other site 292563005963 putative Zn2+ binding site [ion binding]; other site 292563005964 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 292563005965 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 292563005966 putative active site [active] 292563005967 catalytic triad [active] 292563005968 putative dimer interface [polypeptide binding]; other site 292563005969 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 292563005970 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 292563005971 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 292563005972 putative metal binding site; other site 292563005973 NADH dehydrogenase subunit 1; Region: ndhA; CHL00032 292563005974 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 292563005975 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 292563005976 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 292563005977 Coenzyme A binding pocket [chemical binding]; other site 292563005978 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 292563005979 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 292563005980 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 292563005981 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 292563005982 active site 292563005983 substrate binding site [chemical binding]; other site 292563005984 cosubstrate binding site; other site 292563005985 catalytic site [active] 292563005986 Protein of unknown function (DUF565); Region: DUF565; pfam04483 292563005987 H+ Antiporter protein; Region: 2A0121; TIGR00900 292563005988 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 292563005989 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 292563005990 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 292563005991 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 292563005992 Walker A/P-loop; other site 292563005993 ATP binding site [chemical binding]; other site 292563005994 Q-loop/lid; other site 292563005995 ABC transporter signature motif; other site 292563005996 Walker B; other site 292563005997 D-loop; other site 292563005998 H-loop/switch region; other site 292563005999 TOBE domain; Region: TOBE_2; pfam08402 292563006000 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 292563006001 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 292563006002 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 292563006003 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 292563006004 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 292563006005 putative active site [active] 292563006006 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 292563006007 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 292563006008 Walker A/P-loop; other site 292563006009 ATP binding site [chemical binding]; other site 292563006010 Q-loop/lid; other site 292563006011 ABC transporter signature motif; other site 292563006012 Walker B; other site 292563006013 D-loop; other site 292563006014 H-loop/switch region; other site 292563006015 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563006016 TPR motif; other site 292563006017 binding surface 292563006018 photosystem I reaction center subunit X; Reviewed; Region: PRK13214 292563006019 Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539 292563006020 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 292563006021 RNA binding site [nucleotide binding]; other site 292563006022 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 292563006023 RNA binding site [nucleotide binding]; other site 292563006024 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 292563006025 RNA binding site [nucleotide binding]; other site 292563006026 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 292563006027 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 292563006028 putative dimer interface [polypeptide binding]; other site 292563006029 putative anticodon binding site; other site 292563006030 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 292563006031 homodimer interface [polypeptide binding]; other site 292563006032 motif 1; other site 292563006033 motif 2; other site 292563006034 active site 292563006035 motif 3; other site 292563006036 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 292563006037 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 292563006038 Probable Catalytic site; other site 292563006039 agmatinase; Region: agmatinase; TIGR01230 292563006040 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 292563006041 putative active site [active] 292563006042 Mn binding site [ion binding]; other site 292563006043 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 292563006044 tetramer (dimer of dimers) interface [polypeptide binding]; other site 292563006045 active site 292563006046 dimer interface [polypeptide binding]; other site 292563006047 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 292563006048 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 292563006049 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 292563006050 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 292563006051 ligand binding site [chemical binding]; other site 292563006052 NAD binding site [chemical binding]; other site 292563006053 dimerization interface [polypeptide binding]; other site 292563006054 catalytic site [active] 292563006055 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 292563006056 putative L-serine binding site [chemical binding]; other site 292563006057 CHAD domain; Region: CHAD; cl10506 292563006058 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292563006059 S-adenosylmethionine binding site [chemical binding]; other site 292563006060 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 292563006061 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 292563006062 dimer interface [polypeptide binding]; other site 292563006063 tetramer interface [polypeptide binding]; other site 292563006064 PYR/PP interface [polypeptide binding]; other site 292563006065 TPP binding site [chemical binding]; other site 292563006066 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 292563006067 TPP-binding site; other site 292563006068 macrophage migration inhibition factor-like protein; Provisional; Region: PTZ00397 292563006069 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 292563006070 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 292563006071 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 292563006072 active site 292563006073 catalytic tetrad [active] 292563006074 HEAT repeats; Region: HEAT_2; pfam13646 292563006075 HEAT repeats; Region: HEAT_2; pfam13646 292563006076 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 292563006077 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 292563006078 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 292563006079 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 292563006080 GatB domain; Region: GatB_Yqey; smart00845 292563006081 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 292563006082 Predicted permeases [General function prediction only]; Region: COG0795 292563006083 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 292563006084 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 292563006085 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 292563006086 Mg2+ binding site [ion binding]; other site 292563006087 G-X-G motif; other site 292563006088 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 292563006089 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 292563006090 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 292563006091 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 292563006092 dimer interface [polypeptide binding]; other site 292563006093 motif 1; other site 292563006094 active site 292563006095 motif 2; other site 292563006096 motif 3; other site 292563006097 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 292563006098 anticodon binding site; other site 292563006099 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 292563006100 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 292563006101 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 292563006102 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 292563006103 catalytic loop [active] 292563006104 iron binding site [ion binding]; other site 292563006105 Staphylococcal nuclease homologues; Region: SNc; smart00318 292563006106 Catalytic site; other site 292563006107 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 292563006108 Repair protein; Region: Repair_PSII; pfam04536 292563006109 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 292563006110 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 292563006111 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 292563006112 Walker A/P-loop; other site 292563006113 ATP binding site [chemical binding]; other site 292563006114 Q-loop/lid; other site 292563006115 ABC transporter signature motif; other site 292563006116 Walker B; other site 292563006117 D-loop; other site 292563006118 H-loop/switch region; other site 292563006119 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 292563006120 putative DNA binding site [nucleotide binding]; other site 292563006121 dimerization interface [polypeptide binding]; other site 292563006122 putative Zn2+ binding site [ion binding]; other site 292563006123 CP12 domain; Region: CP12; pfam02672 292563006124 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 292563006125 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 292563006126 HEAT repeats; Region: HEAT_2; pfam13646 292563006127 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 292563006128 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 292563006129 homodecamer interface [polypeptide binding]; other site 292563006130 GTP cyclohydrolase I; Provisional; Region: PLN03044 292563006131 active site 292563006132 putative catalytic site residues [active] 292563006133 zinc binding site [ion binding]; other site 292563006134 GTP-CH-I/GFRP interaction surface; other site 292563006135 short chain dehydrogenase; Provisional; Region: PRK07454 292563006136 classical (c) SDRs; Region: SDR_c; cd05233 292563006137 NAD(P) binding site [chemical binding]; other site 292563006138 active site 292563006139 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 292563006140 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 292563006141 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 292563006142 lipoprotein signal peptidase; Provisional; Region: PRK14787 292563006143 BioY family; Region: BioY; pfam02632 292563006144 biotin synthase; Region: bioB; TIGR00433 292563006145 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 292563006146 FeS/SAM binding site; other site 292563006147 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 292563006148 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 292563006149 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 292563006150 hinge; other site 292563006151 active site 292563006152 Response regulator receiver domain; Region: Response_reg; pfam00072 292563006153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563006154 active site 292563006155 phosphorylation site [posttranslational modification] 292563006156 intermolecular recognition site; other site 292563006157 dimerization interface [polypeptide binding]; other site 292563006158 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 292563006159 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563006160 binding surface 292563006161 Tetratricopeptide repeat; Region: TPR_16; pfam13432 292563006162 TPR motif; other site 292563006163 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 292563006164 dimerization interface [polypeptide binding]; other site 292563006165 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 292563006166 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 292563006167 dimer interface [polypeptide binding]; other site 292563006168 putative CheW interface [polypeptide binding]; other site 292563006169 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 292563006170 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 292563006171 HSP70 interaction site [polypeptide binding]; other site 292563006172 Protein of unknown function (DUF3143); Region: DUF3143; pfam11341 292563006173 Protein of unknown function (DUF3067); Region: DUF3067; pfam11267 292563006174 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 292563006175 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 292563006176 Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471 292563006177 cytochrome b subunit interaction site [polypeptide binding]; other site 292563006178 [2Fe-2S] cluster binding site [ion binding]; other site 292563006179 cytochrome f; Region: petA; CHL00037 292563006180 apocytochrome f; Reviewed; Region: PRK02693 292563006181 chain length determinant protein tyrosine kinase EpsG; Region: EpsG; TIGR03029 292563006182 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 292563006183 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 292563006184 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cl01268 292563006185 Domain of unknown function (DUF4033); Region: DUF4033; pfam13225 292563006186 urease subunit alpha; Reviewed; Region: ureC; PRK13207 292563006187 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 292563006188 subunit interactions [polypeptide binding]; other site 292563006189 active site 292563006190 flap region; other site 292563006191 PIN domain; Region: PIN; pfam01850 292563006192 putative active site [active] 292563006193 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 292563006194 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 292563006195 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 292563006196 catalytic residue [active] 292563006197 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 292563006198 D-xylulose kinase; Region: XylB; TIGR01312 292563006199 nucleotide binding site [chemical binding]; other site 292563006200 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 292563006201 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 292563006202 putative active site [active] 292563006203 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 292563006204 active site 292563006205 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 292563006206 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 292563006207 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 292563006208 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 292563006209 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 292563006210 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 292563006211 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 292563006212 active site 292563006213 motif I; other site 292563006214 motif II; other site 292563006215 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 292563006216 photosystem I P700 chlorophyll a apoprotein A1; Region: psaA; CHL00056 292563006217 photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199 292563006218 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 292563006219 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 292563006220 cofactor binding site; other site 292563006221 DNA binding site [nucleotide binding] 292563006222 substrate interaction site [chemical binding]; other site 292563006223 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 292563006224 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 292563006225 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 292563006226 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 292563006227 trimer interface [polypeptide binding]; other site 292563006228 active site 292563006229 UDP-GlcNAc binding site [chemical binding]; other site 292563006230 lipid binding site [chemical binding]; lipid-binding site 292563006231 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 292563006232 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 292563006233 putative metal binding site [ion binding]; other site 292563006234 geranylgeranyl reductase; Region: ChlP; TIGR02028 292563006235 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 292563006236 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 292563006237 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 292563006238 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 292563006239 Methyltransferase domain; Region: Methyltransf_24; pfam13578 292563006240 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 292563006241 active site 292563006242 Pleckstrin homology-like domain; Region: PH-like; cl17171 292563006243 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 292563006244 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 292563006245 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 292563006246 Cache domain; Region: Cache_1; pfam02743 292563006247 HAMP domain; Region: HAMP; pfam00672 292563006248 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 292563006249 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292563006250 dimer interface [polypeptide binding]; other site 292563006251 phosphorylation site [posttranslational modification] 292563006252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292563006253 ATP binding site [chemical binding]; other site 292563006254 Mg2+ binding site [ion binding]; other site 292563006255 G-X-G motif; other site 292563006256 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 292563006257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563006258 active site 292563006259 phosphorylation site [posttranslational modification] 292563006260 intermolecular recognition site; other site 292563006261 dimerization interface [polypeptide binding]; other site 292563006262 Response regulator receiver domain; Region: Response_reg; pfam00072 292563006263 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563006264 active site 292563006265 phosphorylation site [posttranslational modification] 292563006266 intermolecular recognition site; other site 292563006267 dimerization interface [polypeptide binding]; other site 292563006268 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 292563006269 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 292563006270 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 292563006271 Zn2+ binding site [ion binding]; other site 292563006272 Mg2+ binding site [ion binding]; other site 292563006273 putative glycosyl transferase; Provisional; Region: PRK10307 292563006274 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 292563006275 recombinase A; Provisional; Region: recA; PRK09354 292563006276 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 292563006277 hexamer interface [polypeptide binding]; other site 292563006278 Walker A motif; other site 292563006279 ATP binding site [chemical binding]; other site 292563006280 Walker B motif; other site 292563006281 5'-methylthioadenosine phosphorylase; Provisional; Region: PRK07432 292563006282 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 292563006283 active site 292563006284 hypothetical protein; Provisional; Region: PRK07377 292563006285 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 292563006286 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 292563006287 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 292563006288 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 292563006289 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 292563006290 active site 292563006291 SAM binding site [chemical binding]; other site 292563006292 homodimer interface [polypeptide binding]; other site 292563006293 peptide chain release factor 1; Validated; Region: prfA; PRK00591 292563006294 This domain is found in peptide chain release factors; Region: PCRF; smart00937 292563006295 RF-1 domain; Region: RF-1; pfam00472 292563006296 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 292563006297 HlyD family secretion protein; Region: HlyD_3; pfam13437 292563006298 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 292563006299 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 292563006300 Walker A/P-loop; other site 292563006301 ATP binding site [chemical binding]; other site 292563006302 Q-loop/lid; other site 292563006303 ABC transporter signature motif; other site 292563006304 Walker B; other site 292563006305 D-loop; other site 292563006306 H-loop/switch region; other site 292563006307 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 292563006308 Walker A/P-loop; other site 292563006309 ATP binding site [chemical binding]; other site 292563006310 Q-loop/lid; other site 292563006311 ABC transporter signature motif; other site 292563006312 Walker B; other site 292563006313 D-loop; other site 292563006314 H-loop/switch region; other site 292563006315 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 292563006316 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 292563006317 Switch II region; other site 292563006318 G4 box; other site 292563006319 Domain of unknown function (DUF697); Region: DUF697; pfam05128 292563006320 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 292563006321 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 292563006322 nudix motif; other site 292563006323 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 292563006324 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 292563006325 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 292563006326 FeS/SAM binding site; other site 292563006327 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 292563006328 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 292563006329 mce related protein; Region: MCE; pfam02470 292563006330 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 292563006331 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 292563006332 Walker A/P-loop; other site 292563006333 ATP binding site [chemical binding]; other site 292563006334 Q-loop/lid; other site 292563006335 ABC transporter signature motif; other site 292563006336 Walker B; other site 292563006337 D-loop; other site 292563006338 H-loop/switch region; other site 292563006339 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 292563006340 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 292563006341 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 292563006342 Probable transposase; Region: OrfB_IS605; pfam01385 292563006343 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 292563006344 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 292563006345 C-terminal peptidase (prc); Region: prc; TIGR00225 292563006346 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 292563006347 protein binding site [polypeptide binding]; other site 292563006348 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 292563006349 Catalytic dyad [active] 292563006350 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 292563006351 active site 292563006352 dimer interface [polypeptide binding]; other site 292563006353 PIN domain; Region: PIN_3; cl17397 292563006354 L-asparaginase II; Region: Asparaginase_II; pfam06089 292563006355 Protein of unknown function (DUF1230); Region: DUF1230; pfam06799 292563006356 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 292563006357 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 292563006358 putative NAD(P) binding site [chemical binding]; other site 292563006359 active site 292563006360 exonuclease SbcC; Region: sbcc; TIGR00618 292563006361 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292563006362 Walker A/P-loop; other site 292563006363 ATP binding site [chemical binding]; other site 292563006364 Q-loop/lid; other site 292563006365 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 292563006366 ABC transporter signature motif; other site 292563006367 Walker B; other site 292563006368 D-loop; other site 292563006369 H-loop/switch region; other site 292563006370 CHASE domain; Region: CHASE; cl01369 292563006371 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292563006372 dimer interface [polypeptide binding]; other site 292563006373 phosphorylation site [posttranslational modification] 292563006374 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292563006375 ATP binding site [chemical binding]; other site 292563006376 Mg2+ binding site [ion binding]; other site 292563006377 G-X-G motif; other site 292563006378 Response regulator receiver domain; Region: Response_reg; pfam00072 292563006379 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563006380 active site 292563006381 phosphorylation site [posttranslational modification] 292563006382 intermolecular recognition site; other site 292563006383 dimerization interface [polypeptide binding]; other site 292563006384 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 292563006385 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 292563006386 putative phosphoketolase; Provisional; Region: PRK05261 292563006387 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 292563006388 TPP-binding site; other site 292563006389 XFP C-terminal domain; Region: XFP_C; pfam09363 292563006390 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 292563006391 UbiA prenyltransferase family; Region: UbiA; pfam01040 292563006392 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 292563006393 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 292563006394 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 292563006395 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 292563006396 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 292563006397 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 292563006398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 292563006399 dimer interface [polypeptide binding]; other site 292563006400 conserved gate region; other site 292563006401 putative PBP binding loops; other site 292563006402 ABC-ATPase subunit interface; other site 292563006403 S-layer homology domain; Region: SLH; pfam00395 292563006404 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 292563006405 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 292563006406 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563006407 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563006408 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 292563006409 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 292563006410 Ligand binding site; other site 292563006411 Putative Catalytic site; other site 292563006412 DXD motif; other site 292563006413 Predicted membrane protein [Function unknown]; Region: COG2246 292563006414 GtrA-like protein; Region: GtrA; pfam04138 292563006415 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 292563006416 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 292563006417 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 292563006418 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 292563006419 PhoU domain; Region: PhoU; pfam01895 292563006420 PhoU domain; Region: PhoU; pfam01895 292563006421 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 292563006422 S17 interaction site [polypeptide binding]; other site 292563006423 S8 interaction site; other site 292563006424 16S rRNA interaction site [nucleotide binding]; other site 292563006425 streptomycin interaction site [chemical binding]; other site 292563006426 23S rRNA interaction site [nucleotide binding]; other site 292563006427 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 292563006428 30S ribosomal protein S7; Validated; Region: PRK05302 292563006429 elongation factor G; Reviewed; Region: PRK00007 292563006430 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 292563006431 G1 box; other site 292563006432 putative GEF interaction site [polypeptide binding]; other site 292563006433 GTP/Mg2+ binding site [chemical binding]; other site 292563006434 Switch I region; other site 292563006435 G2 box; other site 292563006436 G3 box; other site 292563006437 Switch II region; other site 292563006438 G4 box; other site 292563006439 G5 box; other site 292563006440 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 292563006441 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 292563006442 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 292563006443 elongation factor Tu; Region: tufA; CHL00071 292563006444 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 292563006445 G1 box; other site 292563006446 GEF interaction site [polypeptide binding]; other site 292563006447 GTP/Mg2+ binding site [chemical binding]; other site 292563006448 Switch I region; other site 292563006449 G2 box; other site 292563006450 G3 box; other site 292563006451 Switch II region; other site 292563006452 G4 box; other site 292563006453 G5 box; other site 292563006454 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 292563006455 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 292563006456 Antibiotic Binding Site [chemical binding]; other site 292563006457 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 292563006458 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 292563006459 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 292563006460 23S rRNA binding site [nucleotide binding]; other site 292563006461 L21 binding site [polypeptide binding]; other site 292563006462 L13 binding site [polypeptide binding]; other site 292563006463 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 292563006464 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 292563006465 16S rRNA methyltransferase B; Provisional; Region: PRK14901 292563006466 NusB family; Region: NusB; pfam01029 292563006467 putative RNA binding site [nucleotide binding]; other site 292563006468 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292563006469 S-adenosylmethionine binding site [chemical binding]; other site 292563006470 tellurium resistance terB-like protein; Region: terB_like; cd07177 292563006471 metal binding site [ion binding]; metal-binding site 292563006472 Myxococcus xanthus DevT and related proteins, metallophosphatase domain; Region: MPP_DevT; cd07397 292563006473 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 292563006474 putative active site [active] 292563006475 putative metal binding site [ion binding]; other site 292563006476 Tetratricopeptide repeat; Region: TPR_12; pfam13424 292563006477 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563006478 binding surface 292563006479 TPR motif; other site 292563006480 TPR repeat; Region: TPR_11; pfam13414 292563006481 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 292563006482 Protein of unknown function, DUF482; Region: DUF482; pfam04339 292563006483 aspartate aminotransferase; Provisional; Region: PRK05764 292563006484 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 292563006485 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292563006486 homodimer interface [polypeptide binding]; other site 292563006487 catalytic residue [active] 292563006488 Protein of unknown function (DUF3252); Region: DUF3252; pfam11623 292563006489 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 292563006490 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 292563006491 dimerization interface [polypeptide binding]; other site 292563006492 FAD binding pocket [chemical binding]; other site 292563006493 FAD binding motif [chemical binding]; other site 292563006494 catalytic residues [active] 292563006495 NAD binding pocket [chemical binding]; other site 292563006496 phosphate binding motif [ion binding]; other site 292563006497 beta-alpha-beta structure motif; other site 292563006498 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 292563006499 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 292563006500 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 292563006501 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 292563006502 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 292563006503 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 292563006504 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 292563006505 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 292563006506 Late competence development protein ComFB; Region: ComFB; pfam10719 292563006507 multifunctional aminopeptidase A; Provisional; Region: PRK00913 292563006508 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 292563006509 interface (dimer of trimers) [polypeptide binding]; other site 292563006510 Substrate-binding/catalytic site; other site 292563006511 Zn-binding sites [ion binding]; other site 292563006512 Methyltransferase domain; Region: Methyltransf_23; pfam13489 292563006513 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292563006514 S-adenosylmethionine binding site [chemical binding]; other site 292563006515 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 292563006516 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 292563006517 active site 292563006518 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 292563006519 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 292563006520 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 292563006521 active site 292563006522 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 292563006523 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 292563006524 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 292563006525 Domain of unknown function DUF29; Region: DUF29; pfam01724 292563006526 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 292563006527 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 292563006528 YcfA-like protein; Region: YcfA; cl00752 292563006529 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 292563006530 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 292563006531 YcfA-like protein; Region: YcfA; pfam07927 292563006532 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 292563006533 L-lactate permease; Region: Lactate_perm; cl00701 292563006534 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 292563006535 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 292563006536 NAD binding site [chemical binding]; other site 292563006537 substrate binding site [chemical binding]; other site 292563006538 homodimer interface [polypeptide binding]; other site 292563006539 active site 292563006540 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 292563006541 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 292563006542 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 292563006543 NADP binding site [chemical binding]; other site 292563006544 active site 292563006545 putative substrate binding site [chemical binding]; other site 292563006546 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 292563006547 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 292563006548 substrate binding site; other site 292563006549 tetramer interface; other site 292563006550 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 292563006551 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292563006552 Walker A/P-loop; other site 292563006553 ATP binding site [chemical binding]; other site 292563006554 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 292563006555 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292563006556 S-adenosylmethionine binding site [chemical binding]; other site 292563006557 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 292563006558 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 292563006559 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 292563006560 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292563006561 putative active site [active] 292563006562 heme pocket [chemical binding]; other site 292563006563 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292563006564 PAS fold; Region: PAS_3; pfam08447 292563006565 putative active site [active] 292563006566 heme pocket [chemical binding]; other site 292563006567 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292563006568 PAS fold; Region: PAS_3; pfam08447 292563006569 putative active site [active] 292563006570 heme pocket [chemical binding]; other site 292563006571 GAF domain; Region: GAF; pfam01590 292563006572 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 292563006573 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292563006574 dimer interface [polypeptide binding]; other site 292563006575 phosphorylation site [posttranslational modification] 292563006576 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292563006577 ATP binding site [chemical binding]; other site 292563006578 Mg2+ binding site [ion binding]; other site 292563006579 G-X-G motif; other site 292563006580 Response regulator receiver domain; Region: Response_reg; pfam00072 292563006581 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563006582 active site 292563006583 phosphorylation site [posttranslational modification] 292563006584 intermolecular recognition site; other site 292563006585 dimerization interface [polypeptide binding]; other site 292563006586 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 292563006587 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563006588 active site 292563006589 phosphorylation site [posttranslational modification] 292563006590 intermolecular recognition site; other site 292563006591 dimerization interface [polypeptide binding]; other site 292563006592 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 292563006593 dimer interface [polypeptide binding]; other site 292563006594 [2Fe-2S] cluster binding site [ion binding]; other site 292563006595 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 292563006596 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 292563006597 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 292563006598 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 292563006599 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292563006600 dimer interface [polypeptide binding]; other site 292563006601 phosphorylation site [posttranslational modification] 292563006602 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292563006603 ATP binding site [chemical binding]; other site 292563006604 Mg2+ binding site [ion binding]; other site 292563006605 G-X-G motif; other site 292563006606 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 292563006607 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563006608 active site 292563006609 phosphorylation site [posttranslational modification] 292563006610 intermolecular recognition site; other site 292563006611 dimerization interface [polypeptide binding]; other site 292563006612 Response regulator receiver domain; Region: Response_reg; pfam00072 292563006613 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563006614 active site 292563006615 phosphorylation site [posttranslational modification] 292563006616 intermolecular recognition site; other site 292563006617 dimerization interface [polypeptide binding]; other site 292563006618 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 292563006619 Amidinotransferase; Region: Amidinotransf; cl12043 292563006620 Uncharacterized conserved protein [Function unknown]; Region: COG1915 292563006621 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144 292563006622 homodimer interface [polypeptide binding]; other site 292563006623 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 292563006624 cobalt transport protein CbiM; Validated; Region: PRK06265 292563006625 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 292563006626 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 292563006627 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 292563006628 catalytic triad [active] 292563006629 Domain of unknown function (DUF305); Region: DUF305; pfam03713 292563006630 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 292563006631 aspartate kinase; Provisional; Region: PRK07431 292563006632 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 292563006633 putative catalytic residues [active] 292563006634 putative nucleotide binding site [chemical binding]; other site 292563006635 putative aspartate binding site [chemical binding]; other site 292563006636 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 292563006637 putative allosteric regulatory site; other site 292563006638 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 292563006639 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 292563006640 putative allosteric regulatory site; other site 292563006641 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 292563006642 putative allosteric regulatory residue; other site 292563006643 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304 292563006644 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 292563006645 HSP70 interaction site [polypeptide binding]; other site 292563006646 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563006647 binding surface 292563006648 TPR motif; other site 292563006649 TPR repeat; Region: TPR_11; pfam13414 292563006650 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 292563006651 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 292563006652 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 292563006653 acyl-activating enzyme (AAE) consensus motif; other site 292563006654 putative AMP binding site [chemical binding]; other site 292563006655 putative active site [active] 292563006656 putative CoA binding site [chemical binding]; other site 292563006657 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 292563006658 active site 292563006659 catalytic residues [active] 292563006660 metal binding site [ion binding]; metal-binding site 292563006661 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 292563006662 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 292563006663 Response regulator receiver domain; Region: Response_reg; pfam00072 292563006664 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563006665 active site 292563006666 phosphorylation site [posttranslational modification] 292563006667 intermolecular recognition site; other site 292563006668 dimerization interface [polypeptide binding]; other site 292563006669 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 292563006670 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292563006671 dimer interface [polypeptide binding]; other site 292563006672 phosphorylation site [posttranslational modification] 292563006673 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292563006674 ATP binding site [chemical binding]; other site 292563006675 Mg2+ binding site [ion binding]; other site 292563006676 G-X-G motif; other site 292563006677 Domain of unknown function DUF59; Region: DUF59; pfam01883 292563006678 antiporter inner membrane protein; Provisional; Region: PRK11670 292563006679 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 292563006680 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 292563006681 putative active site [active] 292563006682 Tetratricopeptide repeat; Region: TPR_12; pfam13424 292563006683 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563006684 binding surface 292563006685 TPR motif; other site 292563006686 Tetratricopeptide repeat; Region: TPR_12; pfam13424 292563006687 Tetratricopeptide repeat; Region: TPR_12; pfam13424 292563006688 Tetratricopeptide repeat; Region: TPR_10; pfam13374 292563006689 Tetratricopeptide repeat; Region: TPR_12; pfam13424 292563006690 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563006691 binding surface 292563006692 TPR motif; other site 292563006693 Tetratricopeptide repeat; Region: TPR_12; pfam13424 292563006694 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563006695 binding surface 292563006696 TPR motif; other site 292563006697 Tetratricopeptide repeat; Region: TPR_12; pfam13424 292563006698 CHAT domain; Region: CHAT; pfam12770 292563006699 glycine dehydrogenase; Provisional; Region: PRK05367 292563006700 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 292563006701 tetramer interface [polypeptide binding]; other site 292563006702 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292563006703 catalytic residue [active] 292563006704 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 292563006705 tetramer interface [polypeptide binding]; other site 292563006706 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292563006707 catalytic residue [active] 292563006708 PemK-like protein; Region: PemK; pfam02452 292563006709 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 292563006710 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 292563006711 motif 1; other site 292563006712 active site 292563006713 motif 2; other site 292563006714 motif 3; other site 292563006715 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 292563006716 DHHA1 domain; Region: DHHA1; pfam02272 292563006717 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 292563006718 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 292563006719 active site 292563006720 substrate binding site [chemical binding]; other site 292563006721 metal binding site [ion binding]; metal-binding site 292563006722 phosphoribulokinase; Provisional; Region: PRK07429 292563006723 Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026 292563006724 active site 292563006725 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 292563006726 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 292563006727 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 292563006728 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 292563006729 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 292563006730 CoA binding domain; Region: CoA_binding; cl17356 292563006731 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 292563006732 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 292563006733 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 292563006734 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 292563006735 active site 292563006736 dimer interface [polypeptide binding]; other site 292563006737 motif 1; other site 292563006738 motif 2; other site 292563006739 motif 3; other site 292563006740 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 292563006741 anticodon binding site; other site 292563006742 prephenate dehydratase; Provisional; Region: PRK11898 292563006743 Prephenate dehydratase; Region: PDT; pfam00800 292563006744 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 292563006745 putative L-Phe binding site [chemical binding]; other site 292563006746 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 292563006747 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563006748 active site 292563006749 phosphorylation site [posttranslational modification] 292563006750 intermolecular recognition site; other site 292563006751 dimerization interface [polypeptide binding]; other site 292563006752 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 292563006753 DNA binding residues [nucleotide binding] 292563006754 dimerization interface [polypeptide binding]; other site 292563006755 Protein of unknown function (DUF2854); Region: DUF2854; pfam11016 292563006756 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 292563006757 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 292563006758 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 292563006759 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 292563006760 Probable transposase; Region: OrfB_IS605; pfam01385 292563006761 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 292563006762 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 292563006763 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 292563006764 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 292563006765 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 292563006766 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 292563006767 GAF domain; Region: GAF; pfam01590 292563006768 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 292563006769 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292563006770 dimer interface [polypeptide binding]; other site 292563006771 phosphorylation site [posttranslational modification] 292563006772 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292563006773 ATP binding site [chemical binding]; other site 292563006774 Mg2+ binding site [ion binding]; other site 292563006775 G-X-G motif; other site 292563006776 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 292563006777 Ycf35; Provisional; Region: ycf35; CHL00193 292563006778 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 292563006779 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 292563006780 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 292563006781 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 292563006782 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 292563006783 Walker A/P-loop; other site 292563006784 ATP binding site [chemical binding]; other site 292563006785 Q-loop/lid; other site 292563006786 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 292563006787 ABC transporter signature motif; other site 292563006788 Walker B; other site 292563006789 D-loop; other site 292563006790 H-loop/switch region; other site 292563006791 Protein kinase domain; Region: Pkinase; pfam00069 292563006792 Catalytic domain of Protein Kinases; Region: PKc; cd00180 292563006793 active site 292563006794 ATP binding site [chemical binding]; other site 292563006795 substrate binding site [chemical binding]; other site 292563006796 activation loop (A-loop); other site 292563006797 AAA ATPase domain; Region: AAA_16; pfam13191 292563006798 Predicted ATPase [General function prediction only]; Region: COG3899 292563006799 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 292563006800 GAF domain; Region: GAF; pfam01590 292563006801 PAS domain; Region: PAS_9; pfam13426 292563006802 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 292563006803 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 292563006804 metal binding site [ion binding]; metal-binding site 292563006805 active site 292563006806 I-site; other site 292563006807 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 292563006808 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 292563006809 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 292563006810 DHH family; Region: DHH; pfam01368 292563006811 FOG: CBS domain [General function prediction only]; Region: COG0517 292563006812 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 292563006813 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 292563006814 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 292563006815 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 292563006816 active site 292563006817 NTP binding site [chemical binding]; other site 292563006818 metal binding triad [ion binding]; metal-binding site 292563006819 OstA-like protein; Region: OstA; cl00844 292563006820 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 292563006821 Protein of unknown function (DUF3769); Region: DUF3769; pfam12600 292563006822 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 292563006823 substrate binding site [chemical binding]; other site 292563006824 active site 292563006825 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 292563006826 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 292563006827 phosphate binding site [ion binding]; other site 292563006828 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 292563006829 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 292563006830 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292563006831 S-adenosylmethionine binding site [chemical binding]; other site 292563006832 prolyl-tRNA synthetase; Provisional; Region: PRK09194 292563006833 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 292563006834 dimer interface [polypeptide binding]; other site 292563006835 motif 1; other site 292563006836 active site 292563006837 motif 2; other site 292563006838 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 292563006839 putative deacylase active site [active] 292563006840 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 292563006841 active site 292563006842 motif 3; other site 292563006843 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 292563006844 anticodon binding site; other site 292563006845 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 292563006846 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 292563006847 active site 292563006848 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 292563006849 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 292563006850 substrate binding pocket [chemical binding]; other site 292563006851 chain length determination region; other site 292563006852 substrate-Mg2+ binding site; other site 292563006853 catalytic residues [active] 292563006854 aspartate-rich region 1; other site 292563006855 active site lid residues [active] 292563006856 aspartate-rich region 2; other site 292563006857 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 292563006858 ABC1 family; Region: ABC1; cl17513 292563006859 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 292563006860 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292563006861 dimer interface [polypeptide binding]; other site 292563006862 phosphorylation site [posttranslational modification] 292563006863 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292563006864 ATP binding site [chemical binding]; other site 292563006865 Mg2+ binding site [ion binding]; other site 292563006866 G-X-G motif; other site 292563006867 Domain of unknown function DUF20; Region: UPF0118; pfam01594 292563006868 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 292563006869 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 292563006870 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 292563006871 dimer interface [polypeptide binding]; other site 292563006872 conserved gate region; other site 292563006873 putative PBP binding loops; other site 292563006874 ABC-ATPase subunit interface; other site 292563006875 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 292563006876 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 292563006877 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 292563006878 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 292563006879 SLBB domain; Region: SLBB; pfam10531 292563006880 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 292563006881 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 292563006882 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 292563006883 Nucleotide binding site [chemical binding]; other site 292563006884 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 292563006885 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 292563006886 ribosomal protein L31; Validated; Region: rpl31; CHL00136 292563006887 ribosomal protein S9; Region: rps9; CHL00079 292563006888 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 292563006889 23S rRNA interface [nucleotide binding]; other site 292563006890 L3 interface [polypeptide binding]; other site 292563006891 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 292563006892 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 292563006893 dimerization interface 3.5A [polypeptide binding]; other site 292563006894 active site 292563006895 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 292563006896 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 292563006897 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 292563006898 alphaNTD homodimer interface [polypeptide binding]; other site 292563006899 alphaNTD - beta interaction site [polypeptide binding]; other site 292563006900 alphaNTD - beta' interaction site [polypeptide binding]; other site 292563006901 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 292563006902 30S ribosomal protein S11; Validated; Region: PRK05309 292563006903 ribosomal protein S13; Validated; Region: rps13; CHL00137 292563006904 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 292563006905 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 292563006906 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 292563006907 rRNA binding site [nucleotide binding]; other site 292563006908 predicted 30S ribosome binding site; other site 292563006909 adenylate kinase; Reviewed; Region: adk; PRK00279 292563006910 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 292563006911 AMP-binding site [chemical binding]; other site 292563006912 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 292563006913 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 292563006914 SecY translocase; Region: SecY; pfam00344 292563006915 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 292563006916 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 292563006917 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 292563006918 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 292563006919 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 292563006920 23S rRNA interface [nucleotide binding]; other site 292563006921 L21e interface [polypeptide binding]; other site 292563006922 5S rRNA interface [nucleotide binding]; other site 292563006923 L27 interface [polypeptide binding]; other site 292563006924 L5 interface [polypeptide binding]; other site 292563006925 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 292563006926 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 292563006927 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 292563006928 ribosomal protein S8; Region: rps8; CHL00042 292563006929 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 292563006930 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 292563006931 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 292563006932 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 292563006933 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 292563006934 RNA binding site [nucleotide binding]; other site 292563006935 ribosomal protein L14; Region: rpl14; CHL00057 292563006936 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 292563006937 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 292563006938 23S rRNA interface [nucleotide binding]; other site 292563006939 putative translocon interaction site; other site 292563006940 signal recognition particle (SRP54) interaction site; other site 292563006941 L23 interface [polypeptide binding]; other site 292563006942 trigger factor interaction site; other site 292563006943 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 292563006944 23S rRNA interface [nucleotide binding]; other site 292563006945 5S rRNA interface [nucleotide binding]; other site 292563006946 putative antibiotic binding site [chemical binding]; other site 292563006947 L25 interface [polypeptide binding]; other site 292563006948 L27 interface [polypeptide binding]; other site 292563006949 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 292563006950 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 292563006951 G-X-X-G motif; other site 292563006952 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 292563006953 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 292563006954 putative translocon binding site; other site 292563006955 protein-rRNA interface [nucleotide binding]; other site 292563006956 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 292563006957 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 292563006958 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 292563006959 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 292563006960 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 292563006961 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 292563006962 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 292563006963 Sec-independent translocase component C; Provisional; Region: tatC; CHL00182 292563006964 Catalytic domain of Protein Kinases; Region: PKc; cd00180 292563006965 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 292563006966 active site 292563006967 substrate binding site [chemical binding]; other site 292563006968 ATP binding site [chemical binding]; other site 292563006969 activation loop (A-loop); other site 292563006970 TPR repeat; Region: TPR_11; pfam13414 292563006971 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563006972 binding surface 292563006973 TPR motif; other site 292563006974 TPR repeat; Region: TPR_11; pfam13414 292563006975 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563006976 binding surface 292563006977 TPR motif; other site 292563006978 TPR repeat; Region: TPR_11; pfam13414 292563006979 TPR repeat; Region: TPR_11; pfam13414 292563006980 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563006981 binding surface 292563006982 TPR motif; other site 292563006983 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 292563006984 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 292563006985 phosphopeptide binding site; other site 292563006986 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 292563006987 phosphopeptide binding site; other site 292563006988 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 292563006989 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 292563006990 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 292563006991 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 292563006992 cofactor binding site; other site 292563006993 DNA binding site [nucleotide binding] 292563006994 substrate interaction site [chemical binding]; other site 292563006995 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 292563006996 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 292563006997 metal binding site [ion binding]; metal-binding site 292563006998 dimer interface [polypeptide binding]; other site 292563006999 GUN4-like; Region: GUN4; pfam05419 292563007000 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 292563007001 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 292563007002 active site 292563007003 nucleotide binding site [chemical binding]; other site 292563007004 HIGH motif; other site 292563007005 KMSKS motif; other site 292563007006 DnaJ domain; Region: DnaJ; pfam00226 292563007007 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 292563007008 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 292563007009 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 292563007010 DNA binding residues [nucleotide binding] 292563007011 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 292563007012 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 292563007013 substrate binding pocket [chemical binding]; other site 292563007014 membrane-bound complex binding site; other site 292563007015 hinge residues; other site 292563007016 enolase; Provisional; Region: eno; PRK00077 292563007017 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 292563007018 dimer interface [polypeptide binding]; other site 292563007019 metal binding site [ion binding]; metal-binding site 292563007020 substrate binding pocket [chemical binding]; other site 292563007021 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 292563007022 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 292563007023 Probable transposase; Region: OrfB_IS605; pfam01385 292563007024 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 292563007025 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 292563007026 ABC1 family; Region: ABC1; cl17513 292563007027 Membrane protein of unknown function; Region: DUF360; pfam04020 292563007028 EamA-like transporter family; Region: EamA; pfam00892 292563007029 CTP synthetase; Validated; Region: pyrG; PRK05380 292563007030 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 292563007031 Catalytic site [active] 292563007032 active site 292563007033 UTP binding site [chemical binding]; other site 292563007034 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 292563007035 active site 292563007036 putative oxyanion hole; other site 292563007037 catalytic triad [active] 292563007038 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371 292563007039 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 292563007040 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 292563007041 Major Facilitator Superfamily; Region: MFS_1; pfam07690 292563007042 putative substrate translocation pore; other site 292563007043 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 292563007044 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 292563007045 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 292563007046 ThiS interaction site; other site 292563007047 putative active site [active] 292563007048 tetramer interface [polypeptide binding]; other site 292563007049 FAD binding domain; Region: FAD_binding_4; pfam01565 292563007050 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 292563007051 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 292563007052 Pyruvate formate lyase 1; Region: PFL1; cd01678 292563007053 coenzyme A binding site [chemical binding]; other site 292563007054 active site 292563007055 catalytic residues [active] 292563007056 glycine loop; other site 292563007057 CsbD-like; Region: CsbD; cl17424 292563007058 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 292563007059 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 292563007060 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 292563007061 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 292563007062 photosystem II protein PsbQ; Region: PS_II_psbQ_bact; TIGR03042 292563007063 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 292563007064 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 292563007065 putative acyl-acceptor binding pocket; other site 292563007066 S-layer homology domain; Region: SLH; pfam00395 292563007067 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 292563007068 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 292563007069 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 292563007070 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 292563007071 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 292563007072 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 292563007073 B12 binding site [chemical binding]; other site 292563007074 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 292563007075 FeS/SAM binding site; other site 292563007076 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 292563007077 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 292563007078 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 292563007079 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 292563007080 dimer interface [polypeptide binding]; other site 292563007081 motif 1; other site 292563007082 active site 292563007083 motif 2; other site 292563007084 motif 3; other site 292563007085 Response regulator receiver domain; Region: Response_reg; pfam00072 292563007086 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563007087 active site 292563007088 phosphorylation site [posttranslational modification] 292563007089 intermolecular recognition site; other site 292563007090 dimerization interface [polypeptide binding]; other site 292563007091 DNA polymerase I; Provisional; Region: PRK05755 292563007092 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 292563007093 active site 292563007094 metal binding site 1 [ion binding]; metal-binding site 292563007095 putative 5' ssDNA interaction site; other site 292563007096 metal binding site 3; metal-binding site 292563007097 metal binding site 2 [ion binding]; metal-binding site 292563007098 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 292563007099 putative DNA binding site [nucleotide binding]; other site 292563007100 putative metal binding site [ion binding]; other site 292563007101 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 292563007102 active site 292563007103 catalytic site [active] 292563007104 substrate binding site [chemical binding]; other site 292563007105 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 292563007106 active site 292563007107 DNA binding site [nucleotide binding] 292563007108 catalytic site [active] 292563007109 deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556 292563007110 DNA photolyase; Region: DNA_photolyase; pfam00875 292563007111 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 292563007112 nucleotide binding site/active site [active] 292563007113 HIT family signature motif; other site 292563007114 catalytic residue [active] 292563007115 pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144 292563007116 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 292563007117 alpha subunit interface [polypeptide binding]; other site 292563007118 TPP binding site [chemical binding]; other site 292563007119 heterodimer interface [polypeptide binding]; other site 292563007120 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 292563007121 protein-export membrane protein SecD; Region: secD; TIGR01129 292563007122 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 292563007123 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 292563007124 Protein export membrane protein; Region: SecD_SecF; pfam02355 292563007125 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 292563007126 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 292563007127 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 292563007128 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 292563007129 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 292563007130 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 292563007131 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 292563007132 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 292563007133 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 292563007134 ribosomal protein S16; Region: rps16; CHL00005 292563007135 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 292563007136 KH domain; Region: KH_4; pfam13083 292563007137 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 292563007138 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 292563007139 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292563007140 homodimer interface [polypeptide binding]; other site 292563007141 catalytic residue [active] 292563007142 Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651 292563007143 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 292563007144 photosystem II reaction center protein Z; Provisional; Region: psbZ; PRK02576 292563007145 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 292563007146 homopentamer interface [polypeptide binding]; other site 292563007147 active site 292563007148 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 292563007149 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 292563007150 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 292563007151 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 292563007152 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 292563007153 Probable transposase; Region: OrfB_IS605; pfam01385 292563007154 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 292563007155 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 292563007156 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 292563007157 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 292563007158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 292563007159 dimer interface [polypeptide binding]; other site 292563007160 conserved gate region; other site 292563007161 putative PBP binding loops; other site 292563007162 ABC-ATPase subunit interface; other site 292563007163 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419 292563007164 UbiA prenyltransferase family; Region: UbiA; pfam01040 292563007165 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 292563007166 chorismate binding enzyme; Region: Chorismate_bind; cl10555 292563007167 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 292563007168 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 292563007169 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 292563007170 Transcriptional regulator [Transcription]; Region: LytR; COG1316 292563007171 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 292563007172 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563007173 active site 292563007174 phosphorylation site [posttranslational modification] 292563007175 intermolecular recognition site; other site 292563007176 dimerization interface [polypeptide binding]; other site 292563007177 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 292563007178 DNA binding site [nucleotide binding] 292563007179 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 292563007180 nudix motif; other site 292563007181 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 292563007182 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 292563007183 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 292563007184 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 292563007185 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 292563007186 DNA binding residues [nucleotide binding] 292563007187 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 292563007188 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 292563007189 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 292563007190 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 292563007191 Protein of unknown function (DUF3086); Region: DUF3086; pfam11285 292563007192 Protein of unknown function (DUF3119); Region: DUF3119; pfam11317 292563007193 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 292563007194 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 292563007195 putative catalytic cysteine [active] 292563007196 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 292563007197 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 292563007198 substrate binding site [chemical binding]; other site 292563007199 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 292563007200 mRNA/rRNA interface [nucleotide binding]; other site 292563007201 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 292563007202 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 292563007203 23S rRNA interface [nucleotide binding]; other site 292563007204 L7/L12 interface [polypeptide binding]; other site 292563007205 putative thiostrepton binding site; other site 292563007206 L25 interface [polypeptide binding]; other site 292563007207 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 292563007208 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 292563007209 putative homodimer interface [polypeptide binding]; other site 292563007210 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 292563007211 heterodimer interface [polypeptide binding]; other site 292563007212 homodimer interface [polypeptide binding]; other site 292563007213 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 292563007214 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 292563007215 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 292563007216 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 292563007217 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 292563007218 catalytic triad [active] 292563007219 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 292563007220 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 292563007221 active site 292563007222 HIGH motif; other site 292563007223 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 292563007224 active site 292563007225 KMSKS motif; other site 292563007226 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 292563007227 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 292563007228 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 292563007229 oligomer interface [polypeptide binding]; other site 292563007230 active site residues [active] 292563007231 Clp protease; Region: CLP_protease; pfam00574 292563007232 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 292563007233 oligomer interface [polypeptide binding]; other site 292563007234 active site residues [active] 292563007235 RNA recognition motif; Region: RRM; smart00360 292563007236 DnaJ domain; Region: DnaJ; pfam00226 292563007237 HSP70 interaction site [polypeptide binding]; other site 292563007238 Peptidase family M50; Region: Peptidase_M50; pfam02163 292563007239 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 292563007240 ArsC family; Region: ArsC; pfam03960 292563007241 catalytic residue [active] 292563007242 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 292563007243 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 292563007244 putative active site [active] 292563007245 Zn binding site [ion binding]; other site 292563007246 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 292563007247 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563007248 binding surface 292563007249 Tetratricopeptide repeat; Region: TPR_16; pfam13432 292563007250 TPR motif; other site 292563007251 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563007252 Tetratricopeptide repeat; Region: TPR_16; pfam13432 292563007253 TPR motif; other site 292563007254 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 292563007255 ABC1 family; Region: ABC1; pfam03109 292563007256 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 292563007257 active site 292563007258 ATP binding site [chemical binding]; other site 292563007259 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 292563007260 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 292563007261 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 292563007262 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 292563007263 Clp protease; Region: CLP_protease; pfam00574 292563007264 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 292563007265 oligomer interface [polypeptide binding]; other site 292563007266 active site residues [active] 292563007267 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 292563007268 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 292563007269 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 292563007270 Walker A motif; other site 292563007271 ATP binding site [chemical binding]; other site 292563007272 Walker B motif; other site 292563007273 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 292563007274 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 292563007275 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 292563007276 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 292563007277 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 292563007278 Protein of unknown function (DUF2488); Region: Ycf54; pfam10674 292563007279 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 292563007280 active site 292563007281 hydrophilic channel; other site 292563007282 dimerization interface [polypeptide binding]; other site 292563007283 catalytic residues [active] 292563007284 active site lid [active] 292563007285 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 292563007286 NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415 292563007287 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 292563007288 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 292563007289 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 292563007290 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 292563007291 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 292563007292 feedback inhibition sensing region; other site 292563007293 homohexameric interface [polypeptide binding]; other site 292563007294 nucleotide binding site [chemical binding]; other site 292563007295 N-acetyl-L-glutamate binding site [chemical binding]; other site 292563007296 DNA polymerase III subunit delta; Validated; Region: PRK07452 292563007297 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 292563007298 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 292563007299 Ligand Binding Site [chemical binding]; other site 292563007300 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 292563007301 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 292563007302 Substrate binding site; other site 292563007303 Cupin domain; Region: Cupin_2; cl17218 292563007304 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 292563007305 putative efflux protein, MATE family; Region: matE; TIGR00797 292563007306 cation binding site [ion binding]; other site 292563007307 lipoyl synthase; Provisional; Region: PRK12928 292563007308 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 292563007309 FeS/SAM binding site; other site 292563007310 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 292563007311 FAD binding domain; Region: FAD_binding_4; pfam01565 292563007312 Caspase domain; Region: Peptidase_C14; pfam00656 292563007313 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 292563007314 Walker A motif; other site 292563007315 ATP binding site [chemical binding]; other site 292563007316 Walker B motif; other site 292563007317 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 292563007318 protein-splicing catalytic site; other site 292563007319 thioester formation/cholesterol transfer; other site 292563007320 Pretoxin HINT domain; Region: PT-HINT; pfam07591 292563007321 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 292563007322 DNA polymerase III subunit delta'; Validated; Region: PRK08485 292563007323 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 292563007324 Tetratricopeptide repeat; Region: TPR_16; pfam13432 292563007325 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563007326 binding surface 292563007327 TPR repeat; Region: TPR_11; pfam13414 292563007328 TPR motif; other site 292563007329 Tetratricopeptide repeat; Region: TPR_12; pfam13424 292563007330 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 292563007331 RibD C-terminal domain; Region: RibD_C; cl17279 292563007332 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 292563007333 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 292563007334 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 292563007335 trimer interface [polypeptide binding]; other site 292563007336 active site 292563007337 substrate binding site [chemical binding]; other site 292563007338 CoA binding site [chemical binding]; other site 292563007339 Predicted permeases [General function prediction only]; Region: COG0795 292563007340 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 292563007341 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 292563007342 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 292563007343 Walker A/P-loop; other site 292563007344 ATP binding site [chemical binding]; other site 292563007345 Q-loop/lid; other site 292563007346 ABC transporter signature motif; other site 292563007347 Walker B; other site 292563007348 D-loop; other site 292563007349 H-loop/switch region; other site 292563007350 OstA-like protein; Region: OstA; cl00844 292563007351 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 292563007352 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 292563007353 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 292563007354 Protein of unknown function (DUF751); Region: DUF751; pfam05421 292563007355 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563007356 Response regulator receiver domain; Region: Response_reg; pfam00072 292563007357 active site 292563007358 phosphorylation site [posttranslational modification] 292563007359 intermolecular recognition site; other site 292563007360 dimerization interface [polypeptide binding]; other site 292563007361 Probable transposase; Region: OrfB_IS605; pfam01385 292563007362 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 292563007363 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 292563007364 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 292563007365 Probable transposase; Region: OrfB_IS605; pfam01385 292563007366 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 292563007367 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 292563007368 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 292563007369 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 292563007370 spermine synthase; Region: PLN02823 292563007371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292563007372 S-adenosylmethionine binding site [chemical binding]; other site 292563007373 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 292563007374 active site 292563007375 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 292563007376 Putative rhamnosyl transferase; Region: Rhamno_transf; pfam11316 292563007377 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05952 292563007378 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 292563007379 dimer interface [polypeptide binding]; other site 292563007380 active site 292563007381 phosphodiesterase; Provisional; Region: PRK12704 292563007382 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 292563007383 DHH family; Region: DHH; pfam01368 292563007384 DHHA1 domain; Region: DHHA1; pfam02272 292563007385 Predicted transcriptional regulator [Transcription]; Region: COG3682 292563007386 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 292563007387 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 292563007388 PUCC protein; Region: PUCC; pfam03209 292563007389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 292563007390 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 292563007391 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 292563007392 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 292563007393 metal binding site 2 [ion binding]; metal-binding site 292563007394 putative DNA binding helix; other site 292563007395 metal binding site 1 [ion binding]; metal-binding site 292563007396 dimer interface [polypeptide binding]; other site 292563007397 structural Zn2+ binding site [ion binding]; other site 292563007398 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 292563007399 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 292563007400 mercuric reductase; Validated; Region: PRK06370 292563007401 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 292563007402 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 292563007403 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 292563007404 Endonuclease, Uma2 family (restriction endonuclease fold) [General function prediction only]; Region: Uma2; COG4636 292563007405 Uncharacterized conserved protein [Function unknown]; Region: COG0398 292563007406 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 292563007407 Uncharacterized conserved protein [Function unknown]; Region: COG0398 292563007408 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 292563007409 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 292563007410 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 292563007411 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 292563007412 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 292563007413 DNA binding residues [nucleotide binding] 292563007414 putative anti-sigmaE protein; Provisional; Region: PRK13920 292563007415 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 292563007416 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 292563007417 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 292563007418 Probable transposase; Region: OrfB_IS605; pfam01385 292563007419 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 292563007420 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 292563007421 Walker A/P-loop; other site 292563007422 ATP binding site [chemical binding]; other site 292563007423 Q-loop/lid; other site 292563007424 ABC transporter signature motif; other site 292563007425 Walker B; other site 292563007426 D-loop; other site 292563007427 H-loop/switch region; other site 292563007428 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 292563007429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 292563007430 dimer interface [polypeptide binding]; other site 292563007431 conserved gate region; other site 292563007432 putative PBP binding loops; other site 292563007433 ABC-ATPase subunit interface; other site 292563007434 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 292563007435 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 292563007436 dimer interface [polypeptide binding]; other site 292563007437 conserved gate region; other site 292563007438 putative PBP binding loops; other site 292563007439 ABC-ATPase subunit interface; other site 292563007440 PBP superfamily domain; Region: PBP_like_2; cl17296 292563007441 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 292563007442 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 292563007443 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 292563007444 FeS/SAM binding site; other site 292563007445 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 292563007446 Methyltransferase domain; Region: Methyltransf_31; pfam13847 292563007447 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292563007448 S-adenosylmethionine binding site [chemical binding]; other site 292563007449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 292563007450 hypothetical protein; Provisional; Region: PRK02724 292563007451 haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1 292563007452 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 292563007453 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 292563007454 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 292563007455 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 292563007456 Probable transposase; Region: OrfB_IS605; pfam01385 292563007457 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 292563007458 Piccolo Zn-finger; Region: zf-piccolo; pfam05715 292563007459 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 292563007460 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 292563007461 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 292563007462 Ligand Binding Site [chemical binding]; other site 292563007463 Protein of unknown function (DUF3120); Region: DUF3120; pfam11318 292563007464 chaperone protein DnaJ; Provisional; Region: PRK14284 292563007465 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 292563007466 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 292563007467 active site 292563007468 dimerization interface [polypeptide binding]; other site 292563007469 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 292563007470 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 292563007471 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 292563007472 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 292563007473 putative ADP-binding pocket [chemical binding]; other site 292563007474 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 292563007475 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292563007476 Walker A/P-loop; other site 292563007477 ATP binding site [chemical binding]; other site 292563007478 Q-loop/lid; other site 292563007479 ABC transporter signature motif; other site 292563007480 Walker B; other site 292563007481 D-loop; other site 292563007482 H-loop/switch region; other site 292563007483 ABC transporter; Region: ABC_tran_2; pfam12848 292563007484 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 292563007485 ABC transporter; Region: ABC_tran_2; pfam12848 292563007486 ornithine carbamoyltransferase; Provisional; Region: PRK00779 292563007487 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 292563007488 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 292563007489 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 292563007490 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 292563007491 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 292563007492 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 292563007493 Ion channel; Region: Ion_trans_2; pfam07885 292563007494 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 292563007495 TrkA-N domain; Region: TrkA_N; pfam02254 292563007496 TrkA-C domain; Region: TrkA_C; pfam02080 292563007497 rod shape-determining protein MreB; Provisional; Region: PRK13927 292563007498 MreB and similar proteins; Region: MreB_like; cd10225 292563007499 nucleotide binding site [chemical binding]; other site 292563007500 Mg binding site [ion binding]; other site 292563007501 putative protofilament interaction site [polypeptide binding]; other site 292563007502 RodZ interaction site [polypeptide binding]; other site 292563007503 rod shape-determining protein MreC; Provisional; Region: PRK13922 292563007504 rod shape-determining protein MreC; Region: MreC; pfam04085 292563007505 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 292563007506 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 292563007507 FMN binding site [chemical binding]; other site 292563007508 active site 292563007509 catalytic residues [active] 292563007510 substrate binding site [chemical binding]; other site 292563007511 Recombination protein O N terminal; Region: RecO_N; pfam11967 292563007512 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 292563007513 Recombination protein O C terminal; Region: RecO_C; pfam02565 292563007514 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 292563007515 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 292563007516 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 292563007517 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292563007518 dimer interface [polypeptide binding]; other site 292563007519 phosphorylation site [posttranslational modification] 292563007520 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292563007521 ATP binding site [chemical binding]; other site 292563007522 Mg2+ binding site [ion binding]; other site 292563007523 G-X-G motif; other site 292563007524 Response regulator receiver domain; Region: Response_reg; pfam00072 292563007525 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563007526 active site 292563007527 phosphorylation site [posttranslational modification] 292563007528 intermolecular recognition site; other site 292563007529 dimerization interface [polypeptide binding]; other site 292563007530 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 292563007531 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 292563007532 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 292563007533 anti sigma factor interaction site; other site 292563007534 regulatory phosphorylation site [posttranslational modification]; other site 292563007535 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 292563007536 active site 292563007537 metal binding site [ion binding]; metal-binding site 292563007538 dimerization interface [polypeptide binding]; other site 292563007539 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 292563007540 Nitrogen regulatory protein P-II; Region: P-II; smart00938 292563007541 glycogen synthase; Provisional; Region: glgA; PRK00654 292563007542 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 292563007543 ADP-binding pocket [chemical binding]; other site 292563007544 homodimer interface [polypeptide binding]; other site 292563007545 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 292563007546 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 292563007547 nucleotide binding site [chemical binding]; other site 292563007548 NEF interaction site [polypeptide binding]; other site 292563007549 SBD interface [polypeptide binding]; other site 292563007550 Protein of unknown function (DUF3082); Region: DUF3082; pfam11282 292563007551 Protein of unknown function (DUF2605); Region: DUF2605; pfam10792 292563007552 Protein of unknown function (DUF2973); Region: DUF2973; pfam11189 292563007553 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 292563007554 intersubunit interface [polypeptide binding]; other site 292563007555 active site 292563007556 catalytic residue [active] 292563007557 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 292563007558 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 292563007559 dimerization interface [polypeptide binding]; other site 292563007560 active site 292563007561 metal binding site [ion binding]; metal-binding site 292563007562 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 292563007563 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 292563007564 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 292563007565 C-terminal domain interface [polypeptide binding]; other site 292563007566 GSH binding site (G-site) [chemical binding]; other site 292563007567 dimer interface [polypeptide binding]; other site 292563007568 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 292563007569 N-terminal domain interface [polypeptide binding]; other site 292563007570 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 292563007571 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 292563007572 substrate binding pocket [chemical binding]; other site 292563007573 Ion channel; Region: Ion_trans_2; pfam07885 292563007574 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 292563007575 membrane-bound complex binding site; other site 292563007576 hinge residues; other site 292563007577 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 292563007578 NADH(P)-binding; Region: NAD_binding_10; pfam13460 292563007579 NAD(P) binding site [chemical binding]; other site 292563007580 putative active site [active] 292563007581 Uncharacterized conserved protein containing a coiled-coil domain [Function unknown]; Region: COG5493 292563007582 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 292563007583 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 292563007584 Walker A/P-loop; other site 292563007585 ATP binding site [chemical binding]; other site 292563007586 Q-loop/lid; other site 292563007587 ABC transporter signature motif; other site 292563007588 Walker B; other site 292563007589 D-loop; other site 292563007590 H-loop/switch region; other site 292563007591 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 292563007592 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 292563007593 Walker A/P-loop; other site 292563007594 ATP binding site [chemical binding]; other site 292563007595 Q-loop/lid; other site 292563007596 ABC transporter signature motif; other site 292563007597 Walker B; other site 292563007598 D-loop; other site 292563007599 H-loop/switch region; other site 292563007600 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 292563007601 NMT1-like family; Region: NMT1_2; pfam13379 292563007602 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 292563007603 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 292563007604 dimer interface [polypeptide binding]; other site 292563007605 conserved gate region; other site 292563007606 putative PBP binding loops; other site 292563007607 ABC-ATPase subunit interface; other site 292563007608 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 292563007609 NMT1-like family; Region: NMT1_2; pfam13379 292563007610 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 292563007611 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 292563007612 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 292563007613 Walker A/P-loop; other site 292563007614 ATP binding site [chemical binding]; other site 292563007615 Q-loop/lid; other site 292563007616 ABC transporter signature motif; other site 292563007617 Walker B; other site 292563007618 D-loop; other site 292563007619 H-loop/switch region; other site 292563007620 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 292563007621 phosphopeptide binding site; other site 292563007622 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 292563007623 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 292563007624 phosphopeptide binding site; other site 292563007625 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 292563007626 The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955 292563007627 Walker A/P-loop; other site 292563007628 ATP binding site [chemical binding]; other site 292563007629 Q-loop/lid; other site 292563007630 ABC transporter signature motif; other site 292563007631 Walker B; other site 292563007632 D-loop; other site 292563007633 H-loop/switch region; other site 292563007634 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 292563007635 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 292563007636 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 292563007637 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 292563007638 O-Antigen ligase; Region: Wzy_C; pfam04932 292563007639 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 292563007640 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 292563007641 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 292563007642 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 292563007643 Walker A/P-loop; other site 292563007644 ATP binding site [chemical binding]; other site 292563007645 Q-loop/lid; other site 292563007646 ABC transporter signature motif; other site 292563007647 Walker B; other site 292563007648 D-loop; other site 292563007649 H-loop/switch region; other site 292563007650 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 292563007651 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 292563007652 P-loop, Walker A motif; other site 292563007653 Base recognition motif; other site 292563007654 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 292563007655 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 292563007656 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 292563007657 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 292563007658 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292563007659 dimer interface [polypeptide binding]; other site 292563007660 phosphorylation site [posttranslational modification] 292563007661 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292563007662 ATP binding site [chemical binding]; other site 292563007663 Mg2+ binding site [ion binding]; other site 292563007664 G-X-G motif; other site 292563007665 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563007666 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 292563007667 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563007668 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563007669 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563007670 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563007671 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 292563007672 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563007673 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563007674 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 292563007675 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 292563007676 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 292563007677 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 292563007678 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 292563007679 putative substrate translocation pore; other site 292563007680 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 292563007681 Probable transposase; Region: OrfB_IS605; pfam01385 292563007682 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 292563007683 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 292563007684 Late competence development protein ComFB; Region: ComFB; pfam10719 292563007685 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 292563007686 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 292563007687 metal-binding site [ion binding] 292563007688 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 292563007689 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 292563007690 motif II; other site 292563007691 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 292563007692 phosphopeptide binding site; other site 292563007693 AMIN domain; Region: AMIN; pfam11741 292563007694 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 292563007695 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 292563007696 active site 292563007697 metal binding site [ion binding]; metal-binding site 292563007698 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 292563007699 oligomerization interface [polypeptide binding]; other site 292563007700 active site 292563007701 metal binding site [ion binding]; metal-binding site 292563007702 phosphoglucomutase; Region: PLN02307 292563007703 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 292563007704 substrate binding site [chemical binding]; other site 292563007705 dimer interface [polypeptide binding]; other site 292563007706 active site 292563007707 metal binding site [ion binding]; metal-binding site 292563007708 PemK-like protein; Region: PemK; cl00995 292563007709 Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336 292563007710 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cd09852 292563007711 putative active site [active] 292563007712 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 292563007713 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 292563007714 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 292563007715 Probable transposase; Region: OrfB_IS605; pfam01385 292563007716 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 292563007717 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 292563007718 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 292563007719 putative active site [active] 292563007720 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 292563007721 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 292563007722 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 292563007723 transmembrane helices; other site 292563007724 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 292563007725 Clp protease ATP binding subunit; Region: clpC; CHL00095 292563007726 Clp amino terminal domain; Region: Clp_N; pfam02861 292563007727 Clp amino terminal domain; Region: Clp_N; pfam02861 292563007728 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 292563007729 Walker A motif; other site 292563007730 ATP binding site [chemical binding]; other site 292563007731 Walker B motif; other site 292563007732 arginine finger; other site 292563007733 UvrB/uvrC motif; Region: UVR; pfam02151 292563007734 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 292563007735 Walker A motif; other site 292563007736 ATP binding site [chemical binding]; other site 292563007737 Walker B motif; other site 292563007738 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 292563007739 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 292563007740 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 292563007741 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 292563007742 MltA specific insert domain; Region: MltA; pfam03562 292563007743 3D domain; Region: 3D; pfam06725 292563007744 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 292563007745 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 292563007746 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 292563007747 heme binding pocket [chemical binding]; other site 292563007748 heme ligand [chemical binding]; other site 292563007749 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 292563007750 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 292563007751 active site 292563007752 catalytic tetrad [active] 292563007753 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 292563007754 Coenzyme A binding pocket [chemical binding]; other site 292563007755 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 292563007756 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 292563007757 Ligand binding site; other site 292563007758 Putative Catalytic site; other site 292563007759 DXD motif; other site 292563007760 Predicted membrane protein [Function unknown]; Region: COG2246 292563007761 GtrA-like protein; Region: GtrA; pfam04138 292563007762 ribosome maturation protein RimP; Reviewed; Region: PRK00092 292563007763 Sm and related proteins; Region: Sm_like; cl00259 292563007764 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 292563007765 putative oligomer interface [polypeptide binding]; other site 292563007766 putative RNA binding site [nucleotide binding]; other site 292563007767 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 292563007768 NusA N-terminal domain; Region: NusA_N; pfam08529 292563007769 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 292563007770 RNA binding site [nucleotide binding]; other site 292563007771 homodimer interface [polypeptide binding]; other site 292563007772 NusA-like KH domain; Region: KH_5; pfam13184 292563007773 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 292563007774 G-X-X-G motif; other site 292563007775 Protein of unknown function (DUF448); Region: DUF448; pfam04296 292563007776 putative RNA binding cleft [nucleotide binding]; other site 292563007777 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 292563007778 translation initiation factor IF-2; Region: IF-2; TIGR00487 292563007779 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 292563007780 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 292563007781 G1 box; other site 292563007782 putative GEF interaction site [polypeptide binding]; other site 292563007783 GTP/Mg2+ binding site [chemical binding]; other site 292563007784 Switch I region; other site 292563007785 G2 box; other site 292563007786 G3 box; other site 292563007787 Switch II region; other site 292563007788 G4 box; other site 292563007789 G5 box; other site 292563007790 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 292563007791 Translation-initiation factor 2; Region: IF-2; pfam11987 292563007792 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 292563007793 Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664 292563007794 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 292563007795 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 292563007796 substrate binding site [chemical binding]; other site 292563007797 ligand binding site [chemical binding]; other site 292563007798 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 292563007799 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 292563007800 Probable transposase; Region: OrfB_IS605; pfam01385 292563007801 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 292563007802 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 292563007803 Domain of unknown function (DUF1817); Region: DUF1817; pfam08847 292563007804 Haemolytic domain; Region: Haemolytic; pfam01809 292563007805 HEAT repeats; Region: HEAT_2; pfam13646 292563007806 HEAT repeats; Region: HEAT_2; pfam13646 292563007807 HEAT repeats; Region: HEAT_2; pfam13646 292563007808 threonine synthase; Validated; Region: PRK06260 292563007809 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 292563007810 homodimer interface [polypeptide binding]; other site 292563007811 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292563007812 catalytic residue [active] 292563007813 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 292563007814 active site residue [active] 292563007815 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 292563007816 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 292563007817 FMN binding site [chemical binding]; other site 292563007818 active site 292563007819 catalytic residues [active] 292563007820 substrate binding site [chemical binding]; other site 292563007821 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 292563007822 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 292563007823 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 292563007824 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 292563007825 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 292563007826 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 292563007827 dimer interface [polypeptide binding]; other site 292563007828 decamer (pentamer of dimers) interface [polypeptide binding]; other site 292563007829 catalytic triad [active] 292563007830 peroxidatic and resolving cysteines [active] 292563007831 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 292563007832 Family description; Region: UvrD_C_2; pfam13538 292563007833 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 292563007834 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 292563007835 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 292563007836 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 292563007837 CAAX protease self-immunity; Region: Abi; pfam02517 292563007838 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 292563007839 succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12577 292563007840 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 292563007841 AMIN domain; Region: AMIN; pfam11741 292563007842 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 292563007843 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 292563007844 active site 292563007845 metal binding site [ion binding]; metal-binding site 292563007846 glutamate racemase; Provisional; Region: PRK00865 292563007847 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 292563007848 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 292563007849 putative active site [active] 292563007850 Zn binding site [ion binding]; other site 292563007851 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 292563007852 AIR carboxylase; Region: AIRC; smart01001 292563007853 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 292563007854 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 292563007855 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 292563007856 substrate binding site [chemical binding]; other site 292563007857 catalytic Zn binding site [ion binding]; other site 292563007858 NAD binding site [chemical binding]; other site 292563007859 structural Zn binding site [ion binding]; other site 292563007860 dimer interface [polypeptide binding]; other site 292563007861 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 292563007862 RimK-like ATP-grasp domain; Region: RimK; pfam08443 292563007863 Proline dehydrogenase; Region: Pro_dh; pfam01619 292563007864 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 292563007865 delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; Region: D1pyr5carbox2; TIGR01237 292563007866 Glutamate binding site [chemical binding]; other site 292563007867 homodimer interface [polypeptide binding]; other site 292563007868 NAD binding site [chemical binding]; other site 292563007869 catalytic residues [active] 292563007870 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 292563007871 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 292563007872 E3 interaction surface; other site 292563007873 lipoyl attachment site [posttranslational modification]; other site 292563007874 e3 binding domain; Region: E3_binding; pfam02817 292563007875 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 292563007876 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 292563007877 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 292563007878 Domain of unknown function (DUF1818); Region: DUF1818; pfam08848 292563007879 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 292563007880 Uncharacterized conserved protein [Function unknown]; Region: COG2361 292563007881 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 292563007882 active site 292563007883 NTP binding site [chemical binding]; other site 292563007884 metal binding triad [ion binding]; metal-binding site 292563007885 antibiotic binding site [chemical binding]; other site 292563007886 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 292563007887 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 292563007888 protein binding site [polypeptide binding]; other site 292563007889 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 292563007890 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346 292563007891 putative ligand binding site [chemical binding]; other site 292563007892 Methyltransferase domain; Region: Methyltransf_23; pfam13489 292563007893 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 292563007894 phosphatidate cytidylyltransferase; Region: PLN02953 292563007895 methionine sulfoxide reductase B; Provisional; Region: PRK00222 292563007896 SelR domain; Region: SelR; pfam01641 292563007897 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 292563007898 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292563007899 dimer interface [polypeptide binding]; other site 292563007900 phosphorylation site [posttranslational modification] 292563007901 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292563007902 ATP binding site [chemical binding]; other site 292563007903 Mg2+ binding site [ion binding]; other site 292563007904 G-X-G motif; other site 292563007905 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 292563007906 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 292563007907 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 292563007908 active site 292563007909 homodimer interface [polypeptide binding]; other site 292563007910 catalytic site [active] 292563007911 Domain of unknown function DUF21; Region: DUF21; pfam01595 292563007912 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 292563007913 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 292563007914 acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100 292563007915 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 292563007916 putative valine binding site [chemical binding]; other site 292563007917 dimer interface [polypeptide binding]; other site 292563007918 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 292563007919 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 292563007920 Catalytic domain of Protein Kinases; Region: PKc; cd00180 292563007921 active site 292563007922 ATP binding site [chemical binding]; other site 292563007923 substrate binding site [chemical binding]; other site 292563007924 activation loop (A-loop); other site 292563007925 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 292563007926 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 292563007927 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 292563007928 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 292563007929 active site 292563007930 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 292563007931 Permease; Region: Permease; cl00510 292563007932 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 292563007933 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 292563007934 potential catalytic triad [active] 292563007935 conserved cys residue [active] 292563007936 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 292563007937 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 292563007938 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 292563007939 FeS/SAM binding site; other site 292563007940 thiamine monophosphate kinase; Provisional; Region: PRK05731 292563007941 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 292563007942 ATP binding site [chemical binding]; other site 292563007943 dimerization interface [polypeptide binding]; other site 292563007944 Response regulator receiver domain; Region: Response_reg; pfam00072 292563007945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563007946 active site 292563007947 phosphorylation site [posttranslational modification] 292563007948 intermolecular recognition site; other site 292563007949 dimerization interface [polypeptide binding]; other site 292563007950 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 292563007951 Glucose inhibited division protein A; Region: GIDA; pfam01134 292563007952 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 292563007953 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 292563007954 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 292563007955 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 292563007956 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 292563007957 TMP-binding site; other site 292563007958 ATP-binding site [chemical binding]; other site 292563007959 Protein of unknown function (DUF1622); Region: DUF1622; cl01991 292563007960 molecular chaperone DnaK; Provisional; Region: PRK13411 292563007961 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 292563007962 nucleotide binding site [chemical binding]; other site 292563007963 NEF interaction site [polypeptide binding]; other site 292563007964 SBD interface [polypeptide binding]; other site 292563007965 GrpE; Region: GrpE; pfam01025 292563007966 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 292563007967 dimer interface [polypeptide binding]; other site 292563007968 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 292563007969 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 292563007970 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 292563007971 Zn binding site [ion binding]; other site 292563007972 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 292563007973 PIN domain; Region: PIN_3; cl17397 292563007974 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 292563007975 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 292563007976 Walker A/P-loop; other site 292563007977 ATP binding site [chemical binding]; other site 292563007978 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 292563007979 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 292563007980 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 292563007981 ABC transporter signature motif; other site 292563007982 Walker B; other site 292563007983 D-loop; other site 292563007984 H-loop/switch region; other site 292563007985 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 292563007986 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 292563007987 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 292563007988 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 292563007989 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 292563007990 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 292563007991 active site 292563007992 catalytic tetrad [active] 292563007993 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 292563007994 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292563007995 S-adenosylmethionine binding site [chemical binding]; other site 292563007996 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 292563007997 Protein of unknown function (DUF3148); Region: DUF3148; pfam11347 292563007998 Protein of unknown function (DUF98); Region: DUF98; pfam01947 292563007999 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 292563008000 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 292563008001 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 292563008002 Walker A/P-loop; other site 292563008003 ATP binding site [chemical binding]; other site 292563008004 Q-loop/lid; other site 292563008005 ABC transporter signature motif; other site 292563008006 Walker B; other site 292563008007 D-loop; other site 292563008008 H-loop/switch region; other site 292563008009 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 292563008010 CoA binding domain; Region: CoA_binding_2; pfam13380 292563008011 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 292563008012 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 292563008013 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 292563008014 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 292563008015 Coenzyme A binding pocket [chemical binding]; other site 292563008016 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 292563008017 Aluminium resistance protein; Region: Alum_res; pfam06838 292563008018 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 292563008019 metal ion-dependent adhesion site (MIDAS); other site 292563008020 chaperone protein DnaJ; Provisional; Region: PRK14299 292563008021 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 292563008022 HSP70 interaction site [polypeptide binding]; other site 292563008023 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 292563008024 dimer interface [polypeptide binding]; other site 292563008025 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 292563008026 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 292563008027 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 292563008028 active site 292563008029 putative homodimer interface [polypeptide binding]; other site 292563008030 SAM binding site [chemical binding]; other site 292563008031 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 292563008032 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292563008033 S-adenosylmethionine binding site [chemical binding]; other site 292563008034 Response regulator receiver domain; Region: Response_reg; pfam00072 292563008035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563008036 active site 292563008037 phosphorylation site [posttranslational modification] 292563008038 intermolecular recognition site; other site 292563008039 dimerization interface [polypeptide binding]; other site 292563008040 CheW-like domain; Region: CheW; pfam01584 292563008041 HAMP domain; Region: HAMP; pfam00672 292563008042 dimerization interface [polypeptide binding]; other site 292563008043 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 292563008044 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 292563008045 dimer interface [polypeptide binding]; other site 292563008046 putative CheW interface [polypeptide binding]; other site 292563008047 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 292563008048 putative binding surface; other site 292563008049 active site 292563008050 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 292563008051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292563008052 ATP binding site [chemical binding]; other site 292563008053 Mg2+ binding site [ion binding]; other site 292563008054 G-X-G motif; other site 292563008055 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 292563008056 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 292563008057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563008058 active site 292563008059 phosphorylation site [posttranslational modification] 292563008060 intermolecular recognition site; other site 292563008061 dimerization interface [polypeptide binding]; other site 292563008062 Response regulator receiver domain; Region: Response_reg; pfam00072 292563008063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563008064 active site 292563008065 phosphorylation site [posttranslational modification] 292563008066 intermolecular recognition site; other site 292563008067 dimerization interface [polypeptide binding]; other site 292563008068 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 292563008069 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 292563008070 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 292563008071 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 292563008072 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 292563008073 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 292563008074 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 292563008075 AAA domain; Region: AAA_17; pfam13207 292563008076 AAA domain; Region: AAA_33; pfam13671 292563008077 D2 subunit of photosystem II (PS II); Region: Photosystem-II_D2; cd09288 292563008078 D1 interface; other site 292563008079 chlorophyll binding site; other site 292563008080 pheophytin binding site; other site 292563008081 beta carotene binding site; other site 292563008082 cytochrome b559 beta interface; other site 292563008083 quinone binding site; other site 292563008084 cytochrome b559 alpha interface; other site 292563008085 protein J interface; other site 292563008086 protein H interface; other site 292563008087 protein X interface; other site 292563008088 core light harvesting protein interface; other site 292563008089 protein L interface; other site 292563008090 CP43 interface; other site 292563008091 protein T interface; other site 292563008092 Fe binding site [ion binding]; other site 292563008093 protein M interface; other site 292563008094 Mn-stabilizing polypeptide interface; other site 292563008095 bromide binding site; other site 292563008096 cytochrome c-550 interface; other site 292563008097 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 292563008098 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 292563008099 C-terminal domain interface [polypeptide binding]; other site 292563008100 active site 292563008101 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 292563008102 active site 292563008103 N-terminal domain interface [polypeptide binding]; other site 292563008104 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 292563008105 c-type cytochrome biogenensis protein; Validated; Region: ccs1; CHL00177 292563008106 ResB-like family; Region: ResB; pfam05140 292563008107 NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909 292563008108 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 292563008109 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 292563008110 Walker A motif; other site 292563008111 ATP binding site [chemical binding]; other site 292563008112 Walker B motif; other site 292563008113 R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645 292563008114 RxxxH motif; other site 292563008115 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 292563008116 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 292563008117 Catalytic domain of Protein Kinases; Region: PKc; cd00180 292563008118 active site 292563008119 ATP binding site [chemical binding]; other site 292563008120 substrate binding site [chemical binding]; other site 292563008121 activation loop (A-loop); other site 292563008122 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563008123 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 292563008124 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563008125 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 292563008126 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 292563008127 homodimer interface [polypeptide binding]; other site 292563008128 substrate-cofactor binding pocket; other site 292563008129 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292563008130 catalytic residue [active] 292563008131 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 292563008132 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 292563008133 Cytochrome P450; Region: p450; cl12078 292563008134 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 292563008135 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 292563008136 active site 292563008137 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 292563008138 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 292563008139 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 292563008140 putative switch regulator; other site 292563008141 non-specific DNA interactions [nucleotide binding]; other site 292563008142 DNA binding site [nucleotide binding] 292563008143 sequence specific DNA binding site [nucleotide binding]; other site 292563008144 putative cAMP binding site [chemical binding]; other site 292563008145 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 292563008146 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 292563008147 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 292563008148 catalytic residue [active] 292563008149 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 292563008150 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 292563008151 putative active site [active] 292563008152 Putative ATP-dependent Lon protease; Region: Lon_2; cl11979 292563008153 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 292563008154 Protein of unknown function (DUF4007); Region: DUF4007; pfam13182 292563008155 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 292563008156 HNH endonuclease; Region: HNH_4; pfam13395 292563008157 Protein of unknown function (DUF4007); Region: DUF4007; pfam13182 292563008158 hypothetical protein; Provisional; Region: PRK10621 292563008159 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 292563008160 Domain of unknown function (DUF202); Region: DUF202; pfam02656 292563008161 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 292563008162 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 292563008163 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 292563008164 sulfate transport protein; Provisional; Region: cysT; CHL00187 292563008165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 292563008166 dimer interface [polypeptide binding]; other site 292563008167 conserved gate region; other site 292563008168 putative PBP binding loops; other site 292563008169 ABC-ATPase subunit interface; other site 292563008170 sulfate transport protein; Provisional; Region: cysT; CHL00187 292563008171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 292563008172 dimer interface [polypeptide binding]; other site 292563008173 conserved gate region; other site 292563008174 putative PBP binding loops; other site 292563008175 ABC-ATPase subunit interface; other site 292563008176 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 292563008177 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 292563008178 Walker A/P-loop; other site 292563008179 ATP binding site [chemical binding]; other site 292563008180 Q-loop/lid; other site 292563008181 ABC transporter signature motif; other site 292563008182 Walker B; other site 292563008183 D-loop; other site 292563008184 H-loop/switch region; other site 292563008185 TOBE-like domain; Region: TOBE_3; pfam12857 292563008186 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563008187 binding surface 292563008188 TPR motif; other site 292563008189 TPR repeat; Region: TPR_11; pfam13414 292563008190 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563008191 binding surface 292563008192 TPR repeat; Region: TPR_11; pfam13414 292563008193 TPR motif; other site 292563008194 Protein of unknown function (DUF563); Region: DUF563; pfam04577 292563008195 TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950 292563008196 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 292563008197 catalytic residues [active] 292563008198 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 292563008199 4Fe-4S binding domain; Region: Fer4; pfam00037 292563008200 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 292563008201 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 292563008202 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 292563008203 Probable transposase; Region: OrfB_IS605; pfam01385 292563008204 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 292563008205 Domain of unknown function (DUF1824); Region: DUF1824; pfam08854 292563008206 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 292563008207 metal binding site 2 [ion binding]; metal-binding site 292563008208 putative DNA binding helix; other site 292563008209 metal binding site 1 [ion binding]; metal-binding site 292563008210 dimer interface [polypeptide binding]; other site 292563008211 structural Zn2+ binding site [ion binding]; other site 292563008212 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 292563008213 catalytic triad [active] 292563008214 dimer interface [polypeptide binding]; other site 292563008215 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 292563008216 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 292563008217 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 292563008218 MoaE interaction surface [polypeptide binding]; other site 292563008219 MoeB interaction surface [polypeptide binding]; other site 292563008220 thiocarboxylated glycine; other site 292563008221 hypothetical protein; Provisional; Region: PRK13683 292563008222 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 292563008223 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 292563008224 Walker A/P-loop; other site 292563008225 ATP binding site [chemical binding]; other site 292563008226 Q-loop/lid; other site 292563008227 ABC transporter signature motif; other site 292563008228 Walker B; other site 292563008229 D-loop; other site 292563008230 H-loop/switch region; other site 292563008231 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 292563008232 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563008233 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563008234 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 292563008235 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 292563008236 active site 292563008237 catalytic site [active] 292563008238 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 292563008239 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 292563008240 Ligand Binding Site [chemical binding]; other site 292563008241 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 292563008242 Lipase (class 2); Region: Lipase_2; pfam01674 292563008243 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 292563008244 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 292563008245 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 292563008246 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 292563008247 RNA binding surface [nucleotide binding]; other site 292563008248 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 292563008249 active site 292563008250 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 292563008251 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 292563008252 active site 292563008253 Substrate binding site; other site 292563008254 Mg++ binding site; other site 292563008255 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 292563008256 putative trimer interface [polypeptide binding]; other site 292563008257 putative CoA binding site [chemical binding]; other site 292563008258 Catalytic domain of Protein Kinases; Region: PKc; cd00180 292563008259 Protein kinase domain; Region: Pkinase; pfam00069 292563008260 active site 292563008261 ATP binding site [chemical binding]; other site 292563008262 substrate binding site [chemical binding]; other site 292563008263 activation loop (A-loop); other site 292563008264 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563008265 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 292563008266 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563008267 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563008268 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 292563008269 Catalytic domain of Protein Kinases; Region: PKc; cd00180 292563008270 active site 292563008271 ATP binding site [chemical binding]; other site 292563008272 substrate binding site [chemical binding]; other site 292563008273 activation loop (A-loop); other site 292563008274 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 292563008275 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563008276 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563008277 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563008278 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 292563008279 Protein of unknown function (DUF3685); Region: DUF3685; pfam12452 292563008280 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 292563008281 metal binding site 2 [ion binding]; metal-binding site 292563008282 putative DNA binding helix; other site 292563008283 metal binding site 1 [ion binding]; metal-binding site 292563008284 dimer interface [polypeptide binding]; other site 292563008285 structural Zn2+ binding site [ion binding]; other site 292563008286 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 292563008287 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 292563008288 Probable transposase; Region: OrfB_IS605; pfam01385 292563008289 Conserved TM helix; Region: TM_helix; pfam05552 292563008290 Conserved TM helix; Region: TM_helix; pfam05552 292563008291 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 292563008292 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 292563008293 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 292563008294 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 292563008295 putative active site [active] 292563008296 rod shape-determining protein MreD; Region: MreD; cl01087 292563008297 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 292563008298 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 292563008299 TM-ABC transporter signature motif; other site 292563008300 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 292563008301 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 292563008302 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 292563008303 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 292563008304 heterotetramer interface [polypeptide binding]; other site 292563008305 active site pocket [active] 292563008306 cleavage site 292563008307 Uncharacterized conserved protein [Function unknown]; Region: COG5464 292563008308 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 292563008309 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 292563008310 Uncharacterized conserved protein [Function unknown]; Region: COG5464 292563008311 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 292563008312 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 292563008313 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 292563008314 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 292563008315 Walker A/P-loop; other site 292563008316 ATP binding site [chemical binding]; other site 292563008317 Q-loop/lid; other site 292563008318 ABC transporter signature motif; other site 292563008319 Walker B; other site 292563008320 D-loop; other site 292563008321 H-loop/switch region; other site 292563008322 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 292563008323 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 292563008324 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 292563008325 Surface antigen; Region: Bac_surface_Ag; pfam01103 292563008326 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 292563008327 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 292563008328 ATP binding site [chemical binding]; other site 292563008329 active site 292563008330 substrate binding site [chemical binding]; other site 292563008331 dihydroorotase; Provisional; Region: PRK07369 292563008332 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 292563008333 active site 292563008334 Protein of unknown function, DUF393; Region: DUF393; pfam04134 292563008335 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 292563008336 active site 292563008337 catalytic triad [active] 292563008338 oxyanion hole [active] 292563008339 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 292563008340 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 292563008341 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 292563008342 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 292563008343 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 292563008344 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 292563008345 putative binding surface; other site 292563008346 active site 292563008347 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 292563008348 HlyD family secretion protein; Region: HlyD_3; pfam13437 292563008349 DevC protein; Region: devC; TIGR01185 292563008350 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 292563008351 FtsX-like permease family; Region: FtsX; pfam02687 292563008352 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 292563008353 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 292563008354 Walker A/P-loop; other site 292563008355 ATP binding site [chemical binding]; other site 292563008356 Q-loop/lid; other site 292563008357 ABC transporter signature motif; other site 292563008358 Walker B; other site 292563008359 D-loop; other site 292563008360 H-loop/switch region; other site 292563008361 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 292563008362 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 292563008363 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 292563008364 putative active site [active] 292563008365 putative substrate binding site [chemical binding]; other site 292563008366 putative cosubstrate binding site; other site 292563008367 catalytic site [active] 292563008368 Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069 292563008369 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 292563008370 metal binding site 2 [ion binding]; metal-binding site 292563008371 putative DNA binding helix; other site 292563008372 metal binding site 1 [ion binding]; metal-binding site 292563008373 dimer interface [polypeptide binding]; other site 292563008374 structural Zn2+ binding site [ion binding]; other site 292563008375 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 292563008376 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 292563008377 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292563008378 ATP binding site [chemical binding]; other site 292563008379 Mg2+ binding site [ion binding]; other site 292563008380 G-X-G motif; other site 292563008381 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 292563008382 Response regulator receiver domain; Region: Response_reg; pfam00072 292563008383 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563008384 active site 292563008385 phosphorylation site [posttranslational modification] 292563008386 intermolecular recognition site; other site 292563008387 dimerization interface [polypeptide binding]; other site 292563008388 Response regulator receiver domain; Region: Response_reg; pfam00072 292563008389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563008390 active site 292563008391 phosphorylation site [posttranslational modification] 292563008392 intermolecular recognition site; other site 292563008393 dimerization interface [polypeptide binding]; other site 292563008394 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 292563008395 substrate binding site; other site 292563008396 dimer interface; other site 292563008397 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 292563008398 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 292563008399 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 292563008400 catalytic residue [active] 292563008401 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 292563008402 Short C-terminal domain; Region: SHOCT; pfam09851 292563008403 Domain of unknown function (DUF1825); Region: DUF1825; pfam08855 292563008404 Protein of unknown function (DUF760); Region: DUF760; pfam05542 292563008405 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 292563008406 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 292563008407 polyphosphate kinase; Provisional; Region: PRK05443 292563008408 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 292563008409 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 292563008410 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 292563008411 putative domain interface [polypeptide binding]; other site 292563008412 putative active site [active] 292563008413 catalytic site [active] 292563008414 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 292563008415 putative domain interface [polypeptide binding]; other site 292563008416 putative active site [active] 292563008417 catalytic site [active] 292563008418 photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515 292563008419 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 292563008420 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 292563008421 dimer interface [polypeptide binding]; other site 292563008422 decamer (pentamer of dimers) interface [polypeptide binding]; other site 292563008423 catalytic triad [active] 292563008424 putative phosphate acyltransferase; Provisional; Region: PRK05331 292563008425 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 292563008426 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 292563008427 dimer interface [polypeptide binding]; other site 292563008428 active site 292563008429 CoA binding pocket [chemical binding]; other site 292563008430 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 292563008431 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 292563008432 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563008433 binding surface 292563008434 Tetratricopeptide repeat; Region: TPR_16; pfam13432 292563008435 TPR motif; other site 292563008436 TPR repeat; Region: TPR_11; pfam13414 292563008437 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563008438 binding surface 292563008439 TPR motif; other site 292563008440 Tetratricopeptide repeat; Region: TPR_16; pfam13432 292563008441 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 292563008442 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 292563008443 dimer interface [polypeptide binding]; other site 292563008444 conserved gate region; other site 292563008445 ABC-ATPase subunit interface; other site 292563008446 Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279 292563008447 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 292563008448 flavodoxin FldA; Validated; Region: PRK09267 292563008449 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 292563008450 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 292563008451 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292563008452 S-adenosylmethionine binding site [chemical binding]; other site 292563008453 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 292563008454 putative ABC transporter; Region: ycf24; CHL00085 292563008455 Photosystem I reaction centre subunit XI; Region: PsaL; pfam02605 292563008456 photosystem I reaction center subunit VIII; Reviewed; Region: psaI; PRK11877 292563008457 tRNA synthetases class I (I, L, M and V); Region: tRNA-synt_1; pfam00133 292563008458 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 292563008459 active site 292563008460 HIGH motif; other site 292563008461 nucleotide binding site [chemical binding]; other site 292563008462 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 292563008463 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 292563008464 active site 292563008465 KMSKS motif; other site 292563008466 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 292563008467 tRNA binding surface [nucleotide binding]; other site 292563008468 anticodon binding site; other site 292563008469 Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264 292563008470 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 292563008471 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 292563008472 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 292563008473 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 292563008474 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 292563008475 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 292563008476 Photosystem II reaction centre X protein (PsbX); Region: PsbX; pfam06596 292563008477 Predicted integral membrane protein [Function unknown]; Region: COG0762 292563008478 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 292563008479 homooctamer interface [polypeptide binding]; other site 292563008480 active site 292563008481 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 292563008482 arginine-tRNA ligase; Region: PLN02286 292563008483 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 292563008484 active site 292563008485 HIGH motif; other site 292563008486 KMSK motif region; other site 292563008487 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 292563008488 tRNA binding surface [nucleotide binding]; other site 292563008489 anticodon binding site; other site 292563008490 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 292563008491 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 292563008492 Protein of unknown function (DUF721); Region: DUF721; cl02324 292563008493 photosystem I subunit VII; Region: psaC; CHL00065 292563008494 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 292563008495 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 292563008496 homotrimer interaction site [polypeptide binding]; other site 292563008497 putative active site [active] 292563008498 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 292563008499 active site 292563008500 NTP binding site [chemical binding]; other site 292563008501 metal binding triad [ion binding]; metal-binding site 292563008502 antibiotic binding site [chemical binding]; other site 292563008503 Uncharacterized conserved protein [Function unknown]; Region: COG2361 292563008504 GTP-binding protein LepA; Provisional; Region: PRK05433 292563008505 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 292563008506 G1 box; other site 292563008507 putative GEF interaction site [polypeptide binding]; other site 292563008508 GTP/Mg2+ binding site [chemical binding]; other site 292563008509 Switch I region; other site 292563008510 G2 box; other site 292563008511 G3 box; other site 292563008512 Switch II region; other site 292563008513 G4 box; other site 292563008514 G5 box; other site 292563008515 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 292563008516 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 292563008517 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 292563008518 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 292563008519 active site 292563008520 SAM binding site [chemical binding]; other site 292563008521 homodimer interface [polypeptide binding]; other site 292563008522 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 292563008523 Domain of unknown function DUF21; Region: DUF21; pfam01595 292563008524 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 292563008525 Transporter associated domain; Region: CorC_HlyC; smart01091 292563008526 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 292563008527 putative active site [active] 292563008528 Uncharacterized conserved protein [Function unknown]; Region: COG2442 292563008529 Domain of unknown function DUF29; Region: DUF29; pfam01724 292563008530 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 292563008531 putative active site [active] 292563008532 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 292563008533 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 292563008534 TPR repeat; Region: TPR_11; pfam13414 292563008535 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563008536 binding surface 292563008537 TPR motif; other site 292563008538 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 292563008539 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 292563008540 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 292563008541 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 292563008542 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 292563008543 putative active site [active] 292563008544 Protein of unknown function DUF104; Region: DUF104; cl11530 292563008545 Protein of unknown function (DUF497); Region: DUF497; pfam04365 292563008546 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 292563008547 Part of AAA domain; Region: AAA_19; pfam13245 292563008548 Family description; Region: UvrD_C_2; pfam13538 292563008549 Caspase domain; Region: Peptidase_C14; pfam00656 292563008550 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 292563008551 Protein of unknown function (DUF3285); Region: DUF3285; pfam11688 292563008552 S-layer homology domain; Region: SLH; pfam00395 292563008553 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 292563008554 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 292563008555 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 292563008556 putative metal binding site; other site 292563008557 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 292563008558 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 292563008559 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 292563008560 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 292563008561 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 292563008562 putative dimer interface [polypeptide binding]; other site 292563008563 active site pocket [active] 292563008564 putative cataytic base [active] 292563008565 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 292563008566 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563008567 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563008568 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 292563008569 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563008570 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563008571 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 292563008572 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292563008573 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 292563008574 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 292563008575 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 292563008576 active site 292563008577 dimer interface [polypeptide binding]; other site 292563008578 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 292563008579 dimer interface [polypeptide binding]; other site 292563008580 active site 292563008581 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 292563008582 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 292563008583 active site 292563008584 substrate binding site [chemical binding]; other site 292563008585 trimer interface [polypeptide binding]; other site 292563008586 CoA binding site [chemical binding]; other site 292563008587 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 292563008588 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 292563008589 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 292563008590 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 292563008591 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 292563008592 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 292563008593 metal binding site [ion binding]; metal-binding site 292563008594 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 292563008595 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 292563008596 PBP superfamily domain; Region: PBP_like_2; cl17296 292563008597 PBP superfamily domain; Region: PBP_like_2; cl17296 292563008598 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 292563008599 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 292563008600 dimer interface [polypeptide binding]; other site 292563008601 conserved gate region; other site 292563008602 putative PBP binding loops; other site 292563008603 ABC-ATPase subunit interface; other site 292563008604 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 292563008605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 292563008606 dimer interface [polypeptide binding]; other site 292563008607 conserved gate region; other site 292563008608 putative PBP binding loops; other site 292563008609 ABC-ATPase subunit interface; other site 292563008610 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 292563008611 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 292563008612 Walker A/P-loop; other site 292563008613 ATP binding site [chemical binding]; other site 292563008614 Q-loop/lid; other site 292563008615 ABC transporter signature motif; other site 292563008616 Walker B; other site 292563008617 D-loop; other site 292563008618 H-loop/switch region; other site 292563008619 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 292563008620 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 292563008621 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 292563008622 protein binding site [polypeptide binding]; other site 292563008623 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 292563008624 Catalytic dyad [active] 292563008625 MEKHLA domain; Region: MEKHLA; pfam08670 292563008626 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 292563008627 putative active site [active] 292563008628 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 292563008629 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 292563008630 putative acyl-acceptor binding pocket; other site 292563008631 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 292563008632 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 292563008633 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 292563008634 acyl-activating enzyme (AAE) consensus motif; other site 292563008635 putative AMP binding site [chemical binding]; other site 292563008636 putative active site [active] 292563008637 putative CoA binding site [chemical binding]; other site 292563008638 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 292563008639 putative active site [active] 292563008640 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 292563008641 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 292563008642 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 292563008643 active site 292563008644 SAM binding site [chemical binding]; other site 292563008645 homodimer interface [polypeptide binding]; other site 292563008646 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 292563008647 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 292563008648 substrate binding pocket [chemical binding]; other site 292563008649 membrane-bound complex binding site; other site 292563008650 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292563008651 PAS fold; Region: PAS_3; pfam08447 292563008652 putative active site [active] 292563008653 heme pocket [chemical binding]; other site 292563008654 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 292563008655 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 292563008656 metal binding site [ion binding]; metal-binding site 292563008657 active site 292563008658 I-site; other site 292563008659 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 292563008660 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333 292563008661 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 292563008662 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 292563008663 FeS/SAM binding site; other site 292563008664 TRAM domain; Region: TRAM; pfam01938 292563008665 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 292563008666 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 292563008667 SelR domain; Region: SelR; pfam01641 292563008668 Protein of unknown function; Region: DUF3971; pfam13116 292563008669 Family of unknown function (DUF490); Region: DUF490; pfam04357 292563008670 Baculovirus gp64 envelope glycoprotein family; Region: Baculo_gp64; pfam03273 292563008671 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 292563008672 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 292563008673 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 292563008674 Predicted transcriptional regulator [Transcription]; Region: COG2378 292563008675 HTH domain; Region: HTH_11; cl17392 292563008676 WYL domain; Region: WYL; pfam13280 292563008677 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl09782 292563008678 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 292563008679 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 292563008680 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 292563008681 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 292563008682 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 292563008683 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 292563008684 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 292563008685 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 292563008686 GTP/Mg2+ binding site [chemical binding]; other site 292563008687 G4 box; other site 292563008688 G5 box; other site 292563008689 G1 box; other site 292563008690 Switch I region; other site 292563008691 G2 box; other site 292563008692 G3 box; other site 292563008693 Switch II region; other site 292563008694 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 292563008695 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 292563008696 motif II; other site 292563008697 Photosystem II reaction centre N protein (psbN); Region: PsbN; pfam02468 292563008698 Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977 292563008699 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 292563008700 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 292563008701 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292563008702 catalytic residue [active] 292563008703 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 292563008704 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 292563008705 active site residue [active] 292563008706 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 292563008707 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 292563008708 Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617 292563008709 Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321 292563008710 DNA gyrase subunit A; Validated; Region: PRK05560 292563008711 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 292563008712 CAP-like domain; other site 292563008713 active site 292563008714 primary dimer interface [polypeptide binding]; other site 292563008715 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 292563008716 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 292563008717 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 292563008718 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 292563008719 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 292563008720 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 292563008721 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 292563008722 active site 292563008723 putative DNA-binding cleft [nucleotide binding]; other site 292563008724 dimer interface [polypeptide binding]; other site 292563008725 FtsH Extracellular; Region: FtsH_ext; pfam06480 292563008726 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 292563008727 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 292563008728 Walker A motif; other site 292563008729 ATP binding site [chemical binding]; other site 292563008730 Walker B motif; other site 292563008731 arginine finger; other site 292563008732 Peptidase family M41; Region: Peptidase_M41; pfam01434 292563008733 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 292563008734 Probable transposase; Region: OrfB_IS605; pfam01385 292563008735 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 292563008736 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 292563008737 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 292563008738 minor groove reading motif; other site 292563008739 helix-hairpin-helix signature motif; other site 292563008740 substrate binding pocket [chemical binding]; other site 292563008741 active site 292563008742 light-harvesting-like protein 3; Provisional; Region: PLN00014 292563008743 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 292563008744 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292563008745 S-adenosylmethionine binding site [chemical binding]; other site 292563008746 XisH protein; Region: XisH; pfam08814 292563008747 XisI protein; Region: XisI; pfam08869 292563008748 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 292563008749 Resolvase, N terminal domain; Region: Resolvase; smart00857 292563008750 catalytic residues [active] 292563008751 Recombinase; Region: Recombinase; pfam07508 292563008752 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 292563008753 Sm and related proteins; Region: Sm_like; cl00259 292563008754 heptamer interface [polypeptide binding]; other site 292563008755 Sm1 motif; other site 292563008756 hexamer interface [polypeptide binding]; other site 292563008757 RNA binding site [nucleotide binding]; other site 292563008758 Sm2 motif; other site 292563008759 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 292563008760 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 292563008761 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 292563008762 Bifunctional nuclease; Region: DNase-RNase; pfam02577 292563008763 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 292563008764 Amidohydrolase; Region: Amidohydro_4; pfam13147 292563008765 active site 292563008766 dimer interface [polypeptide binding]; other site 292563008767 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 292563008768 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 292563008769 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 292563008770 phosphoenolpyruvate synthase; Validated; Region: PRK06241 292563008771 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 292563008772 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 292563008773 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 292563008774 Sulfate transporter family; Region: Sulfate_transp; pfam00916 292563008775 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 292563008776 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 292563008777 active site 292563008778 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 292563008779 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 292563008780 active site 292563008781 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 292563008782 K-Cl cotransporter; Region: 2a30; TIGR00930 292563008783 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 292563008784 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 292563008785 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 292563008786 Probable transposase; Region: OrfB_IS605; pfam01385 292563008787 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 292563008788 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 292563008789 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 292563008790 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 292563008791 Walker A/P-loop; other site 292563008792 ATP binding site [chemical binding]; other site 292563008793 Q-loop/lid; other site 292563008794 ABC transporter signature motif; other site 292563008795 Walker B; other site 292563008796 D-loop; other site 292563008797 H-loop/switch region; other site 292563008798 GTPase CgtA; Reviewed; Region: obgE; PRK12299 292563008799 GTP1/OBG; Region: GTP1_OBG; pfam01018 292563008800 Obg GTPase; Region: Obg; cd01898 292563008801 G1 box; other site 292563008802 GTP/Mg2+ binding site [chemical binding]; other site 292563008803 Switch I region; other site 292563008804 G2 box; other site 292563008805 G3 box; other site 292563008806 Switch II region; other site 292563008807 G4 box; other site 292563008808 G5 box; other site 292563008809 amidophosphoribosyltransferase; Provisional; Region: PRK07349 292563008810 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 292563008811 active site 292563008812 tetramer interface [polypeptide binding]; other site 292563008813 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 292563008814 active site 292563008815 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 292563008816 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 292563008817 ligand binding site [chemical binding]; other site 292563008818 flexible hinge region; other site 292563008819 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 292563008820 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 292563008821 catalytic core [active] 292563008822 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 292563008823 catalytic core [active] 292563008824 ABC-2 type transporter; Region: ABC2_membrane; cl17235 292563008825 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 292563008826 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 292563008827 Uncharacterized conserved protein [Function unknown]; Region: COG5464 292563008828 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 292563008829 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 292563008830 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 292563008831 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 292563008832 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 292563008833 TPR repeat; Region: TPR_11; pfam13414 292563008834 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 292563008835 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 292563008836 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292563008837 Walker A/P-loop; other site 292563008838 ATP binding site [chemical binding]; other site 292563008839 Q-loop/lid; other site 292563008840 ABC transporter signature motif; other site 292563008841 Walker B; other site 292563008842 D-loop; other site 292563008843 H-loop/switch region; other site 292563008844 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 292563008845 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292563008846 binding surface 292563008847 TPR motif; other site 292563008848 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 292563008849 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 292563008850 N-acetyl-D-glucosamine binding site [chemical binding]; other site 292563008851 catalytic residue [active] 292563008852 Ycf46; Provisional; Region: ycf46; CHL00195 292563008853 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 292563008854 Walker A motif; other site 292563008855 ATP binding site [chemical binding]; other site 292563008856 Walker B motif; other site 292563008857 arginine finger; other site 292563008858 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 292563008859 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 292563008860 Walker A motif; other site 292563008861 ATP binding site [chemical binding]; other site 292563008862 Walker B motif; other site 292563008863 arginine finger; other site 292563008864 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 292563008865 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 292563008866 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 292563008867 putative dimer interface [polypeptide binding]; other site 292563008868 C factor cell-cell signaling protein; Provisional; Region: PRK09009 292563008869 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 292563008870 NADP binding site [chemical binding]; other site 292563008871 homodimer interface [polypeptide binding]; other site 292563008872 active site 292563008873 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 292563008874 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 292563008875 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 292563008876 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 292563008877 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 292563008878 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 292563008879 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 292563008880 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 292563008881 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 292563008882 N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796 292563008883 putative active site [active] 292563008884 catalytic site [active] 292563008885 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 292563008886 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 292563008887 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 292563008888 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 292563008889 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 292563008890 trigger factor; Provisional; Region: tig; PRK01490 292563008891 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 292563008892 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 292563008893 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 292563008894 active site 292563008895 Uncharacterized conserved protein [Function unknown]; Region: COG1434 292563008896 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 292563008897 putative active site [active] 292563008898 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 292563008899 homodimer interface [polypeptide binding]; other site 292563008900 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 292563008901 active site pocket [active] 292563008902 hypothetical protein; Provisional; Region: PRK02509 292563008903 Uncharacterized conserved protein [Function unknown]; Region: COG1615 292563008904 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 292563008905 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292563008906 active site 292563008907 phosphorylation site [posttranslational modification] 292563008908 intermolecular recognition site; other site 292563008909 dimerization interface [polypeptide binding]; other site 292563008910 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 292563008911 DNA binding site [nucleotide binding] 292563008912 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 292563008913 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 292563008914 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 292563008915 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705 292563008916 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 292563008917 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 292563008918 RDD family; Region: RDD; pfam06271 292563008919 cytochrome c6; Provisional; Region: PRK13697 292563008920 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 292563008921 phosphoenolpyruvate synthase; Validated; Region: PRK06464 292563008922 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 292563008923 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 292563008924 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 292563008925 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 292563008926 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 292563008927 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 292563008928 diiron binding motif [ion binding]; other site 292563008929 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 292563008930 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 292563008931 2-isopropylmalate synthase; Validated; Region: PRK00915 292563008932 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 292563008933 active site 292563008934 catalytic residues [active] 292563008935 metal binding site [ion binding]; metal-binding site 292563008936 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 292563008937 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 292563008938 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 292563008939 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 292563008940 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 292563008941 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 292563008942 putative NAD(P) binding site [chemical binding]; other site 292563008943 active site 292563008944 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 292563008945 tetramerization interface [polypeptide binding]; other site 292563008946 active site 292563008947 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 292563008948 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 292563008949 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 292563008950 catalytic residue [active] 292563008951 proline aminopeptidase P II; Provisional; Region: PRK10879 292563008952 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 292563008953 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 292563008954 active site 292563008955 glutamine synthetase, type I; Region: GlnA; TIGR00653 292563008956 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 292563008957 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 292563008958 dephospho-CoA kinase; Region: TIGR00152 292563008959 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 292563008960 CoA-binding site [chemical binding]; other site 292563008961 ATP-binding [chemical binding]; other site