-- dump date 20140619_054453 -- class Genbank::misc_feature -- table misc_feature_note -- id note 292564000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 292564000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 292564000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 292564000004 Walker A motif; other site 292564000005 ATP binding site [chemical binding]; other site 292564000006 Walker B motif; other site 292564000007 arginine finger; other site 292564000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 292564000009 DnaA box-binding interface [nucleotide binding]; other site 292564000010 probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880 292564000011 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 292564000012 Walker A motif; other site 292564000013 ATP binding site [chemical binding]; other site 292564000014 Walker B motif; other site 292564000015 arginine finger; other site 292564000016 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 292564000017 DCoH dimer interaction site [polypeptide binding]; other site 292564000018 aromatic arch; other site 292564000019 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 292564000020 DCoH tetramer interaction site [polypeptide binding]; other site 292564000021 substrate binding site [chemical binding]; other site 292564000022 CO2 hydration protein (ChpXY); Region: ChpXY; pfam10216 292564000023 NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473 292564000024 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 292564000025 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 292564000026 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 292564000027 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 292564000028 Ferritin-like domain; Region: Ferritin; pfam00210 292564000029 dinuclear metal binding motif [ion binding]; other site 292564000030 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 292564000031 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 292564000032 Hexamer interface [polypeptide binding]; other site 292564000033 Hexagonal pore residue; other site 292564000034 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 292564000035 Hexamer/Pentamer interface [polypeptide binding]; other site 292564000036 central pore; other site 292564000037 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 292564000038 Hexamer/Pentamer interface [polypeptide binding]; other site 292564000039 central pore; other site 292564000040 Carboxysome Shell Carbonic Anhydrase; Region: CsoSCA; pfam08936 292564000041 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 292564000042 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 292564000043 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 292564000044 multimerization interface [polypeptide binding]; other site 292564000045 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 292564000046 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 292564000047 dimer interface [polypeptide binding]; other site 292564000048 catalytic residue [active] 292564000049 metal binding site [ion binding]; metal-binding site 292564000050 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 292564000051 Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058 292564000052 Hexamer interface [polypeptide binding]; other site 292564000053 Hexagonal pore residue; other site 292564000054 Hexagonal pore; other site 292564000055 Domain of unknown function (DUF897); Region: DUF897; pfam05982 292564000056 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 292564000057 active site 292564000058 dimerization interface [polypeptide binding]; other site 292564000059 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 292564000060 putative hexamer interface [polypeptide binding]; other site 292564000061 putative hexagonal pore; other site 292564000062 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052 292564000063 putative hexamer interface [polypeptide binding]; other site 292564000064 putative hexagonal pore; other site 292564000065 light-independent protochlorophyllide reductase subunit N; Provisional; Region: PRK02842 292564000066 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 292564000067 light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910 292564000068 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 292564000069 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 292564000070 protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185 292564000071 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 292564000072 P-loop; other site 292564000073 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 292564000074 protochlorophyllide oxidoreductase; Validated; Region: PRK07453 292564000075 NAD(P) binding site [chemical binding]; other site 292564000076 active site 292564000077 photosystem I reaction center subunit XII; Reviewed; Region: psaM; PRK11878 292564000078 Domain of unknown function (DUF1817); Region: DUF1817; pfam08847 292564000079 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 292564000080 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 292564000081 active site 292564000082 Peptidase family M50; Region: Peptidase_M50; pfam02163 292564000083 putative substrate binding region [chemical binding]; other site 292564000084 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 292564000085 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 292564000086 active site 292564000087 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 292564000088 GTP cyclohydrolase I; Provisional; Region: PLN03044 292564000089 active site 292564000090 short chain dehydrogenase; Provisional; Region: PRK07454 292564000091 classical (c) SDRs; Region: SDR_c; cd05233 292564000092 NAD(P) binding site [chemical binding]; other site 292564000093 active site 292564000094 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 292564000095 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 292564000096 acyl-ACP reductase; Provisional; Region: PRK14982 292564000097 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 292564000098 NAD(P) binding pocket [chemical binding]; other site 292564000099 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 292564000100 dinuclear metal binding motif [ion binding]; other site 292564000101 Creatinine amidohydrolase; Region: Creatininase; pfam02633 292564000102 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 292564000103 RNA binding site [nucleotide binding]; other site 292564000104 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 292564000105 RNA binding site [nucleotide binding]; other site 292564000106 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 292564000107 RNA binding site [nucleotide binding]; other site 292564000108 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 292564000109 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 292564000110 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 292564000111 phosphoenolpyruvate synthase; Validated; Region: PRK06464 292564000112 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 292564000113 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 292564000114 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 292564000115 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 292564000116 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 292564000117 PYR/PP interface [polypeptide binding]; other site 292564000118 dimer interface [polypeptide binding]; other site 292564000119 TPP binding site [chemical binding]; other site 292564000120 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 292564000121 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 292564000122 TPP-binding site [chemical binding]; other site 292564000123 dimer interface [polypeptide binding]; other site 292564000124 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 292564000125 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 292564000126 Peptidase family M23; Region: Peptidase_M23; pfam01551 292564000127 ferrochelatase; Reviewed; Region: hemH; PRK00035 292564000128 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 292564000129 C-terminal domain interface [polypeptide binding]; other site 292564000130 active site 292564000131 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 292564000132 active site 292564000133 N-terminal domain interface [polypeptide binding]; other site 292564000134 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 292564000135 active site 292564000136 catalytic residues [active] 292564000137 DNA binding site [nucleotide binding] 292564000138 Int/Topo IB signature motif; other site 292564000139 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 292564000140 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 292564000141 homodimer interface [polypeptide binding]; other site 292564000142 Walker A motif; other site 292564000143 ATP binding site [chemical binding]; other site 292564000144 hydroxycobalamin binding site [chemical binding]; other site 292564000145 Walker B motif; other site 292564000146 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 292564000147 putative nucleotide binding site [chemical binding]; other site 292564000148 uridine monophosphate binding site [chemical binding]; other site 292564000149 homohexameric interface [polypeptide binding]; other site 292564000150 ribosome recycling factor; Reviewed; Region: frr; PRK00083 292564000151 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 292564000152 hinge region; other site 292564000153 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 292564000154 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 292564000155 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 292564000156 ligand binding site [chemical binding]; other site 292564000157 flexible hinge region; other site 292564000158 transaldolase/EF-hand domain-containing protein; Provisional; Region: PRK12309 292564000159 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 292564000160 active site 292564000161 dimer interface [polypeptide binding]; other site 292564000162 catalytic residue [active] 292564000163 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 292564000164 Ca2+ binding site [ion binding]; other site 292564000165 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 292564000166 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 292564000167 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 292564000168 CAAX protease self-immunity; Region: Abi; pfam02517 292564000169 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 292564000170 catalytic core [active] 292564000171 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 292564000172 catalytic core [active] 292564000173 dihydroorotase; Provisional; Region: PRK07369 292564000174 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 292564000175 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 292564000176 active site 292564000177 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 292564000178 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 292564000179 Catalytic site [active] 292564000180 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 292564000181 ArsC family; Region: ArsC; pfam03960 292564000182 putative ArsC-like catalytic residues; other site 292564000183 putative TRX-like catalytic residues [active] 292564000184 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 292564000185 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 292564000186 catalytic loop [active] 292564000187 iron binding site [ion binding]; other site 292564000188 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292564000189 S-adenosylmethionine binding site [chemical binding]; other site 292564000190 prolyl-tRNA synthetase; Provisional; Region: PRK09194 292564000191 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 292564000192 dimer interface [polypeptide binding]; other site 292564000193 motif 1; other site 292564000194 active site 292564000195 motif 2; other site 292564000196 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 292564000197 putative deacylase active site [active] 292564000198 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 292564000199 active site 292564000200 motif 3; other site 292564000201 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 292564000202 anticodon binding site; other site 292564000203 photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044 292564000204 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 292564000205 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 292564000206 GDP-binding site [chemical binding]; other site 292564000207 ACT binding site; other site 292564000208 IMP binding site; other site 292564000209 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 292564000210 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 292564000211 substrate binding site [chemical binding]; other site 292564000212 ATP binding site [chemical binding]; other site 292564000213 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 292564000214 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 292564000215 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 292564000216 ssDNA binding site [nucleotide binding]; other site 292564000217 dimer interface [polypeptide binding]; other site 292564000218 tetramer (dimer of dimers) interface [polypeptide binding]; other site 292564000219 Protein of unknown function (DUF2854); Region: DUF2854; pfam11016 292564000220 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 292564000221 feedback inhibition sensing region; other site 292564000222 homohexameric interface [polypeptide binding]; other site 292564000223 nucleotide binding site [chemical binding]; other site 292564000224 N-acetyl-L-glutamate binding site [chemical binding]; other site 292564000225 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 292564000226 primosome assembly protein PriA; Validated; Region: PRK05580 292564000227 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 292564000228 ATP binding site [chemical binding]; other site 292564000229 putative Mg++ binding site [ion binding]; other site 292564000230 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 292564000231 RNA polymerase sigma factor RpoD; Validated; Region: PRK07406 292564000232 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 292564000233 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 292564000234 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 292564000235 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 292564000236 DNA binding residues [nucleotide binding] 292564000237 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 292564000238 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 292564000239 Ligand binding site; other site 292564000240 Putative Catalytic site; other site 292564000241 DXD motif; other site 292564000242 Predicted membrane protein [Function unknown]; Region: COG2246 292564000243 GtrA-like protein; Region: GtrA; pfam04138 292564000244 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 292564000245 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 292564000246 active site 292564000247 Domain of unknown function (DUF1824); Region: DUF1824; pfam08854 292564000248 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 292564000249 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 292564000250 domain interfaces; other site 292564000251 active site 292564000252 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 292564000253 Cl- selectivity filter; other site 292564000254 Cl- binding residues [ion binding]; other site 292564000255 pore gating glutamate residue; other site 292564000256 dimer interface [polypeptide binding]; other site 292564000257 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 292564000258 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 292564000259 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 292564000260 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 292564000261 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 292564000262 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 292564000263 dimer interface [polypeptide binding]; other site 292564000264 substrate binding site [chemical binding]; other site 292564000265 metal binding sites [ion binding]; metal-binding site 292564000266 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 292564000267 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 292564000268 Zn binding site [ion binding]; other site 292564000269 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 292564000270 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 292564000271 putative active site [active] 292564000272 OsmC-like protein; Region: OsmC; pfam02566 292564000273 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 292564000274 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 292564000275 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 292564000276 CEO family (DUF1632); Region: DUF1632; pfam07857 292564000277 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 292564000278 Fatty acid desaturase; Region: FA_desaturase; pfam00487 292564000279 putative di-iron ligands [ion binding]; other site 292564000280 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 292564000281 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 292564000282 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 292564000283 aromatic arch; other site 292564000284 DCoH dimer interaction site [polypeptide binding]; other site 292564000285 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 292564000286 DCoH tetramer interaction site [polypeptide binding]; other site 292564000287 substrate binding site [chemical binding]; other site 292564000288 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 292564000289 putative active site [active] 292564000290 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 292564000291 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 292564000292 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 292564000293 nudix motif; other site 292564000294 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 292564000295 Clp amino terminal domain; Region: Clp_N; pfam02861 292564000296 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 292564000297 Walker A motif; other site 292564000298 ATP binding site [chemical binding]; other site 292564000299 Walker B motif; other site 292564000300 arginine finger; other site 292564000301 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 292564000302 Walker A motif; other site 292564000303 ATP binding site [chemical binding]; other site 292564000304 Walker B motif; other site 292564000305 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 292564000306 Cytochrome c; Region: Cytochrom_C; cl11414 292564000307 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 292564000308 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 292564000309 NAD(P) binding site [chemical binding]; other site 292564000310 active site 292564000311 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 292564000312 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 292564000313 substrate binding site [chemical binding]; other site 292564000314 active site 292564000315 glycogen branching enzyme; Provisional; Region: PRK05402 292564000316 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 292564000317 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 292564000318 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 292564000319 active site 292564000320 catalytic site [active] 292564000321 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 292564000322 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 292564000323 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 292564000324 Integrase core domain; Region: rve; pfam00665 292564000325 Integrase core domain; Region: rve; pfam00665 292564000326 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 292564000327 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 292564000328 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 292564000329 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 292564000330 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 292564000331 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 292564000332 Transposase domain (DUF772); Region: DUF772; pfam05598 292564000333 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 292564000334 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 292564000335 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 292564000336 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 292564000337 Protein of function (DUF2518); Region: DUF2518; pfam10726 292564000338 Family of unknown function (DUF490); Region: DUF490; pfam04357 292564000339 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 292564000340 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 292564000341 nucleotide binding site [chemical binding]; other site 292564000342 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 292564000343 putative catalytic cysteine [active] 292564000344 Dihydroneopterin aldolase; Region: FolB; pfam02152 292564000345 active site 292564000346 amino acid transporter; Region: 2A0306; TIGR00909 292564000347 cationic amino acid transport permease; Region: 2A0303; TIGR00906 292564000348 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 292564000349 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 292564000350 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 292564000351 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 292564000352 aromatic arch; other site 292564000353 DCoH dimer interaction site [polypeptide binding]; other site 292564000354 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 292564000355 DCoH tetramer interaction site [polypeptide binding]; other site 292564000356 substrate binding site [chemical binding]; other site 292564000357 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 292564000358 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 292564000359 Staphylococcal nuclease homologues; Region: SNc; smart00318 292564000360 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 292564000361 Catalytic site; other site 292564000362 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 292564000363 methionine sulfoxide reductase A; Provisional; Region: PRK13014 292564000364 Transposase; Region: HTH_Tnp_1; cl17663 292564000365 Integrase core domain; Region: rve; pfam00665 292564000366 DDE domain; Region: DDE_Tnp_IS240; pfam13610 292564000367 Integrase core domain; Region: rve_3; pfam13683 292564000368 Transposase; Region: HTH_Tnp_1; cl17663 292564000369 Winged helix-turn helix; Region: HTH_29; pfam13551 292564000370 Homeodomain-like domain; Region: HTH_32; pfam13565 292564000371 Integrase core domain; Region: rve; pfam00665 292564000372 Integrase core domain; Region: rve_3; pfam13683 292564000373 Transposase; Region: HTH_Tnp_1; pfam01527 292564000374 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 292564000375 putative transposase OrfB; Reviewed; Region: PHA02517 292564000376 HTH-like domain; Region: HTH_21; pfam13276 292564000377 Integrase core domain; Region: rve; pfam00665 292564000378 Integrase core domain; Region: rve_3; pfam13683 292564000379 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 292564000380 Domain of unknown function (DUF932); Region: DUF932; cl12129 292564000381 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 292564000382 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 292564000383 generic binding surface II; other site 292564000384 AAA domain; Region: AAA_25; pfam13481 292564000385 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 292564000386 Walker A motif; other site 292564000387 ATP binding site [chemical binding]; other site 292564000388 Walker B motif; other site 292564000389 Transposase; Region: HTH_Tnp_1; cl17663 292564000390 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 292564000391 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 292564000392 active site 292564000393 catalytic residues [active] 292564000394 DNA binding site [nucleotide binding] 292564000395 Int/Topo IB signature motif; other site 292564000396 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 292564000397 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 292564000398 Cytochrome P450; Region: p450; cl12078 292564000399 hypothetical protein; Provisional; Region: PRK07877 292564000400 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 292564000401 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292564000402 Walker A/P-loop; other site 292564000403 ATP binding site [chemical binding]; other site 292564000404 Q-loop/lid; other site 292564000405 ABC transporter signature motif; other site 292564000406 Walker B; other site 292564000407 D-loop; other site 292564000408 H-loop/switch region; other site 292564000409 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 292564000410 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 292564000411 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 292564000412 putative dimer interface [polypeptide binding]; other site 292564000413 N-terminal domain interface [polypeptide binding]; other site 292564000414 putative substrate binding pocket (H-site) [chemical binding]; other site 292564000415 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 292564000416 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 292564000417 light-harvesting-like protein 3; Provisional; Region: PLN00014 292564000418 light-harvesting-like protein 3; Provisional; Region: PLN00014 292564000419 SnoaL-like domain; Region: SnoaL_2; pfam12680 292564000420 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 292564000421 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 292564000422 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 292564000423 oligomer interface [polypeptide binding]; other site 292564000424 metal binding site [ion binding]; metal-binding site 292564000425 metal binding site [ion binding]; metal-binding site 292564000426 putative Cl binding site [ion binding]; other site 292564000427 aspartate ring; other site 292564000428 basic sphincter; other site 292564000429 hydrophobic gate; other site 292564000430 periplasmic entrance; other site 292564000431 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 292564000432 glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511 292564000433 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 292564000434 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 292564000435 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 292564000436 C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196 292564000437 putative N-terminal domain interface [polypeptide binding]; other site 292564000438 putative dimer interface [polypeptide binding]; other site 292564000439 putative substrate binding pocket (H-site) [chemical binding]; other site 292564000440 Protein of unknown function (DUF952); Region: DUF952; pfam06108 292564000441 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 292564000442 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 292564000443 active site residue [active] 292564000444 biotin synthase; Region: bioB; TIGR00433 292564000445 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 292564000446 FeS/SAM binding site; other site 292564000447 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 292564000448 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 292564000449 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 292564000450 catalytic residue [active] 292564000451 putative FPP diphosphate binding site; other site 292564000452 putative FPP binding hydrophobic cleft; other site 292564000453 dimer interface [polypeptide binding]; other site 292564000454 putative IPP diphosphate binding site; other site 292564000455 TIGR00159 family protein; Region: TIGR00159 292564000456 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 292564000457 diaminopimelate decarboxylase; Region: lysA; TIGR01048 292564000458 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 292564000459 active site 292564000460 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 292564000461 substrate binding site [chemical binding]; other site 292564000462 catalytic residues [active] 292564000463 dimer interface [polypeptide binding]; other site 292564000464 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 292564000465 Clp protease ATP binding subunit; Region: clpC; CHL00095 292564000466 Clp amino terminal domain; Region: Clp_N; pfam02861 292564000467 Clp amino terminal domain; Region: Clp_N; pfam02861 292564000468 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 292564000469 Walker A motif; other site 292564000470 ATP binding site [chemical binding]; other site 292564000471 Walker B motif; other site 292564000472 arginine finger; other site 292564000473 UvrB/uvrC motif; Region: UVR; pfam02151 292564000474 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 292564000475 Walker A motif; other site 292564000476 ATP binding site [chemical binding]; other site 292564000477 Walker B motif; other site 292564000478 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 292564000479 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 292564000480 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 292564000481 active site 292564000482 NAD binding site [chemical binding]; other site 292564000483 metal binding site [ion binding]; metal-binding site 292564000484 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 292564000485 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 292564000486 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 292564000487 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 292564000488 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 292564000489 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292564000490 S-adenosylmethionine binding site [chemical binding]; other site 292564000491 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 292564000492 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 292564000493 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 292564000494 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 292564000495 ABC1 family; Region: ABC1; cl17513 292564000496 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 292564000497 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 292564000498 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 292564000499 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 292564000500 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 292564000501 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 292564000502 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 292564000503 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 292564000504 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 292564000505 RNA binding surface [nucleotide binding]; other site 292564000506 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 292564000507 active site 292564000508 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 292564000509 non-specific DNA binding site [nucleotide binding]; other site 292564000510 salt bridge; other site 292564000511 sequence-specific DNA binding site [nucleotide binding]; other site 292564000512 4-alpha-glucanotransferase; Provisional; Region: PRK14508 292564000513 Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035 292564000514 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 292564000515 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 292564000516 Transcriptional regulator [Transcription]; Region: LytR; COG1316 292564000517 AAA domain; Region: AAA_33; pfam13671 292564000518 WYL domain; Region: WYL; pfam13280 292564000519 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 292564000520 putative active site [active] 292564000521 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 292564000522 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 292564000523 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 292564000524 ATP binding site [chemical binding]; other site 292564000525 putative Mg++ binding site [ion binding]; other site 292564000526 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 292564000527 nucleotide binding region [chemical binding]; other site 292564000528 ATP-binding site [chemical binding]; other site 292564000529 Uncharacterized conserved protein [Function unknown]; Region: COG1479 292564000530 Protein of unknown function DUF262; Region: DUF262; pfam03235 292564000531 Uncharacterized conserved protein [Function unknown]; Region: COG3472 292564000532 tellurium resistance terB-like protein; Region: terB_like; cd07177 292564000533 metal binding site [ion binding]; metal-binding site 292564000534 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 292564000535 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 292564000536 RES domain; Region: RES; smart00953 292564000537 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 292564000538 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 292564000539 ATP binding site [chemical binding]; other site 292564000540 putative Mg++ binding site [ion binding]; other site 292564000541 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 292564000542 ATP-binding site [chemical binding]; other site 292564000543 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 292564000544 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 292564000545 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 292564000546 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 292564000547 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 292564000548 putative active site [active] 292564000549 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812 292564000550 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 292564000551 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 292564000552 active site 292564000553 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 292564000554 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 292564000555 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292564000556 active site 292564000557 phosphorylation site [posttranslational modification] 292564000558 intermolecular recognition site; other site 292564000559 dimerization interface [polypeptide binding]; other site 292564000560 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 292564000561 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 292564000562 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 292564000563 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 292564000564 metal binding site [ion binding]; metal-binding site 292564000565 active site 292564000566 I-site; other site 292564000567 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 292564000568 Response regulator receiver domain; Region: Response_reg; pfam00072 292564000569 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292564000570 active site 292564000571 phosphorylation site [posttranslational modification] 292564000572 intermolecular recognition site; other site 292564000573 dimerization interface [polypeptide binding]; other site 292564000574 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292564000575 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 292564000576 putative active site [active] 292564000577 heme pocket [chemical binding]; other site 292564000578 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292564000579 putative active site [active] 292564000580 heme pocket [chemical binding]; other site 292564000581 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 292564000582 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292564000583 putative active site [active] 292564000584 heme pocket [chemical binding]; other site 292564000585 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 292564000586 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 292564000587 PAS fold; Region: PAS_4; pfam08448 292564000588 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292564000589 putative active site [active] 292564000590 heme pocket [chemical binding]; other site 292564000591 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292564000592 PAS domain; Region: PAS_9; pfam13426 292564000593 putative active site [active] 292564000594 heme pocket [chemical binding]; other site 292564000595 PAS domain S-box; Region: sensory_box; TIGR00229 292564000596 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 292564000597 GAF domain; Region: GAF; pfam01590 292564000598 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292564000599 dimer interface [polypeptide binding]; other site 292564000600 phosphorylation site [posttranslational modification] 292564000601 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292564000602 ATP binding site [chemical binding]; other site 292564000603 Mg2+ binding site [ion binding]; other site 292564000604 G-X-G motif; other site 292564000605 aminopeptidase N; Provisional; Region: pepN; PRK14015 292564000606 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 292564000607 Zn binding site [ion binding]; other site 292564000608 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 292564000609 Circadian oscillating protein COP23; Region: COP23; pfam14218 292564000610 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 292564000611 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 292564000612 FHA domain; Region: FHA; pfam00498 292564000613 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 292564000614 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 292564000615 phosphopeptide binding site; other site 292564000616 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 292564000617 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 292564000618 Walker A/P-loop; other site 292564000619 ATP binding site [chemical binding]; other site 292564000620 Q-loop/lid; other site 292564000621 ABC transporter signature motif; other site 292564000622 Walker B; other site 292564000623 D-loop; other site 292564000624 H-loop/switch region; other site 292564000625 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 292564000626 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 292564000627 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 292564000628 putative transposase OrfB; Reviewed; Region: PHA02517 292564000629 HTH-like domain; Region: HTH_21; pfam13276 292564000630 Integrase core domain; Region: rve; pfam00665 292564000631 Integrase core domain; Region: rve_3; pfam13683 292564000632 Transposase; Region: HTH_Tnp_1; cl17663 292564000633 Integrase core domain; Region: rve; pfam00665 292564000634 DDE domain; Region: DDE_Tnp_IS240; pfam13610 292564000635 Integrase core domain; Region: rve_3; pfam13683 292564000636 NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797 292564000637 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292564000638 Walker A/P-loop; other site 292564000639 ATP binding site [chemical binding]; other site 292564000640 Q-loop/lid; other site 292564000641 ABC transporter signature motif; other site 292564000642 Walker B; other site 292564000643 D-loop; other site 292564000644 H-loop/switch region; other site 292564000645 NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794 292564000646 HlyD family secretion protein; Region: HlyD_3; pfam13437 292564000647 NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796 292564000648 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 292564000649 putative active site [active] 292564000650 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 292564000651 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292564000652 Walker A/P-loop; other site 292564000653 ATP binding site [chemical binding]; other site 292564000654 Q-loop/lid; other site 292564000655 ABC transporter signature motif; other site 292564000656 Walker B; other site 292564000657 D-loop; other site 292564000658 H-loop/switch region; other site 292564000659 Integrase core domain; Region: rve; pfam00665 292564000660 Winged helix-turn helix; Region: HTH_29; pfam13551 292564000661 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 292564000662 Integrase core domain; Region: rve; pfam00665 292564000663 Integrase core domain; Region: rve_3; pfam13683 292564000664 Transposase; Region: HTH_Tnp_1; cl17663 292564000665 CHAT domain; Region: CHAT; cl17868 292564000666 Tetratricopeptide repeat; Region: TPR_12; pfam13424 292564000667 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292564000668 binding surface 292564000669 TPR motif; other site 292564000670 Tetratricopeptide repeat; Region: TPR_12; pfam13424 292564000671 Tetratricopeptide repeat; Region: TPR_12; pfam13424 292564000672 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292564000673 binding surface 292564000674 TPR motif; other site 292564000675 Tetratricopeptide repeat; Region: TPR_12; pfam13424 292564000676 Tetratricopeptide repeat; Region: TPR_10; pfam13374 292564000677 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292564000678 Tetratricopeptide repeat; Region: TPR_12; pfam13424 292564000679 binding surface 292564000680 TPR motif; other site 292564000681 CHAT domain; Region: CHAT; pfam12770 292564000682 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 292564000683 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 292564000684 active site 292564000685 metal binding site [ion binding]; metal-binding site 292564000686 Circadian oscillating protein COP23; Region: COP23; pfam14218 292564000687 adaptive-response sensory kinase; Validated; Region: PRK09303 292564000688 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 292564000689 tetramer interface [polypeptide binding]; other site 292564000690 dimer interface [polypeptide binding]; other site 292564000691 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292564000692 dimer interface [polypeptide binding]; other site 292564000693 phosphorylation site [posttranslational modification] 292564000694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292564000695 ATP binding site [chemical binding]; other site 292564000696 Mg2+ binding site [ion binding]; other site 292564000697 G-X-G motif; other site 292564000698 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_11; cd08866 292564000699 putative hydrophobic ligand binding site [chemical binding]; other site 292564000700 CpcD/allophycocyanin linker domain; Region: CpcD; smart01094 292564000701 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 292564000702 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 292564000703 dimerization interface [polypeptide binding]; other site 292564000704 FAD binding pocket [chemical binding]; other site 292564000705 FAD binding motif [chemical binding]; other site 292564000706 catalytic residues [active] 292564000707 NAD binding pocket [chemical binding]; other site 292564000708 phosphate binding motif [ion binding]; other site 292564000709 beta-alpha-beta structure motif; other site 292564000710 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 292564000711 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 292564000712 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 292564000713 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 292564000714 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 292564000715 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 292564000716 catalytic triad [active] 292564000717 Acylphosphatase; Region: Acylphosphatase; cl00551 292564000718 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 292564000719 AAA domain; Region: AAA_30; pfam13604 292564000720 Family description; Region: UvrD_C_2; pfam13538 292564000721 Divergent PAP2 family; Region: DUF212; pfam02681 292564000722 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 292564000723 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 292564000724 substrate binding pocket [chemical binding]; other site 292564000725 chain length determination region; other site 292564000726 substrate-Mg2+ binding site; other site 292564000727 catalytic residues [active] 292564000728 aspartate-rich region 1; other site 292564000729 active site lid residues [active] 292564000730 aspartate-rich region 2; other site 292564000731 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186 292564000732 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 292564000733 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 292564000734 homodimer interface [polypeptide binding]; other site 292564000735 NADP binding site [chemical binding]; other site 292564000736 substrate binding site [chemical binding]; other site 292564000737 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 292564000738 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 292564000739 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 292564000740 Zn2+ binding site [ion binding]; other site 292564000741 Mg2+ binding site [ion binding]; other site 292564000742 CrcB-like protein; Region: CRCB; pfam02537 292564000743 CrcB-like protein; Region: CRCB; pfam02537 292564000744 Uncharacterized conserved protein [Function unknown]; Region: COG4095 292564000745 ATP-grasp domain; Region: ATP-grasp_4; cl17255 292564000746 conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729 292564000747 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 292564000748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 292564000749 dimer interface [polypeptide binding]; other site 292564000750 conserved gate region; other site 292564000751 putative PBP binding loops; other site 292564000752 ABC-ATPase subunit interface; other site 292564000753 2-isopropylmalate synthase; Validated; Region: PRK00915 292564000754 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 292564000755 active site 292564000756 catalytic residues [active] 292564000757 metal binding site [ion binding]; metal-binding site 292564000758 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 292564000759 Uncharacterized conserved protein [Function unknown]; Region: COG1543 292564000760 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 292564000761 active site 292564000762 substrate binding site [chemical binding]; other site 292564000763 catalytic site [active] 292564000764 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 292564000765 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 292564000766 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 292564000767 Walker A/P-loop; other site 292564000768 ATP binding site [chemical binding]; other site 292564000769 Q-loop/lid; other site 292564000770 ABC transporter signature motif; other site 292564000771 Walker B; other site 292564000772 D-loop; other site 292564000773 H-loop/switch region; other site 292564000774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 292564000775 dimer interface [polypeptide binding]; other site 292564000776 conserved gate region; other site 292564000777 ABC-ATPase subunit interface; other site 292564000778 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 292564000779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 292564000780 ABC-ATPase subunit interface; other site 292564000781 Winged helix-turn helix; Region: HTH_29; pfam13551 292564000782 Homeodomain-like domain; Region: HTH_32; pfam13565 292564000783 Integrase core domain; Region: rve; pfam00665 292564000784 Integrase core domain; Region: rve_3; pfam13683 292564000785 Transposase; Region: HTH_Tnp_1; cl17663 292564000786 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 292564000787 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 292564000788 substrate binding pocket [chemical binding]; other site 292564000789 membrane-bound complex binding site; other site 292564000790 hinge residues; other site 292564000791 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 292564000792 Fasciclin domain; Region: Fasciclin; pfam02469 292564000793 CO2 hydration protein (ChpXY); Region: ChpXY; cl10905 292564000794 NAD(P)H-quinone oxidoreductase subunit M; Validated; Region: PRK07363 292564000795 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 292564000796 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 292564000797 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 292564000798 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 292564000799 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 292564000800 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 292564000801 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 292564000802 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 292564000803 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 292564000804 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 292564000805 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 292564000806 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 292564000807 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 292564000808 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 292564000809 transmembrane helices; other site 292564000810 TrkA-C domain; Region: TrkA_C; pfam02080 292564000811 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 292564000812 TrkA-C domain; Region: TrkA_C; pfam02080 292564000813 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 292564000814 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 292564000815 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 292564000816 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 292564000817 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 292564000818 putative active site [active] 292564000819 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_3; cd08653 292564000820 putative active site [active] 292564000821 putative cosubstrate binding site; other site 292564000822 putative substrate binding site [chemical binding]; other site 292564000823 catalytic site [active] 292564000824 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 292564000825 active site 292564000826 catalytic residues [active] 292564000827 metal binding site [ion binding]; metal-binding site 292564000828 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 292564000829 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 292564000830 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 292564000831 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 292564000832 active site 292564000833 substrate binding pocket [chemical binding]; other site 292564000834 dimer interface [polypeptide binding]; other site 292564000835 META domain; Region: META; pfam03724 292564000836 Uncharacterized conserved protein [Function unknown]; Region: COG0393 292564000837 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 292564000838 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 292564000839 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 292564000840 glycogen synthase; Provisional; Region: glgA; PRK00654 292564000841 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 292564000842 ADP-binding pocket [chemical binding]; other site 292564000843 homodimer interface [polypeptide binding]; other site 292564000844 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 292564000845 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 292564000846 GAF domain; Region: GAF; pfam01590 292564000847 GAF domain; Region: GAF_2; pfam13185 292564000848 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 292564000849 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 292564000850 active site 292564000851 I-site; other site 292564000852 metal binding site [ion binding]; metal-binding site 292564000853 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 292564000854 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 292564000855 ATP binding site [chemical binding]; other site 292564000856 Mg2+ binding site [ion binding]; other site 292564000857 G-X-G motif; other site 292564000858 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 292564000859 anti sigma factor interaction site; other site 292564000860 regulatory phosphorylation site [posttranslational modification]; other site 292564000861 Bacterial sugar transferase; Region: Bac_transf; pfam02397 292564000862 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 292564000863 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 292564000864 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 292564000865 active site 292564000866 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 292564000867 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 292564000868 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 292564000869 active site 292564000870 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 292564000871 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 292564000872 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 292564000873 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 292564000874 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 292564000875 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 292564000876 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 292564000877 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292564000878 putative active site [active] 292564000879 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 292564000880 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292564000881 dimer interface [polypeptide binding]; other site 292564000882 phosphorylation site [posttranslational modification] 292564000883 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292564000884 ATP binding site [chemical binding]; other site 292564000885 Mg2+ binding site [ion binding]; other site 292564000886 G-X-G motif; other site 292564000887 Response regulator receiver domain; Region: Response_reg; pfam00072 292564000888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292564000889 active site 292564000890 phosphorylation site [posttranslational modification] 292564000891 intermolecular recognition site; other site 292564000892 dimerization interface [polypeptide binding]; other site 292564000893 Response regulator receiver domain; Region: Response_reg; pfam00072 292564000894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292564000895 active site 292564000896 phosphorylation site [posttranslational modification] 292564000897 intermolecular recognition site; other site 292564000898 dimerization interface [polypeptide binding]; other site 292564000899 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 292564000900 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 292564000901 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 292564000902 anti sigma factor interaction site; other site 292564000903 regulatory phosphorylation site [posttranslational modification]; other site 292564000904 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 292564000905 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 292564000906 substrate binding site [chemical binding]; other site 292564000907 oxyanion hole (OAH) forming residues; other site 292564000908 trimer interface [polypeptide binding]; other site 292564000909 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 292564000910 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 292564000911 dimer interface [polypeptide binding]; other site 292564000912 tetramer interface [polypeptide binding]; other site 292564000913 PYR/PP interface [polypeptide binding]; other site 292564000914 TPP binding site [chemical binding]; other site 292564000915 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 292564000916 TPP-binding site [chemical binding]; other site 292564000917 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 292564000918 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 292564000919 Catalytic site [active] 292564000920 Protein of unknown function (DUF760); Region: DUF760; pfam05542 292564000921 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 292564000922 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 292564000923 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 292564000924 ABC-ATPase subunit interface; other site 292564000925 dimer interface [polypeptide binding]; other site 292564000926 putative PBP binding regions; other site 292564000927 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 292564000928 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 292564000929 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 292564000930 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 292564000931 metal binding site [ion binding]; metal-binding site 292564000932 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 292564000933 protein I interface; other site 292564000934 D2 interface; other site 292564000935 protein T interface; other site 292564000936 chlorophyll binding site; other site 292564000937 beta carotene binding site; other site 292564000938 pheophytin binding site; other site 292564000939 manganese-stabilizing polypeptide interface; other site 292564000940 CP43 interface; other site 292564000941 protein L interface; other site 292564000942 oxygen evolving complex binding site; other site 292564000943 bromide binding site; other site 292564000944 quinone binding site; other site 292564000945 Fe binding site [ion binding]; other site 292564000946 core light harvesting interface; other site 292564000947 cytochrome b559 alpha subunit interface; other site 292564000948 cytochrome c-550 interface; other site 292564000949 protein J interface; other site 292564000950 Domain of unknown function (DUF697); Region: DUF697; pfam05128 292564000951 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 292564000952 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 292564000953 active site 292564000954 HIGH motif; other site 292564000955 dimer interface [polypeptide binding]; other site 292564000956 KMSKS motif; other site 292564000957 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 292564000958 catalytic residue [active] 292564000959 TM2 domain; Region: TM2; cl00984 292564000960 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 292564000961 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 292564000962 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 292564000963 active site 292564000964 dimer interface [polypeptide binding]; other site 292564000965 motif 1; other site 292564000966 motif 2; other site 292564000967 motif 3; other site 292564000968 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 292564000969 anticodon binding site; other site 292564000970 Glucokinase; Region: Glucokinase; cl17310 292564000971 glucokinase, proteobacterial type; Region: glk; TIGR00749 292564000972 homoserine kinase; Provisional; Region: PRK01212 292564000973 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 292564000974 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 292564000975 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 292564000976 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 292564000977 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 292564000978 active site 292564000979 Zn binding site [ion binding]; other site 292564000980 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 292564000981 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 292564000982 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 292564000983 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 292564000984 putative substrate translocation pore; other site 292564000985 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 292564000986 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 292564000987 Uncharacterized conserved protein [Function unknown]; Region: COG0398 292564000988 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 292564000989 mercuric reductase; Validated; Region: PRK06370 292564000990 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 292564000991 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 292564000992 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 292564000993 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 292564000994 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 292564000995 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 292564000996 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 292564000997 Substrate binding site; other site 292564000998 Mg++ binding site; other site 292564000999 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 292564001000 active site 292564001001 substrate binding site [chemical binding]; other site 292564001002 CoA binding site [chemical binding]; other site 292564001003 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 292564001004 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 292564001005 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 292564001006 hinge; other site 292564001007 active site 292564001008 Protein of unknown function (DUF2605); Region: DUF2605; pfam10792 292564001009 Protein of unknown function, DUF547; Region: DUF547; pfam04784 292564001010 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 292564001011 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 292564001012 Probable Catalytic site; other site 292564001013 Methyltransferase domain; Region: Methyltransf_31; pfam13847 292564001014 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292564001015 S-adenosylmethionine binding site [chemical binding]; other site 292564001016 SAM (Sterile alpha motif ); Region: SAM_superfamily; cl15755 292564001017 Rrf2 family protein; Region: rrf2_super; TIGR00738 292564001018 Transcriptional regulator; Region: Rrf2; pfam02082 292564001019 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 292564001020 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 292564001021 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 292564001022 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 292564001023 nitrilase; Region: PLN02798 292564001024 putative active site [active] 292564001025 catalytic triad [active] 292564001026 dimer interface [polypeptide binding]; other site 292564001027 AMIN domain; Region: AMIN; pfam11741 292564001028 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 292564001029 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 292564001030 active site 292564001031 metal binding site [ion binding]; metal-binding site 292564001032 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 292564001033 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 292564001034 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 292564001035 substrate binding pocket [chemical binding]; other site 292564001036 chain length determination region; other site 292564001037 substrate-Mg2+ binding site; other site 292564001038 catalytic residues [active] 292564001039 aspartate-rich region 1; other site 292564001040 active site lid residues [active] 292564001041 aspartate-rich region 2; other site 292564001042 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 292564001043 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 292564001044 motif II; other site 292564001045 TspO/MBR family; Region: TspO_MBR; cl01379 292564001046 acetyl-CoA synthetase; Provisional; Region: PRK00174 292564001047 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 292564001048 active site 292564001049 CoA binding site [chemical binding]; other site 292564001050 acyl-activating enzyme (AAE) consensus motif; other site 292564001051 AMP binding site [chemical binding]; other site 292564001052 acetate binding site [chemical binding]; other site 292564001053 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 292564001054 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 292564001055 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 292564001056 catalytic triad [active] 292564001057 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 292564001058 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 292564001059 active site 292564001060 catalytic site [active] 292564001061 substrate binding site [chemical binding]; other site 292564001062 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 292564001063 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 292564001064 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 292564001065 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292564001066 Walker A/P-loop; other site 292564001067 ATP binding site [chemical binding]; other site 292564001068 Q-loop/lid; other site 292564001069 ABC transporter signature motif; other site 292564001070 Walker B; other site 292564001071 D-loop; other site 292564001072 H-loop/switch region; other site 292564001073 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 292564001074 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 292564001075 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 292564001076 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 292564001077 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 292564001078 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 292564001079 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 292564001080 catalytic site [active] 292564001081 subunit interface [polypeptide binding]; other site 292564001082 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 292564001083 anti sigma factor interaction site; other site 292564001084 regulatory phosphorylation site [posttranslational modification]; other site 292564001085 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 292564001086 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 292564001087 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 292564001088 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 292564001089 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 292564001090 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 292564001091 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 292564001092 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 292564001093 SnoaL-like domain; Region: SnoaL_3; pfam13474 292564001094 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK07374 292564001095 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 292564001096 active site 292564001097 PHP Thumb interface [polypeptide binding]; other site 292564001098 metal binding site [ion binding]; metal-binding site 292564001099 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 292564001100 generic binding surface I; other site 292564001101 generic binding surface II; other site 292564001102 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 292564001103 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 292564001104 16S/18S rRNA binding site [nucleotide binding]; other site 292564001105 S13e-L30e interaction site [polypeptide binding]; other site 292564001106 25S rRNA binding site [nucleotide binding]; other site 292564001107 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 292564001108 RuvA N terminal domain; Region: RuvA_N; pfam01330 292564001109 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 292564001110 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 292564001111 EamA-like transporter family; Region: EamA; pfam00892 292564001112 DNA primase; Validated; Region: dnaG; PRK05667 292564001113 CHC2 zinc finger; Region: zf-CHC2; pfam01807 292564001114 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 292564001115 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 292564001116 active site 292564001117 metal binding site [ion binding]; metal-binding site 292564001118 interdomain interaction site; other site 292564001119 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 292564001120 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 292564001121 GAF domain; Region: GAF; pfam01590 292564001122 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 292564001123 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 292564001124 metal binding site [ion binding]; metal-binding site 292564001125 active site 292564001126 I-site; other site 292564001127 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 292564001128 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 292564001129 active site 292564001130 DNA binding site [nucleotide binding] 292564001131 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 292564001132 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 292564001133 Catalytic site [active] 292564001134 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 292564001135 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292564001136 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292564001137 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 292564001138 I-site; other site 292564001139 active site 292564001140 metal binding site [ion binding]; metal-binding site 292564001141 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 292564001142 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 292564001143 HPP family; Region: HPP; pfam04982 292564001144 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 292564001145 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 292564001146 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 292564001147 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 292564001148 Protein of unknown function (DUF3082); Region: DUF3082; pfam11282 292564001149 pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144 292564001150 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 292564001151 alpha subunit interface [polypeptide binding]; other site 292564001152 TPP binding site [chemical binding]; other site 292564001153 heterodimer interface [polypeptide binding]; other site 292564001154 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 292564001155 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 292564001156 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 292564001157 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 292564001158 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 292564001159 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 292564001160 Protein export membrane protein; Region: SecD_SecF; pfam02355 292564001161 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 292564001162 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 292564001163 photosystem II reaction center protein Psb28; Provisional; Region: PRK13612 292564001164 GUN4-like; Region: GUN4; pfam05419 292564001165 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 292564001166 glutamine synthetase, type I; Region: GlnA; TIGR00653 292564001167 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 292564001168 Phycobilisome protein; Region: Phycobilisome; cl08227 292564001169 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 292564001170 homodimer interface [polypeptide binding]; other site 292564001171 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292564001172 catalytic residue [active] 292564001173 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 292564001174 nucleoside/Zn binding site; other site 292564001175 dimer interface [polypeptide binding]; other site 292564001176 catalytic motif [active] 292564001177 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 292564001178 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 292564001179 catalytic residue [active] 292564001180 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 292564001181 G1 box; other site 292564001182 GTP/Mg2+ binding site [chemical binding]; other site 292564001183 G2 box; other site 292564001184 Switch I region; other site 292564001185 G3 box; other site 292564001186 Switch II region; other site 292564001187 Domain of unknown function (DUF697); Region: DUF697; pfam05128 292564001188 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 292564001189 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 292564001190 phosphopeptide binding site; other site 292564001191 Transglycosylase; Region: Transgly; pfam00912 292564001192 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 292564001193 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 292564001194 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 292564001195 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 292564001196 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 292564001197 Protein of unknown function (DUF3148); Region: DUF3148; pfam11347 292564001198 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 292564001199 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 292564001200 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 292564001201 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 292564001202 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 292564001203 phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816 292564001204 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 292564001205 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 292564001206 HlyD family secretion protein; Region: HlyD_3; pfam13437 292564001207 DevC protein; Region: devC; TIGR01185 292564001208 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 292564001209 FtsX-like permease family; Region: FtsX; pfam02687 292564001210 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 292564001211 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 292564001212 Walker A/P-loop; other site 292564001213 ATP binding site [chemical binding]; other site 292564001214 Q-loop/lid; other site 292564001215 ABC transporter signature motif; other site 292564001216 Walker B; other site 292564001217 D-loop; other site 292564001218 H-loop/switch region; other site 292564001219 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 292564001220 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 292564001221 Probable Catalytic site; other site 292564001222 metal-binding site 292564001223 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 292564001224 rRNA interaction site [nucleotide binding]; other site 292564001225 S8 interaction site; other site 292564001226 putative laminin-1 binding site; other site 292564001227 elongation factor Ts; Reviewed; Region: tsf; PRK12332 292564001228 UBA/TS-N domain; Region: UBA; pfam00627 292564001229 Elongation factor TS; Region: EF_TS; pfam00889 292564001230 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 292564001231 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 292564001232 generic binding surface II; other site 292564001233 ssDNA binding site; other site 292564001234 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 292564001235 ATP binding site [chemical binding]; other site 292564001236 putative Mg++ binding site [ion binding]; other site 292564001237 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 292564001238 nucleotide binding region [chemical binding]; other site 292564001239 ATP-binding site [chemical binding]; other site 292564001240 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 292564001241 sulfite reductase subunit beta; Provisional; Region: PRK13504 292564001242 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 292564001243 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 292564001244 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 292564001245 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 292564001246 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 292564001247 malonyl-CoA binding site [chemical binding]; other site 292564001248 dimer interface [polypeptide binding]; other site 292564001249 active site 292564001250 product binding site; other site 292564001251 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 292564001252 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 292564001253 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292564001254 S-adenosylmethionine binding site [chemical binding]; other site 292564001255 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 292564001256 Domain of unknown function DUF21; Region: DUF21; pfam01595 292564001257 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 292564001258 Transporter associated domain; Region: CorC_HlyC; smart01091 292564001259 geranylgeranyl reductase; Region: ChlP; TIGR02028 292564001260 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 292564001261 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 292564001262 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 292564001263 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 292564001264 G1 box; other site 292564001265 putative GEF interaction site [polypeptide binding]; other site 292564001266 GTP/Mg2+ binding site [chemical binding]; other site 292564001267 Switch I region; other site 292564001268 G2 box; other site 292564001269 G3 box; other site 292564001270 Switch II region; other site 292564001271 G4 box; other site 292564001272 G5 box; other site 292564001273 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 292564001274 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 292564001275 Domain of unknown function (DUF309); Region: DUF309; pfam03745 292564001276 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 292564001277 OstA-like protein; Region: OstA; pfam03968 292564001278 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 292564001279 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 292564001280 Walker A/P-loop; other site 292564001281 ATP binding site [chemical binding]; other site 292564001282 Q-loop/lid; other site 292564001283 ABC transporter signature motif; other site 292564001284 Walker B; other site 292564001285 D-loop; other site 292564001286 H-loop/switch region; other site 292564001287 Predicted permeases [General function prediction only]; Region: COG0795 292564001288 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 292564001289 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 292564001290 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 292564001291 active site 292564001292 catalytic triad [active] 292564001293 oxyanion hole [active] 292564001294 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 292564001295 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 292564001296 substrate binding site [chemical binding]; other site 292564001297 hexamer interface [polypeptide binding]; other site 292564001298 metal binding site [ion binding]; metal-binding site 292564001299 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 292564001300 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 292564001301 putative active site [active] 292564001302 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 292564001303 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 292564001304 tRNA; other site 292564001305 putative tRNA binding site [nucleotide binding]; other site 292564001306 putative NADP binding site [chemical binding]; other site 292564001307 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 292564001308 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 292564001309 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 292564001310 ligand binding site; other site 292564001311 oligomer interface; other site 292564001312 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 292564001313 dimer interface [polypeptide binding]; other site 292564001314 N-terminal domain interface [polypeptide binding]; other site 292564001315 sulfate 1 binding site; other site 292564001316 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 292564001317 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 292564001318 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 292564001319 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 292564001320 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 292564001321 putative active site [active] 292564001322 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 292564001323 CheB methylesterase; Region: CheB_methylest; pfam01339 292564001324 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 292564001325 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 292564001326 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 292564001327 PAS domain; Region: PAS_10; pfam13596 292564001328 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292564001329 PAS fold; Region: PAS_3; pfam08447 292564001330 putative active site [active] 292564001331 heme pocket [chemical binding]; other site 292564001332 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 292564001333 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 292564001334 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 292564001335 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 292564001336 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 292564001337 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292564001338 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292564001339 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 292564001340 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 292564001341 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 292564001342 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 292564001343 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 292564001344 putative active site [active] 292564001345 catalytic triad [active] 292564001346 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 292564001347 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 292564001348 dimer interface [polypeptide binding]; other site 292564001349 decamer (pentamer of dimers) interface [polypeptide binding]; other site 292564001350 catalytic triad [active] 292564001351 peroxidatic and resolving cysteines [active] 292564001352 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 292564001353 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 292564001354 Peptidase family M23; Region: Peptidase_M23; pfam01551 292564001355 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 292564001356 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 292564001357 homotrimer interface [polypeptide binding]; other site 292564001358 Walker A motif; other site 292564001359 GTP binding site [chemical binding]; other site 292564001360 Walker B motif; other site 292564001361 proton extrusion protein PcxA; Provisional; Region: PRK02507 292564001362 Repair protein; Region: Repair_PSII; pfam04536 292564001363 Protein of unknown function (DUF2930); Region: DUF2930; pfam11152 292564001364 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 292564001365 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 292564001366 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 292564001367 active site 292564001368 HIGH motif; other site 292564001369 KMSKS motif; other site 292564001370 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 292564001371 tRNA binding surface [nucleotide binding]; other site 292564001372 anticodon binding site; other site 292564001373 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 292564001374 RNB domain; Region: RNB; pfam00773 292564001375 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 292564001376 ribosomal protein S18; Region: rps18; CHL00077 292564001377 ribosomal protein L33; Region: rpl33; CHL00104 292564001378 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 292564001379 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 292564001380 putative tRNA-binding site [nucleotide binding]; other site 292564001381 B3/4 domain; Region: B3_4; pfam03483 292564001382 tRNA synthetase B5 domain; Region: B5; smart00874 292564001383 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 292564001384 dimer interface [polypeptide binding]; other site 292564001385 motif 1; other site 292564001386 motif 3; other site 292564001387 motif 2; other site 292564001388 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 292564001389 TRAM domain; Region: TRAM; pfam01938 292564001390 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 292564001391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292564001392 S-adenosylmethionine binding site [chemical binding]; other site 292564001393 Phycobilisome protein; Region: Phycobilisome; cl08227 292564001394 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 292564001395 HSP70 interaction site [polypeptide binding]; other site 292564001396 Protein of unknown function (DUF3370); Region: DUF3370; pfam11850 292564001397 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 292564001398 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 292564001399 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 292564001400 DNA binding residues [nucleotide binding] 292564001401 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360 292564001402 ATP adenylyltransferase; Region: ATP_transf; pfam09830 292564001403 Stage II sporulation protein; Region: SpoIID; pfam08486 292564001404 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619 292564001405 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 292564001406 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 292564001407 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 292564001408 NAD(P) binding site [chemical binding]; other site 292564001409 active site 292564001410 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 292564001411 Protein of unknown function (DUF4090); Region: DUF4090; pfam13319 292564001412 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 292564001413 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 292564001414 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 292564001415 substrate binding pocket [chemical binding]; other site 292564001416 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 292564001417 B12 binding site [chemical binding]; other site 292564001418 cobalt ligand [ion binding]; other site 292564001419 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 292564001420 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 292564001421 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 292564001422 homodimer interface [polypeptide binding]; other site 292564001423 substrate-cofactor binding pocket; other site 292564001424 catalytic residue [active] 292564001425 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 292564001426 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 292564001427 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 292564001428 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 292564001429 active site 292564001430 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 292564001431 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 292564001432 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 292564001433 GIY-YIG motif/motif A; other site 292564001434 active site 292564001435 catalytic site [active] 292564001436 putative DNA binding site [nucleotide binding]; other site 292564001437 metal binding site [ion binding]; metal-binding site 292564001438 UvrB/uvrC motif; Region: UVR; pfam02151 292564001439 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 292564001440 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 292564001441 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 292564001442 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 292564001443 active site 292564001444 (T/H)XGH motif; other site 292564001445 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 292564001446 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 292564001447 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 292564001448 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 292564001449 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 292564001450 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 292564001451 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 292564001452 catalytic residue [active] 292564001453 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 292564001454 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 292564001455 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 292564001456 Sm and related proteins; Region: Sm_like; cl00259 292564001457 Sm1 motif; other site 292564001458 RNA binding site [nucleotide binding]; other site 292564001459 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 292564001460 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 292564001461 HIGH motif; other site 292564001462 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 292564001463 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 292564001464 active site 292564001465 KMSKS motif; other site 292564001466 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 292564001467 tRNA binding surface [nucleotide binding]; other site 292564001468 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 292564001469 S-formylglutathione hydrolase; Region: PLN02442 292564001470 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 292564001471 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 292564001472 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 292564001473 substrate binding site [chemical binding]; other site 292564001474 catalytic Zn binding site [ion binding]; other site 292564001475 NAD binding site [chemical binding]; other site 292564001476 structural Zn binding site [ion binding]; other site 292564001477 dimer interface [polypeptide binding]; other site 292564001478 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 292564001479 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 292564001480 active site 292564001481 dimer interface [polypeptide binding]; other site 292564001482 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 292564001483 dimer interface [polypeptide binding]; other site 292564001484 active site 292564001485 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 292564001486 amidase catalytic site [active] 292564001487 Zn binding residues [ion binding]; other site 292564001488 substrate binding site [chemical binding]; other site 292564001489 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 292564001490 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 292564001491 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 292564001492 protein binding site [polypeptide binding]; other site 292564001493 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 292564001494 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 292564001495 active site 292564001496 substrate binding site [chemical binding]; other site 292564001497 cosubstrate binding site; other site 292564001498 catalytic site [active] 292564001499 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 292564001500 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 292564001501 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319 292564001502 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 292564001503 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 292564001504 dimerization interface [polypeptide binding]; other site 292564001505 active site 292564001506 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 292564001507 HlyD family secretion protein; Region: HlyD_3; pfam13437 292564001508 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 292564001509 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 292564001510 ligand binding site [chemical binding]; other site 292564001511 flexible hinge region; other site 292564001512 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 292564001513 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 292564001514 putative active site [active] 292564001515 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 292564001516 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292564001517 Walker A/P-loop; other site 292564001518 ATP binding site [chemical binding]; other site 292564001519 Q-loop/lid; other site 292564001520 ABC transporter signature motif; other site 292564001521 Walker B; other site 292564001522 D-loop; other site 292564001523 H-loop/switch region; other site 292564001524 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 292564001525 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 292564001526 active site 292564001527 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 292564001528 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 292564001529 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 292564001530 putative active site [active] 292564001531 Protein of unknown function (DUF3110); Region: DUF3110; pfam11360 292564001532 chaperone protein DnaJ; Provisional; Region: PRK14299 292564001533 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 292564001534 HSP70 interaction site [polypeptide binding]; other site 292564001535 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 292564001536 molecular chaperone DnaK; Provisional; Region: PRK13410 292564001537 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 292564001538 nucleotide binding site [chemical binding]; other site 292564001539 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 292564001540 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 292564001541 dimer interface [polypeptide binding]; other site 292564001542 conserved gate region; other site 292564001543 putative PBP binding loops; other site 292564001544 ABC-ATPase subunit interface; other site 292564001545 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 292564001546 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 292564001547 dimer interface [polypeptide binding]; other site 292564001548 conserved gate region; other site 292564001549 putative PBP binding loops; other site 292564001550 ABC-ATPase subunit interface; other site 292564001551 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14259 292564001552 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 292564001553 Walker A/P-loop; other site 292564001554 ATP binding site [chemical binding]; other site 292564001555 Q-loop/lid; other site 292564001556 ABC transporter signature motif; other site 292564001557 Walker B; other site 292564001558 D-loop; other site 292564001559 H-loop/switch region; other site 292564001560 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 292564001561 catalytic loop [active] 292564001562 iron binding site [ion binding]; other site 292564001563 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 292564001564 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 292564001565 active site 292564001566 dimerization interface [polypeptide binding]; other site 292564001567 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 292564001568 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 292564001569 dimer interface [polypeptide binding]; other site 292564001570 motif 1; other site 292564001571 active site 292564001572 motif 2; other site 292564001573 motif 3; other site 292564001574 Ferredoxin [Energy production and conversion]; Region: COG1146 292564001575 heat shock protein 90; Provisional; Region: PRK05218 292564001576 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292564001577 ATP binding site [chemical binding]; other site 292564001578 Mg2+ binding site [ion binding]; other site 292564001579 G-X-G motif; other site 292564001580 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 292564001581 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 292564001582 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 292564001583 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 292564001584 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 292564001585 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 292564001586 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 292564001587 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292564001588 Walker A/P-loop; other site 292564001589 ATP binding site [chemical binding]; other site 292564001590 Q-loop/lid; other site 292564001591 ABC transporter signature motif; other site 292564001592 Walker B; other site 292564001593 D-loop; other site 292564001594 H-loop/switch region; other site 292564001595 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 292564001596 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 292564001597 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 292564001598 catalytic triad [active] 292564001599 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 292564001600 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 292564001601 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 292564001602 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 292564001603 photosystem I reaction center subunit X; Reviewed; Region: PRK13214 292564001604 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 292564001605 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 292564001606 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 292564001607 TPP-binding site; other site 292564001608 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 292564001609 PYR/PP interface [polypeptide binding]; other site 292564001610 dimer interface [polypeptide binding]; other site 292564001611 TPP binding site [chemical binding]; other site 292564001612 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 292564001613 threonine dehydratase; Reviewed; Region: PRK09224 292564001614 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 292564001615 tetramer interface [polypeptide binding]; other site 292564001616 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292564001617 catalytic residue [active] 292564001618 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 292564001619 putative Ile/Val binding site [chemical binding]; other site 292564001620 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 292564001621 putative Ile/Val binding site [chemical binding]; other site 292564001622 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 292564001623 YGGT family; Region: YGGT; pfam02325 292564001624 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 292564001625 putative metal binding site [ion binding]; other site 292564001626 pyruvate kinase; Provisional; Region: PRK06354 292564001627 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 292564001628 domain interfaces; other site 292564001629 active site 292564001630 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 292564001631 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 292564001632 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 292564001633 FtsX-like permease family; Region: FtsX; pfam02687 292564001634 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 292564001635 cell division protein; Validated; Region: ftsH; CHL00176 292564001636 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 292564001637 Walker A motif; other site 292564001638 ATP binding site [chemical binding]; other site 292564001639 Walker B motif; other site 292564001640 arginine finger; other site 292564001641 Peptidase family M41; Region: Peptidase_M41; pfam01434 292564001642 Clp protease; Region: CLP_protease; pfam00574 292564001643 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 292564001644 oligomer interface [polypeptide binding]; other site 292564001645 active site residues [active] 292564001646 photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060 292564001647 Thylakoid formation protein; Region: ThylakoidFormat; cl12138 292564001648 cytochrome b6-f complex subunit PetN; Provisional; Region: petN; PRK02529 292564001649 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 292564001650 Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651 292564001651 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 292564001652 ATP-grasp domain; Region: ATP-grasp; pfam02222 292564001653 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 292564001654 dimer interface [polypeptide binding]; other site 292564001655 conserved gate region; other site 292564001656 putative PBP binding loops; other site 292564001657 ABC-ATPase subunit interface; other site 292564001658 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 292564001659 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 292564001660 ATP binding site [chemical binding]; other site 292564001661 putative Mg++ binding site [ion binding]; other site 292564001662 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 292564001663 nucleotide binding region [chemical binding]; other site 292564001664 ATP-binding site [chemical binding]; other site 292564001665 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 292564001666 HRDC domain; Region: HRDC; pfam00570 292564001667 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 292564001668 active site 292564001669 dimer interface [polypeptide binding]; other site 292564001670 metal binding site [ion binding]; metal-binding site 292564001671 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 292564001672 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 292564001673 Repair protein; Region: Repair_PSII; pfam04536 292564001674 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 292564001675 catalytic residue [active] 292564001676 Myxococcus xanthus DevT and related proteins, metallophosphatase domain; Region: MPP_DevT; cd07397 292564001677 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 292564001678 putative active site [active] 292564001679 putative metal binding site [ion binding]; other site 292564001680 quinolinate synthetase; Provisional; Region: PRK09375 292564001681 Class I aldolases; Region: Aldolase_Class_I; cl17187 292564001682 catalytic residue [active] 292564001683 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 292564001684 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 292564001685 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 292564001686 ATP-dependent DNA ligase; Validated; Region: PRK09247 292564001687 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 292564001688 active site 292564001689 DNA binding site [nucleotide binding] 292564001690 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 292564001691 DNA binding site [nucleotide binding] 292564001692 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 292564001693 spermidine synthase; Provisional; Region: PRK03612 292564001694 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292564001695 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 292564001696 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 292564001697 ATP binding site [chemical binding]; other site 292564001698 putative Mg++ binding site [ion binding]; other site 292564001699 nucleotide binding region [chemical binding]; other site 292564001700 helicase superfamily c-terminal domain; Region: HELICc; smart00490 292564001701 ATP-binding site [chemical binding]; other site 292564001702 DEAD/H associated; Region: DEAD_assoc; pfam08494 292564001703 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 292564001704 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292564001705 calcium/proton exchanger (cax); Region: cax; TIGR00378 292564001706 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 292564001707 dimerization interface [polypeptide binding]; other site 292564001708 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 292564001709 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 292564001710 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 292564001711 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 292564001712 metal binding site [ion binding]; metal-binding site 292564001713 active site 292564001714 I-site; other site 292564001715 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 292564001716 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 292564001717 Methyltransferase domain; Region: Methyltransf_31; pfam13847 292564001718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292564001719 S-adenosylmethionine binding site [chemical binding]; other site 292564001720 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 292564001721 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 292564001722 G1 box; other site 292564001723 putative GEF interaction site [polypeptide binding]; other site 292564001724 GTP/Mg2+ binding site [chemical binding]; other site 292564001725 Switch I region; other site 292564001726 G2 box; other site 292564001727 G3 box; other site 292564001728 Switch II region; other site 292564001729 G4 box; other site 292564001730 G5 box; other site 292564001731 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 292564001732 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 292564001733 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 292564001734 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 292564001735 dimerization interface [polypeptide binding]; other site 292564001736 domain crossover interface; other site 292564001737 redox-dependent activation switch; other site 292564001738 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 292564001739 Walker A/P-loop; other site 292564001740 ATP binding site [chemical binding]; other site 292564001741 ABC transporter; Region: ABC_tran; pfam00005 292564001742 Q-loop/lid; other site 292564001743 ABC transporter signature motif; other site 292564001744 Walker B; other site 292564001745 D-loop; other site 292564001746 H-loop/switch region; other site 292564001747 Protein of unknown function (DUF3531); Region: DUF3531; pfam12049 292564001748 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 292564001749 Integral membrane protein DUF92; Region: DUF92; pfam01940 292564001750 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 292564001751 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 292564001752 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 292564001753 active site 292564001754 catalytic triad [active] 292564001755 oxyanion hole [active] 292564001756 aspartate aminotransferase; Provisional; Region: PRK05764 292564001757 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 292564001758 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292564001759 homodimer interface [polypeptide binding]; other site 292564001760 catalytic residue [active] 292564001761 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 292564001762 Fe-S cluster binding site [ion binding]; other site 292564001763 active site 292564001764 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 292564001765 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 292564001766 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 292564001767 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 292564001768 C-terminal peptidase (prc); Region: prc; TIGR00225 292564001769 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 292564001770 protein binding site [polypeptide binding]; other site 292564001771 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 292564001772 Catalytic dyad [active] 292564001773 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 292564001774 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 292564001775 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 292564001776 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 292564001777 ATP binding site [chemical binding]; other site 292564001778 putative Mg++ binding site [ion binding]; other site 292564001779 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 292564001780 nucleotide binding region [chemical binding]; other site 292564001781 ATP-binding site [chemical binding]; other site 292564001782 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 292564001783 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 292564001784 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 292564001785 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 292564001786 Integral membrane protein TerC family; Region: TerC; cl10468 292564001787 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 292564001788 DEAD-like helicases superfamily; Region: DEXDc; smart00487 292564001789 ATP binding site [chemical binding]; other site 292564001790 Mg++ binding site [ion binding]; other site 292564001791 motif III; other site 292564001792 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 292564001793 nucleotide binding region [chemical binding]; other site 292564001794 ATP-binding site [chemical binding]; other site 292564001795 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 292564001796 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 292564001797 putative active site [active] 292564001798 substrate binding site [chemical binding]; other site 292564001799 putative cosubstrate binding site; other site 292564001800 catalytic site [active] 292564001801 Formyl transferase, C-terminal domain; Region: Formyl_trans_C; pfam02911 292564001802 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 292564001803 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 292564001804 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 292564001805 diiron binding motif [ion binding]; other site 292564001806 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 292564001807 aromatic acid decarboxylase; Validated; Region: PRK05920 292564001808 Flavoprotein; Region: Flavoprotein; pfam02441 292564001809 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 292564001810 RNB domain; Region: RNB; pfam00773 292564001811 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 292564001812 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 292564001813 RNA binding site [nucleotide binding]; other site 292564001814 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 292564001815 Predicted membrane protein [Function unknown]; Region: COG2119 292564001816 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 292564001817 Flagellin N-methylase; Region: FliB; pfam03692 292564001818 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 292564001819 putative ion selectivity filter; other site 292564001820 putative pore gating glutamate residue; other site 292564001821 putative H+/Cl- coupling transport residue; other site 292564001822 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 292564001823 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 292564001824 DHH family; Region: DHH; pfam01368 292564001825 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 292564001826 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 292564001827 motif II; other site 292564001828 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 292564001829 active site 292564001830 ribosomal protein L32; Validated; Region: rpl32; CHL00152 292564001831 FtsH Extracellular; Region: FtsH_ext; pfam06480 292564001832 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 292564001833 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 292564001834 Walker A motif; other site 292564001835 ATP binding site [chemical binding]; other site 292564001836 Walker B motif; other site 292564001837 arginine finger; other site 292564001838 Peptidase family M41; Region: Peptidase_M41; pfam01434 292564001839 Cupin domain; Region: Cupin_2; pfam07883 292564001840 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 292564001841 MoaE interaction surface [polypeptide binding]; other site 292564001842 MoeB interaction surface [polypeptide binding]; other site 292564001843 thiocarboxylated glycine; other site 292564001844 threonine synthase; Validated; Region: PRK07591 292564001845 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 292564001846 homodimer interface [polypeptide binding]; other site 292564001847 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292564001848 catalytic residue [active] 292564001849 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 292564001850 Uncharacterized conserved protein [Function unknown]; Region: COG1615 292564001851 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 292564001852 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 292564001853 intersubunit interface [polypeptide binding]; other site 292564001854 active site 292564001855 zinc binding site [ion binding]; other site 292564001856 Na+ binding site [ion binding]; other site 292564001857 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 292564001858 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 292564001859 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 292564001860 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 292564001861 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 292564001862 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 292564001863 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 292564001864 active site 292564001865 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 292564001866 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 292564001867 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 292564001868 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 292564001869 trimer interface [polypeptide binding]; other site 292564001870 active site 292564001871 UDP-GlcNAc binding site [chemical binding]; other site 292564001872 lipid binding site [chemical binding]; lipid-binding site 292564001873 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 292564001874 Catalytic NodB homology domain of uncharacterized chitin deacetylases and hypothetical proteins; Region: CE4_NodB_like_2; cd10958 292564001875 NodB motif; other site 292564001876 putative active site [active] 292564001877 putative catalytic site [active] 292564001878 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 292564001879 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 292564001880 active site 292564001881 catalytic triad [active] 292564001882 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 292564001883 GAF domain; Region: GAF; pfam01590 292564001884 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 292564001885 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 292564001886 metal binding site [ion binding]; metal-binding site 292564001887 active site 292564001888 I-site; other site 292564001889 Mechanosensitive ion channel; Region: MS_channel; pfam00924 292564001890 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 292564001891 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 292564001892 ligand binding site [chemical binding]; other site 292564001893 flexible hinge region; other site 292564001894 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 292564001895 active site 292564001896 gamma-glutamyl kinase; Provisional; Region: PRK05429 292564001897 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 292564001898 nucleotide binding site [chemical binding]; other site 292564001899 homotetrameric interface [polypeptide binding]; other site 292564001900 putative phosphate binding site [ion binding]; other site 292564001901 putative allosteric binding site; other site 292564001902 PUA domain; Region: PUA; pfam01472 292564001903 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 292564001904 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 292564001905 active site 292564001906 motif I; other site 292564001907 motif II; other site 292564001908 Protein of unknown function (DUF3727); Region: DUF3727; pfam12527 292564001909 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 292564001910 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 292564001911 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 292564001912 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 292564001913 putative active site [active] 292564001914 PhoH-like protein; Region: PhoH; cl17668 292564001915 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 292564001916 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 292564001917 fumarate hydratase; Reviewed; Region: fumC; PRK00485 292564001918 Class II fumarases; Region: Fumarase_classII; cd01362 292564001919 active site 292564001920 tetramer interface [polypeptide binding]; other site 292564001921 Protein of unknown function (DUF3685); Region: DUF3685; pfam12452 292564001922 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 292564001923 metal binding site 2 [ion binding]; metal-binding site 292564001924 putative DNA binding helix; other site 292564001925 metal binding site 1 [ion binding]; metal-binding site 292564001926 dimer interface [polypeptide binding]; other site 292564001927 structural Zn2+ binding site [ion binding]; other site 292564001928 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 292564001929 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 292564001930 catalytic residues [active] 292564001931 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 292564001932 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 292564001933 putative NAD(P) binding site [chemical binding]; other site 292564001934 active site 292564001935 VanW like protein; Region: VanW; pfam04294 292564001936 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 292564001937 FOG: CBS domain [General function prediction only]; Region: COG0517 292564001938 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 292564001939 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 292564001940 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 292564001941 putative active site [active] 292564001942 putative metal binding site [ion binding]; other site 292564001943 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 292564001944 4Fe-4S binding domain; Region: Fer4_5; pfam12801 292564001945 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 292564001946 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 292564001947 putative active site pocket [active] 292564001948 dimerization interface [polypeptide binding]; other site 292564001949 putative catalytic residue [active] 292564001950 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 292564001951 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 292564001952 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 292564001953 putative metal binding site [ion binding]; other site 292564001954 Uncharacterized conserved protein [Function unknown]; Region: COG1432 292564001955 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 292564001956 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 292564001957 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 292564001958 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 292564001959 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 292564001960 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 292564001961 metal ion-dependent adhesion site (MIDAS); other site 292564001962 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 292564001963 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 292564001964 putative active site [active] 292564001965 putative metal binding site [ion binding]; other site 292564001966 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 292564001967 FeoA domain; Region: FeoA; pfam04023 292564001968 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 292564001969 GTP/Mg2+ binding site [chemical binding]; other site 292564001970 G1 box; other site 292564001971 G2 box; other site 292564001972 Switch I region; other site 292564001973 G3 box; other site 292564001974 Switch II region; other site 292564001975 G4 box; other site 292564001976 G5 box; other site 292564001977 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 292564001978 Nucleoside recognition; Region: Gate; pfam07670 292564001979 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 292564001980 Nucleoside recognition; Region: Gate; pfam07670 292564001981 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 292564001982 Ferritin-like domain; Region: Ferritin; pfam00210 292564001983 ferroxidase diiron center [ion binding]; other site 292564001984 PBP superfamily domain; Region: PBP_like_2; cl17296 292564001985 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292564001986 S-adenosylmethionine binding site [chemical binding]; other site 292564001987 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 292564001988 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 292564001989 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 292564001990 active site 292564001991 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 292564001992 active site 292564001993 hydroperoxidase II; Provisional; Region: katE; PRK11249 292564001994 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 292564001995 heme binding pocket [chemical binding]; other site 292564001996 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 292564001997 domain interactions; other site 292564001998 CsbD-like; Region: CsbD; cl17424 292564001999 magnesium chelatase subunit H; Provisional; Region: PRK12493 292564002000 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 292564002001 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 292564002002 dihydrodipicolinate reductase; Provisional; Region: PRK00048 292564002003 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 292564002004 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 292564002005 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 292564002006 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 292564002007 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 292564002008 active site 292564002009 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 292564002010 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 292564002011 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 292564002012 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 292564002013 AAA domain; Region: AAA_33; pfam13671 292564002014 active site 292564002015 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 292564002016 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 292564002017 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 292564002018 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 292564002019 Catalytic site [active] 292564002020 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 292564002021 dihydropteroate synthase; Region: DHPS; TIGR01496 292564002022 substrate binding pocket [chemical binding]; other site 292564002023 dimer interface [polypeptide binding]; other site 292564002024 inhibitor binding site; inhibition site 292564002025 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 292564002026 triosephosphate isomerase; Provisional; Region: PRK14565 292564002027 substrate binding site [chemical binding]; other site 292564002028 dimer interface [polypeptide binding]; other site 292564002029 catalytic triad [active] 292564002030 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 292564002031 RNA binding surface [nucleotide binding]; other site 292564002032 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 292564002033 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 292564002034 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292564002035 Walker A/P-loop; other site 292564002036 ATP binding site [chemical binding]; other site 292564002037 Q-loop/lid; other site 292564002038 ABC transporter signature motif; other site 292564002039 Walker B; other site 292564002040 D-loop; other site 292564002041 H-loop/switch region; other site 292564002042 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 292564002043 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 292564002044 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 292564002045 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 292564002046 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 292564002047 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 292564002048 ATP-grasp domain; Region: ATP-grasp_4; cl17255 292564002049 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 292564002050 substrate binding site [chemical binding]; other site 292564002051 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 292564002052 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 292564002053 Protein of unknown function (DUF1230); Region: DUF1230; pfam06799 292564002054 L-asparaginase II; Region: Asparaginase_II; pfam06089 292564002055 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 292564002056 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 292564002057 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 292564002058 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 292564002059 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 292564002060 putative active site [active] 292564002061 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 292564002062 putative active site [active] 292564002063 Putative ParB-like nuclease; Region: ParBc_2; cl17538 292564002064 Rieske non-heme iron oxygenase (RO) family, Pheophorbide a oxygenase (PaO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of a small subfamily of enzymes found in plants as well as oxygenic...; Region: Rieske_RO_Alpha_PaO; cd03480 292564002065 Pheophorbide a oxygenase; Region: PaO; pfam08417 292564002066 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 292564002067 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 292564002068 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 292564002069 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 292564002070 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 292564002071 Ligand Binding Site [chemical binding]; other site 292564002072 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 292564002073 Ligand Binding Site [chemical binding]; other site 292564002074 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 292564002075 Ligand Binding Site [chemical binding]; other site 292564002076 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 292564002077 CoA binding domain; Region: CoA_binding_2; pfam13380 292564002078 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 292564002079 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 292564002080 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 292564002081 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 292564002082 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 292564002083 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 292564002084 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 292564002085 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 292564002086 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 292564002087 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 292564002088 Fatty acid desaturase; Region: FA_desaturase; pfam00487 292564002089 putative di-iron ligands [ion binding]; other site 292564002090 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 292564002091 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 292564002092 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 292564002093 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 292564002094 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 292564002095 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 292564002096 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292564002097 Walker A/P-loop; other site 292564002098 ATP binding site [chemical binding]; other site 292564002099 Q-loop/lid; other site 292564002100 ABC transporter signature motif; other site 292564002101 Walker B; other site 292564002102 D-loop; other site 292564002103 H-loop/switch region; other site 292564002104 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 292564002105 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 292564002106 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 292564002107 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 292564002108 substrate binding site [chemical binding]; other site 292564002109 ATP binding site [chemical binding]; other site 292564002110 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 292564002111 active site 292564002112 Methyltransferase domain; Region: Methyltransf_11; pfam08241 292564002113 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 292564002114 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766 292564002115 light-harvesting-like protein 3; Provisional; Region: PLN00014 292564002116 DNA photolyase; Region: DNA_photolyase; pfam00875 292564002117 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 292564002118 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 292564002119 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 292564002120 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 292564002121 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 292564002122 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 292564002123 motif II; other site 292564002124 light-harvesting-like protein 3; Provisional; Region: PLN00014 292564002125 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 292564002126 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 292564002127 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 292564002128 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 292564002129 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 292564002130 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 292564002131 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 292564002132 DXD motif; other site 292564002133 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 292564002134 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 292564002135 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 292564002136 active site 292564002137 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 292564002138 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 292564002139 N-formylglutamate amidohydrolase; Region: FGase; cl01522 292564002140 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 292564002141 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 292564002142 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 292564002143 CsbD-like; Region: CsbD; cl17424 292564002144 Domain of unknown function DUF302; Region: DUF302; cl01364 292564002145 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 292564002146 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 292564002147 DNA binding residues [nucleotide binding] 292564002148 dimer interface [polypeptide binding]; other site 292564002149 metal binding site [ion binding]; metal-binding site 292564002150 Domain of unknown function (DUF305); Region: DUF305; pfam03713 292564002151 Domain of unknown function (DUF305); Region: DUF305; pfam03713 292564002152 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 292564002153 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 292564002154 Imelysin; Region: Peptidase_M75; pfam09375 292564002155 S-layer homology domain; Region: SLH; pfam00395 292564002156 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 292564002157 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 292564002158 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 292564002159 DNA binding residues [nucleotide binding] 292564002160 dimerization interface [polypeptide binding]; other site 292564002161 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 292564002162 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 292564002163 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 292564002164 trimer interface [polypeptide binding]; other site 292564002165 putative metal binding site [ion binding]; other site 292564002166 Photosystem II protein Y (PsbY); Region: PsbY; cl05675 292564002167 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 292564002168 Glucose inhibited division protein A; Region: GIDA; pfam01134 292564002169 Glucose inhibited division protein A; Region: GIDA; pfam01134 292564002170 carotene isomerase; Region: carot_isom; TIGR02730 292564002171 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 292564002172 hydroxyglutarate oxidase; Provisional; Region: PRK11728 292564002173 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 292564002174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292564002175 active site 292564002176 phosphorylation site [posttranslational modification] 292564002177 intermolecular recognition site; other site 292564002178 dimerization interface [polypeptide binding]; other site 292564002179 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 292564002180 DNA binding site [nucleotide binding] 292564002181 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 292564002182 putative GSH binding site [chemical binding]; other site 292564002183 catalytic residues [active] 292564002184 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 292564002185 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 292564002186 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 292564002187 putative acyl-acceptor binding pocket; other site 292564002188 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 292564002189 active site 292564002190 hydrophilic channel; other site 292564002191 dimerization interface [polypeptide binding]; other site 292564002192 catalytic residues [active] 292564002193 active site lid [active] 292564002194 Protein of unknown function (DUF2488); Region: Ycf54; pfam10674 292564002195 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 292564002196 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 292564002197 active site 292564002198 metal binding site [ion binding]; metal-binding site 292564002199 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 292564002200 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 292564002201 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 292564002202 Family description; Region: UvrD_C_2; pfam13538 292564002203 AAA domain; Region: AAA_30; pfam13604 292564002204 Family description; Region: UvrD_C_2; pfam13538 292564002205 Cupin domain; Region: Cupin_2; cl17218 292564002206 helicase 45; Provisional; Region: PTZ00424 292564002207 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 292564002208 ATP binding site [chemical binding]; other site 292564002209 Mg++ binding site [ion binding]; other site 292564002210 motif III; other site 292564002211 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 292564002212 nucleotide binding region [chemical binding]; other site 292564002213 ATP-binding site [chemical binding]; other site 292564002214 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 292564002215 putative RNA binding site [nucleotide binding]; other site 292564002216 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 292564002217 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 292564002218 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 292564002219 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 292564002220 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292564002221 Walker A/P-loop; other site 292564002222 ATP binding site [chemical binding]; other site 292564002223 Q-loop/lid; other site 292564002224 ABC transporter signature motif; other site 292564002225 Walker B; other site 292564002226 D-loop; other site 292564002227 H-loop/switch region; other site 292564002228 Transcriptional regulator [Transcription]; Region: LytR; COG1316 292564002229 MgtC family; Region: MgtC; pfam02308 292564002230 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 292564002231 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 292564002232 Outer membrane efflux protein; Region: OEP; pfam02321 292564002233 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 292564002234 dimer interface [polypeptide binding]; other site 292564002235 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 292564002236 GAF domain; Region: GAF; pfam01590 292564002237 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 292564002238 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 292564002239 metal binding site [ion binding]; metal-binding site 292564002240 active site 292564002241 I-site; other site 292564002242 NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794 292564002243 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 292564002244 HlyD family secretion protein; Region: HlyD_3; pfam13437 292564002245 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 292564002246 PsbP; Region: PsbP; pfam01789 292564002247 recombination protein RecR; Reviewed; Region: recR; PRK00076 292564002248 RecR protein; Region: RecR; pfam02132 292564002249 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 292564002250 putative active site [active] 292564002251 putative metal-binding site [ion binding]; other site 292564002252 tetramer interface [polypeptide binding]; other site 292564002253 lipoyl synthase; Provisional; Region: PRK12928 292564002254 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 292564002255 FeS/SAM binding site; other site 292564002256 Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627 292564002257 putative heme binding site [chemical binding]; other site 292564002258 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 292564002259 Phosphotransferase enzyme family; Region: APH; pfam01636 292564002260 active site 292564002261 substrate binding site [chemical binding]; other site 292564002262 ATP binding site [chemical binding]; other site 292564002263 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 292564002264 active site 292564002265 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 292564002266 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 292564002267 active site 292564002268 nucleotide binding site [chemical binding]; other site 292564002269 HIGH motif; other site 292564002270 KMSKS motif; other site 292564002271 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 292564002272 nudix motif; other site 292564002273 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 292564002274 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 292564002275 active site 292564002276 Staphylococcal nuclease homologues; Region: SNc; smart00318 292564002277 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 292564002278 Catalytic site; other site 292564002279 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 292564002280 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 292564002281 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 292564002282 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 292564002283 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 292564002284 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 292564002285 Soluble P-type ATPase [General function prediction only]; Region: COG4087 292564002286 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 292564002287 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 292564002288 superoxide dismutase; Provisional; Region: PRK10543 292564002289 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 292564002290 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 292564002291 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 292564002292 Lipase (class 2); Region: Lipase_2; pfam01674 292564002293 MarC family integral membrane protein; Region: MarC; cl00919 292564002294 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 292564002295 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 292564002296 putative acyl-acceptor binding pocket; other site 292564002297 Protein of unknown function, DUF393; Region: DUF393; pfam04134 292564002298 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 292564002299 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 292564002300 putative switch regulator; other site 292564002301 non-specific DNA interactions [nucleotide binding]; other site 292564002302 DNA binding site [nucleotide binding] 292564002303 sequence specific DNA binding site [nucleotide binding]; other site 292564002304 putative cAMP binding site [chemical binding]; other site 292564002305 Predicted membrane protein [Function unknown]; Region: COG3431 292564002306 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 292564002307 NMT1-like family; Region: NMT1_2; pfam13379 292564002308 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 292564002309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 292564002310 dimer interface [polypeptide binding]; other site 292564002311 conserved gate region; other site 292564002312 putative PBP binding loops; other site 292564002313 ABC-ATPase subunit interface; other site 292564002314 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 292564002315 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 292564002316 Walker A/P-loop; other site 292564002317 ATP binding site [chemical binding]; other site 292564002318 Q-loop/lid; other site 292564002319 ABC transporter signature motif; other site 292564002320 Walker B; other site 292564002321 D-loop; other site 292564002322 H-loop/switch region; other site 292564002323 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 292564002324 NMT1-like family; Region: NMT1_2; pfam13379 292564002325 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 292564002326 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 292564002327 Walker A/P-loop; other site 292564002328 ATP binding site [chemical binding]; other site 292564002329 Q-loop/lid; other site 292564002330 ABC transporter signature motif; other site 292564002331 Walker B; other site 292564002332 D-loop; other site 292564002333 H-loop/switch region; other site 292564002334 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 292564002335 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 292564002336 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 292564002337 non-specific DNA interactions [nucleotide binding]; other site 292564002338 DNA binding site [nucleotide binding] 292564002339 sequence specific DNA binding site [nucleotide binding]; other site 292564002340 putative cAMP binding site [chemical binding]; other site 292564002341 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 292564002342 Ferritin-like domain; Region: Ferritin; pfam00210 292564002343 ferroxidase diiron center [ion binding]; other site 292564002344 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 292564002345 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 292564002346 active site 292564002347 Zn binding site [ion binding]; other site 292564002348 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 292564002349 Protein of unknown function, DUF393; Region: DUF393; pfam04134 292564002350 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 292564002351 Peptidase family M23; Region: Peptidase_M23; pfam01551 292564002352 RDD family; Region: RDD; pfam06271 292564002353 Small T antigen; Reviewed; Region: PHA03102 292564002354 Phospholipid methyltransferase; Region: PEMT; cl17370 292564002355 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 292564002356 N-acetyl-D-glucosamine binding site [chemical binding]; other site 292564002357 catalytic residue [active] 292564002358 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 292564002359 trehalose synthase; Region: treS_nterm; TIGR02456 292564002360 active site 292564002361 catalytic site [active] 292564002362 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 292564002363 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 292564002364 substrate binding site [chemical binding]; other site 292564002365 ATP binding site [chemical binding]; other site 292564002366 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 292564002367 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 292564002368 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 292564002369 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 292564002370 putative ADP-binding pocket [chemical binding]; other site 292564002371 sucrose phosphate synthase, sucrose phosphatase-like domain, bacterial; Region: sucr_syn_bact_C; TIGR02471 292564002372 light-harvesting-like protein 3; Provisional; Region: PLN00014 292564002373 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 292564002374 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 292564002375 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 292564002376 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 292564002377 SPFH domain / Band 7 family; Region: Band_7; pfam01145 292564002378 Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449 292564002379 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 292564002380 Protein of unknown function (DUF3136); Region: DUF3136; pfam11334 292564002381 Cyagr_0992; ykkC-yxkD leader 292564002382 agmatinase; Region: agmatinase; TIGR01230 292564002383 Agmatinase-like family; Region: Agmatinase-like; cd09990 292564002384 active site 292564002385 oligomer interface [polypeptide binding]; other site 292564002386 Mn binding site [ion binding]; other site 292564002387 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 292564002388 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 292564002389 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 292564002390 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 292564002391 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 292564002392 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 292564002393 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 292564002394 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 292564002395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 292564002396 dimer interface [polypeptide binding]; other site 292564002397 conserved gate region; other site 292564002398 putative PBP binding loops; other site 292564002399 ABC-ATPase subunit interface; other site 292564002400 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 292564002401 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 292564002402 Walker A/P-loop; other site 292564002403 ATP binding site [chemical binding]; other site 292564002404 Q-loop/lid; other site 292564002405 ABC transporter signature motif; other site 292564002406 Walker B; other site 292564002407 D-loop; other site 292564002408 H-loop/switch region; other site 292564002409 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 292564002410 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 292564002411 [2Fe-2S] cluster binding site [ion binding]; other site 292564002412 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 292564002413 alpha subunit interface [polypeptide binding]; other site 292564002414 active site 292564002415 substrate binding site [chemical binding]; other site 292564002416 Fe binding site [ion binding]; other site 292564002417 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 292564002418 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 292564002419 putative di-iron ligands [ion binding]; other site 292564002420 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 292564002421 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 292564002422 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 292564002423 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 292564002424 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 292564002425 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 292564002426 DXD motif; other site 292564002427 Predicted transcriptional regulators [Transcription]; Region: COG1733 292564002428 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 292564002429 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 292564002430 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 292564002431 FMN binding site [chemical binding]; other site 292564002432 active site 292564002433 substrate binding site [chemical binding]; other site 292564002434 catalytic residue [active] 292564002435 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 292564002436 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 292564002437 Pirin-related protein [General function prediction only]; Region: COG1741 292564002438 Pirin; Region: Pirin; pfam02678 292564002439 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 292564002440 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 292564002441 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 292564002442 Protein of unknown function (DUF3136); Region: DUF3136; pfam11334 292564002443 tellurite resistance protein terB; Region: terB; cd07176 292564002444 putative metal binding site [ion binding]; other site 292564002445 hypothetical protein; Provisional; Region: PRK07236 292564002446 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 292564002447 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 292564002448 Domain of unknown function (DUF427); Region: DUF427; pfam04248 292564002449 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 292564002450 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 292564002451 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 292564002452 C-terminal domain interface [polypeptide binding]; other site 292564002453 GSH binding site (G-site) [chemical binding]; other site 292564002454 dimer interface [polypeptide binding]; other site 292564002455 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 292564002456 N-terminal domain interface [polypeptide binding]; other site 292564002457 Phycobilisome protein; Region: Phycobilisome; cl08227 292564002458 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 292564002459 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 292564002460 Nitrogen regulatory protein P-II; Region: P-II; smart00938 292564002461 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 292564002462 HetN oxidoreductase-like, classical (c) SDR; Region: HetN_like_SDR_c; cd08932 292564002463 putative NAD(P) binding site [chemical binding]; other site 292564002464 active site 292564002465 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 292564002466 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 292564002467 FeS/SAM binding site; other site 292564002468 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 292564002469 heme ligand [chemical binding]; other site 292564002470 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 292564002471 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 292564002472 NAD(P) binding site [chemical binding]; other site 292564002473 LDH/MDH dimer interface [polypeptide binding]; other site 292564002474 substrate binding site [chemical binding]; other site 292564002475 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 292564002476 active site clefts [active] 292564002477 zinc binding site [ion binding]; other site 292564002478 dimer interface [polypeptide binding]; other site 292564002479 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 292564002480 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 292564002481 homodimer interface [polypeptide binding]; other site 292564002482 substrate-cofactor binding pocket; other site 292564002483 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292564002484 catalytic residue [active] 292564002485 Phycobilisome protein; Region: Phycobilisome; cl08227 292564002486 Phycobilisome protein; Region: Phycobilisome; cl08227 292564002487 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 292564002488 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 292564002489 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 292564002490 catalytic residue [active] 292564002491 serine O-acetyltransferase; Region: cysE; TIGR01172 292564002492 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 292564002493 trimer interface [polypeptide binding]; other site 292564002494 active site 292564002495 substrate binding site [chemical binding]; other site 292564002496 CoA binding site [chemical binding]; other site 292564002497 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 292564002498 active site residue [active] 292564002499 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 292564002500 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 292564002501 dimer interface [polypeptide binding]; other site 292564002502 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292564002503 catalytic residue [active] 292564002504 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 292564002505 dinuclear metal binding motif [ion binding]; other site 292564002506 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 292564002507 dinuclear metal binding motif [ion binding]; other site 292564002508 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 292564002509 dimerization interface [polypeptide binding]; other site 292564002510 putative DNA binding site [nucleotide binding]; other site 292564002511 putative Zn2+ binding site [ion binding]; other site 292564002512 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 292564002513 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292564002514 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 292564002515 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292564002516 glutathione reductase; Validated; Region: PRK06116 292564002517 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 292564002518 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 292564002519 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 292564002520 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 292564002521 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 292564002522 catalytic loop [active] 292564002523 iron binding site [ion binding]; other site 292564002524 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 292564002525 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 292564002526 dimer interface [polypeptide binding]; other site 292564002527 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292564002528 catalytic residue [active] 292564002529 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 292564002530 aspartate aminotransferase; Provisional; Region: PRK05957 292564002531 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 292564002532 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292564002533 homodimer interface [polypeptide binding]; other site 292564002534 catalytic residue [active] 292564002535 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 292564002536 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 292564002537 putative active site [active] 292564002538 heme pocket [chemical binding]; other site 292564002539 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 292564002540 dimer interface [polypeptide binding]; other site 292564002541 phosphorylation site [posttranslational modification] 292564002542 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292564002543 ATP binding site [chemical binding]; other site 292564002544 Mg2+ binding site [ion binding]; other site 292564002545 G-X-G motif; other site 292564002546 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 292564002547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292564002548 active site 292564002549 phosphorylation site [posttranslational modification] 292564002550 intermolecular recognition site; other site 292564002551 dimerization interface [polypeptide binding]; other site 292564002552 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 292564002553 DNA binding site [nucleotide binding] 292564002554 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 292564002555 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 292564002556 putative switch regulator; other site 292564002557 non-specific DNA interactions [nucleotide binding]; other site 292564002558 DNA binding site [nucleotide binding] 292564002559 sequence specific DNA binding site [nucleotide binding]; other site 292564002560 putative cAMP binding site [chemical binding]; other site 292564002561 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 292564002562 PBP superfamily domain; Region: PBP_like_2; cl17296 292564002563 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 292564002564 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 292564002565 oligomer interface [polypeptide binding]; other site 292564002566 metal binding site [ion binding]; metal-binding site 292564002567 metal binding site [ion binding]; metal-binding site 292564002568 Cl binding site [ion binding]; other site 292564002569 aspartate ring; other site 292564002570 basic sphincter; other site 292564002571 putative hydrophobic gate; other site 292564002572 periplasmic entrance; other site 292564002573 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 292564002574 active site 292564002575 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 292564002576 TrkA-N domain; Region: TrkA_N; pfam02254 292564002577 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 292564002578 homodimer interface [polypeptide binding]; other site 292564002579 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 292564002580 active site pocket [active] 292564002581 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 292564002582 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 292564002583 ligand binding site [chemical binding]; other site 292564002584 flexible hinge region; other site 292564002585 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 292564002586 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 292564002587 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 292564002588 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 292564002589 sulfate transport protein; Provisional; Region: cysT; CHL00187 292564002590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 292564002591 dimer interface [polypeptide binding]; other site 292564002592 conserved gate region; other site 292564002593 putative PBP binding loops; other site 292564002594 ABC-ATPase subunit interface; other site 292564002595 sulfate transport protein; Provisional; Region: cysT; CHL00187 292564002596 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 292564002597 dimer interface [polypeptide binding]; other site 292564002598 conserved gate region; other site 292564002599 putative PBP binding loops; other site 292564002600 ABC-ATPase subunit interface; other site 292564002601 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 292564002602 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 292564002603 Walker A/P-loop; other site 292564002604 ATP binding site [chemical binding]; other site 292564002605 Q-loop/lid; other site 292564002606 ABC transporter signature motif; other site 292564002607 Walker B; other site 292564002608 D-loop; other site 292564002609 H-loop/switch region; other site 292564002610 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 292564002611 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 292564002612 non-specific DNA interactions [nucleotide binding]; other site 292564002613 DNA binding site [nucleotide binding] 292564002614 sequence specific DNA binding site [nucleotide binding]; other site 292564002615 putative cAMP binding site [chemical binding]; other site 292564002616 Predicted transcriptional regulator [Transcription]; Region: COG1959 292564002617 Transcriptional regulator; Region: Rrf2; pfam02082 292564002618 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 292564002619 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 292564002620 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 292564002621 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 292564002622 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 292564002623 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 292564002624 putative active site [active] 292564002625 putative dimer interface [polypeptide binding]; other site 292564002626 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 292564002627 active site residue [active] 292564002628 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 292564002629 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 292564002630 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 292564002631 Chromate transporter; Region: Chromate_transp; pfam02417 292564002632 FAD binding domain; Region: FAD_binding_4; pfam01565 292564002633 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 292564002634 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 292564002635 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 292564002636 inhibitor-cofactor binding pocket; inhibition site 292564002637 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292564002638 catalytic residue [active] 292564002639 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 292564002640 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 292564002641 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 292564002642 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 292564002643 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 292564002644 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 292564002645 TM-ABC transporter signature motif; other site 292564002646 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 292564002647 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 292564002648 Walker A/P-loop; other site 292564002649 ATP binding site [chemical binding]; other site 292564002650 Q-loop/lid; other site 292564002651 ABC transporter signature motif; other site 292564002652 Walker B; other site 292564002653 D-loop; other site 292564002654 H-loop/switch region; other site 292564002655 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 292564002656 Walker A/P-loop; other site 292564002657 ATP binding site [chemical binding]; other site 292564002658 Q-loop/lid; other site 292564002659 ABC transporter signature motif; other site 292564002660 Walker B; other site 292564002661 D-loop; other site 292564002662 H-loop/switch region; other site 292564002663 Ion transport protein; Region: Ion_trans; pfam00520 292564002664 Ion channel; Region: Ion_trans_2; pfam07885 292564002665 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 292564002666 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 292564002667 active site 292564002668 catalytic site [active] 292564002669 substrate binding site [chemical binding]; other site 292564002670 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 292564002671 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 292564002672 dimer interface [polypeptide binding]; other site 292564002673 putative PBP binding regions; other site 292564002674 ABC-ATPase subunit interface; other site 292564002675 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 292564002676 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292564002677 Walker A/P-loop; other site 292564002678 ATP binding site [chemical binding]; other site 292564002679 Q-loop/lid; other site 292564002680 ABC transporter signature motif; other site 292564002681 Walker B; other site 292564002682 D-loop; other site 292564002683 H-loop/switch region; other site 292564002684 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 292564002685 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 292564002686 metal binding site [ion binding]; metal-binding site 292564002687 FOG: WD40 repeat [General function prediction only]; Region: COG2319 292564002688 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 292564002689 structural tetrad; other site 292564002690 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 292564002691 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 292564002692 P-loop, Walker A motif; other site 292564002693 Base recognition motif; other site 292564002694 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 292564002695 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 292564002696 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 292564002697 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 292564002698 Ion channel; Region: Ion_trans_2; pfam07885 292564002699 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 292564002700 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 292564002701 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 292564002702 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 292564002703 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 292564002704 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 292564002705 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 292564002706 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 292564002707 Calx-beta domain; Region: Calx-beta; pfam03160 292564002708 Calx-beta domain; Region: Calx-beta; cl02522 292564002709 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 292564002710 Calx-beta domain; Region: Calx-beta; pfam03160 292564002711 Calx-beta domain; Region: Calx-beta; cl02522 292564002712 Calx-beta domain; Region: Calx-beta; cl02522 292564002713 Calx-beta domain; Region: Calx-beta; pfam03160 292564002714 Calx-beta domain; Region: Calx-beta; cl02522 292564002715 Calx-beta domain; Region: Calx-beta; pfam03160 292564002716 Calx-beta domain; Region: Calx-beta; cl02522 292564002717 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 292564002718 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 292564002719 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 292564002720 MAPEG family; Region: MAPEG; cl09190 292564002721 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 292564002722 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 292564002723 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 292564002724 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 292564002725 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 292564002726 DRTGG domain; Region: DRTGG; pfam07085 292564002727 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 292564002728 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 292564002729 active site 292564002730 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 292564002731 Src Homology 3 domain superfamily; Region: SH3; cl17036 292564002732 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 292564002733 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 292564002734 active site 292564002735 HIGH motif; other site 292564002736 nucleotide binding site [chemical binding]; other site 292564002737 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 292564002738 active site 292564002739 KMSKS motif; other site 292564002740 Protein of unknown function (DUF1643); Region: DUF1643; pfam07799 292564002741 DNA polymerase I; Provisional; Region: PRK05755 292564002742 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 292564002743 active site 292564002744 metal binding site 1 [ion binding]; metal-binding site 292564002745 putative 5' ssDNA interaction site; other site 292564002746 metal binding site 3; metal-binding site 292564002747 metal binding site 2 [ion binding]; metal-binding site 292564002748 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 292564002749 putative DNA binding site [nucleotide binding]; other site 292564002750 putative metal binding site [ion binding]; other site 292564002751 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 292564002752 active site 292564002753 catalytic site [active] 292564002754 substrate binding site [chemical binding]; other site 292564002755 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 292564002756 active site 292564002757 DNA binding site [nucleotide binding] 292564002758 catalytic site [active] 292564002759 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 292564002760 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 292564002761 NADP binding site [chemical binding]; other site 292564002762 active site 292564002763 putative substrate binding site [chemical binding]; other site 292564002764 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 292564002765 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 292564002766 NAD binding site [chemical binding]; other site 292564002767 substrate binding site [chemical binding]; other site 292564002768 homodimer interface [polypeptide binding]; other site 292564002769 active site 292564002770 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 292564002771 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 292564002772 active site 292564002773 HIGH motif; other site 292564002774 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 292564002775 KMSKS motif; other site 292564002776 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 292564002777 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 292564002778 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 292564002779 Methyltransferase domain; Region: Methyltransf_23; pfam13489 292564002780 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292564002781 Exostosin family; Region: Exostosin; pfam03016 292564002782 Protein of unknown function (DUF563); Region: DUF563; pfam04577 292564002783 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 292564002784 oligomeric interface; other site 292564002785 putative active site [active] 292564002786 homodimer interface [polypeptide binding]; other site 292564002787 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 292564002788 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 292564002789 Probable Catalytic site; other site 292564002790 metal-binding site 292564002791 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 292564002792 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 292564002793 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 292564002794 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 292564002795 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 292564002796 ligand binding site [chemical binding]; other site 292564002797 flexible hinge region; other site 292564002798 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 292564002799 putative active site [active] 292564002800 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 292564002801 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 292564002802 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292564002803 Walker A/P-loop; other site 292564002804 ATP binding site [chemical binding]; other site 292564002805 Q-loop/lid; other site 292564002806 ABC transporter signature motif; other site 292564002807 Walker B; other site 292564002808 D-loop; other site 292564002809 H-loop/switch region; other site 292564002810 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 292564002811 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 292564002812 HlyD family secretion protein; Region: HlyD_3; pfam13437 292564002813 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 292564002814 putative ADP-binding pocket [chemical binding]; other site 292564002815 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 292564002816 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292564002817 TPR motif; other site 292564002818 binding surface 292564002819 ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782 292564002820 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 292564002821 active site 292564002822 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 292564002823 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 292564002824 putative active site [active] 292564002825 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 292564002826 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 292564002827 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 292564002828 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 292564002829 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 292564002830 dimer interface [polypeptide binding]; other site 292564002831 [2Fe-2S] cluster binding site [ion binding]; other site 292564002832 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 292564002833 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 292564002834 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 292564002835 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 292564002836 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 292564002837 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 292564002838 ligand binding site [chemical binding]; other site 292564002839 homodimer interface [polypeptide binding]; other site 292564002840 NAD(P) binding site [chemical binding]; other site 292564002841 trimer interface B [polypeptide binding]; other site 292564002842 trimer interface A [polypeptide binding]; other site 292564002843 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 292564002844 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 292564002845 ATP binding site [chemical binding]; other site 292564002846 nucleotide binding region [chemical binding]; other site 292564002847 helicase superfamily c-terminal domain; Region: HELICc; smart00490 292564002848 ATP-binding site [chemical binding]; other site 292564002849 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 292564002850 rRNA binding site [nucleotide binding]; other site 292564002851 predicted 30S ribosome binding site; other site 292564002852 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 292564002853 pseudouridine synthase; Region: TIGR00093 292564002854 active site 292564002855 Ycf39; Provisional; Region: ycf39; CHL00194 292564002856 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 292564002857 NAD(P) binding site [chemical binding]; other site 292564002858 putative active site [active] 292564002859 cytochrome b6-f complex subunit PetM; Reviewed; Region: petM; PRK11876 292564002860 N2,N2-dimethylguanosine tRNA methyltransferase; Region: TRM; pfam02005 292564002861 hydrolase, alpha/beta fold family protein; Region: PLN02824 292564002862 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 292564002863 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 292564002864 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 292564002865 putative valine binding site [chemical binding]; other site 292564002866 dimer interface [polypeptide binding]; other site 292564002867 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 292564002868 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 292564002869 active site 292564002870 photosystem I assembly protein Ycf4; Provisional; Region: PRK02542 292564002871 D2 subunit of photosystem II (PS II); Region: Photosystem-II_D2; cd09288 292564002872 D1 interface; other site 292564002873 chlorophyll binding site; other site 292564002874 pheophytin binding site; other site 292564002875 beta carotene binding site; other site 292564002876 cytochrome b559 beta interface; other site 292564002877 quinone binding site; other site 292564002878 cytochrome b559 alpha interface; other site 292564002879 protein J interface; other site 292564002880 protein H interface; other site 292564002881 protein X interface; other site 292564002882 core light harvesting protein interface; other site 292564002883 protein L interface; other site 292564002884 CP43 interface; other site 292564002885 protein T interface; other site 292564002886 Fe binding site [ion binding]; other site 292564002887 protein M interface; other site 292564002888 Mn-stabilizing polypeptide interface; other site 292564002889 bromide binding site; other site 292564002890 cytochrome c-550 interface; other site 292564002891 photosystem II 44 kDa protein; Region: psbC; CHL00035 292564002892 photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153 292564002893 Maf-like protein; Region: Maf; pfam02545 292564002894 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 292564002895 active site 292564002896 dimer interface [polypeptide binding]; other site 292564002897 cobyric acid synthase; Provisional; Region: PRK00784 292564002898 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 292564002899 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 292564002900 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 292564002901 catalytic triad [active] 292564002902 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 292564002903 catalytic loop [active] 292564002904 iron binding site [ion binding]; other site 292564002905 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 292564002906 Radical SAM superfamily; Region: Radical_SAM; pfam04055 292564002907 FeS/SAM binding site; other site 292564002908 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 292564002909 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 292564002910 UDP-galactopyranose mutase; Region: GLF; pfam03275 292564002911 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 292564002912 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 292564002913 Ligand Binding Site [chemical binding]; other site 292564002914 Uncharacterized conserved protein [Function unknown]; Region: COG0062 292564002915 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 292564002916 putative substrate binding site [chemical binding]; other site 292564002917 putative ATP binding site [chemical binding]; other site 292564002918 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 292564002919 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 292564002920 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 292564002921 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 292564002922 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 292564002923 DNA binding residues [nucleotide binding] 292564002924 pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149 292564002925 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 292564002926 tetramer interface [polypeptide binding]; other site 292564002927 TPP-binding site [chemical binding]; other site 292564002928 heterodimer interface [polypeptide binding]; other site 292564002929 phosphorylation loop region [posttranslational modification] 292564002930 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 292564002931 signal recognition particle protein; Provisional; Region: PRK10867 292564002932 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 292564002933 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 292564002934 P loop; other site 292564002935 GTP binding site [chemical binding]; other site 292564002936 Signal peptide binding domain; Region: SRP_SPB; pfam02978 292564002937 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 292564002938 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 292564002939 PhoH-like protein; Region: PhoH; pfam02562 292564002940 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 292564002941 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 292564002942 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 292564002943 NADP-binding site; other site 292564002944 homotetramer interface [polypeptide binding]; other site 292564002945 substrate binding site [chemical binding]; other site 292564002946 homodimer interface [polypeptide binding]; other site 292564002947 active site 292564002948 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 292564002949 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 292564002950 NADP binding site [chemical binding]; other site 292564002951 active site 292564002952 putative substrate binding site [chemical binding]; other site 292564002953 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 292564002954 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 292564002955 NAD binding site [chemical binding]; other site 292564002956 homodimer interface [polypeptide binding]; other site 292564002957 active site 292564002958 substrate binding site [chemical binding]; other site 292564002959 TIGR03790 family protein; Region: TIGR03790 292564002960 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 292564002961 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 292564002962 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292564002963 Walker A/P-loop; other site 292564002964 ATP binding site [chemical binding]; other site 292564002965 Q-loop/lid; other site 292564002966 ABC transporter signature motif; other site 292564002967 Walker B; other site 292564002968 D-loop; other site 292564002969 H-loop/switch region; other site 292564002970 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 292564002971 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 292564002972 Ligand binding site; other site 292564002973 metal-binding site 292564002974 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 292564002975 Ligand Binding Site [chemical binding]; other site 292564002976 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 292564002977 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 292564002978 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 292564002979 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 292564002980 metal-binding site 292564002981 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 292564002982 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 292564002983 active site 292564002984 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 292564002985 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 292564002986 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 292564002987 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 292564002988 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 292564002989 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 292564002990 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 292564002991 active site 292564002992 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 292564002993 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 292564002994 active site 292564002995 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 292564002996 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 292564002997 active site 292564002998 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 292564002999 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 292564003000 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 292564003001 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 292564003002 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 292564003003 putative ADP-binding pocket [chemical binding]; other site 292564003004 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 292564003005 putative metal binding site; other site 292564003006 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 292564003007 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 292564003008 NAD(P) binding site [chemical binding]; other site 292564003009 active site 292564003010 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 292564003011 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 292564003012 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 292564003013 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 292564003014 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 292564003015 active site 292564003016 dimer interface [polypeptide binding]; other site 292564003017 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 292564003018 Ligand Binding Site [chemical binding]; other site 292564003019 Molecular Tunnel; other site 292564003020 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 292564003021 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 292564003022 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 292564003023 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 292564003024 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 292564003025 active site 292564003026 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 292564003027 putative active site [active] 292564003028 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 292564003029 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 292564003030 Mg++ binding site [ion binding]; other site 292564003031 putative catalytic motif [active] 292564003032 putative substrate binding site [chemical binding]; other site 292564003033 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 292564003034 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 292564003035 NAD(P) binding site [chemical binding]; other site 292564003036 homodimer interface [polypeptide binding]; other site 292564003037 substrate binding site [chemical binding]; other site 292564003038 active site 292564003039 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 292564003040 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 292564003041 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 292564003042 active site 292564003043 catalytic residues [active] 292564003044 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 292564003045 AAA domain; Region: AAA_31; pfam13614 292564003046 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 292564003047 Nucleotide binding site [chemical binding]; other site 292564003048 P loop; other site 292564003049 DTAP/Switch II; other site 292564003050 Switch I; other site 292564003051 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 292564003052 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 292564003053 SLBB domain; Region: SLBB; pfam10531 292564003054 SLBB domain; Region: SLBB; pfam10531 292564003055 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 292564003056 GTPase Era; Reviewed; Region: era; PRK00089 292564003057 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 292564003058 G1 box; other site 292564003059 GTP/Mg2+ binding site [chemical binding]; other site 292564003060 Switch I region; other site 292564003061 G2 box; other site 292564003062 Switch II region; other site 292564003063 G3 box; other site 292564003064 G4 box; other site 292564003065 G5 box; other site 292564003066 KH domain; Region: KH_2; pfam07650 292564003067 CpeS-like protein; Region: CpeS; pfam09367 292564003068 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 292564003069 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 292564003070 homotrimer interaction site [polypeptide binding]; other site 292564003071 zinc binding site [ion binding]; other site 292564003072 CDP-binding sites; other site 292564003073 uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792 292564003074 AIR carboxylase; Region: AIRC; smart01001 292564003075 Protein of unknown function (DUF1517); Region: DUF1517; pfam07466 292564003076 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 292564003077 thiS-thiF/thiG interaction site; other site 292564003078 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 292564003079 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 292564003080 thiamine phosphate binding site [chemical binding]; other site 292564003081 active site 292564003082 pyrophosphate binding site [ion binding]; other site 292564003083 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 292564003084 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 292564003085 active site 292564003086 Riboflavin kinase; Region: Flavokinase; smart00904 292564003087 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 292564003088 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 292564003089 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 292564003090 phenylalanyl-tRNA synthetase, alpha subunit; Region: pheS; TIGR00468 292564003091 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 292564003092 dimer interface [polypeptide binding]; other site 292564003093 motif 1; other site 292564003094 active site 292564003095 motif 2; other site 292564003096 motif 3; other site 292564003097 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649 292564003098 ATP-NAD kinase; Region: NAD_kinase; pfam01513 292564003099 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 292564003100 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 292564003101 DNA binding site [nucleotide binding] 292564003102 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 292564003103 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 292564003104 active site 292564003105 putative homodimer interface [polypeptide binding]; other site 292564003106 SAM binding site [chemical binding]; other site 292564003107 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 292564003108 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 292564003109 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 292564003110 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 292564003111 Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354 292564003112 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 292564003113 Protein of unknown function, DUF608; Region: DUF608; pfam04685 292564003114 Protein of unknown function (DUF3122); Region: DUF3122; pfam11320 292564003115 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 292564003116 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 292564003117 catalytic motif [active] 292564003118 Zn binding site [ion binding]; other site 292564003119 RibD C-terminal domain; Region: RibD_C; cl17279 292564003120 Protein of unknown function (DUF563); Region: DUF563; pfam04577 292564003121 Domain of unknown function (DUF427); Region: DUF427; pfam04248 292564003122 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 292564003123 FtsH Extracellular; Region: FtsH_ext; pfam06480 292564003124 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 292564003125 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 292564003126 Walker A motif; other site 292564003127 ATP binding site [chemical binding]; other site 292564003128 Walker B motif; other site 292564003129 arginine finger; other site 292564003130 Peptidase family M41; Region: Peptidase_M41; pfam01434 292564003131 ornithine carbamoyltransferase; Provisional; Region: PRK00779 292564003132 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 292564003133 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 292564003134 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 292564003135 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 292564003136 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 292564003137 Catalytic site [active] 292564003138 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 292564003139 active site 292564003140 catalytic residues [active] 292564003141 DNA binding site [nucleotide binding] 292564003142 Int/Topo IB signature motif; other site 292564003143 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 292564003144 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 292564003145 ATP binding site [chemical binding]; other site 292564003146 putative Mg++ binding site [ion binding]; other site 292564003147 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 292564003148 nucleotide binding region [chemical binding]; other site 292564003149 ATP-binding site [chemical binding]; other site 292564003150 Methyltransferase domain; Region: Methyltransf_26; pfam13659 292564003151 Fic family protein [Function unknown]; Region: COG3177 292564003152 Fic/DOC family; Region: Fic; pfam02661 292564003153 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 292564003154 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 292564003155 ATP-binding site [chemical binding]; other site 292564003156 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 292564003157 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 292564003158 PLD-like domain; Region: PLDc_2; pfam13091 292564003159 putative active site [active] 292564003160 catalytic site [active] 292564003161 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 292564003162 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 292564003163 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 292564003164 Sulfatase; Region: Sulfatase; pfam00884 292564003165 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 292564003166 Uncharacterized conserved protein [Function unknown]; Region: COG1262 292564003167 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 292564003168 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 292564003169 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 292564003170 Mechanosensitive ion channel; Region: MS_channel; pfam00924 292564003171 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 292564003172 Mechanosensitive ion channel; Region: MS_channel; pfam00924 292564003173 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 292564003174 active site 292564003175 catalytic triad [active] 292564003176 dimer interface [polypeptide binding]; other site 292564003177 Uncharacterized conserved protein [Function unknown]; Region: COG3937 292564003178 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 292564003179 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 292564003180 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 292564003181 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 292564003182 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 292564003183 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 292564003184 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 292564003185 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 292564003186 E3 interaction surface; other site 292564003187 lipoyl attachment site [posttranslational modification]; other site 292564003188 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 292564003189 e3 binding domain; Region: E3_binding; pfam02817 292564003190 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 292564003191 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 292564003192 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 292564003193 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 292564003194 acyl-activating enzyme (AAE) consensus motif; other site 292564003195 AMP binding site [chemical binding]; other site 292564003196 active site 292564003197 CoA binding site [chemical binding]; other site 292564003198 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 292564003199 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 292564003200 30S subunit binding site; other site 292564003201 Class I aldolases; Region: Aldolase_Class_I; cl17187 292564003202 catalytic residue [active] 292564003203 Recombination protein O N terminal; Region: RecO_N; pfam11967 292564003204 Recombination protein O C terminal; Region: RecO_C; pfam02565 292564003205 H+ Antiporter protein; Region: 2A0121; TIGR00900 292564003206 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 292564003207 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 292564003208 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292564003209 Response regulator receiver domain; Region: Response_reg; pfam00072 292564003210 active site 292564003211 phosphorylation site [posttranslational modification] 292564003212 intermolecular recognition site; other site 292564003213 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 292564003214 HAMP domain; Region: HAMP; pfam00672 292564003215 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292564003216 dimer interface [polypeptide binding]; other site 292564003217 phosphorylation site [posttranslational modification] 292564003218 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292564003219 ATP binding site [chemical binding]; other site 292564003220 Mg2+ binding site [ion binding]; other site 292564003221 G-X-G motif; other site 292564003222 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 292564003223 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 292564003224 putative ADP-binding pocket [chemical binding]; other site 292564003225 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 292564003226 EamA-like transporter family; Region: EamA; pfam00892 292564003227 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 292564003228 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 292564003229 tandem repeat interface [polypeptide binding]; other site 292564003230 oligomer interface [polypeptide binding]; other site 292564003231 active site residues [active] 292564003232 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 292564003233 homotrimer interaction site [polypeptide binding]; other site 292564003234 active site 292564003235 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 292564003236 Ribonuclease P; Region: Ribonuclease_P; cl00457 292564003237 Bacterial PH domain; Region: DUF304; pfam03703 292564003238 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654 292564003239 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 292564003240 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 292564003241 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 292564003242 Ycf46; Provisional; Region: ycf46; CHL00195 292564003243 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 292564003244 Walker A motif; other site 292564003245 ATP binding site [chemical binding]; other site 292564003246 Walker B motif; other site 292564003247 arginine finger; other site 292564003248 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 292564003249 Virulence-associated protein E; Region: VirE; pfam05272 292564003250 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 292564003251 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 292564003252 catalytic residues [active] 292564003253 catalytic nucleophile [active] 292564003254 Presynaptic Site I dimer interface [polypeptide binding]; other site 292564003255 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 292564003256 Synaptic Flat tetramer interface [polypeptide binding]; other site 292564003257 Synaptic Site I dimer interface [polypeptide binding]; other site 292564003258 DNA binding site [nucleotide binding] 292564003259 Recombinase; Region: Recombinase; pfam07508 292564003260 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 292564003261 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 292564003262 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 292564003263 active site 292564003264 catalytic residues [active] 292564003265 DNA binding site [nucleotide binding] 292564003266 Int/Topo IB signature motif; other site 292564003267 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 292564003268 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 292564003269 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 292564003270 catalytic residue [active] 292564003271 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 292564003272 amphipathic channel; other site 292564003273 Asn-Pro-Ala signature motifs; other site 292564003274 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 292564003275 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 292564003276 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 292564003277 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 292564003278 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 292564003279 Haemolytic domain; Region: Haemolytic; pfam01809 292564003280 ribosomal protein S4; Reviewed; Region: rps4; CHL00113 292564003281 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 292564003282 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 292564003283 RNA binding surface [nucleotide binding]; other site 292564003284 Methyltransferase domain; Region: Methyltransf_31; pfam13847 292564003285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292564003286 S-adenosylmethionine binding site [chemical binding]; other site 292564003287 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 292564003288 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 292564003289 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 292564003290 DevC protein; Region: devC; TIGR01185 292564003291 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 292564003292 FtsX-like permease family; Region: FtsX; pfam02687 292564003293 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 292564003294 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 292564003295 Walker A/P-loop; other site 292564003296 ATP binding site [chemical binding]; other site 292564003297 Q-loop/lid; other site 292564003298 ABC transporter signature motif; other site 292564003299 Walker B; other site 292564003300 D-loop; other site 292564003301 H-loop/switch region; other site 292564003302 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 292564003303 active site 292564003304 ribulose/triose binding site [chemical binding]; other site 292564003305 phosphate binding site [ion binding]; other site 292564003306 substrate (anthranilate) binding pocket [chemical binding]; other site 292564003307 product (indole) binding pocket [chemical binding]; other site 292564003308 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 292564003309 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 292564003310 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 292564003311 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 292564003312 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 292564003313 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 292564003314 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 292564003315 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 292564003316 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 292564003317 hinge; other site 292564003318 active site 292564003319 acetylornithine aminotransferase; Provisional; Region: PRK02627 292564003320 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 292564003321 inhibitor-cofactor binding pocket; inhibition site 292564003322 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292564003323 catalytic residue [active] 292564003324 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 292564003325 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292564003326 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 292564003327 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292564003328 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 292564003329 FAD binding domain; Region: FAD_binding_4; pfam01565 292564003330 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 292564003331 active site 292564003332 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 292564003333 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 292564003334 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 292564003335 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 292564003336 active site 292564003337 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333 292564003338 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 292564003339 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 292564003340 FeS/SAM binding site; other site 292564003341 TRAM domain; Region: TRAM; pfam01938 292564003342 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 292564003343 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 292564003344 ATP-grasp domain; Region: ATP-grasp_4; cl17255 292564003345 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 292564003346 cell division protein FtsZ; Provisional; Region: PRK13018 292564003347 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 292564003348 nucleotide binding site [chemical binding]; other site 292564003349 SulA interaction site; other site 292564003350 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 292564003351 oligomerization interface [polypeptide binding]; other site 292564003352 active site 292564003353 metal binding site [ion binding]; metal-binding site 292564003354 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 292564003355 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 292564003356 FeS/SAM binding site; other site 292564003357 HemN C-terminal domain; Region: HemN_C; pfam06969 292564003358 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 292564003359 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 292564003360 putative active site [active] 292564003361 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 292564003362 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 292564003363 oligomer interface [polypeptide binding]; other site 292564003364 active site residues [active] 292564003365 Clp protease; Region: CLP_protease; pfam00574 292564003366 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 292564003367 oligomer interface [polypeptide binding]; other site 292564003368 active site residues [active] 292564003369 ketol-acid reductoisomerase; Provisional; Region: PRK05479 292564003370 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 292564003371 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 292564003372 CobD/Cbib protein; Region: CobD_Cbib; cl00561 292564003373 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 292564003374 Bacterial sugar transferase; Region: Bac_transf; pfam02397 292564003375 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 292564003376 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 292564003377 putative ADP-binding pocket [chemical binding]; other site 292564003378 Competence protein; Region: Competence; pfam03772 292564003379 Mechanosensitive ion channel; Region: MS_channel; pfam00924 292564003380 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 292564003381 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 292564003382 Domain of unknown function (DUF202); Region: DUF202; cl09954 292564003383 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 292564003384 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 292564003385 Uncharacterized conserved protein [Function unknown]; Region: COG1262 292564003386 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 292564003387 Sulfatase; Region: Sulfatase; pfam00884 292564003388 Helix-turn-helix domain; Region: HTH_18; pfam12833 292564003389 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 292564003390 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 292564003391 dimer interface [polypeptide binding]; other site 292564003392 motif 1; other site 292564003393 active site 292564003394 motif 2; other site 292564003395 motif 3; other site 292564003396 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 292564003397 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 292564003398 S-adenosylmethionine binding site [chemical binding]; other site 292564003399 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 292564003400 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 292564003401 substrate binding site [chemical binding]; other site 292564003402 glutamase interaction surface [polypeptide binding]; other site 292564003403 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 292564003404 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 292564003405 UbiA prenyltransferase family; Region: UbiA; pfam01040 292564003406 Transglycosylase; Region: Transgly; pfam00912 292564003407 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 292564003408 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 292564003409 NusB family; Region: NusB; pfam01029 292564003410 16S rRNA methyltransferase B; Provisional; Region: PRK14901 292564003411 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292564003412 S-adenosylmethionine binding site [chemical binding]; other site 292564003413 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 292564003414 DNA binding site [nucleotide binding] 292564003415 active site 292564003416 ATP-grasp ribosomal peptide maturase, MvdC family; Region: ATPgraspMvdC; TIGR04185 292564003417 ATP-grasp domain; Region: ATP-grasp_4; cl17255 292564003418 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 292564003419 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 292564003420 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 292564003421 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 292564003422 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 292564003423 ABC-ATPase subunit interface; other site 292564003424 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 292564003425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292564003426 active site 292564003427 phosphorylation site [posttranslational modification] 292564003428 intermolecular recognition site; other site 292564003429 dimerization interface [polypeptide binding]; other site 292564003430 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 292564003431 DNA binding site [nucleotide binding] 292564003432 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 292564003433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292564003434 active site 292564003435 phosphorylation site [posttranslational modification] 292564003436 intermolecular recognition site; other site 292564003437 dimerization interface [polypeptide binding]; other site 292564003438 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 292564003439 DNA binding site [nucleotide binding] 292564003440 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 292564003441 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292564003442 dimer interface [polypeptide binding]; other site 292564003443 phosphorylation site [posttranslational modification] 292564003444 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292564003445 ATP binding site [chemical binding]; other site 292564003446 Mg2+ binding site [ion binding]; other site 292564003447 G-X-G motif; other site 292564003448 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 292564003449 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 292564003450 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 292564003451 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 292564003452 Methyltransferase domain; Region: Methyltransf_23; pfam13489 292564003453 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292564003454 S-adenosylmethionine binding site [chemical binding]; other site 292564003455 Integrase core domain; Region: rve; pfam00665 292564003456 Transposase; Region: HTH_Tnp_1; pfam01527 292564003457 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 292564003458 putative transposase OrfB; Reviewed; Region: PHA02517 292564003459 HTH-like domain; Region: HTH_21; pfam13276 292564003460 Integrase core domain; Region: rve; pfam00665 292564003461 Integrase core domain; Region: rve_3; pfam13683 292564003462 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 292564003463 putative active site [active] 292564003464 Protein of unknown function (DUF433); Region: DUF433; pfam04255 292564003465 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 292564003466 HEPN domain; Region: HEPN; pfam05168 292564003467 GTP-binding protein LepA; Provisional; Region: PRK05433 292564003468 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 292564003469 G1 box; other site 292564003470 putative GEF interaction site [polypeptide binding]; other site 292564003471 GTP/Mg2+ binding site [chemical binding]; other site 292564003472 Switch I region; other site 292564003473 G2 box; other site 292564003474 G3 box; other site 292564003475 Switch II region; other site 292564003476 G4 box; other site 292564003477 G5 box; other site 292564003478 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 292564003479 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 292564003480 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 292564003481 Methyltransferase domain; Region: Methyltransf_31; pfam13847 292564003482 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292564003483 S-adenosylmethionine binding site [chemical binding]; other site 292564003484 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 292564003485 NifU-like domain; Region: NifU; pfam01106 292564003486 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 292564003487 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 292564003488 seryl-tRNA synthetase; Provisional; Region: PRK05431 292564003489 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 292564003490 dimer interface [polypeptide binding]; other site 292564003491 active site 292564003492 motif 1; other site 292564003493 motif 2; other site 292564003494 motif 3; other site 292564003495 PilZ domain; Region: PilZ; pfam07238 292564003496 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 292564003497 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 292564003498 active site 292564003499 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 292564003500 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 292564003501 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 292564003502 minor groove reading motif; other site 292564003503 helix-hairpin-helix signature motif; other site 292564003504 substrate binding pocket [chemical binding]; other site 292564003505 active site 292564003506 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 292564003507 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 292564003508 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 292564003509 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 292564003510 RNase E interface [polypeptide binding]; other site 292564003511 trimer interface [polypeptide binding]; other site 292564003512 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 292564003513 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 292564003514 RNase E interface [polypeptide binding]; other site 292564003515 trimer interface [polypeptide binding]; other site 292564003516 active site 292564003517 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 292564003518 putative nucleic acid binding region [nucleotide binding]; other site 292564003519 G-X-X-G motif; other site 292564003520 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 292564003521 RNA binding site [nucleotide binding]; other site 292564003522 domain interface; other site 292564003523 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 292564003524 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 292564003525 putative active site [active] 292564003526 homotetrameric interface [polypeptide binding]; other site 292564003527 metal binding site [ion binding]; metal-binding site 292564003528 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 292564003529 active site 292564003530 Predicted methyltransferases [General function prediction only]; Region: COG0313 292564003531 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 292564003532 putative SAM binding site [chemical binding]; other site 292564003533 putative homodimer interface [polypeptide binding]; other site 292564003534 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 292564003535 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 292564003536 putative active site [active] 292564003537 hypothetical protein; Provisional; Region: PRK11770 292564003538 Domain of unknown function (DUF307); Region: DUF307; pfam03733 292564003539 Domain of unknown function (DUF307); Region: DUF307; pfam03733 292564003540 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 292564003541 putative DNA binding site [nucleotide binding]; other site 292564003542 putative Zn2+ binding site [ion binding]; other site 292564003543 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 292564003544 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 292564003545 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 292564003546 Major Facilitator Superfamily; Region: MFS_1; pfam07690 292564003547 Domain of unknown function (DUF3598); Region: DUF3598; pfam12204 292564003548 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 292564003549 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 292564003550 putative active site [active] 292564003551 Zn binding site [ion binding]; other site 292564003552 PilZ domain; Region: PilZ; pfam07238 292564003553 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292564003554 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 292564003555 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292564003556 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 292564003557 protein I interface; other site 292564003558 D2 interface; other site 292564003559 protein T interface; other site 292564003560 chlorophyll binding site; other site 292564003561 beta carotene binding site; other site 292564003562 pheophytin binding site; other site 292564003563 manganese-stabilizing polypeptide interface; other site 292564003564 CP43 interface; other site 292564003565 protein L interface; other site 292564003566 oxygen evolving complex binding site; other site 292564003567 bromide binding site; other site 292564003568 quinone binding site; other site 292564003569 Fe binding site [ion binding]; other site 292564003570 core light harvesting interface; other site 292564003571 cytochrome b559 alpha subunit interface; other site 292564003572 cytochrome c-550 interface; other site 292564003573 protein J interface; other site 292564003574 aspartoacylase; Provisional; Region: PRK02259 292564003575 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 292564003576 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 292564003577 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 292564003578 N-terminal domain interface [polypeptide binding]; other site 292564003579 dimer interface [polypeptide binding]; other site 292564003580 substrate binding pocket (H-site) [chemical binding]; other site 292564003581 Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; pfam10063 292564003582 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 292564003583 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 292564003584 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 292564003585 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 292564003586 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 292564003587 CP12 domain; Region: CP12; pfam02672 292564003588 GTPase CgtA; Reviewed; Region: obgE; PRK12299 292564003589 GTP1/OBG; Region: GTP1_OBG; pfam01018 292564003590 Obg GTPase; Region: Obg; cd01898 292564003591 G1 box; other site 292564003592 GTP/Mg2+ binding site [chemical binding]; other site 292564003593 Switch I region; other site 292564003594 G2 box; other site 292564003595 G3 box; other site 292564003596 Switch II region; other site 292564003597 G4 box; other site 292564003598 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 292564003599 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292564003600 Walker A/P-loop; other site 292564003601 ATP binding site [chemical binding]; other site 292564003602 Q-loop/lid; other site 292564003603 ABC transporter signature motif; other site 292564003604 Walker B; other site 292564003605 D-loop; other site 292564003606 H-loop/switch region; other site 292564003607 TOBE domain; Region: TOBE_2; pfam08402 292564003608 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 292564003609 MutS domain III; Region: MutS_III; pfam05192 292564003610 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292564003611 Walker A/P-loop; other site 292564003612 ATP binding site [chemical binding]; other site 292564003613 Q-loop/lid; other site 292564003614 ABC transporter signature motif; other site 292564003615 Walker B; other site 292564003616 D-loop; other site 292564003617 H-loop/switch region; other site 292564003618 Smr domain; Region: Smr; pfam01713 292564003619 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 292564003620 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 292564003621 active site 292564003622 metal binding site [ion binding]; metal-binding site 292564003623 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 292564003624 dimer interface [polypeptide binding]; other site 292564003625 active site 292564003626 aspartate-rich active site metal binding site; other site 292564003627 allosteric magnesium binding site [ion binding]; other site 292564003628 Schiff base residues; other site 292564003629 chaperone protein DnaJ; Provisional; Region: PRK14299 292564003630 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 292564003631 HSP70 interaction site [polypeptide binding]; other site 292564003632 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 292564003633 substrate binding site [polypeptide binding]; other site 292564003634 dimer interface [polypeptide binding]; other site 292564003635 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 292564003636 PilZ domain; Region: PilZ; pfam07238 292564003637 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 292564003638 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 292564003639 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 292564003640 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 292564003641 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 292564003642 active site 292564003643 Na/Ca binding site [ion binding]; other site 292564003644 catalytic site [active] 292564003645 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 292564003646 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 292564003647 Peptidase S8 family domain, uncharacterized subfamily 15; Region: Peptidases_S8_15; cd07498 292564003648 active site 292564003649 catalytic triad [active] 292564003650 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 292564003651 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 292564003652 Walker A/P-loop; other site 292564003653 ATP binding site [chemical binding]; other site 292564003654 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 292564003655 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 292564003656 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 292564003657 ABC transporter signature motif; other site 292564003658 Walker B; other site 292564003659 D-loop; other site 292564003660 H-loop/switch region; other site 292564003661 PRC-barrel domain; Region: PRC; pfam05239 292564003662 methionine sulfoxide reductase B; Provisional; Region: PRK00222 292564003663 SelR domain; Region: SelR; pfam01641 292564003664 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 292564003665 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 292564003666 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 292564003667 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 292564003668 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 292564003669 Predicted integral membrane protein [Function unknown]; Region: COG0762 292564003670 Photosystem II reaction centre X protein (PsbX); Region: PsbX; pfam06596 292564003671 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 292564003672 translocation protein TolB; Provisional; Region: tolB; PRK02889 292564003673 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 292564003674 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 292564003675 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 292564003676 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 292564003677 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 292564003678 nucleotide binding site/active site [active] 292564003679 HIT family signature motif; other site 292564003680 catalytic residue [active] 292564003681 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 292564003682 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 292564003683 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 292564003684 Walker A motif; other site 292564003685 ATP binding site [chemical binding]; other site 292564003686 Walker B motif; other site 292564003687 arginine finger; other site 292564003688 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 292564003689 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 292564003690 Protein of unknown function (DUF3747); Region: DUF3747; pfam12565 292564003691 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 292564003692 active site 292564003693 catalytic residues [active] 292564003694 metal binding site [ion binding]; metal-binding site 292564003695 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 292564003696 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 292564003697 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 292564003698 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 292564003699 CsbD-like; Region: CsbD; cl17424 292564003700 RibD C-terminal domain; Region: RibD_C; cl17279 292564003701 short chain dehydrogenase; Validated; Region: PRK08324 292564003702 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 292564003703 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 292564003704 NAD(P) binding site [chemical binding]; other site 292564003705 active site 292564003706 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 292564003707 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 292564003708 putative NAD(P) binding site [chemical binding]; other site 292564003709 dimer interface [polypeptide binding]; other site 292564003710 Methyltransferase domain; Region: Methyltransf_31; pfam13847 292564003711 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292564003712 S-adenosylmethionine binding site [chemical binding]; other site 292564003713 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 292564003714 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 292564003715 active site residue [active] 292564003716 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 292564003717 active site residue [active] 292564003718 Cytochrome oxidase complex assembly protein 1; Region: Coa1; pfam08695 292564003719 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 292564003720 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 292564003721 Amidase; Region: Amidase; cl11426 292564003722 Amidase; Region: Amidase; cl11426 292564003723 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 292564003724 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 292564003725 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 292564003726 TrkA-N domain; Region: TrkA_N; pfam02254 292564003727 TrkA-C domain; Region: TrkA_C; pfam02080 292564003728 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 292564003729 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 292564003730 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 292564003731 ligand binding site [chemical binding]; other site 292564003732 flexible hinge region; other site 292564003733 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 292564003734 ABC transporter transmembrane region; Region: ABC_membrane_3; pfam13748 292564003735 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 292564003736 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 292564003737 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 292564003738 Coenzyme A binding pocket [chemical binding]; other site 292564003739 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 292564003740 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 292564003741 Putative transposase; Region: Y2_Tnp; pfam04986 292564003742 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 292564003743 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 292564003744 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 292564003745 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 292564003746 catalytic residue [active] 292564003747 FeS assembly protein SufD; Region: sufD; TIGR01981 292564003748 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 292564003749 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 292564003750 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 292564003751 Walker A/P-loop; other site 292564003752 ATP binding site [chemical binding]; other site 292564003753 Q-loop/lid; other site 292564003754 ABC transporter signature motif; other site 292564003755 Walker B; other site 292564003756 D-loop; other site 292564003757 H-loop/switch region; other site 292564003758 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 292564003759 putative ABC transporter; Region: ycf24; CHL00085 292564003760 ferredoxin thioreductase subunit beta; Validated; Region: ftrB; CHL00165 292564003761 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 292564003762 putative DNA binding site [nucleotide binding]; other site 292564003763 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 292564003764 putative Zn2+ binding site [ion binding]; other site 292564003765 Transcriptional regulator PadR-like family; Region: PadR; cl17335 292564003766 EamA-like transporter family; Region: EamA; cl17759 292564003767 CpeS-like protein; Region: CpeS; pfam09367 292564003768 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 292564003769 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 292564003770 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 292564003771 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 292564003772 putative active site [active] 292564003773 catalytic site [active] 292564003774 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 292564003775 putative active site [active] 292564003776 catalytic site [active] 292564003777 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 292564003778 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 292564003779 phosphoglucomutase; Region: PLN02307 292564003780 active site 292564003781 substrate binding site [chemical binding]; other site 292564003782 metal binding site [ion binding]; metal-binding site 292564003783 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 292564003784 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 292564003785 Glutaminase; Region: Glutaminase; cl00907 292564003786 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 292564003787 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 292564003788 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 292564003789 active site 292564003790 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 292564003791 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 292564003792 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 292564003793 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 292564003794 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 292564003795 HlyD family secretion protein; Region: HlyD_3; pfam13437 292564003796 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 292564003797 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 292564003798 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 292564003799 HlyD family secretion protein; Region: HlyD_3; pfam13437 292564003800 recombination factor protein RarA/unknown domain fusion protein; Reviewed; Region: PRK13341 292564003801 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 292564003802 Walker A motif; other site 292564003803 ATP binding site [chemical binding]; other site 292564003804 Walker B motif; other site 292564003805 arginine finger; other site 292564003806 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 292564003807 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 292564003808 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 292564003809 catalytic triad [active] 292564003810 Type III pantothenate kinase; Region: Pan_kinase; cl17198 292564003811 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 292564003812 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 292564003813 Active Sites [active] 292564003814 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 292564003815 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 292564003816 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 292564003817 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 292564003818 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 292564003819 motif II; other site 292564003820 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 292564003821 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 292564003822 HflX GTPase family; Region: HflX; cd01878 292564003823 G1 box; other site 292564003824 GTP/Mg2+ binding site [chemical binding]; other site 292564003825 Switch I region; other site 292564003826 G2 box; other site 292564003827 G3 box; other site 292564003828 Switch II region; other site 292564003829 G4 box; other site 292564003830 G5 box; other site 292564003831 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 292564003832 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 292564003833 dimer interface [polypeptide binding]; other site 292564003834 decamer (pentamer of dimers) interface [polypeptide binding]; other site 292564003835 catalytic triad [active] 292564003836 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 292564003837 Cation transport protein; Region: TrkH; cl17365 292564003838 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 292564003839 TrkA-N domain; Region: TrkA_N; pfam02254 292564003840 TrkA-C domain; Region: TrkA_C; pfam02080 292564003841 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 292564003842 Protein of unknown function (DUF1662); Region: DUF1662; pfam07878 292564003843 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 292564003844 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292564003845 Walker A/P-loop; other site 292564003846 ATP binding site [chemical binding]; other site 292564003847 Q-loop/lid; other site 292564003848 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 292564003849 ABC transporter; Region: ABC_tran_2; pfam12848 292564003850 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 292564003851 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 292564003852 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 292564003853 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 292564003854 protein binding site [polypeptide binding]; other site 292564003855 Protein of unknown function (DUF2973); Region: DUF2973; pfam11189 292564003856 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 292564003857 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 292564003858 ATP binding site [chemical binding]; other site 292564003859 putative Mg++ binding site [ion binding]; other site 292564003860 helicase superfamily c-terminal domain; Region: HELICc; smart00490 292564003861 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 292564003862 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 292564003863 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 292564003864 light-harvesting-like protein 3; Provisional; Region: PLN00014 292564003865 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 292564003866 generic binding surface I; other site 292564003867 generic binding surface II; other site 292564003868 Exonuclease VII, large subunit; Region: Exonuc_VII_L; pfam02601 292564003869 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 292564003870 Nucleolar RNA-binding protein, Nop10p family; Region: Nop10p; cl00977 292564003871 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 292564003872 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 292564003873 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 292564003874 interchain domain interface [polypeptide binding]; other site 292564003875 intrachain domain interface; other site 292564003876 Qi binding site; other site 292564003877 Qo binding site; other site 292564003878 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 292564003879 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 292564003880 Qi binding site; other site 292564003881 intrachain domain interface; other site 292564003882 interchain domain interface [polypeptide binding]; other site 292564003883 heme bH binding site [chemical binding]; other site 292564003884 heme bL binding site [chemical binding]; other site 292564003885 Qo binding site; other site 292564003886 carboxyl-terminal processing protease; Provisional; Region: PLN00049 292564003887 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 292564003888 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 292564003889 protein binding site [polypeptide binding]; other site 292564003890 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 292564003891 Catalytic dyad [active] 292564003892 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 292564003893 HD domain; Region: HD; pfam01966 292564003894 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 292564003895 Chromate transporter; Region: Chromate_transp; pfam02417 292564003896 Chromate transporter; Region: Chromate_transp; pfam02417 292564003897 Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar1_1; cd09127 292564003898 PLD-like domain; Region: PLDc_2; pfam13091 292564003899 putative active site [active] 292564003900 putative catalytic site [active] 292564003901 Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar1_2; cd09128 292564003902 PLD-like domain; Region: PLDc_2; pfam13091 292564003903 putative active site [active] 292564003904 putative catalytic site [active] 292564003905 septum site-determining protein MinD; Region: minD_bact; TIGR01968 292564003906 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 292564003907 P-loop; other site 292564003908 ADP binding residues [chemical binding]; other site 292564003909 Switch I; other site 292564003910 Switch II; other site 292564003911 cell division topological specificity factor MinE; Provisional; Region: PRK13988 292564003912 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 292564003913 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 292564003914 DNA binding residues [nucleotide binding] 292564003915 dimerization interface [polypeptide binding]; other site 292564003916 Predicted membrane protein [Function unknown]; Region: COG2119 292564003917 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 292564003918 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 292564003919 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 292564003920 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 292564003921 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 292564003922 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 292564003923 DNA protecting protein DprA; Region: dprA; TIGR00732 292564003924 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 292564003925 active site 292564003926 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 292564003927 Ligand Binding Site [chemical binding]; other site 292564003928 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 292564003929 Ligand Binding Site [chemical binding]; other site 292564003930 photosystem II reaction center protein M; Provisional; Region: psbM; PRK04989 292564003931 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 292564003932 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 292564003933 catalytic loop [active] 292564003934 iron binding site [ion binding]; other site 292564003935 photosystem II chlorophyll-binding protein CP47; Region: PS_II_CP47; TIGR03039 292564003936 photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875 292564003937 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 292564003938 ATP cone domain; Region: ATP-cone; pfam03477 292564003939 30S ribosomal protein S1; Reviewed; Region: PRK07400 292564003940 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 292564003941 RNA binding site [nucleotide binding]; other site 292564003942 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 292564003943 RNA binding site [nucleotide binding]; other site 292564003944 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 292564003945 RNA binding site [nucleotide binding]; other site 292564003946 phosphoglycolate phosphatase; Provisional; Region: PRK13222 292564003947 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 292564003948 motif II; other site 292564003949 S-adenosylmethionine synthetase; Validated; Region: PRK05250 292564003950 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 292564003951 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 292564003952 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 292564003953 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 292564003954 nucleotide binding site [chemical binding]; other site 292564003955 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 292564003956 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 292564003957 comF family protein; Region: comF; TIGR00201 292564003958 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 292564003959 active site 292564003960 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 292564003961 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 292564003962 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 292564003963 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 292564003964 Phycobilisome protein; Region: Phycobilisome; cl08227 292564003965 Phycobilisome protein; Region: Phycobilisome; cl08227 292564003966 HEAT repeats; Region: HEAT_2; pfam13646 292564003967 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 292564003968 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 292564003969 Low molecular weight phosphatase family; Region: LMWPc; cd00115 292564003970 active site 292564003971 bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477 292564003972 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 292564003973 active site 292564003974 nucleotide binding site [chemical binding]; other site 292564003975 HIGH motif; other site 292564003976 KMSKS motif; other site 292564003977 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 292564003978 CMP-binding site; other site 292564003979 The sites determining sugar specificity; other site 292564003980 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 292564003981 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 292564003982 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 292564003983 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 292564003984 dimerization interface [polypeptide binding]; other site 292564003985 putative ATP binding site [chemical binding]; other site 292564003986 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 292564003987 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 292564003988 active site 292564003989 catalytic tetrad [active] 292564003990 Methyltransferase domain; Region: Methyltransf_23; pfam13489 292564003991 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292564003992 S-adenosylmethionine binding site [chemical binding]; other site 292564003993 acetaldehyde dehydrogenase; Validated; Region: PRK08300 292564003994 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 292564003995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 292564003996 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 292564003997 catalytic site [active] 292564003998 putative active site [active] 292564003999 putative substrate binding site [chemical binding]; other site 292564004000 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 292564004001 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 292564004002 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 292564004003 Domain of unknown function DUF59; Region: DUF59; pfam01883 292564004004 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 292564004005 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 292564004006 adaptive-response sensory kinase; Validated; Region: PRK09303 292564004007 PsaD; Region: PsaD; pfam02531 292564004008 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 292564004009 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 292564004010 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 292564004011 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 292564004012 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 292564004013 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 292564004014 recombination protein F; Reviewed; Region: recF; PRK00064 292564004015 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292564004016 Walker A/P-loop; other site 292564004017 ATP binding site [chemical binding]; other site 292564004018 Q-loop/lid; other site 292564004019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292564004020 ABC transporter signature motif; other site 292564004021 Walker B; other site 292564004022 D-loop; other site 292564004023 H-loop/switch region; other site 292564004024 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK02770 292564004025 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 292564004026 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 292564004027 Ligand Binding Site [chemical binding]; other site 292564004028 hypothetical protein; Validated; Region: PRK07413 292564004029 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 292564004030 Walker A motif; other site 292564004031 homodimer interface [polypeptide binding]; other site 292564004032 ATP binding site [chemical binding]; other site 292564004033 hydroxycobalamin binding site [chemical binding]; other site 292564004034 Walker B motif; other site 292564004035 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 292564004036 Ion channel; Region: Ion_trans_2; pfam07885 292564004037 hypothetical protein; Validated; Region: PRK07411 292564004038 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 292564004039 ATP binding site [chemical binding]; other site 292564004040 substrate interface [chemical binding]; other site 292564004041 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 292564004042 active site residue [active] 292564004043 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 292564004044 MPN+ (JAMM) motif; other site 292564004045 Zinc-binding site [ion binding]; other site 292564004046 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 292564004047 Fructosamine kinase; Region: Fructosamin_kin; cl17579 292564004048 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 292564004049 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 292564004050 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 292564004051 trimer interface [polypeptide binding]; other site 292564004052 putative Zn binding site [ion binding]; other site 292564004053 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 292564004054 GSH binding site [chemical binding]; other site 292564004055 catalytic residues [active] 292564004056 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 292564004057 Mechanosensitive ion channel; Region: MS_channel; pfam00924 292564004058 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 292564004059 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292564004060 Walker A/P-loop; other site 292564004061 ATP binding site [chemical binding]; other site 292564004062 Q-loop/lid; other site 292564004063 ABC transporter signature motif; other site 292564004064 Walker B; other site 292564004065 D-loop; other site 292564004066 H-loop/switch region; other site 292564004067 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 292564004068 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 292564004069 ATP-grasp domain; Region: ATP-grasp_4; cl17255 292564004070 Domain of unknown function (DUF389); Region: DUF389; pfam04087 292564004071 PBP superfamily domain; Region: PBP_like_2; cl17296 292564004072 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 292564004073 Sodium Bile acid symporter family; Region: SBF; cl17470 292564004074 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 292564004075 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 292564004076 HSP70 interaction site [polypeptide binding]; other site 292564004077 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 292564004078 substrate binding site [polypeptide binding]; other site 292564004079 dimer interface [polypeptide binding]; other site 292564004080 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 292564004081 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 292564004082 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 292564004083 putative active site [active] 292564004084 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 292564004085 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 292564004086 SAP domain; Region: SAP; cl02640 292564004087 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 292564004088 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 292564004089 oligomeric interface; other site 292564004090 putative active site [active] 292564004091 homodimer interface [polypeptide binding]; other site 292564004092 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 292564004093 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 292564004094 oligomeric interface; other site 292564004095 putative active site [active] 292564004096 homodimer interface [polypeptide binding]; other site 292564004097 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 292564004098 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 292564004099 metal ion-dependent adhesion site (MIDAS); other site 292564004100 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 292564004101 DNA binding residues [nucleotide binding] 292564004102 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 292564004103 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 292564004104 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 292564004105 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 292564004106 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765 292564004107 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 292564004108 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 292564004109 putative active site [active] 292564004110 metal binding site [ion binding]; metal-binding site 292564004111 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 292564004112 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 292564004113 motif II; other site 292564004114 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 292564004115 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 292564004116 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 292564004117 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292564004118 dimer interface [polypeptide binding]; other site 292564004119 phosphorylation site [posttranslational modification] 292564004120 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292564004121 ATP binding site [chemical binding]; other site 292564004122 Mg2+ binding site [ion binding]; other site 292564004123 G-X-G motif; other site 292564004124 Response regulator receiver domain; Region: Response_reg; pfam00072 292564004125 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292564004126 active site 292564004127 phosphorylation site [posttranslational modification] 292564004128 intermolecular recognition site; other site 292564004129 dimerization interface [polypeptide binding]; other site 292564004130 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 292564004131 GAF domain; Region: GAF; pfam01590 292564004132 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 292564004133 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 292564004134 active site residue [active] 292564004135 Cupin domain; Region: Cupin_2; cl17218 292564004136 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 292564004137 trimer interface [polypeptide binding]; other site 292564004138 active site 292564004139 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 292564004140 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 292564004141 putative NAD(P) binding site [chemical binding]; other site 292564004142 putative substrate binding site [chemical binding]; other site 292564004143 catalytic Zn binding site [ion binding]; other site 292564004144 structural Zn binding site [ion binding]; other site 292564004145 dimer interface [polypeptide binding]; other site 292564004146 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 292564004147 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 292564004148 acyl-activating enzyme (AAE) consensus motif; other site 292564004149 AMP binding site [chemical binding]; other site 292564004150 active site 292564004151 CoA binding site [chemical binding]; other site 292564004152 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 292564004153 PemK-like protein; Region: PemK; pfam02452 292564004154 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 292564004155 Protein of unknown function DUF86; Region: DUF86; pfam01934 292564004156 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 292564004157 active site 292564004158 NTP binding site [chemical binding]; other site 292564004159 metal binding triad [ion binding]; metal-binding site 292564004160 Uncharacterized conserved protein [Function unknown]; Region: COG2361 292564004161 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 292564004162 active site 292564004163 NTP binding site [chemical binding]; other site 292564004164 metal binding triad [ion binding]; metal-binding site 292564004165 antibiotic binding site [chemical binding]; other site 292564004166 putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574 292564004167 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 292564004168 oligomeric interface; other site 292564004169 putative active site [active] 292564004170 homodimer interface [polypeptide binding]; other site 292564004171 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 292564004172 Protein of unknown function (DUF497); Region: DUF497; pfam04365 292564004173 Putative addiction module component; Region: Unstab_antitox; pfam09720 292564004174 HNH endonuclease; Region: HNH_2; pfam13391 292564004175 Protein of unknown function (DUF497); Region: DUF497; pfam04365 292564004176 TIGR02646 family protein; Region: TIGR02646 292564004177 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292564004178 Walker A/P-loop; other site 292564004179 ATP binding site [chemical binding]; other site 292564004180 AAA domain; Region: AAA_21; pfam13304 292564004181 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292564004182 ABC transporter signature motif; other site 292564004183 Walker B; other site 292564004184 D-loop; other site 292564004185 H-loop/switch region; other site 292564004186 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 292564004187 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 292564004188 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 292564004189 HsdM N-terminal domain; Region: HsdM_N; pfam12161 292564004190 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 292564004191 Methyltransferase domain; Region: Methyltransf_26; pfam13659 292564004192 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 292564004193 oligomeric interface; other site 292564004194 putative active site [active] 292564004195 homodimer interface [polypeptide binding]; other site 292564004196 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 292564004197 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 292564004198 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 292564004199 ATP binding site [chemical binding]; other site 292564004200 putative Mg++ binding site [ion binding]; other site 292564004201 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 292564004202 nucleotide binding region [chemical binding]; other site 292564004203 ATP-binding site [chemical binding]; other site 292564004204 Protein of unknown function DUF262; Region: DUF262; pfam03235 292564004205 Uncharacterized conserved protein [Function unknown]; Region: COG1479 292564004206 Uncharacterized conserved protein [Function unknown]; Region: COG3472 292564004207 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 292564004208 YcfA-like protein; Region: YcfA; cl00752 292564004209 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 292564004210 oligomeric interface; other site 292564004211 putative active site [active] 292564004212 homodimer interface [polypeptide binding]; other site 292564004213 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 292564004214 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 292564004215 hypothetical protein; Validated; Region: PRK00029 292564004216 Uncharacterized conserved protein [Function unknown]; Region: COG0397 292564004217 Uncharacterized conserved protein [Function unknown]; Region: COG2442 292564004218 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 292564004219 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 292564004220 putative active site [active] 292564004221 FAD binding domain; Region: FAD_binding_3; pfam01494 292564004222 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 292564004223 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 292564004224 Beta-lactamase; Region: Beta-lactamase; pfam00144 292564004225 Predicted transcriptional regulators [Transcription]; Region: COG1695 292564004226 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 292564004227 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 292564004228 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 292564004229 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 292564004230 HlyD family secretion protein; Region: HlyD_3; pfam13437 292564004231 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 292564004232 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 292564004233 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 292564004234 active site 292564004235 metal binding site [ion binding]; metal-binding site 292564004236 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 292564004237 active site 292564004238 metal binding site [ion binding]; metal-binding site 292564004239 META domain; Region: META; pfam03724 292564004240 META domain; Region: META; pfam03724 292564004241 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 292564004242 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 292564004243 oligomer interface [polypeptide binding]; other site 292564004244 metal binding site [ion binding]; metal-binding site 292564004245 metal binding site [ion binding]; metal-binding site 292564004246 Cl binding site [ion binding]; other site 292564004247 aspartate ring; other site 292564004248 basic sphincter; other site 292564004249 putative hydrophobic gate; other site 292564004250 periplasmic entrance; other site 292564004251 arogenate dehydrogenase; Reviewed; Region: PRK07417 292564004252 prephenate dehydrogenase; Validated; Region: PRK08507 292564004253 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 292564004254 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 292564004255 Domain of unknown function (DUF1815); Region: DUF1815; pfam08844 292564004256 recombinase A; Provisional; Region: recA; PRK09354 292564004257 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 292564004258 hexamer interface [polypeptide binding]; other site 292564004259 Walker A motif; other site 292564004260 ATP binding site [chemical binding]; other site 292564004261 Walker B motif; other site 292564004262 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 292564004263 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 292564004264 Walker A motif; other site 292564004265 ATP binding site [chemical binding]; other site 292564004266 Walker B motif; other site 292564004267 R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645 292564004268 RxxxH motif; other site 292564004269 Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617 292564004270 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 292564004271 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 292564004272 NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909 292564004273 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 292564004274 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 292564004275 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 292564004276 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 292564004277 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 292564004278 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 292564004279 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 292564004280 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 292564004281 putative translocon binding site; other site 292564004282 protein-rRNA interface [nucleotide binding]; other site 292564004283 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 292564004284 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 292564004285 G-X-X-G motif; other site 292564004286 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 292564004287 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 292564004288 23S rRNA interface [nucleotide binding]; other site 292564004289 5S rRNA interface [nucleotide binding]; other site 292564004290 putative antibiotic binding site [chemical binding]; other site 292564004291 L25 interface [polypeptide binding]; other site 292564004292 L27 interface [polypeptide binding]; other site 292564004293 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 292564004294 23S rRNA interface [nucleotide binding]; other site 292564004295 putative translocon interaction site; other site 292564004296 signal recognition particle (SRP54) interaction site; other site 292564004297 L23 interface [polypeptide binding]; other site 292564004298 trigger factor interaction site; other site 292564004299 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 292564004300 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 292564004301 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 292564004302 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 292564004303 RNA binding site [nucleotide binding]; other site 292564004304 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 292564004305 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 292564004306 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 292564004307 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 292564004308 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 292564004309 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 292564004310 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 292564004311 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 292564004312 5S rRNA interface [nucleotide binding]; other site 292564004313 L27 interface [polypeptide binding]; other site 292564004314 23S rRNA interface [nucleotide binding]; other site 292564004315 L5 interface [polypeptide binding]; other site 292564004316 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 292564004317 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 292564004318 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 292564004319 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 292564004320 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 292564004321 SecY translocase; Region: SecY; pfam00344 292564004322 adenylate kinase; Provisional; Region: PRK14531 292564004323 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 292564004324 AMP-binding site [chemical binding]; other site 292564004325 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 292564004326 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 292564004327 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 292564004328 30S ribosomal protein S13; Region: bact_S13; TIGR03631 292564004329 30S ribosomal protein S11; Validated; Region: PRK05309 292564004330 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 292564004331 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 292564004332 alphaNTD homodimer interface [polypeptide binding]; other site 292564004333 alphaNTD - beta interaction site [polypeptide binding]; other site 292564004334 alphaNTD - beta' interaction site [polypeptide binding]; other site 292564004335 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 292564004336 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 292564004337 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 292564004338 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 292564004339 dimerization interface 3.5A [polypeptide binding]; other site 292564004340 active site 292564004341 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 292564004342 23S rRNA interface [nucleotide binding]; other site 292564004343 L3 interface [polypeptide binding]; other site 292564004344 ribosomal protein S9; Region: rps9; CHL00079 292564004345 ribosomal protein L31; Validated; Region: rpl31; CHL00136 292564004346 peptide chain release factor 1; Validated; Region: prfA; PRK00591 292564004347 This domain is found in peptide chain release factors; Region: PCRF; smart00937 292564004348 RF-1 domain; Region: RF-1; pfam00472 292564004349 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 292564004350 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 292564004351 active site 292564004352 alanine racemase; Reviewed; Region: alr; PRK00053 292564004353 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 292564004354 active site 292564004355 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 292564004356 dimer interface [polypeptide binding]; other site 292564004357 substrate binding site [chemical binding]; other site 292564004358 catalytic residues [active] 292564004359 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 292564004360 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 292564004361 NlpC/P60 family; Region: NLPC_P60; pfam00877 292564004362 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 292564004363 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 292564004364 Ligand binding site; other site 292564004365 Putative Catalytic site; other site 292564004366 DXD motif; other site 292564004367 photosystem I reaction center subunit VIII; Reviewed; Region: psaI; PRK11877 292564004368 photosystem I reaction center protein subunit XI; Provisional; Region: PRK00704 292564004369 Calx-beta domain; Region: Calx-beta; cl02522 292564004370 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 292564004371 generic binding surface II; other site 292564004372 generic binding surface I; other site 292564004373 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 292564004374 putative catalytic site [active] 292564004375 putative metal binding site [ion binding]; other site 292564004376 putative phosphate binding site [ion binding]; other site 292564004377 PhoD-like phosphatase; Region: PhoD; pfam09423 292564004378 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 292564004379 putative active site [active] 292564004380 putative metal binding site [ion binding]; other site 292564004381 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 292564004382 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 292564004383 active site 292564004384 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 292564004385 active site 292564004386 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 292564004387 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 292564004388 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 292564004389 Synechococcus sp. strain PCC 7942 PhoA and related proteins, N-terminal metallophosphatase domain; Region: MPP_PhoA_N; cd08162 292564004390 putative active site [active] 292564004391 putative metal binding site [ion binding]; other site 292564004392 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 292564004393 photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199 292564004394 photosystem I P700 chlorophyll a apoprotein A1; Provisional; Region: psaA; PRK13200 292564004395 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 292564004396 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 292564004397 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 292564004398 active site 292564004399 SAM binding site [chemical binding]; other site 292564004400 homodimer interface [polypeptide binding]; other site 292564004401 lipoyl synthase; Provisional; Region: PRK05481 292564004402 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 292564004403 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 292564004404 active site 292564004405 dimer interface [polypeptide binding]; other site 292564004406 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 292564004407 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 292564004408 active site 292564004409 FMN binding site [chemical binding]; other site 292564004410 substrate binding site [chemical binding]; other site 292564004411 3Fe-4S cluster binding site [ion binding]; other site 292564004412 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 292564004413 domain_subunit interface; other site 292564004414 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 292564004415 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 292564004416 S17 interaction site [polypeptide binding]; other site 292564004417 S8 interaction site; other site 292564004418 16S rRNA interaction site [nucleotide binding]; other site 292564004419 streptomycin interaction site [chemical binding]; other site 292564004420 23S rRNA interaction site [nucleotide binding]; other site 292564004421 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 292564004422 30S ribosomal protein S7; Validated; Region: PRK05302 292564004423 elongation factor G; Reviewed; Region: PRK00007 292564004424 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 292564004425 G1 box; other site 292564004426 putative GEF interaction site [polypeptide binding]; other site 292564004427 GTP/Mg2+ binding site [chemical binding]; other site 292564004428 Switch I region; other site 292564004429 G2 box; other site 292564004430 G3 box; other site 292564004431 Switch II region; other site 292564004432 G4 box; other site 292564004433 G5 box; other site 292564004434 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 292564004435 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 292564004436 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 292564004437 elongation factor Tu; Reviewed; Region: PRK00049 292564004438 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 292564004439 G1 box; other site 292564004440 GEF interaction site [polypeptide binding]; other site 292564004441 GTP/Mg2+ binding site [chemical binding]; other site 292564004442 Switch I region; other site 292564004443 G2 box; other site 292564004444 G3 box; other site 292564004445 Switch II region; other site 292564004446 G4 box; other site 292564004447 G5 box; other site 292564004448 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 292564004449 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 292564004450 Antibiotic Binding Site [chemical binding]; other site 292564004451 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 292564004452 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 292564004453 tocopherol O-methyltransferase; Region: PLN02244 292564004454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292564004455 S-adenosylmethionine binding site [chemical binding]; other site 292564004456 prephenate dehydratase; Provisional; Region: PRK11898 292564004457 Prephenate dehydratase; Region: PDT; pfam00800 292564004458 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 292564004459 putative L-Phe binding site [chemical binding]; other site 292564004460 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 292564004461 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 292564004462 RNA/DNA hybrid binding site [nucleotide binding]; other site 292564004463 active site 292564004464 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 292564004465 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 292564004466 homodimer interface [polypeptide binding]; other site 292564004467 oligonucleotide binding site [chemical binding]; other site 292564004468 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 292564004469 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 292564004470 B12 binding site [chemical binding]; other site 292564004471 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 292564004472 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 292564004473 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 292564004474 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 292564004475 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292564004476 homodimer interface [polypeptide binding]; other site 292564004477 catalytic residue [active] 292564004478 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 292564004479 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 292564004480 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 292564004481 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 292564004482 FeS/SAM binding site; other site 292564004483 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 292564004484 protein I interface; other site 292564004485 D2 interface; other site 292564004486 protein T interface; other site 292564004487 chlorophyll binding site; other site 292564004488 beta carotene binding site; other site 292564004489 pheophytin binding site; other site 292564004490 manganese-stabilizing polypeptide interface; other site 292564004491 CP43 interface; other site 292564004492 protein L interface; other site 292564004493 oxygen evolving complex binding site; other site 292564004494 bromide binding site; other site 292564004495 quinone binding site; other site 292564004496 Fe binding site [ion binding]; other site 292564004497 core light harvesting interface; other site 292564004498 cytochrome b559 alpha subunit interface; other site 292564004499 cytochrome c-550 interface; other site 292564004500 protein J interface; other site 292564004501 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 292564004502 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 292564004503 Tetramer interface [polypeptide binding]; other site 292564004504 active site 292564004505 FMN-binding site [chemical binding]; other site 292564004506 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 292564004507 active site 292564004508 intersubunit interface [polypeptide binding]; other site 292564004509 catalytic residue [active] 292564004510 FtsH Extracellular; Region: FtsH_ext; pfam06480 292564004511 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 292564004512 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 292564004513 Walker A motif; other site 292564004514 ATP binding site [chemical binding]; other site 292564004515 Walker B motif; other site 292564004516 arginine finger; other site 292564004517 Peptidase family M41; Region: Peptidase_M41; pfam01434 292564004518 ATP sulphurylase; Region: sopT; TIGR00339 292564004519 ATP-sulfurylase; Region: ATPS; cd00517 292564004520 active site 292564004521 HXXH motif; other site 292564004522 flexible loop; other site 292564004523 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; cl03326 292564004524 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 292564004525 Flavoprotein; Region: Flavoprotein; pfam02441 292564004526 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 292564004527 Protein of unknown function (DUF2555); Region: DUF2555; pfam10742 292564004528 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 292564004529 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 292564004530 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 292564004531 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 292564004532 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 292564004533 Creatinine amidohydrolase; Region: Creatininase; pfam02633 292564004534 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 292564004535 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 292564004536 Fatty acid desaturase; Region: FA_desaturase; pfam00487 292564004537 putative di-iron ligands [ion binding]; other site 292564004538 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 292564004539 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 292564004540 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 292564004541 active site 292564004542 HIGH motif; other site 292564004543 nucleotide binding site [chemical binding]; other site 292564004544 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 292564004545 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 292564004546 active site 292564004547 KMSKS motif; other site 292564004548 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 292564004549 tRNA binding surface [nucleotide binding]; other site 292564004550 anticodon binding site; other site 292564004551 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 292564004552 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 292564004553 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 292564004554 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 292564004555 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 292564004556 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 292564004557 Soluble P-type ATPase [General function prediction only]; Region: COG4087 292564004558 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 292564004559 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 292564004560 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 292564004561 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 292564004562 active site 292564004563 FMN binding site [chemical binding]; other site 292564004564 substrate binding site [chemical binding]; other site 292564004565 3Fe-4S cluster binding site [ion binding]; other site 292564004566 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 292564004567 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 292564004568 NAD(P) binding site [chemical binding]; other site 292564004569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 292564004570 SnoaL-like domain; Region: SnoaL_2; pfam12680 292564004571 PemK-like protein; Region: PemK; pfam02452 292564004572 Integrase core domain; Region: rve; pfam00665 292564004573 DDE domain; Region: DDE_Tnp_IS240; pfam13610 292564004574 Integrase core domain; Region: rve_3; pfam13683 292564004575 Transposase; Region: HTH_Tnp_1; cl17663 292564004576 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 292564004577 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 292564004578 Active site serine [active] 292564004579 Integrase core domain; Region: rve; pfam00665 292564004580 DDE domain; Region: DDE_Tnp_IS240; pfam13610 292564004581 Integrase core domain; Region: rve_3; pfam13683 292564004582 Transposase; Region: HTH_Tnp_1; cl17663 292564004583 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 292564004584 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 292564004585 Catalytic site; other site 292564004586 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 292564004587 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 292564004588 active site 292564004589 catalytic site [active] 292564004590 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 292564004591 Transposase; Region: DEDD_Tnp_IS110; pfam01548 292564004592 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 292564004593 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 292564004594 Homeodomain-like domain; Region: HTH_23; cl17451 292564004595 Winged helix-turn helix; Region: HTH_29; pfam13551 292564004596 Integrase core domain; Region: rve; pfam00665 292564004597 Integrase core domain; Region: rve_3; pfam13683 292564004598 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 292564004599 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 292564004600 active site 292564004601 catalytic site [active] 292564004602 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233 292564004603 putative active site [active] 292564004604 Zn binding site [ion binding]; other site 292564004605 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 292564004606 HsdM N-terminal domain; Region: HsdM_N; pfam12161 292564004607 Methyltransferase domain; Region: Methyltransf_26; pfam13659 292564004608 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 292564004609 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 292564004610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 292564004611 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 292564004612 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 292564004613 ATP binding site [chemical binding]; other site 292564004614 putative Mg++ binding site [ion binding]; other site 292564004615 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 292564004616 Divergent AAA domain; Region: AAA_4; pfam04326 292564004617 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 292564004618 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 292564004619 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 292564004620 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 292564004621 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 292564004622 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 292564004623 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 292564004624 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 292564004625 active site 292564004626 catalytic tetrad [active] 292564004627 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 292564004628 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 292564004629 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 292564004630 active site 292564004631 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 292564004632 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 292564004633 FIST N domain; Region: FIST; pfam08495 292564004634 FIST C domain; Region: FIST_C; pfam10442 292564004635 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 292564004636 O-Antigen ligase; Region: Wzy_C; cl04850 292564004637 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 292564004638 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 292564004639 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 292564004640 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 292564004641 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 292564004642 MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044 292564004643 Predicted amidohydrolase [General function prediction only]; Region: COG0388 292564004644 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 292564004645 putative active site [active] 292564004646 catalytic triad [active] 292564004647 putative dimer interface [polypeptide binding]; other site 292564004648 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 292564004649 putative N-acetyltransferase, MSMEG_0567 N-terminal domain family; Region: MSMEG_0567_GNAT; TIGR04045 292564004650 AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049 292564004651 AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192 292564004652 dimerization interface [polypeptide binding]; other site 292564004653 putative ATP binding site [chemical binding]; other site 292564004654 MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042 292564004655 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 292564004656 CsbD-like; Region: CsbD; pfam05532 292564004657 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 292564004658 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 292564004659 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 292564004660 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 292564004661 DNA binding residues [nucleotide binding] 292564004662 Predicted membrane protein [Function unknown]; Region: COG2323 292564004663 Protein of unknown function (DUF3122); Region: DUF3122; pfam11320 292564004664 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 292564004665 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 292564004666 PIN domain; Region: PIN; pfam01850 292564004667 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 292564004668 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 292564004669 putative active site [active] 292564004670 homotetrameric interface [polypeptide binding]; other site 292564004671 metal binding site [ion binding]; metal-binding site 292564004672 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 292564004673 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 292564004674 putative active site [active] 292564004675 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 292564004676 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 292564004677 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 292564004678 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 292564004679 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 292564004680 active site residue [active] 292564004681 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 292564004682 active site residue [active] 292564004683 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 292564004684 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292564004685 S-adenosylmethionine binding site [chemical binding]; other site 292564004686 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 292564004687 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 292564004688 active site 292564004689 metal binding site [ion binding]; metal-binding site 292564004690 DNA binding site [nucleotide binding] 292564004691 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 292564004692 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292564004693 AAA domain; Region: AAA_23; pfam13476 292564004694 Walker A/P-loop; other site 292564004695 ATP binding site [chemical binding]; other site 292564004696 Q-loop/lid; other site 292564004697 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292564004698 ABC transporter signature motif; other site 292564004699 Walker B; other site 292564004700 D-loop; other site 292564004701 H-loop/switch region; other site 292564004702 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12567 292564004703 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 292564004704 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334 292564004705 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 292564004706 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 292564004707 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 292564004708 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 292564004709 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317 292564004710 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 292564004711 active site 292564004712 substrate binding site [chemical binding]; other site 292564004713 metal binding site [ion binding]; metal-binding site 292564004714 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 292564004715 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 292564004716 N-acetyl-D-glucosamine binding site [chemical binding]; other site 292564004717 catalytic residue [active] 292564004718 NIL domain; Region: NIL; pfam09383 292564004719 4Fe-4S binding domain; Region: Fer4; pfam00037 292564004720 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 292564004721 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 292564004722 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 292564004723 thymidylate synthase, flavin-dependent; Region: thyX; TIGR02170 292564004724 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 292564004725 substrate binding pocket [chemical binding]; other site 292564004726 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 292564004727 membrane-bound complex binding site; other site 292564004728 hinge residues; other site 292564004729 PGAP1-like protein; Region: PGAP1; pfam07819 292564004730 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 292564004731 dimer interface [polypeptide binding]; other site 292564004732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 292564004733 active site 292564004734 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 292564004735 phosphorylation site [posttranslational modification] 292564004736 intermolecular recognition site; other site 292564004737 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 292564004738 DNA binding residues [nucleotide binding] 292564004739 dimerization interface [polypeptide binding]; other site 292564004740 endoglucanase; Region: PLN02308 292564004741 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 292564004742 CBD_II domain; Region: CBD_II; smart00637 292564004743 PemK-like protein; Region: PemK; pfam02452 292564004744 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 292564004745 CAAX protease self-immunity; Region: Abi; pfam02517 292564004746 TPR repeat; Region: TPR_11; pfam13414 292564004747 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 292564004748 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 292564004749 HlyD family secretion protein; Region: HlyD_3; pfam13437 292564004750 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 292564004751 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 292564004752 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 292564004753 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 292564004754 Walker A/P-loop; other site 292564004755 ATP binding site [chemical binding]; other site 292564004756 Q-loop/lid; other site 292564004757 ABC transporter signature motif; other site 292564004758 Walker B; other site 292564004759 D-loop; other site 292564004760 H-loop/switch region; other site 292564004761 Cupin domain; Region: Cupin_2; cl17218 292564004762 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 292564004763 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 292564004764 Coenzyme A binding pocket [chemical binding]; other site 292564004765 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 292564004766 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 292564004767 Walker A/P-loop; other site 292564004768 ATP binding site [chemical binding]; other site 292564004769 Q-loop/lid; other site 292564004770 ABC transporter signature motif; other site 292564004771 Walker B; other site 292564004772 D-loop; other site 292564004773 H-loop/switch region; other site 292564004774 DevC protein; Region: devC; TIGR01185 292564004775 FtsX-like permease family; Region: FtsX; pfam02687 292564004776 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 292564004777 HlyD family secretion protein; Region: HlyD_3; pfam13437 292564004778 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 292564004779 putative active site [active] 292564004780 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 292564004781 active site 292564004782 NTP binding site [chemical binding]; other site 292564004783 metal binding triad [ion binding]; metal-binding site 292564004784 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 292564004785 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 292564004786 putative substrate translocation pore; other site 292564004787 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 292564004788 Protein of unknown function (DUF429); Region: DUF429; pfam04250 292564004789 AAA domain; Region: AAA_18; pfam13238 292564004790 AAA domain; Region: AAA_17; pfam13207 292564004791 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 292564004792 putative active site pocket [active] 292564004793 dimerization interface [polypeptide binding]; other site 292564004794 putative catalytic residue [active] 292564004795 AAA domain; Region: AAA_21; pfam13304 292564004796 putative transposase OrfB; Reviewed; Region: PHA02517 292564004797 HTH-like domain; Region: HTH_21; pfam13276 292564004798 Integrase core domain; Region: rve; pfam00665 292564004799 Integrase core domain; Region: rve_3; pfam13683 292564004800 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 292564004801 Transposase; Region: HTH_Tnp_1; pfam01527 292564004802 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 292564004803 putative catalytic site [active] 292564004804 putative metal binding site [ion binding]; other site 292564004805 putative phosphate binding site [ion binding]; other site 292564004806 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 292564004807 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 292564004808 Putative transposase; Region: Y2_Tnp; pfam04986 292564004809 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 292564004810 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 292564004811 active site 292564004812 DNA binding site [nucleotide binding] 292564004813 Int/Topo IB signature motif; other site 292564004814 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 292564004815 trimer interface [polypeptide binding]; other site 292564004816 active site 292564004817 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 292564004818 ribonuclease PH; Reviewed; Region: rph; PRK00173 292564004819 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 292564004820 oligomer interface [polypeptide binding]; other site 292564004821 RNA binding site [nucleotide binding]; other site 292564004822 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 292564004823 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 292564004824 ligand binding site [chemical binding]; other site 292564004825 flexible hinge region; other site 292564004826 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 292564004827 putative switch regulator; other site 292564004828 non-specific DNA interactions [nucleotide binding]; other site 292564004829 DNA binding site [nucleotide binding] 292564004830 sequence specific DNA binding site [nucleotide binding]; other site 292564004831 putative cAMP binding site [chemical binding]; other site 292564004832 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 292564004833 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 292564004834 Protein of unknown function (DUF3146); Region: DUF3146; pfam11344 292564004835 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 292564004836 putative active site [active] 292564004837 catalytic residue [active] 292564004838 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 292564004839 photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624 292564004840 photosystem II reaction center protein N; Provisional; Region: psbN; PRK13183 292564004841 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 292564004842 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 292564004843 active site 292564004844 catalytic site [active] 292564004845 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 292564004846 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 292564004847 photosystem II reaction center I protein I; Provisional; Region: psbI; PRK02655 292564004848 Protein of unknown function (DUF3769); Region: DUF3769; pfam12600 292564004849 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 292564004850 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 292564004851 substrate binding site [chemical binding]; other site 292564004852 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 292564004853 substrate binding site [chemical binding]; other site 292564004854 ligand binding site [chemical binding]; other site 292564004855 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 292564004856 competence damage-inducible protein A; Provisional; Region: PRK00549 292564004857 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 292564004858 putative MPT binding site; other site 292564004859 Competence-damaged protein; Region: CinA; pfam02464 292564004860 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 292564004861 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 292564004862 Mg++ binding site [ion binding]; other site 292564004863 putative catalytic motif [active] 292564004864 substrate binding site [chemical binding]; other site 292564004865 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 292564004866 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 292564004867 dimer interface [polypeptide binding]; other site 292564004868 active site 292564004869 glycine-pyridoxal phosphate binding site [chemical binding]; other site 292564004870 folate binding site [chemical binding]; other site 292564004871 2TM domain; Region: 2TM; pfam13239 292564004872 Protein of unknown function (DUF3181); Region: DUF3181; pfam11378 292564004873 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 292564004874 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 292564004875 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 292564004876 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 292564004877 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 292564004878 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371 292564004879 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 292564004880 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 292564004881 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 292564004882 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 292564004883 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 292564004884 purine monophosphate binding site [chemical binding]; other site 292564004885 dimer interface [polypeptide binding]; other site 292564004886 putative catalytic residues [active] 292564004887 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 292564004888 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 292564004889 putative hydrolase; Provisional; Region: PRK11460 292564004890 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 292564004891 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 292564004892 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292564004893 phosphorylation site [posttranslational modification] 292564004894 dimer interface [polypeptide binding]; other site 292564004895 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292564004896 Mg2+ binding site [ion binding]; other site 292564004897 G-X-G motif; other site 292564004898 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 292564004899 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 292564004900 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 292564004901 Photosystem II 4 kDa reaction centre component; Region: PsbK; cl03641 292564004902 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 292564004903 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 292564004904 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 292564004905 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 292564004906 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 292564004907 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 292564004908 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 292564004909 Domain of unknown function DUF21; Region: DUF21; pfam01595 292564004910 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 292564004911 Transporter associated domain; Region: CorC_HlyC; smart01091 292564004912 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 292564004913 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 292564004914 active site 292564004915 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 292564004916 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 292564004917 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 292564004918 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 292564004919 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 292564004920 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 292564004921 RNase_H superfamily; Region: RNase_H_2; pfam13482 292564004922 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 292564004923 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 292564004924 active site 292564004925 substrate binding site [chemical binding]; other site 292564004926 metal binding site [ion binding]; metal-binding site 292564004927 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 292564004928 active site 292564004929 dimerization interface [polypeptide binding]; other site 292564004930 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 292564004931 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 292564004932 Protein of unknown function (DUF563); Region: DUF563; pfam04577 292564004933 YCII-related domain; Region: YCII; cl00999 292564004934 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 292564004935 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 292564004936 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 292564004937 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 292564004938 imidazoleglycerol-phosphate dehydratase; Region: PLN02800 292564004939 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 292564004940 putative active site pocket [active] 292564004941 4-fold oligomerization interface [polypeptide binding]; other site 292564004942 metal binding residues [ion binding]; metal-binding site 292564004943 3-fold/trimer interface [polypeptide binding]; other site 292564004944 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 292564004945 active site clefts [active] 292564004946 zinc binding site [ion binding]; other site 292564004947 dimer interface [polypeptide binding]; other site 292564004948 Protein of unknown function (DUF563); Region: DUF563; pfam04577 292564004949 enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370 292564004950 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 292564004951 NAD binding site [chemical binding]; other site 292564004952 homotetramer interface [polypeptide binding]; other site 292564004953 homodimer interface [polypeptide binding]; other site 292564004954 substrate binding site [chemical binding]; other site 292564004955 active site 292564004956 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 292564004957 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 292564004958 putative catalytic residue [active] 292564004959 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 292564004960 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 292564004961 inhibitor-cofactor binding pocket; inhibition site 292564004962 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292564004963 catalytic residue [active] 292564004964 deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556 292564004965 DNA photolyase; Region: DNA_photolyase; pfam00875 292564004966 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 292564004967 dimer interface [polypeptide binding]; other site 292564004968 ADP-ribose binding site [chemical binding]; other site 292564004969 active site 292564004970 nudix motif; other site 292564004971 metal binding site [ion binding]; metal-binding site 292564004972 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 292564004973 catalytic center binding site [active] 292564004974 ATP binding site [chemical binding]; other site 292564004975 Methyltransferase domain; Region: Methyltransf_23; pfam13489 292564004976 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292564004977 S-adenosylmethionine binding site [chemical binding]; other site 292564004978 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 292564004979 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 292564004980 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 292564004981 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 292564004982 metal ion-dependent adhesion site (MIDAS); other site 292564004983 Substrate binding subunit of ER-derived-lipid transporter; Provisional; Region: PLN03094 292564004984 mce related protein; Region: MCE; pfam02470 292564004985 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 292564004986 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292564004987 Walker A/P-loop; other site 292564004988 ATP binding site [chemical binding]; other site 292564004989 Q-loop/lid; other site 292564004990 ABC transporter signature motif; other site 292564004991 Walker B; other site 292564004992 D-loop; other site 292564004993 H-loop/switch region; other site 292564004994 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 292564004995 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 292564004996 phosphate binding site [ion binding]; other site 292564004997 putative substrate binding pocket [chemical binding]; other site 292564004998 dimer interface [polypeptide binding]; other site 292564004999 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292564005000 Methyltransferase domain; Region: Methyltransf_31; pfam13847 292564005001 S-adenosylmethionine binding site [chemical binding]; other site 292564005002 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 292564005003 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 292564005004 Transposase; Region: HTH_Tnp_1; pfam01527 292564005005 Rhamnan synthesis protein F; Region: RgpF; pfam05045 292564005006 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 292564005007 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 292564005008 NADH dehydrogenase subunit 3; Region: ndhC; CHL00022 292564005009 Rubredoxin [Energy production and conversion]; Region: COG1773 292564005010 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 292564005011 iron binding site [ion binding]; other site 292564005012 Ycf48-like protein; Provisional; Region: PRK13684 292564005013 cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557 292564005014 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283 292564005015 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284 292564005016 cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561 292564005017 PsbL protein; Region: PsbL; pfam02419 292564005018 photosystem II reaction center protein J; Provisional; Region: PRK02565 292564005019 histidyl-tRNA synthetase; Region: hisS; TIGR00442 292564005020 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 292564005021 dimer interface [polypeptide binding]; other site 292564005022 motif 1; other site 292564005023 active site 292564005024 motif 2; other site 292564005025 motif 3; other site 292564005026 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 292564005027 anticodon binding site; other site 292564005028 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 292564005029 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 292564005030 putative NAD(P) binding site [chemical binding]; other site 292564005031 active site 292564005032 putative substrate binding site [chemical binding]; other site 292564005033 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 292564005034 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 292564005035 NAD binding site [chemical binding]; other site 292564005036 putative substrate binding site 2 [chemical binding]; other site 292564005037 putative substrate binding site 1 [chemical binding]; other site 292564005038 active site 292564005039 probable UDP-glucose 6-dehydrogenase; Region: PLN02353 292564005040 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 292564005041 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 292564005042 UDP-glucose 4-epimerase; Region: PLN02240 292564005043 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 292564005044 NAD binding site [chemical binding]; other site 292564005045 homodimer interface [polypeptide binding]; other site 292564005046 active site 292564005047 substrate binding site [chemical binding]; other site 292564005048 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 292564005049 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 292564005050 active site 292564005051 NTP binding site [chemical binding]; other site 292564005052 metal binding triad [ion binding]; metal-binding site 292564005053 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 292564005054 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 292564005055 Probable Catalytic site; other site 292564005056 metal-binding site 292564005057 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 292564005058 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 292564005059 active site 292564005060 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 292564005061 Part of AAA domain; Region: AAA_19; pfam13245 292564005062 Family description; Region: UvrD_C_2; pfam13538 292564005063 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 292564005064 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292564005065 Walker A/P-loop; other site 292564005066 ATP binding site [chemical binding]; other site 292564005067 Q-loop/lid; other site 292564005068 ABC transporter signature motif; other site 292564005069 Walker B; other site 292564005070 D-loop; other site 292564005071 H-loop/switch region; other site 292564005072 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 292564005073 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 292564005074 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 292564005075 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 292564005076 heme binding pocket [chemical binding]; other site 292564005077 heme ligand [chemical binding]; other site 292564005078 isocitrate dehydrogenase; Validated; Region: PRK07362 292564005079 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 292564005080 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 292564005081 Cysteine-rich domain; Region: CCG; pfam02754 292564005082 Cysteine-rich domain; Region: CCG; pfam02754 292564005083 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 292564005084 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 292564005085 FAD binding domain; Region: FAD_binding_4; pfam01565 292564005086 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 292564005087 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 292564005088 active site 292564005089 catalytic residues [active] 292564005090 Acyltransferase family; Region: Acyl_transf_3; pfam01757 292564005091 Acyltransferase family; Region: Acyl_transf_3; pfam01757 292564005092 hydrolase, alpha/beta fold family protein; Region: PLN02824 292564005093 Partial alpha/beta-hydrolase lipase region; Region: Abhydro_lipase; pfam04083 292564005094 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 292564005095 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 292564005096 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 292564005097 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 292564005098 homodimer interface [polypeptide binding]; other site 292564005099 active site pocket [active] 292564005100 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 292564005101 dimerization interface [polypeptide binding]; other site 292564005102 active site 292564005103 metal binding site [ion binding]; metal-binding site 292564005104 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 292564005105 Protein of unknown function (DUF3252); Region: DUF3252; pfam11623 292564005106 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 292564005107 RimM N-terminal domain; Region: RimM; pfam01782 292564005108 PRC-barrel domain; Region: PRC; pfam05239 292564005109 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 292564005110 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 292564005111 Substrate binding site; other site 292564005112 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 292564005113 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 292564005114 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 292564005115 glutaminase active site [active] 292564005116 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 292564005117 dimer interface [polypeptide binding]; other site 292564005118 active site 292564005119 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 292564005120 dimer interface [polypeptide binding]; other site 292564005121 active site 292564005122 photosystem I subunit VII; Region: psaC; CHL00065 292564005123 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 292564005124 acyl carrier protein; Provisional; Region: acpP; PRK00982 292564005125 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 292564005126 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 292564005127 dimer interface [polypeptide binding]; other site 292564005128 active site 292564005129 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 292564005130 transketolase; Region: PLN02790 292564005131 TPP-binding site [chemical binding]; other site 292564005132 dimer interface [polypeptide binding]; other site 292564005133 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 292564005134 PYR/PP interface [polypeptide binding]; other site 292564005135 dimer interface [polypeptide binding]; other site 292564005136 TPP binding site [chemical binding]; other site 292564005137 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 292564005138 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 292564005139 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 292564005140 Ligand binding site; other site 292564005141 Putative Catalytic site; other site 292564005142 DXD motif; other site 292564005143 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 292564005144 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 292564005145 NAD(P) binding site [chemical binding]; other site 292564005146 active site 292564005147 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 292564005148 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 292564005149 NAD(P) binding site [chemical binding]; other site 292564005150 active site 292564005151 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 292564005152 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 292564005153 inhibitor-cofactor binding pocket; inhibition site 292564005154 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292564005155 catalytic residue [active] 292564005156 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 292564005157 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 292564005158 NAD(P) binding site [chemical binding]; other site 292564005159 active site 292564005160 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 292564005161 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 292564005162 substrate binding site; other site 292564005163 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 292564005164 HSP70 interaction site [polypeptide binding]; other site 292564005165 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 292564005166 putative metal binding site [ion binding]; other site 292564005167 Uncharacterized conserved protein [Function unknown]; Region: COG1432 292564005168 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 292564005169 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 292564005170 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 292564005171 active site residue [active] 292564005172 Sulphur transport; Region: Sulf_transp; pfam04143 292564005173 Predicted transporter component [General function prediction only]; Region: COG2391 292564005174 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 292564005175 Sulphur transport; Region: Sulf_transp; pfam04143 292564005176 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 292564005177 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 292564005178 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 292564005179 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 292564005180 metal binding site [ion binding]; metal-binding site 292564005181 dimer interface [polypeptide binding]; other site 292564005182 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292564005183 binding surface 292564005184 TPR motif; other site 292564005185 TPR repeat; Region: TPR_11; pfam13414 292564005186 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 292564005187 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 292564005188 Walker A motif; other site 292564005189 ATP binding site [chemical binding]; other site 292564005190 Walker B motif; other site 292564005191 arginine finger; other site 292564005192 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 292564005193 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 292564005194 SmpB-tmRNA interface; other site 292564005195 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 292564005196 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 292564005197 active site 292564005198 ATP binding site [chemical binding]; other site 292564005199 substrate binding site [chemical binding]; other site 292564005200 activation loop (A-loop); other site 292564005201 Bacteriophage phi-29 early protein GP16.7; Region: Phi-29_GP16_7; pfam06720 292564005202 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 292564005203 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 292564005204 dimer interface [polypeptide binding]; other site 292564005205 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292564005206 catalytic residue [active] 292564005207 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 292564005208 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 292564005209 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 292564005210 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 292564005211 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 292564005212 Uncharacterized conserved protein [Function unknown]; Region: COG1434 292564005213 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 292564005214 putative active site [active] 292564005215 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 292564005216 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 292564005217 putative anticodon binding site; other site 292564005218 dimer interface [polypeptide binding]; other site 292564005219 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 292564005220 motif 1; other site 292564005221 active site 292564005222 motif 2; other site 292564005223 motif 3; other site 292564005224 Ycf27; Reviewed; Region: orf27; CHL00148 292564005225 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292564005226 active site 292564005227 phosphorylation site [posttranslational modification] 292564005228 intermolecular recognition site; other site 292564005229 dimerization interface [polypeptide binding]; other site 292564005230 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 292564005231 DNA binding site [nucleotide binding] 292564005232 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 292564005233 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 292564005234 rod shape-determining protein MreC; Provisional; Region: PRK13922 292564005235 rod shape-determining protein MreC; Region: MreC; pfam04085 292564005236 rod shape-determining protein MreB; Provisional; Region: PRK13927 292564005237 MreB and similar proteins; Region: MreB_like; cd10225 292564005238 nucleotide binding site [chemical binding]; other site 292564005239 Mg binding site [ion binding]; other site 292564005240 putative protofilament interaction site [polypeptide binding]; other site 292564005241 RodZ interaction site [polypeptide binding]; other site 292564005242 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 292564005243 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 292564005244 dimer interface [polypeptide binding]; other site 292564005245 ssDNA binding site [nucleotide binding]; other site 292564005246 tetramer (dimer of dimers) interface [polypeptide binding]; other site 292564005247 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 292564005248 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 292564005249 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 292564005250 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 292564005251 Ligand binding site; other site 292564005252 Putative Catalytic site; other site 292564005253 DXD motif; other site 292564005254 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 292564005255 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 292564005256 homotetramer interface [polypeptide binding]; other site 292564005257 ligand binding site [chemical binding]; other site 292564005258 catalytic site [active] 292564005259 NAD binding site [chemical binding]; other site 292564005260 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 292564005261 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 292564005262 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 292564005263 minor groove reading motif; other site 292564005264 helix-hairpin-helix signature motif; other site 292564005265 substrate binding pocket [chemical binding]; other site 292564005266 active site 292564005267 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 292564005268 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 292564005269 active site 292564005270 8-oxo-dGMP binding site [chemical binding]; other site 292564005271 nudix motif; other site 292564005272 metal binding site [ion binding]; metal-binding site 292564005273 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 292564005274 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 292564005275 active site 292564005276 DNA binding site [nucleotide binding] 292564005277 Int/Topo IB signature motif; other site 292564005278 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 292564005279 Putative transposase; Region: Y2_Tnp; pfam04986 292564005280 Predicted transcriptional regulators [Transcription]; Region: COG1733 292564005281 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 292564005282 SCP-2 sterol transfer family; Region: SCP2; pfam02036 292564005283 MAPEG family; Region: MAPEG; pfam01124 292564005284 Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; pfam13759 292564005285 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 292564005286 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 292564005287 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 292564005288 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 292564005289 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 292564005290 DNA binding residues [nucleotide binding] 292564005291 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 292564005292 MgtE intracellular N domain; Region: MgtE_N; smart00924 292564005293 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 292564005294 Divalent cation transporter; Region: MgtE; pfam01769 292564005295 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 292564005296 catalytic residues [active] 292564005297 dimer interface [polypeptide binding]; other site 292564005298 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 292564005299 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292564005300 ATP binding site [chemical binding]; other site 292564005301 Mg2+ binding site [ion binding]; other site 292564005302 G-X-G motif; other site 292564005303 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 292564005304 anchoring element; other site 292564005305 dimer interface [polypeptide binding]; other site 292564005306 ATP binding site [chemical binding]; other site 292564005307 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 292564005308 active site 292564005309 putative metal-binding site [ion binding]; other site 292564005310 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 292564005311 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 292564005312 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 292564005313 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 292564005314 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 292564005315 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 292564005316 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 292564005317 Predicted transcriptional regulators [Transcription]; Region: COG1725 292564005318 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 292564005319 DNA-binding site [nucleotide binding]; DNA binding site 292564005320 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 292564005321 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 292564005322 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 292564005323 trimer interface [polypeptide binding]; other site 292564005324 active site 292564005325 substrate binding site [chemical binding]; other site 292564005326 CoA binding site [chemical binding]; other site 292564005327 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 292564005328 putative active site [active] 292564005329 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 292564005330 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 292564005331 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 292564005332 ATP binding site [chemical binding]; other site 292564005333 putative Mg++ binding site [ion binding]; other site 292564005334 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 292564005335 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 292564005336 Coenzyme A binding pocket [chemical binding]; other site 292564005337 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 292564005338 Bacterial sugar transferase; Region: Bac_transf; pfam02397 292564005339 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 292564005340 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 292564005341 NAD binding site [chemical binding]; other site 292564005342 homodimer interface [polypeptide binding]; other site 292564005343 active site 292564005344 substrate binding site [chemical binding]; other site 292564005345 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 292564005346 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 292564005347 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 292564005348 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 292564005349 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 292564005350 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 292564005351 NAD(P) binding site [chemical binding]; other site 292564005352 active site 292564005353 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 292564005354 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 292564005355 active site 292564005356 Methyltransferase domain; Region: Methyltransf_23; pfam13489 292564005357 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292564005358 S-adenosylmethionine binding site [chemical binding]; other site 292564005359 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 292564005360 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 292564005361 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 292564005362 active site 292564005363 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 292564005364 Cephalosporin hydroxylase; Region: CmcI; pfam04989 292564005365 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 292564005366 active site 292564005367 substrate binding site [chemical binding]; other site 292564005368 cosubstrate binding site; other site 292564005369 catalytic site [active] 292564005370 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 292564005371 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 292564005372 inhibitor-cofactor binding pocket; inhibition site 292564005373 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292564005374 catalytic residue [active] 292564005375 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 292564005376 Methyltransferase domain; Region: Methyltransf_23; pfam13489 292564005377 Methyltransferase domain; Region: Methyltransf_12; pfam08242 292564005378 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 292564005379 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 292564005380 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292564005381 S-adenosylmethionine binding site [chemical binding]; other site 292564005382 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 292564005383 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 292564005384 Walker A/P-loop; other site 292564005385 ATP binding site [chemical binding]; other site 292564005386 Q-loop/lid; other site 292564005387 ABC transporter signature motif; other site 292564005388 Walker B; other site 292564005389 D-loop; other site 292564005390 H-loop/switch region; other site 292564005391 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 292564005392 putative carbohydrate binding site [chemical binding]; other site 292564005393 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 292564005394 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 292564005395 photosystem II reaction center protein Z; Provisional; Region: psbZ; PRK02576 292564005396 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 292564005397 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 292564005398 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 292564005399 substrate binding site; other site 292564005400 tetramer interface; other site 292564005401 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 292564005402 homopentamer interface [polypeptide binding]; other site 292564005403 active site 292564005404 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 292564005405 MutS domain I; Region: MutS_I; pfam01624 292564005406 MutS domain II; Region: MutS_II; pfam05188 292564005407 MutS domain III; Region: MutS_III; pfam05192 292564005408 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 292564005409 Walker A/P-loop; other site 292564005410 ATP binding site [chemical binding]; other site 292564005411 Q-loop/lid; other site 292564005412 ABC transporter signature motif; other site 292564005413 Walker B; other site 292564005414 D-loop; other site 292564005415 H-loop/switch region; other site 292564005416 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 292564005417 Precorrin-8X methylmutase; Region: CbiC; pfam02570 292564005418 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 292564005419 DNA polymerase III subunit delta; Validated; Region: PRK07452 292564005420 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 292564005421 aspartate kinase; Provisional; Region: PRK07431 292564005422 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 292564005423 putative catalytic residues [active] 292564005424 putative nucleotide binding site [chemical binding]; other site 292564005425 putative aspartate binding site [chemical binding]; other site 292564005426 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 292564005427 putative allosteric regulatory site; other site 292564005428 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 292564005429 putative allosteric regulatory residue; other site 292564005430 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 292564005431 putative allosteric regulatory site; other site 292564005432 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 292564005433 putative allosteric regulatory residue; other site 292564005434 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 292564005435 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 292564005436 GAF domain; Region: GAF; pfam01590 292564005437 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 292564005438 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 292564005439 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 292564005440 excinuclease ABC subunit B; Provisional; Region: PRK05298 292564005441 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 292564005442 ATP binding site [chemical binding]; other site 292564005443 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 292564005444 nucleotide binding region [chemical binding]; other site 292564005445 ATP-binding site [chemical binding]; other site 292564005446 Ultra-violet resistance protein B; Region: UvrB; pfam12344 292564005447 UvrB/uvrC motif; Region: UVR; pfam02151 292564005448 Protein of unknown function (DUF561); Region: DUF561; pfam04481 292564005449 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 292564005450 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 292564005451 Ligand Binding Site [chemical binding]; other site 292564005452 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 292564005453 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 292564005454 Protein of unknown function (DUF432); Region: DUF432; cl01027 292564005455 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 292564005456 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 292564005457 dihydrodipicolinate synthase; Region: dapA; TIGR00674 292564005458 dimer interface [polypeptide binding]; other site 292564005459 active site 292564005460 catalytic residue [active] 292564005461 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 292564005462 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 292564005463 trigger factor; Region: tig; TIGR00115 292564005464 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 292564005465 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 292564005466 Clp protease; Region: CLP_protease; pfam00574 292564005467 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 292564005468 oligomer interface [polypeptide binding]; other site 292564005469 active site residues [active] 292564005470 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 292564005471 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 292564005472 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 292564005473 Walker A motif; other site 292564005474 ATP binding site [chemical binding]; other site 292564005475 Walker B motif; other site 292564005476 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 292564005477 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 292564005478 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 292564005479 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 292564005480 Walker A motif; other site 292564005481 ATP binding site [chemical binding]; other site 292564005482 Walker B motif; other site 292564005483 arginine finger; other site 292564005484 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 292564005485 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 292564005486 active site 292564005487 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 292564005488 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 292564005489 DXD motif; other site 292564005490 Stage II sporulation protein; Region: SpoIID; pfam08486 292564005491 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 292564005492 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 292564005493 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 292564005494 23S rRNA binding site [nucleotide binding]; other site 292564005495 L21 binding site [polypeptide binding]; other site 292564005496 L13 binding site [polypeptide binding]; other site 292564005497 TPR repeat; Region: TPR_11; pfam13414 292564005498 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292564005499 TPR motif; other site 292564005500 binding surface 292564005501 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 292564005502 ThiS interaction site; other site 292564005503 putative active site [active] 292564005504 tetramer interface [polypeptide binding]; other site 292564005505 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 292564005506 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 292564005507 NAD(P) binding site [chemical binding]; other site 292564005508 active site 292564005509 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 292564005510 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 292564005511 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 292564005512 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 292564005513 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 292564005514 GMP synthase; Reviewed; Region: guaA; PRK00074 292564005515 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 292564005516 AMP/PPi binding site [chemical binding]; other site 292564005517 candidate oxyanion hole; other site 292564005518 catalytic triad [active] 292564005519 potential glutamine specificity residues [chemical binding]; other site 292564005520 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 292564005521 ATP Binding subdomain [chemical binding]; other site 292564005522 Ligand Binding sites [chemical binding]; other site 292564005523 Dimerization subdomain; other site 292564005524 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 292564005525 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 292564005526 homodimer interface [polypeptide binding]; other site 292564005527 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292564005528 catalytic residue [active] 292564005529 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 292564005530 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 292564005531 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 292564005532 nucleotide binding region [chemical binding]; other site 292564005533 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 292564005534 ATP-binding site [chemical binding]; other site 292564005535 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 292564005536 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 292564005537 active site 292564005538 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 292564005539 NADH(P)-binding; Region: NAD_binding_10; pfam13460 292564005540 putative NAD(P) binding site [chemical binding]; other site 292564005541 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 292564005542 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 292564005543 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 292564005544 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 292564005545 carboxyltransferase (CT) interaction site; other site 292564005546 biotinylation site [posttranslational modification]; other site 292564005547 elongation factor P; Validated; Region: PRK00529 292564005548 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 292564005549 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 292564005550 RNA binding site [nucleotide binding]; other site 292564005551 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 292564005552 RNA binding site [nucleotide binding]; other site 292564005553 photosystem II protein PsbQ; Region: PS_II_psbQ_bact; TIGR03042 292564005554 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 292564005555 active site 292564005556 thiamine monophosphate kinase; Provisional; Region: PRK05731 292564005557 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 292564005558 dimerization interface [polypeptide binding]; other site 292564005559 ATP binding site [chemical binding]; other site 292564005560 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403 292564005561 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 292564005562 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 292564005563 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 292564005564 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 292564005565 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 292564005566 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 292564005567 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 292564005568 FAD binding domain; Region: FAD_binding_4; pfam01565 292564005569 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 292564005570 hypothetical protein; Validated; Region: PRK00153 292564005571 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 292564005572 RNA binding site [nucleotide binding]; other site 292564005573 GTPase RsgA; Reviewed; Region: PRK00098 292564005574 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 292564005575 GTPase/Zn-binding domain interface [polypeptide binding]; other site 292564005576 GTP/Mg2+ binding site [chemical binding]; other site 292564005577 G4 box; other site 292564005578 G5 box; other site 292564005579 G1 box; other site 292564005580 Switch I region; other site 292564005581 G2 box; other site 292564005582 G3 box; other site 292564005583 Switch II region; other site 292564005584 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 292564005585 CPxP motif; other site 292564005586 chaperone protein DnaJ; Provisional; Region: PRK14293 292564005587 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 292564005588 HSP70 interaction site [polypeptide binding]; other site 292564005589 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 292564005590 substrate binding site [polypeptide binding]; other site 292564005591 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 292564005592 Zn binding sites [ion binding]; other site 292564005593 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 292564005594 dimer interface [polypeptide binding]; other site 292564005595 GrpE; Region: GrpE; pfam01025 292564005596 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 292564005597 dimer interface [polypeptide binding]; other site 292564005598 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 292564005599 Type II/IV secretion system protein; Region: T2SE; pfam00437 292564005600 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 292564005601 Walker A motif; other site 292564005602 ATP binding site [chemical binding]; other site 292564005603 Walker B motif; other site 292564005604 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 292564005605 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 292564005606 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 292564005607 flavoprotein, HI0933 family; Region: TIGR00275 292564005608 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 292564005609 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 292564005610 FMN binding site [chemical binding]; other site 292564005611 active site 292564005612 catalytic residues [active] 292564005613 substrate binding site [chemical binding]; other site 292564005614 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 292564005615 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 292564005616 argininosuccinate lyase; Provisional; Region: PRK00855 292564005617 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 292564005618 active sites [active] 292564005619 tetramer interface [polypeptide binding]; other site 292564005620 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 292564005621 GAF domain; Region: GAF; cl17456 292564005622 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 292564005623 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 292564005624 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 292564005625 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 292564005626 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 292564005627 transcription antitermination protein NusB; Provisional; Region: nusB; PRK09634 292564005628 Uncharacterized conserved protein [Function unknown]; Region: COG2928 292564005629 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 292564005630 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 292564005631 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292564005632 TPR motif; other site 292564005633 binding surface 292564005634 TPR repeat; Region: TPR_11; pfam13414 292564005635 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292564005636 binding surface 292564005637 TPR motif; other site 292564005638 TPR repeat; Region: TPR_11; pfam13414 292564005639 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit [DNA replication, recombination, and repair]; Region: GyrA; COG0188 292564005640 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 292564005641 CAP-like domain; other site 292564005642 active site 292564005643 primary dimer interface [polypeptide binding]; other site 292564005644 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 292564005645 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 292564005646 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 292564005647 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 292564005648 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 292564005649 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 292564005650 AAA domain; Region: AAA_17; pfam13207 292564005651 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 292564005652 RibD C-terminal domain; Region: RibD_C; cl17279 292564005653 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 292564005654 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 292564005655 Coenzyme A binding pocket [chemical binding]; other site 292564005656 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 292564005657 MarR family; Region: MarR; pfam01047 292564005658 Protein of unknown function, DUF606; Region: DUF606; pfam04657 292564005659 Protein of unknown function, DUF606; Region: DUF606; pfam04657 292564005660 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 292564005661 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 292564005662 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 292564005663 active site 292564005664 metal binding site [ion binding]; metal-binding site 292564005665 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 292564005666 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 292564005667 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 292564005668 Coenzyme A binding pocket [chemical binding]; other site 292564005669 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 292564005670 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 292564005671 SnoaL-like domain; Region: SnoaL_3; pfam13474 292564005672 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 292564005673 Transposase; Region: HTH_Tnp_1; pfam01527 292564005674 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 292564005675 HTH-like domain; Region: HTH_21; pfam13276 292564005676 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 292564005677 Integrase core domain; Region: rve; pfam00665 292564005678 Integrase core domain; Region: rve_3; pfam13683 292564005679 Protein of unknown function DUF86; Region: DUF86; cl01031 292564005680 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 292564005681 active site 292564005682 NTP binding site [chemical binding]; other site 292564005683 metal binding triad [ion binding]; metal-binding site 292564005684 antibiotic binding site [chemical binding]; other site 292564005685 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 292564005686 Putative transposase; Region: Y2_Tnp; pfam04986 292564005687 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 292564005688 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 292564005689 active site 292564005690 DNA binding site [nucleotide binding] 292564005691 Int/Topo IB signature motif; other site 292564005692 integron integrase; Region: integrase_gron; TIGR02249 292564005693 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 292564005694 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 292564005695 active site 292564005696 DNA binding site [nucleotide binding] 292564005697 Int/Topo IB signature motif; other site 292564005698 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 292564005699 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 292564005700 putative active site [active] 292564005701 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 292564005702 Coenzyme A binding pocket [chemical binding]; other site 292564005703 Phytochelatin synthase; Region: Phytochelatin; pfam05023 292564005704 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 292564005705 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 292564005706 amidophosphoribosyltransferase; Provisional; Region: PRK07349 292564005707 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 292564005708 active site 292564005709 tetramer interface [polypeptide binding]; other site 292564005710 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 292564005711 active site 292564005712 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 292564005713 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 292564005714 dimerization interface [polypeptide binding]; other site 292564005715 ATP binding site [chemical binding]; other site 292564005716 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 292564005717 dimerization interface [polypeptide binding]; other site 292564005718 ATP binding site [chemical binding]; other site 292564005719 DNA polymerase III subunit beta; Validated; Region: PRK05643 292564005720 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 292564005721 putative DNA binding surface [nucleotide binding]; other site 292564005722 dimer interface [polypeptide binding]; other site 292564005723 beta-clamp/clamp loader binding surface; other site 292564005724 beta-clamp/translesion DNA polymerase binding surface; other site 292564005725 threonine synthase; Reviewed; Region: PRK06721 292564005726 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 292564005727 homodimer interface [polypeptide binding]; other site 292564005728 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292564005729 catalytic residue [active] 292564005730 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 292564005731 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 292564005732 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 292564005733 active site 292564005734 substrate binding site [chemical binding]; other site 292564005735 ATP binding site [chemical binding]; other site 292564005736 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 292564005737 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292564005738 Walker A/P-loop; other site 292564005739 ATP binding site [chemical binding]; other site 292564005740 Q-loop/lid; other site 292564005741 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 292564005742 ABC transporter signature motif; other site 292564005743 Walker B; other site 292564005744 D-loop; other site 292564005745 H-loop/switch region; other site 292564005746 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 292564005747 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 292564005748 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 292564005749 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 292564005750 motif II; other site 292564005751 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 292564005752 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 292564005753 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 292564005754 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 292564005755 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 292564005756 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 292564005757 catalytic residue [active] 292564005758 GXWXG protein; Region: GXWXG; pfam14231 292564005759 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 292564005760 short chain dehydrogenase; Provisional; Region: PRK06197 292564005761 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 292564005762 putative NAD(P) binding site [chemical binding]; other site 292564005763 active site 292564005764 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 292564005765 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 292564005766 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 292564005767 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 292564005768 Transcriptional regulator [Transcription]; Region: LytR; COG1316 292564005769 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; Region: 2-Hacid_dh_C; pfam02826 292564005770 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 292564005771 ATP-grasp domain; Region: ATP-grasp_4; cl17255 292564005772 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 292564005773 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 292564005774 Mg++ binding site [ion binding]; other site 292564005775 putative catalytic motif [active] 292564005776 putative substrate binding site [chemical binding]; other site 292564005777 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 292564005778 argininosuccinate synthase; Provisional; Region: PRK13820 292564005779 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 292564005780 ANP binding site [chemical binding]; other site 292564005781 Substrate Binding Site II [chemical binding]; other site 292564005782 Substrate Binding Site I [chemical binding]; other site 292564005783 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 292564005784 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 292564005785 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 292564005786 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 292564005787 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 292564005788 shikimate binding site; other site 292564005789 NAD(P) binding site [chemical binding]; other site 292564005790 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 292564005791 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 292564005792 nucleotide binding site [chemical binding]; other site 292564005793 NEF interaction site [polypeptide binding]; other site 292564005794 SBD interface [polypeptide binding]; other site 292564005795 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 292564005796 photosystem II protein PsbQ; Region: PS_II_psbQ_bact; TIGR03042 292564005797 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 292564005798 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 292564005799 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 292564005800 putative active site [active] 292564005801 putative substrate binding site [chemical binding]; other site 292564005802 putative cosubstrate binding site; other site 292564005803 catalytic site [active] 292564005804 O-Antigen ligase; Region: Wzy_C; pfam04932 292564005805 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 292564005806 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 292564005807 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 292564005808 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 292564005809 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 292564005810 active site 292564005811 NTP binding site [chemical binding]; other site 292564005812 metal binding triad [ion binding]; metal-binding site 292564005813 antibiotic binding site [chemical binding]; other site 292564005814 HEPN domain; Region: HEPN; cl00824 292564005815 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 292564005816 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 292564005817 synthetase active site [active] 292564005818 NTP binding site [chemical binding]; other site 292564005819 metal binding site [ion binding]; metal-binding site 292564005820 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 292564005821 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 292564005822 substrate binding site [chemical binding]; other site 292564005823 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 292564005824 substrate binding site [chemical binding]; other site 292564005825 ligand binding site [chemical binding]; other site 292564005826 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 292564005827 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 292564005828 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 292564005829 Mechanosensitive ion channel; Region: MS_channel; pfam00924 292564005830 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 292564005831 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 292564005832 ligand binding site [chemical binding]; other site 292564005833 flexible hinge region; other site 292564005834 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 292564005835 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 292564005836 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 292564005837 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 292564005838 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 292564005839 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 292564005840 DNA binding residues [nucleotide binding] 292564005841 polyphosphate kinase; Provisional; Region: PRK05443 292564005842 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 292564005843 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 292564005844 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 292564005845 putative domain interface [polypeptide binding]; other site 292564005846 putative active site [active] 292564005847 catalytic site [active] 292564005848 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 292564005849 putative domain interface [polypeptide binding]; other site 292564005850 putative active site [active] 292564005851 catalytic site [active] 292564005852 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 292564005853 Major Facilitator Superfamily; Region: MFS_1; pfam07690 292564005854 putative substrate translocation pore; other site 292564005855 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 292564005856 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 292564005857 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 292564005858 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 292564005859 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 292564005860 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 292564005861 active site 292564005862 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 292564005863 proximal heme binding site [chemical binding]; other site 292564005864 putative dimer interface [polypeptide binding]; other site 292564005865 putative Iron-sulfur protein interface [polypeptide binding]; other site 292564005866 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 292564005867 L-aspartate oxidase; Provisional; Region: PRK06175 292564005868 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 292564005869 PAS fold; Region: PAS; pfam00989 292564005870 PAS domain; Region: PAS; smart00091 292564005871 putative active site [active] 292564005872 heme pocket [chemical binding]; other site 292564005873 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 292564005874 metal binding site [ion binding]; metal-binding site 292564005875 active site 292564005876 I-site; other site 292564005877 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 292564005878 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 292564005879 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 292564005880 Acetokinase family; Region: Acetate_kinase; cl17229 292564005881 putative phosphoketolase; Provisional; Region: PRK05261 292564005882 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 292564005883 TPP-binding site; other site 292564005884 XFP C-terminal domain; Region: XFP_C; pfam09363 292564005885 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 292564005886 catalytic core [active] 292564005887 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 292564005888 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 292564005889 [4Fe-4S] binding site [ion binding]; other site 292564005890 molybdopterin cofactor binding site; other site 292564005891 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 292564005892 molybdopterin cofactor binding site; other site 292564005893 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 292564005894 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 292564005895 Walker A/P-loop; other site 292564005896 ATP binding site [chemical binding]; other site 292564005897 Q-loop/lid; other site 292564005898 ABC transporter signature motif; other site 292564005899 Walker B; other site 292564005900 D-loop; other site 292564005901 H-loop/switch region; other site 292564005902 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 292564005903 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 292564005904 Walker A/P-loop; other site 292564005905 ATP binding site [chemical binding]; other site 292564005906 Q-loop/lid; other site 292564005907 ABC transporter signature motif; other site 292564005908 Walker B; other site 292564005909 D-loop; other site 292564005910 H-loop/switch region; other site 292564005911 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 292564005912 NMT1-like family; Region: NMT1_2; pfam13379 292564005913 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 292564005914 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 292564005915 dimer interface [polypeptide binding]; other site 292564005916 conserved gate region; other site 292564005917 putative PBP binding loops; other site 292564005918 ABC-ATPase subunit interface; other site 292564005919 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 292564005920 NMT1-like family; Region: NMT1_2; pfam13379 292564005921 hypothetical protein; Provisional; Region: PRK07394 292564005922 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 292564005923 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 292564005924 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 292564005925 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 292564005926 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 292564005927 Ligand Binding Site [chemical binding]; other site 292564005928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 292564005929 dimer interface [polypeptide binding]; other site 292564005930 ABC-ATPase subunit interface; other site 292564005931 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 292564005932 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 292564005933 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 292564005934 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 292564005935 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 292564005936 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 292564005937 catalytic triad [active] 292564005938 hypothetical protein; Provisional; Region: PRK07394 292564005939 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 292564005940 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 292564005941 active site 292564005942 SAM binding site [chemical binding]; other site 292564005943 homodimer interface [polypeptide binding]; other site 292564005944 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 292564005945 trimer interface [polypeptide binding]; other site 292564005946 dimer interface [polypeptide binding]; other site 292564005947 putative active site [active] 292564005948 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 292564005949 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 292564005950 dimer interface [polypeptide binding]; other site 292564005951 putative functional site; other site 292564005952 putative MPT binding site; other site 292564005953 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 292564005954 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 292564005955 MoaE homodimer interface [polypeptide binding]; other site 292564005956 MoaD interaction [polypeptide binding]; other site 292564005957 active site residues [active] 292564005958 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 292564005959 MoaE interaction surface [polypeptide binding]; other site 292564005960 MoeB interaction surface [polypeptide binding]; other site 292564005961 thiocarboxylated glycine; other site 292564005962 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 292564005963 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 292564005964 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 292564005965 metal binding site [ion binding]; metal-binding site 292564005966 active site 292564005967 I-site; other site 292564005968 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 292564005969 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 292564005970 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 292564005971 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 292564005972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292564005973 homodimer interface [polypeptide binding]; other site 292564005974 catalytic residue [active] 292564005975 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 292564005976 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 292564005977 MOSC domain; Region: MOSC; pfam03473 292564005978 Restriction endonuclease; Region: Mrr_cat; pfam04471 292564005979 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 292564005980 nudix motif; other site 292564005981 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 292564005982 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 292564005983 metal binding site [ion binding]; metal-binding site 292564005984 active site 292564005985 I-site; other site 292564005986 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 292564005987 putative active site [active] 292564005988 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 292564005989 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 292564005990 putative active site [active] 292564005991 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 292564005992 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 292564005993 phosphorylation site [posttranslational modification] 292564005994 intermolecular recognition site; other site 292564005995 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 292564005996 DNA binding residues [nucleotide binding] 292564005997 dimerization interface [polypeptide binding]; other site 292564005998 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 292564005999 Fic family protein [Function unknown]; Region: COG3177 292564006000 Fic/DOC family; Region: Fic; pfam02661 292564006001 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 292564006002 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 292564006003 Fic/DOC family; Region: Fic; cl00960 292564006004 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 292564006005 AAA domain; Region: AAA_25; pfam13481 292564006006 Walker A motif; other site 292564006007 ATP binding site [chemical binding]; other site 292564006008 Walker B motif; other site 292564006009 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 292564006010 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 292564006011 active site 292564006012 catalytic residues [active] 292564006013 DNA binding site [nucleotide binding] 292564006014 Int/Topo IB signature motif; other site 292564006015 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 292564006016 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; cl01017 292564006017 Methyltransferase domain; Region: Methyltransf_31; pfam13847 292564006018 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292564006019 S-adenosylmethionine binding site [chemical binding]; other site 292564006020 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 292564006021 Uncharacterized conserved protein [Function unknown]; Region: COG0398 292564006022 mercuric reductase; Validated; Region: PRK06370 292564006023 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 292564006024 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 292564006025 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 292564006026 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 292564006027 Ligand binding site; other site 292564006028 Putative Catalytic site; other site 292564006029 DXD motif; other site 292564006030 Protein of unknown function, DUF547; Region: DUF547; pfam04784 292564006031 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 292564006032 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 292564006033 FeS/SAM binding site; other site 292564006034 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 292564006035 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 292564006036 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 292564006037 Predicted permease [General function prediction only]; Region: COG3329 292564006038 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 292564006039 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 292564006040 homodimer interface [polypeptide binding]; other site 292564006041 metal binding site [ion binding]; metal-binding site 292564006042 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 292564006043 homodimer interface [polypeptide binding]; other site 292564006044 active site 292564006045 putative chemical substrate binding site [chemical binding]; other site 292564006046 metal binding site [ion binding]; metal-binding site 292564006047 hypothetical protein; Provisional; Region: PRK09256 292564006048 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 292564006049 active site clefts [active] 292564006050 zinc binding site [ion binding]; other site 292564006051 dimer interface [polypeptide binding]; other site 292564006052 spermidine synthase; Provisional; Region: PRK00811 292564006053 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292564006054 S-adenosylmethionine binding site [chemical binding]; other site 292564006055 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 292564006056 agmatinase; Region: agmatinase; TIGR01230 292564006057 putative active site [active] 292564006058 Mn binding site [ion binding]; other site 292564006059 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 292564006060 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 292564006061 ligand binding site [chemical binding]; other site 292564006062 flexible hinge region; other site 292564006063 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 292564006064 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 292564006065 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 292564006066 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 292564006067 dimer interface [polypeptide binding]; other site 292564006068 anticodon binding site; other site 292564006069 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 292564006070 homodimer interface [polypeptide binding]; other site 292564006071 motif 1; other site 292564006072 active site 292564006073 motif 2; other site 292564006074 GAD domain; Region: GAD; pfam02938 292564006075 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 292564006076 active site 292564006077 motif 3; other site 292564006078 Autotransporter beta-domain; Region: Autotransporter; smart00869 292564006079 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 292564006080 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 292564006081 dimerization interface [polypeptide binding]; other site 292564006082 DPS ferroxidase diiron center [ion binding]; other site 292564006083 ion pore; other site 292564006084 CTP synthetase; Validated; Region: pyrG; PRK05380 292564006085 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 292564006086 Catalytic site [active] 292564006087 active site 292564006088 UTP binding site [chemical binding]; other site 292564006089 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 292564006090 active site 292564006091 putative oxyanion hole; other site 292564006092 catalytic triad [active] 292564006093 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 292564006094 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 292564006095 Ecotin; Region: Ecotin; pfam03974 292564006096 secondary substrate binding site; other site 292564006097 primary substrate binding site; other site 292564006098 inhibition loop; other site 292564006099 dimerization interface [polypeptide binding]; other site 292564006100 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 292564006101 Ligand Binding Site [chemical binding]; other site 292564006102 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 292564006103 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 292564006104 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 292564006105 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 292564006106 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 292564006107 homodimer interface [polypeptide binding]; other site 292564006108 substrate-cofactor binding pocket; other site 292564006109 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292564006110 catalytic residue [active] 292564006111 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 292564006112 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 292564006113 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 292564006114 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 292564006115 Walker A/P-loop; other site 292564006116 ATP binding site [chemical binding]; other site 292564006117 Q-loop/lid; other site 292564006118 ABC transporter signature motif; other site 292564006119 Walker B; other site 292564006120 D-loop; other site 292564006121 H-loop/switch region; other site 292564006122 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 292564006123 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 292564006124 Walker A/P-loop; other site 292564006125 ATP binding site [chemical binding]; other site 292564006126 Q-loop/lid; other site 292564006127 ABC transporter signature motif; other site 292564006128 Walker B; other site 292564006129 D-loop; other site 292564006130 H-loop/switch region; other site 292564006131 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 292564006132 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 292564006133 TM-ABC transporter signature motif; other site 292564006134 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 292564006135 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 292564006136 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 292564006137 TM-ABC transporter signature motif; other site 292564006138 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 292564006139 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 292564006140 putative ligand binding site [chemical binding]; other site 292564006141 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 292564006142 mce related protein; Region: MCE; pfam02470 292564006143 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 292564006144 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 292564006145 UreF; Region: UreF; pfam01730 292564006146 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 292564006147 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 292564006148 dimer interface [polypeptide binding]; other site 292564006149 catalytic residues [active] 292564006150 UreD urease accessory protein; Region: UreD; pfam01774 292564006151 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 292564006152 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 292564006153 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 292564006154 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 292564006155 Beta-lactamase; Region: Beta-lactamase; pfam00144 292564006156 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 292564006157 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 292564006158 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 292564006159 alpha-gamma subunit interface [polypeptide binding]; other site 292564006160 beta-gamma subunit interface [polypeptide binding]; other site 292564006161 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 292564006162 gamma-beta subunit interface [polypeptide binding]; other site 292564006163 alpha-beta subunit interface [polypeptide binding]; other site 292564006164 urease subunit alpha; Reviewed; Region: ureC; PRK13207 292564006165 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 292564006166 subunit interactions [polypeptide binding]; other site 292564006167 active site 292564006168 flap region; other site 292564006169 PilZ domain; Region: PilZ; pfam07238 292564006170 Uncharacterized conserved protein [Function unknown]; Region: COG2308 292564006171 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 292564006172 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 292564006173 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 292564006174 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 292564006175 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 292564006176 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 292564006177 homodimer interface [polypeptide binding]; other site 292564006178 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 292564006179 active site pocket [active] 292564006180 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 292564006181 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 292564006182 PAS domain; Region: PAS_9; pfam13426 292564006183 PAS fold; Region: PAS_3; pfam08447 292564006184 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 292564006185 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 292564006186 metal binding site [ion binding]; metal-binding site 292564006187 active site 292564006188 I-site; other site 292564006189 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 292564006190 Curli production assembly/transport component CsgG; Region: CsgG; pfam03783 292564006191 Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; cl09869 292564006192 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 292564006193 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 292564006194 GTP binding site; other site 292564006195 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 292564006196 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 292564006197 FeS/SAM binding site; other site 292564006198 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 292564006199 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 292564006200 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 292564006201 molybdopterin cofactor binding site; other site 292564006202 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 292564006203 molybdopterin cofactor binding site; other site 292564006204 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 292564006205 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 292564006206 active site 292564006207 metal binding site [ion binding]; metal-binding site 292564006208 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 292564006209 GSH binding site [chemical binding]; other site 292564006210 catalytic residues [active] 292564006211 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 292564006212 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 292564006213 Domain of unknown function (DUF1971); Region: DUF1971; pfam09313 292564006214 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 292564006215 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 292564006216 dimer interface [polypeptide binding]; other site 292564006217 active site 292564006218 heme binding site [chemical binding]; other site 292564006219 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 292564006220 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 292564006221 catalytic residue [active] 292564006222 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 292564006223 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 292564006224 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 292564006225 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 292564006226 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 292564006227 high affinity sulphate transporter 1; Region: sulP; TIGR00815 292564006228 Sulfate transporter family; Region: Sulfate_transp; pfam00916 292564006229 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 292564006230 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 292564006231 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 292564006232 dimerization interface [polypeptide binding]; other site 292564006233 ATP binding site [chemical binding]; other site 292564006234 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 292564006235 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 292564006236 active site residue [active] 292564006237 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 292564006238 Protein of unknown function, DUF399; Region: DUF399; pfam04187 292564006239 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 292564006240 protein binding site [polypeptide binding]; other site 292564006241 Pterin 4 alpha carbinolamine dehydratase; Region: Pterin_4a; pfam01329 292564006242 aromatic arch; other site 292564006243 DCoH dimer interaction site [polypeptide binding]; other site 292564006244 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 292564006245 DCoH tetramer interaction site [polypeptide binding]; other site 292564006246 substrate binding site [chemical binding]; other site 292564006247 CsbD-like; Region: CsbD; cl17424 292564006248 Small integral membrane protein [Function unknown]; Region: COG5487; cl17674 292564006249 MgtC family; Region: MgtC; pfam02308 292564006250 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 292564006251 Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069 292564006252 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 292564006253 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 292564006254 Pterin 4 alpha carbinolamine dehydratase; Region: Pterin_4a; pfam01329 292564006255 aromatic arch; other site 292564006256 DCoH dimer interaction site [polypeptide binding]; other site 292564006257 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 292564006258 DCoH tetramer interaction site [polypeptide binding]; other site 292564006259 substrate binding site [chemical binding]; other site 292564006260 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 292564006261 RibD C-terminal domain; Region: RibD_C; cl17279 292564006262 C factor cell-cell signaling protein; Provisional; Region: PRK09009 292564006263 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 292564006264 NADP binding site [chemical binding]; other site 292564006265 homodimer interface [polypeptide binding]; other site 292564006266 active site 292564006267 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 292564006268 Cation efflux family; Region: Cation_efflux; cl00316 292564006269 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292564006270 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 292564006271 Walker A/P-loop; other site 292564006272 ATP binding site [chemical binding]; other site 292564006273 Q-loop/lid; other site 292564006274 ABC transporter signature motif; other site 292564006275 Walker B; other site 292564006276 D-loop; other site 292564006277 H-loop/switch region; other site 292564006278 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 292564006279 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 292564006280 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 292564006281 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 292564006282 nucleoside/Zn binding site; other site 292564006283 dimer interface [polypeptide binding]; other site 292564006284 catalytic motif [active] 292564006285 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 292564006286 MPT binding site; other site 292564006287 trimer interface [polypeptide binding]; other site 292564006288 O-methyltransferase; Region: Methyltransf_2; pfam00891 292564006289 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 292564006290 dimer interface [polypeptide binding]; other site 292564006291 FMN binding site [chemical binding]; other site 292564006292 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 292564006293 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 292564006294 active site 292564006295 metal binding site [ion binding]; metal-binding site 292564006296 putative lipid kinase; Reviewed; Region: PRK00861 292564006297 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 292564006298 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 292564006299 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 292564006300 Peptidase M35 family; Region: M35_like; cl03449 292564006301 active site 292564006302 Zn binding site [ion binding]; other site 292564006303 Transposase; Region: HTH_Tnp_1; pfam01527 292564006304 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 292564006305 putative transposase OrfB; Reviewed; Region: PHA02517 292564006306 HTH-like domain; Region: HTH_21; pfam13276 292564006307 Integrase core domain; Region: rve; pfam00665 292564006308 Integrase core domain; Region: rve_3; pfam13683 292564006309 Transposase; Region: HTH_Tnp_1; cl17663 292564006310 Integrase core domain; Region: rve; pfam00665 292564006311 DDE domain; Region: DDE_Tnp_IS240; pfam13610 292564006312 Integrase core domain; Region: rve_3; pfam13683 292564006313 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 292564006314 GAF domain; Region: GAF; pfam01590 292564006315 PAS fold; Region: PAS_4; pfam08448 292564006316 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292564006317 putative active site [active] 292564006318 heme pocket [chemical binding]; other site 292564006319 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292564006320 PAS fold; Region: PAS_3; pfam08447 292564006321 putative active site [active] 292564006322 heme pocket [chemical binding]; other site 292564006323 PAS fold; Region: PAS; pfam00989 292564006324 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292564006325 putative active site [active] 292564006326 heme pocket [chemical binding]; other site 292564006327 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 292564006328 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 292564006329 metal binding site [ion binding]; metal-binding site 292564006330 active site 292564006331 I-site; other site 292564006332 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 292564006333 Transposase; Region: HTH_Tnp_1; pfam01527 292564006334 putative transposase OrfB; Reviewed; Region: PHA02517 292564006335 HTH-like domain; Region: HTH_21; pfam13276 292564006336 Integrase core domain; Region: rve; pfam00665 292564006337 Integrase core domain; Region: rve_3; pfam13683 292564006338 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 292564006339 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 292564006340 Domain of unknown function (DUF4269); Region: DUF4269; pfam14091 292564006341 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 292564006342 putative dimer interface [polypeptide binding]; other site 292564006343 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 292564006344 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 292564006345 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 292564006346 NAD(P) binding site [chemical binding]; other site 292564006347 active site 292564006348 bile acid transporter; Region: bass; TIGR00841 292564006349 Sodium Bile acid symporter family; Region: SBF; cl17470 292564006350 Protein of unknown function; Region: DUF3721; pfam12518 292564006351 GLTT repeat (6 copies); Region: GLTT; pfam01744 292564006352 Protein of unknown function; Region: DUF3721; pfam12518 292564006353 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 292564006354 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 292564006355 Coenzyme A binding pocket [chemical binding]; other site 292564006356 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 292564006357 dimerization interface [polypeptide binding]; other site 292564006358 putative DNA binding site [nucleotide binding]; other site 292564006359 putative Zn2+ binding site [ion binding]; other site 292564006360 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 292564006361 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 292564006362 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 292564006363 Moco binding site; other site 292564006364 metal coordination site [ion binding]; other site 292564006365 Electron transfer DM13; Region: DM13; pfam10517 292564006366 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 292564006367 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 292564006368 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 292564006369 DNA binding residues [nucleotide binding] 292564006370 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 292564006371 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 292564006372 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 292564006373 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 292564006374 ABC-ATPase subunit interface; other site 292564006375 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 292564006376 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 292564006377 Mechanosensitive ion channel; Region: MS_channel; pfam00924 292564006378 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 292564006379 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 292564006380 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 292564006381 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 292564006382 putative acyl-acceptor binding pocket; other site 292564006383 GDYXXLXY protein; Region: GDYXXLXY; cl02066 292564006384 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 292564006385 Sulfatase; Region: Sulfatase; pfam00884 292564006386 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 292564006387 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 292564006388 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 292564006389 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 292564006390 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 292564006391 active site 292564006392 HIGH motif; other site 292564006393 nucleotide binding site [chemical binding]; other site 292564006394 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 292564006395 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 292564006396 active site 292564006397 KMSKS motif; other site 292564006398 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 292564006399 tRNA binding surface [nucleotide binding]; other site 292564006400 anticodon binding site; other site 292564006401 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 292564006402 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 292564006403 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 292564006404 Jacalin-like lectin domain; Region: Jacalin_like; cl03205 292564006405 putative sugar binding site [chemical binding]; other site 292564006406 Uncharacterized conserved protein [Function unknown]; Region: COG0398 292564006407 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 292564006408 Methyltransferase domain; Region: Methyltransf_23; pfam13489 292564006409 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 292564006410 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 292564006411 HlyD family secretion protein; Region: HlyD_3; pfam13437 292564006412 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 292564006413 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 292564006414 ligand binding site [chemical binding]; other site 292564006415 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 292564006416 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 292564006417 putative active site [active] 292564006418 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 292564006419 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292564006420 Walker A/P-loop; other site 292564006421 ATP binding site [chemical binding]; other site 292564006422 Q-loop/lid; other site 292564006423 ABC transporter signature motif; other site 292564006424 Walker B; other site 292564006425 D-loop; other site 292564006426 H-loop/switch region; other site 292564006427 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 292564006428 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 292564006429 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 292564006430 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 292564006431 DXD motif; other site 292564006432 PilZ domain; Region: PilZ; pfam07238 292564006433 multidrug resistance protein MdtN; Provisional; Region: PRK10476 292564006434 HlyD family secretion protein; Region: HlyD_3; pfam13437 292564006435 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 292564006436 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 292564006437 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 292564006438 nucleotide binding pocket [chemical binding]; other site 292564006439 K-X-D-G motif; other site 292564006440 catalytic site [active] 292564006441 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 292564006442 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 292564006443 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 292564006444 Dimer interface [polypeptide binding]; other site 292564006445 BRCT sequence motif; other site 292564006446 SprT homologues; Region: SprT; cl01182 292564006447 SprT-like family; Region: SprT-like; pfam10263 292564006448 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 292564006449 Protein of unknown function (DUF98); Region: DUF98; pfam01947 292564006450 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 292564006451 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 292564006452 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 292564006453 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 292564006454 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 292564006455 Isochorismatase family; Region: Isochorismatase; pfam00857 292564006456 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 292564006457 catalytic triad [active] 292564006458 conserved cis-peptide bond; other site 292564006459 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 292564006460 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 292564006461 replicative DNA helicase; Region: DnaB; TIGR00665 292564006462 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 292564006463 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 292564006464 Walker A motif; other site 292564006465 ATP binding site [chemical binding]; other site 292564006466 Walker B motif; other site 292564006467 DNA binding loops [nucleotide binding] 292564006468 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 292564006469 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 292564006470 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 292564006471 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 292564006472 Fatty acid desaturase; Region: FA_desaturase; pfam00487 292564006473 Di-iron ligands [ion binding]; other site 292564006474 Fatty acid desaturase; Region: FA_desaturase; pfam00487 292564006475 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 292564006476 Di-iron ligands [ion binding]; other site 292564006477 Aluminium resistance protein; Region: Alum_res; pfam06838 292564006478 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 292564006479 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 292564006480 lipoyl attachment site [posttranslational modification]; other site 292564006481 glycine dehydrogenase; Provisional; Region: PRK05367 292564006482 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 292564006483 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 292564006484 catalytic residue [active] 292564006485 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 292564006486 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 292564006487 catalytic residue [active] 292564006488 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 292564006489 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 292564006490 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 292564006491 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 292564006492 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 292564006493 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 292564006494 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 292564006495 PilZ domain; Region: PilZ; cl01260 292564006496 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 292564006497 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 292564006498 putative dimer interface [polypeptide binding]; other site 292564006499 MEKHLA domain; Region: MEKHLA; pfam08670 292564006500 Uncharacterized conserved protein [Function unknown]; Region: COG4279 292564006501 Fatty acid desaturase; Region: FA_desaturase; pfam00487 292564006502 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 292564006503 putative di-iron ligands [ion binding]; other site 292564006504 SNF2 Helicase protein; Region: DUF3670; pfam12419 292564006505 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 292564006506 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 292564006507 ATP binding site [chemical binding]; other site 292564006508 putative Mg++ binding site [ion binding]; other site 292564006509 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 292564006510 nucleotide binding region [chemical binding]; other site 292564006511 ATP-binding site [chemical binding]; other site 292564006512 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 292564006513 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 292564006514 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 292564006515 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 292564006516 alanine--tRNA ligase; Region: alaS; TIGR00344 292564006517 motif 1; other site 292564006518 active site 292564006519 motif 2; other site 292564006520 motif 3; other site 292564006521 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 292564006522 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 292564006523 CHAT domain; Region: CHAT; cl17868 292564006524 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 292564006525 CHASE2 domain; Region: CHASE2; pfam05226 292564006526 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 292564006527 cyclase homology domain; Region: CHD; cd07302 292564006528 nucleotidyl binding site; other site 292564006529 metal binding site [ion binding]; metal-binding site 292564006530 dimer interface [polypeptide binding]; other site 292564006531 Mechanosensitive ion channel; Region: MS_channel; pfam00924 292564006532 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 292564006533 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 292564006534 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 292564006535 ligand binding site [chemical binding]; other site 292564006536 flexible hinge region; other site 292564006537 Protein of unknown function (DUF541); Region: SIMPL; cl01077 292564006538 FecR protein; Region: FecR; pfam04773 292564006539 FecR protein; Region: FecR; pfam04773 292564006540 SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133 292564006541 CHASE2 domain; Region: CHASE2; pfam05226 292564006542 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 292564006543 cyclase homology domain; Region: CHD; cd07302 292564006544 nucleotidyl binding site; other site 292564006545 metal binding site [ion binding]; metal-binding site 292564006546 dimer interface [polypeptide binding]; other site 292564006547 arginine decarboxylase; Provisional; Region: PRK05354 292564006548 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 292564006549 active site 292564006550 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 292564006551 catalytic residues [active] 292564006552 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 292564006553 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 292564006554 active site 292564006555 multimer interface [polypeptide binding]; other site 292564006556 FecR protein; Region: FecR; pfam04773 292564006557 CHASE2 domain; Region: CHASE2; pfam05226 292564006558 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 292564006559 cyclase homology domain; Region: CHD; cd07302 292564006560 nucleotidyl binding site; other site 292564006561 metal binding site [ion binding]; metal-binding site 292564006562 dimer interface [polypeptide binding]; other site 292564006563 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 292564006564 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 292564006565 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 292564006566 GatB domain; Region: GatB_Yqey; smart00845 292564006567 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 292564006568 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 292564006569 CoA-binding site [chemical binding]; other site 292564006570 ATP-binding [chemical binding]; other site 292564006571 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 292564006572 heterotetramer interface [polypeptide binding]; other site 292564006573 active site pocket [active] 292564006574 cleavage site 292564006575 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 292564006576 ABC1 family; Region: ABC1; cl17513 292564006577 enolase; Provisional; Region: eno; PRK00077 292564006578 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 292564006579 dimer interface [polypeptide binding]; other site 292564006580 metal binding site [ion binding]; metal-binding site 292564006581 substrate binding pocket [chemical binding]; other site 292564006582 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 292564006583 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 292564006584 dimer interface [polypeptide binding]; other site 292564006585 active site 292564006586 metal binding site [ion binding]; metal-binding site 292564006587 glutathione binding site [chemical binding]; other site 292564006588 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 292564006589 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 292564006590 Walker A motif; other site 292564006591 ATP binding site [chemical binding]; other site 292564006592 Walker B motif; other site 292564006593 arginine finger; other site 292564006594 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 292564006595 Walker A motif; other site 292564006596 ATP binding site [chemical binding]; other site 292564006597 Walker B motif; other site 292564006598 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 292564006599 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 292564006600 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 292564006601 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 292564006602 putative homodimer interface [polypeptide binding]; other site 292564006603 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 292564006604 heterodimer interface [polypeptide binding]; other site 292564006605 homodimer interface [polypeptide binding]; other site 292564006606 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 292564006607 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 292564006608 23S rRNA interface [nucleotide binding]; other site 292564006609 L7/L12 interface [polypeptide binding]; other site 292564006610 putative thiostrepton binding site; other site 292564006611 L25 interface [polypeptide binding]; other site 292564006612 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 292564006613 mRNA/rRNA interface [nucleotide binding]; other site 292564006614 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 292564006615 active site 292564006616 catalytic triad [active] 292564006617 oxyanion hole [active] 292564006618 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 292564006619 23S rRNA interface [nucleotide binding]; other site 292564006620 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 292564006621 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 292564006622 core dimer interface [polypeptide binding]; other site 292564006623 peripheral dimer interface [polypeptide binding]; other site 292564006624 L10 interface [polypeptide binding]; other site 292564006625 L11 interface [polypeptide binding]; other site 292564006626 putative EF-Tu interaction site [polypeptide binding]; other site 292564006627 putative EF-G interaction site [polypeptide binding]; other site 292564006628 Protein of unknown function (DUF3747); Region: DUF3747; pfam12565 292564006629 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 292564006630 RNA/DNA hybrid binding site [nucleotide binding]; other site 292564006631 active site 292564006632 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 292564006633 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 292564006634 quinone interaction residues [chemical binding]; other site 292564006635 active site 292564006636 catalytic residues [active] 292564006637 FMN binding site [chemical binding]; other site 292564006638 substrate binding site [chemical binding]; other site 292564006639 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 292564006640 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 292564006641 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 292564006642 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292564006643 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 292564006644 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292564006645 binding surface 292564006646 TPR repeat; Region: TPR_11; pfam13414 292564006647 TPR motif; other site 292564006648 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 292564006649 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 292564006650 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 292564006651 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 292564006652 MoxR-like ATPases [General function prediction only]; Region: COG0714 292564006653 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 292564006654 Walker A motif; other site 292564006655 ATP binding site [chemical binding]; other site 292564006656 Walker B motif; other site 292564006657 arginine finger; other site 292564006658 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 292564006659 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 292564006660 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292564006661 homodimer interface [polypeptide binding]; other site 292564006662 catalytic residue [active] 292564006663 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 292564006664 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 292564006665 active site 292564006666 homodimer interface [polypeptide binding]; other site 292564006667 osmolarity response regulator; Provisional; Region: ompR; PRK09468 292564006668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292564006669 active site 292564006670 phosphorylation site [posttranslational modification] 292564006671 intermolecular recognition site; other site 292564006672 dimerization interface [polypeptide binding]; other site 292564006673 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 292564006674 DNA binding site [nucleotide binding] 292564006675 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 292564006676 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 292564006677 dimerization interface [polypeptide binding]; other site 292564006678 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292564006679 dimer interface [polypeptide binding]; other site 292564006680 phosphorylation site [posttranslational modification] 292564006681 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292564006682 ATP binding site [chemical binding]; other site 292564006683 Mg2+ binding site [ion binding]; other site 292564006684 G-X-G motif; other site 292564006685 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 292564006686 Phosphoglycerate kinase; Region: PGK; pfam00162 292564006687 substrate binding site [chemical binding]; other site 292564006688 hinge regions; other site 292564006689 ADP binding site [chemical binding]; other site 292564006690 catalytic site [active] 292564006691 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 292564006692 Ligand Binding Site [chemical binding]; other site 292564006693 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 292564006694 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 292564006695 GTP/Mg2+ binding site [chemical binding]; other site 292564006696 G4 box; other site 292564006697 G5 box; other site 292564006698 G1 box; other site 292564006699 Switch I region; other site 292564006700 G2 box; other site 292564006701 G3 box; other site 292564006702 Switch II region; other site 292564006703 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 292564006704 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 292564006705 RNA binding surface [nucleotide binding]; other site 292564006706 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 292564006707 active site 292564006708 Outer membrane efflux protein; Region: OEP; pfam02321 292564006709 NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794 292564006710 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 292564006711 HlyD family secretion protein; Region: HlyD_3; pfam13437 292564006712 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 292564006713 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 292564006714 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 292564006715 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 292564006716 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 292564006717 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 292564006718 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 292564006719 Subunit I/III interface [polypeptide binding]; other site 292564006720 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 292564006721 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 292564006722 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 292564006723 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 292564006724 Predicted membrane protein [Function unknown]; Region: COG4244 292564006725 Predicted membrane protein [Function unknown]; Region: COG4244 292564006726 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 292564006727 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 292564006728 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 292564006729 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 292564006730 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 292564006731 NAD(P) binding site [chemical binding]; other site 292564006732 active site 292564006733 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 292564006734 EamA-like transporter family; Region: EamA; pfam00892 292564006735 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 292564006736 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 292564006737 active site 292564006738 metal binding site [ion binding]; metal-binding site 292564006739 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 292564006740 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 292564006741 active site 292564006742 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 292564006743 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 292564006744 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 292564006745 active site 292564006746 catalytic site [active] 292564006747 DoxX; Region: DoxX; pfam07681 292564006748 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 292564006749 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 292564006750 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 292564006751 Walker A/P-loop; other site 292564006752 ATP binding site [chemical binding]; other site 292564006753 Q-loop/lid; other site 292564006754 ABC transporter signature motif; other site 292564006755 Walker B; other site 292564006756 D-loop; other site 292564006757 H-loop/switch region; other site 292564006758 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 292564006759 Walker A/P-loop; other site 292564006760 ATP binding site [chemical binding]; other site 292564006761 Q-loop/lid; other site 292564006762 ABC transporter signature motif; other site 292564006763 Walker B; other site 292564006764 D-loop; other site 292564006765 H-loop/switch region; other site 292564006766 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 292564006767 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 292564006768 Zn2+ binding site [ion binding]; other site 292564006769 Mg2+ binding site [ion binding]; other site 292564006770 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 292564006771 synthetase active site [active] 292564006772 NTP binding site [chemical binding]; other site 292564006773 metal binding site [ion binding]; metal-binding site 292564006774 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 292564006775 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 292564006776 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 292564006777 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 292564006778 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 292564006779 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 292564006780 putative ADP-binding pocket [chemical binding]; other site 292564006781 hypothetical protein; Validated; Region: PRK00029 292564006782 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 292564006783 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 292564006784 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 292564006785 Coenzyme A binding pocket [chemical binding]; other site 292564006786 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 292564006787 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 292564006788 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 292564006789 trmE is a tRNA modification GTPase; Region: trmE; cd04164 292564006790 G1 box; other site 292564006791 GTP/Mg2+ binding site [chemical binding]; other site 292564006792 Switch I region; other site 292564006793 G2 box; other site 292564006794 Switch II region; other site 292564006795 G3 box; other site 292564006796 G4 box; other site 292564006797 G5 box; other site 292564006798 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 292564006799 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 292564006800 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 292564006801 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 292564006802 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 292564006803 dimerization interface [polypeptide binding]; other site 292564006804 active site 292564006805 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 292564006806 substrate binding pocket [chemical binding]; other site 292564006807 extracellular substrate-binding orphan protein, GRRM family; Region: orph_peri_GRRM; TIGR04262 292564006808 membrane-bound complex binding site; other site 292564006809 hinge residues; other site 292564006810 radical SAM/SPASM domain protein, GRRM system; Region: rSAM_GlyRichRpt; TIGR04261 292564006811 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 292564006812 FeS/SAM binding site; other site 292564006813 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 292564006814 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 292564006815 active site 292564006816 arginine-tRNA ligase; Region: PLN02286 292564006817 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 292564006818 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 292564006819 active site 292564006820 HIGH motif; other site 292564006821 KMSK motif region; other site 292564006822 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 292564006823 tRNA binding surface [nucleotide binding]; other site 292564006824 anticodon binding site; other site 292564006825 Uncharacterized conserved protein [Function unknown]; Region: COG3349 292564006826 Uncharacterized conserved protein [Function unknown]; Region: COG3349 292564006827 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 292564006828 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 292564006829 substrate binding pocket [chemical binding]; other site 292564006830 chain length determination region; other site 292564006831 substrate-Mg2+ binding site; other site 292564006832 catalytic residues [active] 292564006833 aspartate-rich region 1; other site 292564006834 active site lid residues [active] 292564006835 aspartate-rich region 2; other site 292564006836 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 292564006837 Uncharacterized conserved protein [Function unknown]; Region: COG3268 292564006838 NAD(P) binding site [chemical binding]; other site 292564006839 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 292564006840 cyclase homology domain; Region: CHD; cd07302 292564006841 nucleotidyl binding site; other site 292564006842 metal binding site [ion binding]; metal-binding site 292564006843 dimer interface [polypeptide binding]; other site 292564006844 AAA ATPase domain; Region: AAA_16; pfam13191 292564006845 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 292564006846 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 292564006847 ligand binding site [chemical binding]; other site 292564006848 flexible hinge region; other site 292564006849 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 292564006850 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 292564006851 active site 292564006852 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 292564006853 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 292564006854 Coenzyme A binding pocket [chemical binding]; other site 292564006855 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 292564006856 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 292564006857 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292564006858 homodimer interface [polypeptide binding]; other site 292564006859 catalytic residue [active] 292564006860 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 292564006861 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 292564006862 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 292564006863 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 292564006864 glutamine binding [chemical binding]; other site 292564006865 catalytic triad [active] 292564006866 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 292564006867 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 292564006868 Protein of unknown function (DUF3285); Region: DUF3285; pfam11688 292564006869 peptide chain release factor 2; Validated; Region: prfB; PRK00578 292564006870 This domain is found in peptide chain release factors; Region: PCRF; smart00937 292564006871 RF-1 domain; Region: RF-1; pfam00472 292564006872 Fusaric acid resistance protein family; Region: FUSC; pfam04632 292564006873 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 292564006874 GSH binding site [chemical binding]; other site 292564006875 catalytic residues [active] 292564006876 glutathione synthetase; Provisional; Region: PRK05246 292564006877 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 292564006878 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 292564006879 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 292564006880 chorismate binding enzyme; Region: Chorismate_bind; cl10555 292564006881 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419 292564006882 UbiA prenyltransferase family; Region: UbiA; pfam01040 292564006883 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 292564006884 metal binding site [ion binding]; metal-binding site 292564006885 substrate binding pocket [chemical binding]; other site 292564006886 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 292564006887 active site 292564006888 CoA binding site [chemical binding]; other site 292564006889 AMP binding site [chemical binding]; other site 292564006890 TM2 domain; Region: TM2; pfam05154 292564006891 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 292564006892 active site 292564006893 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 292564006894 Fatty acid desaturase; Region: FA_desaturase; pfam00487 292564006895 Di-iron ligands [ion binding]; other site 292564006896 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 292564006897 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 292564006898 NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415 292564006899 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 292564006900 MraW methylase family; Region: Methyltransf_5; cl17771 292564006901 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 292564006902 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 292564006903 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 292564006904 catalytic residue [active] 292564006905 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 292564006906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292564006907 active site 292564006908 phosphorylation site [posttranslational modification] 292564006909 intermolecular recognition site; other site 292564006910 dimerization interface [polypeptide binding]; other site 292564006911 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 292564006912 DNA binding residues [nucleotide binding] 292564006913 dimerization interface [polypeptide binding]; other site 292564006914 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 292564006915 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 292564006916 active site 292564006917 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 292564006918 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 292564006919 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 292564006920 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 292564006921 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 292564006922 active site 292564006923 AIR carboxylase; Region: AIRC; pfam00731 292564006924 Domain of unknown function DUF20; Region: UPF0118; pfam01594 292564006925 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 292564006926 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 292564006927 ligand-binding site [chemical binding]; other site 292564006928 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 292564006929 putative rRNA binding site [nucleotide binding]; other site 292564006930 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 292564006931 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 292564006932 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 292564006933 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292564006934 catalytic residue [active] 292564006935 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 292564006936 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 292564006937 active site 292564006938 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 292564006939 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 292564006940 active site residue [active] 292564006941 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 292564006942 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 292564006943 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 292564006944 citrate synthase; Provisional; Region: PRK14036 292564006945 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 292564006946 oxalacetate binding site [chemical binding]; other site 292564006947 citrylCoA binding site [chemical binding]; other site 292564006948 coenzyme A binding site [chemical binding]; other site 292564006949 catalytic triad [active] 292564006950 NADH dehydrogenase; Region: NADHdh; cl00469 292564006951 NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403 292564006952 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 292564006953 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 292564006954 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 292564006955 NADH dehydrogenase subunit J; Provisional; Region: PRK06439 292564006956 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 292564006957 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 292564006958 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 292564006959 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 292564006960 putative active site [active] 292564006961 putative metal binding residues [ion binding]; other site 292564006962 signature motif; other site 292564006963 putative dimer interface [polypeptide binding]; other site 292564006964 putative phosphate binding site [ion binding]; other site 292564006965 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 292564006966 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 292564006967 dimerization interface [polypeptide binding]; other site 292564006968 DNA binding residues [nucleotide binding] 292564006969 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 292564006970 FAD binding site [chemical binding]; other site 292564006971 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 292564006972 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 292564006973 active site 292564006974 Substrate binding site; other site 292564006975 Mg++ binding site; other site 292564006976 Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356 292564006977 ScpA/B protein; Region: ScpA_ScpB; cl00598 292564006978 Protein of unknown function (DUF2730); Region: DUF2730; pfam10805 292564006979 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546 292564006980 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 292564006981 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 292564006982 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 292564006983 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 292564006984 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 292564006985 NnrU protein; Region: NnrU; cl17713 292564006986 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 292564006987 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 292564006988 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 292564006989 putative dimerization interface [polypeptide binding]; other site 292564006990 Protein of unknown function (DUF3172); Region: DUF3172; pfam11371 292564006991 Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664 292564006992 phytoene desaturase; Region: phytoene_desat; TIGR02731 292564006993 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 292564006994 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 292564006995 active site lid residues [active] 292564006996 substrate binding pocket [chemical binding]; other site 292564006997 catalytic residues [active] 292564006998 substrate-Mg2+ binding site; other site 292564006999 aspartate-rich region 1; other site 292564007000 aspartate-rich region 2; other site 292564007001 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 292564007002 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 292564007003 dimerization interface [polypeptide binding]; other site 292564007004 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 292564007005 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 292564007006 hydrolase, alpha/beta fold family protein; Region: PLN02824 292564007007 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 292564007008 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 292564007009 Walker A/P-loop; other site 292564007010 ATP binding site [chemical binding]; other site 292564007011 Q-loop/lid; other site 292564007012 ABC transporter signature motif; other site 292564007013 Walker B; other site 292564007014 D-loop; other site 292564007015 H-loop/switch region; other site 292564007016 DevC protein; Region: devC; TIGR01185 292564007017 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 292564007018 FtsX-like permease family; Region: FtsX; pfam02687 292564007019 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 292564007020 HlyD family secretion protein; Region: HlyD_3; pfam13437 292564007021 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 292564007022 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 292564007023 iron-sulfur cluster [ion binding]; other site 292564007024 [2Fe-2S] cluster binding site [ion binding]; other site 292564007025 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 292564007026 hydrophobic ligand binding site; other site 292564007027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 292564007028 Major Facilitator Superfamily; Region: MFS_1; pfam07690 292564007029 putative substrate translocation pore; other site 292564007030 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 292564007031 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 292564007032 [2Fe-2S] cluster binding site [ion binding]; other site 292564007033 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 292564007034 hydrophobic ligand binding site; other site 292564007035 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 292564007036 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 292564007037 iron-sulfur cluster [ion binding]; other site 292564007038 [2Fe-2S] cluster binding site [ion binding]; other site 292564007039 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 292564007040 hydrophobic ligand binding site; other site 292564007041 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 292564007042 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 292564007043 ligand binding site [chemical binding]; other site 292564007044 flexible hinge region; other site 292564007045 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 292564007046 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 292564007047 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 292564007048 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 292564007049 metal binding triad [ion binding]; metal-binding site 292564007050 Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718 292564007051 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 292564007052 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 292564007053 putative active site [active] 292564007054 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 292564007055 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 292564007056 putative acyl-acceptor binding pocket; other site 292564007057 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 292564007058 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 292564007059 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 292564007060 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 292564007061 dimer interface [polypeptide binding]; other site 292564007062 active site 292564007063 CoA binding pocket [chemical binding]; other site 292564007064 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 292564007065 Ycf27; Reviewed; Region: orf27; CHL00148 292564007066 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292564007067 active site 292564007068 phosphorylation site [posttranslational modification] 292564007069 intermolecular recognition site; other site 292564007070 dimerization interface [polypeptide binding]; other site 292564007071 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 292564007072 DNA binding site [nucleotide binding] 292564007073 DNA repair protein RadA; Provisional; Region: PRK11823 292564007074 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 292564007075 Walker A motif; other site 292564007076 ATP binding site [chemical binding]; other site 292564007077 Walker B motif; other site 292564007078 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 292564007079 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292564007080 binding surface 292564007081 TPR motif; other site 292564007082 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 292564007083 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 292564007084 metal-binding site [ion binding] 292564007085 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 292564007086 thymidylate kinase; Validated; Region: tmk; PRK00698 292564007087 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 292564007088 TMP-binding site; other site 292564007089 ATP-binding site [chemical binding]; other site 292564007090 DNA polymerase III subunit delta'; Validated; Region: PRK07399 292564007091 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 292564007092 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292564007093 active site 292564007094 phosphorylation site [posttranslational modification] 292564007095 intermolecular recognition site; other site 292564007096 dimerization interface [polypeptide binding]; other site 292564007097 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 292564007098 DNA binding site [nucleotide binding] 292564007099 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 292564007100 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 292564007101 Walker A/P-loop; other site 292564007102 ATP binding site [chemical binding]; other site 292564007103 Q-loop/lid; other site 292564007104 ABC transporter signature motif; other site 292564007105 Walker B; other site 292564007106 D-loop; other site 292564007107 H-loop/switch region; other site 292564007108 hypothetical protein; Provisional; Region: PRK13683 292564007109 D2 subunit of photosystem II (PS II); Region: Photosystem-II_D2; cd09288 292564007110 D1 interface; other site 292564007111 chlorophyll binding site; other site 292564007112 pheophytin binding site; other site 292564007113 beta carotene binding site; other site 292564007114 cytochrome b559 beta interface; other site 292564007115 quinone binding site; other site 292564007116 cytochrome b559 alpha interface; other site 292564007117 protein J interface; other site 292564007118 protein H interface; other site 292564007119 protein X interface; other site 292564007120 core light harvesting protein interface; other site 292564007121 protein L interface; other site 292564007122 CP43 interface; other site 292564007123 protein T interface; other site 292564007124 Fe binding site [ion binding]; other site 292564007125 protein M interface; other site 292564007126 Mn-stabilizing polypeptide interface; other site 292564007127 bromide binding site; other site 292564007128 cytochrome c-550 interface; other site 292564007129 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 292564007130 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 292564007131 Methyltransferase domain; Region: Methyltransf_23; pfam13489 292564007132 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292564007133 S-adenosylmethionine binding site [chemical binding]; other site 292564007134 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 292564007135 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 292564007136 Ligand binding site; other site 292564007137 Putative Catalytic site; other site 292564007138 DXD motif; other site 292564007139 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292564007140 binding surface 292564007141 TPR motif; other site 292564007142 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 292564007143 S-layer homology domain; Region: SLH; pfam00395 292564007144 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 292564007145 S-layer homology domain; Region: SLH; pfam00395 292564007146 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 292564007147 S-layer homology domain; Region: SLH; pfam00395 292564007148 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 292564007149 S-layer homology domain; Region: SLH; pfam00395 292564007150 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 292564007151 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 292564007152 HSP70 interaction site [polypeptide binding]; other site 292564007153 Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910 292564007154 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 292564007155 TIGR01777 family protein; Region: yfcH 292564007156 NAD(P) binding site [chemical binding]; other site 292564007157 active site 292564007158 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 292564007159 conserved hypothetical protein; Region: TIGR03492 292564007160 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 292564007161 9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732 292564007162 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 292564007163 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 292564007164 putative hydrophobic ligand binding site [chemical binding]; other site 292564007165 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 292564007166 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 292564007167 active site 292564007168 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 292564007169 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 292564007170 putative metal binding site; other site 292564007171 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292564007172 TPR repeat; Region: TPR_11; pfam13414 292564007173 binding surface 292564007174 TPR motif; other site 292564007175 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 292564007176 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 292564007177 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 292564007178 Protein of unknown function (DUF751); Region: DUF751; pfam05421 292564007179 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 292564007180 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 292564007181 C-terminal domain interface [polypeptide binding]; other site 292564007182 GSH binding site (G-site) [chemical binding]; other site 292564007183 dimer interface [polypeptide binding]; other site 292564007184 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 292564007185 N-terminal domain interface [polypeptide binding]; other site 292564007186 Protein of unknown function (DUF3571); Region: DUF3571; pfam12095 292564007187 shikimate kinase; Reviewed; Region: aroK; PRK00131 292564007188 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 292564007189 ADP binding site [chemical binding]; other site 292564007190 magnesium binding site [ion binding]; other site 292564007191 putative shikimate binding site; other site 292564007192 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 292564007193 active site 292564007194 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 292564007195 active site 292564007196 RibD C-terminal domain; Region: RibD_C; cl17279 292564007197 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 292564007198 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 292564007199 Protein of unknown function, DUF482; Region: DUF482; pfam04339 292564007200 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 292564007201 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 292564007202 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 292564007203 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 292564007204 FeS/SAM binding site; other site 292564007205 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 292564007206 Transmembrane secretion effector; Region: MFS_3; pfam05977 292564007207 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 292564007208 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 292564007209 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 292564007210 FeS/SAM binding site; other site 292564007211 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 292564007212 substrate binding site [chemical binding]; other site 292564007213 putative active site [active] 292564007214 redox center [active] 292564007215 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 292564007216 L-aspartate oxidase; Provisional; Region: PRK07395 292564007217 L-aspartate oxidase; Provisional; Region: PRK06175 292564007218 photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515 292564007219 Protein of unknown function (DUF3120); Region: DUF3120; pfam11318 292564007220 Bacitracin resistance protein BacA; Region: BacA; pfam02673 292564007221 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 292564007222 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 292564007223 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 292564007224 FeS/SAM binding site; other site 292564007225 Protein of unknown function (DUF512); Region: DUF512; pfam04459 292564007226 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 292564007227 PUCC protein; Region: PUCC; pfam03209 292564007228 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 292564007229 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 292564007230 active site 292564007231 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 292564007232 intersubunit interface [polypeptide binding]; other site 292564007233 active site 292564007234 Zn2+ binding site [ion binding]; other site 292564007235 Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229 292564007236 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 292564007237 motif I; other site 292564007238 motif II; other site 292564007239 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 292564007240 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 292564007241 DNA binding site [nucleotide binding] 292564007242 catalytic residue [active] 292564007243 H2TH interface [polypeptide binding]; other site 292564007244 putative catalytic residues [active] 292564007245 turnover-facilitating residue; other site 292564007246 intercalation triad [nucleotide binding]; other site 292564007247 8OG recognition residue [nucleotide binding]; other site 292564007248 putative reading head residues; other site 292564007249 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 292564007250 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 292564007251 photosystem I reaction center subunit IV; Provisional; Region: PRK02749 292564007252 ATP-dependent DNA helicase, RecQ family; Region: recQ_fam; TIGR00614 292564007253 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 292564007254 ATP binding site [chemical binding]; other site 292564007255 putative Mg++ binding site [ion binding]; other site 292564007256 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 292564007257 nucleotide binding region [chemical binding]; other site 292564007258 ATP-binding site [chemical binding]; other site 292564007259 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 292564007260 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 292564007261 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 292564007262 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 292564007263 NAD(P) binding site [chemical binding]; other site 292564007264 catalytic residues [active] 292564007265 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 292564007266 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 292564007267 Dehydroquinase class II; Region: DHquinase_II; pfam01220 292564007268 active site 292564007269 trimer interface [polypeptide binding]; other site 292564007270 dimer interface [polypeptide binding]; other site 292564007271 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 292564007272 active site 292564007273 dinuclear metal binding site [ion binding]; other site 292564007274 dimerization interface [polypeptide binding]; other site 292564007275 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 292564007276 Cupin domain; Region: Cupin_2; pfam07883 292564007277 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 292564007278 active site 292564007279 SAM binding site [chemical binding]; other site 292564007280 homodimer interface [polypeptide binding]; other site 292564007281 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 292564007282 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 292564007283 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 292564007284 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 292564007285 FMN binding site [chemical binding]; other site 292564007286 active site 292564007287 catalytic residues [active] 292564007288 substrate binding site [chemical binding]; other site 292564007289 Domain of unknown function (DUF1823); Region: DUF1823; pfam08853 292564007290 GTP-binding protein Der; Reviewed; Region: PRK00093 292564007291 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 292564007292 G1 box; other site 292564007293 GTP/Mg2+ binding site [chemical binding]; other site 292564007294 Switch I region; other site 292564007295 G2 box; other site 292564007296 Switch II region; other site 292564007297 G3 box; other site 292564007298 G4 box; other site 292564007299 G5 box; other site 292564007300 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 292564007301 G1 box; other site 292564007302 GTP/Mg2+ binding site [chemical binding]; other site 292564007303 Switch I region; other site 292564007304 G2 box; other site 292564007305 G3 box; other site 292564007306 Switch II region; other site 292564007307 G4 box; other site 292564007308 G5 box; other site 292564007309 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 292564007310 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 292564007311 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 292564007312 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 292564007313 catalytic residue [active] 292564007314 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 292564007315 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 292564007316 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 292564007317 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 292564007318 Protein of unknown function (DUF3086); Region: DUF3086; pfam11285 292564007319 Protein of unknown function (DUF3119); Region: DUF3119; pfam11317 292564007320 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 292564007321 Permease; Region: Permease; pfam02405 292564007322 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 292564007323 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 292564007324 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 292564007325 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 292564007326 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 292564007327 active site 292564007328 catalytic site [active] 292564007329 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 292564007330 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 292564007331 IHF dimer interface [polypeptide binding]; other site 292564007332 IHF - DNA interface [nucleotide binding]; other site 292564007333 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 292564007334 active site 292564007335 HIGH motif; other site 292564007336 nucleotide binding site [chemical binding]; other site 292564007337 active site 292564007338 KMSKS motif; other site 292564007339 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 292564007340 Protein of unknown function (DUF3493); Region: DUF3493; pfam11998 292564007341 translation initiation factor IF-2; Region: IF-2; TIGR00487 292564007342 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 292564007343 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 292564007344 G1 box; other site 292564007345 putative GEF interaction site [polypeptide binding]; other site 292564007346 GTP/Mg2+ binding site [chemical binding]; other site 292564007347 Switch I region; other site 292564007348 G2 box; other site 292564007349 G3 box; other site 292564007350 Switch II region; other site 292564007351 G4 box; other site 292564007352 G5 box; other site 292564007353 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 292564007354 Translation-initiation factor 2; Region: IF-2; pfam11987 292564007355 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 292564007356 Protein of unknown function (DUF448); Region: DUF448; pfam04296 292564007357 putative RNA binding cleft [nucleotide binding]; other site 292564007358 transcription elongation factor NusA; Provisional; Region: nusA; PRK12329 292564007359 NusA N-terminal domain; Region: NusA_N; pfam08529 292564007360 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 292564007361 RNA binding site [nucleotide binding]; other site 292564007362 homodimer interface [polypeptide binding]; other site 292564007363 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 292564007364 G-X-X-G motif; other site 292564007365 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 292564007366 G-X-X-G motif; other site 292564007367 Sm and related proteins; Region: Sm_like; cl00259 292564007368 ribosome maturation protein RimP; Reviewed; Region: PRK00092 292564007369 heptamer interface [polypeptide binding]; other site 292564007370 Sm1 motif; other site 292564007371 hexamer interface [polypeptide binding]; other site 292564007372 RNA binding site [nucleotide binding]; other site 292564007373 Sm2 motif; other site 292564007374 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 292564007375 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 292564007376 active site 292564007377 metal binding site [ion binding]; metal-binding site 292564007378 hexamer interface [polypeptide binding]; other site 292564007379 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 292564007380 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 292564007381 protein binding site [polypeptide binding]; other site 292564007382 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 292564007383 tetramer (dimer of dimers) interface [polypeptide binding]; other site 292564007384 active site 292564007385 dimer interface [polypeptide binding]; other site 292564007386 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 292564007387 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 292564007388 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 292564007389 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 292564007390 metal binding site [ion binding]; metal-binding site 292564007391 active site 292564007392 I-site; other site 292564007393 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 292564007394 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 292564007395 histidinol dehydrogenase; Region: hisD; TIGR00069 292564007396 NAD binding site [chemical binding]; other site 292564007397 dimerization interface [polypeptide binding]; other site 292564007398 product binding site; other site 292564007399 substrate binding site [chemical binding]; other site 292564007400 zinc binding site [ion binding]; other site 292564007401 catalytic residues [active] 292564007402 ribosomal protein S20; Region: rps20; CHL00102 292564007403 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 292564007404 active site 292564007405 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 292564007406 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 292564007407 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 292564007408 RPB1 interaction site [polypeptide binding]; other site 292564007409 RPB10 interaction site [polypeptide binding]; other site 292564007410 RPB11 interaction site [polypeptide binding]; other site 292564007411 RPB3 interaction site [polypeptide binding]; other site 292564007412 RPB12 interaction site [polypeptide binding]; other site 292564007413 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 292564007414 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 292564007415 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 292564007416 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 292564007417 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 292564007418 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 292564007419 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 292564007420 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 292564007421 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 292564007422 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 292564007423 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 292564007424 DNA binding site [nucleotide binding] 292564007425 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 292564007426 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457 292564007427 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 292564007428 FeS/SAM binding site; other site 292564007429 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 292564007430 muropeptide transporter; Reviewed; Region: ampG; PRK11902 292564007431 muropeptide transporter; Validated; Region: ampG; cl17669 292564007432 HEAT repeats; Region: HEAT_2; pfam13646 292564007433 HEAT repeats; Region: HEAT_2; pfam13646 292564007434 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 292564007435 Protein of unknown function (DUF1257); Region: DUF1257; pfam06868 292564007436 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 292564007437 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 292564007438 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 292564007439 active site 292564007440 catalytic tetrad [active] 292564007441 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 292564007442 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 292564007443 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 292564007444 HSP70 interaction site [polypeptide binding]; other site 292564007445 Protein of unknown function (DUF3143); Region: DUF3143; pfam11341 292564007446 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 292564007447 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 292564007448 inhibitor-cofactor binding pocket; inhibition site 292564007449 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292564007450 catalytic residue [active] 292564007451 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 292564007452 AAA domain; Region: AAA_26; pfam13500 292564007453 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 292564007454 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 292564007455 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 292564007456 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 292564007457 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 292564007458 catalytic residue [active] 292564007459 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 292564007460 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 292564007461 active site 292564007462 DNA binding site [nucleotide binding] 292564007463 Int/Topo IB signature motif; other site 292564007464 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 292564007465 Putative transposase; Region: Y2_Tnp; pfam04986 292564007466 Homeodomain-like domain; Region: HTH_23; cl17451 292564007467 Winged helix-turn helix; Region: HTH_29; pfam13551 292564007468 Integrase core domain; Region: rve; pfam00665 292564007469 Integrase core domain; Region: rve_3; pfam13683 292564007470 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 292564007471 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 292564007472 Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA; cl00012 292564007473 DEAD-like helicases superfamily; Region: DEXDc; smart00487 292564007474 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 292564007475 ATP binding site [chemical binding]; other site 292564007476 putative Mg++ binding site [ion binding]; other site 292564007477 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 292564007478 nucleotide binding region [chemical binding]; other site 292564007479 ATP-binding site [chemical binding]; other site 292564007480 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 292564007481 adenylosuccinate lyase; Provisional; Region: PRK07380 292564007482 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 292564007483 tetramer interface [polypeptide binding]; other site 292564007484 active site 292564007485 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 292564007486 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 292564007487 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 292564007488 RNA binding surface [nucleotide binding]; other site 292564007489 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 292564007490 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 292564007491 Nitrogen regulatory protein P-II; Region: P-II; smart00938 292564007492 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 292564007493 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 292564007494 ResB-like family; Region: ResB; pfam05140 292564007495 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 292564007496 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 292564007497 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 292564007498 Phycobilisome protein; Region: Phycobilisome; cl08227 292564007499 Phycobilisome protein; Region: Phycobilisome; cl08227 292564007500 Phycobilisome protein; Region: Phycobilisome; cl08227 292564007501 Phycobilisome protein; Region: Phycobilisome; cl08227 292564007502 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 292564007503 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 292564007504 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 292564007505 Methyltransferase domain; Region: Methyltransf_31; pfam13847 292564007506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292564007507 S-adenosylmethionine binding site [chemical binding]; other site 292564007508 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 292564007509 ATP synthase CF0 A subunit; Region: atpI; CHL00046 292564007510 Cyagr_3079; ATPC RNA motif 292564007511 ATP synthase CF0 C subunit; Region: atpH; CHL00061 292564007512 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 292564007513 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 292564007514 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 292564007515 F0F1 ATP synthase subunit B; Validated; Region: PRK07352 292564007516 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 292564007517 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 292564007518 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 292564007519 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 292564007520 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 292564007521 beta subunit interaction interface [polypeptide binding]; other site 292564007522 Walker A motif; other site 292564007523 ATP binding site [chemical binding]; other site 292564007524 Walker B motif; other site 292564007525 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 292564007526 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 292564007527 core domain interface [polypeptide binding]; other site 292564007528 delta subunit interface [polypeptide binding]; other site 292564007529 epsilon subunit interface [polypeptide binding]; other site 292564007530 Sulfatase; Region: Sulfatase; cl17466 292564007531 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 292564007532 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 292564007533 active site 292564007534 DNA binding site [nucleotide binding] 292564007535 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 292564007536 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 292564007537 putative NAD(P) binding site [chemical binding]; other site 292564007538 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 292564007539 Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; pfam13759 292564007540 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 292564007541 catalytic loop [active] 292564007542 iron binding site [ion binding]; other site 292564007543 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 292564007544 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 292564007545 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 292564007546 catalytic triad [active] 292564007547 dimer interface [polypeptide binding]; other site 292564007548 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292564007549 PAS domain; Region: PAS_9; pfam13426 292564007550 putative active site [active] 292564007551 heme pocket [chemical binding]; other site 292564007552 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 292564007553 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 292564007554 metal binding site [ion binding]; metal-binding site 292564007555 active site 292564007556 I-site; other site 292564007557 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 292564007558 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 292564007559 active site 292564007560 dimer interface [polypeptide binding]; other site 292564007561 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 292564007562 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 292564007563 active site 292564007564 HIGH motif; other site 292564007565 dimer interface [polypeptide binding]; other site 292564007566 KMSKS motif; other site 292564007567 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 292564007568 Domain of unknown function (DUF1825); Region: DUF1825; pfam08855 292564007569 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 292564007570 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 292564007571 DNA binding residues [nucleotide binding] 292564007572 dimerization interface [polypeptide binding]; other site 292564007573 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 292564007574 multifunctional aminopeptidase A; Provisional; Region: PRK00913 292564007575 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 292564007576 interface (dimer of trimers) [polypeptide binding]; other site 292564007577 Substrate-binding/catalytic site; other site 292564007578 Zn-binding sites [ion binding]; other site 292564007579 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 292564007580 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 292564007581 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 292564007582 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 292564007583 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 292564007584 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 292564007585 active site 292564007586 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 292564007587 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 292564007588 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 292564007589 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 292564007590 Surface antigen; Region: Bac_surface_Ag; pfam01103 292564007591 Surface antigen; Region: Bac_surface_Ag; pfam01103 292564007592 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 292564007593 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 292564007594 ATP binding site [chemical binding]; other site 292564007595 active site 292564007596 substrate binding site [chemical binding]; other site 292564007597 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 292564007598 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 292564007599 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 292564007600 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 292564007601 HAMP domain; Region: HAMP; pfam00672 292564007602 dimerization interface [polypeptide binding]; other site 292564007603 PAS domain; Region: PAS; smart00091 292564007604 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 292564007605 putative active site [active] 292564007606 heme pocket [chemical binding]; other site 292564007607 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292564007608 dimer interface [polypeptide binding]; other site 292564007609 phosphorylation site [posttranslational modification] 292564007610 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292564007611 ATP binding site [chemical binding]; other site 292564007612 Mg2+ binding site [ion binding]; other site 292564007613 G-X-G motif; other site 292564007614 circadian clock protein KaiC; Region: circ_KaiC; TIGR02655 292564007615 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 292564007616 Walker A motif; other site 292564007617 ATP binding site [chemical binding]; other site 292564007618 Walker B motif; other site 292564007619 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 292564007620 ATP binding site [chemical binding]; other site 292564007621 Walker B motif; other site 292564007622 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 292564007623 tetramer interface [polypeptide binding]; other site 292564007624 dimer interface [polypeptide binding]; other site 292564007625 KaiA domain; Region: KaiA; pfam07688 292564007626 ribosomal protein L21; Region: rpl21; CHL00075 292564007627 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 292564007628 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 292564007629 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 292564007630 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 292564007631 RNA binding site [nucleotide binding]; other site 292564007632 active site 292564007633 hypothetical protein; Validated; Region: PRK00110 292564007634 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 292564007635 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 292564007636 active site 292564007637 trimer interface [polypeptide binding]; other site 292564007638 allosteric site; other site 292564007639 active site lid [active] 292564007640 hexamer (dimer of trimers) interface [polypeptide binding]; other site 292564007641 Stage II sporulation protein; Region: SpoIID; pfam08486 292564007642 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 292564007643 ribonuclease Z; Region: RNase_Z; TIGR02651 292564007644 cytochrome c-550; Provisional; Region: psbV; PRK13617 292564007645 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 292564007646 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 292564007647 catalytic loop [active] 292564007648 iron binding site [ion binding]; other site 292564007649 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 292564007650 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 292564007651 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 292564007652 ligand binding site [chemical binding]; other site 292564007653 NAD binding site [chemical binding]; other site 292564007654 dimerization interface [polypeptide binding]; other site 292564007655 catalytic site [active] 292564007656 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 292564007657 putative L-serine binding site [chemical binding]; other site 292564007658 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 292564007659 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 292564007660 RNA binding surface [nucleotide binding]; other site 292564007661 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705 292564007662 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 292564007663 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 292564007664 Uncharacterized conserved protein [Function unknown]; Region: COG2947 292564007665 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 292564007666 Domain of unknown function (DUF1818); Region: DUF1818; pfam08848 292564007667 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; pfam01192 292564007668 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 292564007669 nucleotide binding site [chemical binding]; other site 292564007670 putative NEF/HSP70 interaction site [polypeptide binding]; other site 292564007671 SBD interface [polypeptide binding]; other site 292564007672 Ferredoxin thioredoxin reductase variable alpha chain; Region: FeThRed_A; pfam02941 292564007673 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 292564007674 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 292564007675 active site 292564007676 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 292564007677 phosphoglyceromutase; Provisional; Region: PRK05434 292564007678 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 292564007679 SelR domain; Region: SelR; pfam01641 292564007680 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 292564007681 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 292564007682 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 292564007683 FeS/SAM binding site; other site 292564007684 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 292564007685 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 292564007686 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 292564007687 ring oligomerisation interface [polypeptide binding]; other site 292564007688 ATP/Mg binding site [chemical binding]; other site 292564007689 stacking interactions; other site 292564007690 hinge regions; other site 292564007691 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 292564007692 oligomerisation interface [polypeptide binding]; other site 292564007693 mobile loop; other site 292564007694 roof hairpin; other site 292564007695 ATP synthase CF1 beta subunit; Region: atpB; CHL00060 292564007696 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 292564007697 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 292564007698 alpha subunit interaction interface [polypeptide binding]; other site 292564007699 Walker A motif; other site 292564007700 ATP binding site [chemical binding]; other site 292564007701 Walker B motif; other site 292564007702 inhibitor binding site; inhibition site 292564007703 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 292564007704 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 292564007705 gamma subunit interface [polypeptide binding]; other site 292564007706 epsilon subunit interface [polypeptide binding]; other site 292564007707 LBP interface [polypeptide binding]; other site 292564007708 FHA domain; Region: FHA; pfam00498 292564007709 phosphopeptide binding site; other site 292564007710 Transglycosylase; Region: Transgly; pfam00912 292564007711 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 292564007712 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 292564007713 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 292564007714 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 292564007715 phosphopeptide binding site; other site 292564007716 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 292564007717 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 292564007718 substrate binding site [chemical binding]; other site 292564007719 activation loop (A-loop); other site 292564007720 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 292564007721 metal ion-dependent adhesion site (MIDAS); other site 292564007722 Protein phosphatase 2C; Region: PP2C_2; pfam13672 292564007723 active site 292564007724 Class I aldolases; Region: Aldolase_Class_I; cl17187 292564007725 catalytic residue [active] 292564007726 hypothetical protein; Provisional; Region: PRK02724 292564007727 haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1 292564007728 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 292564007729 proline aminopeptidase P II; Provisional; Region: PRK10879 292564007730 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 292564007731 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 292564007732 active site 292564007733 Domain of unknown function DUF21; Region: DUF21; pfam01595 292564007734 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 292564007735 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 292564007736 GTP/Mg2+ binding site [chemical binding]; other site 292564007737 Switch I region; other site 292564007738 G2 box; other site 292564007739 Switch II region; other site 292564007740 G3 box; other site 292564007741 G4 box; other site 292564007742 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 292564007743 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 292564007744 active site 292564007745 (T/H)XGH motif; other site 292564007746 NAD synthetase; Provisional; Region: PRK13981 292564007747 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 292564007748 multimer interface [polypeptide binding]; other site 292564007749 active site 292564007750 catalytic triad [active] 292564007751 protein interface 1 [polypeptide binding]; other site 292564007752 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 292564007753 homodimer interface [polypeptide binding]; other site 292564007754 NAD binding pocket [chemical binding]; other site 292564007755 ATP binding pocket [chemical binding]; other site 292564007756 Mg binding site [ion binding]; other site 292564007757 active-site loop [active] 292564007758 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 292564007759 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 292564007760 hexamer interface [polypeptide binding]; other site 292564007761 ligand binding site [chemical binding]; other site 292564007762 putative active site [active] 292564007763 NAD(P) binding site [chemical binding]; other site 292564007764 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 292564007765 Methyltransferase domain; Region: Methyltransf_23; pfam13489 292564007766 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 292564007767 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 292564007768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292564007769 active site 292564007770 phosphorylation site [posttranslational modification] 292564007771 intermolecular recognition site; other site 292564007772 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 292564007773 DNA binding residues [nucleotide binding] 292564007774 dimerization interface [polypeptide binding]; other site 292564007775 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 292564007776 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292564007777 dimer interface [polypeptide binding]; other site 292564007778 phosphorylation site [posttranslational modification] 292564007779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292564007780 ATP binding site [chemical binding]; other site 292564007781 G-X-G motif; other site 292564007782 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 292564007783 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 292564007784 Ligand Binding Site [chemical binding]; other site 292564007785 K+-transporting ATPase, c chain; Region: KdpC; cl00944 292564007786 F subunit of K+-transporting ATPase (Potass_KdpF); Region: Potass_KdpF; pfam09604 292564007787 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 292564007788 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 292564007789 Soluble P-type ATPase [General function prediction only]; Region: COG4087 292564007790 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 292564007791 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 292564007792 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 292564007793 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 292564007794 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 292564007795 putative C-terminal domain interface [polypeptide binding]; other site 292564007796 putative GSH binding site (G-site) [chemical binding]; other site 292564007797 putative dimer interface [polypeptide binding]; other site 292564007798 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 292564007799 putative N-terminal domain interface [polypeptide binding]; other site 292564007800 putative dimer interface [polypeptide binding]; other site 292564007801 putative substrate binding pocket (H-site) [chemical binding]; other site 292564007802 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 292564007803 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 292564007804 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 292564007805 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 292564007806 catalytic site [active] 292564007807 TAP-like protein; Region: Abhydrolase_4; pfam08386 292564007808 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 292564007809 NAD(P) binding site [chemical binding]; other site 292564007810 active site 292564007811 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 292564007812 Protein of unknown function (DUF721); Region: DUF721; pfam05258 292564007813 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 292564007814 active site flap/lid [active] 292564007815 nucleophilic elbow; other site 292564007816 catalytic triad [active] 292564007817 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 292564007818 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 292564007819 catalytic residues [active] 292564007820 succinyldiaminopimelate transaminase; Validated; Region: PRK07366 292564007821 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 292564007822 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292564007823 homodimer interface [polypeptide binding]; other site 292564007824 catalytic residue [active] 292564007825 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 292564007826 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 292564007827 Peptidase family M23; Region: Peptidase_M23; pfam01551 292564007828 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 292564007829 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 292564007830 Walker A/P-loop; other site 292564007831 ATP binding site [chemical binding]; other site 292564007832 Q-loop/lid; other site 292564007833 ABC transporter signature motif; other site 292564007834 Walker B; other site 292564007835 D-loop; other site 292564007836 H-loop/switch region; other site 292564007837 NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504 292564007838 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 292564007839 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 292564007840 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 292564007841 active site 292564007842 metal binding site [ion binding]; metal-binding site 292564007843 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 292564007844 domain I; other site 292564007845 phosphate binding site [ion binding]; other site 292564007846 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 292564007847 domain II; other site 292564007848 domain III; other site 292564007849 nucleotide binding site [chemical binding]; other site 292564007850 DNA binding groove [nucleotide binding] 292564007851 catalytic site [active] 292564007852 domain IV; other site 292564007853 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 292564007854 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 292564007855 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 292564007856 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cl11435 292564007857 putative dimer interface [polypeptide binding]; other site 292564007858 active site pocket [active] 292564007859 putative cataytic base [active] 292564007860 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 292564007861 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 292564007862 active site 292564007863 catalytic tetrad [active] 292564007864 Bifunctional nuclease; Region: DNase-RNase; pfam02577 292564007865 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 292564007866 Lumazine binding domain; Region: Lum_binding; pfam00677 292564007867 Lumazine binding domain; Region: Lum_binding; pfam00677 292564007868 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 292564007869 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 292564007870 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 292564007871 Subunit I/III interface [polypeptide binding]; other site 292564007872 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 292564007873 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 292564007874 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 292564007875 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 292564007876 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 292564007877 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 292564007878 UbiA prenyltransferase family; Region: UbiA; pfam01040 292564007879 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 292564007880 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 292564007881 Walker A/P-loop; other site 292564007882 ATP binding site [chemical binding]; other site 292564007883 Q-loop/lid; other site 292564007884 ABC transporter signature motif; other site 292564007885 Walker B; other site 292564007886 D-loop; other site 292564007887 H-loop/switch region; other site 292564007888 ABC-2 type transporter; Region: ABC2_membrane; cl17235 292564007889 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 292564007890 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 292564007891 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 292564007892 putative active site cavity [active] 292564007893 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 292564007894 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 292564007895 ring oligomerisation interface [polypeptide binding]; other site 292564007896 ATP/Mg binding site [chemical binding]; other site 292564007897 stacking interactions; other site 292564007898 hinge regions; other site 292564007899 Methyltransferase domain; Region: Methyltransf_23; pfam13489 292564007900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292564007901 S-adenosylmethionine binding site [chemical binding]; other site 292564007902 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 292564007903 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 292564007904 active site 292564007905 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 292564007906 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 292564007907 inhibitor-cofactor binding pocket; inhibition site 292564007908 pyridoxal 5'-phosphate binding site [chemical binding]; other site 292564007909 catalytic residue [active] 292564007910 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 292564007911 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 292564007912 NAD(P) binding site [chemical binding]; other site 292564007913 active site 292564007914 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 292564007915 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 292564007916 NAD(P) binding site [chemical binding]; other site 292564007917 homotetramer interface [polypeptide binding]; other site 292564007918 homodimer interface [polypeptide binding]; other site 292564007919 active site 292564007920 Ion channel; Region: Ion_trans_2; pfam07885 292564007921 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 292564007922 TrkA-N domain; Region: TrkA_N; pfam02254 292564007923 TrkA-C domain; Region: TrkA_C; pfam02080 292564007924 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 292564007925 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 292564007926 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 292564007927 substrate binding site; other site 292564007928 dimer interface; other site 292564007929 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 292564007930 dimer interface [polypeptide binding]; other site 292564007931 catalytic triad [active] 292564007932 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 292564007933 UbiA prenyltransferase family; Region: UbiA; pfam01040 292564007934 exopolyphosphatase; Region: exo_poly_only; TIGR03706 292564007935 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 292564007936 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 292564007937 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 292564007938 active site 292564007939 SAM binding site [chemical binding]; other site 292564007940 homodimer interface [polypeptide binding]; other site 292564007941 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 292564007942 apocytochrome f; Reviewed; Region: PRK02693 292564007943 cytochrome f; Region: petA; CHL00037 292564007944 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 292564007945 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 292564007946 Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471 292564007947 cytochrome b subunit interaction site [polypeptide binding]; other site 292564007948 [2Fe-2S] cluster binding site [ion binding]; other site 292564007949 Protein of unknown function (DUF3067); Region: DUF3067; pfam11267 292564007950 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 292564007951 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 292564007952 Domain of unknown function (DUF814); Region: DUF814; pfam05670 292564007953 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 292564007954 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 292564007955 catalytic site [active] 292564007956 G-X2-G-X-G-K; other site 292564007957 Photosystem I reaction centre subunit IX / PsaJ; Region: PSI_PsaJ; cl03320 292564007958 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 292564007959 UGMP family protein; Validated; Region: PRK09604 292564007960 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 292564007961 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 292564007962 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 292564007963 Walker A motif; other site 292564007964 ATP binding site [chemical binding]; other site 292564007965 Walker B motif; other site 292564007966 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 292564007967 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 292564007968 active site 292564007969 homodimer interface [polypeptide binding]; other site 292564007970 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 292564007971 HlyD family secretion protein; Region: HlyD_3; pfam13437 292564007972 GTP-binding protein YchF; Reviewed; Region: PRK09601 292564007973 YchF GTPase; Region: YchF; cd01900 292564007974 G1 box; other site 292564007975 GTP/Mg2+ binding site [chemical binding]; other site 292564007976 Switch I region; other site 292564007977 G2 box; other site 292564007978 Switch II region; other site 292564007979 G3 box; other site 292564007980 G4 box; other site 292564007981 G5 box; other site 292564007982 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 292564007983 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 292564007984 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 292564007985 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 292564007986 Walker A/P-loop; other site 292564007987 ATP binding site [chemical binding]; other site 292564007988 Q-loop/lid; other site 292564007989 ABC transporter signature motif; other site 292564007990 Walker B; other site 292564007991 D-loop; other site 292564007992 H-loop/switch region; other site 292564007993 FtsX-like permease family; Region: FtsX; pfam02687 292564007994 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 292564007995 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 292564007996 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 292564007997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 292564007998 ABC-ATPase subunit interface; other site 292564007999 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 292564008000 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 292564008001 homoserine dehydrogenase; Provisional; Region: PRK06349 292564008002 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 292564008003 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 292564008004 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 292564008005 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 292564008006 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 292564008007 active site 292564008008 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 292564008009 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292564008010 Fe-S metabolism associated domain; Region: SufE; cl00951 292564008011 Transthyretin_like. This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase). TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl17222 292564008012 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 292564008013 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 292564008014 active site 292564008015 putative DNA-binding cleft [nucleotide binding]; other site 292564008016 dimer interface [polypeptide binding]; other site 292564008017 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 292564008018 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 292564008019 Walker A motif; other site 292564008020 ATP binding site [chemical binding]; other site 292564008021 Protein of unknown function (DUF3370); Region: DUF3370; pfam11850 292564008022 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 292564008023 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 292564008024 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 292564008025 Cytochrome c; Region: Cytochrom_C; pfam00034 292564008026 cytochrome b6-f complex subunit PetG; Reviewed; Region: petG; PRK00665 292564008027 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 292564008028 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292564008029 S-adenosylmethionine binding site [chemical binding]; other site 292564008030 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 292564008031 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 292564008032 putative active site [active] 292564008033 oxyanion strand; other site 292564008034 catalytic triad [active] 292564008035 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 292564008036 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 292564008037 catalytic residues [active] 292564008038 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 292564008039 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 292564008040 active site 292564008041 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 292564008042 Domain of unknown function DUF39; Region: DUF39; pfam01837 292564008043 DNA gyrase subunit A; Validated; Region: PRK05560 292564008044 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 292564008045 CAP-like domain; other site 292564008046 active site 292564008047 primary dimer interface [polypeptide binding]; other site 292564008048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 292564008049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 292564008050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 292564008051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 292564008052 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 292564008053 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 292564008054 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 292564008055 lycopene cyclase; Region: lycopene_cycl; TIGR01789 292564008056 malate:quinone oxidoreductase; Validated; Region: PRK05257 292564008057 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 292564008058 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 292564008059 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 292564008060 putative catalytic site [active] 292564008061 putative phosphate binding site [ion binding]; other site 292564008062 active site 292564008063 metal binding site A [ion binding]; metal-binding site 292564008064 DNA binding site [nucleotide binding] 292564008065 putative AP binding site [nucleotide binding]; other site 292564008066 putative metal binding site B [ion binding]; other site 292564008067 hypothetical protein; Provisional; Region: PRK04194 292564008068 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 292564008069 metal binding site 2 [ion binding]; metal-binding site 292564008070 putative DNA binding helix; other site 292564008071 metal binding site 1 [ion binding]; metal-binding site 292564008072 dimer interface [polypeptide binding]; other site 292564008073 structural Zn2+ binding site [ion binding]; other site 292564008074 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 292564008075 non-specific DNA interactions [nucleotide binding]; other site 292564008076 DNA binding site [nucleotide binding] 292564008077 sequence specific DNA binding site [nucleotide binding]; other site 292564008078 putative cAMP binding site [chemical binding]; other site 292564008079 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 292564008080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 292564008081 ABC-ATPase subunit interface; other site 292564008082 putative PBP binding loops; other site 292564008083 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 292564008084 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 292564008085 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 292564008086 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 292564008087 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 292564008088 tellurite resistance protein terB; Region: terB; cd07176 292564008089 putative metal binding site [ion binding]; other site 292564008090 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 292564008091 metal binding site 2 [ion binding]; metal-binding site 292564008092 putative DNA binding helix; other site 292564008093 metal binding site 1 [ion binding]; metal-binding site 292564008094 dimer interface [polypeptide binding]; other site 292564008095 structural Zn2+ binding site [ion binding]; other site 292564008096 TIGR03943 family protein; Region: TIGR03943 292564008097 Predicted permease; Region: DUF318; cl17795 292564008098 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 292564008099 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 292564008100 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 292564008101 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 292564008102 metal binding site [ion binding]; metal-binding site 292564008103 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 292564008104 YcfA-like protein; Region: YcfA; pfam07927 292564008105 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 292564008106 NADH(P)-binding; Region: NAD_binding_10; pfam13460 292564008107 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 292564008108 NAD(P) binding site [chemical binding]; other site 292564008109 putative active site [active] 292564008110 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 292564008111 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 292564008112 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 292564008113 active site 292564008114 Predicted membrane protein (DUF2214); Region: DUF2214; pfam09980 292564008115 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 292564008116 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 292564008117 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 292564008118 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 292564008119 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 292564008120 DNA binding residues [nucleotide binding] 292564008121 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 292564008122 Phosphate-starvation-inducible E; Region: PsiE; pfam06146 292564008123 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 292564008124 nif11 domain/cupin domain protein; Region: nif11_cupin; TIGR03890 292564008125 Cupin; Region: Cupin_6; pfam12852 292564008126 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 292564008127 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 292564008128 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 292564008129 Cytochrome c; Region: Cytochrom_C; cl11414 292564008130 YCII-related domain; Region: YCII; cl00999 292564008131 Protein of unknown function (DUF938); Region: DUF938; pfam06080 292564008132 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 292564008133 substrate binding site [chemical binding]; other site 292564008134 active site 292564008135 catalytic residues [active] 292564008136 heterodimer interface [polypeptide binding]; other site 292564008137 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 292564008138 NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716 292564008139 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 292564008140 active site 292564008141 catalytic residues [active] 292564008142 DNA binding site [nucleotide binding] 292564008143 Int/Topo IB signature motif; other site 292564008144 D5 N terminal like; Region: D5_N; smart00885 292564008145 Phage associated DNA primase [General function prediction only]; Region: COG3378 292564008146 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 292564008147 generic binding surface II; other site 292564008148 Domain of unknown function (DUF932); Region: DUF932; cl12129 292564008149 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 292564008150 dimer interface [polypeptide binding]; other site 292564008151 phosphorylation site [posttranslational modification] 292564008152 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 292564008153 ATP binding site [chemical binding]; other site 292564008154 Mg2+ binding site [ion binding]; other site 292564008155 G-X-G motif; other site 292564008156 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 292564008157 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 292564008158 active site 292564008159 phosphorylation site [posttranslational modification] 292564008160 intermolecular recognition site; other site 292564008161 dimerization interface [polypeptide binding]; other site 292564008162 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 292564008163 DNA binding site [nucleotide binding] 292564008164 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 292564008165 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 292564008166 Protein export membrane protein; Region: SecD_SecF; cl14618 292564008167 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 292564008168 EamA-like transporter family; Region: EamA; pfam00892 292564008169 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 292564008170 putative active site [active] 292564008171 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 292564008172 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 292564008173 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 292564008174 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 292564008175 S-adenosylmethionine binding site [chemical binding]; other site 292564008176 manganese transport protein MntH; Reviewed; Region: PRK00701 292564008177 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 292564008178 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 292564008179 substrate binding site [chemical binding]; other site 292564008180 putative active site [active] 292564008181 redox center [active] 292564008182 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 292564008183 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 292564008184 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 292564008185 DNA binding residues [nucleotide binding] 292564008186 dimer interface [polypeptide binding]; other site 292564008187 putative metal binding site [ion binding]; other site 292564008188 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 292564008189 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 292564008190 Soluble P-type ATPase [General function prediction only]; Region: COG4087 292564008191 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 292564008192 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 292564008193 Multicopper oxidase; Region: Cu-oxidase; pfam00394 292564008194 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 292564008195 Protein of unknown function, DUF; Region: DUF411; cl01142 292564008196 Glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]; Region: GrxC; COG0695 292564008197 TPR repeat; Region: TPR_11; pfam13414 292564008198 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 292564008199 binding surface 292564008200 TPR motif; other site 292564008201 TPR repeat; Region: TPR_11; pfam13414 292564008202 Domain of unknown function (DUF305); Region: DUF305; pfam03713 292564008203 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 292564008204 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 292564008205 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 292564008206 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 292564008207 motif II; other site 292564008208 Protein of unknown function; Region: DUF3721; pfam12518 292564008209 Protein of unknown function; Region: DUF3721; pfam12518 292564008210 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 292564008211 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 292564008212 DNA binding residues [nucleotide binding] 292564008213 dimer interface [polypeptide binding]; other site 292564008214 metal binding site [ion binding]; metal-binding site 292564008215 Domain of unknown function (DUF305); Region: DUF305; pfam03713 292564008216 Domain of unknown function DUF302; Region: DUF302; cl01364 292564008217 Protein of unknown function (DUF2459); Region: DUF2459; cl09819 292564008218 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 292564008219 DJ-1 family protein; Region: not_thiJ; TIGR01383 292564008220 conserved cys residue [active] 292564008221 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 292564008222 dimer interface [polypeptide binding]; other site 292564008223 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 292564008224 metal binding site [ion binding]; metal-binding site 292564008225 PAS fold; Region: PAS; pfam00989 292564008226 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292564008227 putative active site [active] 292564008228 heme pocket [chemical binding]; other site 292564008229 PAS domain S-box; Region: sensory_box; TIGR00229 292564008230 PAS domain; Region: PAS; smart00091 292564008231 putative active site [active] 292564008232 PAS fold; Region: PAS_4; pfam08448 292564008233 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 292564008234 putative active site [active] 292564008235 heme pocket [chemical binding]; other site 292564008236 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 292564008237 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 292564008238 metal binding site [ion binding]; metal-binding site 292564008239 active site 292564008240 I-site; other site 292564008241 bidirectional hydrogenase complex protein HoxE; Reviewed; Region: PRK07571 292564008242 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 292564008243 putative dimer interface [polypeptide binding]; other site 292564008244 [2Fe-2S] cluster binding site [ion binding]; other site 292564008245 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 292564008246 dimer interface [polypeptide binding]; other site 292564008247 [2Fe-2S] cluster binding site [ion binding]; other site 292564008248 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 292564008249 SLBB domain; Region: SLBB; pfam10531 292564008250 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 292564008251 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 292564008252 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 292564008253 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 292564008254 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 292564008255 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 292564008256 Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066 292564008257 nickel binding site [ion binding]; other site 292564008258 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 292564008259 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 292564008260 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 292564008261 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 292564008262 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 292564008263 Acylphosphatase; Region: Acylphosphatase; pfam00708 292564008264 HypF finger; Region: zf-HYPF; pfam07503 292564008265 HypF finger; Region: zf-HYPF; pfam07503 292564008266 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 292564008267 HupF/HypC family; Region: HupF_HypC; pfam01455 292564008268 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 292564008269 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 292564008270 dimer interface [polypeptide binding]; other site 292564008271 PYR/PP interface [polypeptide binding]; other site 292564008272 TPP binding site [chemical binding]; other site 292564008273 substrate binding site [chemical binding]; other site 292564008274 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 292564008275 Domain of unknown function; Region: EKR; pfam10371 292564008276 4Fe-4S binding domain; Region: Fer4_6; pfam12837 292564008277 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 292564008278 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 292564008279 TPP-binding site [chemical binding]; other site 292564008280 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 292564008281 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 292564008282 putative active site [active] 292564008283 putative FMN binding site [chemical binding]; other site 292564008284 putative substrate binding site [chemical binding]; other site 292564008285 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 292564008286 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 292564008287 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 292564008288 dimerization interface [polypeptide binding]; other site 292564008289 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 292564008290 ATP binding site [chemical binding]; other site 292564008291 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 292564008292 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 292564008293 putative dimer interface [polypeptide binding]; other site 292564008294 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 292564008295 sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; Region: ATPase-IIC_X-K; TIGR01106 292564008296 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 292564008297 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 292564008298 Soluble P-type ATPase [General function prediction only]; Region: COG4087 292564008299 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 292564008300 TraB family; Region: TraB; pfam01963 292564008301 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 292564008302 Protein of unknown function (DUF3136); Region: DUF3136; pfam11334 292564008303 bifunctional orotidine 5'-phosphate decarboxylase/orotate phosphoribosyltransferase protein; Validated; Region: PRK05500 292564008304 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 292564008305 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 292564008306 active site 292564008307 malate dehydrogenase; Provisional; Region: PRK13529 292564008308 Malic enzyme, N-terminal domain; Region: malic; pfam00390 292564008309 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 292564008310 NAD(P) binding pocket [chemical binding]; other site 292564008311 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 292564008312 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 292564008313 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 292564008314 Protein of unknown function (DUF552); Region: DUF552; pfam04472 292564008315 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 292564008316 homotrimer interaction site [polypeptide binding]; other site 292564008317 putative active site [active] 292564008318 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 292564008319 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 292564008320 Walker A/P-loop; other site 292564008321 ATP binding site [chemical binding]; other site 292564008322 Q-loop/lid; other site 292564008323 ABC transporter signature motif; other site 292564008324 Walker B; other site 292564008325 D-loop; other site 292564008326 H-loop/switch region; other site 292564008327 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 292564008328 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 292564008329 ligand binding site [chemical binding]; other site 292564008330 flexible hinge region; other site 292564008331 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 292564008332 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 292564008333 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 292564008334 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 292564008335 anti sigma factor interaction site; other site 292564008336 regulatory phosphorylation site [posttranslational modification]; other site 292564008337 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 292564008338 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 292564008339 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 292564008340 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 292564008341 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 292564008342 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 292564008343 Walker A/P-loop; other site 292564008344 ATP binding site [chemical binding]; other site 292564008345 Q-loop/lid; other site 292564008346 ABC transporter signature motif; other site 292564008347 Walker B; other site 292564008348 D-loop; other site 292564008349 H-loop/switch region; other site 292564008350 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 292564008351 Serine hydrolase; Region: Ser_hydrolase; cl17834 292564008352 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 292564008353 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 292564008354 Coenzyme A binding pocket [chemical binding]; other site 292564008355 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 292564008356 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 292564008357 Probable Catalytic site; other site 292564008358 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 292564008359 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 292564008360 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 292564008361 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 292564008362 protein binding site [polypeptide binding]; other site