-- dump date 20140619_054535 -- class Genbank::misc_feature -- table misc_feature_note -- id note 43989000001 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 43989000002 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 43989000003 ParA-like protein; Provisional; Region: PHA02518 43989000004 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 43989000005 P-loop; other site 43989000006 Magnesium ion binding site [ion binding]; other site 43989000007 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 43989000008 FOG: CBS domain [General function prediction only]; Region: COG0517 43989000009 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 43989000010 CP12 domain; Region: CP12; pfam02672 43989000011 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 43989000012 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 43989000013 active site 43989000014 putative DNA-binding cleft [nucleotide binding]; other site 43989000015 dimer interface [polypeptide binding]; other site 43989000016 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 43989000017 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 43989000018 Phage integrase family; Region: Phage_integrase; pfam00589 43989000019 active site 43989000020 DNA binding site [nucleotide binding] 43989000021 Int/Topo IB signature motif; other site 43989000022 T5orf172 domain; Region: T5orf172; pfam10544 43989000023 AAA domain; Region: AAA_30; pfam13604 43989000024 Family description; Region: UvrD_C_2; pfam13538 43989000025 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 43989000026 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 43989000027 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 43989000028 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 43989000029 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 43989000030 catalytic residue [active] 43989000031 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 43989000032 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 43989000033 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 43989000034 AAA domain; Region: AAA_21; pfam13304 43989000035 Walker A/P-loop; other site 43989000036 ATP binding site [chemical binding]; other site 43989000037 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 43989000038 Walker B; other site 43989000039 D-loop; other site 43989000040 H-loop/switch region; other site 43989000041 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 43989000042 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 43989000043 Uncharacterized conserved protein [Function unknown]; Region: COG2442 43989000044 Protein of unknown function (DUF4007); Region: DUF4007; pfam13182 43989000045 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 43989000046 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 43989000047 P-loop; other site 43989000048 Magnesium ion binding site [ion binding]; other site 43989000049 Origin of replication binding protein; Region: Herpes_ori_bp; pfam02399 43989000050 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 43989000051 putative addiction module antidote; Region: doc_partner; TIGR02609 43989000052 TrwC relaxase; Region: TrwC; pfam08751 43989000053 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 43989000054 AAA domain; Region: AAA_30; pfam13604 43989000055 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 43989000056 nucleotide binding site [chemical binding]; other site 43989000057 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 43989000058 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 43989000059 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 43989000060 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 43989000061 putative dimer interface [polypeptide binding]; other site 43989000062 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 43989000063 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 43989000064 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 43989000065 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 43989000066 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 43989000067 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 43989000068 Zeta toxin; Region: Zeta_toxin; pfam06414 43989000069 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 43989000070 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 43989000071 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 43989000072 active site 43989000073 DNA binding site [nucleotide binding] 43989000074 Int/Topo IB signature motif; other site 43989000075 Calx-beta domain; Region: Calx-beta; cl02522 43989000076 Calx-beta domain; Region: Calx-beta; cl02522 43989000077 Calx-beta domain; Region: Calx-beta; cl02522 43989000078 Calx-beta domain; Region: Calx-beta; cl02522 43989000079 Calx-beta domain; Region: Calx-beta; cl02522 43989000080 MobA/MobL family; Region: MobA_MobL; pfam03389 43989000081 Conjugal transfer protein TraD; Region: TraD; cl05753 43989000082 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 43989000083 L11 interface [polypeptide binding]; other site 43989000084 putative EF-Tu interaction site [polypeptide binding]; other site 43989000085 putative EF-G interaction site [polypeptide binding]; other site 43989000086 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 43989000087 active site 43989000088 catalytic residues [active] 43989000089 Int/Topo IB signature motif; other site 43989000090 DNA binding site [nucleotide binding] 43989000091 Uncharacterized conserved protein [Function unknown]; Region: COG2433 43989000092 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 43989000093 active site 43989000094 catalytic residues [active] 43989000095 DNA binding site [nucleotide binding] 43989000096 Int/Topo IB signature motif; other site 43989000097 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 43989000098 oligomeric interface; other site 43989000099 putative active site [active] 43989000100 homodimer interface [polypeptide binding]; other site 43989000101 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 43989000102 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 43989000103 active site 43989000104 catalytic residues [active] 43989000105 DNA binding site [nucleotide binding] 43989000106 Int/Topo IB signature motif; other site 43989000107 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 43989000108 putative DNA binding site [nucleotide binding]; other site 43989000109 putative Zn2+ binding site [ion binding]; other site 43989000110 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 43989000111 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 43989000112 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188 43989000113 active site 43989000114 metal binding site [ion binding]; metal-binding site 43989000115 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 43989000116 Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085 43989000117 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 43989000118 GIY-YIG motif/motif A; other site 43989000119 active site 43989000120 catalytic site [active] 43989000121 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 43989000122 Firmicute plasmid replication protein (RepL); Region: RepL; pfam05732 43989000123 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 43989000124 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 43989000125 putative acyl-acceptor binding pocket; other site 43989000126 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 43989000127 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 43989000128 putative NAD(P) binding site [chemical binding]; other site 43989000129 putative substrate binding site [chemical binding]; other site 43989000130 catalytic Zn binding site [ion binding]; other site 43989000131 structural Zn binding site [ion binding]; other site 43989000132 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 43989000133 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 43989000134 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 43989000135 catalytic residue [active] 43989000136 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 43989000137 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 43989000138 XisI protein; Region: XisI; pfam08869 43989000139 XisH protein; Region: XisH; pfam08814 43989000140 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 43989000141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989000142 active site 43989000143 phosphorylation site [posttranslational modification] 43989000144 intermolecular recognition site; other site 43989000145 dimerization interface [polypeptide binding]; other site 43989000146 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 43989000147 DNA binding site [nucleotide binding] 43989000148 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 43989000149 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 43989000150 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 43989000151 non-specific DNA binding site [nucleotide binding]; other site 43989000152 salt bridge; other site 43989000153 sequence-specific DNA binding site [nucleotide binding]; other site 43989000154 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989000155 dimer interface [polypeptide binding]; other site 43989000156 phosphorylation site [posttranslational modification] 43989000157 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989000158 ATP binding site [chemical binding]; other site 43989000159 Mg2+ binding site [ion binding]; other site 43989000160 G-X-G motif; other site 43989000161 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 43989000162 Peptidase family M50; Region: Peptidase_M50; pfam02163 43989000163 active site 43989000164 putative substrate binding region [chemical binding]; other site 43989000165 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 43989000166 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 43989000167 conserved hypothetical protein; Region: TIGR03492 43989000168 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 43989000169 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989000170 binding surface 43989000171 TPR motif; other site 43989000172 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 43989000173 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 43989000174 PIN domain; Region: PIN_2; pfam10130 43989000175 Endonuclease, Uma2 family (restriction endonuclease fold) [General function prediction only]; Region: Uma2; COG4636 43989000176 putative active site [active] 43989000177 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 43989000178 synthetase active site [active] 43989000179 NTP binding site [chemical binding]; other site 43989000180 metal binding site [ion binding]; metal-binding site 43989000181 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989000182 putative active site [active] 43989000183 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989000184 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 43989000185 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989000186 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989000187 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989000188 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989000189 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 43989000190 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 43989000191 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 43989000192 metal binding site [ion binding]; metal-binding site 43989000193 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 43989000194 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 43989000195 G1 box; other site 43989000196 GTP/Mg2+ binding site [chemical binding]; other site 43989000197 Switch I region; other site 43989000198 G2 box; other site 43989000199 G3 box; other site 43989000200 Switch II region; other site 43989000201 G4 box; other site 43989000202 G5 box; other site 43989000203 Nucleoside recognition; Region: Gate; pfam07670 43989000204 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 43989000205 Nucleoside recognition; Region: Gate; pfam07670 43989000206 FeoA domain; Region: FeoA; pfam04023 43989000207 Uncharacterized conserved protein [Function unknown]; Region: COG3461 43989000208 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 43989000209 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 43989000210 hexamer interface [polypeptide binding]; other site 43989000211 ligand binding site [chemical binding]; other site 43989000212 putative active site [active] 43989000213 NAD(P) binding site [chemical binding]; other site 43989000214 Prefoldin subunit; Region: Prefoldin_2; pfam01920 43989000215 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 43989000216 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 43989000217 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 43989000218 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 43989000219 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 43989000220 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 43989000221 active site 43989000222 motif I; other site 43989000223 motif II; other site 43989000224 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 43989000225 dimer interface [polypeptide binding]; other site 43989000226 active site 43989000227 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 43989000228 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 43989000229 NAD(P) binding site [chemical binding]; other site 43989000230 active site 43989000231 DDE superfamily endonuclease; Region: DDE_3; pfam13358 43989000232 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 43989000233 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 43989000234 Homeodomain-like domain; Region: HTH_32; pfam13565 43989000235 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989000236 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 43989000237 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 43989000238 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 43989000239 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 43989000240 Putative esterase; Region: Esterase; pfam00756 43989000241 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 43989000242 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 43989000243 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 43989000244 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 43989000245 Zn2+ binding site [ion binding]; other site 43989000246 Mg2+ binding site [ion binding]; other site 43989000247 S-layer homology domain; Region: SLH; pfam00395 43989000248 Protein of unknown function (DUF3754); Region: DUF3754; pfam12576 43989000249 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 43989000250 Predicted permease; Region: DUF318; cl17795 43989000251 FAD binding domain; Region: FAD_binding_4; pfam01565 43989000252 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 43989000253 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 43989000254 dimer interface [polypeptide binding]; other site 43989000255 ADP-ribose binding site [chemical binding]; other site 43989000256 active site 43989000257 nudix motif; other site 43989000258 metal binding site [ion binding]; metal-binding site 43989000259 Holliday junction resolvasome, endonuclease subunit [DNA replication, recombination, and repair]; Region: RuvC; COG0817 43989000260 active site 43989000261 putative DNA-binding cleft [nucleotide binding]; other site 43989000262 dimer interface [polypeptide binding]; other site 43989000263 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 43989000264 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 43989000265 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 43989000266 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 43989000267 transmembrane helices; other site 43989000268 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 43989000269 transmembrane helices; other site 43989000270 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 43989000271 TrkA-C domain; Region: TrkA_C; pfam02080 43989000272 TrkA-C domain; Region: TrkA_C; pfam02080 43989000273 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 43989000274 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 43989000275 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 43989000276 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 43989000277 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 43989000278 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 43989000279 motif II; other site 43989000280 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 43989000281 Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932 43989000282 ydaO/yuaA leader; Rfam score 43.60 43989000283 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 43989000284 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 43989000285 G1 box; other site 43989000286 GTP/Mg2+ binding site [chemical binding]; other site 43989000287 Switch I region; other site 43989000288 G2 box; other site 43989000289 Switch II region; other site 43989000290 G3 box; other site 43989000291 G4 box; other site 43989000292 G5 box; other site 43989000293 Domain of unknown function (DUF697); Region: DUF697; pfam05128 43989000294 YGGT family; Region: YGGT; pfam02325 43989000295 Predicted integral membrane protein [Function unknown]; Region: COG0392 43989000296 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 43989000297 putative active site [active] 43989000298 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 43989000299 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 43989000300 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 43989000301 substrate binding pocket [chemical binding]; other site 43989000302 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 43989000303 B12 binding site [chemical binding]; other site 43989000304 cobalt ligand [ion binding]; other site 43989000305 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 43989000306 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 43989000307 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 43989000308 Cl- selectivity filter; other site 43989000309 Cl- binding residues [ion binding]; other site 43989000310 pore gating glutamate residue; other site 43989000311 dimer interface [polypeptide binding]; other site 43989000312 H+/Cl- coupling transport residue; other site 43989000313 FOG: CBS domain [General function prediction only]; Region: COG0517 43989000314 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 43989000315 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 43989000316 Ligand Binding Site [chemical binding]; other site 43989000317 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 43989000318 Ligand Binding Site [chemical binding]; other site 43989000319 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 43989000320 C-terminal peptidase (prc); Region: prc; TIGR00225 43989000321 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 43989000322 protein binding site [polypeptide binding]; other site 43989000323 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 43989000324 Catalytic dyad [active] 43989000325 ribosomal protein S14; Region: rps14; CHL00074 43989000326 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 43989000327 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 43989000328 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989000329 S-adenosylmethionine binding site [chemical binding]; other site 43989000330 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 43989000331 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 43989000332 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 43989000333 Myxococcus xanthus DevT and related proteins, metallophosphatase domain; Region: MPP_DevT; cd07397 43989000334 putative active site [active] 43989000335 putative metal binding site [ion binding]; other site 43989000336 Protein of unknown function (DUF3172); Region: DUF3172; pfam11371 43989000337 Uncharacterized conserved protein [Function unknown]; Region: COG5464 43989000338 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 43989000339 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 43989000340 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989000341 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989000342 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 43989000343 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 43989000344 TrkA-N domain; Region: TrkA_N; pfam02254 43989000345 TIR domain; Region: TIR_2; pfam13676 43989000346 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 43989000347 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 43989000348 nudix motif; other site 43989000349 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 43989000350 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 43989000351 GTP binding site; other site 43989000352 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 43989000353 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 43989000354 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 43989000355 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 43989000356 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 43989000357 tetramer (dimer of dimers) interface [polypeptide binding]; other site 43989000358 active site 43989000359 dimer interface [polypeptide binding]; other site 43989000360 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 43989000361 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 43989000362 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 43989000363 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 43989000364 active site 43989000365 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 43989000366 putative active site [active] 43989000367 putative metal binding site [ion binding]; other site 43989000368 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 43989000369 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 43989000370 Probable transposase; Region: OrfB_IS605; pfam01385 43989000371 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 43989000372 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989000373 putative active site [active] 43989000374 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 43989000375 Exoribonuclease R [Transcription]; Region: VacB; COG0557 43989000376 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 43989000377 RNB domain; Region: RNB; pfam00773 43989000378 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 43989000379 RNA binding site [nucleotide binding]; other site 43989000380 Acylphosphatase; Region: Acylphosphatase; pfam00708 43989000381 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 43989000382 HypF finger; Region: zf-HYPF; pfam07503 43989000383 HypF finger; Region: zf-HYPF; pfam07503 43989000384 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 43989000385 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 43989000386 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 43989000387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989000388 active site 43989000389 phosphorylation site [posttranslational modification] 43989000390 intermolecular recognition site; other site 43989000391 dimerization interface [polypeptide binding]; other site 43989000392 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 43989000393 Zn2+ binding site [ion binding]; other site 43989000394 Mg2+ binding site [ion binding]; other site 43989000395 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 43989000396 SnoaL-like domain; Region: SnoaL_2; pfam12680 43989000397 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 43989000398 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 43989000399 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 43989000400 META domain; Region: META; pfam03724 43989000401 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 43989000402 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 43989000403 dimer interface [polypeptide binding]; other site 43989000404 ABC-ATPase subunit interface; other site 43989000405 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 43989000406 thiamine monophosphate kinase; Provisional; Region: PRK05731 43989000407 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 43989000408 ATP binding site [chemical binding]; other site 43989000409 dimerization interface [polypeptide binding]; other site 43989000410 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 43989000411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 43989000412 dimer interface [polypeptide binding]; other site 43989000413 conserved gate region; other site 43989000414 ABC-ATPase subunit interface; other site 43989000415 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 43989000416 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 43989000417 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 43989000418 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 43989000419 Bacterial sugar transferase; Region: Bac_transf; pfam02397 43989000420 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 43989000421 CAAX protease self-immunity; Region: Abi; pfam02517 43989000422 Protein of unknown function (DUF3531); Region: DUF3531; pfam12049 43989000423 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 43989000424 AMIN domain; Region: AMIN; pfam11741 43989000425 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 43989000426 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 43989000427 active site 43989000428 metal binding site [ion binding]; metal-binding site 43989000429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989000430 S-adenosylmethionine binding site [chemical binding]; other site 43989000431 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 43989000432 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 43989000433 dimer interface [polypeptide binding]; other site 43989000434 decamer (pentamer of dimers) interface [polypeptide binding]; other site 43989000435 catalytic triad [active] 43989000436 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 43989000437 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 43989000438 hydrolase, alpha/beta fold family protein; Region: PLN02824 43989000439 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 43989000440 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 43989000441 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 43989000442 putative acyl-acceptor binding pocket; other site 43989000443 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989000444 putative active site [active] 43989000445 Methyltransferase domain; Region: Methyltransf_31; pfam13847 43989000446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989000447 S-adenosylmethionine binding site [chemical binding]; other site 43989000448 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 43989000449 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 43989000450 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 43989000451 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 43989000452 Endonuclease, Uma2 family (restriction endonuclease fold) [General function prediction only]; Region: Uma2; COG4636 43989000453 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 43989000454 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 43989000455 Zn binding site [ion binding]; other site 43989000456 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 43989000457 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 43989000458 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 43989000459 tetramer interface [polypeptide binding]; other site 43989000460 dimer interface [polypeptide binding]; other site 43989000461 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 43989000462 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 43989000463 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 43989000464 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 43989000465 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 43989000466 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 43989000467 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 43989000468 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 43989000469 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 43989000470 motif II; other site 43989000471 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 43989000472 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 43989000473 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 43989000474 active site 43989000475 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 43989000476 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 43989000477 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 43989000478 NADP binding site [chemical binding]; other site 43989000479 active site 43989000480 putative substrate binding site [chemical binding]; other site 43989000481 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 43989000482 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 43989000483 active site 43989000484 motif I; other site 43989000485 motif II; other site 43989000486 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 43989000487 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 43989000488 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 43989000489 30S subunit binding site; other site 43989000490 Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321 43989000491 Domain of unknown function (DUF427); Region: DUF427; cl00998 43989000492 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 43989000493 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 43989000494 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 43989000495 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 43989000496 MOSC domain; Region: MOSC; pfam03473 43989000497 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 43989000498 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 43989000499 GAF domain; Region: GAF_3; pfam13492 43989000500 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 43989000501 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989000502 dimer interface [polypeptide binding]; other site 43989000503 phosphorylation site [posttranslational modification] 43989000504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989000505 ATP binding site [chemical binding]; other site 43989000506 Mg2+ binding site [ion binding]; other site 43989000507 G-X-G motif; other site 43989000508 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 43989000509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989000510 active site 43989000511 phosphorylation site [posttranslational modification] 43989000512 intermolecular recognition site; other site 43989000513 dimerization interface [polypeptide binding]; other site 43989000514 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 43989000515 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 43989000516 Ligand Binding Site [chemical binding]; other site 43989000517 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 43989000518 putative lipid kinase; Reviewed; Region: PRK13057 43989000519 CP12 domain; Region: CP12; pfam02672 43989000520 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 43989000521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 43989000522 Predicted kinase [General function prediction only]; Region: COG0645 43989000523 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 43989000524 ATP-binding site [chemical binding]; other site 43989000525 Gluconate-6-phosphate binding site [chemical binding]; other site 43989000526 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 43989000527 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 43989000528 inhibitor-cofactor binding pocket; inhibition site 43989000529 pyridoxal 5'-phosphate binding site [chemical binding]; other site 43989000530 catalytic residue [active] 43989000531 methionine sulfoxide reductase B; Provisional; Region: PRK00222 43989000532 SelR domain; Region: SelR; pfam01641 43989000533 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 43989000534 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 43989000535 C-terminal domain interface [polypeptide binding]; other site 43989000536 GSH binding site (G-site) [chemical binding]; other site 43989000537 dimer interface [polypeptide binding]; other site 43989000538 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 43989000539 N-terminal domain interface [polypeptide binding]; other site 43989000540 Predicted GTPase [General function prediction only]; Region: COG2403 43989000541 CsbD-like; Region: CsbD; pfam05532 43989000542 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 43989000543 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 43989000544 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 43989000545 PLD-like domain; Region: PLDc_2; pfam13091 43989000546 putative active site [active] 43989000547 catalytic site [active] 43989000548 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 43989000549 PLD-like domain; Region: PLDc_2; pfam13091 43989000550 putative active site [active] 43989000551 catalytic site [active] 43989000552 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 43989000553 Stage II sporulation protein; Region: SpoIID; pfam08486 43989000554 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 43989000555 Transposase; Region: HTH_Tnp_1; cl17663 43989000556 Transposase; Region: DDE_Tnp_ISL3; pfam01610 43989000557 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 43989000558 DDE superfamily endonuclease; Region: DDE_3; pfam13358 43989000559 Homeodomain-like domain; Region: HTH_23; pfam13384 43989000560 Predicted periplasmic protein (DUF2092); Region: DUF2092; cl17607 43989000561 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 43989000562 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 43989000563 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 43989000564 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 43989000565 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 43989000566 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 43989000567 Transcriptional regulator [Transcription]; Region: LysR; COG0583 43989000568 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 43989000569 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 43989000570 dimerization interface [polypeptide binding]; other site 43989000571 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 43989000572 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 43989000573 Walker A motif; other site 43989000574 ATP binding site [chemical binding]; other site 43989000575 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 43989000576 Domain of unknown function DUF20; Region: UPF0118; pfam01594 43989000577 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 43989000578 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 43989000579 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 43989000580 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 43989000581 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 43989000582 catalytic residue [active] 43989000583 acyl-CoA synthetase; Validated; Region: PRK05850 43989000584 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 43989000585 acyl-activating enzyme (AAE) consensus motif; other site 43989000586 active site 43989000587 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 43989000588 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242 43989000589 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 43989000590 putative NAD(P) binding site [chemical binding]; other site 43989000591 catalytic Zn binding site [ion binding]; other site 43989000592 structural Zn binding site [ion binding]; other site 43989000593 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 43989000594 hydrophobic ligand binding site; other site 43989000595 UGMP family protein; Validated; Region: PRK09604 43989000596 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 43989000597 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 43989000598 Mechanosensitive ion channel; Region: MS_channel; pfam00924 43989000599 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 43989000600 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 43989000601 dimer interface [polypeptide binding]; other site 43989000602 pyridoxal 5'-phosphate binding site [chemical binding]; other site 43989000603 catalytic residue [active] 43989000604 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 43989000605 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 43989000606 active site 43989000607 hypothetical protein; Provisional; Region: PRK06850 43989000608 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 43989000609 Active Sites [active] 43989000610 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 43989000611 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 43989000612 Walker A/P-loop; other site 43989000613 ATP binding site [chemical binding]; other site 43989000614 Haemagglutinin; Region: Hemagglutinin; pfam00509 43989000615 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 43989000616 Q-loop/lid; other site 43989000617 ABC transporter signature motif; other site 43989000618 Walker B; other site 43989000619 D-loop; other site 43989000620 H-loop/switch region; other site 43989000621 Domain of unknown function (DUF1832); Region: DUF1832; pfam08870 43989000622 Domain of unknown function DUF29; Region: DUF29; pfam01724 43989000623 Domain of unknown function DUF29; Region: DUF29; pfam01724 43989000624 ribosomal protein S4; Reviewed; Region: rps4; CHL00113 43989000625 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 43989000626 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 43989000627 RNA binding surface [nucleotide binding]; other site 43989000628 30S ribosomal protein S1; Reviewed; Region: PRK07400 43989000629 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 43989000630 RNA binding site [nucleotide binding]; other site 43989000631 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 43989000632 RNA binding site [nucleotide binding]; other site 43989000633 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 43989000634 RNA binding site [nucleotide binding]; other site 43989000635 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 43989000636 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989000637 dimer interface [polypeptide binding]; other site 43989000638 phosphorylation site [posttranslational modification] 43989000639 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989000640 ATP binding site [chemical binding]; other site 43989000641 Mg2+ binding site [ion binding]; other site 43989000642 G-X-G motif; other site 43989000643 Response regulator receiver domain; Region: Response_reg; pfam00072 43989000644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989000645 active site 43989000646 phosphorylation site [posttranslational modification] 43989000647 intermolecular recognition site; other site 43989000648 dimerization interface [polypeptide binding]; other site 43989000649 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 43989000650 active site residue [active] 43989000651 glucose-1-dehydrogenase; Provisional; Region: PRK08936 43989000652 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 43989000653 NAD binding site [chemical binding]; other site 43989000654 homodimer interface [polypeptide binding]; other site 43989000655 active site 43989000656 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 43989000657 peripheral dimer interface [polypeptide binding]; other site 43989000658 core dimer interface [polypeptide binding]; other site 43989000659 L10 interface [polypeptide binding]; other site 43989000660 L11 interface [polypeptide binding]; other site 43989000661 putative EF-Tu interaction site [polypeptide binding]; other site 43989000662 putative EF-G interaction site [polypeptide binding]; other site 43989000663 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 43989000664 23S rRNA interface [nucleotide binding]; other site 43989000665 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 43989000666 ribosomal protein L10 leader; Rfam score 62.65 43989000667 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 43989000668 mRNA/rRNA interface [nucleotide binding]; other site 43989000669 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 43989000670 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 43989000671 23S rRNA interface [nucleotide binding]; other site 43989000672 L7/L12 interface [polypeptide binding]; other site 43989000673 putative thiostrepton binding site; other site 43989000674 L25 interface [polypeptide binding]; other site 43989000675 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 43989000676 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 43989000677 putative homodimer interface [polypeptide binding]; other site 43989000678 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 43989000679 heterodimer interface [polypeptide binding]; other site 43989000680 homodimer interface [polypeptide binding]; other site 43989000681 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 43989000682 Domain of unknown function (DUF1818); Region: DUF1818; pfam08848 43989000683 DNA-directed RNA polymerase subunit omega; Provisional; Region: ycf61; CHL00191 43989000684 argininosuccinate lyase; Provisional; Region: PRK00855 43989000685 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 43989000686 active sites [active] 43989000687 tetramer interface [polypeptide binding]; other site 43989000688 Nitrous oxide-stimulated promoter; Region: YgbA_NO; cl08119 43989000689 GAF domain; Region: GAF_3; pfam13492 43989000690 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 43989000691 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 43989000692 phosphodiesterase; Provisional; Region: PRK12704 43989000693 SGT1 protein; Region: SGT1; pfam07093 43989000694 EamA-like transporter family; Region: EamA; pfam00892 43989000695 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 43989000696 EamA-like transporter family; Region: EamA; pfam00892 43989000697 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 43989000698 Protein of unknown function, DUF393; Region: DUF393; pfam04134 43989000699 Calx-beta domain; Region: Calx-beta; cl02522 43989000700 Calx-beta domain; Region: Calx-beta; cl02522 43989000701 Calx-beta domain; Region: Calx-beta; cl02522 43989000702 Calx-beta domain; Region: Calx-beta; cl02522 43989000703 Calx-beta domain; Region: Calx-beta; cl02522 43989000704 Calx-beta domain; Region: Calx-beta; cl02522 43989000705 Calx-beta domain; Region: Calx-beta; cl02522 43989000706 Calx-beta domain; Region: Calx-beta; cl02522 43989000707 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705 43989000708 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 43989000709 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 43989000710 tocopherol phytyltransferase; Reviewed; Region: ubiA; PRK12887 43989000711 UbiA prenyltransferase family; Region: UbiA; pfam01040 43989000712 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 43989000713 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 43989000714 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 43989000715 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 43989000716 putative ADP-binding pocket [chemical binding]; other site 43989000717 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 43989000718 conserved cys residue [active] 43989000719 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 43989000720 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 43989000721 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 43989000722 TM-ABC transporter signature motif; other site 43989000723 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 43989000724 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 43989000725 dimerization interface [polypeptide binding]; other site 43989000726 DPS ferroxidase diiron center [ion binding]; other site 43989000727 ion pore; other site 43989000728 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 43989000729 Mechanosensitive ion channel; Region: MS_channel; pfam00924 43989000730 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 43989000731 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 43989000732 active site 43989000733 catalytic residues [active] 43989000734 metal binding site [ion binding]; metal-binding site 43989000735 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 43989000736 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 43989000737 transmembrane helices; other site 43989000738 TrkA-C domain; Region: TrkA_C; pfam02080 43989000739 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 43989000740 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 43989000741 TrkA-C domain; Region: TrkA_C; pfam02080 43989000742 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 43989000743 Predicted membrane protein [Function unknown]; Region: COG4709 43989000744 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 43989000745 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 43989000746 active site 43989000747 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 43989000748 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 43989000749 Protein of unknown function (DUF3252); Region: DUF3252; pfam11623 43989000750 HAS barrel domain; Region: HAS-barrel; pfam09378 43989000751 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 43989000752 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989000753 dimer interface [polypeptide binding]; other site 43989000754 phosphorylation site [posttranslational modification] 43989000755 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 43989000756 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 43989000757 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 43989000758 Active Sites [active] 43989000759 GTP-binding protein Der; Reviewed; Region: PRK00093 43989000760 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 43989000761 G1 box; other site 43989000762 GTP/Mg2+ binding site [chemical binding]; other site 43989000763 Switch I region; other site 43989000764 G2 box; other site 43989000765 Switch II region; other site 43989000766 G3 box; other site 43989000767 G4 box; other site 43989000768 G5 box; other site 43989000769 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 43989000770 G1 box; other site 43989000771 GTP/Mg2+ binding site [chemical binding]; other site 43989000772 Switch I region; other site 43989000773 G2 box; other site 43989000774 G3 box; other site 43989000775 Switch II region; other site 43989000776 G4 box; other site 43989000777 G5 box; other site 43989000778 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 43989000779 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 43989000780 Dehydroquinase class II; Region: DHquinase_II; pfam01220 43989000781 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 43989000782 trimer interface [polypeptide binding]; other site 43989000783 active site 43989000784 dimer interface [polypeptide binding]; other site 43989000785 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 43989000786 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 43989000787 protein I interface; other site 43989000788 D2 interface; other site 43989000789 protein T interface; other site 43989000790 chlorophyll binding site; other site 43989000791 beta carotene binding site; other site 43989000792 pheophytin binding site; other site 43989000793 manganese-stabilizing polypeptide interface; other site 43989000794 CP43 interface; other site 43989000795 protein L interface; other site 43989000796 oxygen evolving complex binding site; other site 43989000797 bromide binding site; other site 43989000798 quinone binding site; other site 43989000799 Fe binding site [ion binding]; other site 43989000800 core light harvesting interface; other site 43989000801 cytochrome b559 alpha subunit interface; other site 43989000802 cytochrome c-550 interface; other site 43989000803 protein J interface; other site 43989000804 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 43989000805 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 43989000806 active site 43989000807 motif I; other site 43989000808 motif II; other site 43989000809 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 43989000810 active site 43989000811 Ca binding site [ion binding]; other site 43989000812 catalytic site [active] 43989000813 Aamy_C domain; Region: Aamy_C; smart00632 43989000814 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 43989000815 dimerization interface [polypeptide binding]; other site 43989000816 putative active cleft [active] 43989000817 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 43989000818 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 43989000819 conserved cys residue [active] 43989000820 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 43989000821 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 43989000822 Walker A/P-loop; other site 43989000823 ATP binding site [chemical binding]; other site 43989000824 Q-loop/lid; other site 43989000825 ABC transporter signature motif; other site 43989000826 Walker B; other site 43989000827 D-loop; other site 43989000828 H-loop/switch region; other site 43989000829 TOBE domain; Region: TOBE_2; pfam08402 43989000830 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 43989000831 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 43989000832 homodimer interface [polypeptide binding]; other site 43989000833 oligonucleotide binding site [chemical binding]; other site 43989000834 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989000835 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 43989000836 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 43989000837 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 43989000838 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 43989000839 catalytic residue [active] 43989000840 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 43989000841 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 43989000842 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 43989000843 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 43989000844 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 43989000845 substrate binding site [chemical binding]; other site 43989000846 glutamase interaction surface [polypeptide binding]; other site 43989000847 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 43989000848 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 43989000849 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989000850 binding surface 43989000851 TPR motif; other site 43989000852 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 43989000853 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 43989000854 dimer interface [polypeptide binding]; other site 43989000855 conserved gate region; other site 43989000856 putative PBP binding loops; other site 43989000857 ABC-ATPase subunit interface; other site 43989000858 proton extrusion protein PcxA; Provisional; Region: PRK02507 43989000859 Response regulator receiver domain; Region: Response_reg; pfam00072 43989000860 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989000861 active site 43989000862 phosphorylation site [posttranslational modification] 43989000863 intermolecular recognition site; other site 43989000864 dimerization interface [polypeptide binding]; other site 43989000865 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 43989000866 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 43989000867 HSP70 interaction site [polypeptide binding]; other site 43989000868 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 43989000869 pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149 43989000870 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 43989000871 tetramer interface [polypeptide binding]; other site 43989000872 TPP-binding site [chemical binding]; other site 43989000873 heterodimer interface [polypeptide binding]; other site 43989000874 phosphorylation loop region [posttranslational modification] 43989000875 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 43989000876 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 43989000877 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 43989000878 dihydrodipicolinate synthase; Region: dapA; TIGR00674 43989000879 dimer interface [polypeptide binding]; other site 43989000880 active site 43989000881 catalytic residue [active] 43989000882 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 43989000883 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 43989000884 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 43989000885 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 43989000886 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 43989000887 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 43989000888 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989000889 dimer interface [polypeptide binding]; other site 43989000890 phosphorylation site [posttranslational modification] 43989000891 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989000892 ATP binding site [chemical binding]; other site 43989000893 Mg2+ binding site [ion binding]; other site 43989000894 G-X-G motif; other site 43989000895 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 43989000896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989000897 active site 43989000898 phosphorylation site [posttranslational modification] 43989000899 intermolecular recognition site; other site 43989000900 dimerization interface [polypeptide binding]; other site 43989000901 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 43989000902 DNA binding site [nucleotide binding] 43989000903 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 43989000904 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989000905 ATP binding site [chemical binding]; other site 43989000906 Mg2+ binding site [ion binding]; other site 43989000907 G-X-G motif; other site 43989000908 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 43989000909 ATP binding site [chemical binding]; other site 43989000910 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 43989000911 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 43989000912 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 43989000913 C-terminal domain interface [polypeptide binding]; other site 43989000914 GSH binding site (G-site) [chemical binding]; other site 43989000915 dimer interface [polypeptide binding]; other site 43989000916 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 43989000917 dimer interface [polypeptide binding]; other site 43989000918 N-terminal domain interface [polypeptide binding]; other site 43989000919 substrate binding pocket (H-site) [chemical binding]; other site 43989000920 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 43989000921 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 43989000922 Walker A/P-loop; other site 43989000923 ATP binding site [chemical binding]; other site 43989000924 Q-loop/lid; other site 43989000925 ABC transporter signature motif; other site 43989000926 Walker B; other site 43989000927 D-loop; other site 43989000928 H-loop/switch region; other site 43989000929 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 43989000930 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 43989000931 Walker A/P-loop; other site 43989000932 ATP binding site [chemical binding]; other site 43989000933 Q-loop/lid; other site 43989000934 ABC transporter signature motif; other site 43989000935 Walker B; other site 43989000936 D-loop; other site 43989000937 H-loop/switch region; other site 43989000938 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 43989000939 NMT1-like family; Region: NMT1_2; pfam13379 43989000940 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 43989000941 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 43989000942 dimer interface [polypeptide binding]; other site 43989000943 conserved gate region; other site 43989000944 ABC-ATPase subunit interface; other site 43989000945 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 43989000946 NMT1-like family; Region: NMT1_2; pfam13379 43989000947 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 43989000948 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 43989000949 hydroxyglutarate oxidase; Provisional; Region: PRK11728 43989000950 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 43989000951 ThiS interaction site; other site 43989000952 putative active site [active] 43989000953 tetramer interface [polypeptide binding]; other site 43989000954 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 43989000955 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 43989000956 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 43989000957 putative active site [active] 43989000958 oxyanion strand; other site 43989000959 catalytic triad [active] 43989000960 radical SAM/SPASM domain protein, GRRM system; Region: rSAM_GlyRichRpt; TIGR04261 43989000961 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 43989000962 FeS/SAM binding site; other site 43989000963 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 43989000964 rSAM-associated Gly-rich repeat protein; Region: Cyano_gly_rpt; TIGR04260 43989000965 rSAM-associated Gly-rich repeat protein; Region: Cyano_gly_rpt; TIGR04260 43989000966 extracellular substrate-binding orphan protein, GRRM family; Region: orph_peri_GRRM; TIGR04262 43989000967 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 43989000968 substrate binding pocket [chemical binding]; other site 43989000969 membrane-bound complex binding site; other site 43989000970 hinge residues; other site 43989000971 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 43989000972 oligomerization interface [polypeptide binding]; other site 43989000973 active site 43989000974 metal binding site [ion binding]; metal-binding site 43989000975 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 43989000976 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989000977 S-adenosylmethionine binding site [chemical binding]; other site 43989000978 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 43989000979 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 43989000980 active site 43989000981 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 43989000982 ABC1 family; Region: ABC1; cl17513 43989000983 S-layer homology domain; Region: SLH; pfam00395 43989000984 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 43989000985 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 43989000986 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 43989000987 putative NAD(P) binding site [chemical binding]; other site 43989000988 active site 43989000989 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 43989000990 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 43989000991 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 43989000992 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 43989000993 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 43989000994 Surface antigen; Region: Bac_surface_Ag; pfam01103 43989000995 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 43989000996 Protein of unknown function DUF58; Region: DUF58; pfam01882 43989000997 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 43989000998 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 43989000999 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 43989001000 generic binding surface II; other site 43989001001 ssDNA binding site; other site 43989001002 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 43989001003 ATP binding site [chemical binding]; other site 43989001004 putative Mg++ binding site [ion binding]; other site 43989001005 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 43989001006 nucleotide binding region [chemical binding]; other site 43989001007 ATP-binding site [chemical binding]; other site 43989001008 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 43989001009 active site 43989001010 catalytic residues [active] 43989001011 Sodium Bile acid symporter family; Region: SBF; cl17470 43989001012 NurA domain; Region: NurA; pfam09376 43989001013 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 43989001014 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 43989001015 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 43989001016 ScpA/B protein; Region: ScpA_ScpB; pfam02616 43989001017 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 43989001018 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 43989001019 active site 43989001020 Substrate binding site; other site 43989001021 Mg++ binding site; other site 43989001022 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 43989001023 putative trimer interface [polypeptide binding]; other site 43989001024 putative CoA binding site [chemical binding]; other site 43989001025 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 43989001026 conserved hypothetical protein; Region: TIGR03492 43989001027 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 43989001028 ligand binding site; other site 43989001029 tetramer interface; other site 43989001030 Uncharacterized conserved protein [Function unknown]; Region: COG0432 43989001031 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 43989001032 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 43989001033 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 43989001034 HflK protein; Region: hflK; TIGR01933 43989001035 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 43989001036 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 43989001037 Walker A/P-loop; other site 43989001038 ATP binding site [chemical binding]; other site 43989001039 Q-loop/lid; other site 43989001040 ABC transporter signature motif; other site 43989001041 Walker B; other site 43989001042 D-loop; other site 43989001043 H-loop/switch region; other site 43989001044 Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910 43989001045 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 43989001046 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 43989001047 Predicted transcriptional regulator [Transcription]; Region: COG2378 43989001048 WYL domain; Region: WYL; pfam13280 43989001049 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 43989001050 CRISPR-associated protein; Region: DUF3692; pfam12469 43989001051 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 43989001052 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989001053 putative active site [active] 43989001054 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 43989001055 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 43989001056 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873 43989001057 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440 43989001058 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 43989001059 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 43989001060 Transposase; Region: HTH_Tnp_1; cl17663 43989001061 Transposase; Region: DDE_Tnp_ISL3; pfam01610 43989001062 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 43989001063 NMT1-like family; Region: NMT1_2; pfam13379 43989001064 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 43989001065 AAA domain; Region: AAA_23; pfam13476 43989001066 Walker A/P-loop; other site 43989001067 ATP binding site [chemical binding]; other site 43989001068 Q-loop/lid; other site 43989001069 exonuclease SbcC; Region: sbcc; TIGR00618 43989001070 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 43989001071 ABC transporter signature motif; other site 43989001072 Walker B; other site 43989001073 D-loop; other site 43989001074 H-loop/switch region; other site 43989001075 Uncharacterized conserved protein [Function unknown]; Region: COG3791 43989001076 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 43989001077 nucleotide binding site/active site [active] 43989001078 HIT family signature motif; other site 43989001079 catalytic residue [active] 43989001080 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 43989001081 ABC1 family; Region: ABC1; cl17513 43989001082 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 43989001083 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 43989001084 Walker A/P-loop; other site 43989001085 ATP binding site [chemical binding]; other site 43989001086 Q-loop/lid; other site 43989001087 ABC transporter signature motif; other site 43989001088 Walker B; other site 43989001089 D-loop; other site 43989001090 H-loop/switch region; other site 43989001091 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 43989001092 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 43989001093 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 43989001094 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 43989001095 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 43989001096 protein binding site [polypeptide binding]; other site 43989001097 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 43989001098 putative efflux protein, MATE family; Region: matE; TIGR00797 43989001099 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 43989001100 CHASE2 domain; Region: CHASE2; pfam05226 43989001101 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 43989001102 metal binding site [ion binding]; metal-binding site 43989001103 active site 43989001104 I-site; other site 43989001105 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 43989001106 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 43989001107 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 43989001108 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 43989001109 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 43989001110 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989001111 S-adenosylmethionine binding site [chemical binding]; other site 43989001112 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 43989001113 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 43989001114 Ligand binding site; other site 43989001115 Putative Catalytic site; other site 43989001116 DXD motif; other site 43989001117 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 43989001118 Methyltransferase domain; Region: Methyltransf_23; pfam13489 43989001119 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989001120 S-adenosylmethionine binding site [chemical binding]; other site 43989001121 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 43989001122 Domain of unknown function DUF29; Region: DUF29; pfam01724 43989001123 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 43989001124 dimerization interface [polypeptide binding]; other site 43989001125 active site 43989001126 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 43989001127 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 43989001128 trimer interface [polypeptide binding]; other site 43989001129 active site 43989001130 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 43989001131 trimer interface [polypeptide binding]; other site 43989001132 active site 43989001133 PIN domain; Region: PIN_3; pfam13470 43989001134 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 43989001135 catalytic motif [active] 43989001136 Zn binding site [ion binding]; other site 43989001137 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 43989001138 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 43989001139 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 43989001140 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 43989001141 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 43989001142 motif II; other site 43989001143 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 43989001144 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 43989001145 TrkA-N domain; Region: TrkA_N; pfam02254 43989001146 TrkA-C domain; Region: TrkA_C; pfam02080 43989001147 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 43989001148 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 43989001149 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 43989001150 ATP cone domain; Region: ATP-cone; pfam03477 43989001151 photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875 43989001152 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 43989001153 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 43989001154 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 43989001155 active site 43989001156 homodimer interface [polypeptide binding]; other site 43989001157 catalytic site [active] 43989001158 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 43989001159 nitrilase; Region: PLN02798 43989001160 putative active site [active] 43989001161 catalytic triad [active] 43989001162 dimer interface [polypeptide binding]; other site 43989001163 fumarate hydratase; Reviewed; Region: fumC; PRK00485 43989001164 Class II fumarases; Region: Fumarase_classII; cd01362 43989001165 active site 43989001166 tetramer interface [polypeptide binding]; other site 43989001167 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 43989001168 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 43989001169 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346 43989001170 putative ligand binding site [chemical binding]; other site 43989001171 photosystem I reaction center subunit X; Reviewed; Region: PRK13214 43989001172 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 43989001173 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 43989001174 hinge; other site 43989001175 active site 43989001176 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 43989001177 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 43989001178 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 43989001179 Mechanosensitive ion channel; Region: MS_channel; pfam00924 43989001180 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 43989001181 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 43989001182 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 43989001183 putative active site [active] 43989001184 putative substrate binding site [chemical binding]; other site 43989001185 putative cosubstrate binding site; other site 43989001186 catalytic site [active] 43989001187 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 43989001188 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 43989001189 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 43989001190 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 43989001191 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 43989001192 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 43989001193 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 43989001194 active site 43989001195 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 43989001196 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 43989001197 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 43989001198 putative active site [active] 43989001199 putative NTP binding site [chemical binding]; other site 43989001200 putative nucleic acid binding site [nucleotide binding]; other site 43989001201 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 43989001202 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 43989001203 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 43989001204 active site 43989001205 putative acyl transferase; Provisional; Region: PRK10502 43989001206 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 43989001207 putative trimer interface [polypeptide binding]; other site 43989001208 putative active site [active] 43989001209 putative substrate binding site [chemical binding]; other site 43989001210 putative CoA binding site [chemical binding]; other site 43989001211 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 43989001212 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 43989001213 putative metal binding site; other site 43989001214 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 43989001215 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 43989001216 HlyD family secretion protein; Region: HlyD_3; pfam13437 43989001217 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 43989001218 Protein export membrane protein; Region: SecD_SecF; cl14618 43989001219 YppG-like protein; Region: YppG; pfam14179 43989001220 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 43989001221 Domain of unknown function (DUF814); Region: DUF814; pfam05670 43989001222 Pleckstrin homology-like domain; Region: PH-like; cl17171 43989001223 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 43989001224 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 43989001225 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 43989001226 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 43989001227 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 43989001228 Walker A motif; other site 43989001229 ATP binding site [chemical binding]; other site 43989001230 Walker B motif; other site 43989001231 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 43989001232 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 43989001233 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 43989001234 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 43989001235 Walker A motif; other site 43989001236 ATP binding site [chemical binding]; other site 43989001237 Walker B motif; other site 43989001238 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 43989001239 circadian clock protein KaiC; Reviewed; Region: PRK09302 43989001240 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 43989001241 Walker A motif; other site 43989001242 ATP binding site [chemical binding]; other site 43989001243 Walker B motif; other site 43989001244 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 43989001245 ATP binding site [chemical binding]; other site 43989001246 Walker B motif; other site 43989001247 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 43989001248 tetramer interface [polypeptide binding]; other site 43989001249 dimer interface [polypeptide binding]; other site 43989001250 KaiA domain; Region: KaiA; pfam07688 43989001251 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 43989001252 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 43989001253 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 43989001254 active site 43989001255 substrate binding site [chemical binding]; other site 43989001256 cosubstrate binding site; other site 43989001257 catalytic site [active] 43989001258 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 43989001259 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 43989001260 [2Fe-2S] cluster binding site [ion binding]; other site 43989001261 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 43989001262 Transcriptional regulators [Transcription]; Region: MarR; COG1846 43989001263 Protein of unknown function (DUF760); Region: DUF760; pfam05542 43989001264 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 43989001265 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 43989001266 Walker A motif; other site 43989001267 ATP binding site [chemical binding]; other site 43989001268 Walker B motif; other site 43989001269 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 43989001270 tetramer interface [polypeptide binding]; other site 43989001271 dimer interface [polypeptide binding]; other site 43989001272 Transmembrane proteins 14C; Region: Tmemb_14; pfam03647 43989001273 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 43989001274 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 43989001275 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 43989001276 Uncharacterized conserved protein [Function unknown]; Region: COG1262 43989001277 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 43989001278 Bacitracin resistance protein BacA; Region: BacA; pfam02673 43989001279 Thf1-like protein; Reviewed; Region: PRK13266 43989001280 photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060 43989001281 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 43989001282 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989001283 binding surface 43989001284 TPR motif; other site 43989001285 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 43989001286 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 43989001287 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 43989001288 dimer interface [polypeptide binding]; other site 43989001289 putative CheW interface [polypeptide binding]; other site 43989001290 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 43989001291 Response regulator receiver domain; Region: Response_reg; pfam00072 43989001292 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989001293 active site 43989001294 phosphorylation site [posttranslational modification] 43989001295 intermolecular recognition site; other site 43989001296 dimerization interface [polypeptide binding]; other site 43989001297 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 43989001298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989001299 active site 43989001300 phosphorylation site [posttranslational modification] 43989001301 intermolecular recognition site; other site 43989001302 dimerization interface [polypeptide binding]; other site 43989001303 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 43989001304 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 43989001305 Uncharacterized conserved protein [Function unknown]; Region: COG3791 43989001306 Rrf2 family protein; Region: rrf2_super; TIGR00738 43989001307 Transcriptional regulator; Region: Rrf2; pfam02082 43989001308 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 43989001309 Protein of unknown function (DUF3143); Region: DUF3143; pfam11341 43989001310 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 43989001311 HSP70 interaction site [polypeptide binding]; other site 43989001312 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 43989001313 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 43989001314 Catalytic NodB homology domain of uncharacterized chitin deacetylases and hypothetical proteins; Region: CE4_NodB_like_2; cd10958 43989001315 putative active site [active] 43989001316 NodB motif; other site 43989001317 Methyltransferase domain; Region: Methyltransf_31; pfam13847 43989001318 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989001319 S-adenosylmethionine binding site [chemical binding]; other site 43989001320 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 43989001321 enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370 43989001322 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 43989001323 NAD binding site [chemical binding]; other site 43989001324 homotetramer interface [polypeptide binding]; other site 43989001325 homodimer interface [polypeptide binding]; other site 43989001326 substrate binding site [chemical binding]; other site 43989001327 active site 43989001328 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 43989001329 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 43989001330 ligand binding site [chemical binding]; other site 43989001331 flexible hinge region; other site 43989001332 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 43989001333 putative switch regulator; other site 43989001334 non-specific DNA interactions [nucleotide binding]; other site 43989001335 DNA binding site [nucleotide binding] 43989001336 sequence specific DNA binding site [nucleotide binding]; other site 43989001337 putative cAMP binding site [chemical binding]; other site 43989001338 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 43989001339 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 43989001340 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 43989001341 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 43989001342 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 43989001343 Domain of unknown function (DUF697); Region: DUF697; pfam05128 43989001344 H+ Antiporter protein; Region: 2A0121; TIGR00900 43989001345 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 43989001346 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 43989001347 anti sigma factor interaction site; other site 43989001348 regulatory phosphorylation site [posttranslational modification]; other site 43989001349 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 43989001350 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 43989001351 FeS/SAM binding site; other site 43989001352 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 43989001353 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 43989001354 XisI protein; Region: XisI; pfam08869 43989001355 Leucine rich repeat; Region: LRR_8; pfam13855 43989001356 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 43989001357 Substrate binding site [chemical binding]; other site 43989001358 Leucine rich repeat; Region: LRR_8; pfam13855 43989001359 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 43989001360 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 43989001361 putative C-terminal domain interface [polypeptide binding]; other site 43989001362 putative GSH binding site (G-site) [chemical binding]; other site 43989001363 putative dimer interface [polypeptide binding]; other site 43989001364 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 43989001365 N-terminal domain interface [polypeptide binding]; other site 43989001366 dimer interface [polypeptide binding]; other site 43989001367 substrate binding pocket (H-site) [chemical binding]; other site 43989001368 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 43989001369 homotrimer interaction site [polypeptide binding]; other site 43989001370 zinc binding site [ion binding]; other site 43989001371 CDP-binding sites; other site 43989001372 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 43989001373 dimer interface [polypeptide binding]; other site 43989001374 [2Fe-2S] cluster binding site [ion binding]; other site 43989001375 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 43989001376 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 43989001377 dimerization interface [polypeptide binding]; other site 43989001378 DPS ferroxidase diiron center [ion binding]; other site 43989001379 ion pore; other site 43989001380 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 43989001381 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989001382 binding surface 43989001383 TPR motif; other site 43989001384 TPR repeat; Region: TPR_11; pfam13414 43989001385 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989001386 binding surface 43989001387 TPR repeat; Region: TPR_11; pfam13414 43989001388 TPR motif; other site 43989001389 Tetratricopeptide repeat; Region: TPR_16; pfam13432 43989001390 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 43989001391 metal-binding site [ion binding] 43989001392 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 43989001393 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 43989001394 putative metal binding site [ion binding]; other site 43989001395 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 43989001396 DHH family; Region: DHH; pfam01368 43989001397 DHHA1 domain; Region: DHHA1; pfam02272 43989001398 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 43989001399 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 43989001400 GTP/Mg2+ binding site [chemical binding]; other site 43989001401 G4 box; other site 43989001402 G5 box; other site 43989001403 G1 box; other site 43989001404 Switch I region; other site 43989001405 G2 box; other site 43989001406 G3 box; other site 43989001407 Switch II region; other site 43989001408 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 43989001409 GUN4-like; Region: GUN4; pfam05419 43989001410 Mechanosensitive ion channel; Region: MS_channel; pfam00924 43989001411 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 43989001412 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 43989001413 ligand binding site [chemical binding]; other site 43989001414 flexible hinge region; other site 43989001415 glutathione synthetase; Provisional; Region: PRK05246 43989001416 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 43989001417 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 43989001418 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 43989001419 GSH binding site [chemical binding]; other site 43989001420 catalytic residues [active] 43989001421 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989001422 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 43989001423 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989001424 Tetratricopeptide repeat; Region: TPR_1; pfam00515 43989001425 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 43989001426 active site 43989001427 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 43989001428 active site 43989001429 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 43989001430 Protein of unknown function (DUF1036); Region: DUF1036; cl02296 43989001431 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 43989001432 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 43989001433 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 43989001434 Walker A/P-loop; other site 43989001435 ATP binding site [chemical binding]; other site 43989001436 Q-loop/lid; other site 43989001437 ABC transporter signature motif; other site 43989001438 Walker B; other site 43989001439 D-loop; other site 43989001440 H-loop/switch region; other site 43989001441 cytochrome c biogenesis protein; Region: ccsA; CHL00045 43989001442 Bacterial SH3 domain; Region: SH3_3; cl17532 43989001443 bifunctional orotidine 5'-phosphate decarboxylase/orotate phosphoribosyltransferase protein; Validated; Region: PRK05500 43989001444 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 43989001445 active site 43989001446 dimer interface [polypeptide binding]; other site 43989001447 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 43989001448 active site 43989001449 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 43989001450 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 43989001451 Walker A motif; other site 43989001452 ATP binding site [chemical binding]; other site 43989001453 Walker B motif; other site 43989001454 arginine finger; other site 43989001455 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 43989001456 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 43989001457 chain length determinant protein tyrosine kinase EpsG; Region: EpsG; TIGR03029 43989001458 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 43989001459 active site 43989001460 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 43989001461 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 43989001462 active site 43989001463 substrate-binding site [chemical binding]; other site 43989001464 metal-binding site [ion binding] 43989001465 ATP binding site [chemical binding]; other site 43989001466 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 43989001467 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 43989001468 active site 43989001469 HIGH motif; other site 43989001470 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 43989001471 KMSKS motif; other site 43989001472 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 43989001473 tRNA binding surface [nucleotide binding]; other site 43989001474 anticodon binding site; other site 43989001475 homoserine kinase; Provisional; Region: PRK01212 43989001476 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 43989001477 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 43989001478 Methyltransferase domain; Region: Methyltransf_24; pfam13578 43989001479 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 43989001480 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 43989001481 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 43989001482 Methyltransferase domain; Region: Methyltransf_23; pfam13489 43989001483 Methyltransferase domain; Region: Methyltransf_12; pfam08242 43989001484 S-adenosylmethionine binding site [chemical binding]; other site 43989001485 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989001486 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 43989001487 putative glycosyl transferase; Provisional; Region: PRK10125 43989001488 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 43989001489 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 43989001490 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 43989001491 metal-binding site 43989001492 Methyltransferase domain; Region: Methyltransf_23; pfam13489 43989001493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989001494 S-adenosylmethionine binding site [chemical binding]; other site 43989001495 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 43989001496 Ligand binding site; other site 43989001497 Putative Catalytic site; other site 43989001498 DXD motif; other site 43989001499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989001500 S-adenosylmethionine binding site [chemical binding]; other site 43989001501 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 43989001502 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 43989001503 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 43989001504 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 43989001505 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 43989001506 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 43989001507 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 43989001508 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 43989001509 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 43989001510 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 43989001511 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 43989001512 active site 43989001513 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 43989001514 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 43989001515 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 43989001516 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 43989001517 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 43989001518 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 43989001519 putative active site [active] 43989001520 putative metal binding residues [ion binding]; other site 43989001521 signature motif; other site 43989001522 putative dimer interface [polypeptide binding]; other site 43989001523 putative phosphate binding site [ion binding]; other site 43989001524 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 43989001525 dimer interface [polypeptide binding]; other site 43989001526 [2Fe-2S] cluster binding site [ion binding]; other site 43989001527 DGQHR domain; Region: DGQHR; TIGR03187 43989001528 DNA-sulfur modification-associated; Region: DndB; cl17621 43989001529 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 43989001530 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 43989001531 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 43989001532 active site 43989001533 SAM binding site [chemical binding]; other site 43989001534 homodimer interface [polypeptide binding]; other site 43989001535 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989001536 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 43989001537 putative active site [active] 43989001538 heme pocket [chemical binding]; other site 43989001539 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989001540 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 43989001541 putative active site [active] 43989001542 heme pocket [chemical binding]; other site 43989001543 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 43989001544 putative active site [active] 43989001545 heme pocket [chemical binding]; other site 43989001546 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 43989001547 16S rRNA methyltransferase B; Provisional; Region: PRK14901 43989001548 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 43989001549 putative RNA binding site [nucleotide binding]; other site 43989001550 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989001551 S-adenosylmethionine binding site [chemical binding]; other site 43989001552 tellurium resistance terB-like protein; Region: terB_like; cd07177 43989001553 metal binding site [ion binding]; metal-binding site 43989001554 Uncharacterized conserved protein [Function unknown]; Region: COG1432 43989001555 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 43989001556 putative metal binding site [ion binding]; other site 43989001557 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 43989001558 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 43989001559 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 43989001560 Coenzyme A binding pocket [chemical binding]; other site 43989001561 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 43989001562 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 43989001563 oligomer interface [polypeptide binding]; other site 43989001564 metal binding site [ion binding]; metal-binding site 43989001565 metal binding site [ion binding]; metal-binding site 43989001566 Cl binding site [ion binding]; other site 43989001567 aspartate ring; other site 43989001568 basic sphincter; other site 43989001569 putative hydrophobic gate; other site 43989001570 periplasmic entrance; other site 43989001571 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033 43989001572 ArsC family; Region: ArsC; pfam03960 43989001573 putative catalytic residues [active] 43989001574 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 43989001575 dimer interface [polypeptide binding]; other site 43989001576 [2Fe-2S] cluster binding site [ion binding]; other site 43989001577 NifT/FixU protein; Region: NifT; pfam06988 43989001578 NifZ domain; Region: NifZ; pfam04319 43989001579 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 43989001580 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 43989001581 active site 43989001582 catalytic residues [active] 43989001583 metal binding site [ion binding]; metal-binding site 43989001584 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 43989001585 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 43989001586 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 43989001587 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 43989001588 trimer interface [polypeptide binding]; other site 43989001589 active site 43989001590 substrate binding site [chemical binding]; other site 43989001591 CoA binding site [chemical binding]; other site 43989001592 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 43989001593 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 43989001594 FeS/SAM binding site; other site 43989001595 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 43989001596 4Fe-4S binding domain; Region: Fer4; cl02805 43989001597 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 43989001598 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 43989001599 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 43989001600 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 43989001601 catalytic residue [active] 43989001602 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 43989001603 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 43989001604 trimerization site [polypeptide binding]; other site 43989001605 active site 43989001606 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 43989001607 NifU-like domain; Region: NifU; pfam01106 43989001608 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 43989001609 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 43989001610 Nucleotide-binding sites [chemical binding]; other site 43989001611 Walker A motif; other site 43989001612 Switch I region of nucleotide binding site; other site 43989001613 Fe4S4 binding sites [ion binding]; other site 43989001614 Switch II region of nucleotide binding site; other site 43989001615 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 43989001616 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 43989001617 MoFe protein alpha/beta subunit interactions; other site 43989001618 Alpha subunit P cluster binding residues; other site 43989001619 FeMoco binding residues [chemical binding]; other site 43989001620 MoFe protein alpha subunit/Fe protein contacts; other site 43989001621 MoFe protein dimer/ dimer interactions; other site 43989001622 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 43989001623 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 43989001624 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 43989001625 MoFe protein beta/alpha subunit interactions; other site 43989001626 Beta subunit P cluster binding residues; other site 43989001627 MoFe protein beta subunit/Fe protein contacts; other site 43989001628 MoFe protein dimer/ dimer interactions; other site 43989001629 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 43989001630 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 43989001631 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968 43989001632 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 43989001633 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 43989001634 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 43989001635 Protein of unknown function, DUF269; Region: DUF269; pfam03270 43989001636 Rop-like; Region: Rop-like; pfam05082 43989001637 nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK14102 43989001638 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 43989001639 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 43989001640 ATP binding site [chemical binding]; other site 43989001641 substrate interface [chemical binding]; other site 43989001642 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 43989001643 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 43989001644 catalytic loop [active] 43989001645 iron binding site [ion binding]; other site 43989001646 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 43989001647 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 43989001648 G1 box; other site 43989001649 GTP/Mg2+ binding site [chemical binding]; other site 43989001650 Switch I region; other site 43989001651 G2 box; other site 43989001652 G3 box; other site 43989001653 Switch II region; other site 43989001654 G4 box; other site 43989001655 G5 box; other site 43989001656 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 43989001657 Nucleoside recognition; Region: Gate; pfam07670 43989001658 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 43989001659 Nucleoside recognition; Region: Gate; pfam07670 43989001660 FeoA domain; Region: FeoA; pfam04023 43989001661 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 43989001662 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 43989001663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 43989001664 putative PBP binding loops; other site 43989001665 dimer interface [polypeptide binding]; other site 43989001666 ABC-ATPase subunit interface; other site 43989001667 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 43989001668 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 43989001669 Walker A/P-loop; other site 43989001670 ATP binding site [chemical binding]; other site 43989001671 Q-loop/lid; other site 43989001672 ABC transporter signature motif; other site 43989001673 Walker B; other site 43989001674 D-loop; other site 43989001675 H-loop/switch region; other site 43989001676 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 43989001677 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 43989001678 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 43989001679 oligomeric interface; other site 43989001680 putative active site [active] 43989001681 homodimer interface [polypeptide binding]; other site 43989001682 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 43989001683 oligomeric interface; other site 43989001684 putative active site [active] 43989001685 homodimer interface [polypeptide binding]; other site 43989001686 Protein of unknown function (DUF433); Region: DUF433; pfam04255 43989001687 comF family protein; Region: comF; TIGR00201 43989001688 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 43989001689 active site 43989001690 TPR repeat; Region: TPR_11; pfam13414 43989001691 TPR repeat; Region: TPR_11; pfam13414 43989001692 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989001693 binding surface 43989001694 TPR motif; other site 43989001695 TPR repeat; Region: TPR_11; pfam13414 43989001696 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989001697 binding surface 43989001698 TPR motif; other site 43989001699 Tetratricopeptide repeat; Region: TPR_12; pfam13424 43989001700 Cytochrome c; Region: Cytochrom_C; cl11414 43989001701 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 43989001702 plastocyanin; Provisional; Region: PRK02710 43989001703 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 43989001704 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 43989001705 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 43989001706 active site 43989001707 intersubunit interface [polypeptide binding]; other site 43989001708 catalytic residue [active] 43989001709 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 43989001710 Peptidase S8 family domain, uncharacterized subfamily 12; Region: Peptidases_S8_12; cd07480 43989001711 active site 43989001712 catalytic triad [active] 43989001713 gamma-glutamyl kinase; Provisional; Region: PRK05429 43989001714 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 43989001715 nucleotide binding site [chemical binding]; other site 43989001716 homotetrameric interface [polypeptide binding]; other site 43989001717 putative phosphate binding site [ion binding]; other site 43989001718 putative allosteric binding site; other site 43989001719 PUA domain; Region: PUA; pfam01472 43989001720 glucokinase, proteobacterial type; Region: glk; TIGR00749 43989001721 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 43989001722 nucleotide binding site [chemical binding]; other site 43989001723 Mrr N-terminal domain; Region: Mrr_N; pfam14338 43989001724 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 43989001725 Restriction endonuclease; Region: Mrr_cat; pfam04471 43989001726 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 43989001727 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 43989001728 Protein of unknown function (DUF3747); Region: DUF3747; pfam12565 43989001729 S-layer homology domain; Region: SLH; pfam00395 43989001730 S-layer homology domain; Region: SLH; pfam00395 43989001731 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 43989001732 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 43989001733 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 43989001734 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 43989001735 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 43989001736 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 43989001737 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 43989001738 DNA binding residues [nucleotide binding] 43989001739 light-harvesting-like protein 3; Provisional; Region: PLN00014 43989001740 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 43989001741 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 43989001742 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 43989001743 NAD(P)H-quinone oxidoreductase subunit M; Validated; Region: PRK07363 43989001744 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 43989001745 CO2 hydration protein (ChpXY); Region: ChpXY; cl10905 43989001746 phosphoglucomutase; Region: PLN02307 43989001747 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 43989001748 substrate binding site [chemical binding]; other site 43989001749 dimer interface [polypeptide binding]; other site 43989001750 active site 43989001751 metal binding site [ion binding]; metal-binding site 43989001752 Gram-negative bacterial tonB protein; Region: TonB; cl10048 43989001753 magnesium chelatase subunit H; Provisional; Region: PLN03241 43989001754 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 43989001755 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 43989001756 PIN domain; Region: PIN_3; pfam13470 43989001757 magnesium chelatase subunit H; Provisional; Region: PLN03241 43989001758 Methyltransferase domain; Region: Methyltransf_23; pfam13489 43989001759 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989001760 S-adenosylmethionine binding site [chemical binding]; other site 43989001761 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 43989001762 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 43989001763 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989001764 putative active site [active] 43989001765 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 43989001766 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 43989001767 NAD binding site [chemical binding]; other site 43989001768 substrate binding site [chemical binding]; other site 43989001769 homodimer interface [polypeptide binding]; other site 43989001770 active site 43989001771 Domain of unknown function DUF29; Region: DUF29; pfam01724 43989001772 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 43989001773 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 43989001774 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 43989001775 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 43989001776 RNase E interface [polypeptide binding]; other site 43989001777 trimer interface [polypeptide binding]; other site 43989001778 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 43989001779 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 43989001780 RNase E interface [polypeptide binding]; other site 43989001781 trimer interface [polypeptide binding]; other site 43989001782 active site 43989001783 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 43989001784 putative nucleic acid binding region [nucleotide binding]; other site 43989001785 G-X-X-G motif; other site 43989001786 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 43989001787 RNA binding site [nucleotide binding]; other site 43989001788 domain interface; other site 43989001789 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 43989001790 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 43989001791 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 43989001792 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989001793 putative active site [active] 43989001794 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 43989001795 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 43989001796 Tetratricopeptide repeat; Region: TPR_12; pfam13424 43989001797 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 43989001798 acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100 43989001799 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 43989001800 putative valine binding site [chemical binding]; other site 43989001801 dimer interface [polypeptide binding]; other site 43989001802 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 43989001803 CP12 domain; Region: CP12; pfam02672 43989001804 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 43989001805 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 43989001806 active site 43989001807 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 43989001808 protein binding site [polypeptide binding]; other site 43989001809 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 43989001810 putative substrate binding region [chemical binding]; other site 43989001811 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989001812 putative active site [active] 43989001813 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989001814 S-adenosylmethionine binding site [chemical binding]; other site 43989001815 Domain of unknown function DUF29; Region: DUF29; pfam01724 43989001816 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 43989001817 Transposase; Region: HTH_Tnp_1; cl17663 43989001818 Transposase; Region: DDE_Tnp_ISL3; pfam01610 43989001819 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 43989001820 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 43989001821 Family description; Region: UvrD_C_2; pfam13538 43989001822 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 43989001823 protein I interface; other site 43989001824 D2 interface; other site 43989001825 protein T interface; other site 43989001826 chlorophyll binding site; other site 43989001827 beta carotene binding site; other site 43989001828 pheophytin binding site; other site 43989001829 manganese-stabilizing polypeptide interface; other site 43989001830 CP43 interface; other site 43989001831 protein L interface; other site 43989001832 oxygen evolving complex binding site; other site 43989001833 bromide binding site; other site 43989001834 quinone binding site; other site 43989001835 Fe binding site [ion binding]; other site 43989001836 core light harvesting interface; other site 43989001837 cytochrome b559 alpha subunit interface; other site 43989001838 cytochrome c-550 interface; other site 43989001839 protein J interface; other site 43989001840 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 43989001841 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 43989001842 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 43989001843 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 43989001844 putative active site [active] 43989001845 putative NTP binding site [chemical binding]; other site 43989001846 putative nucleic acid binding site [nucleotide binding]; other site 43989001847 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 43989001848 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 43989001849 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 43989001850 active site 43989001851 DDE superfamily endonuclease; Region: DDE_4; pfam13359 43989001852 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 43989001853 Clp protease; Region: CLP_protease; pfam00574 43989001854 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 43989001855 oligomer interface [polypeptide binding]; other site 43989001856 active site residues [active] 43989001857 Domain of unknown function DUF21; Region: DUF21; pfam01595 43989001858 FOG: CBS domain [General function prediction only]; Region: COG0517 43989001859 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 43989001860 RNA polymerase sigma factor; Validated; Region: PRK05949 43989001861 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 43989001862 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 43989001863 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 43989001864 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 43989001865 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 43989001866 DNA binding residues [nucleotide binding] 43989001867 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 43989001868 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 43989001869 Walker A/P-loop; other site 43989001870 ATP binding site [chemical binding]; other site 43989001871 Q-loop/lid; other site 43989001872 ABC transporter signature motif; other site 43989001873 Walker B; other site 43989001874 D-loop; other site 43989001875 H-loop/switch region; other site 43989001876 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 43989001877 Protein of unknown function (DUF1640); Region: DUF1640; pfam07798 43989001878 HlyD family secretion protein; Region: HlyD_3; pfam13437 43989001879 DevC protein; Region: devC; TIGR01185 43989001880 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 43989001881 FtsX-like permease family; Region: FtsX; pfam02687 43989001882 Predicted integral membrane protein [Function unknown]; Region: COG0762 43989001883 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 43989001884 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766 43989001885 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 43989001886 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 43989001887 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 43989001888 catalytic loop [active] 43989001889 iron binding site [ion binding]; other site 43989001890 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 43989001891 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 43989001892 Walker A/P-loop; other site 43989001893 ATP binding site [chemical binding]; other site 43989001894 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 43989001895 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989001896 dimer interface [polypeptide binding]; other site 43989001897 phosphorylation site [posttranslational modification] 43989001898 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989001899 ATP binding site [chemical binding]; other site 43989001900 Mg2+ binding site [ion binding]; other site 43989001901 G-X-G motif; other site 43989001902 Response regulator receiver domain; Region: Response_reg; pfam00072 43989001903 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989001904 active site 43989001905 phosphorylation site [posttranslational modification] 43989001906 intermolecular recognition site; other site 43989001907 dimerization interface [polypeptide binding]; other site 43989001908 Response regulator receiver domain; Region: Response_reg; pfam00072 43989001909 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989001910 active site 43989001911 phosphorylation site [posttranslational modification] 43989001912 intermolecular recognition site; other site 43989001913 dimerization interface [polypeptide binding]; other site 43989001914 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 43989001915 putative binding surface; other site 43989001916 active site 43989001917 Response regulator receiver domain; Region: Response_reg; pfam00072 43989001918 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989001919 active site 43989001920 phosphorylation site [posttranslational modification] 43989001921 intermolecular recognition site; other site 43989001922 dimerization interface [polypeptide binding]; other site 43989001923 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 43989001924 GAF domain; Region: GAF; cl17456 43989001925 HEAT repeats; Region: HEAT_2; pfam13646 43989001926 HEAT repeats; Region: HEAT_2; pfam13646 43989001927 HEAT repeats; Region: HEAT_2; pfam13646 43989001928 photosystem II 44 kDa protein; Region: psbC; CHL00035 43989001929 photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153 43989001930 D2 subunit of photosystem II (PS II); Region: Photosystem-II_D2; cd09288 43989001931 D1 interface; other site 43989001932 chlorophyll binding site; other site 43989001933 pheophytin binding site; other site 43989001934 beta carotene binding site; other site 43989001935 cytochrome b559 beta interface; other site 43989001936 quinone binding site; other site 43989001937 cytochrome b559 alpha interface; other site 43989001938 protein J interface; other site 43989001939 protein H interface; other site 43989001940 protein X interface; other site 43989001941 core light harvesting protein interface; other site 43989001942 protein L interface; other site 43989001943 CP43 interface; other site 43989001944 protein T interface; other site 43989001945 Fe binding site [ion binding]; other site 43989001946 protein M interface; other site 43989001947 Mn-stabilizing polypeptide interface; other site 43989001948 bromide binding site; other site 43989001949 cytochrome c-550 interface; other site 43989001950 Yqey-like protein; Region: YqeY; pfam09424 43989001951 Uncharacterized conserved protein [Function unknown]; Region: COG5607 43989001952 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05945 43989001953 L-aspartate oxidase; Provisional; Region: PRK06175 43989001954 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 43989001955 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 43989001956 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 43989001957 active site 43989001958 dimer interface [polypeptide binding]; other site 43989001959 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 43989001960 dimer interface [polypeptide binding]; other site 43989001961 active site 43989001962 6-phosphofructokinase; Provisional; Region: PRK14071 43989001963 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 43989001964 active site 43989001965 ADP/pyrophosphate binding site [chemical binding]; other site 43989001966 dimerization interface [polypeptide binding]; other site 43989001967 allosteric effector site; other site 43989001968 fructose-1,6-bisphosphate binding site; other site 43989001969 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 43989001970 excinuclease ABC subunit B; Provisional; Region: PRK05298 43989001971 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 43989001972 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 43989001973 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 43989001974 Domain of unknown function DUF20; Region: UPF0118; pfam01594 43989001975 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 43989001976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989001977 active site 43989001978 phosphorylation site [posttranslational modification] 43989001979 intermolecular recognition site; other site 43989001980 dimerization interface [polypeptide binding]; other site 43989001981 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 43989001982 DNA binding residues [nucleotide binding] 43989001983 dimerization interface [polypeptide binding]; other site 43989001984 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 43989001985 dimer interface [polypeptide binding]; other site 43989001986 [2Fe-2S] cluster binding site [ion binding]; other site 43989001987 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 43989001988 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 43989001989 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 43989001990 putative DNA binding site [nucleotide binding]; other site 43989001991 putative Zn2+ binding site [ion binding]; other site 43989001992 putative ABC transporter; Region: ycf24; CHL00085 43989001993 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 43989001994 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 43989001995 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 43989001996 Walker A/P-loop; other site 43989001997 ATP binding site [chemical binding]; other site 43989001998 Q-loop/lid; other site 43989001999 ABC transporter signature motif; other site 43989002000 Walker B; other site 43989002001 D-loop; other site 43989002002 H-loop/switch region; other site 43989002003 Uncharacterized conserved protein [Function unknown]; Region: COG5464 43989002004 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 43989002005 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 43989002006 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 43989002007 active site 43989002008 multimer interface [polypeptide binding]; other site 43989002009 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 43989002010 dimerization interface [polypeptide binding]; other site 43989002011 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 43989002012 metal binding site [ion binding]; metal-binding site 43989002013 active site 43989002014 I-site; other site 43989002015 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 43989002016 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 43989002017 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 43989002018 active site 1 [active] 43989002019 dimer interface [polypeptide binding]; other site 43989002020 hexamer interface [polypeptide binding]; other site 43989002021 active site 2 [active] 43989002022 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 43989002023 Coenzyme A binding pocket [chemical binding]; other site 43989002024 Methyltransferase domain; Region: Methyltransf_23; pfam13489 43989002025 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989002026 S-adenosylmethionine binding site [chemical binding]; other site 43989002027 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 43989002028 Cytochrome P450; Region: p450; cl12078 43989002029 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 43989002030 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 43989002031 Coenzyme A binding pocket [chemical binding]; other site 43989002032 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 43989002033 trimer interface [polypeptide binding]; other site 43989002034 active site 43989002035 substrate binding site [chemical binding]; other site 43989002036 CoA binding site [chemical binding]; other site 43989002037 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 43989002038 Ricin-type beta-trefoil; Region: RICIN; smart00458 43989002039 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 43989002040 putative sugar binding sites [chemical binding]; other site 43989002041 Q-X-W motif; other site 43989002042 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 43989002043 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 43989002044 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 43989002045 pyruvate kinase; Validated; Region: PRK08187 43989002046 domain interfaces; other site 43989002047 active site 43989002048 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 43989002049 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 43989002050 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 43989002051 active site 43989002052 metal binding site [ion binding]; metal-binding site 43989002053 elongation factor Ts; Reviewed; Region: tsf; PRK12332 43989002054 UBA/TS-N domain; Region: UBA; pfam00627 43989002055 Elongation factor TS; Region: EF_TS; pfam00889 43989002056 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 43989002057 rRNA interaction site [nucleotide binding]; other site 43989002058 S8 interaction site; other site 43989002059 putative laminin-1 binding site; other site 43989002060 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 43989002061 MoaE homodimer interface [polypeptide binding]; other site 43989002062 MoaD interaction [polypeptide binding]; other site 43989002063 active site residues [active] 43989002064 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317 43989002065 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 43989002066 active site 43989002067 substrate binding site [chemical binding]; other site 43989002068 metal binding site [ion binding]; metal-binding site 43989002069 multifunctional aminopeptidase A; Provisional; Region: PRK00913 43989002070 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 43989002071 interface (dimer of trimers) [polypeptide binding]; other site 43989002072 Substrate-binding/catalytic site; other site 43989002073 Zn-binding sites [ion binding]; other site 43989002074 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 43989002075 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 43989002076 putative ADP-binding pocket [chemical binding]; other site 43989002077 Response regulator receiver domain; Region: Response_reg; pfam00072 43989002078 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989002079 active site 43989002080 phosphorylation site [posttranslational modification] 43989002081 intermolecular recognition site; other site 43989002082 dimerization interface [polypeptide binding]; other site 43989002083 Response regulator receiver domain; Region: Response_reg; pfam00072 43989002084 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989002085 active site 43989002086 phosphorylation site [posttranslational modification] 43989002087 intermolecular recognition site; other site 43989002088 dimerization interface [polypeptide binding]; other site 43989002089 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 43989002090 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 43989002091 dimerization interface [polypeptide binding]; other site 43989002092 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 43989002093 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 43989002094 dimer interface [polypeptide binding]; other site 43989002095 putative CheW interface [polypeptide binding]; other site 43989002096 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 43989002097 putative binding surface; other site 43989002098 active site 43989002099 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 43989002100 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989002101 ATP binding site [chemical binding]; other site 43989002102 Mg2+ binding site [ion binding]; other site 43989002103 G-X-G motif; other site 43989002104 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 43989002105 Response regulator receiver domain; Region: Response_reg; pfam00072 43989002106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989002107 active site 43989002108 phosphorylation site [posttranslational modification] 43989002109 intermolecular recognition site; other site 43989002110 dimerization interface [polypeptide binding]; other site 43989002111 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 43989002112 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 43989002113 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 43989002114 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 43989002115 Peptidase family M23; Region: Peptidase_M23; pfam01551 43989002116 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 43989002117 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 43989002118 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 43989002119 active site 43989002120 catalytic residues [active] 43989002121 DNA binding site [nucleotide binding] 43989002122 Int/Topo IB signature motif; other site 43989002123 Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; pfam09250 43989002124 nucleotide binding site [chemical binding]; other site 43989002125 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 43989002126 AAA domain; Region: AAA_25; pfam13481 43989002127 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 43989002128 Walker A motif; other site 43989002129 ATP binding site [chemical binding]; other site 43989002130 Walker B motif; other site 43989002131 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 43989002132 Catalytic domain of Protein Kinases; Region: PKc; cd00180 43989002133 active site 43989002134 ATP binding site [chemical binding]; other site 43989002135 substrate binding site [chemical binding]; other site 43989002136 activation loop (A-loop); other site 43989002137 Part of AAA domain; Region: AAA_19; pfam13245 43989002138 AAA domain; Region: AAA_30; pfam13604 43989002139 AAA domain; Region: AAA_12; pfam13087 43989002140 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar5; cd09133 43989002141 PLD-like domain; Region: PLDc_2; pfam13091 43989002142 putative active site [active] 43989002143 putative catalytic site [active] 43989002144 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 43989002145 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 43989002146 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 43989002147 Peptidase family M48; Region: Peptidase_M48; cl12018 43989002148 FOG: WD40 repeat [General function prediction only]; Region: COG2319 43989002149 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 43989002150 structural tetrad; other site 43989002151 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 43989002152 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 43989002153 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 43989002154 Photosystem II reaction centre X protein (PsbX); Region: PsbX; pfam06596 43989002155 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 43989002156 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 43989002157 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 43989002158 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 43989002159 Uncharacterized conserved protein [Function unknown]; Region: COG2006 43989002160 Domain of unknown function (DUF362); Region: DUF362; pfam04015 43989002161 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 43989002162 Catalytic domain of Protein Kinases; Region: PKc; cd00180 43989002163 active site 43989002164 ATP binding site [chemical binding]; other site 43989002165 substrate binding site [chemical binding]; other site 43989002166 activation loop (A-loop); other site 43989002167 Uncharacterized conserved protein [Function unknown]; Region: COG1262 43989002168 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 43989002169 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 43989002170 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 43989002171 Walker A/P-loop; other site 43989002172 ATP binding site [chemical binding]; other site 43989002173 Q-loop/lid; other site 43989002174 ABC transporter signature motif; other site 43989002175 Walker B; other site 43989002176 D-loop; other site 43989002177 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 43989002178 Haemolytic domain; Region: Haemolytic; pfam01809 43989002179 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 43989002180 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 43989002181 active site 43989002182 purine riboside binding site [chemical binding]; other site 43989002183 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 43989002184 dimer interface [polypeptide binding]; other site 43989002185 conserved gate region; other site 43989002186 putative PBP binding loops; other site 43989002187 ABC-ATPase subunit interface; other site 43989002188 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 43989002189 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 43989002190 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 43989002191 ligand binding site; other site 43989002192 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 43989002193 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 43989002194 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 43989002195 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 43989002196 motif II; other site 43989002197 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 43989002198 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989002199 active site 43989002200 phosphorylation site [posttranslational modification] 43989002201 intermolecular recognition site; other site 43989002202 dimerization interface [polypeptide binding]; other site 43989002203 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 43989002204 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 43989002205 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989002206 Mg2+ binding site [ion binding]; other site 43989002207 G-X-G motif; other site 43989002208 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 43989002209 anchoring element; other site 43989002210 dimer interface [polypeptide binding]; other site 43989002211 ATP binding site [chemical binding]; other site 43989002212 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 43989002213 active site 43989002214 putative metal-binding site [ion binding]; other site 43989002215 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 43989002216 phosphodiesterase; Provisional; Region: PRK12704 43989002217 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 43989002218 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 43989002219 Mechanosensitive ion channel; Region: MS_channel; pfam00924 43989002220 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 43989002221 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 43989002222 active site 43989002223 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 43989002224 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989002225 binding surface 43989002226 TPR motif; other site 43989002227 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989002228 TPR motif; other site 43989002229 binding surface 43989002230 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989002231 binding surface 43989002232 TPR motif; other site 43989002233 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989002234 Methyltransferase domain; Region: Methyltransf_31; pfam13847 43989002235 S-adenosylmethionine binding site [chemical binding]; other site 43989002236 lipoyl synthase; Provisional; Region: PRK05481 43989002237 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 43989002238 FeS/SAM binding site; other site 43989002239 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 43989002240 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 43989002241 dimerization interface [polypeptide binding]; other site 43989002242 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 43989002243 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 43989002244 metal binding site [ion binding]; metal-binding site 43989002245 active site 43989002246 I-site; other site 43989002247 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 43989002248 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 43989002249 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 43989002250 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 43989002251 active site 43989002252 substrate binding site [chemical binding]; other site 43989002253 metal binding site [ion binding]; metal-binding site 43989002254 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 43989002255 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 43989002256 catalytic loop [active] 43989002257 iron binding site [ion binding]; other site 43989002258 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 43989002259 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 43989002260 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 43989002261 S4 domain; Region: S4_2; pfam13275 43989002262 Domain of unknown function DUF21; Region: DUF21; pfam01595 43989002263 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 43989002264 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 43989002265 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 43989002266 photosystem II protein PsbQ; Region: PS_II_psbQ_bact; TIGR03042 43989002267 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 43989002268 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 43989002269 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 43989002270 dinuclear metal binding motif [ion binding]; other site 43989002271 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 43989002272 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 43989002273 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 43989002274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 43989002275 dimer interface [polypeptide binding]; other site 43989002276 conserved gate region; other site 43989002277 ABC-ATPase subunit interface; other site 43989002278 SOUL heme-binding protein; Region: SOUL; pfam04832 43989002279 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 43989002280 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 43989002281 active site 43989002282 catalytic tetrad [active] 43989002283 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 43989002284 Mechanosensitive ion channel; Region: MS_channel; pfam00924 43989002285 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 43989002286 Glucose inhibited division protein A; Region: GIDA; pfam01134 43989002287 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989002288 putative active site [active] 43989002289 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 43989002290 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 43989002291 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 43989002292 active site 43989002293 catalytic residues [active] 43989002294 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 43989002295 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 43989002296 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 43989002297 active site 43989002298 metal binding site [ion binding]; metal-binding site 43989002299 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 43989002300 Methyltransferase domain; Region: Methyltransf_31; pfam13847 43989002301 Predicted metal-binding protein [General function prediction only]; Region: COG3019 43989002302 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 43989002303 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 43989002304 Multicopper oxidase; Region: Cu-oxidase; pfam00394 43989002305 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 43989002306 Peptidase family M48; Region: Peptidase_M48; pfam01435 43989002307 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 43989002308 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 43989002309 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 43989002310 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 43989002311 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 43989002312 substrate binding site [chemical binding]; other site 43989002313 hexamer interface [polypeptide binding]; other site 43989002314 metal binding site [ion binding]; metal-binding site 43989002315 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 43989002316 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 43989002317 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 43989002318 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 43989002319 propionate/acetate kinase; Provisional; Region: PRK12379 43989002320 ribosomal protein L19; Region: rpl19; CHL00084 43989002321 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 43989002322 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 43989002323 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 43989002324 homodimer interface [polypeptide binding]; other site 43989002325 Walker A motif; other site 43989002326 ATP binding site [chemical binding]; other site 43989002327 hydroxycobalamin binding site [chemical binding]; other site 43989002328 Walker B motif; other site 43989002329 Maf-like protein; Region: Maf; pfam02545 43989002330 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 43989002331 active site 43989002332 dimer interface [polypeptide binding]; other site 43989002333 PsbP; Region: PsbP; pfam01789 43989002334 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645 43989002335 ATP-NAD kinase; Region: NAD_kinase; pfam01513 43989002336 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 43989002337 iron-sulfur cluster [ion binding]; other site 43989002338 [2Fe-2S] cluster binding site [ion binding]; other site 43989002339 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 43989002340 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 43989002341 glycogen binding site [chemical binding]; other site 43989002342 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350 43989002343 active site 43989002344 catalytic site [active] 43989002345 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 43989002346 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 43989002347 conserved hypothetical protein; Region: TIGR03492 43989002348 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186 43989002349 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 43989002350 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 43989002351 homodimer interface [polypeptide binding]; other site 43989002352 NADP binding site [chemical binding]; other site 43989002353 substrate binding site [chemical binding]; other site 43989002354 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 43989002355 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 43989002356 nudix motif; other site 43989002357 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 43989002358 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 43989002359 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 43989002360 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989002361 active site 43989002362 phosphorylation site [posttranslational modification] 43989002363 intermolecular recognition site; other site 43989002364 dimerization interface [polypeptide binding]; other site 43989002365 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 43989002366 DNA binding site [nucleotide binding] 43989002367 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 43989002368 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 43989002369 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 43989002370 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 43989002371 Protein of unknown function (DUF3571); Region: DUF3571; pfam12095 43989002372 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 43989002373 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 43989002374 DRTGG domain; Region: DRTGG; pfam07085 43989002375 DDE superfamily endonuclease; Region: DDE_5; cl17874 43989002376 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 43989002377 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 43989002378 Sulfate transporter family; Region: Sulfate_transp; pfam00916 43989002379 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 43989002380 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 43989002381 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 43989002382 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 43989002383 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 43989002384 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 43989002385 non-specific DNA binding site [nucleotide binding]; other site 43989002386 salt bridge; other site 43989002387 sequence-specific DNA binding site [nucleotide binding]; other site 43989002388 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 43989002389 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 43989002390 substrate binding site [chemical binding]; other site 43989002391 oxyanion hole (OAH) forming residues; other site 43989002392 trimer interface [polypeptide binding]; other site 43989002393 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 43989002394 Methyltransferase domain; Region: Methyltransf_23; pfam13489 43989002395 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989002396 S-adenosylmethionine binding site [chemical binding]; other site 43989002397 Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932 43989002398 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 43989002399 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 43989002400 homotetramer interface [polypeptide binding]; other site 43989002401 ligand binding site [chemical binding]; other site 43989002402 catalytic site [active] 43989002403 NAD binding site [chemical binding]; other site 43989002404 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 43989002405 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 43989002406 putative acyl-acceptor binding pocket; other site 43989002407 Amino acid permease; Region: AA_permease; pfam00324 43989002408 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 43989002409 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 43989002410 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 43989002411 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 43989002412 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 43989002413 ligand binding site [chemical binding]; other site 43989002414 homodimer interface [polypeptide binding]; other site 43989002415 NAD(P) binding site [chemical binding]; other site 43989002416 trimer interface B [polypeptide binding]; other site 43989002417 trimer interface A [polypeptide binding]; other site 43989002418 molybdenum-pterin binding domain; Region: Mop; TIGR00638 43989002419 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 43989002420 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 43989002421 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 43989002422 Soluble P-type ATPase [General function prediction only]; Region: COG4087 43989002423 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 43989002424 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 43989002425 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 43989002426 Amidohydrolase; Region: Amidohydro_2; pfam04909 43989002427 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 43989002428 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 43989002429 EamA-like transporter family; Region: EamA; pfam00892 43989002430 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 43989002431 active site 43989002432 excinuclease ABC subunit A; Provisional; Region: PRK00635 43989002433 Uncharacterized conserved protein [Function unknown]; Region: COG2968 43989002434 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 43989002435 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 43989002436 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 43989002437 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 43989002438 photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624 43989002439 twin arginine translocase protein A; Provisional; Region: tatA; PRK14857 43989002440 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 43989002441 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 43989002442 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 43989002443 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989002444 putative active site [active] 43989002445 PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855 43989002446 putative active site [active] 43989002447 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 43989002448 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989002449 putative active site [active] 43989002450 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 43989002451 HlyD family secretion protein; Region: HlyD_3; pfam13437 43989002452 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 43989002453 active site clefts [active] 43989002454 zinc binding site [ion binding]; other site 43989002455 dimer interface [polypeptide binding]; other site 43989002456 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 43989002457 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 43989002458 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 43989002459 RNA polymerase sigma factor RpoD; Validated; Region: PRK07406 43989002460 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 43989002461 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 43989002462 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 43989002463 DNA binding residues [nucleotide binding] 43989002464 Divergent PAP2 family; Region: DUF212; pfam02681 43989002465 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 43989002466 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 43989002467 substrate binding pocket [chemical binding]; other site 43989002468 chain length determination region; other site 43989002469 substrate-Mg2+ binding site; other site 43989002470 catalytic residues [active] 43989002471 aspartate-rich region 1; other site 43989002472 active site lid residues [active] 43989002473 aspartate-rich region 2; other site 43989002474 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 43989002475 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 43989002476 active site 43989002477 (T/H)XGH motif; other site 43989002478 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 43989002479 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 43989002480 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 43989002481 Domain of unknown function DUF29; Region: DUF29; pfam01724 43989002482 phosphate transporter ATP-binding protein; Provisional; Region: PRK14243 43989002483 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 43989002484 Walker A/P-loop; other site 43989002485 ATP binding site [chemical binding]; other site 43989002486 Q-loop/lid; other site 43989002487 ABC transporter signature motif; other site 43989002488 Walker B; other site 43989002489 D-loop; other site 43989002490 H-loop/switch region; other site 43989002491 phosphate transporter ATP-binding protein; Provisional; Region: PRK14243 43989002492 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 43989002493 Walker A/P-loop; other site 43989002494 ATP binding site [chemical binding]; other site 43989002495 Q-loop/lid; other site 43989002496 ABC transporter signature motif; other site 43989002497 Walker B; other site 43989002498 D-loop; other site 43989002499 H-loop/switch region; other site 43989002500 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 43989002501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 43989002502 dimer interface [polypeptide binding]; other site 43989002503 conserved gate region; other site 43989002504 putative PBP binding loops; other site 43989002505 ABC-ATPase subunit interface; other site 43989002506 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 43989002507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 43989002508 dimer interface [polypeptide binding]; other site 43989002509 conserved gate region; other site 43989002510 putative PBP binding loops; other site 43989002511 ABC-ATPase subunit interface; other site 43989002512 PBP superfamily domain; Region: PBP_like_2; cl17296 43989002513 PBP superfamily domain; Region: PBP_like_2; cl17296 43989002514 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 43989002515 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 43989002516 dimerization interface [polypeptide binding]; other site 43989002517 PAS domain; Region: PAS; smart00091 43989002518 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989002519 dimer interface [polypeptide binding]; other site 43989002520 phosphorylation site [posttranslational modification] 43989002521 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989002522 ATP binding site [chemical binding]; other site 43989002523 Mg2+ binding site [ion binding]; other site 43989002524 G-X-G motif; other site 43989002525 Double zinc ribbon; Region: DZR; pfam12773 43989002526 glycogen synthase; Provisional; Region: glgA; PRK00654 43989002527 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 43989002528 ADP-binding pocket [chemical binding]; other site 43989002529 homodimer interface [polypeptide binding]; other site 43989002530 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 43989002531 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 43989002532 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 43989002533 catalytic loop [active] 43989002534 iron binding site [ion binding]; other site 43989002535 photosystem II reaction center protein M; Provisional; Region: psbM; PRK04989 43989002536 hypothetical protein; Validated; Region: PRK00110 43989002537 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 43989002538 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 43989002539 ATP binding site [chemical binding]; other site 43989002540 putative Mg++ binding site [ion binding]; other site 43989002541 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 43989002542 nucleotide binding region [chemical binding]; other site 43989002543 ATP-binding site [chemical binding]; other site 43989002544 Predicted membrane protein [Function unknown]; Region: COG1950 43989002545 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 43989002546 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 43989002547 putative catalytic cysteine [active] 43989002548 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 43989002549 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 43989002550 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 43989002551 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 43989002552 catalytic site [active] 43989002553 subunit interface [polypeptide binding]; other site 43989002554 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 43989002555 DNA-binding interface [nucleotide binding]; DNA binding site 43989002556 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 43989002557 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989002558 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989002559 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989002560 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989002561 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989002562 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989002563 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 43989002564 non-specific DNA binding site [nucleotide binding]; other site 43989002565 salt bridge; other site 43989002566 sequence-specific DNA binding site [nucleotide binding]; other site 43989002567 Domain of unknown function (DUF955); Region: DUF955; pfam06114 43989002568 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 43989002569 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 43989002570 Walker A/P-loop; other site 43989002571 ATP binding site [chemical binding]; other site 43989002572 Q-loop/lid; other site 43989002573 ABC transporter signature motif; other site 43989002574 Walker B; other site 43989002575 D-loop; other site 43989002576 H-loop/switch region; other site 43989002577 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 43989002578 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 43989002579 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 43989002580 Mg++ binding site [ion binding]; other site 43989002581 putative catalytic motif [active] 43989002582 putative substrate binding site [chemical binding]; other site 43989002583 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 43989002584 active site 43989002585 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 43989002586 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 43989002587 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 43989002588 RNA binding surface [nucleotide binding]; other site 43989002589 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 43989002590 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 43989002591 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 43989002592 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989002593 putative active site [active] 43989002594 phycobillisome linker protein; Region: apcE; CHL00091 43989002595 Phycobilisome protein; Region: Phycobilisome; cl08227 43989002596 Phycobilisome protein; Region: Phycobilisome; cl08227 43989002597 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 43989002598 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 43989002599 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 43989002600 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812 43989002601 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 43989002602 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 43989002603 active site 43989002604 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 43989002605 Domain of unknown function DUF59; Region: DUF59; pfam01883 43989002606 antiporter inner membrane protein; Provisional; Region: PRK11670 43989002607 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 43989002608 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 43989002609 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 43989002610 putative active site [active] 43989002611 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 43989002612 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 43989002613 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 43989002614 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 43989002615 active site 43989002616 SAM binding site [chemical binding]; other site 43989002617 homodimer interface [polypeptide binding]; other site 43989002618 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 43989002619 seryl-tRNA synthetase; Provisional; Region: PRK05431 43989002620 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 43989002621 dimer interface [polypeptide binding]; other site 43989002622 active site 43989002623 motif 1; other site 43989002624 motif 2; other site 43989002625 motif 3; other site 43989002626 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 43989002627 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 43989002628 Coenzyme A binding pocket [chemical binding]; other site 43989002629 PIN domain; Region: PIN_2; cl17859 43989002630 PIN domain; Region: PIN_2; cl17859 43989002631 Homeodomain-like domain; Region: HTH_23; pfam13384 43989002632 DDE superfamily endonuclease; Region: DDE_3; pfam13358 43989002633 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 43989002634 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 43989002635 Aspartyl protease; Region: Asp_protease_2; pfam13650 43989002636 inhibitor binding site; inhibition site 43989002637 catalytic motif [active] 43989002638 Catalytic residue [active] 43989002639 Active site flap [active] 43989002640 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 43989002641 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 43989002642 motif II; other site 43989002643 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 43989002644 tetramerization interface [polypeptide binding]; other site 43989002645 active site 43989002646 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 43989002647 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 43989002648 dimer interface [polypeptide binding]; other site 43989002649 conserved gate region; other site 43989002650 putative PBP binding loops; other site 43989002651 ABC-ATPase subunit interface; other site 43989002652 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 43989002653 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 43989002654 dimer interface [polypeptide binding]; other site 43989002655 conserved gate region; other site 43989002656 putative PBP binding loops; other site 43989002657 ABC-ATPase subunit interface; other site 43989002658 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 43989002659 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 43989002660 Protein required for attachment to host cells; Region: Host_attach; pfam10116 43989002661 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 43989002662 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 43989002663 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989002664 putative active site [active] 43989002665 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 43989002666 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 43989002667 Walker A/P-loop; other site 43989002668 ATP binding site [chemical binding]; other site 43989002669 Q-loop/lid; other site 43989002670 ABC transporter signature motif; other site 43989002671 Walker B; other site 43989002672 D-loop; other site 43989002673 H-loop/switch region; other site 43989002674 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 43989002675 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 43989002676 putative active site [active] 43989002677 substrate binding site [chemical binding]; other site 43989002678 putative cosubstrate binding site; other site 43989002679 catalytic site [active] 43989002680 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 43989002681 substrate binding site [chemical binding]; other site 43989002682 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 43989002683 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 43989002684 putative active site [active] 43989002685 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 43989002686 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 43989002687 dimer interface [polypeptide binding]; other site 43989002688 PYR/PP interface [polypeptide binding]; other site 43989002689 TPP binding site [chemical binding]; other site 43989002690 substrate binding site [chemical binding]; other site 43989002691 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 43989002692 Domain of unknown function; Region: EKR; pfam10371 43989002693 4Fe-4S binding domain; Region: Fer4_6; pfam12837 43989002694 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 43989002695 TPP-binding site [chemical binding]; other site 43989002696 dimer interface [polypeptide binding]; other site 43989002697 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 43989002698 FeS/SAM binding site; other site 43989002699 DNA methylase; Region: N6_N4_Mtase; cl17433 43989002700 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 43989002701 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 43989002702 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 43989002703 active site 43989002704 Riboflavin kinase; Region: Flavokinase; pfam01687 43989002705 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 43989002706 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 43989002707 active site 43989002708 Zn binding site [ion binding]; other site 43989002709 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 43989002710 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 43989002711 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 43989002712 active site 43989002713 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 43989002714 substrate binding site; other site 43989002715 dimer interface; other site 43989002716 Domain of unknown function (DUF1802); Region: DUF1802; pfam08819 43989002717 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 43989002718 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 43989002719 Substrate binding site; other site 43989002720 Mg++ binding site; other site 43989002721 metal-binding site 43989002722 Mg++ binding site; other site 43989002723 metal-binding site 43989002724 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 43989002725 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 43989002726 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 43989002727 Recombinase; Region: Recombinase; pfam07508 43989002728 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 43989002729 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 43989002730 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989002731 dimer interface [polypeptide binding]; other site 43989002732 phosphorylation site [posttranslational modification] 43989002733 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989002734 ATP binding site [chemical binding]; other site 43989002735 Mg2+ binding site [ion binding]; other site 43989002736 G-X-G motif; other site 43989002737 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 43989002738 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989002739 active site 43989002740 phosphorylation site [posttranslational modification] 43989002741 intermolecular recognition site; other site 43989002742 dimerization interface [polypeptide binding]; other site 43989002743 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 43989002744 DNA binding site [nucleotide binding] 43989002745 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 43989002746 4Fe-4S binding domain; Region: Fer4; cl02805 43989002747 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 43989002748 TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950 43989002749 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 43989002750 catalytic residues [active] 43989002751 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 43989002752 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 43989002753 N- and C-terminal domain interface [polypeptide binding]; other site 43989002754 active site 43989002755 MgATP binding site [chemical binding]; other site 43989002756 catalytic site [active] 43989002757 metal binding site [ion binding]; metal-binding site 43989002758 glycerol binding site [chemical binding]; other site 43989002759 homotetramer interface [polypeptide binding]; other site 43989002760 homodimer interface [polypeptide binding]; other site 43989002761 FBP binding site [chemical binding]; other site 43989002762 protein IIAGlc interface [polypeptide binding]; other site 43989002763 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 43989002764 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 43989002765 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 43989002766 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 43989002767 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 43989002768 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 43989002769 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 43989002770 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 43989002771 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 43989002772 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989002773 putative active site [active] 43989002774 Methyltransferase domain; Region: Methyltransf_31; pfam13847 43989002775 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989002776 S-adenosylmethionine binding site [chemical binding]; other site 43989002777 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 43989002778 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 43989002779 ligand binding site; other site 43989002780 oligomer interface; other site 43989002781 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 43989002782 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 43989002783 dimer interface [polypeptide binding]; other site 43989002784 N-terminal domain interface [polypeptide binding]; other site 43989002785 sulfate 1 binding site; other site 43989002786 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 43989002787 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 43989002788 active site 43989002789 motif I; other site 43989002790 motif II; other site 43989002791 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 43989002792 photosystem I P700 chlorophyll a apoprotein A1; Region: psaA; CHL00056 43989002793 photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199 43989002794 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 43989002795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 43989002796 dimer interface [polypeptide binding]; other site 43989002797 conserved gate region; other site 43989002798 putative PBP binding loops; other site 43989002799 ABC-ATPase subunit interface; other site 43989002800 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 43989002801 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 43989002802 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 43989002803 dimerization interface [polypeptide binding]; other site 43989002804 FAD binding pocket [chemical binding]; other site 43989002805 FAD binding motif [chemical binding]; other site 43989002806 catalytic residues [active] 43989002807 NAD binding pocket [chemical binding]; other site 43989002808 phosphate binding motif [ion binding]; other site 43989002809 beta-alpha-beta structure motif; other site 43989002810 phosphoribulokinase; Provisional; Region: PRK07429 43989002811 Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026 43989002812 active site 43989002813 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 43989002814 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 43989002815 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 43989002816 NAD(P) binding site [chemical binding]; other site 43989002817 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 43989002818 active site 43989002819 photosystem I reaction center subunit PsaK; Region: PS_I_psaK; TIGR03049 43989002820 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 43989002821 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 43989002822 phosphopeptide binding site; other site 43989002823 Clp protease ATP binding subunit; Region: clpC; CHL00095 43989002824 Clp amino terminal domain; Region: Clp_N; pfam02861 43989002825 Clp amino terminal domain; Region: Clp_N; pfam02861 43989002826 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 43989002827 Walker A motif; other site 43989002828 ATP binding site [chemical binding]; other site 43989002829 Walker B motif; other site 43989002830 arginine finger; other site 43989002831 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 43989002832 Walker A motif; other site 43989002833 ATP binding site [chemical binding]; other site 43989002834 Walker B motif; other site 43989002835 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 43989002836 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 43989002837 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 43989002838 DXD motif; other site 43989002839 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 43989002840 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 43989002841 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 43989002842 catalytic residue [active] 43989002843 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 43989002844 FeS assembly protein SufD; Region: sufD; TIGR01981 43989002845 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 43989002846 FAD binding domain; Region: FAD_binding_4; pfam01565 43989002847 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 43989002848 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 43989002849 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 43989002850 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 43989002851 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 43989002852 FeS/SAM binding site; other site 43989002853 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 43989002854 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 43989002855 Soluble P-type ATPase [General function prediction only]; Region: COG4087 43989002856 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 43989002857 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 43989002858 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 43989002859 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 43989002860 putative acyl-acceptor binding pocket; other site 43989002861 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 43989002862 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 43989002863 catalytic site [active] 43989002864 putative active site [active] 43989002865 putative substrate binding site [chemical binding]; other site 43989002866 NifU-like domain; Region: NifU; pfam01106 43989002867 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 43989002868 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 43989002869 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 43989002870 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 43989002871 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 43989002872 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 43989002873 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 43989002874 Cytochrome P450; Region: p450; cl12078 43989002875 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 43989002876 active site 43989002877 DDE superfamily endonuclease; Region: DDE_3; pfam13358 43989002878 Homeodomain-like domain; Region: HTH_23; pfam13384 43989002879 Winged helix-turn helix; Region: HTH_29; pfam13551 43989002880 Homeodomain-like domain; Region: HTH_32; pfam13565 43989002881 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 43989002882 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 43989002883 acyl-activating enzyme (AAE) consensus motif; other site 43989002884 succinyldiaminopimelate transaminase; Validated; Region: PRK07366 43989002885 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 43989002886 pyridoxal 5'-phosphate binding site [chemical binding]; other site 43989002887 homodimer interface [polypeptide binding]; other site 43989002888 catalytic residue [active] 43989002889 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 43989002890 catalytic residues [active] 43989002891 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 43989002892 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 43989002893 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 43989002894 active site 43989002895 HIGH motif; other site 43989002896 dimer interface [polypeptide binding]; other site 43989002897 KMSKS motif; other site 43989002898 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 43989002899 Ferritin-like domain; Region: Ferritin; pfam00210 43989002900 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 43989002901 dinuclear metal binding motif [ion binding]; other site 43989002902 Iron permease FTR1 family; Region: FTR1; cl00475 43989002903 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 43989002904 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 43989002905 putative ligand binding site [chemical binding]; other site 43989002906 von Willebrand factor type A domain; Region: VWA_2; pfam13519 43989002907 Predicted GTPase [General function prediction only]; Region: COG3596 43989002908 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 43989002909 G1 box; other site 43989002910 GTP/Mg2+ binding site [chemical binding]; other site 43989002911 G2 box; other site 43989002912 Switch I region; other site 43989002913 G3 box; other site 43989002914 Switch II region; other site 43989002915 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 43989002916 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 43989002917 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 43989002918 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 43989002919 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 43989002920 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 43989002921 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 43989002922 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 43989002923 Fasciclin domain; Region: Fasciclin; pfam02469 43989002924 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 43989002925 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989002926 putative active site [active] 43989002927 Amidases related to nicotinamidase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PncA; COG1335 43989002928 catalytic triad [active] 43989002929 conserved cis-peptide bond; other site 43989002930 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 43989002931 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 43989002932 MPN+ (JAMM) motif; other site 43989002933 Zinc-binding site [ion binding]; other site 43989002934 L-asparaginase II; Region: Asparaginase_II; cl01842 43989002935 Protein of unknown function (DUF1230); Region: DUF1230; pfam06799 43989002936 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 43989002937 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 43989002938 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 43989002939 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 43989002940 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 43989002941 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 43989002942 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 43989002943 sensory histidine kinase UhpB; Provisional; Region: PRK11644 43989002944 Tubulin like; Region: Tubulin_2; pfam13809 43989002945 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 43989002946 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 43989002947 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 43989002948 Restriction endonuclease BsobI; Region: Endonuc-BsobI; pfam09194 43989002949 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 43989002950 magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031 43989002951 Walker A motif; other site 43989002952 ATP binding site [chemical binding]; other site 43989002953 Walker B motif; other site 43989002954 arginine finger; other site 43989002955 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 43989002956 metal ion-dependent adhesion site (MIDAS); other site 43989002957 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 43989002958 FOG: WD40 repeat [General function prediction only]; Region: COG2319 43989002959 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 43989002960 structural tetrad; other site 43989002961 WD domain, G-beta repeat; Region: WD40; pfam00400 43989002962 WD40 repeats; Region: WD40; smart00320 43989002963 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 43989002964 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 43989002965 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 43989002966 GUN4-like; Region: GUN4; pfam05419 43989002967 Circadian oscillating protein COP23; Region: COP23; pfam14218 43989002968 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319 43989002969 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 43989002970 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 43989002971 dimerization interface [polypeptide binding]; other site 43989002972 active site 43989002973 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 43989002974 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 43989002975 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 43989002976 active site 43989002977 metal binding site [ion binding]; metal-binding site 43989002978 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 43989002979 active site 43989002980 metal binding site [ion binding]; metal-binding site 43989002981 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989002982 TPR motif; other site 43989002983 binding surface 43989002984 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989002985 putative active site [active] 43989002986 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 43989002987 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 43989002988 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 43989002989 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 43989002990 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 43989002991 putative dimer interface [polypeptide binding]; other site 43989002992 active site pocket [active] 43989002993 putative cataytic base [active] 43989002994 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 43989002995 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 43989002996 putative active site [active] 43989002997 putative NTP binding site [chemical binding]; other site 43989002998 putative nucleic acid binding site [nucleotide binding]; other site 43989002999 PIN domain; Region: PIN_3; cl17397 43989003000 Amino acid permease; Region: AA_permease; pfam00324 43989003001 Predicted membrane protein [Function unknown]; Region: COG1950 43989003002 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 43989003003 TROVE domain; Region: TROVE; pfam05731 43989003004 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 43989003005 metal ion-dependent adhesion site (MIDAS); other site 43989003006 Domain of unknown function DUF29; Region: DUF29; pfam01724 43989003007 Methyltransferase domain; Region: Methyltransf_26; pfam13659 43989003008 DDE superfamily endonuclease; Region: DDE_4; pfam13359 43989003009 Predicted helicase [General function prediction only]; Region: COG4889 43989003010 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 43989003011 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 43989003012 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 43989003013 Protein of unknown function (DUF3082); Region: DUF3082; pfam11282 43989003014 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 43989003015 Cytochrome c; Region: Cytochrom_C; cl11414 43989003016 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371 43989003017 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 43989003018 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989003019 putative active site [active] 43989003020 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 43989003021 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 43989003022 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_1; cd03400 43989003023 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 43989003024 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 43989003025 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 43989003026 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 43989003027 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 43989003028 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137 43989003029 serpin-like protein; Provisional; Region: PHA02660 43989003030 reactive center loop; other site 43989003031 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 43989003032 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 43989003033 active site residue [active] 43989003034 AAA domain; Region: AAA_17; pfam13207 43989003035 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 43989003036 aspartate aminotransferase; Provisional; Region: PRK05957 43989003037 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 43989003038 pyridoxal 5'-phosphate binding site [chemical binding]; other site 43989003039 homodimer interface [polypeptide binding]; other site 43989003040 catalytic residue [active] 43989003041 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 43989003042 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 43989003043 replicative DNA helicase; Provisional; Region: PRK05973 43989003044 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 43989003045 Walker A motif; other site 43989003046 ATP binding site [chemical binding]; other site 43989003047 Walker B motif; other site 43989003048 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 43989003049 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 43989003050 quinone interaction residues [chemical binding]; other site 43989003051 active site 43989003052 catalytic residues [active] 43989003053 FMN binding site [chemical binding]; other site 43989003054 substrate binding site [chemical binding]; other site 43989003055 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 43989003056 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 43989003057 non-specific DNA binding site [nucleotide binding]; other site 43989003058 salt bridge; other site 43989003059 sequence-specific DNA binding site [nucleotide binding]; other site 43989003060 Domain of unknown function (DUF955); Region: DUF955; pfam06114 43989003061 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 43989003062 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 43989003063 Catalytic domain of Protein Kinases; Region: PKc; cd00180 43989003064 active site 43989003065 ATP binding site [chemical binding]; other site 43989003066 substrate binding site [chemical binding]; other site 43989003067 activation loop (A-loop); other site 43989003068 FOG: WD40 repeat [General function prediction only]; Region: COG2319 43989003069 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 43989003070 structural tetrad; other site 43989003071 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 43989003072 structural tetrad; other site 43989003073 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 43989003074 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 43989003075 acyl-activating enzyme (AAE) consensus motif; other site 43989003076 putative AMP binding site [chemical binding]; other site 43989003077 putative active site [active] 43989003078 putative CoA binding site [chemical binding]; other site 43989003079 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 43989003080 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 43989003081 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989003082 active site 43989003083 phosphorylation site [posttranslational modification] 43989003084 intermolecular recognition site; other site 43989003085 dimerization interface [polypeptide binding]; other site 43989003086 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 43989003087 DNA binding residues [nucleotide binding] 43989003088 dimerization interface [polypeptide binding]; other site 43989003089 GTP-binding protein YchF; Reviewed; Region: PRK09601 43989003090 YchF GTPase; Region: YchF; cd01900 43989003091 G1 box; other site 43989003092 GTP/Mg2+ binding site [chemical binding]; other site 43989003093 Switch I region; other site 43989003094 G2 box; other site 43989003095 Switch II region; other site 43989003096 G3 box; other site 43989003097 G4 box; other site 43989003098 G5 box; other site 43989003099 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 43989003100 Response regulator receiver domain; Region: Response_reg; pfam00072 43989003101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989003102 active site 43989003103 phosphorylation site [posttranslational modification] 43989003104 intermolecular recognition site; other site 43989003105 dimerization interface [polypeptide binding]; other site 43989003106 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 43989003107 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 43989003108 metal binding site [ion binding]; metal-binding site 43989003109 active site 43989003110 I-site; other site 43989003111 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 43989003112 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 43989003113 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 43989003114 substrate binding pocket [chemical binding]; other site 43989003115 membrane-bound complex binding site; other site 43989003116 hinge residues; other site 43989003117 PAS domain S-box; Region: sensory_box; TIGR00229 43989003118 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989003119 putative active site [active] 43989003120 heme pocket [chemical binding]; other site 43989003121 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 43989003122 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 43989003123 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 43989003124 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989003125 dimer interface [polypeptide binding]; other site 43989003126 phosphorylation site [posttranslational modification] 43989003127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989003128 ATP binding site [chemical binding]; other site 43989003129 Mg2+ binding site [ion binding]; other site 43989003130 G-X-G motif; other site 43989003131 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 43989003132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989003133 active site 43989003134 phosphorylation site [posttranslational modification] 43989003135 intermolecular recognition site; other site 43989003136 dimerization interface [polypeptide binding]; other site 43989003137 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 43989003138 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 43989003139 dimerization interface [polypeptide binding]; other site 43989003140 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 43989003141 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 43989003142 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 43989003143 G1 box; other site 43989003144 putative GEF interaction site [polypeptide binding]; other site 43989003145 GTP/Mg2+ binding site [chemical binding]; other site 43989003146 Switch I region; other site 43989003147 G2 box; other site 43989003148 G3 box; other site 43989003149 Switch II region; other site 43989003150 G4 box; other site 43989003151 G5 box; other site 43989003152 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 43989003153 Domain of unknown function DUF29; Region: DUF29; pfam01724 43989003154 Domain of unknown function DUF29; Region: DUF29; pfam01724 43989003155 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989003156 putative active site [active] 43989003157 AAA ATPase domain; Region: AAA_16; pfam13191 43989003158 WD40 repeats; Region: WD40; smart00320 43989003159 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 43989003160 structural tetrad; other site 43989003161 FOG: WD40 repeat [General function prediction only]; Region: COG2319 43989003162 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 43989003163 structural tetrad; other site 43989003164 WD40 repeats; Region: WD40; smart00320 43989003165 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 43989003166 active site 43989003167 NTP binding site [chemical binding]; other site 43989003168 metal binding triad [ion binding]; metal-binding site 43989003169 antibiotic binding site [chemical binding]; other site 43989003170 AAA ATPase domain; Region: AAA_16; pfam13191 43989003171 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 43989003172 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 43989003173 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 43989003174 Peptidase family M48; Region: Peptidase_M48; pfam01435 43989003175 Family of unknown function (DUF490); Region: DUF490; pfam04357 43989003176 EamA-like transporter family; Region: EamA; pfam00892 43989003177 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989003178 binding surface 43989003179 Tetratricopeptide repeat; Region: TPR_16; pfam13432 43989003180 TPR motif; other site 43989003181 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989003182 binding surface 43989003183 TPR motif; other site 43989003184 TPR repeat; Region: TPR_11; pfam13414 43989003185 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 43989003186 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 43989003187 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 43989003188 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 43989003189 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 43989003190 PBP superfamily domain; Region: PBP_like_2; cl17296 43989003191 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 43989003192 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 43989003193 dimer interface [polypeptide binding]; other site 43989003194 conserved gate region; other site 43989003195 putative PBP binding loops; other site 43989003196 ABC-ATPase subunit interface; other site 43989003197 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 43989003198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 43989003199 dimer interface [polypeptide binding]; other site 43989003200 conserved gate region; other site 43989003201 putative PBP binding loops; other site 43989003202 ABC-ATPase subunit interface; other site 43989003203 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 43989003204 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 43989003205 Walker A/P-loop; other site 43989003206 ATP binding site [chemical binding]; other site 43989003207 Q-loop/lid; other site 43989003208 ABC transporter signature motif; other site 43989003209 Walker B; other site 43989003210 D-loop; other site 43989003211 H-loop/switch region; other site 43989003212 Protein of unknown function (DUF3148); Region: DUF3148; pfam11347 43989003213 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 43989003214 Low molecular weight phosphatase family; Region: LMWPc; cd00115 43989003215 active site 43989003216 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 43989003217 oxyanion hole [active] 43989003218 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 43989003219 catalytic triad [active] 43989003220 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 43989003221 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 43989003222 Probable Catalytic site; other site 43989003223 metal-binding site 43989003224 Uncharacterized conserved protein [Function unknown]; Region: COG2912 43989003225 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 43989003226 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989003227 binding surface 43989003228 TPR motif; other site 43989003229 DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cd04371 43989003230 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 43989003231 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 43989003232 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 43989003233 TMP-binding site; other site 43989003234 ATP-binding site [chemical binding]; other site 43989003235 MAPEG family; Region: MAPEG; pfam01124 43989003236 NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504 43989003237 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 43989003238 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 43989003239 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 43989003240 putative C-terminal domain interface [polypeptide binding]; other site 43989003241 putative GSH binding site (G-site) [chemical binding]; other site 43989003242 putative dimer interface [polypeptide binding]; other site 43989003243 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 43989003244 N-terminal domain interface [polypeptide binding]; other site 43989003245 dimer interface [polypeptide binding]; other site 43989003246 substrate binding pocket (H-site) [chemical binding]; other site 43989003247 S-layer homology domain; Region: SLH; pfam00395 43989003248 S-layer homology domain; Region: SLH; pfam00395 43989003249 S-layer homology domain; Region: SLH; pfam00395 43989003250 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 43989003251 5'-methylthioadenosine phosphorylase; Provisional; Region: PRK07432 43989003252 Protein of unknown function (DUF721); Region: DUF721; pfam05258 43989003253 Stage II sporulation protein; Region: SpoIID; pfam08486 43989003254 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 43989003255 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989003256 active site 43989003257 phosphorylation site [posttranslational modification] 43989003258 intermolecular recognition site; other site 43989003259 dimerization interface [polypeptide binding]; other site 43989003260 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989003261 PAS fold; Region: PAS_3; pfam08447 43989003262 putative active site [active] 43989003263 heme pocket [chemical binding]; other site 43989003264 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 43989003265 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 43989003266 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989003267 dimer interface [polypeptide binding]; other site 43989003268 phosphorylation site [posttranslational modification] 43989003269 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989003270 ATP binding site [chemical binding]; other site 43989003271 Mg2+ binding site [ion binding]; other site 43989003272 G-X-G motif; other site 43989003273 Response regulator receiver domain; Region: Response_reg; pfam00072 43989003274 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989003275 active site 43989003276 phosphorylation site [posttranslational modification] 43989003277 intermolecular recognition site; other site 43989003278 dimerization interface [polypeptide binding]; other site 43989003279 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 43989003280 GAF domain; Region: GAF; pfam01590 43989003281 PAS fold; Region: PAS_4; pfam08448 43989003282 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989003283 putative active site [active] 43989003284 heme pocket [chemical binding]; other site 43989003285 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 43989003286 GAF domain; Region: GAF; pfam01590 43989003287 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 43989003288 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989003289 dimer interface [polypeptide binding]; other site 43989003290 phosphorylation site [posttranslational modification] 43989003291 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989003292 ATP binding site [chemical binding]; other site 43989003293 Mg2+ binding site [ion binding]; other site 43989003294 G-X-G motif; other site 43989003295 Response regulator receiver domain; Region: Response_reg; pfam00072 43989003296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989003297 active site 43989003298 phosphorylation site [posttranslational modification] 43989003299 intermolecular recognition site; other site 43989003300 dimerization interface [polypeptide binding]; other site 43989003301 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989003302 dimer interface [polypeptide binding]; other site 43989003303 phosphorylation site [posttranslational modification] 43989003304 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989003305 ATP binding site [chemical binding]; other site 43989003306 Mg2+ binding site [ion binding]; other site 43989003307 G-X-G motif; other site 43989003308 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 43989003309 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 43989003310 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 43989003311 Ion channel; Region: Ion_trans_2; pfam07885 43989003312 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 43989003313 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 43989003314 Protein of unknown function (DUF4090); Region: DUF4090; pfam13319 43989003315 Predicted transcriptional regulator [Transcription]; Region: COG2378 43989003316 HTH domain; Region: HTH_11; pfam08279 43989003317 WYL domain; Region: WYL; pfam13280 43989003318 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl09782 43989003319 CRISPR-associated endonuclease Cas3-HD; Region: cas3_HD; TIGR01596 43989003320 DEAD-like helicases superfamily; Region: DEXDc; smart00487 43989003321 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 43989003322 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl11892 43989003323 CRISPR/Cas system-associated protein Cas8c' Region: Cas8c'_I-D; cl11893 43989003324 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 43989003325 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 43989003326 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 43989003327 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 43989003328 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 43989003329 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 43989003330 Domain of unknown function DUF29; Region: DUF29; pfam01724 43989003331 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 43989003332 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 43989003333 homotetramer interface [polypeptide binding]; other site 43989003334 FMN binding site [chemical binding]; other site 43989003335 homodimer contacts [polypeptide binding]; other site 43989003336 putative active site [active] 43989003337 putative substrate binding site [chemical binding]; other site 43989003338 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 43989003339 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 43989003340 active site 43989003341 catalytic site [active] 43989003342 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 43989003343 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 43989003344 Ligand Binding Site [chemical binding]; other site 43989003345 Sec-independent translocase component C; Provisional; Region: tatC; CHL00182 43989003346 PAS domain S-box; Region: sensory_box; TIGR00229 43989003347 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989003348 putative active site [active] 43989003349 heme pocket [chemical binding]; other site 43989003350 GAF domain; Region: GAF_3; pfam13492 43989003351 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 43989003352 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 43989003353 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 43989003354 metal binding site [ion binding]; metal-binding site 43989003355 active site 43989003356 I-site; other site 43989003357 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 43989003358 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 43989003359 RuvA N terminal domain; Region: RuvA_N; pfam01330 43989003360 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 43989003361 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 43989003362 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 43989003363 dimerization interface [polypeptide binding]; other site 43989003364 ATP binding site [chemical binding]; other site 43989003365 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 43989003366 dimerization interface [polypeptide binding]; other site 43989003367 ATP binding site [chemical binding]; other site 43989003368 amidophosphoribosyltransferase; Provisional; Region: PRK07349 43989003369 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 43989003370 active site 43989003371 tetramer interface [polypeptide binding]; other site 43989003372 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 43989003373 active site 43989003374 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 43989003375 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 43989003376 cofactor binding site; other site 43989003377 DNA binding site [nucleotide binding] 43989003378 substrate interaction site [chemical binding]; other site 43989003379 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 43989003380 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 43989003381 [4Fe-4S] binding site [ion binding]; other site 43989003382 molybdopterin cofactor binding site; other site 43989003383 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 43989003384 molybdopterin cofactor binding site; other site 43989003385 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 43989003386 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989003387 putative active site [active] 43989003388 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 43989003389 YcfA-like protein; Region: YcfA; pfam07927 43989003390 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 43989003391 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 43989003392 putative substrate translocation pore; other site 43989003393 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 43989003394 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 43989003395 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 43989003396 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 43989003397 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 43989003398 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 43989003399 inhibitor binding site; inhibition site 43989003400 catalytic motif [active] 43989003401 Catalytic residue [active] 43989003402 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 43989003403 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 43989003404 Walker A motif; other site 43989003405 ATP binding site [chemical binding]; other site 43989003406 Walker B motif; other site 43989003407 arginine finger; other site 43989003408 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 43989003409 putative active site [active] 43989003410 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 43989003411 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 43989003412 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 43989003413 P loop; other site 43989003414 Nucleotide binding site [chemical binding]; other site 43989003415 DTAP/Switch II; other site 43989003416 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 43989003417 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 43989003418 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 43989003419 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 43989003420 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 43989003421 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 43989003422 Walker A/P-loop; other site 43989003423 ATP binding site [chemical binding]; other site 43989003424 Q-loop/lid; other site 43989003425 ABC transporter signature motif; other site 43989003426 Walker B; other site 43989003427 D-loop; other site 43989003428 H-loop/switch region; other site 43989003429 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 43989003430 extended (e) SDRs; Region: SDR_e; cd08946 43989003431 NAD(P) binding site [chemical binding]; other site 43989003432 active site 43989003433 substrate binding site [chemical binding]; other site 43989003434 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 43989003435 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 43989003436 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 43989003437 active site 43989003438 interdomain interaction site; other site 43989003439 putative metal-binding site [ion binding]; other site 43989003440 nucleotide binding site [chemical binding]; other site 43989003441 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 43989003442 domain I; other site 43989003443 phosphate binding site [ion binding]; other site 43989003444 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 43989003445 domain II; other site 43989003446 domain III; other site 43989003447 nucleotide binding site [chemical binding]; other site 43989003448 DNA binding groove [nucleotide binding] 43989003449 catalytic site [active] 43989003450 domain IV; other site 43989003451 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 43989003452 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 43989003453 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 43989003454 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 43989003455 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989003456 putative active site [active] 43989003457 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 43989003458 Catalytic domain of Protein Kinases; Region: PKc; cd00180 43989003459 active site 43989003460 ATP binding site [chemical binding]; other site 43989003461 substrate binding site [chemical binding]; other site 43989003462 activation loop (A-loop); other site 43989003463 GUN4-like; Region: GUN4; pfam05419 43989003464 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989003465 binding surface 43989003466 TPR repeat; Region: TPR_11; pfam13414 43989003467 TPR motif; other site 43989003468 TPR repeat; Region: TPR_11; pfam13414 43989003469 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 43989003470 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 43989003471 ABC-ATPase subunit interface; other site 43989003472 dimer interface [polypeptide binding]; other site 43989003473 putative PBP binding regions; other site 43989003474 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 43989003475 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 43989003476 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 43989003477 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 43989003478 metal binding site [ion binding]; metal-binding site 43989003479 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 43989003480 metal binding site [ion binding]; metal-binding site 43989003481 active site 43989003482 I-site; other site 43989003483 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 43989003484 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 43989003485 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 43989003486 NAD(P) binding site [chemical binding]; other site 43989003487 active site 43989003488 Predicted permeases [General function prediction only]; Region: COG0795 43989003489 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 43989003490 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 43989003491 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 43989003492 Cl- selectivity filter; other site 43989003493 Cl- binding residues [ion binding]; other site 43989003494 pore gating glutamate residue; other site 43989003495 dimer interface [polypeptide binding]; other site 43989003496 H+/Cl- coupling transport residue; other site 43989003497 Ion channel; Region: Ion_trans_2; pfam07885 43989003498 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 43989003499 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 43989003500 Predicted periplasmic protein (DUF2092); Region: DUF2092; cl17607 43989003501 Uncharacterized conserved protein [Function unknown]; Region: COG5361 43989003502 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 43989003503 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 43989003504 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 43989003505 Sulfatase; Region: Sulfatase; pfam00884 43989003506 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 43989003507 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 43989003508 linker region; other site 43989003509 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 43989003510 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 43989003511 putative active site [active] 43989003512 putative metal binding site [ion binding]; other site 43989003513 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 43989003514 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 43989003515 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 43989003516 glutaminase active site [active] 43989003517 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 43989003518 dimer interface [polypeptide binding]; other site 43989003519 active site 43989003520 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 43989003521 dimer interface [polypeptide binding]; other site 43989003522 active site 43989003523 C factor cell-cell signaling protein; Provisional; Region: PRK09009 43989003524 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 43989003525 NADP binding site [chemical binding]; other site 43989003526 homodimer interface [polypeptide binding]; other site 43989003527 active site 43989003528 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 43989003529 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 43989003530 minor groove reading motif; other site 43989003531 helix-hairpin-helix signature motif; other site 43989003532 substrate binding pocket [chemical binding]; other site 43989003533 active site 43989003534 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 43989003535 cell division protein; Validated; Region: ftsH; CHL00176 43989003536 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 43989003537 Walker A motif; other site 43989003538 ATP binding site [chemical binding]; other site 43989003539 Walker B motif; other site 43989003540 arginine finger; other site 43989003541 Peptidase family M41; Region: Peptidase_M41; pfam01434 43989003542 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 43989003543 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989003544 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989003545 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989003546 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 43989003547 ATP-grasp domain; Region: ATP-grasp; pfam02222 43989003548 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 43989003549 nucleoside/Zn binding site; other site 43989003550 dimer interface [polypeptide binding]; other site 43989003551 catalytic motif [active] 43989003552 EamA-like transporter family; Region: EamA; cl17759 43989003553 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 43989003554 IHF dimer interface [polypeptide binding]; other site 43989003555 IHF - DNA interface [nucleotide binding]; other site 43989003556 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 43989003557 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 43989003558 GAF domain; Region: GAF; pfam01590 43989003559 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 43989003560 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989003561 dimer interface [polypeptide binding]; other site 43989003562 phosphorylation site [posttranslational modification] 43989003563 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 43989003564 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 43989003565 Ligand binding site; other site 43989003566 Putative Catalytic site; other site 43989003567 DXD motif; other site 43989003568 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 43989003569 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 43989003570 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 43989003571 FeS/SAM binding site; other site 43989003572 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 43989003573 SnoaL-like domain; Region: SnoaL_2; pfam12680 43989003574 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 43989003575 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 43989003576 active site 43989003577 homodimer interface [polypeptide binding]; other site 43989003578 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 43989003579 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 43989003580 Ligand Binding Site [chemical binding]; other site 43989003581 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 43989003582 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 43989003583 active site 43989003584 catalytic tetrad [active] 43989003585 Lipoxygenase; Region: Lipoxygenase; pfam00305 43989003586 photosystem I reaction center subunit IX; Provisional; Region: PRK02733 43989003587 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 43989003588 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 43989003589 Domain of unknown function DUF21; Region: DUF21; pfam01595 43989003590 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 43989003591 Transporter associated domain; Region: CorC_HlyC; smart01091 43989003592 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 43989003593 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 43989003594 catalytic triad [active] 43989003595 GTPase RsgA; Reviewed; Region: PRK12289 43989003596 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 43989003597 RNA binding site [nucleotide binding]; other site 43989003598 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 43989003599 GTPase/Zn-binding domain interface [polypeptide binding]; other site 43989003600 GTP/Mg2+ binding site [chemical binding]; other site 43989003601 G4 box; other site 43989003602 G5 box; other site 43989003603 G1 box; other site 43989003604 Switch I region; other site 43989003605 G2 box; other site 43989003606 G3 box; other site 43989003607 Switch II region; other site 43989003608 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 43989003609 CPxP motif; other site 43989003610 chaperone protein DnaJ; Provisional; Region: PRK14293 43989003611 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 43989003612 HSP70 interaction site [polypeptide binding]; other site 43989003613 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 43989003614 Zn binding sites [ion binding]; other site 43989003615 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 43989003616 dimer interface [polypeptide binding]; other site 43989003617 Tetratricopeptide repeat; Region: TPR_12; pfam13424 43989003618 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989003619 binding surface 43989003620 TPR motif; other site 43989003621 photosystem II reaction center protein J; Provisional; Region: PRK02565 43989003622 photosystem II reaction center L; Provisional; Region: psbL; PRK00753 43989003623 cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561 43989003624 cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557 43989003625 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283 43989003626 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284 43989003627 Ycf48-like protein; Provisional; Region: PRK13684 43989003628 Rubredoxin [Energy production and conversion]; Region: COG1773 43989003629 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 43989003630 iron binding site [ion binding]; other site 43989003631 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 43989003632 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 43989003633 putative active site [active] 43989003634 metal binding site [ion binding]; metal-binding site 43989003635 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 43989003636 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 43989003637 dimer interface [polypeptide binding]; other site 43989003638 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 43989003639 active site 43989003640 Fe binding site [ion binding]; other site 43989003641 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 43989003642 flavodoxin FldA; Validated; Region: PRK09267 43989003643 cell division protein FtsZ; Validated; Region: PRK09330 43989003644 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 43989003645 nucleotide binding site [chemical binding]; other site 43989003646 SulA interaction site; other site 43989003647 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 43989003648 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 43989003649 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 43989003650 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 43989003651 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 43989003652 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 43989003653 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 43989003654 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 43989003655 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 43989003656 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 43989003657 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 43989003658 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 43989003659 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 43989003660 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 43989003661 dimer interface [polypeptide binding]; other site 43989003662 motif 1; other site 43989003663 active site 43989003664 motif 2; other site 43989003665 motif 3; other site 43989003666 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 43989003667 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 43989003668 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 43989003669 putative tRNA-binding site [nucleotide binding]; other site 43989003670 B3/4 domain; Region: B3_4; pfam03483 43989003671 tRNA synthetase B5 domain; Region: B5; smart00874 43989003672 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 43989003673 dimer interface [polypeptide binding]; other site 43989003674 motif 1; other site 43989003675 motif 3; other site 43989003676 motif 2; other site 43989003677 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 43989003678 YciI-like protein; Reviewed; Region: PRK12864 43989003679 Homeodomain-like domain; Region: HTH_23; cl17451 43989003680 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989003681 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 43989003682 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 43989003683 HflX GTPase family; Region: HflX; cd01878 43989003684 G1 box; other site 43989003685 GTP/Mg2+ binding site [chemical binding]; other site 43989003686 Switch I region; other site 43989003687 G2 box; other site 43989003688 G3 box; other site 43989003689 Switch II region; other site 43989003690 G4 box; other site 43989003691 G5 box; other site 43989003692 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 43989003693 Protein of unknown function (DUF561); Region: DUF561; pfam04481 43989003694 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 43989003695 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 43989003696 active site 43989003697 trimer interface [polypeptide binding]; other site 43989003698 allosteric site; other site 43989003699 active site lid [active] 43989003700 hexamer (dimer of trimers) interface [polypeptide binding]; other site 43989003701 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 43989003702 Major Facilitator Superfamily; Region: MFS_1; pfam07690 43989003703 putative substrate translocation pore; other site 43989003704 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 43989003705 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 43989003706 RNA binding surface [nucleotide binding]; other site 43989003707 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 43989003708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 43989003709 TRAM domain; Region: TRAM; cl01282 43989003710 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 43989003711 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989003712 S-adenosylmethionine binding site [chemical binding]; other site 43989003713 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 43989003714 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 43989003715 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 43989003716 PsaD; Region: PsaD; pfam02531 43989003717 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 43989003718 oligomerisation interface [polypeptide binding]; other site 43989003719 mobile loop; other site 43989003720 roof hairpin; other site 43989003721 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 43989003722 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 43989003723 ring oligomerisation interface [polypeptide binding]; other site 43989003724 ATP/Mg binding site [chemical binding]; other site 43989003725 stacking interactions; other site 43989003726 hinge regions; other site 43989003727 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 43989003728 core domain interface [polypeptide binding]; other site 43989003729 delta subunit interface [polypeptide binding]; other site 43989003730 epsilon subunit interface [polypeptide binding]; other site 43989003731 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 43989003732 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 43989003733 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 43989003734 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 43989003735 catalytic residue [active] 43989003736 putative FPP diphosphate binding site; other site 43989003737 putative FPP binding hydrophobic cleft; other site 43989003738 dimer interface [polypeptide binding]; other site 43989003739 putative IPP diphosphate binding site; other site 43989003740 TIGR00159 family protein; Region: TIGR00159 43989003741 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 43989003742 diaminopimelate decarboxylase; Region: lysA; TIGR01048 43989003743 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 43989003744 active site 43989003745 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 43989003746 substrate binding site [chemical binding]; other site 43989003747 catalytic residues [active] 43989003748 dimer interface [polypeptide binding]; other site 43989003749 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 43989003750 SNF2 Helicase protein; Region: DUF3670; pfam12419 43989003751 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 43989003752 ATP binding site [chemical binding]; other site 43989003753 putative Mg++ binding site [ion binding]; other site 43989003754 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 43989003755 nucleotide binding region [chemical binding]; other site 43989003756 ATP-binding site [chemical binding]; other site 43989003757 ATP cone domain; Region: ATP-cone; pfam03477 43989003758 ribonucleoside-diphosphate reductase, alpha subunit; Region: NrdE_NrdA; TIGR02506 43989003759 Class I ribonucleotide reductase; Region: RNR_I; cd01679 43989003760 active site 43989003761 dimer interface [polypeptide binding]; other site 43989003762 catalytic residues [active] 43989003763 effector binding site; other site 43989003764 R2 peptide binding site; other site 43989003765 chaperone protein DnaJ; Provisional; Region: PRK14299 43989003766 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 43989003767 HSP70 interaction site [polypeptide binding]; other site 43989003768 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 43989003769 dimer interface [polypeptide binding]; other site 43989003770 molecular chaperone DnaK; Provisional; Region: PRK13410 43989003771 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 43989003772 nucleotide binding site [chemical binding]; other site 43989003773 NEF interaction site [polypeptide binding]; other site 43989003774 SBD interface [polypeptide binding]; other site 43989003775 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 43989003776 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 43989003777 intersubunit interface [polypeptide binding]; other site 43989003778 active site 43989003779 zinc binding site [ion binding]; other site 43989003780 Na+ binding site [ion binding]; other site 43989003781 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 43989003782 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 43989003783 Mg++ binding site [ion binding]; other site 43989003784 putative catalytic motif [active] 43989003785 substrate binding site [chemical binding]; other site 43989003786 Creatinine amidohydrolase; Region: Creatininase; pfam02633 43989003787 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 43989003788 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 43989003789 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 43989003790 G-X-X-G motif; other site 43989003791 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 43989003792 RxxxH motif; other site 43989003793 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654 43989003794 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 43989003795 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 43989003796 Bacterial PH domain; Region: DUF304; pfam03703 43989003797 ribonuclease P; Reviewed; Region: rnpA; PRK03031 43989003798 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 43989003799 Family of unknown function (DUF490); Region: DUF490; pfam04357 43989003800 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 43989003801 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 43989003802 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 43989003803 substrate binding pocket [chemical binding]; other site 43989003804 membrane-bound complex binding site; other site 43989003805 hinge residues; other site 43989003806 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 43989003807 Domain of unknown function DUF20; Region: UPF0118; pfam01594 43989003808 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 43989003809 C-terminal peptidase (prc); Region: prc; TIGR00225 43989003810 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 43989003811 protein binding site [polypeptide binding]; other site 43989003812 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 43989003813 Catalytic dyad [active] 43989003814 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 43989003815 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 43989003816 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 43989003817 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 43989003818 putative active site [active] 43989003819 transaldolase; Provisional; Region: PRK03903 43989003820 catalytic residue [active] 43989003821 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 43989003822 aromatic arch; other site 43989003823 DCoH dimer interaction site [polypeptide binding]; other site 43989003824 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 43989003825 DCoH tetramer interaction site [polypeptide binding]; other site 43989003826 substrate binding site [chemical binding]; other site 43989003827 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 43989003828 Ligand Binding Site [chemical binding]; other site 43989003829 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 43989003830 shikimate kinase; Reviewed; Region: aroK; PRK00131 43989003831 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 43989003832 ADP binding site [chemical binding]; other site 43989003833 magnesium binding site [ion binding]; other site 43989003834 putative shikimate binding site; other site 43989003835 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 43989003836 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 43989003837 Qi binding site; other site 43989003838 intrachain domain interface; other site 43989003839 interchain domain interface [polypeptide binding]; other site 43989003840 heme bH binding site [chemical binding]; other site 43989003841 heme bL binding site [chemical binding]; other site 43989003842 Qo binding site; other site 43989003843 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 43989003844 interchain domain interface [polypeptide binding]; other site 43989003845 intrachain domain interface; other site 43989003846 Qi binding site; other site 43989003847 Qo binding site; other site 43989003848 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 43989003849 DctM-like transporters; Region: DctM; pfam06808 43989003850 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 43989003851 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 43989003852 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 43989003853 active site residue [active] 43989003854 ribosomal protein L21; Region: rpl21; CHL00075 43989003855 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 43989003856 Mannosyltransferase putative; Region: Mannosyl_trans3; pfam11051 43989003857 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 43989003858 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 43989003859 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 43989003860 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 43989003861 dimerization interface [polypeptide binding]; other site 43989003862 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 43989003863 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 43989003864 metal binding site [ion binding]; metal-binding site 43989003865 active site 43989003866 I-site; other site 43989003867 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 43989003868 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 43989003869 active site 43989003870 catalytic residues [active] 43989003871 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 43989003872 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 43989003873 TPP-binding site; other site 43989003874 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 43989003875 PYR/PP interface [polypeptide binding]; other site 43989003876 dimer interface [polypeptide binding]; other site 43989003877 TPP binding site [chemical binding]; other site 43989003878 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 43989003879 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 43989003880 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 43989003881 Na binding site [ion binding]; other site 43989003882 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989003883 putative active site [active] 43989003884 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989003885 putative active site [active] 43989003886 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 43989003887 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 43989003888 inhibitor-cofactor binding pocket; inhibition site 43989003889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 43989003890 catalytic residue [active] 43989003891 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 43989003892 Horizontally Transferred TransMembrane Domain; Region: HTTM; smart00752 43989003893 Protein of unknown function, DUF393; Region: DUF393; cl01136 43989003894 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 43989003895 GAF domain; Region: GAF; pfam01590 43989003896 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 43989003897 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 43989003898 metal binding site [ion binding]; metal-binding site 43989003899 active site 43989003900 I-site; other site 43989003901 Response regulator receiver domain; Region: Response_reg; pfam00072 43989003902 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989003903 active site 43989003904 phosphorylation site [posttranslational modification] 43989003905 intermolecular recognition site; other site 43989003906 dimerization interface [polypeptide binding]; other site 43989003907 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 43989003908 GAF domain; Region: GAF; pfam01590 43989003909 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 43989003910 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 43989003911 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 43989003912 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 43989003913 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 43989003914 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 43989003915 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 43989003916 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 43989003917 PAS domain; Region: PAS; smart00091 43989003918 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 43989003919 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989003920 dimer interface [polypeptide binding]; other site 43989003921 phosphorylation site [posttranslational modification] 43989003922 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989003923 ATP binding site [chemical binding]; other site 43989003924 Mg2+ binding site [ion binding]; other site 43989003925 G-X-G motif; other site 43989003926 acyl-CoA synthetase; Validated; Region: PRK05850 43989003927 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 43989003928 acyl-activating enzyme (AAE) consensus motif; other site 43989003929 active site 43989003930 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 43989003931 phosphodiesterase; Provisional; Region: PRK12704 43989003932 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 43989003933 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 43989003934 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 43989003935 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 43989003936 ligand binding site [chemical binding]; other site 43989003937 flexible hinge region; other site 43989003938 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 43989003939 putative switch regulator; other site 43989003940 non-specific DNA interactions [nucleotide binding]; other site 43989003941 DNA binding site [nucleotide binding] 43989003942 sequence specific DNA binding site [nucleotide binding]; other site 43989003943 putative cAMP binding site [chemical binding]; other site 43989003944 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989003945 putative active site [active] 43989003946 PUCC protein; Region: PUCC; pfam03209 43989003947 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 43989003948 Fe-S cluster binding site [ion binding]; other site 43989003949 active site 43989003950 Predicted integral membrane protein [Function unknown]; Region: COG5617 43989003951 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 43989003952 HSP70 interaction site [polypeptide binding]; other site 43989003953 acyl-ACP reductase; Provisional; Region: PRK14982 43989003954 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 43989003955 NAD(P) binding pocket [chemical binding]; other site 43989003956 Predicted integral membrane protein [Function unknown]; Region: COG0392 43989003957 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 43989003958 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 43989003959 GIY-YIG motif/motif A; other site 43989003960 active site 43989003961 catalytic site [active] 43989003962 putative DNA binding site [nucleotide binding]; other site 43989003963 metal binding site [ion binding]; metal-binding site 43989003964 UvrB/uvrC motif; Region: UVR; pfam02151 43989003965 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 43989003966 Helix-hairpin-helix motif; Region: HHH; pfam00633 43989003967 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 43989003968 CHRD domain; Region: CHRD; pfam07452 43989003969 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 43989003970 Protein of unknown function (DUF3254); Region: DUF3254; pfam11630 43989003971 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 43989003972 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 43989003973 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476 43989003974 similar to hypothetical protein 43989003975 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 43989003976 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 43989003977 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 43989003978 threonine synthase; Reviewed; Region: PRK06721 43989003979 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 43989003980 homodimer interface [polypeptide binding]; other site 43989003981 pyridoxal 5'-phosphate binding site [chemical binding]; other site 43989003982 catalytic residue [active] 43989003983 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 43989003984 trehalose synthase; Region: treS_nterm; TIGR02456 43989003985 active site 43989003986 catalytic site [active] 43989003987 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 43989003988 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 43989003989 active site 43989003990 catalytic site [active] 43989003991 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 43989003992 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 43989003993 active site 43989003994 catalytic site [active] 43989003995 Domain of unknown function DUF29; Region: DUF29; pfam01724 43989003996 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 43989003997 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 43989003998 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 43989003999 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 43989004000 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 43989004001 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 43989004002 DsrE/DsrF-like family; Region: DrsE; cl00672 43989004003 DsrE/DsrF-like family; Region: DrsE; cl00672 43989004004 DsrE/DsrF-like family; Region: DrsE; pfam02635 43989004005 acyl-CoA synthetase; Validated; Region: PRK05850 43989004006 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 43989004007 acyl-activating enzyme (AAE) consensus motif; other site 43989004008 active site 43989004009 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 43989004010 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 43989004011 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 43989004012 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 43989004013 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989004014 dimer interface [polypeptide binding]; other site 43989004015 phosphorylation site [posttranslational modification] 43989004016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989004017 ATP binding site [chemical binding]; other site 43989004018 Mg2+ binding site [ion binding]; other site 43989004019 G-X-G motif; other site 43989004020 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 43989004021 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 43989004022 AAA domain; Region: AAA_31; pfam13614 43989004023 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 43989004024 BON domain; Region: BON; cl02771 43989004025 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 43989004026 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 43989004027 Walker A/P-loop; other site 43989004028 ATP binding site [chemical binding]; other site 43989004029 Q-loop/lid; other site 43989004030 ABC transporter signature motif; other site 43989004031 Walker B; other site 43989004032 D-loop; other site 43989004033 H-loop/switch region; other site 43989004034 ABC-2 type transporter; Region: ABC2_membrane; cl17235 43989004035 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 43989004036 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 43989004037 HSP70 interaction site [polypeptide binding]; other site 43989004038 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 43989004039 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 43989004040 dimer interface [polypeptide binding]; other site 43989004041 pyridoxal 5'-phosphate binding site [chemical binding]; other site 43989004042 catalytic residue [active] 43989004043 4-alpha-glucanotransferase; Provisional; Region: PRK14508 43989004044 FOG: WD40 repeat [General function prediction only]; Region: COG2319 43989004045 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 43989004046 structural tetrad; other site 43989004047 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 43989004048 EamA-like transporter family; Region: EamA; pfam00892 43989004049 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 43989004050 catalytic core [active] 43989004051 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 43989004052 NDF6 (NDH-dependent flow 6); Provisional; Region: PLN00180 43989004053 mechanosensitive channel MscS; Provisional; Region: PRK10334 43989004054 Conserved TM helix; Region: TM_helix; pfam05552 43989004055 Mechanosensitive ion channel; Region: MS_channel; pfam00924 43989004056 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 43989004057 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 43989004058 intersubunit interface [polypeptide binding]; other site 43989004059 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 43989004060 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 43989004061 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 43989004062 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 43989004063 ABC-ATPase subunit interface; other site 43989004064 dimer interface [polypeptide binding]; other site 43989004065 putative PBP binding regions; other site 43989004066 FOG: WD40 repeat [General function prediction only]; Region: COG2319 43989004067 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 43989004068 structural tetrad; other site 43989004069 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 43989004070 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 43989004071 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 43989004072 P-loop, Walker A motif; other site 43989004073 Base recognition motif; other site 43989004074 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 43989004075 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 43989004076 dimer interface [polypeptide binding]; other site 43989004077 active site 43989004078 aspartate-rich active site metal binding site; other site 43989004079 allosteric magnesium binding site [ion binding]; other site 43989004080 Schiff base residues; other site 43989004081 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 43989004082 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 43989004083 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 43989004084 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 43989004085 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 43989004086 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 43989004087 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 43989004088 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 43989004089 active site 43989004090 metal binding site [ion binding]; metal-binding site 43989004091 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 43989004092 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 43989004093 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 43989004094 active site 43989004095 dimer interface [polypeptide binding]; other site 43989004096 motif 1; other site 43989004097 motif 2; other site 43989004098 motif 3; other site 43989004099 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 43989004100 anticodon binding site; other site 43989004101 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 43989004102 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 43989004103 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 43989004104 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 43989004105 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 43989004106 ligand binding site [chemical binding]; other site 43989004107 flexible hinge region; other site 43989004108 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 43989004109 Walker A motif; other site 43989004110 ATP binding site [chemical binding]; other site 43989004111 Walker B motif; other site 43989004112 arginine finger; other site 43989004113 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 43989004114 4Fe-4S binding domain; Region: Fer4_5; pfam12801 43989004115 4Fe-4S binding domain; Region: Fer4_5; pfam12801 43989004116 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 43989004117 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 43989004118 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 43989004119 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 43989004120 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 43989004121 homodecamer interface [polypeptide binding]; other site 43989004122 GTP cyclohydrolase I; Provisional; Region: PLN03044 43989004123 active site 43989004124 putative catalytic site residues [active] 43989004125 zinc binding site [ion binding]; other site 43989004126 GTP-CH-I/GFRP interaction surface; other site 43989004127 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 43989004128 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 43989004129 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 43989004130 Walker A motif; other site 43989004131 ATP binding site [chemical binding]; other site 43989004132 Walker B motif; other site 43989004133 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 43989004134 YcfA-like protein; Region: YcfA; cl00752 43989004135 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 43989004136 F0F1 ATP synthase subunit B; Provisional; Region: PRK14474 43989004137 alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321 43989004138 alternate F1F0 ATPase, F0 subunit C; Region: alt_F1F0_F0_C; TIGR03322 43989004139 ATP synthase A chain; Region: ATP-synt_A; cl00413 43989004140 N-ATPase, AtpR subunit; Region: AtpR; pfam12966 43989004141 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 43989004142 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 43989004143 F0F1 ATP synthase subunit epsilon; Validated; Region: PRK06228 43989004144 gamma subunit interface [polypeptide binding]; other site 43989004145 epsilon subunit interface [polypeptide binding]; other site 43989004146 LBP interface [polypeptide binding]; other site 43989004147 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 43989004148 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 43989004149 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 43989004150 alpha subunit interaction interface [polypeptide binding]; other site 43989004151 Walker A motif; other site 43989004152 ATP binding site [chemical binding]; other site 43989004153 Walker B motif; other site 43989004154 inhibitor binding site; inhibition site 43989004155 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 43989004156 S-layer homology domain; Region: SLH; pfam00395 43989004157 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 43989004158 active site 43989004159 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 43989004160 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 43989004161 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989004162 putative active site [active] 43989004163 heme pocket [chemical binding]; other site 43989004164 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989004165 putative active site [active] 43989004166 heme pocket [chemical binding]; other site 43989004167 PAS fold; Region: PAS_4; pfam08448 43989004168 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989004169 putative active site [active] 43989004170 heme pocket [chemical binding]; other site 43989004171 PAS domain S-box; Region: sensory_box; TIGR00229 43989004172 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989004173 putative active site [active] 43989004174 heme pocket [chemical binding]; other site 43989004175 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989004176 PAS fold; Region: PAS_3; pfam08447 43989004177 putative active site [active] 43989004178 heme pocket [chemical binding]; other site 43989004179 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 43989004180 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989004181 putative active site [active] 43989004182 heme pocket [chemical binding]; other site 43989004183 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989004184 dimer interface [polypeptide binding]; other site 43989004185 phosphorylation site [posttranslational modification] 43989004186 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989004187 ATP binding site [chemical binding]; other site 43989004188 Mg2+ binding site [ion binding]; other site 43989004189 G-X-G motif; other site 43989004190 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989004191 Response regulator receiver domain; Region: Response_reg; pfam00072 43989004192 active site 43989004193 phosphorylation site [posttranslational modification] 43989004194 intermolecular recognition site; other site 43989004195 dimerization interface [polypeptide binding]; other site 43989004196 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 43989004197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989004198 active site 43989004199 phosphorylation site [posttranslational modification] 43989004200 intermolecular recognition site; other site 43989004201 dimerization interface [polypeptide binding]; other site 43989004202 PAS domain S-box; Region: sensory_box; TIGR00229 43989004203 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989004204 putative active site [active] 43989004205 heme pocket [chemical binding]; other site 43989004206 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 43989004207 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 43989004208 metal binding site [ion binding]; metal-binding site 43989004209 active site 43989004210 I-site; other site 43989004211 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 43989004212 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 43989004213 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 43989004214 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 43989004215 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 43989004216 active site 43989004217 metal binding site [ion binding]; metal-binding site 43989004218 Protein of unknown function (DUF2396); Region: DUF2396; pfam09654 43989004219 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 43989004220 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 43989004221 trimer interface [polypeptide binding]; other site 43989004222 putative metal binding site [ion binding]; other site 43989004223 Photosystem II protein Y (PsbY); Region: PsbY; cl05675 43989004224 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 43989004225 active site 43989004226 dimer interface [polypeptide binding]; other site 43989004227 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 43989004228 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 43989004229 Walker A/P-loop; other site 43989004230 ATP binding site [chemical binding]; other site 43989004231 Q-loop/lid; other site 43989004232 ABC transporter signature motif; other site 43989004233 Walker B; other site 43989004234 D-loop; other site 43989004235 H-loop/switch region; other site 43989004236 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 43989004237 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 43989004238 Walker A/P-loop; other site 43989004239 ATP binding site [chemical binding]; other site 43989004240 Q-loop/lid; other site 43989004241 ABC transporter signature motif; other site 43989004242 Walker B; other site 43989004243 D-loop; other site 43989004244 H-loop/switch region; other site 43989004245 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 43989004246 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 43989004247 carotene isomerase; Region: carot_isom; TIGR02730 43989004248 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 43989004249 hydroxyglutarate oxidase; Provisional; Region: PRK11728 43989004250 GAF domain; Region: GAF; pfam01590 43989004251 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 43989004252 Protein of unknown function (DUF3160); Region: DUF3160; pfam11369 43989004253 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989004254 ATP binding site [chemical binding]; other site 43989004255 Mg2+ binding site [ion binding]; other site 43989004256 G-X-G motif; other site 43989004257 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 43989004258 ABC1 family; Region: ABC1; cl17513 43989004259 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 43989004260 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 43989004261 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 43989004262 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 43989004263 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 43989004264 active site 43989004265 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 43989004266 catalytic core [active] 43989004267 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 43989004268 light-harvesting-like protein 3; Provisional; Region: PLN00014 43989004269 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 43989004270 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989004271 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989004272 Uncharacterized protein family UPF0546; Region: UPF0546; pfam10639 43989004273 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 43989004274 homotrimer interaction site [polypeptide binding]; other site 43989004275 putative active site [active] 43989004276 Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539 43989004277 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 43989004278 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 43989004279 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 43989004280 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 43989004281 P-loop; other site 43989004282 Magnesium ion binding site [ion binding]; other site 43989004283 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 43989004284 Magnesium ion binding site [ion binding]; other site 43989004285 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989004286 TPR motif; other site 43989004287 Tetratricopeptide repeat; Region: TPR_16; pfam13432 43989004288 binding surface 43989004289 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 43989004290 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 43989004291 GAF domain; Region: GAF; pfam01590 43989004292 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 43989004293 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 43989004294 HD domain; Region: HD_5; pfam13487 43989004295 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989004296 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 43989004297 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989004298 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989004299 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989004300 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 43989004301 N2,N2-dimethylguanosine tRNA methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TRM1; COG1867 43989004302 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 43989004303 Catalytic domain of Protein Kinases; Region: PKc; cd00180 43989004304 active site 43989004305 ATP binding site [chemical binding]; other site 43989004306 substrate binding site [chemical binding]; other site 43989004307 activation loop (A-loop); other site 43989004308 DNA primase, catalytic core; Region: dnaG; TIGR01391 43989004309 CHC2 zinc finger; Region: zf-CHC2; pfam01807 43989004310 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 43989004311 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 43989004312 active site 43989004313 metal binding site [ion binding]; metal-binding site 43989004314 interdomain interaction site; other site 43989004315 Ion channel; Region: Ion_trans_2; pfam07885 43989004316 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 43989004317 TrkA-N domain; Region: TrkA_N; pfam02254 43989004318 TrkA-C domain; Region: TrkA_C; pfam02080 43989004319 Uncharacterized conserved protein [Function unknown]; Region: COG1262 43989004320 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 43989004321 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 43989004322 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 43989004323 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 43989004324 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 43989004325 motif II; other site 43989004326 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 43989004327 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 43989004328 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 43989004329 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 43989004330 Protein of unknown function (DUF3727); Region: DUF3727; pfam12527 43989004331 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 43989004332 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 43989004333 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 43989004334 Type II secretory pathway, component HofQ [Intracellular trafficking and secretion]; Region: HofQ; COG4796 43989004335 Secretin and TonB N terminus short domain; Region: STN; pfam07660 43989004336 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 43989004337 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 43989004338 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 43989004339 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 43989004340 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 43989004341 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 43989004342 dimer interface [polypeptide binding]; other site 43989004343 active site 43989004344 CoA binding pocket [chemical binding]; other site 43989004345 putative phosphate acyltransferase; Provisional; Region: PRK05331 43989004346 methionine aminopeptidase; Provisional; Region: PRK08671 43989004347 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 43989004348 active site 43989004349 chaperone protein DnaJ; Provisional; Region: PRK14299 43989004350 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 43989004351 HSP70 interaction site [polypeptide binding]; other site 43989004352 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 43989004353 substrate binding site [polypeptide binding]; other site 43989004354 dimer interface [polypeptide binding]; other site 43989004355 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 43989004356 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 43989004357 substrate binding site [chemical binding]; other site 43989004358 catalytic Zn binding site [ion binding]; other site 43989004359 NAD binding site [chemical binding]; other site 43989004360 structural Zn binding site [ion binding]; other site 43989004361 dimer interface [polypeptide binding]; other site 43989004362 PQQ-like domain; Region: PQQ_2; pfam13360 43989004363 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 43989004364 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 43989004365 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989004366 putative active site [active] 43989004367 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 43989004368 active site 43989004369 NTP binding site [chemical binding]; other site 43989004370 metal binding triad [ion binding]; metal-binding site 43989004371 antibiotic binding site [chemical binding]; other site 43989004372 Protein of unknown function DUF86; Region: DUF86; cl01031 43989004373 Proline dehydrogenase; Region: Pro_dh; pfam01619 43989004374 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 43989004375 delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; Region: D1pyr5carbox2; TIGR01237 43989004376 Glutamate binding site [chemical binding]; other site 43989004377 homodimer interface [polypeptide binding]; other site 43989004378 NAD binding site [chemical binding]; other site 43989004379 catalytic residues [active] 43989004380 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 43989004381 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 43989004382 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 43989004383 active site 43989004384 NTP binding site [chemical binding]; other site 43989004385 nucleic acid binding site [nucleotide binding]; other site 43989004386 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 43989004387 MPT binding site; other site 43989004388 trimer interface [polypeptide binding]; other site 43989004389 photosystem II reaction center protein Psb28; Provisional; Region: PRK13612 43989004390 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 43989004391 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 43989004392 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 43989004393 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 43989004394 putative ligand binding site [chemical binding]; other site 43989004395 putative NAD binding site [chemical binding]; other site 43989004396 catalytic site [active] 43989004397 maltose O-acetyltransferase; Provisional; Region: PRK10092 43989004398 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 43989004399 active site 43989004400 substrate binding site [chemical binding]; other site 43989004401 trimer interface [polypeptide binding]; other site 43989004402 CoA binding site [chemical binding]; other site 43989004403 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 43989004404 homodimer interface [polypeptide binding]; other site 43989004405 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 43989004406 active site pocket [active] 43989004407 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 43989004408 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 43989004409 domain interfaces; other site 43989004410 active site 43989004411 O-succinylbenzoic acid--CoA ligase; Reviewed; Region: PRK07445 43989004412 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 43989004413 acyl-activating enzyme (AAE) consensus motif; other site 43989004414 putative AMP binding site [chemical binding]; other site 43989004415 putative active site [active] 43989004416 putative CoA binding site [chemical binding]; other site 43989004417 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 43989004418 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 43989004419 catalytic loop [active] 43989004420 iron binding site [ion binding]; other site 43989004421 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 43989004422 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 43989004423 catalytic loop [active] 43989004424 iron binding site [ion binding]; other site 43989004425 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 43989004426 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 43989004427 Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354 43989004428 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 43989004429 Protein of unknown function, DUF608; Region: DUF608; pfam04685 43989004430 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 43989004431 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 43989004432 substrate binding site [chemical binding]; other site 43989004433 ATP binding site [chemical binding]; other site 43989004434 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 43989004435 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 43989004436 ligand binding site [chemical binding]; other site 43989004437 flexible hinge region; other site 43989004438 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 43989004439 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 43989004440 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 43989004441 PDZ domain associated with archaeal and bacterial M61 glycyl-aminopeptidases. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to...; Region: PDZ_glycyl_aminopeptidase; cd00990 43989004442 protein binding site [polypeptide binding]; other site 43989004443 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 43989004444 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 43989004445 homodimer interface [polypeptide binding]; other site 43989004446 substrate-cofactor binding pocket; other site 43989004447 catalytic residue [active] 43989004448 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 43989004449 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 43989004450 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 43989004451 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 43989004452 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 43989004453 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 43989004454 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 43989004455 active site 43989004456 SAM binding site [chemical binding]; other site 43989004457 homodimer interface [polypeptide binding]; other site 43989004458 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 43989004459 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 43989004460 active site 43989004461 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 43989004462 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 43989004463 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 43989004464 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 43989004465 putative RNA binding site [nucleotide binding]; other site 43989004466 Uncharacterized conserved protein [Function unknown]; Region: COG2928 43989004467 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 43989004468 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 43989004469 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 43989004470 Walker A/P-loop; other site 43989004471 ATP binding site [chemical binding]; other site 43989004472 Q-loop/lid; other site 43989004473 ABC transporter signature motif; other site 43989004474 Walker B; other site 43989004475 D-loop; other site 43989004476 H-loop/switch region; other site 43989004477 Uncharacterized subfamily of glycoside hydrolase family 57 (GH57); Region: GH57N_like_1; cd10798 43989004478 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 43989004479 active site 43989004480 catalytic site [active] 43989004481 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 43989004482 homodimer interface [polypeptide binding]; other site 43989004483 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 43989004484 active site pocket [active] 43989004485 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 43989004486 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989004487 active site 43989004488 phosphorylation site [posttranslational modification] 43989004489 intermolecular recognition site; other site 43989004490 dimerization interface [polypeptide binding]; other site 43989004491 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 43989004492 DNA binding site [nucleotide binding] 43989004493 Transcriptional regulator [Transcription]; Region: LytR; COG1316 43989004494 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 43989004495 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 43989004496 phosphoenolpyruvate synthase; Validated; Region: PRK06241 43989004497 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 43989004498 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 43989004499 Bacterial Ig-like domain; Region: Big_5; pfam13205 43989004500 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 43989004501 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 43989004502 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 43989004503 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 43989004504 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 43989004505 active site 43989004506 catalytic tetrad [active] 43989004507 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 43989004508 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 43989004509 active site 43989004510 homodimer interface [polypeptide binding]; other site 43989004511 catalytic site [active] 43989004512 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 43989004513 dimer interface [polypeptide binding]; other site 43989004514 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 43989004515 putative radical transfer pathway; other site 43989004516 diiron center [ion binding]; other site 43989004517 tyrosyl radical; other site 43989004518 Predicted permeases [General function prediction only]; Region: COG0679 43989004519 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 43989004520 putative FMN binding site [chemical binding]; other site 43989004521 cobalamin synthase; Reviewed; Region: cobS; PRK00235 43989004522 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 43989004523 stage V sporulation protein K; Region: spore_V_K; TIGR02881 43989004524 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 43989004525 Walker A motif; other site 43989004526 ATP binding site [chemical binding]; other site 43989004527 Walker B motif; other site 43989004528 arginine finger; other site 43989004529 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 43989004530 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 43989004531 stage V sporulation protein K; Region: spore_V_K; TIGR02881 43989004532 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 43989004533 Walker A motif; other site 43989004534 ATP binding site [chemical binding]; other site 43989004535 Walker B motif; other site 43989004536 arginine finger; other site 43989004537 GLTT repeat (6 copies); Region: GLTT; pfam01744 43989004538 30S ribosomal protein S1; Reviewed; Region: PRK07400 43989004539 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 43989004540 RNA binding site [nucleotide binding]; other site 43989004541 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 43989004542 RNA binding site [nucleotide binding]; other site 43989004543 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 43989004544 RNA binding site [nucleotide binding]; other site 43989004545 acyl-CoA synthetase; Validated; Region: PRK05850 43989004546 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 43989004547 acyl-activating enzyme (AAE) consensus motif; other site 43989004548 active site 43989004549 Circadian oscillating protein COP23; Region: COP23; pfam14218 43989004550 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 43989004551 Walker A/P-loop; other site 43989004552 ATP binding site [chemical binding]; other site 43989004553 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 43989004554 dimer interface [polypeptide binding]; other site 43989004555 active site 43989004556 Schiff base residues; other site 43989004557 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 43989004558 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 43989004559 molybdopterin cofactor binding site; other site 43989004560 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 43989004561 molybdopterin cofactor binding site; other site 43989004562 Predicted membrane protein [Function unknown]; Region: COG2323 43989004563 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 43989004564 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 43989004565 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 43989004566 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 43989004567 catalytic loop [active] 43989004568 iron binding site [ion binding]; other site 43989004569 Dynamin family; Region: Dynamin_N; pfam00350 43989004570 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 43989004571 G1 box; other site 43989004572 GTP/Mg2+ binding site [chemical binding]; other site 43989004573 Switch I region; other site 43989004574 G2 box; other site 43989004575 Switch II region; other site 43989004576 G3 box; other site 43989004577 G4 box; other site 43989004578 G5 box; other site 43989004579 Domain of unknown function (DUF697); Region: DUF697; pfam05128 43989004580 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 43989004581 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 43989004582 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 43989004583 DNA polymerase III subunit delta; Validated; Region: PRK07452 43989004584 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 43989004585 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 43989004586 Catalytic domain of Protein Kinases; Region: PKc; cd00180 43989004587 active site 43989004588 ATP binding site [chemical binding]; other site 43989004589 substrate binding site [chemical binding]; other site 43989004590 activation loop (A-loop); other site 43989004591 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 43989004592 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 43989004593 GatB domain; Region: GatB_Yqey; smart00845 43989004594 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 43989004595 Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; pfam10063 43989004596 Circadian oscillating protein COP23; Region: COP23; pfam14218 43989004597 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 43989004598 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 43989004599 G1 box; other site 43989004600 putative GEF interaction site [polypeptide binding]; other site 43989004601 GTP/Mg2+ binding site [chemical binding]; other site 43989004602 Switch I region; other site 43989004603 G2 box; other site 43989004604 G3 box; other site 43989004605 Switch II region; other site 43989004606 G4 box; other site 43989004607 G5 box; other site 43989004608 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 43989004609 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 43989004610 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12567 43989004611 hypothetical protein; Provisional; Region: PRK07377 43989004612 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334 43989004613 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234 43989004614 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 43989004615 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08389 43989004616 Predicted membrane protein [Function unknown]; Region: COG3431 43989004617 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 43989004618 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 43989004619 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 43989004620 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 43989004621 Sulfate transporter family; Region: Sulfate_transp; pfam00916 43989004622 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 43989004623 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 43989004624 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 43989004625 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 43989004626 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 43989004627 NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473 43989004628 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 43989004629 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989004630 dimer interface [polypeptide binding]; other site 43989004631 phosphorylation site [posttranslational modification] 43989004632 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989004633 ATP binding site [chemical binding]; other site 43989004634 Mg2+ binding site [ion binding]; other site 43989004635 G-X-G motif; other site 43989004636 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 43989004637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989004638 active site 43989004639 phosphorylation site [posttranslational modification] 43989004640 intermolecular recognition site; other site 43989004641 dimerization interface [polypeptide binding]; other site 43989004642 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 43989004643 DNA binding site [nucleotide binding] 43989004644 Homeodomain-like domain; Region: HTH_23; pfam13384 43989004645 Winged helix-turn helix; Region: HTH_29; pfam13551 43989004646 Homeodomain-like domain; Region: HTH_32; pfam13565 43989004647 DDE superfamily endonuclease; Region: DDE_3; pfam13358 43989004648 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 43989004649 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 43989004650 DNA binding residues [nucleotide binding] 43989004651 dimer interface [polypeptide binding]; other site 43989004652 metal binding site [ion binding]; metal-binding site 43989004653 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 43989004654 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 43989004655 metal-binding site [ion binding] 43989004656 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 43989004657 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 43989004658 motif II; other site 43989004659 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 43989004660 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 43989004661 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 43989004662 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 43989004663 YtkA-like; Region: YtkA; pfam13115 43989004664 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 43989004665 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 43989004666 HlyD family secretion protein; Region: HlyD_3; pfam13437 43989004667 YtkA-like; Region: YtkA; pfam13115 43989004668 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 43989004669 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 43989004670 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 43989004671 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 43989004672 Uncharacterized conserved protein [Function unknown]; Region: COG5464 43989004673 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 43989004674 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 43989004675 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 43989004676 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 43989004677 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 43989004678 Walker A/P-loop; other site 43989004679 ATP binding site [chemical binding]; other site 43989004680 Q-loop/lid; other site 43989004681 ABC transporter signature motif; other site 43989004682 Walker B; other site 43989004683 D-loop; other site 43989004684 H-loop/switch region; other site 43989004685 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 43989004686 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 43989004687 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 43989004688 active site 43989004689 substrate binding site [chemical binding]; other site 43989004690 FMN binding site [chemical binding]; other site 43989004691 putative catalytic residues [active] 43989004692 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 43989004693 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 43989004694 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 43989004695 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 43989004696 catalytic motif [active] 43989004697 Catalytic residue [active] 43989004698 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 43989004699 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 43989004700 motif 1; other site 43989004701 active site 43989004702 motif 2; other site 43989004703 motif 3; other site 43989004704 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 43989004705 DHHA1 domain; Region: DHHA1; pfam02272 43989004706 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 43989004707 active site 43989004708 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 43989004709 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989004710 active site 43989004711 phosphorylation site [posttranslational modification] 43989004712 intermolecular recognition site; other site 43989004713 dimerization interface [polypeptide binding]; other site 43989004714 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 43989004715 DNA binding site [nucleotide binding] 43989004716 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989004717 putative active site [active] 43989004718 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 43989004719 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 43989004720 Transposase [DNA replication, recombination, and repair]; Region: COG5433 43989004721 Transposase [DNA replication, recombination, and repair]; Region: COG5433 43989004722 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 43989004723 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 43989004724 tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057 43989004725 hypothetical protein; Provisional; Region: PRK04194 43989004726 Protein of unknown function DUF111; Region: DUF111; cl03398 43989004727 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 43989004728 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 43989004729 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989004730 dimer interface [polypeptide binding]; other site 43989004731 phosphorylation site [posttranslational modification] 43989004732 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989004733 ATP binding site [chemical binding]; other site 43989004734 Mg2+ binding site [ion binding]; other site 43989004735 G-X-G motif; other site 43989004736 Domain of unknown function DUF29; Region: DUF29; pfam01724 43989004737 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989004738 putative active site [active] 43989004739 This group of endopeptidases include HupW enzymes that are specific to the cyanobacterial hydrogenase and are involved in the C-terminal cleavage of the hydrogenase large subunit precursor protein. Cyanobacterial nickel-iron (NiFe)-hydrogenases are found...; Region: H2MP_Cyano-H2up; cd06063 43989004740 nickel binding site [ion binding]; other site 43989004741 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 43989004742 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 43989004743 pyridoxal 5'-phosphate binding site [chemical binding]; other site 43989004744 homodimer interface [polypeptide binding]; other site 43989004745 catalytic residue [active] 43989004746 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 43989004747 IHF dimer interface [polypeptide binding]; other site 43989004748 IHF - DNA interface [nucleotide binding]; other site 43989004749 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 43989004750 photosystem I subunit VII; Region: psaC; CHL00065 43989004751 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 43989004752 Conserved TM helix; Region: TM_helix; pfam05552 43989004753 Conserved TM helix; Region: TM_helix; pfam05552 43989004754 Conserved TM helix; Region: TM_helix; pfam05552 43989004755 adaptive-response sensory kinase; Validated; Region: PRK09303 43989004756 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 43989004757 tetramer interface [polypeptide binding]; other site 43989004758 dimer interface [polypeptide binding]; other site 43989004759 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989004760 dimer interface [polypeptide binding]; other site 43989004761 phosphorylation site [posttranslational modification] 43989004762 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989004763 ATP binding site [chemical binding]; other site 43989004764 Mg2+ binding site [ion binding]; other site 43989004765 G-X-G motif; other site 43989004766 Uncharacterized conserved protein [Function unknown]; Region: COG1543 43989004767 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 43989004768 active site 43989004769 substrate binding site [chemical binding]; other site 43989004770 catalytic site [active] 43989004771 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 43989004772 hypothetical protein; Provisional; Region: PRK02724 43989004773 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 43989004774 putative active site [active] 43989004775 catalytic residue [active] 43989004776 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 43989004777 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 43989004778 TPR repeat; Region: TPR_11; pfam13414 43989004779 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989004780 binding surface 43989004781 TPR motif; other site 43989004782 TPR repeat; Region: TPR_11; pfam13414 43989004783 TPR repeat; Region: TPR_11; pfam13414 43989004784 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989004785 binding surface 43989004786 TPR motif; other site 43989004787 TPR repeat; Region: TPR_11; pfam13414 43989004788 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 43989004789 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 43989004790 HIGH motif; other site 43989004791 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 43989004792 active site 43989004793 KMSKS motif; other site 43989004794 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 43989004795 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 43989004796 calcium/proton exchanger (cax); Region: cax; TIGR00378 43989004797 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 43989004798 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 43989004799 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 43989004800 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 43989004801 active site 43989004802 motif I; other site 43989004803 motif II; other site 43989004804 NADH dehydrogenase subunit J; Provisional; Region: PRK12494 43989004805 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 43989004806 NADH dehydrogenase subunit K; Region: ndhK; CHL00023 43989004807 NADH dehydrogenase subunit 3; Region: ndhC; CHL00022 43989004808 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 43989004809 DNA methylase; Region: N6_N4_Mtase; pfam01555 43989004810 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 43989004811 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 43989004812 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 43989004813 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 43989004814 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 43989004815 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 43989004816 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 43989004817 NADH(P)-binding; Region: NAD_binding_10; pfam13460 43989004818 NAD binding site [chemical binding]; other site 43989004819 substrate binding site [chemical binding]; other site 43989004820 putative active site [active] 43989004821 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 43989004822 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 43989004823 Peptidase M14 Aspartoacylase (ASPA) subfamily; Region: M14_ASPA; cd06909 43989004824 active site 43989004825 Zn binding site [ion binding]; other site 43989004826 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 43989004827 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 43989004828 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 43989004829 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 43989004830 Nitrogen regulatory protein P-II; Region: P-II; smart00938 43989004831 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 43989004832 active site 43989004833 dimerization interface [polypeptide binding]; other site 43989004834 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 43989004835 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989004836 dimer interface [polypeptide binding]; other site 43989004837 phosphorylation site [posttranslational modification] 43989004838 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989004839 ATP binding site [chemical binding]; other site 43989004840 Mg2+ binding site [ion binding]; other site 43989004841 G-X-G motif; other site 43989004842 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 43989004843 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 43989004844 active site 43989004845 phosphorylation site [posttranslational modification] 43989004846 intermolecular recognition site; other site 43989004847 dimerization interface [polypeptide binding]; other site 43989004848 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 43989004849 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 43989004850 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 43989004851 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 43989004852 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 43989004853 hinge; other site 43989004854 active site 43989004855 Probable transposase; Region: OrfB_IS605; pfam01385 43989004856 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 43989004857 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 43989004858 Transposase IS200 like; Region: Y1_Tnp; pfam01797 43989004859 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 43989004860 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 43989004861 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 43989004862 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 43989004863 ATP binding site [chemical binding]; other site 43989004864 putative Mg++ binding site [ion binding]; other site 43989004865 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 43989004866 nucleotide binding region [chemical binding]; other site 43989004867 ATP-binding site [chemical binding]; other site 43989004868 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 43989004869 HRDC domain; Region: HRDC; pfam00570 43989004870 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 43989004871 DNA binding residues [nucleotide binding] 43989004872 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 43989004873 phosphoglyceromutase; Provisional; Region: PRK05434 43989004874 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 43989004875 TM2 domain; Region: TM2; cl00984 43989004876 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 43989004877 active site 43989004878 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 43989004879 Rubredoxin; Region: Rubredoxin; pfam00301 43989004880 iron binding site [ion binding]; other site 43989004881 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 43989004882 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 43989004883 Hemerythrin-like domain; Region: Hr-like; cd12108 43989004884 putative lipid kinase; Reviewed; Region: PRK00861 43989004885 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 43989004886 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 43989004887 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 43989004888 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 43989004889 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 43989004890 active site 43989004891 metal binding site [ion binding]; metal-binding site 43989004892 dimerization interface [polypeptide binding]; other site 43989004893 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 43989004894 anti sigma factor interaction site; other site 43989004895 regulatory phosphorylation site [posttranslational modification]; other site 43989004896 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 43989004897 RimM N-terminal domain; Region: RimM; pfam01782 43989004898 PRC-barrel domain; Region: PRC; pfam05239 43989004899 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 43989004900 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 43989004901 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 43989004902 SLBB domain; Region: SLBB; pfam10531 43989004903 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 43989004904 NADPH bind site [chemical binding]; other site 43989004905 putative FMN binding site [chemical binding]; other site 43989004906 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 43989004907 putative FMN binding site [chemical binding]; other site 43989004908 NADPH bind site [chemical binding]; other site 43989004909 hypothetical protein; Provisional; Region: PRK13686 43989004910 glycogen branching enzyme; Provisional; Region: PRK12313 43989004911 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 43989004912 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 43989004913 active site 43989004914 catalytic site [active] 43989004915 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 43989004916 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 43989004917 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 43989004918 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989004919 active site 43989004920 phosphorylation site [posttranslational modification] 43989004921 intermolecular recognition site; other site 43989004922 dimerization interface [polypeptide binding]; other site 43989004923 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 43989004924 DNA binding site [nucleotide binding] 43989004925 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 43989004926 putative GSH binding site [chemical binding]; other site 43989004927 catalytic residues [active] 43989004928 BolA-like protein; Region: BolA; pfam01722 43989004929 Predicted transcriptional regulator [Transcription]; Region: COG3682 43989004930 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 43989004931 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 43989004932 Peptidase family M23; Region: Peptidase_M23; pfam01551 43989004933 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 43989004934 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 43989004935 non-specific DNA interactions [nucleotide binding]; other site 43989004936 DNA binding site [nucleotide binding] 43989004937 sequence specific DNA binding site [nucleotide binding]; other site 43989004938 putative cAMP binding site [chemical binding]; other site 43989004939 Catalytic domain of Protein Kinases; Region: PKc; cd00180 43989004940 active site 43989004941 ATP binding site [chemical binding]; other site 43989004942 substrate binding site [chemical binding]; other site 43989004943 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 43989004944 activation loop (A-loop); other site 43989004945 AAA ATPase domain; Region: AAA_16; pfam13191 43989004946 Predicted ATPase [General function prediction only]; Region: COG3899 43989004947 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 43989004948 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 43989004949 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989004950 dimer interface [polypeptide binding]; other site 43989004951 phosphorylation site [posttranslational modification] 43989004952 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989004953 ATP binding site [chemical binding]; other site 43989004954 Mg2+ binding site [ion binding]; other site 43989004955 G-X-G motif; other site 43989004956 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 43989004957 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 43989004958 nucleotide binding pocket [chemical binding]; other site 43989004959 K-X-D-G motif; other site 43989004960 catalytic site [active] 43989004961 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 43989004962 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 43989004963 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 43989004964 Dimer interface [polypeptide binding]; other site 43989004965 BRCT sequence motif; other site 43989004966 Mechanosensitive ion channel; Region: MS_channel; pfam00924 43989004967 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 43989004968 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 43989004969 Mechanosensitive ion channel; Region: MS_channel; pfam00924 43989004970 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 43989004971 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 43989004972 motif II; other site 43989004973 S-adenosylmethionine synthetase; Validated; Region: PRK05250 43989004974 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 43989004975 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 43989004976 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 43989004977 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 43989004978 putative bicarbonate transporter, IctB family; Region: 2A73; TIGR00947 43989004979 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 43989004980 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 43989004981 active site 43989004982 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 43989004983 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 43989004984 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 43989004985 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 43989004986 Uncharacterized conserved protein [Function unknown]; Region: COG5464 43989004987 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 43989004988 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 43989004989 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 43989004990 active site 43989004991 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 43989004992 putative methyltransferase; Provisional; Region: PRK11524 43989004993 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 43989004994 Predicted RNA binding protein (dsRBD-like fold), HicA family [General function prediction only]; Region: COG1724 43989004995 photosystem II 47 kDa protein; Region: psbB; CHL00062 43989004996 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 43989004997 translation initiation factor IF-2; Region: IF-2; TIGR00487 43989004998 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 43989004999 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 43989005000 G1 box; other site 43989005001 putative GEF interaction site [polypeptide binding]; other site 43989005002 GTP/Mg2+ binding site [chemical binding]; other site 43989005003 Switch I region; other site 43989005004 G2 box; other site 43989005005 G3 box; other site 43989005006 Switch II region; other site 43989005007 G4 box; other site 43989005008 G5 box; other site 43989005009 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 43989005010 Translation-initiation factor 2; Region: IF-2; pfam11987 43989005011 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 43989005012 Protein of unknown function (DUF448); Region: DUF448; pfam04296 43989005013 putative RNA binding cleft [nucleotide binding]; other site 43989005014 NusA N-terminal domain; Region: NusA_N; pfam08529 43989005015 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 43989005016 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 43989005017 RNA binding site [nucleotide binding]; other site 43989005018 homodimer interface [polypeptide binding]; other site 43989005019 NusA-like KH domain; Region: KH_5; pfam13184 43989005020 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 43989005021 G-X-X-G motif; other site 43989005022 ribosome maturation protein RimP; Reviewed; Region: PRK00092 43989005023 Sm and related proteins; Region: Sm_like; cl00259 43989005024 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 43989005025 putative oligomer interface [polypeptide binding]; other site 43989005026 putative RNA binding site [nucleotide binding]; other site 43989005027 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 43989005028 substrate binding pocket [chemical binding]; other site 43989005029 substrate-Mg2+ binding site; other site 43989005030 aspartate-rich region 1; other site 43989005031 aspartate-rich region 2; other site 43989005032 calmodulin; Provisional; Region: PTZ00184 43989005033 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 43989005034 Ca2+ binding site [ion binding]; other site 43989005035 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 43989005036 Ca2+ binding site [ion binding]; other site 43989005037 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 43989005038 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 43989005039 Competence protein; Region: Competence; pfam03772 43989005040 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 43989005041 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069 43989005042 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 43989005043 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989005044 dimer interface [polypeptide binding]; other site 43989005045 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989005046 ATP binding site [chemical binding]; other site 43989005047 Mg2+ binding site [ion binding]; other site 43989005048 G-X-G motif; other site 43989005049 Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910 43989005050 malate dehydrogenase; Reviewed; Region: PRK06223 43989005051 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 43989005052 NAD(P) binding site [chemical binding]; other site 43989005053 dimer interface [polypeptide binding]; other site 43989005054 tetramer (dimer of dimers) interface [polypeptide binding]; other site 43989005055 substrate binding site [chemical binding]; other site 43989005056 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 43989005057 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 43989005058 NodB motif; other site 43989005059 active site 43989005060 catalytic site [active] 43989005061 metal binding site [ion binding]; metal-binding site 43989005062 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 43989005063 Catalytic domain of Protein Kinases; Region: PKc; cd00180 43989005064 active site 43989005065 ATP binding site [chemical binding]; other site 43989005066 substrate binding site [chemical binding]; other site 43989005067 activation loop (A-loop); other site 43989005068 TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329 43989005069 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 43989005070 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 43989005071 iron-sulfur cluster [ion binding]; other site 43989005072 [2Fe-2S] cluster binding site [ion binding]; other site 43989005073 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 43989005074 PBP superfamily domain; Region: PBP_like_2; cl17296 43989005075 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 43989005076 active site 43989005077 catalytic residues [active] 43989005078 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 43989005079 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 43989005080 substrate binding site [chemical binding]; other site 43989005081 dimer interface [polypeptide binding]; other site 43989005082 ATP binding site [chemical binding]; other site 43989005083 DDE superfamily endonuclease; Region: DDE_5; cl17874 43989005084 DNA polymerase III subunit beta; Validated; Region: PRK05643 43989005085 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 43989005086 putative DNA binding surface [nucleotide binding]; other site 43989005087 dimer interface [polypeptide binding]; other site 43989005088 beta-clamp/clamp loader binding surface; other site 43989005089 beta-clamp/translesion DNA polymerase binding surface; other site 43989005090 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 43989005091 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 43989005092 dimer interface [polypeptide binding]; other site 43989005093 tetramer interface [polypeptide binding]; other site 43989005094 PYR/PP interface [polypeptide binding]; other site 43989005095 TPP binding site [chemical binding]; other site 43989005096 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 43989005097 TPP-binding site; other site 43989005098 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 43989005099 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 43989005100 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 43989005101 putative acyl-acceptor binding pocket; other site 43989005102 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 43989005103 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 43989005104 cyanosortase-associated protein; Region: cyanosort_assoc; TIGR04153 43989005105 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 43989005106 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 43989005107 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 43989005108 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 43989005109 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 43989005110 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 43989005111 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 43989005112 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 43989005113 DNA binding residues [nucleotide binding] 43989005114 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 43989005115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 43989005116 putative substrate translocation pore; other site 43989005117 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 43989005118 MPN+ (JAMM) motif; other site 43989005119 Zinc-binding site [ion binding]; other site 43989005120 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 43989005121 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 43989005122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989005123 active site 43989005124 phosphorylation site [posttranslational modification] 43989005125 intermolecular recognition site; other site 43989005126 dimerization interface [polypeptide binding]; other site 43989005127 PAS fold; Region: PAS; pfam00989 43989005128 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989005129 putative active site [active] 43989005130 heme pocket [chemical binding]; other site 43989005131 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 43989005132 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 43989005133 metal binding site [ion binding]; metal-binding site 43989005134 active site 43989005135 I-site; other site 43989005136 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 43989005137 PAS domain S-box; Region: sensory_box; TIGR00229 43989005138 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989005139 putative active site [active] 43989005140 heme pocket [chemical binding]; other site 43989005141 PAS domain S-box; Region: sensory_box; TIGR00229 43989005142 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989005143 putative active site [active] 43989005144 heme pocket [chemical binding]; other site 43989005145 PAS domain S-box; Region: sensory_box; TIGR00229 43989005146 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989005147 PAS fold; Region: PAS_3; pfam08447 43989005148 putative active site [active] 43989005149 heme pocket [chemical binding]; other site 43989005150 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989005151 PAS domain; Region: PAS_9; pfam13426 43989005152 putative active site [active] 43989005153 heme pocket [chemical binding]; other site 43989005154 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989005155 PAS fold; Region: PAS_3; pfam08447 43989005156 putative active site [active] 43989005157 heme pocket [chemical binding]; other site 43989005158 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 43989005159 Histidine kinase; Region: HisKA_2; pfam07568 43989005160 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989005161 ATP binding site [chemical binding]; other site 43989005162 Mg2+ binding site [ion binding]; other site 43989005163 G-X-G motif; other site 43989005164 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 43989005165 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 43989005166 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 43989005167 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 43989005168 N-acetyl-D-glucosamine binding site [chemical binding]; other site 43989005169 catalytic residue [active] 43989005170 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 43989005171 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 43989005172 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 43989005173 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 43989005174 active site 43989005175 Int/Topo IB signature motif; other site 43989005176 DNA binding site [nucleotide binding] 43989005177 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 43989005178 MutS domain III; Region: MutS_III; pfam05192 43989005179 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 43989005180 Walker A/P-loop; other site 43989005181 ATP binding site [chemical binding]; other site 43989005182 Q-loop/lid; other site 43989005183 ABC transporter signature motif; other site 43989005184 Walker B; other site 43989005185 D-loop; other site 43989005186 H-loop/switch region; other site 43989005187 Smr domain; Region: Smr; pfam01713 43989005188 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 43989005189 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 43989005190 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 43989005191 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 43989005192 Phytochelatin synthase; Region: Phytochelatin; pfam05023 43989005193 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 43989005194 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 43989005195 metal binding site [ion binding]; metal-binding site 43989005196 dimer interface [polypeptide binding]; other site 43989005197 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 43989005198 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 43989005199 non-specific DNA binding site [nucleotide binding]; other site 43989005200 salt bridge; other site 43989005201 sequence-specific DNA binding site [nucleotide binding]; other site 43989005202 SOS regulatory protein LexA; Region: lexA; TIGR00498 43989005203 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 43989005204 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 43989005205 Catalytic site [active] 43989005206 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 43989005207 Citrate synthase; Region: Citrate_synt; pfam00285 43989005208 dimer interface [polypeptide binding]; other site 43989005209 active site 43989005210 oxalacetate/citrate binding site [chemical binding]; other site 43989005211 citrylCoA binding site [chemical binding]; other site 43989005212 coenzyme A binding site [chemical binding]; other site 43989005213 catalytic triad [active] 43989005214 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 43989005215 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 43989005216 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 43989005217 FeS/SAM binding site; other site 43989005218 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 43989005219 Bacterial SH3 domain; Region: SH3_3; pfam08239 43989005220 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 43989005221 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 43989005222 active site 43989005223 metal binding site [ion binding]; metal-binding site 43989005224 Protein of unknown function (DUF98); Region: DUF98; pfam01947 43989005225 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 43989005226 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 43989005227 RNA binding site [nucleotide binding]; other site 43989005228 active site 43989005229 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 43989005230 Protein of unknown function DUF86; Region: DUF86; cl01031 43989005231 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 43989005232 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 43989005233 oligomer interface [polypeptide binding]; other site 43989005234 active site residues [active] 43989005235 Clp protease; Region: CLP_protease; pfam00574 43989005236 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 43989005237 oligomer interface [polypeptide binding]; other site 43989005238 active site residues [active] 43989005239 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 43989005240 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 43989005241 metal-binding site [ion binding] 43989005242 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 43989005243 Soluble P-type ATPase [General function prediction only]; Region: COG4087 43989005244 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 43989005245 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 43989005246 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 43989005247 DXD motif; other site 43989005248 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 43989005249 putative ADP-binding pocket [chemical binding]; other site 43989005250 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 43989005251 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 43989005252 G1 box; other site 43989005253 GTP/Mg2+ binding site [chemical binding]; other site 43989005254 G2 box; other site 43989005255 Switch I region; other site 43989005256 G3 box; other site 43989005257 Switch II region; other site 43989005258 G4 box; other site 43989005259 G5 box; other site 43989005260 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 43989005261 G1 box; other site 43989005262 GTP/Mg2+ binding site [chemical binding]; other site 43989005263 G2 box; other site 43989005264 Switch I region; other site 43989005265 G3 box; other site 43989005266 Switch II region; other site 43989005267 G4 box; other site 43989005268 G5 box; other site 43989005269 Protein of unknown function (DUF3493); Region: DUF3493; pfam11998 43989005270 Phosphagen (guanidino) kinases; Region: phosphagen_kinases; cl02823 43989005271 PEP-CTERM motif; Region: VPEP; pfam07589 43989005272 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 43989005273 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 43989005274 phosphopeptide binding site; other site 43989005275 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 43989005276 cyclase homology domain; Region: CHD; cd07302 43989005277 nucleotidyl binding site; other site 43989005278 metal binding site [ion binding]; metal-binding site 43989005279 dimer interface [polypeptide binding]; other site 43989005280 Protein of unknown function (DUF3120); Region: DUF3120; pfam11318 43989005281 Uncharacterized conserved protein [Function unknown]; Region: COG5464 43989005282 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 43989005283 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 43989005284 Clp amino terminal domain; Region: Clp_N; pfam02861 43989005285 Clp amino terminal domain; Region: Clp_N; pfam02861 43989005286 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 43989005287 Walker A motif; other site 43989005288 ATP binding site [chemical binding]; other site 43989005289 Walker B motif; other site 43989005290 arginine finger; other site 43989005291 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 43989005292 Walker A motif; other site 43989005293 ATP binding site [chemical binding]; other site 43989005294 Walker B motif; other site 43989005295 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 43989005296 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 43989005297 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 43989005298 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 43989005299 allophycocyanin, beta subunit; Region: apcB; TIGR01337 43989005300 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 43989005301 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 43989005302 ATP binding site [chemical binding]; other site 43989005303 putative Mg++ binding site [ion binding]; other site 43989005304 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 43989005305 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 43989005306 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 43989005307 active site 43989005308 HIGH motif; other site 43989005309 KMSKS motif; other site 43989005310 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 43989005311 anticodon binding site; other site 43989005312 tRNA binding surface [nucleotide binding]; other site 43989005313 Uncharacterized conserved protein [Function unknown]; Region: COG1432 43989005314 LabA_like proteins; Region: LabA; cd10911 43989005315 putative metal binding site [ion binding]; other site 43989005316 putative carbohydrate kinase; Provisional; Region: PRK10565 43989005317 Uncharacterized conserved protein [Function unknown]; Region: COG0062 43989005318 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 43989005319 putative substrate binding site [chemical binding]; other site 43989005320 putative ATP binding site [chemical binding]; other site 43989005321 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 43989005322 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 43989005323 Probable transposase; Region: OrfB_IS605; pfam01385 43989005324 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 43989005325 metal binding site 2 [ion binding]; metal-binding site 43989005326 putative DNA binding helix; other site 43989005327 metal binding site 1 [ion binding]; metal-binding site 43989005328 dimer interface [polypeptide binding]; other site 43989005329 structural Zn2+ binding site [ion binding]; other site 43989005330 Response regulator receiver domain; Region: Response_reg; pfam00072 43989005331 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989005332 active site 43989005333 phosphorylation site [posttranslational modification] 43989005334 intermolecular recognition site; other site 43989005335 dimerization interface [polypeptide binding]; other site 43989005336 Protein of unknown function (DUF3685); Region: DUF3685; pfam12452 43989005337 cell division protein; Validated; Region: ftsH; CHL00176 43989005338 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 43989005339 Walker A motif; other site 43989005340 ATP binding site [chemical binding]; other site 43989005341 Walker B motif; other site 43989005342 arginine finger; other site 43989005343 Peptidase family M41; Region: Peptidase_M41; pfam01434 43989005344 photochlorophyllide reductase subunit B; Region: chlB; CHL00076 43989005345 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 43989005346 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 43989005347 Protein of unknown function (DUF2283); Region: DUF2283; cl02251 43989005348 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 43989005349 YcfA-like protein; Region: YcfA; cl00752 43989005350 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 43989005351 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 43989005352 GTPase CgtA; Reviewed; Region: obgE; PRK12299 43989005353 GTP1/OBG; Region: GTP1_OBG; pfam01018 43989005354 Obg GTPase; Region: Obg; cd01898 43989005355 G1 box; other site 43989005356 GTP/Mg2+ binding site [chemical binding]; other site 43989005357 Switch I region; other site 43989005358 G2 box; other site 43989005359 G3 box; other site 43989005360 Switch II region; other site 43989005361 G4 box; other site 43989005362 G5 box; other site 43989005363 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 43989005364 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 43989005365 Catalytic site [active] 43989005366 Rieske non-heme iron oxygenase (RO) family, Pheophorbide a oxygenase (PaO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of a small subfamily of enzymes found in plants as well as oxygenic...; Region: Rieske_RO_Alpha_PaO; cd03480 43989005367 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 43989005368 hydrophobic ligand binding site; other site 43989005369 Pheophorbide a oxygenase; Region: PaO; pfam08417 43989005370 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 43989005371 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 43989005372 Repair protein; Region: Repair_PSII; pfam04536 43989005373 precorrin-8X methylmutase; Validated; Region: PRK05953 43989005374 Precorrin-8X methylmutase; Region: CbiC; pfam02570 43989005375 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 43989005376 putative active site [active] 43989005377 substrate binding site [chemical binding]; other site 43989005378 redox center [active] 43989005379 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cd04722 43989005380 phosphate binding site [ion binding]; other site 43989005381 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 43989005382 Subunit I/III interface [polypeptide binding]; other site 43989005383 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 43989005384 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 43989005385 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 43989005386 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 43989005387 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 43989005388 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 43989005389 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989005390 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 43989005391 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989005392 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989005393 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 43989005394 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 43989005395 active site residue [active] 43989005396 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 43989005397 Response regulator receiver domain; Region: Response_reg; pfam00072 43989005398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989005399 active site 43989005400 phosphorylation site [posttranslational modification] 43989005401 intermolecular recognition site; other site 43989005402 dimerization interface [polypeptide binding]; other site 43989005403 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 43989005404 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 43989005405 Phytochrome region; Region: PHY; pfam00360 43989005406 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989005407 dimer interface [polypeptide binding]; other site 43989005408 phosphorylation site [posttranslational modification] 43989005409 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989005410 ATP binding site [chemical binding]; other site 43989005411 Mg2+ binding site [ion binding]; other site 43989005412 G-X-G motif; other site 43989005413 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989005414 putative active site [active] 43989005415 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 43989005416 ATP-binding site [chemical binding]; other site 43989005417 Gluconate-6-phosphate binding site [chemical binding]; other site 43989005418 Shikimate kinase; Region: SKI; pfam01202 43989005419 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 43989005420 Zn2+ binding site [ion binding]; other site 43989005421 Mg2+ binding site [ion binding]; other site 43989005422 topology modulation protein; Reviewed; Region: PRK08118 43989005423 AAA domain; Region: AAA_17; pfam13207 43989005424 bifunctional sterol desaturase/short chain dehydrogenase; Validated; Region: PRK07424 43989005425 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 43989005426 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 43989005427 NAD(P) binding site [chemical binding]; other site 43989005428 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 43989005429 Cation transport protein; Region: TrkH; cl17365 43989005430 TrkA-C domain; Region: TrkA_C; pfam02080 43989005431 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 43989005432 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 43989005433 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 43989005434 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 43989005435 Nucleotide binding site [chemical binding]; other site 43989005436 integral membrane protein MviN; Region: mviN; TIGR01695 43989005437 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 43989005438 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 43989005439 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 43989005440 RNA polymerase Rpc34 subunit; Region: RNA_pol_Rpc34; cl02127 43989005441 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 43989005442 rod shape-determining protein MreC; Provisional; Region: PRK13922 43989005443 rod shape-determining protein MreC; Region: MreC; pfam04085 43989005444 rod shape-determining protein MreB; Provisional; Region: PRK13927 43989005445 MreB and similar proteins; Region: MreB_like; cd10225 43989005446 nucleotide binding site [chemical binding]; other site 43989005447 Mg binding site [ion binding]; other site 43989005448 putative protofilament interaction site [polypeptide binding]; other site 43989005449 RodZ interaction site [polypeptide binding]; other site 43989005450 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 43989005451 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 43989005452 dimer interface [polypeptide binding]; other site 43989005453 ssDNA binding site [nucleotide binding]; other site 43989005454 tetramer (dimer of dimers) interface [polypeptide binding]; other site 43989005455 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 43989005456 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 43989005457 nucleotide binding site [chemical binding]; other site 43989005458 NEF interaction site [polypeptide binding]; other site 43989005459 SBD interface [polypeptide binding]; other site 43989005460 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 43989005461 Predicted membrane protein [Function unknown]; Region: COG2259 43989005462 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 43989005463 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 43989005464 E3 interaction surface; other site 43989005465 lipoyl attachment site [posttranslational modification]; other site 43989005466 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 43989005467 HlyD family secretion protein; Region: HlyD_3; pfam13437 43989005468 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 43989005469 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 43989005470 MgtE intracellular N domain; Region: MgtE_N; smart00924 43989005471 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 43989005472 Divalent cation transporter; Region: MgtE; pfam01769 43989005473 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 43989005474 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 43989005475 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 43989005476 Walker A/P-loop; other site 43989005477 ATP binding site [chemical binding]; other site 43989005478 AAA domain; Region: AAA_21; pfam13304 43989005479 acetyl-CoA synthetase; Provisional; Region: PRK00174 43989005480 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 43989005481 active site 43989005482 CoA binding site [chemical binding]; other site 43989005483 acyl-activating enzyme (AAE) consensus motif; other site 43989005484 AMP binding site [chemical binding]; other site 43989005485 acetate binding site [chemical binding]; other site 43989005486 AAA domain; Region: AAA_21; pfam13304 43989005487 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 43989005488 ABC transporter signature motif; other site 43989005489 Walker B; other site 43989005490 D-loop; other site 43989005491 H-loop/switch region; other site 43989005492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402 43989005493 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989005494 putative active site [active] 43989005495 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 43989005496 catalytic triad [active] 43989005497 Predicted permeases [General function prediction only]; Region: COG0795 43989005498 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 43989005499 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 43989005500 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 43989005501 Walker A/P-loop; other site 43989005502 ATP binding site [chemical binding]; other site 43989005503 Q-loop/lid; other site 43989005504 ABC transporter signature motif; other site 43989005505 Walker B; other site 43989005506 D-loop; other site 43989005507 H-loop/switch region; other site 43989005508 OstA-like protein; Region: OstA; pfam03968 43989005509 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 43989005510 putative active site [active] 43989005511 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 43989005512 GAF domain; Region: GAF; pfam01590 43989005513 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 43989005514 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989005515 putative active site [active] 43989005516 heme pocket [chemical binding]; other site 43989005517 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989005518 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 43989005519 putative active site [active] 43989005520 heme pocket [chemical binding]; other site 43989005521 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989005522 putative active site [active] 43989005523 PAS domain S-box; Region: sensory_box; TIGR00229 43989005524 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989005525 putative active site [active] 43989005526 heme pocket [chemical binding]; other site 43989005527 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989005528 PAS fold; Region: PAS_3; pfam08447 43989005529 putative active site [active] 43989005530 heme pocket [chemical binding]; other site 43989005531 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 43989005532 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 43989005533 metal binding site [ion binding]; metal-binding site 43989005534 active site 43989005535 I-site; other site 43989005536 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 43989005537 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 43989005538 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 43989005539 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 43989005540 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 43989005541 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 43989005542 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 43989005543 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 43989005544 ATP-grasp domain; Region: ATP-grasp_4; cl17255 43989005545 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 43989005546 IMP binding site; other site 43989005547 dimer interface [polypeptide binding]; other site 43989005548 interdomain contacts; other site 43989005549 partial ornithine binding site; other site 43989005550 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 43989005551 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 43989005552 catalytic residues [active] 43989005553 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 43989005554 Repair protein; Region: Repair_PSII; pfam04536 43989005555 FtsH Extracellular; Region: FtsH_ext; pfam06480 43989005556 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 43989005557 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 43989005558 Walker A motif; other site 43989005559 ATP binding site [chemical binding]; other site 43989005560 Walker B motif; other site 43989005561 arginine finger; other site 43989005562 Peptidase family M41; Region: Peptidase_M41; pfam01434 43989005563 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 43989005564 active site 43989005565 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 43989005566 binding surface 43989005567 TPR motif; other site 43989005568 Tetratricopeptide repeat; Region: TPR_12; pfam13424 43989005569 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 43989005570 Tetratricopeptide repeat; Region: TPR_12; pfam13424 43989005571 TPR motif; other site 43989005572 binding surface 43989005573 excinuclease ABC subunit B; Provisional; Region: PRK05298 43989005574 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 43989005575 ATP binding site [chemical binding]; other site 43989005576 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 43989005577 nucleotide binding region [chemical binding]; other site 43989005578 ATP-binding site [chemical binding]; other site 43989005579 Ultra-violet resistance protein B; Region: UvrB; pfam12344 43989005580 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 43989005581 MltA specific insert domain; Region: MltA; pfam03562 43989005582 3D domain; Region: 3D; pfam06725 43989005583 Response regulator receiver domain; Region: Response_reg; pfam00072 43989005584 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989005585 active site 43989005586 phosphorylation site [posttranslational modification] 43989005587 intermolecular recognition site; other site 43989005588 dimerization interface [polypeptide binding]; other site 43989005589 elongation factor G; Reviewed; Region: PRK00007 43989005590 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 43989005591 G1 box; other site 43989005592 putative GEF interaction site [polypeptide binding]; other site 43989005593 GTP/Mg2+ binding site [chemical binding]; other site 43989005594 Switch I region; other site 43989005595 G2 box; other site 43989005596 G3 box; other site 43989005597 Switch II region; other site 43989005598 G4 box; other site 43989005599 G5 box; other site 43989005600 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 43989005601 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 43989005602 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 43989005603 Protein of unknown function (DUF1517); Region: DUF1517; pfam07466 43989005604 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 43989005605 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 43989005606 substrate binding pocket [chemical binding]; other site 43989005607 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 43989005608 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 43989005609 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 43989005610 ABC-ATPase subunit interface; other site 43989005611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 43989005612 dimer interface [polypeptide binding]; other site 43989005613 conserved gate region; other site 43989005614 putative PBP binding loops; other site 43989005615 ABC-ATPase subunit interface; other site 43989005616 Domain of unknown function (DUF1823); Region: DUF1823; pfam08853 43989005617 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 43989005618 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 43989005619 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 43989005620 DNA binding residues [nucleotide binding] 43989005621 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 43989005622 CHAT domain; Region: CHAT; cl17868 43989005623 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 43989005624 CHASE2 domain; Region: CHASE2; pfam05226 43989005625 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 43989005626 Flavoprotein; Region: Flavoprotein; pfam02441 43989005627 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 43989005628 Protein of unknown function (DUF2555); Region: DUF2555; pfam10742 43989005629 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 43989005630 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 43989005631 active site 43989005632 Substrate binding site; other site 43989005633 Mg++ binding site; other site 43989005634 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 43989005635 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 43989005636 putative trimer interface [polypeptide binding]; other site 43989005637 putative CoA binding site [chemical binding]; other site 43989005638 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 43989005639 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 43989005640 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 43989005641 active site 43989005642 catalytic residues [active] 43989005643 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 43989005644 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 43989005645 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989005646 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989005647 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989005648 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989005649 ATP-grasp domain; Region: ATP-grasp_4; cl17255 43989005650 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 43989005651 nudix motif; other site 43989005652 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 43989005653 D-xylulose kinase; Region: XylB; TIGR01312 43989005654 nucleotide binding site [chemical binding]; other site 43989005655 Integral membrane protein DUF92; Region: DUF92; pfam01940 43989005656 Predicted membrane protein [Function unknown]; Region: COG3174 43989005657 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 43989005658 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 43989005659 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 43989005660 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 43989005661 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 43989005662 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 43989005663 Substrate binding site; other site 43989005664 Mg++ binding site; other site 43989005665 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 43989005666 active site 43989005667 substrate binding site [chemical binding]; other site 43989005668 CoA binding site [chemical binding]; other site 43989005669 Cupin domain; Region: Cupin_2; pfam07883 43989005670 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 43989005671 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 43989005672 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 43989005673 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 43989005674 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 43989005675 Probable transposase; Region: OrfB_IS605; pfam01385 43989005676 macrophage migration inhibition factor-like protein; Provisional; Region: PTZ00397 43989005677 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 43989005678 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 43989005679 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 43989005680 FeS/SAM binding site; other site 43989005681 HemN C-terminal domain; Region: HemN_C; pfam06969 43989005682 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 43989005683 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 43989005684 putative active site [active] 43989005685 G8 domain; Region: G8; pfam10162 43989005686 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 43989005687 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 43989005688 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 43989005689 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 43989005690 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 43989005691 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 43989005692 Walker A/P-loop; other site 43989005693 ATP binding site [chemical binding]; other site 43989005694 Q-loop/lid; other site 43989005695 ABC transporter signature motif; other site 43989005696 Walker B; other site 43989005697 D-loop; other site 43989005698 H-loop/switch region; other site 43989005699 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 43989005700 putative carbohydrate binding site [chemical binding]; other site 43989005701 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 43989005702 DDE superfamily endonuclease; Region: DDE_4; pfam13359 43989005703 Methyltransferase domain; Region: Methyltransf_23; pfam13489 43989005704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989005705 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 43989005706 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 43989005707 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 43989005708 active site 43989005709 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 43989005710 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 43989005711 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 43989005712 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 43989005713 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 43989005714 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 43989005715 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 43989005716 putative NAD(P) binding site [chemical binding]; other site 43989005717 active site 43989005718 putative substrate binding site [chemical binding]; other site 43989005719 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 43989005720 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989005721 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 43989005722 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989005723 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989005724 hypothetical protein; Reviewed; Region: PRK12497 43989005725 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989005726 TPR motif; other site 43989005727 TPR repeat; Region: TPR_11; pfam13414 43989005728 binding surface 43989005729 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 43989005730 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 43989005731 catalytic loop [active] 43989005732 iron binding site [ion binding]; other site 43989005733 Phycobilisome protein; Region: Phycobilisome; cl08227 43989005734 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 43989005735 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 43989005736 catalytic loop [active] 43989005737 iron binding site [ion binding]; other site 43989005738 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 43989005739 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 43989005740 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 43989005741 V4R domain; Region: V4R; pfam02830 43989005742 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 43989005743 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 43989005744 active site 43989005745 Catalytic domain of Protein Kinases; Region: PKc; cd00180 43989005746 Protein kinase domain; Region: Pkinase; pfam00069 43989005747 active site 43989005748 ATP binding site [chemical binding]; other site 43989005749 substrate binding site [chemical binding]; other site 43989005750 activation loop (A-loop); other site 43989005751 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 43989005752 active site 43989005753 SAM binding site [chemical binding]; other site 43989005754 homodimer interface [polypeptide binding]; other site 43989005755 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 43989005756 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 43989005757 active site 43989005758 ketol-acid reductoisomerase; Provisional; Region: PRK05479 43989005759 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 43989005760 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 43989005761 acetyl-CoA carboxylase, biotin carboxyl carrier protein; Region: BCCP; TIGR00531 43989005762 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 43989005763 carboxyltransferase (CT) interaction site; other site 43989005764 biotinylation site [posttranslational modification]; other site 43989005765 elongation factor P; Validated; Region: PRK00529 43989005766 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 43989005767 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 43989005768 RNA binding site [nucleotide binding]; other site 43989005769 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 43989005770 RNA binding site [nucleotide binding]; other site 43989005771 Methyltransferase domain; Region: Methyltransf_31; pfam13847 43989005772 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989005773 S-adenosylmethionine binding site [chemical binding]; other site 43989005774 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 43989005775 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 43989005776 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 43989005777 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 43989005778 YacP-like NYN domain; Region: NYN_YacP; pfam05991 43989005779 NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716 43989005780 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 43989005781 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 43989005782 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 43989005783 substrate binding site [chemical binding]; other site 43989005784 active site 43989005785 catalytic residues [active] 43989005786 heterodimer interface [polypeptide binding]; other site 43989005787 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl17742 43989005788 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 43989005789 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 43989005790 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989005791 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 43989005792 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 43989005793 ligand binding site [chemical binding]; other site 43989005794 NAD binding site [chemical binding]; other site 43989005795 dimerization interface [polypeptide binding]; other site 43989005796 catalytic site [active] 43989005797 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 43989005798 putative L-serine binding site [chemical binding]; other site 43989005799 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 43989005800 Domain of unknown function (DUF955); Region: DUF955; cl01076 43989005801 DEAD-like helicases superfamily; Region: DEXDc; smart00487 43989005802 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 43989005803 ATP binding site [chemical binding]; other site 43989005804 putative Mg++ binding site [ion binding]; other site 43989005805 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 43989005806 nucleotide binding region [chemical binding]; other site 43989005807 ATP-binding site [chemical binding]; other site 43989005808 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 43989005809 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 43989005810 trehalose synthase; Region: treS_nterm; TIGR02456 43989005811 active site 43989005812 catalytic site [active] 43989005813 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 43989005814 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 43989005815 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 43989005816 oligomeric interface; other site 43989005817 putative active site [active] 43989005818 homodimer interface [polypeptide binding]; other site 43989005819 DNA-sulfur modification-associated; Region: DndB; pfam14072 43989005820 PemK-like protein; Region: PemK; pfam02452 43989005821 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989005822 putative active site [active] 43989005823 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 43989005824 DNA binding residues [nucleotide binding] 43989005825 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 43989005826 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 43989005827 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 43989005828 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989005829 S-adenosylmethionine binding site [chemical binding]; other site 43989005830 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 43989005831 MutS domain I; Region: MutS_I; pfam01624 43989005832 MutS domain II; Region: MutS_II; pfam05188 43989005833 MutS domain III; Region: MutS_III; pfam05192 43989005834 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 43989005835 Walker A/P-loop; other site 43989005836 ATP binding site [chemical binding]; other site 43989005837 Q-loop/lid; other site 43989005838 ABC transporter signature motif; other site 43989005839 Walker B; other site 43989005840 D-loop; other site 43989005841 H-loop/switch region; other site 43989005842 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 43989005843 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 43989005844 P-loop; other site 43989005845 Magnesium ion binding site [ion binding]; other site 43989005846 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 43989005847 Magnesium ion binding site [ion binding]; other site 43989005848 enolase; Provisional; Region: eno; PRK00077 43989005849 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 43989005850 dimer interface [polypeptide binding]; other site 43989005851 metal binding site [ion binding]; metal-binding site 43989005852 substrate binding pocket [chemical binding]; other site 43989005853 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 43989005854 CHAT domain; Region: CHAT; cl17868 43989005855 AAA ATPase domain; Region: AAA_16; pfam13191 43989005856 Peptidase family M48; Region: Peptidase_M48; cl12018 43989005857 Integral membrane protein TerC family; Region: TerC; cl10468 43989005858 polyphosphate kinase; Provisional; Region: PRK05443 43989005859 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 43989005860 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 43989005861 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 43989005862 putative domain interface [polypeptide binding]; other site 43989005863 putative active site [active] 43989005864 catalytic site [active] 43989005865 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 43989005866 putative domain interface [polypeptide binding]; other site 43989005867 putative active site [active] 43989005868 catalytic site [active] 43989005869 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 43989005870 active site 43989005871 photosystem I assembly protein Ycf4; Provisional; Region: PRK02542 43989005872 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 43989005873 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 43989005874 Catalytic domain of Protein Kinases; Region: PKc; cd00180 43989005875 active site 43989005876 ATP binding site [chemical binding]; other site 43989005877 substrate binding site [chemical binding]; other site 43989005878 activation loop (A-loop); other site 43989005879 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 43989005880 structural tetrad; other site 43989005881 PQQ-like domain; Region: PQQ_2; pfam13360 43989005882 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 43989005883 phosphopeptide binding site; other site 43989005884 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 43989005885 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 43989005886 FAD binding pocket [chemical binding]; other site 43989005887 FAD binding motif [chemical binding]; other site 43989005888 phosphate binding motif [ion binding]; other site 43989005889 beta-alpha-beta structure motif; other site 43989005890 NAD binding pocket [chemical binding]; other site 43989005891 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 43989005892 catalytic loop [active] 43989005893 iron binding site [ion binding]; other site 43989005894 YcfA-like protein; Region: YcfA; cl00752 43989005895 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 43989005896 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 43989005897 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 43989005898 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 43989005899 Caspase domain; Region: Peptidase_C14; pfam00656 43989005900 FOG: WD40 repeat [General function prediction only]; Region: COG2319 43989005901 WD40 repeats; Region: WD40; smart00320 43989005902 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 43989005903 structural tetrad; other site 43989005904 FOG: WD40 repeat [General function prediction only]; Region: COG2319 43989005905 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 43989005906 structural tetrad; other site 43989005907 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 43989005908 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 43989005909 HlyD family secretion protein; Region: HlyD_3; pfam13437 43989005910 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 43989005911 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 43989005912 ligand binding site [chemical binding]; other site 43989005913 flexible hinge region; other site 43989005914 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 43989005915 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 43989005916 putative active site [active] 43989005917 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 43989005918 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 43989005919 Walker A/P-loop; other site 43989005920 ATP binding site [chemical binding]; other site 43989005921 Q-loop/lid; other site 43989005922 ABC transporter signature motif; other site 43989005923 Walker B; other site 43989005924 D-loop; other site 43989005925 H-loop/switch region; other site 43989005926 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 43989005927 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 43989005928 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 43989005929 FOG: WD40 repeat [General function prediction only]; Region: COG2319 43989005930 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 43989005931 structural tetrad; other site 43989005932 hypothetical protein; Provisional; Region: PRK13683 43989005933 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 43989005934 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 43989005935 dimer interface [polypeptide binding]; other site 43989005936 ssDNA binding site [nucleotide binding]; other site 43989005937 tetramer (dimer of dimers) interface [polypeptide binding]; other site 43989005938 Methyltransferase domain; Region: Methyltransf_23; pfam13489 43989005939 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989005940 S-adenosylmethionine binding site [chemical binding]; other site 43989005941 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 43989005942 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989005943 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989005944 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 43989005945 Transcriptional regulator [Transcription]; Region: LytR; COG1316 43989005946 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 43989005947 Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493 43989005948 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 43989005949 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 43989005950 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 43989005951 trimer interface [polypeptide binding]; other site 43989005952 active site 43989005953 UDP-GlcNAc binding site [chemical binding]; other site 43989005954 lipid binding site [chemical binding]; lipid-binding site 43989005955 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 43989005956 hypothetical protein; Provisional; Region: PRK07338 43989005957 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 43989005958 metal binding site [ion binding]; metal-binding site 43989005959 dimer interface [polypeptide binding]; other site 43989005960 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 43989005961 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 43989005962 potential catalytic triad [active] 43989005963 conserved cys residue [active] 43989005964 light-harvesting-like protein 3; Provisional; Region: PLN00014 43989005965 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 43989005966 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 43989005967 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 43989005968 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 43989005969 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 43989005970 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 43989005971 Coenzyme A binding pocket [chemical binding]; other site 43989005972 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 43989005973 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 43989005974 NADH dehydrogenase subunit 4L; Region: ndhE; CHL00015 43989005975 NADH dehydrogenase subunit 6; Region: ndhG; CHL00016 43989005976 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 43989005977 NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403 43989005978 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 43989005979 NADH dehydrogenase; Region: NADHdh; cl00469 43989005980 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 43989005981 Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957 43989005982 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 43989005983 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 43989005984 TPP-binding site [chemical binding]; other site 43989005985 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 43989005986 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 43989005987 aromatic arch; other site 43989005988 DCoH dimer interaction site [polypeptide binding]; other site 43989005989 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 43989005990 DCoH tetramer interaction site [polypeptide binding]; other site 43989005991 substrate binding site [chemical binding]; other site 43989005992 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 43989005993 dimer interface [polypeptide binding]; other site 43989005994 catalytic triad [active] 43989005995 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 43989005996 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 43989005997 proline aminopeptidase P II; Provisional; Region: PRK10879 43989005998 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 43989005999 active site 43989006000 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 43989006001 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 43989006002 Walker A/P-loop; other site 43989006003 ATP binding site [chemical binding]; other site 43989006004 Q-loop/lid; other site 43989006005 ABC transporter signature motif; other site 43989006006 Walker B; other site 43989006007 D-loop; other site 43989006008 H-loop/switch region; other site 43989006009 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 43989006010 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 43989006011 putative NADP binding site [chemical binding]; other site 43989006012 putative substrate binding site [chemical binding]; other site 43989006013 active site 43989006014 CheB methylesterase; Region: CheB_methylest; pfam01339 43989006015 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 43989006016 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 43989006017 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 43989006018 Tropomyosin like; Region: Tropomyosin_1; pfam12718 43989006019 PAS domain; Region: PAS_10; pfam13596 43989006020 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 43989006021 putative active site [active] 43989006022 heme pocket [chemical binding]; other site 43989006023 PAS fold; Region: PAS_4; pfam08448 43989006024 PAS fold; Region: PAS_3; pfam08447 43989006025 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 43989006026 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989006027 dimer interface [polypeptide binding]; other site 43989006028 phosphorylation site [posttranslational modification] 43989006029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989006030 ATP binding site [chemical binding]; other site 43989006031 Mg2+ binding site [ion binding]; other site 43989006032 G-X-G motif; other site 43989006033 Response regulator receiver domain; Region: Response_reg; pfam00072 43989006034 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989006035 active site 43989006036 phosphorylation site [posttranslational modification] 43989006037 intermolecular recognition site; other site 43989006038 dimerization interface [polypeptide binding]; other site 43989006039 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 43989006040 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 43989006041 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 43989006042 iron-sulfur cluster [ion binding]; other site 43989006043 [2Fe-2S] cluster binding site [ion binding]; other site 43989006044 Uncharacterized conserved protein [Function unknown]; Region: COG3349 43989006045 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 43989006046 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 43989006047 proposed catalytic triad [active] 43989006048 active site nucleophile [active] 43989006049 cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068 43989006050 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 43989006051 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 43989006052 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 43989006053 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 43989006054 CAAX protease self-immunity; Region: Abi; pfam02517 43989006055 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 43989006056 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 43989006057 haemagglutination activity domain; Region: Haemagg_act; pfam05860 43989006058 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 43989006059 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 43989006060 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 43989006061 Surface antigen; Region: Bac_surface_Ag; pfam01103 43989006062 PAS fold; Region: PAS_4; pfam08448 43989006063 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989006064 PAS domain; Region: PAS_9; pfam13426 43989006065 putative active site [active] 43989006066 heme pocket [chemical binding]; other site 43989006067 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 43989006068 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 43989006069 metal binding site [ion binding]; metal-binding site 43989006070 active site 43989006071 I-site; other site 43989006072 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 43989006073 glutaminase A; Region: Gln_ase; TIGR03814 43989006074 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 43989006075 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 43989006076 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 43989006077 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 43989006078 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 43989006079 ligand binding site [chemical binding]; other site 43989006080 flexible hinge region; other site 43989006081 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 43989006082 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 43989006083 CHASE2 domain; Region: CHASE2; pfam05226 43989006084 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 43989006085 cyclase homology domain; Region: CHD; cd07302 43989006086 nucleotidyl binding site; other site 43989006087 metal binding site [ion binding]; metal-binding site 43989006088 dimer interface [polypeptide binding]; other site 43989006089 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 43989006090 glycogen branching enzyme; Provisional; Region: PRK05402 43989006091 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 43989006092 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 43989006093 active site 43989006094 catalytic site [active] 43989006095 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 43989006096 TPR repeat; Region: TPR_11; pfam13414 43989006097 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989006098 binding surface 43989006099 TPR motif; other site 43989006100 Tetratricopeptide repeat; Region: TPR_12; pfam13424 43989006101 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 43989006102 ABC1 family; Region: ABC1; pfam03109 43989006103 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 43989006104 active site 43989006105 ATP binding site [chemical binding]; other site 43989006106 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 43989006107 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 43989006108 Substrate binding site; other site 43989006109 Cupin domain; Region: Cupin_2; cl17218 43989006110 DNA polymerase I; Provisional; Region: PRK05755 43989006111 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 43989006112 active site 43989006113 metal binding site 1 [ion binding]; metal-binding site 43989006114 putative 5' ssDNA interaction site; other site 43989006115 metal binding site 3; metal-binding site 43989006116 metal binding site 2 [ion binding]; metal-binding site 43989006117 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 43989006118 putative DNA binding site [nucleotide binding]; other site 43989006119 putative metal binding site [ion binding]; other site 43989006120 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 43989006121 active site 43989006122 catalytic site [active] 43989006123 substrate binding site [chemical binding]; other site 43989006124 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 43989006125 active site 43989006126 DNA binding site [nucleotide binding] 43989006127 catalytic site [active] 43989006128 CO2 hydration protein (ChpXY); Region: ChpXY; pfam10216 43989006129 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 43989006130 active site clefts [active] 43989006131 zinc binding site [ion binding]; other site 43989006132 dimer interface [polypeptide binding]; other site 43989006133 DDE superfamily endonuclease; Region: DDE_3; pfam13358 43989006134 Homeodomain-like domain; Region: HTH_23; pfam13384 43989006135 Protein of unknown function (DUF3110); Region: DUF3110; pfam11360 43989006136 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 43989006137 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 43989006138 putative active site [active] 43989006139 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 43989006140 Peptidase family M50; Region: Peptidase_M50; pfam02163 43989006141 active site 43989006142 putative substrate binding region [chemical binding]; other site 43989006143 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 43989006144 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 43989006145 substrate binding pocket [chemical binding]; other site 43989006146 membrane-bound complex binding site; other site 43989006147 hinge residues; other site 43989006148 Protein of unknown function, DUF273; Region: DUF273; pfam03314 43989006149 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 43989006150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 43989006151 conserved gate region; other site 43989006152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 43989006153 putative PBP binding loops; other site 43989006154 dimer interface [polypeptide binding]; other site 43989006155 ABC-ATPase subunit interface; other site 43989006156 Domain of unknown function DUF20; Region: UPF0118; pfam01594 43989006157 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 43989006158 Domain of unknown function DUF39; Region: DUF39; pfam01837 43989006159 putative methanogenesis marker 16 metalloprotein; Region: methan_mark_16; TIGR03287 43989006160 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 43989006161 Part of AAA domain; Region: AAA_19; pfam13245 43989006162 Family description; Region: UvrD_C_2; pfam13538 43989006163 TPR repeat; Region: TPR_11; pfam13414 43989006164 Tetratricopeptide repeat; Region: TPR_2; pfam07719 43989006165 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 43989006166 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 43989006167 putative ligand binding site [chemical binding]; other site 43989006168 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989006169 binding surface 43989006170 TPR motif; other site 43989006171 TPR repeat; Region: TPR_11; pfam13414 43989006172 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 43989006173 active site 43989006174 catalytic triad [active] 43989006175 oxyanion hole [active] 43989006176 Methyltransferase domain; Region: Methyltransf_26; pfam13659 43989006177 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 43989006178 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 43989006179 putative dimer interface [polypeptide binding]; other site 43989006180 putative anticodon binding site; other site 43989006181 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 43989006182 homodimer interface [polypeptide binding]; other site 43989006183 motif 1; other site 43989006184 motif 2; other site 43989006185 active site 43989006186 motif 3; other site 43989006187 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 43989006188 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 43989006189 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 43989006190 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 43989006191 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 43989006192 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 43989006193 motif II; other site 43989006194 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 43989006195 S-layer homology domain; Region: SLH; pfam00395 43989006196 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 43989006197 TPR repeat; Region: TPR_11; pfam13414 43989006198 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989006199 binding surface 43989006200 TPR motif; other site 43989006201 TPR repeat; Region: TPR_11; pfam13414 43989006202 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989006203 binding surface 43989006204 Tetratricopeptide repeat; Region: TPR_16; pfam13432 43989006205 TPR motif; other site 43989006206 TPR repeat; Region: TPR_11; pfam13414 43989006207 TPR repeat; Region: TPR_11; pfam13414 43989006208 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372 43989006209 Protein of unknown function (DUF790); Region: DUF790; pfam05626 43989006210 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 43989006211 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 43989006212 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 43989006213 PAS domain S-box; Region: sensory_box; TIGR00229 43989006214 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989006215 putative active site [active] 43989006216 heme pocket [chemical binding]; other site 43989006217 PAS fold; Region: PAS_4; pfam08448 43989006218 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989006219 putative active site [active] 43989006220 heme pocket [chemical binding]; other site 43989006221 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 43989006222 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 43989006223 metal binding site [ion binding]; metal-binding site 43989006224 active site 43989006225 I-site; other site 43989006226 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 43989006227 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 43989006228 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 43989006229 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 43989006230 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 43989006231 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 43989006232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 43989006233 dimer interface [polypeptide binding]; other site 43989006234 conserved gate region; other site 43989006235 putative PBP binding loops; other site 43989006236 ABC-ATPase subunit interface; other site 43989006237 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 43989006238 active site 43989006239 C factor cell-cell signaling protein; Provisional; Region: PRK09009 43989006240 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 43989006241 NADP binding site [chemical binding]; other site 43989006242 homodimer interface [polypeptide binding]; other site 43989006243 active site 43989006244 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 43989006245 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 43989006246 active site 43989006247 motif I; other site 43989006248 motif II; other site 43989006249 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 43989006250 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 43989006251 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 43989006252 catalytic residue [active] 43989006253 putative FPP diphosphate binding site; other site 43989006254 putative FPP binding hydrophobic cleft; other site 43989006255 dimer interface [polypeptide binding]; other site 43989006256 putative IPP diphosphate binding site; other site 43989006257 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 43989006258 dinuclear metal binding motif [ion binding]; other site 43989006259 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 43989006260 Tetratricopeptide repeat; Region: TPR_12; pfam13424 43989006261 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 43989006262 active site 43989006263 ribulose/triose binding site [chemical binding]; other site 43989006264 phosphate binding site [ion binding]; other site 43989006265 substrate (anthranilate) binding pocket [chemical binding]; other site 43989006266 product (indole) binding pocket [chemical binding]; other site 43989006267 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 43989006268 HEAT repeats; Region: HEAT_2; pfam13646 43989006269 HEAT repeats; Region: HEAT_2; pfam13646 43989006270 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 43989006271 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 43989006272 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 43989006273 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 43989006274 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 43989006275 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 43989006276 NAD binding site [chemical binding]; other site 43989006277 dimerization interface [polypeptide binding]; other site 43989006278 product binding site; other site 43989006279 substrate binding site [chemical binding]; other site 43989006280 zinc binding site [ion binding]; other site 43989006281 catalytic residues [active] 43989006282 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 43989006283 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 43989006284 Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941 43989006285 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 43989006286 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 43989006287 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 43989006288 catalytic loop [active] 43989006289 iron binding site [ion binding]; other site 43989006290 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 43989006291 4Fe-4S binding domain; Region: Fer4; pfam00037 43989006292 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 43989006293 dimer interface [polypeptide binding]; other site 43989006294 [2Fe-2S] cluster binding site [ion binding]; other site 43989006295 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 43989006296 SLBB domain; Region: SLBB; pfam10531 43989006297 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 43989006298 bidirectional hydrogenase complex protein HoxE; Reviewed; Region: PRK07571 43989006299 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 43989006300 putative dimer interface [polypeptide binding]; other site 43989006301 [2Fe-2S] cluster binding site [ion binding]; other site 43989006302 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989006303 putative active site [active] 43989006304 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989006305 putative active site [active] 43989006306 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 43989006307 putative heme binding pocket [chemical binding]; other site 43989006308 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 43989006309 heme binding pocket [chemical binding]; other site 43989006310 heme ligand [chemical binding]; other site 43989006311 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 43989006312 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 43989006313 FeS/SAM binding site; other site 43989006314 HemN C-terminal domain; Region: HemN_C; pfam06969 43989006315 DpnII restriction endonuclease; Region: DpnII; pfam04556 43989006316 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 43989006317 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 43989006318 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 43989006319 metal binding site 2 [ion binding]; metal-binding site 43989006320 putative DNA binding helix; other site 43989006321 metal binding site 1 [ion binding]; metal-binding site 43989006322 dimer interface [polypeptide binding]; other site 43989006323 structural Zn2+ binding site [ion binding]; other site 43989006324 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 43989006325 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 43989006326 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 43989006327 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 43989006328 ATP binding site [chemical binding]; other site 43989006329 putative Mg++ binding site [ion binding]; other site 43989006330 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 43989006331 nucleotide binding region [chemical binding]; other site 43989006332 ATP-binding site [chemical binding]; other site 43989006333 rRNA-processing arch domain; Region: rRNA_proc-arch; pfam13234 43989006334 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 43989006335 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 43989006336 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 43989006337 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 43989006338 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 43989006339 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 43989006340 DNA binding residues [nucleotide binding] 43989006341 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 43989006342 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 43989006343 catalytic site [active] 43989006344 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 43989006345 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 43989006346 active site 43989006347 catalytic tetrad [active] 43989006348 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 43989006349 Bifunctional nuclease; Region: DNase-RNase; pfam02577 43989006350 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 43989006351 Lumazine binding domain; Region: Lum_binding; pfam00677 43989006352 Lumazine binding domain; Region: Lum_binding; pfam00677 43989006353 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 43989006354 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 43989006355 PHP domain; Region: PHP; pfam02811 43989006356 active site 43989006357 Uncharacterized conserved protein [Function unknown]; Region: COG0398 43989006358 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 43989006359 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 43989006360 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 43989006361 Walker A motif; other site 43989006362 ATP binding site [chemical binding]; other site 43989006363 Walker B motif; other site 43989006364 R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645 43989006365 RxxxH motif; other site 43989006366 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 43989006367 Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617 43989006368 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 43989006369 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 43989006370 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 43989006371 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 43989006372 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 43989006373 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 43989006374 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 43989006375 ligand binding site [chemical binding]; other site 43989006376 flexible hinge region; other site 43989006377 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 43989006378 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 43989006379 putative active site [active] 43989006380 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 43989006381 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 43989006382 Walker A/P-loop; other site 43989006383 ATP binding site [chemical binding]; other site 43989006384 Q-loop/lid; other site 43989006385 ABC transporter signature motif; other site 43989006386 Walker B; other site 43989006387 D-loop; other site 43989006388 H-loop/switch region; other site 43989006389 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 43989006390 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 43989006391 F0F1 ATP synthase subunit B; Validated; Region: PRK06568 43989006392 HlyD family secretion protein; Region: HlyD_3; pfam13437 43989006393 Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045 43989006394 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 43989006395 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 43989006396 CoA binding domain; Region: CoA_binding; pfam02629 43989006397 CoA-ligase; Region: Ligase_CoA; pfam00549 43989006398 homoserine dehydrogenase; Provisional; Region: PRK06349 43989006399 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 43989006400 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 43989006401 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 43989006402 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 43989006403 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 43989006404 Peptidase family M23; Region: Peptidase_M23; pfam01551 43989006405 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 43989006406 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 43989006407 NAD binding site [chemical binding]; other site 43989006408 homodimer interface [polypeptide binding]; other site 43989006409 active site 43989006410 substrate binding site [chemical binding]; other site 43989006411 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 43989006412 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 43989006413 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 43989006414 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 43989006415 active site 43989006416 two component system sensor kinase SsrB; Provisional; Region: PRK15369 43989006417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989006418 active site 43989006419 phosphorylation site [posttranslational modification] 43989006420 intermolecular recognition site; other site 43989006421 dimerization interface [polypeptide binding]; other site 43989006422 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 43989006423 DNA binding residues [nucleotide binding] 43989006424 MASE1; Region: MASE1; pfam05231 43989006425 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 43989006426 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 43989006427 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 43989006428 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989006429 dimer interface [polypeptide binding]; other site 43989006430 phosphorylation site [posttranslational modification] 43989006431 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989006432 ATP binding site [chemical binding]; other site 43989006433 Mg2+ binding site [ion binding]; other site 43989006434 G-X-G motif; other site 43989006435 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 43989006436 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 43989006437 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 43989006438 Probable transposase; Region: OrfB_IS605; pfam01385 43989006439 Transposase IS200 like; Region: Y1_Tnp; pfam01797 43989006440 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 43989006441 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 43989006442 FAD binding domain; Region: FAD_binding_4; pfam01565 43989006443 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 43989006444 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 43989006445 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 43989006446 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 43989006447 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 43989006448 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 43989006449 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 43989006450 ligand binding site [chemical binding]; other site 43989006451 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 43989006452 dimerization interface [polypeptide binding]; other site 43989006453 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989006454 dimer interface [polypeptide binding]; other site 43989006455 phosphorylation site [posttranslational modification] 43989006456 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989006457 ATP binding site [chemical binding]; other site 43989006458 Mg2+ binding site [ion binding]; other site 43989006459 G-X-G motif; other site 43989006460 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989006461 active site 43989006462 phosphorylation site [posttranslational modification] 43989006463 intermolecular recognition site; other site 43989006464 dimerization interface [polypeptide binding]; other site 43989006465 Response regulator receiver domain; Region: Response_reg; pfam00072 43989006466 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989006467 active site 43989006468 phosphorylation site [posttranslational modification] 43989006469 intermolecular recognition site; other site 43989006470 dimerization interface [polypeptide binding]; other site 43989006471 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 43989006472 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 43989006473 metal binding site [ion binding]; metal-binding site 43989006474 active site 43989006475 I-site; other site 43989006476 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 43989006477 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 43989006478 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 43989006479 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 43989006480 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 43989006481 Surface antigen; Region: Bac_surface_Ag; pfam01103 43989006482 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 43989006483 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 43989006484 ATP binding site [chemical binding]; other site 43989006485 active site 43989006486 substrate binding site [chemical binding]; other site 43989006487 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 43989006488 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 43989006489 putative catalytic cysteine [active] 43989006490 Tetratricopeptide repeat; Region: TPR_12; pfam13424 43989006491 Protein of unknown function, DUF481; Region: DUF481; cl01213 43989006492 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 43989006493 Mechanosensitive ion channel; Region: MS_channel; pfam00924 43989006494 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 43989006495 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 43989006496 Walker A/P-loop; other site 43989006497 ATP binding site [chemical binding]; other site 43989006498 Q-loop/lid; other site 43989006499 ABC transporter signature motif; other site 43989006500 Walker B; other site 43989006501 D-loop; other site 43989006502 H-loop/switch region; other site 43989006503 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 43989006504 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 43989006505 Walker A/P-loop; other site 43989006506 ATP binding site [chemical binding]; other site 43989006507 Q-loop/lid; other site 43989006508 ABC transporter signature motif; other site 43989006509 Walker B; other site 43989006510 D-loop; other site 43989006511 H-loop/switch region; other site 43989006512 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 43989006513 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 43989006514 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 43989006515 catalytic residues [active] 43989006516 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 43989006517 glucosylglycerol-phosphate synthase; Region: gluc_glyc_Psyn; TIGR02398 43989006518 active site 43989006519 homotetramer interface [polypeptide binding]; other site 43989006520 YcfA-like protein; Region: YcfA; pfam07927 43989006521 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 43989006522 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 43989006523 carotene isomerase; Region: carot_isom; TIGR02730 43989006524 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 43989006525 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 43989006526 Predicted membrane protein [Function unknown]; Region: COG3174 43989006527 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 43989006528 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 43989006529 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 43989006530 Moco binding site; other site 43989006531 metal coordination site [ion binding]; other site 43989006532 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 43989006533 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 43989006534 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 43989006535 Probable Catalytic site; other site 43989006536 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 43989006537 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 43989006538 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 43989006539 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 43989006540 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 43989006541 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 43989006542 dimer interface [polypeptide binding]; other site 43989006543 decamer (pentamer of dimers) interface [polypeptide binding]; other site 43989006544 catalytic triad [active] 43989006545 peroxidatic and resolving cysteines [active] 43989006546 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 43989006547 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 43989006548 substrate binding pocket [chemical binding]; other site 43989006549 Ion channel; Region: Ion_trans_2; pfam07885 43989006550 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 43989006551 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 43989006552 membrane-bound complex binding site; other site 43989006553 hinge residues; other site 43989006554 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 43989006555 Ligand Binding Site [chemical binding]; other site 43989006556 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 43989006557 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 43989006558 NAD(P) binding site [chemical binding]; other site 43989006559 homotetramer interface [polypeptide binding]; other site 43989006560 homodimer interface [polypeptide binding]; other site 43989006561 active site 43989006562 XisH protein; Region: XisH; pfam08814 43989006563 XisI protein; Region: XisI; pfam08869 43989006564 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 43989006565 Mrr N-terminal domain; Region: Mrr_N; pfam14338 43989006566 Restriction endonuclease; Region: Mrr_cat; pfam04471 43989006567 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 43989006568 active site 43989006569 NTP binding site [chemical binding]; other site 43989006570 metal binding triad [ion binding]; metal-binding site 43989006571 antibiotic binding site [chemical binding]; other site 43989006572 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 43989006573 Beta-lactamase; Region: Beta-lactamase; pfam00144 43989006574 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 43989006575 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 43989006576 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 43989006577 Walker A/P-loop; other site 43989006578 ATP binding site [chemical binding]; other site 43989006579 Q-loop/lid; other site 43989006580 ABC transporter signature motif; other site 43989006581 Walker B; other site 43989006582 D-loop; other site 43989006583 H-loop/switch region; other site 43989006584 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 43989006585 dimer interface [polypeptide binding]; other site 43989006586 RNA polymerase sigma factor; Provisional; Region: PRK12518 43989006587 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 43989006588 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 43989006589 DNA binding residues [nucleotide binding] 43989006590 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 43989006591 DHH family; Region: DHH; pfam01368 43989006592 DHHA1 domain; Region: DHHA1; pfam02272 43989006593 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 43989006594 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 43989006595 tellurium resistance terB-like protein; Region: terB_like; cd07177 43989006596 metal binding site [ion binding]; metal-binding site 43989006597 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 43989006598 deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556 43989006599 DNA photolyase; Region: DNA_photolyase; pfam00875 43989006600 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 43989006601 active site 43989006602 methionine sulfoxide reductase A; Provisional; Region: PRK14054 43989006603 Domain of unknown function (DUF389); Region: DUF389; pfam04087 43989006604 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 43989006605 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 43989006606 Hexamer interface [polypeptide binding]; other site 43989006607 Hexagonal pore residue; other site 43989006608 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 43989006609 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 43989006610 Hexamer interface [polypeptide binding]; other site 43989006611 Hexagonal pore residue; other site 43989006612 Uncharacterized conserved protein [Function unknown]; Region: COG1262 43989006613 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 43989006614 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 43989006615 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 43989006616 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 43989006617 Walker A/P-loop; other site 43989006618 ATP binding site [chemical binding]; other site 43989006619 Q-loop/lid; other site 43989006620 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 43989006621 ABC transporter signature motif; other site 43989006622 Walker B; other site 43989006623 D-loop; other site 43989006624 H-loop/switch region; other site 43989006625 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 43989006626 TrkA-N domain; Region: TrkA_N; pfam02254 43989006627 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 43989006628 TrkA-N domain; Region: TrkA_N; pfam02254 43989006629 TrkA-C domain; Region: TrkA_C; pfam02080 43989006630 Mechanosensitive ion channel; Region: MS_channel; pfam00924 43989006631 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 43989006632 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 43989006633 ligand binding site [chemical binding]; other site 43989006634 flexible hinge region; other site 43989006635 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 43989006636 MoaE interaction surface [polypeptide binding]; other site 43989006637 MoeB interaction surface [polypeptide binding]; other site 43989006638 thiocarboxylated glycine; other site 43989006639 threonine synthase; Validated; Region: PRK07591 43989006640 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 43989006641 homodimer interface [polypeptide binding]; other site 43989006642 pyridoxal 5'-phosphate binding site [chemical binding]; other site 43989006643 catalytic residue [active] 43989006644 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 43989006645 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 43989006646 TM-ABC transporter signature motif; other site 43989006647 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 43989006648 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 43989006649 P-loop; other site 43989006650 Magnesium ion binding site [ion binding]; other site 43989006651 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 43989006652 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 43989006653 N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796 43989006654 putative active site [active] 43989006655 catalytic site [active] 43989006656 Domon-like ligand-binding domains; Region: DOMON_like; cd00241 43989006657 putative ligand binding site [chemical binding]; other site 43989006658 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 43989006659 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 43989006660 substrate binding pocket [chemical binding]; other site 43989006661 membrane-bound complex binding site; other site 43989006662 hinge residues; other site 43989006663 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 43989006664 Transglycosylase; Region: Transgly; pfam00912 43989006665 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 43989006666 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 43989006667 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 43989006668 catalytic core [active] 43989006669 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 43989006670 catalytic core [active] 43989006671 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 43989006672 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 43989006673 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 43989006674 DDE superfamily endonuclease; Region: DDE_4; pfam13359 43989006675 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 43989006676 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 43989006677 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 43989006678 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 43989006679 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 43989006680 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 43989006681 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 43989006682 MreB/Mbl protein; Region: MreB_Mbl; pfam06723 43989006683 nucleotide binding site [chemical binding]; other site 43989006684 putative NEF/HSP70 interaction site [polypeptide binding]; other site 43989006685 SBD interface [polypeptide binding]; other site 43989006686 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 43989006687 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 43989006688 substrate binding pocket [chemical binding]; other site 43989006689 chain length determination region; other site 43989006690 substrate-Mg2+ binding site; other site 43989006691 catalytic residues [active] 43989006692 aspartate-rich region 1; other site 43989006693 active site lid residues [active] 43989006694 aspartate-rich region 2; other site 43989006695 glutamate racemase; Provisional; Region: PRK00865 43989006696 AMIN domain; Region: AMIN; pfam11741 43989006697 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 43989006698 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 43989006699 active site 43989006700 metal binding site [ion binding]; metal-binding site 43989006701 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 43989006702 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 43989006703 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989006704 putative active site [active] 43989006705 L-aminoadipate-semialdehyde dehydrogenase; Region: alpha_am_amid; TIGR03443 43989006706 Predicted helicase [General function prediction only]; Region: COG4889 43989006707 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 43989006708 Fasciclin domain; Region: Fasciclin; pfam02469 43989006709 cell division topological specificity factor MinE; Provisional; Region: PRK13988 43989006710 septum site-determining protein MinD; Region: minD_bact; TIGR01968 43989006711 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 43989006712 P-loop; other site 43989006713 ADP binding residues [chemical binding]; other site 43989006714 Switch I; other site 43989006715 Switch II; other site 43989006716 septum formation inhibitor; Reviewed; Region: minC; PRK00513 43989006717 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 43989006718 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 43989006719 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 43989006720 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 43989006721 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 43989006722 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 43989006723 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 43989006724 Predicted flavoprotein [General function prediction only]; Region: COG0431 43989006725 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 43989006726 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 43989006727 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 43989006728 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 43989006729 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 43989006730 D2 subunit of photosystem II (PS II); Region: Photosystem-II_D2; cd09288 43989006731 D1 interface; other site 43989006732 chlorophyll binding site; other site 43989006733 pheophytin binding site; other site 43989006734 beta carotene binding site; other site 43989006735 cytochrome b559 beta interface; other site 43989006736 quinone binding site; other site 43989006737 cytochrome b559 alpha interface; other site 43989006738 protein J interface; other site 43989006739 protein H interface; other site 43989006740 protein X interface; other site 43989006741 core light harvesting protein interface; other site 43989006742 protein L interface; other site 43989006743 CP43 interface; other site 43989006744 protein T interface; other site 43989006745 Fe binding site [ion binding]; other site 43989006746 protein M interface; other site 43989006747 Mn-stabilizing polypeptide interface; other site 43989006748 bromide binding site; other site 43989006749 cytochrome c-550 interface; other site 43989006750 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 43989006751 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 43989006752 Ligand binding site; other site 43989006753 Putative Catalytic site; other site 43989006754 DXD motif; other site 43989006755 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 43989006756 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 43989006757 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 43989006758 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 43989006759 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 43989006760 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 43989006761 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 43989006762 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 43989006763 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234 43989006764 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 43989006765 hypothetical protein; Reviewed; Region: PRK00024 43989006766 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 43989006767 MPN+ (JAMM) motif; other site 43989006768 Zinc-binding site [ion binding]; other site 43989006769 Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069 43989006770 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 43989006771 DNA binding site [nucleotide binding] 43989006772 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 43989006773 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989006774 S-adenosylmethionine binding site [chemical binding]; other site 43989006775 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 43989006776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 43989006777 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 43989006778 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 43989006779 FeS/SAM binding site; other site 43989006780 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 43989006781 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 43989006782 DDE superfamily endonuclease; Region: DDE_4; pfam13359 43989006783 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 43989006784 Response regulator receiver domain; Region: Response_reg; pfam00072 43989006785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989006786 active site 43989006787 phosphorylation site [posttranslational modification] 43989006788 intermolecular recognition site; other site 43989006789 dimerization interface [polypeptide binding]; other site 43989006790 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 43989006791 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 43989006792 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989006793 active site 43989006794 phosphorylation site [posttranslational modification] 43989006795 intermolecular recognition site; other site 43989006796 dimerization interface [polypeptide binding]; other site 43989006797 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 43989006798 DNA binding residues [nucleotide binding] 43989006799 dimerization interface [polypeptide binding]; other site 43989006800 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 43989006801 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989006802 active site 43989006803 phosphorylation site [posttranslational modification] 43989006804 intermolecular recognition site; other site 43989006805 dimerization interface [polypeptide binding]; other site 43989006806 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989006807 dimer interface [polypeptide binding]; other site 43989006808 phosphorylation site [posttranslational modification] 43989006809 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989006810 ATP binding site [chemical binding]; other site 43989006811 Mg2+ binding site [ion binding]; other site 43989006812 G-X-G motif; other site 43989006813 Response regulator receiver domain; Region: Response_reg; pfam00072 43989006814 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989006815 active site 43989006816 phosphorylation site [posttranslational modification] 43989006817 intermolecular recognition site; other site 43989006818 dimerization interface [polypeptide binding]; other site 43989006819 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 43989006820 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989006821 dimer interface [polypeptide binding]; other site 43989006822 phosphorylation site [posttranslational modification] 43989006823 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989006824 ATP binding site [chemical binding]; other site 43989006825 Mg2+ binding site [ion binding]; other site 43989006826 G-X-G motif; other site 43989006827 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 43989006828 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 43989006829 active site 43989006830 catalytic tetrad [active] 43989006831 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 43989006832 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 43989006833 Uncharacterized conserved protein [Function unknown]; Region: COG1434 43989006834 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 43989006835 putative active site [active] 43989006836 ChaB; Region: ChaB; pfam06150 43989006837 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 43989006838 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 43989006839 dimerization interface [polypeptide binding]; other site 43989006840 DPS ferroxidase diiron center [ion binding]; other site 43989006841 ion pore; other site 43989006842 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 43989006843 Protein of unknown function (DUF565); Region: DUF565; pfam04483 43989006844 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 43989006845 active site 43989006846 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 43989006847 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 43989006848 nucleotide binding site [chemical binding]; other site 43989006849 Methyltransferase domain; Region: Methyltransf_31; pfam13847 43989006850 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989006851 S-adenosylmethionine binding site [chemical binding]; other site 43989006852 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 43989006853 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 43989006854 putative metal binding site [ion binding]; other site 43989006855 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 43989006856 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 43989006857 putative metal binding site [ion binding]; other site 43989006858 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 43989006859 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 43989006860 putative metal binding site [ion binding]; other site 43989006861 primosome assembly protein PriA; Validated; Region: PRK05580 43989006862 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 43989006863 ATP binding site [chemical binding]; other site 43989006864 putative Mg++ binding site [ion binding]; other site 43989006865 helicase superfamily c-terminal domain; Region: HELICc; smart00490 43989006866 ATP-binding site [chemical binding]; other site 43989006867 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 43989006868 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 43989006869 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 43989006870 Walker A motif; other site 43989006871 ATP binding site [chemical binding]; other site 43989006872 Walker B motif; other site 43989006873 arginine finger; other site 43989006874 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 43989006875 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 43989006876 catalytic core [active] 43989006877 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 43989006878 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 43989006879 Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429 43989006880 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 43989006881 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 43989006882 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 43989006883 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 43989006884 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 43989006885 Inward rectifier potassium channel; Region: IRK; pfam01007 43989006886 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 43989006887 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 43989006888 Family description; Region: VCBS; pfam13517 43989006889 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 43989006890 Protein export membrane protein; Region: SecD_SecF; cl14618 43989006891 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 43989006892 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 43989006893 dimerization interface [polypeptide binding]; other site 43989006894 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989006895 dimer interface [polypeptide binding]; other site 43989006896 phosphorylation site [posttranslational modification] 43989006897 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989006898 ATP binding site [chemical binding]; other site 43989006899 Mg2+ binding site [ion binding]; other site 43989006900 G-X-G motif; other site 43989006901 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 43989006902 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 43989006903 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 43989006904 NADP binding site [chemical binding]; other site 43989006905 active site 43989006906 putative substrate binding site [chemical binding]; other site 43989006907 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 43989006908 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 43989006909 substrate binding site; other site 43989006910 metal-binding site 43989006911 Oligomer interface; other site 43989006912 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 43989006913 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 43989006914 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 43989006915 cofactor binding site; other site 43989006916 DNA binding site [nucleotide binding] 43989006917 substrate interaction site [chemical binding]; other site 43989006918 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 43989006919 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 43989006920 Amidinotransferase; Region: Amidinotransf; cl12043 43989006921 Uncharacterized conserved protein [Function unknown]; Region: COG1915 43989006922 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144 43989006923 homodimer interface [polypeptide binding]; other site 43989006924 Domain of unknown function DUF29; Region: DUF29; pfam01724 43989006925 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 43989006926 short chain dehydrogenase; Validated; Region: PRK08324 43989006927 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 43989006928 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 43989006929 NAD(P) binding site [chemical binding]; other site 43989006930 active site 43989006931 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 43989006932 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 43989006933 Walker A/P-loop; other site 43989006934 ATP binding site [chemical binding]; other site 43989006935 Q-loop/lid; other site 43989006936 ABC transporter signature motif; other site 43989006937 Walker B; other site 43989006938 D-loop; other site 43989006939 H-loop/switch region; other site 43989006940 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 43989006941 PBP superfamily domain; Region: PBP_like; cl17867 43989006942 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 43989006943 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 43989006944 dimer interface [polypeptide binding]; other site 43989006945 conserved gate region; other site 43989006946 ABC-ATPase subunit interface; other site 43989006947 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 43989006948 Thermostable Phosphite Dehydrogenase; Region: PTDH; cd12157 43989006949 homodimer interface [polypeptide binding]; other site 43989006950 ligand binding site [chemical binding]; other site 43989006951 NAD binding site [chemical binding]; other site 43989006952 catalytic site [active] 43989006953 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12870 43989006954 UbiA prenyltransferase family; Region: UbiA; pfam01040 43989006955 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 43989006956 Domain of unknown function (DUF364); Region: DUF364; pfam04016 43989006957 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 43989006958 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 43989006959 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 43989006960 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 43989006961 DNA binding residues [nucleotide binding] 43989006962 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 43989006963 HEAT repeats; Region: HEAT_2; pfam13646 43989006964 HEAT repeats; Region: HEAT_2; pfam13646 43989006965 HEAT repeats; Region: HEAT_2; pfam13646 43989006966 HEAT repeats; Region: HEAT_2; pfam13646 43989006967 ferrochelatase; Reviewed; Region: hemH; PRK00035 43989006968 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 43989006969 C-terminal domain interface [polypeptide binding]; other site 43989006970 active site 43989006971 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 43989006972 active site 43989006973 N-terminal domain interface [polypeptide binding]; other site 43989006974 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; pfam00504 43989006975 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 43989006976 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 43989006977 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989006978 S-adenosylmethionine binding site [chemical binding]; other site 43989006979 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; pfam01716 43989006980 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 43989006981 heme binding pocket [chemical binding]; other site 43989006982 heme ligand [chemical binding]; other site 43989006983 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989006984 putative active site [active] 43989006985 hydrolase, alpha/beta fold family protein; Region: PLN02824 43989006986 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 43989006987 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 43989006988 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 43989006989 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 43989006990 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 43989006991 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 43989006992 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 43989006993 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 43989006994 bifunctional 3-hydroxyacyl-CoA dehydrogenase/thioesterase; Validated; Region: PRK07531 43989006995 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 43989006996 Domain of unknown function DUF29; Region: DUF29; pfam01724 43989006997 Restriction endonuclease; Region: Mrr_cat; pfam04471 43989006998 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 43989006999 DNA methylase; Region: N6_N4_Mtase; pfam01555 43989007000 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 43989007001 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 43989007002 Tetratricopeptide repeat; Region: TPR_12; pfam13424 43989007003 Tetratricopeptide repeat; Region: TPR_12; pfam13424 43989007004 Protein of unknown function, DUF481; Region: DUF481; pfam04338 43989007005 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 43989007006 catalytic center binding site [active] 43989007007 ATP binding site [chemical binding]; other site 43989007008 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 43989007009 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 43989007010 dimer interface [polypeptide binding]; other site 43989007011 ADP-ribose binding site [chemical binding]; other site 43989007012 active site 43989007013 nudix motif; other site 43989007014 metal binding site [ion binding]; metal-binding site 43989007015 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 43989007016 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 43989007017 NAD(P) binding site [chemical binding]; other site 43989007018 active site 43989007019 Domain of unknown function (DUF1817); Region: DUF1817; pfam08847 43989007020 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 43989007021 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 43989007022 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 43989007023 catalytic triad [active] 43989007024 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 43989007025 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 43989007026 Predicted membrane protein [Function unknown]; Region: COG3463 43989007027 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 43989007028 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428 43989007029 dimerization interface [polypeptide binding]; other site 43989007030 active site 43989007031 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 43989007032 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 43989007033 Ligand Binding Site [chemical binding]; other site 43989007034 TilS substrate binding domain; Region: TilS; pfam09179 43989007035 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 43989007036 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 43989007037 pyridoxal 5'-phosphate binding site [chemical binding]; other site 43989007038 homodimer interface [polypeptide binding]; other site 43989007039 catalytic residue [active] 43989007040 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 43989007041 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 43989007042 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 43989007043 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 43989007044 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 43989007045 motif II; other site 43989007046 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 43989007047 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 43989007048 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 43989007049 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 43989007050 catalytic residue [active] 43989007051 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 43989007052 glycine dehydrogenase; Provisional; Region: PRK05367 43989007053 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 43989007054 tetramer interface [polypeptide binding]; other site 43989007055 pyridoxal 5'-phosphate binding site [chemical binding]; other site 43989007056 catalytic residue [active] 43989007057 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 43989007058 tetramer interface [polypeptide binding]; other site 43989007059 pyridoxal 5'-phosphate binding site [chemical binding]; other site 43989007060 catalytic residue [active] 43989007061 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 43989007062 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 43989007063 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 43989007064 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 43989007065 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 43989007066 metal binding site [ion binding]; metal-binding site 43989007067 active site 43989007068 I-site; other site 43989007069 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 43989007070 active site 43989007071 phosphorylation site [posttranslational modification] 43989007072 dimerization interface [polypeptide binding]; other site 43989007073 signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705 43989007074 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 43989007075 tandem repeat interface [polypeptide binding]; other site 43989007076 oligomer interface [polypeptide binding]; other site 43989007077 active site residues [active] 43989007078 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 43989007079 tandem repeat interface [polypeptide binding]; other site 43989007080 oligomer interface [polypeptide binding]; other site 43989007081 active site residues [active] 43989007082 recombination protein F; Reviewed; Region: recF; PRK00064 43989007083 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 43989007084 Walker A/P-loop; other site 43989007085 ATP binding site [chemical binding]; other site 43989007086 Q-loop/lid; other site 43989007087 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 43989007088 ABC transporter signature motif; other site 43989007089 Walker B; other site 43989007090 D-loop; other site 43989007091 H-loop/switch region; other site 43989007092 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 43989007093 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 43989007094 pyrroline-5-carboxylate reductase; Region: PLN02688 43989007095 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 43989007096 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 43989007097 Fatty acid desaturase; Region: FA_desaturase; pfam00487 43989007098 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 43989007099 putative di-iron ligands [ion binding]; other site 43989007100 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 43989007101 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 43989007102 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989007103 TPR motif; other site 43989007104 binding surface 43989007105 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989007106 binding surface 43989007107 TPR repeat; Region: TPR_11; pfam13414 43989007108 TPR motif; other site 43989007109 GTPase Era; Reviewed; Region: era; PRK00089 43989007110 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 43989007111 G1 box; other site 43989007112 GTP/Mg2+ binding site [chemical binding]; other site 43989007113 Switch I region; other site 43989007114 G2 box; other site 43989007115 Switch II region; other site 43989007116 G3 box; other site 43989007117 G4 box; other site 43989007118 G5 box; other site 43989007119 KH domain; Region: KH_2; pfam07650 43989007120 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 43989007121 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 43989007122 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989007123 ATP binding site [chemical binding]; other site 43989007124 Mg2+ binding site [ion binding]; other site 43989007125 G-X-G motif; other site 43989007126 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 43989007127 Response regulator receiver domain; Region: Response_reg; pfam00072 43989007128 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989007129 active site 43989007130 phosphorylation site [posttranslational modification] 43989007131 intermolecular recognition site; other site 43989007132 dimerization interface [polypeptide binding]; other site 43989007133 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 43989007134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989007135 active site 43989007136 phosphorylation site [posttranslational modification] 43989007137 intermolecular recognition site; other site 43989007138 dimerization interface [polypeptide binding]; other site 43989007139 photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515 43989007140 dihydroorotase; Provisional; Region: PRK07369 43989007141 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 43989007142 active site 43989007143 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989007144 putative active site [active] 43989007145 TPR repeat; Region: TPR_11; pfam13414 43989007146 Tetratricopeptide repeat; Region: TPR_1; pfam00515 43989007147 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989007148 binding surface 43989007149 TPR motif; other site 43989007150 TPR repeat; Region: TPR_11; pfam13414 43989007151 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 43989007152 active site 43989007153 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 43989007154 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 43989007155 S-layer homology domain; Region: SLH; pfam00395 43989007156 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 43989007157 FeoA domain; Region: FeoA; pfam04023 43989007158 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 43989007159 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 43989007160 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 43989007161 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 43989007162 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 43989007163 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 43989007164 active site residue [active] 43989007165 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl17861 43989007166 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 43989007167 AIR carboxylase; Region: AIRC; smart01001 43989007168 glycine cleavage system protein H; Provisional; Region: PRK13380 43989007169 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 43989007170 lipoyl attachment site [posttranslational modification]; other site 43989007171 uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792 43989007172 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 43989007173 ATP-grasp domain; Region: ATP-grasp_4; cl17255 43989007174 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 43989007175 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 43989007176 putative active site [active] 43989007177 Zn binding site [ion binding]; other site 43989007178 Lipoxygenase; Region: Lipoxygenase; pfam00305 43989007179 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 43989007180 Phycobilisome protein; Region: Phycobilisome; cl08227 43989007181 phycocyanin, alpha subunit; Region: phycocy_alpha; TIGR01338 43989007182 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 43989007183 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 43989007184 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 43989007185 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 43989007186 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 43989007187 HEAT repeats; Region: HEAT_2; pfam13646 43989007188 PBS lyase HEAT-like repeat; Region: HEAT_PBS; pfam03130 43989007189 HEAT repeats; Region: HEAT_2; pfam13646 43989007190 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 43989007191 TPP-binding site [chemical binding]; other site 43989007192 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 43989007193 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 43989007194 PYR/PP interface [polypeptide binding]; other site 43989007195 dimer interface [polypeptide binding]; other site 43989007196 TPP binding site [chemical binding]; other site 43989007197 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 43989007198 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 43989007199 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 43989007200 ligand binding site; other site 43989007201 oligomer interface; other site 43989007202 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 43989007203 dimer interface [polypeptide binding]; other site 43989007204 N-terminal domain interface [polypeptide binding]; other site 43989007205 sulfate 1 binding site; other site 43989007206 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 43989007207 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 43989007208 NAD(P) binding site [chemical binding]; other site 43989007209 active site 43989007210 methionine sulfoxide reductase A; Provisional; Region: PRK13014 43989007211 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 43989007212 Peptidase family M23; Region: Peptidase_M23; pfam01551 43989007213 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 43989007214 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 43989007215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 43989007216 BT1 family; Region: BT1; pfam03092 43989007217 putative substrate translocation pore; other site 43989007218 hypothetical protein; Validated; Region: PRK07411 43989007219 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 43989007220 ATP binding site [chemical binding]; other site 43989007221 substrate interface [chemical binding]; other site 43989007222 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 43989007223 active site residue [active] 43989007224 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 43989007225 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 43989007226 Walker A/P-loop; other site 43989007227 ATP binding site [chemical binding]; other site 43989007228 Q-loop/lid; other site 43989007229 ABC transporter signature motif; other site 43989007230 Walker B; other site 43989007231 D-loop; other site 43989007232 H-loop/switch region; other site 43989007233 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 43989007234 mce related protein; Region: MCE; pfam02470 43989007235 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 43989007236 dimer interface [polypeptide binding]; other site 43989007237 putative CheW interface [polypeptide binding]; other site 43989007238 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 43989007239 ligand binding site [chemical binding]; other site 43989007240 flexible hinge region; other site 43989007241 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 43989007242 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 43989007243 putative active site [active] 43989007244 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 43989007245 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 43989007246 Walker A/P-loop; other site 43989007247 ATP binding site [chemical binding]; other site 43989007248 Q-loop/lid; other site 43989007249 ABC transporter signature motif; other site 43989007250 Walker B; other site 43989007251 D-loop; other site 43989007252 H-loop/switch region; other site 43989007253 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 43989007254 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 43989007255 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 43989007256 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 43989007257 HlyD family secretion protein; Region: HlyD_3; pfam13437 43989007258 Protein of unknown function (DUF3102); Region: DUF3102; pfam11300 43989007259 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 43989007260 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 43989007261 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 43989007262 NAD(P) binding site [chemical binding]; other site 43989007263 catalytic residues [active] 43989007264 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 43989007265 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 43989007266 FMN binding site [chemical binding]; other site 43989007267 active site 43989007268 catalytic residues [active] 43989007269 substrate binding site [chemical binding]; other site 43989007270 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 43989007271 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 43989007272 substrate binding pocket [chemical binding]; other site 43989007273 membrane-bound complex binding site; other site 43989007274 Predicted methyltransferases [General function prediction only]; Region: COG0313 43989007275 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 43989007276 putative SAM binding site [chemical binding]; other site 43989007277 putative homodimer interface [polypeptide binding]; other site 43989007278 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 43989007279 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 43989007280 substrate binding site [chemical binding]; other site 43989007281 ATP binding site [chemical binding]; other site 43989007282 Cation efflux family; Region: Cation_efflux; cl00316 43989007283 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 43989007284 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 43989007285 PIN domain; Region: PIN_3; pfam13470 43989007286 DNA binding domain, excisionase family; Region: excise; TIGR01764 43989007287 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 43989007288 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 43989007289 inhibitor-cofactor binding pocket; inhibition site 43989007290 pyridoxal 5'-phosphate binding site [chemical binding]; other site 43989007291 catalytic residue [active] 43989007292 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 43989007293 Ligand Binding Site [chemical binding]; other site 43989007294 aspartate aminotransferase; Provisional; Region: PRK05764 43989007295 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 43989007296 pyridoxal 5'-phosphate binding site [chemical binding]; other site 43989007297 homodimer interface [polypeptide binding]; other site 43989007298 catalytic residue [active] 43989007299 Protein of unknown function (DUF3181); Region: DUF3181; pfam11378 43989007300 2TM domain; Region: 2TM; pfam13239 43989007301 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 43989007302 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 43989007303 MgtE intracellular N domain; Region: MgtE_N; smart00924 43989007304 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 43989007305 Divalent cation transporter; Region: MgtE; pfam01769 43989007306 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 43989007307 Cytochrome P450; Region: p450; cl12078 43989007308 Uncharacterized conserved protein [Function unknown]; Region: COG4095 43989007309 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 43989007310 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 43989007311 dimerization interface [polypeptide binding]; other site 43989007312 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 43989007313 ATP binding site [chemical binding]; other site 43989007314 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989007315 putative active site [active] 43989007316 XisH protein; Region: XisH; pfam08814 43989007317 XisI protein; Region: XisI; pfam08869 43989007318 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 43989007319 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 43989007320 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989007321 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989007322 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 43989007323 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989007324 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989007325 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 43989007326 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 43989007327 Fatty acid desaturase; Region: FA_desaturase; pfam00487 43989007328 Di-iron ligands [ion binding]; other site 43989007329 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 43989007330 FAD binding domain; Region: FAD_binding_4; pfam01565 43989007331 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 43989007332 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 43989007333 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 43989007334 catalytic residue [active] 43989007335 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 43989007336 FO synthase subunit 1; Reviewed; Region: cofG; PRK06245 43989007337 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 43989007338 FeS/SAM binding site; other site 43989007339 Predicted membrane protein [Function unknown]; Region: COG2259 43989007340 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 43989007341 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 43989007342 FMN binding site [chemical binding]; other site 43989007343 active site 43989007344 substrate binding site [chemical binding]; other site 43989007345 catalytic residue [active] 43989007346 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 43989007347 Double-stranded DNA-binding domain; Region: dsDNA_bind; cl00928 43989007348 GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins; Region: GIY-YIG_AtGrxS16_like; cd10450 43989007349 GIY-YIG motif/motif A; other site 43989007350 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 43989007351 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 43989007352 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 43989007353 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 43989007354 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457 43989007355 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 43989007356 FeS/SAM binding site; other site 43989007357 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 43989007358 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 43989007359 tocopherol O-methyltransferase; Region: PLN02244 43989007360 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989007361 S-adenosylmethionine binding site [chemical binding]; other site 43989007362 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 43989007363 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 43989007364 MoxR-like ATPases [General function prediction only]; Region: COG0714 43989007365 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 43989007366 Walker A motif; other site 43989007367 ATP binding site [chemical binding]; other site 43989007368 Walker B motif; other site 43989007369 arginine finger; other site 43989007370 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 43989007371 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 43989007372 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 43989007373 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 43989007374 TrkA-N domain; Region: TrkA_N; pfam02254 43989007375 Domain of unknown function (DUF427); Region: DUF427; pfam04248 43989007376 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989007377 TPR repeat; Region: TPR_11; pfam13414 43989007378 binding surface 43989007379 TPR motif; other site 43989007380 TPR repeat; Region: TPR_11; pfam13414 43989007381 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989007382 binding surface 43989007383 TPR motif; other site 43989007384 Tetratricopeptide repeat; Region: TPR_16; pfam13432 43989007385 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989007386 binding surface 43989007387 TPR motif; other site 43989007388 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 43989007389 GIY-YIG motif/motif A; other site 43989007390 active site 43989007391 catalytic site [active] 43989007392 Predicted membrane protein [Function unknown]; Region: COG2259 43989007393 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 43989007394 classical (c) SDRs; Region: SDR_c; cd05233 43989007395 NAD(P) binding site [chemical binding]; other site 43989007396 active site 43989007397 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 43989007398 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 43989007399 E3 interaction surface; other site 43989007400 lipoyl attachment site [posttranslational modification]; other site 43989007401 e3 binding domain; Region: E3_binding; pfam02817 43989007402 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 43989007403 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 43989007404 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 43989007405 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989007406 TrkA-N domain; Region: TrkA_N; pfam02254 43989007407 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 43989007408 TrkA-N domain; Region: TrkA_N; pfam02254 43989007409 NAD synthetase; Provisional; Region: PRK13981 43989007410 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 43989007411 multimer interface [polypeptide binding]; other site 43989007412 active site 43989007413 catalytic triad [active] 43989007414 protein interface 1 [polypeptide binding]; other site 43989007415 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 43989007416 homodimer interface [polypeptide binding]; other site 43989007417 NAD binding pocket [chemical binding]; other site 43989007418 ATP binding pocket [chemical binding]; other site 43989007419 Mg binding site [ion binding]; other site 43989007420 active-site loop [active] 43989007421 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 43989007422 nudix motif; other site 43989007423 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 43989007424 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 43989007425 active site 43989007426 (T/H)XGH motif; other site 43989007427 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 43989007428 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 43989007429 active site 43989007430 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 43989007431 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 43989007432 metal ion-dependent adhesion site (MIDAS); other site 43989007433 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 43989007434 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442 43989007435 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 43989007436 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 43989007437 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 43989007438 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 43989007439 active site flap/lid [active] 43989007440 nucleophilic elbow; other site 43989007441 catalytic triad [active] 43989007442 M28 Zn-Peptidases; Region: M28_like_1; cd05640 43989007443 Peptidase family M28; Region: Peptidase_M28; pfam04389 43989007444 metal binding site [ion binding]; metal-binding site 43989007445 glutaminase; Provisional; Region: PRK00971 43989007446 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 43989007447 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 43989007448 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 43989007449 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 43989007450 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 43989007451 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 43989007452 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 43989007453 dimer interface [polypeptide binding]; other site 43989007454 FMN binding site [chemical binding]; other site 43989007455 Pirin-related protein [General function prediction only]; Region: COG1741 43989007456 Pirin; Region: Pirin; pfam02678 43989007457 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 43989007458 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 43989007459 Cupin domain; Region: Cupin_2; cl17218 43989007460 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 43989007461 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 43989007462 Nucleoside recognition; Region: Gate; pfam07670 43989007463 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 43989007464 Protein of unknown function (DUF952); Region: DUF952; pfam06108 43989007465 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 43989007466 Mechanosensitive ion channel; Region: MS_channel; pfam00924 43989007467 phosphoenolpyruvate synthase; Region: PEP_synth; TIGR01418 43989007468 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 43989007469 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 43989007470 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 43989007471 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989007472 S-adenosylmethionine binding site [chemical binding]; other site 43989007473 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 43989007474 putative hydrophobic ligand binding site [chemical binding]; other site 43989007475 9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732 43989007476 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 43989007477 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 43989007478 Predicted membrane protein [Function unknown]; Region: COG4094 43989007479 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 43989007480 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 43989007481 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 43989007482 putative dimerization interface [polypeptide binding]; other site 43989007483 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 43989007484 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 43989007485 dimer interface [polypeptide binding]; other site 43989007486 motif 1; other site 43989007487 active site 43989007488 motif 2; other site 43989007489 motif 3; other site 43989007490 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 43989007491 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 43989007492 HSP70 interaction site [polypeptide binding]; other site 43989007493 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989007494 binding surface 43989007495 TPR motif; other site 43989007496 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 43989007497 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 43989007498 active site 43989007499 dimerization interface [polypeptide binding]; other site 43989007500 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 43989007501 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 43989007502 phosphopeptide binding site; other site 43989007503 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 43989007504 metal binding site [ion binding]; metal-binding site 43989007505 active site 43989007506 I-site; other site 43989007507 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 43989007508 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 43989007509 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 43989007510 phosphopeptide binding site; other site 43989007511 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 43989007512 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 43989007513 metal binding site [ion binding]; metal-binding site 43989007514 active site 43989007515 I-site; other site 43989007516 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 43989007517 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746 43989007518 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 43989007519 PetM family of cytochrome b6f complex subunit 7; Region: PetM; pfam08041 43989007520 photosystem II reaction center protein Psb28; Region: PS_II_psb28; TIGR03047 43989007521 Predicted membrane protein [Function unknown]; Region: COG2119 43989007522 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 43989007523 Predicted membrane protein [Function unknown]; Region: COG2119 43989007524 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 43989007525 Protein of unknown function (DUF3146); Region: DUF3146; pfam11344 43989007526 extracellular substrate-binding orphan protein, GRRM family; Region: orph_peri_GRRM; TIGR04262 43989007527 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 43989007528 substrate binding pocket [chemical binding]; other site 43989007529 membrane-bound complex binding site; other site 43989007530 hinge residues; other site 43989007531 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 43989007532 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 43989007533 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 43989007534 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 43989007535 putative ADP-binding pocket [chemical binding]; other site 43989007536 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 43989007537 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 43989007538 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 43989007539 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 43989007540 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 43989007541 Walker A/P-loop; other site 43989007542 ATP binding site [chemical binding]; other site 43989007543 Q-loop/lid; other site 43989007544 ABC transporter signature motif; other site 43989007545 Walker B; other site 43989007546 D-loop; other site 43989007547 H-loop/switch region; other site 43989007548 Phosphotransferase enzyme family; Region: APH; pfam01636 43989007549 Predicted kinase [General function prediction only]; Region: COG4857; cl17281 43989007550 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 43989007551 Stage II sporulation protein; Region: SpoIID; pfam08486 43989007552 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 43989007553 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 43989007554 ligand binding site [chemical binding]; other site 43989007555 flexible hinge region; other site 43989007556 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 43989007557 putative switch regulator; other site 43989007558 non-specific DNA interactions [nucleotide binding]; other site 43989007559 DNA binding site [nucleotide binding] 43989007560 sequence specific DNA binding site [nucleotide binding]; other site 43989007561 putative cAMP binding site [chemical binding]; other site 43989007562 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 43989007563 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 43989007564 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 43989007565 ligand binding site [chemical binding]; other site 43989007566 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 43989007567 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333 43989007568 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 43989007569 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 43989007570 FeS/SAM binding site; other site 43989007571 TRAM domain; Region: TRAM; pfam01938 43989007572 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 43989007573 gamma subunit interface [polypeptide binding]; other site 43989007574 epsilon subunit interface [polypeptide binding]; other site 43989007575 LBP interface [polypeptide binding]; other site 43989007576 ATP synthase CF1 beta subunit; Region: atpB; CHL00060 43989007577 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 43989007578 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 43989007579 alpha subunit interaction interface [polypeptide binding]; other site 43989007580 Walker A motif; other site 43989007581 ATP binding site [chemical binding]; other site 43989007582 Walker B motif; other site 43989007583 inhibitor binding site; inhibition site 43989007584 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 43989007585 hydrolase, alpha/beta fold family protein; Region: PLN02824 43989007586 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 43989007587 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 43989007588 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 43989007589 metal-binding site 43989007590 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 43989007591 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 43989007592 putative active site [active] 43989007593 putative metal binding site [ion binding]; other site 43989007594 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 43989007595 Ligand Binding Site [chemical binding]; other site 43989007596 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 43989007597 Ligand Binding Site [chemical binding]; other site 43989007598 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 43989007599 Catalytic domain of Protein Kinases; Region: PKc; cd00180 43989007600 active site 43989007601 ATP binding site [chemical binding]; other site 43989007602 substrate binding site [chemical binding]; other site 43989007603 activation loop (A-loop); other site 43989007604 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 43989007605 recombination protein RecR; Reviewed; Region: recR; PRK00076 43989007606 Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278 43989007607 RecR protein; Region: RecR; pfam02132 43989007608 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 43989007609 putative active site [active] 43989007610 putative metal-binding site [ion binding]; other site 43989007611 tetramer interface [polypeptide binding]; other site 43989007612 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 43989007613 non-specific DNA binding site [nucleotide binding]; other site 43989007614 salt bridge; other site 43989007615 sequence-specific DNA binding site [nucleotide binding]; other site 43989007616 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 43989007617 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 43989007618 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 43989007619 putative active site [active] 43989007620 putative NTP binding site [chemical binding]; other site 43989007621 putative nucleic acid binding site [nucleotide binding]; other site 43989007622 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 43989007623 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 43989007624 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 43989007625 active site 43989007626 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929 43989007627 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 43989007628 putative active site [active] 43989007629 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 43989007630 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 43989007631 non-specific DNA binding site [nucleotide binding]; other site 43989007632 salt bridge; other site 43989007633 sequence-specific DNA binding site [nucleotide binding]; other site 43989007634 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 43989007635 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 43989007636 four helix bundle protein; Region: TIGR02436 43989007637 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 43989007638 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 43989007639 metal binding triad [ion binding]; metal-binding site 43989007640 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 43989007641 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 43989007642 YcfA-like protein; Region: YcfA; pfam07927 43989007643 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 43989007644 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 43989007645 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989007646 binding surface 43989007647 TPR motif; other site 43989007648 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989007649 binding surface 43989007650 TPR motif; other site 43989007651 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 43989007652 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 43989007653 Methyltransferase domain; Region: Methyltransf_24; pfam13578 43989007654 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 43989007655 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 43989007656 active site 43989007657 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 43989007658 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 43989007659 PemK-like protein; Region: PemK; pfam02452 43989007660 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 43989007661 Protein of unknown function (DUF497); Region: DUF497; cl01108 43989007662 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 43989007663 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 43989007664 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 43989007665 putative active site [active] 43989007666 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 43989007667 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 43989007668 homodimer interface [polypeptide binding]; other site 43989007669 pyridoxal 5'-phosphate binding site [chemical binding]; other site 43989007670 catalytic residue [active] 43989007671 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 43989007672 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 43989007673 Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085 43989007674 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 43989007675 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 43989007676 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 43989007677 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 43989007678 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 43989007679 active site 43989007680 catalytic site [active] 43989007681 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 43989007682 Glutaminase; Region: Glutaminase; cl00907 43989007683 glutaminase A; Region: Gln_ase; TIGR03814 43989007684 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 43989007685 Methyltransferase domain; Region: Methyltransf_25; pfam13649 43989007686 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 43989007687 homodimer interface [polypeptide binding]; other site 43989007688 pyridoxal 5'-phosphate binding site [chemical binding]; other site 43989007689 catalytic residue [active] 43989007690 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 43989007691 metal binding site 2 [ion binding]; metal-binding site 43989007692 putative DNA binding helix; other site 43989007693 metal binding site 1 [ion binding]; metal-binding site 43989007694 dimer interface [polypeptide binding]; other site 43989007695 structural Zn2+ binding site [ion binding]; other site 43989007696 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 43989007697 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 43989007698 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 43989007699 putative active site [active] 43989007700 catalytic triad [active] 43989007701 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 43989007702 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 43989007703 dimer interface [polypeptide binding]; other site 43989007704 active site 43989007705 metal binding site [ion binding]; metal-binding site 43989007706 glutathione binding site [chemical binding]; other site 43989007707 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 43989007708 Mechanosensitive ion channel; Region: MS_channel; pfam00924 43989007709 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 43989007710 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 43989007711 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 43989007712 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 43989007713 glutamine binding [chemical binding]; other site 43989007714 catalytic triad [active] 43989007715 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 43989007716 metal-binding heat shock protein; Provisional; Region: PRK00016 43989007717 Protein of unknown function (DUF3285); Region: DUF3285; pfam11688 43989007718 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 43989007719 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 43989007720 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989007721 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989007722 putative active site [active] 43989007723 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 43989007724 proline aminopeptidase P II; Provisional; Region: PRK10879 43989007725 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 43989007726 active site 43989007727 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 43989007728 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 43989007729 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 43989007730 choice-of-anchor C domain; Region: choice_anch_C; TIGR04362 43989007731 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 43989007732 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 43989007733 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 43989007734 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 43989007735 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 43989007736 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 43989007737 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 43989007738 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 43989007739 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 43989007740 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 43989007741 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 43989007742 PhoH-like protein; Region: PhoH; pfam02562 43989007743 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 43989007744 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 43989007745 Phycobilisome protein; Region: Phycobilisome; cl08227 43989007746 Phycobilisome protein; Region: Phycobilisome; cl08227 43989007747 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 43989007748 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 43989007749 Walker A motif; other site 43989007750 ATP binding site [chemical binding]; other site 43989007751 Walker B motif; other site 43989007752 trigger factor; Provisional; Region: tig; PRK01490 43989007753 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 43989007754 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 43989007755 Protein of unknown function (DUF552); Region: DUF552; pfam04472 43989007756 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 43989007757 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 43989007758 active site 43989007759 ATP binding site [chemical binding]; other site 43989007760 substrate binding site [chemical binding]; other site 43989007761 activation loop (A-loop); other site 43989007762 HEAT repeats; Region: HEAT_2; pfam13646 43989007763 HEAT repeats; Region: HEAT_2; pfam13646 43989007764 HEAT repeats; Region: HEAT_2; pfam13646 43989007765 HEAT repeats; Region: HEAT_2; pfam13646 43989007766 Domain of unknown function DUF29; Region: DUF29; pfam01724 43989007767 CTP synthetase; Validated; Region: pyrG; PRK05380 43989007768 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 43989007769 Catalytic site [active] 43989007770 active site 43989007771 UTP binding site [chemical binding]; other site 43989007772 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 43989007773 active site 43989007774 putative oxyanion hole; other site 43989007775 catalytic triad [active] 43989007776 heat shock protein 90; Provisional; Region: PRK05218 43989007777 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989007778 ATP binding site [chemical binding]; other site 43989007779 Mg2+ binding site [ion binding]; other site 43989007780 G-X-G motif; other site 43989007781 HEAT repeats; Region: HEAT_2; pfam13646 43989007782 L-aspartate oxidase; Provisional; Region: PRK07395 43989007783 L-aspartate oxidase; Provisional; Region: PRK06175 43989007784 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 43989007785 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989007786 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 43989007787 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989007788 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989007789 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 43989007790 Protein phosphatase 2C; Region: PP2C; pfam00481 43989007791 active site 43989007792 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 43989007793 ADP-glucose phosphorylase; Region: PLN02643 43989007794 nucleotide binding site/active site [active] 43989007795 HIT family signature motif; other site 43989007796 catalytic residue [active] 43989007797 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 43989007798 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 43989007799 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 43989007800 Predicted esterase [General function prediction only]; Region: COG0400 43989007801 putative hydrolase; Provisional; Region: PRK11460 43989007802 dihydrodipicolinate reductase; Provisional; Region: PRK00048 43989007803 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 43989007804 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 43989007805 Predicted permease [General function prediction only]; Region: COG3329 43989007806 Uncharacterized conserved protein [Function unknown]; Region: COG1565 43989007807 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 43989007808 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 43989007809 Catalytic domain of Protein Kinases; Region: PKc; cd00180 43989007810 active site 43989007811 ATP binding site [chemical binding]; other site 43989007812 substrate binding site [chemical binding]; other site 43989007813 activation loop (A-loop); other site 43989007814 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 43989007815 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989007816 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 43989007817 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989007818 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989007819 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 43989007820 Protein export membrane protein; Region: SecD_SecF; cl14618 43989007821 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 43989007822 HlyD family secretion protein; Region: HlyD_3; pfam13437 43989007823 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 43989007824 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 43989007825 TM-ABC transporter signature motif; other site 43989007826 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 43989007827 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 43989007828 Coenzyme A binding pocket [chemical binding]; other site 43989007829 dnd system-associated protein 4; Region: dnd_assoc_4; TIGR04062 43989007830 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 43989007831 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 43989007832 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 43989007833 Catalytic domain of Protein Kinases; Region: PKc; cd00180 43989007834 active site 43989007835 ATP binding site [chemical binding]; other site 43989007836 substrate binding site [chemical binding]; other site 43989007837 activation loop (A-loop); other site 43989007838 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 43989007839 PilZ domain; Region: PilZ; pfam07238 43989007840 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 43989007841 cytochrome c-550; Provisional; Region: psbV; PRK13619 43989007842 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 43989007843 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 43989007844 C-terminal domain interface [polypeptide binding]; other site 43989007845 GSH binding site (G-site) [chemical binding]; other site 43989007846 dimer interface [polypeptide binding]; other site 43989007847 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 43989007848 N-terminal domain interface [polypeptide binding]; other site 43989007849 dimer interface [polypeptide binding]; other site 43989007850 substrate binding pocket (H-site) [chemical binding]; other site 43989007851 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 43989007852 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 43989007853 Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471 43989007854 cytochrome b subunit interaction site [polypeptide binding]; other site 43989007855 [2Fe-2S] cluster binding site [ion binding]; other site 43989007856 apocytochrome f; Reviewed; Region: PRK02693 43989007857 cytochrome f; Region: petA; CHL00037 43989007858 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 43989007859 Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018 43989007860 putative metal binding residues [ion binding]; other site 43989007861 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 43989007862 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 43989007863 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 43989007864 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 43989007865 ABC-ATPase subunit interface; other site 43989007866 dimer interface [polypeptide binding]; other site 43989007867 putative PBP binding regions; other site 43989007868 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 43989007869 Uncharacterized conserved protein [Function unknown]; Region: COG5464 43989007870 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 43989007871 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 43989007872 substrate binding site [chemical binding]; other site 43989007873 active site 43989007874 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 43989007875 diiron binding motif [ion binding]; other site 43989007876 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 43989007877 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 43989007878 NAD binding site [chemical binding]; other site 43989007879 homodimer interface [polypeptide binding]; other site 43989007880 active site 43989007881 substrate binding site [chemical binding]; other site 43989007882 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 43989007883 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 43989007884 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 43989007885 DDE superfamily endonuclease; Region: DDE_3; pfam13358 43989007886 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 43989007887 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 43989007888 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 43989007889 Transposase [DNA replication, recombination, and repair]; Region: COG5433 43989007890 Transposase [DNA replication, recombination, and repair]; Region: COG5433 43989007891 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 43989007892 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 43989007893 dimer interface [polypeptide binding]; other site 43989007894 motif 1; other site 43989007895 active site 43989007896 motif 2; other site 43989007897 motif 3; other site 43989007898 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 43989007899 anticodon binding site; other site 43989007900 DDE superfamily endonuclease; Region: DDE_3; pfam13358 43989007901 Homeodomain-like domain; Region: HTH_23; pfam13384 43989007902 Winged helix-turn helix; Region: HTH_29; pfam13551 43989007903 Homeodomain-like domain; Region: HTH_32; pfam13565 43989007904 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 43989007905 Mechanosensitive ion channel; Region: MS_channel; pfam00924 43989007906 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 43989007907 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 43989007908 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 43989007909 protein binding site [polypeptide binding]; other site 43989007910 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 43989007911 binding surface 43989007912 TPR motif; other site 43989007913 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 43989007914 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 43989007915 TRA-1 regulated protein R03H10.4; Region: TRA-1_regulated; pfam02343 43989007916 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 43989007917 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 43989007918 active site 43989007919 metal binding site [ion binding]; metal-binding site 43989007920 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 43989007921 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 43989007922 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 43989007923 FtsX-like permease family; Region: FtsX; pfam02687 43989007924 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 43989007925 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 43989007926 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 43989007927 HlyD family secretion protein; Region: HlyD_3; pfam13437 43989007928 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 43989007929 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 43989007930 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 43989007931 Methyltransferase domain; Region: Methyltransf_23; pfam13489 43989007932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989007933 S-adenosylmethionine binding site [chemical binding]; other site 43989007934 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 43989007935 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 43989007936 Walker A/P-loop; other site 43989007937 ATP binding site [chemical binding]; other site 43989007938 Q-loop/lid; other site 43989007939 ABC transporter signature motif; other site 43989007940 Walker B; other site 43989007941 D-loop; other site 43989007942 H-loop/switch region; other site 43989007943 ABC transporter; Region: ABC_tran_2; pfam12848 43989007944 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 43989007945 Uncharacterized conserved protein [Function unknown]; Region: COG3937 43989007946 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 43989007947 Low molecular weight phosphatase family; Region: LMWPc; cd00115 43989007948 active site 43989007949 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 43989007950 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 43989007951 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 43989007952 arsenical-resistance protein; Region: acr3; TIGR00832 43989007953 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 43989007954 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 43989007955 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 43989007956 Uncharacterized conserved protein [Function unknown]; Region: COG4279 43989007957 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 43989007958 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 43989007959 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 43989007960 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 43989007961 Protein of unknown function (DUF497); Region: DUF497; pfam04365 43989007962 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 43989007963 endonuclease III; Region: ENDO3c; smart00478 43989007964 minor groove reading motif; other site 43989007965 helix-hairpin-helix signature motif; other site 43989007966 substrate binding pocket [chemical binding]; other site 43989007967 active site 43989007968 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 43989007969 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 43989007970 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 43989007971 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 43989007972 putative ligand binding site [chemical binding]; other site 43989007973 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989007974 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 43989007975 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989007976 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989007977 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989007978 Tetratricopeptide repeat; Region: TPR_16; pfam13432 43989007979 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989007980 binding surface 43989007981 TPR motif; other site 43989007982 Tetratricopeptide repeat; Region: TPR_16; pfam13432 43989007983 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 43989007984 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 43989007985 FMN binding site [chemical binding]; other site 43989007986 active site 43989007987 catalytic residues [active] 43989007988 substrate binding site [chemical binding]; other site 43989007989 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 43989007990 Ligand Binding Site [chemical binding]; other site 43989007991 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 43989007992 Protein of unknown function, DUF482; Region: DUF482; pfam04339 43989007993 RibD C-terminal domain; Region: RibD_C; cl17279 43989007994 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 43989007995 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 43989007996 MarC family integral membrane protein; Region: MarC; cl00919 43989007997 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 43989007998 DNA protecting protein DprA; Region: dprA; TIGR00732 43989007999 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 43989008000 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 43989008001 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 43989008002 intersubunit interface [polypeptide binding]; other site 43989008003 active site 43989008004 catalytic residue [active] 43989008005 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 43989008006 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 43989008007 Uncharacterized conserved protein [Function unknown]; Region: COG3937 43989008008 Beta-lactamase; Region: Beta-lactamase; pfam00144 43989008009 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 43989008010 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 43989008011 flavodoxin FldA; Validated; Region: PRK09267 43989008012 Condensation domain; Region: Condensation; pfam00668 43989008013 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 43989008014 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 43989008015 acyl-activating enzyme (AAE) consensus motif; other site 43989008016 AMP binding site [chemical binding]; other site 43989008017 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 43989008018 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 43989008019 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 43989008020 PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595 43989008021 AMIN domain; Region: AMIN; pfam11741 43989008022 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 43989008023 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 43989008024 N-terminal plug; other site 43989008025 ligand-binding site [chemical binding]; other site 43989008026 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 43989008027 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 43989008028 Walker A/P-loop; other site 43989008029 ATP binding site [chemical binding]; other site 43989008030 Q-loop/lid; other site 43989008031 ABC transporter signature motif; other site 43989008032 Walker B; other site 43989008033 D-loop; other site 43989008034 H-loop/switch region; other site 43989008035 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 43989008036 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 43989008037 Condensation domain; Region: Condensation; pfam00668 43989008038 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 43989008039 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 43989008040 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 43989008041 acyl-activating enzyme (AAE) consensus motif; other site 43989008042 AMP binding site [chemical binding]; other site 43989008043 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 43989008044 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 43989008045 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 43989008046 Predicted membrane protein (DUF2070); Region: DUF2070; pfam09843 43989008047 thioester reductase domain; Region: Thioester-redct; TIGR01746 43989008048 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 43989008049 putative NAD(P) binding site [chemical binding]; other site 43989008050 active site 43989008051 putative substrate binding site [chemical binding]; other site 43989008052 Methyltransferase domain; Region: Methyltransf_31; pfam13847 43989008053 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989008054 S-adenosylmethionine binding site [chemical binding]; other site 43989008055 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 43989008056 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 43989008057 inhibitor-cofactor binding pocket; inhibition site 43989008058 pyridoxal 5'-phosphate binding site [chemical binding]; other site 43989008059 catalytic residue [active] 43989008060 MbtH-like protein; Region: MbtH; cl01279 43989008061 Condensation domain; Region: Condensation; pfam00668 43989008062 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 43989008063 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 43989008064 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 43989008065 acyl-activating enzyme (AAE) consensus motif; other site 43989008066 AMP binding site [chemical binding]; other site 43989008067 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 43989008068 Condensation domain; Region: Condensation; pfam00668 43989008069 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 43989008070 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 43989008071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 43989008072 Major Facilitator Superfamily; Region: MFS_1; pfam07690 43989008073 putative substrate translocation pore; other site 43989008074 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 43989008075 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 43989008076 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 43989008077 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 43989008078 Condensation domain; Region: Condensation; pfam00668 43989008079 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 43989008080 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 43989008081 acyl-activating enzyme (AAE) consensus motif; other site 43989008082 AMP binding site [chemical binding]; other site 43989008083 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 43989008084 Condensation domain; Region: Condensation; pfam00668 43989008085 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 43989008086 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 43989008087 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 43989008088 acyl-activating enzyme (AAE) consensus motif; other site 43989008089 AMP binding site [chemical binding]; other site 43989008090 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 43989008091 Condensation domain; Region: Condensation; pfam00668 43989008092 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 43989008093 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 43989008094 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 43989008095 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 43989008096 Walker A/P-loop; other site 43989008097 ATP binding site [chemical binding]; other site 43989008098 Q-loop/lid; other site 43989008099 ABC transporter signature motif; other site 43989008100 Walker B; other site 43989008101 D-loop; other site 43989008102 H-loop/switch region; other site 43989008103 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 43989008104 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 43989008105 FtsX-like permease family; Region: FtsX; pfam02687 43989008106 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 43989008107 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 43989008108 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 43989008109 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 43989008110 HlyD family secretion protein; Region: HlyD_3; pfam13437 43989008111 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 43989008112 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 43989008113 ligand binding site [chemical binding]; other site 43989008114 flexible hinge region; other site 43989008115 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 43989008116 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 43989008117 putative active site [active] 43989008118 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 43989008119 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 43989008120 Walker A/P-loop; other site 43989008121 ATP binding site [chemical binding]; other site 43989008122 Q-loop/lid; other site 43989008123 ABC transporter signature motif; other site 43989008124 Walker B; other site 43989008125 D-loop; other site 43989008126 H-loop/switch region; other site 43989008127 H+ Antiporter protein; Region: 2A0121; TIGR00900 43989008128 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 43989008129 putative substrate translocation pore; other site 43989008130 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 43989008131 putative dimer interface [polypeptide binding]; other site 43989008132 putative [2Fe-2S] cluster binding site [ion binding]; other site 43989008133 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 43989008134 Predicted RNA binding protein (dsRBD-like fold), HicA family [General function prediction only]; Region: COG1724 43989008135 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 43989008136 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 43989008137 ABC transporter; Region: ABC_tran; pfam00005 43989008138 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 43989008139 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 43989008140 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 43989008141 Protein of unknown function (DUF3102); Region: DUF3102; pfam11300 43989008142 Condensation domain; Region: Condensation; pfam00668 43989008143 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 43989008144 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 43989008145 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 43989008146 acyl-activating enzyme (AAE) consensus motif; other site 43989008147 AMP binding site [chemical binding]; other site 43989008148 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 43989008149 Condensation domain; Region: Condensation; pfam00668 43989008150 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 43989008151 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 43989008152 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 43989008153 acyl-activating enzyme (AAE) consensus motif; other site 43989008154 AMP binding site [chemical binding]; other site 43989008155 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 43989008156 Condensation domain; Region: Condensation; pfam00668 43989008157 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 43989008158 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 43989008159 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989008160 putative active site [active] 43989008161 Condensation domain; Region: Condensation; pfam00668 43989008162 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 43989008163 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 43989008164 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 43989008165 acyl-activating enzyme (AAE) consensus motif; other site 43989008166 AMP binding site [chemical binding]; other site 43989008167 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 43989008168 Condensation domain; Region: Condensation; pfam00668 43989008169 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 43989008170 Nonribosomal peptide synthase; Region: NRPS; pfam08415 43989008171 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 43989008172 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 43989008173 acyl-activating enzyme (AAE) consensus motif; other site 43989008174 AMP binding site [chemical binding]; other site 43989008175 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 43989008176 putative FMN binding site [chemical binding]; other site 43989008177 NADPH bind site [chemical binding]; other site 43989008178 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 43989008179 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 43989008180 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 43989008181 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 43989008182 active site 43989008183 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 43989008184 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 43989008185 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 43989008186 putative NADP binding site [chemical binding]; other site 43989008187 active site 43989008188 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 43989008189 Condensation domain; Region: Condensation; pfam00668 43989008190 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 43989008191 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 43989008192 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 43989008193 acyl-activating enzyme (AAE) consensus motif; other site 43989008194 AMP binding site [chemical binding]; other site 43989008195 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 43989008196 acyl-CoA synthetase; Validated; Region: PRK05850 43989008197 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 43989008198 acyl-activating enzyme (AAE) consensus motif; other site 43989008199 active site 43989008200 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 43989008201 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 43989008202 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 43989008203 active site 43989008204 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 43989008205 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 43989008206 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 43989008207 active site 43989008208 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 43989008209 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 43989008210 Methyltransferase domain; Region: Methyltransf_12; pfam08242 43989008211 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 43989008212 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 43989008213 Enoylreductase; Region: PKS_ER; smart00829 43989008214 NAD(P) binding site [chemical binding]; other site 43989008215 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 43989008216 KR domain; Region: KR; pfam08659 43989008217 putative NADP binding site [chemical binding]; other site 43989008218 active site 43989008219 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 43989008220 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 43989008221 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 43989008222 active site 43989008223 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 43989008224 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 43989008225 Methyltransferase domain; Region: Methyltransf_12; pfam08242 43989008226 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 43989008227 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 43989008228 Enoylreductase; Region: PKS_ER; smart00829 43989008229 NAD(P) binding site [chemical binding]; other site 43989008230 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 43989008231 KR domain; Region: KR; pfam08659 43989008232 putative NADP binding site [chemical binding]; other site 43989008233 active site 43989008234 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 43989008235 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 43989008236 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 43989008237 active site 43989008238 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 43989008239 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 43989008240 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 43989008241 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 43989008242 putative NADP binding site [chemical binding]; other site 43989008243 active site 43989008244 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 43989008245 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 43989008246 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 43989008247 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 43989008248 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 43989008249 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 43989008250 Zn binding site [ion binding]; other site 43989008251 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 43989008252 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 43989008253 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 43989008254 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 43989008255 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989008256 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989008257 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 43989008258 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 43989008259 active site 43989008260 metal binding site [ion binding]; metal-binding site 43989008261 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 43989008262 Domain of unknown function DUF21; Region: DUF21; pfam01595 43989008263 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 43989008264 Transporter associated domain; Region: CorC_HlyC; smart01091 43989008265 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 43989008266 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 43989008267 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 43989008268 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 43989008269 FtsX-like permease family; Region: FtsX; pfam02687 43989008270 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 43989008271 dimer interface [polypeptide binding]; other site 43989008272 substrate binding site [chemical binding]; other site 43989008273 ATP binding site [chemical binding]; other site 43989008274 Bacterial sugar transferase; Region: Bac_transf; pfam02397 43989008275 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 43989008276 Glycoprotease family; Region: Peptidase_M22; pfam00814 43989008277 acetylornithine aminotransferase; Provisional; Region: PRK02627 43989008278 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 43989008279 inhibitor-cofactor binding pocket; inhibition site 43989008280 pyridoxal 5'-phosphate binding site [chemical binding]; other site 43989008281 catalytic residue [active] 43989008282 Tic20-like protein; Region: Tic20; pfam09685 43989008283 phosphate acetyltransferase; Reviewed; Region: PRK05632 43989008284 DRTGG domain; Region: DRTGG; pfam07085 43989008285 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 43989008286 Protein of unknown function (DUF938); Region: DUF938; pfam06080 43989008287 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 43989008288 Aluminium resistance protein; Region: Alum_res; pfam06838 43989008289 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 43989008290 Fatty acid desaturase; Region: FA_desaturase; pfam00487 43989008291 Di-iron ligands [ion binding]; other site 43989008292 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 43989008293 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 43989008294 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989008295 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989008296 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 43989008297 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 43989008298 G1 box; other site 43989008299 putative GEF interaction site [polypeptide binding]; other site 43989008300 GTP/Mg2+ binding site [chemical binding]; other site 43989008301 Switch I region; other site 43989008302 G2 box; other site 43989008303 G3 box; other site 43989008304 Switch II region; other site 43989008305 G4 box; other site 43989008306 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 43989008307 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 43989008308 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 43989008309 putative active site [active] 43989008310 putative NTP binding site [chemical binding]; other site 43989008311 putative nucleic acid binding site [nucleotide binding]; other site 43989008312 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 43989008313 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 43989008314 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 43989008315 active site 43989008316 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 43989008317 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 43989008318 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 43989008319 Protein of unknown function (DUF497); Region: DUF497; cl01108 43989008320 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 43989008321 Protein of unknown function (DUF726); Region: DUF726; pfam05277 43989008322 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12899 43989008323 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 43989008324 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 43989008325 ATP-grasp domain; Region: ATP-grasp_4; cl17255 43989008326 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 43989008327 Na binding site [ion binding]; other site 43989008328 hypothetical protein; Provisional; Region: PRK06849 43989008329 ATP-grasp domain; Region: ATP-grasp_4; cl17255 43989008330 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 43989008331 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 43989008332 S-adenosylmethionine binding site [chemical binding]; other site 43989008333 2-epi-5-epi-valiolone synthase (EEVS); Region: EEVS; cd08199 43989008334 active site 43989008335 metal binding site [ion binding]; metal-binding site 43989008336 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 43989008337 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 43989008338 G1 box; other site 43989008339 GTP/Mg2+ binding site [chemical binding]; other site 43989008340 G2 box; other site 43989008341 Switch I region; other site 43989008342 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 43989008343 G3 box; other site 43989008344 Switch II region; other site 43989008345 G4 box; other site 43989008346 KGK domain; Region: KGK; pfam08872 43989008347 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 43989008348 catalytic triad [active] 43989008349 dimer interface [polypeptide binding]; other site 43989008350 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 43989008351 metal binding site 2 [ion binding]; metal-binding site 43989008352 putative DNA binding helix; other site 43989008353 metal binding site 1 [ion binding]; metal-binding site 43989008354 dimer interface [polypeptide binding]; other site 43989008355 structural Zn2+ binding site [ion binding]; other site 43989008356 Phage P2 GpU; Region: Phage_P2_GpU; cl01391 43989008357 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 43989008358 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 43989008359 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 43989008360 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 43989008361 pyridoxal 5'-phosphate binding site [chemical binding]; other site 43989008362 catalytic residue [active] 43989008363 dsRNA-specific ribonuclease [Transcription]; Region: Rnc; COG0571 43989008364 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 43989008365 dimerization interface [polypeptide binding]; other site 43989008366 active site 43989008367 metal binding site [ion binding]; metal-binding site 43989008368 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 43989008369 dsRNA binding site [nucleotide binding]; other site 43989008370 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 43989008371 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 43989008372 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 43989008373 Protein of unknown function (DUF3011); Region: DUF3011; pfam11218 43989008374 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 43989008375 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 43989008376 putative metal binding site; other site 43989008377 Tetratricopeptide repeat; Region: TPR_12; pfam13424 43989008378 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989008379 binding surface 43989008380 TPR motif; other site 43989008381 TPR repeat; Region: TPR_11; pfam13414 43989008382 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989008383 binding surface 43989008384 TPR repeat; Region: TPR_11; pfam13414 43989008385 TPR motif; other site 43989008386 Tetratricopeptide repeat; Region: TPR_16; pfam13432 43989008387 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 43989008388 lipoyl synthase; Provisional; Region: PRK12928 43989008389 geranylgeranyl reductase; Region: ChlP; TIGR02028 43989008390 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 43989008391 Predicted GTPase [General function prediction only]; Region: COG3596 43989008392 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 43989008393 YfjP GTPase; Region: YfjP; cd11383 43989008394 G1 box; other site 43989008395 Walker A/P-loop; other site 43989008396 GTP/Mg2+ binding site [chemical binding]; other site 43989008397 ATP binding site [chemical binding]; other site 43989008398 Switch I region; other site 43989008399 G2 box; other site 43989008400 Switch II region; other site 43989008401 G3 box; other site 43989008402 G4 box; other site 43989008403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 43989008404 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 43989008405 23S rRNA binding site [nucleotide binding]; other site 43989008406 L21 binding site [polypeptide binding]; other site 43989008407 L13 binding site [polypeptide binding]; other site 43989008408 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 43989008409 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 43989008410 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 43989008411 Ferredoxin thioredoxin reductase variable alpha chain; Region: FeThRed_A; pfam02941 43989008412 YcfA-like protein; Region: YcfA; pfam07927 43989008413 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 43989008414 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 43989008415 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 43989008416 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 43989008417 TM-ABC transporter signature motif; other site 43989008418 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 43989008419 RNB domain; Region: RNB; pfam00773 43989008420 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 43989008421 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 43989008422 C-terminal domain interface [polypeptide binding]; other site 43989008423 active site 43989008424 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 43989008425 active site 43989008426 N-terminal domain interface [polypeptide binding]; other site 43989008427 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 43989008428 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 43989008429 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 43989008430 DNA binding residues [nucleotide binding] 43989008431 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 43989008432 catalytic residues [active] 43989008433 catalytic nucleophile [active] 43989008434 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 43989008435 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 43989008436 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 43989008437 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 43989008438 multimerization interface [polypeptide binding]; other site 43989008439 RbcX protein; Region: RcbX; pfam02341 43989008440 ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040 43989008441 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 43989008442 homodimer interface [polypeptide binding]; other site 43989008443 active site 43989008444 heterodimer interface [polypeptide binding]; other site 43989008445 catalytic residue [active] 43989008446 metal binding site [ion binding]; metal-binding site 43989008447 Haemolysin XhlA; Region: XhlA; pfam10779 43989008448 Dynamin family; Region: Dynamin_N; pfam00350 43989008449 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 43989008450 G1 box; other site 43989008451 GTP/Mg2+ binding site [chemical binding]; other site 43989008452 Switch I region; other site 43989008453 G2 box; other site 43989008454 Switch II region; other site 43989008455 G3 box; other site 43989008456 G4 box; other site 43989008457 G5 box; other site 43989008458 Domain of unknown function (DUF697); Region: DUF697; pfam05128 43989008459 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 43989008460 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 43989008461 DALR anticodon binding domain; Region: DALR_1; smart00836 43989008462 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 43989008463 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 43989008464 non-specific DNA interactions [nucleotide binding]; other site 43989008465 DNA binding site [nucleotide binding] 43989008466 sequence specific DNA binding site [nucleotide binding]; other site 43989008467 putative cAMP binding site [chemical binding]; other site 43989008468 Protein of unknown function (DUF726); Region: DUF726; pfam05277 43989008469 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 43989008470 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 43989008471 catalytic loop [active] 43989008472 iron binding site [ion binding]; other site 43989008473 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 43989008474 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 43989008475 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 43989008476 Walker A/P-loop; other site 43989008477 ATP binding site [chemical binding]; other site 43989008478 Q-loop/lid; other site 43989008479 ABC transporter signature motif; other site 43989008480 Walker B; other site 43989008481 D-loop; other site 43989008482 H-loop/switch region; other site 43989008483 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 43989008484 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 43989008485 putative di-iron ligands [ion binding]; other site 43989008486 sulfite reductase subunit beta; Provisional; Region: PRK13504 43989008487 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 43989008488 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 43989008489 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 43989008490 Catalytic domain of Protein Kinases; Region: PKc; cd00180 43989008491 active site 43989008492 ATP binding site [chemical binding]; other site 43989008493 substrate binding site [chemical binding]; other site 43989008494 activation loop (A-loop); other site 43989008495 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989008496 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 43989008497 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989008498 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 43989008499 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989008500 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989008501 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 43989008502 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 43989008503 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 43989008504 active site 43989008505 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 43989008506 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 43989008507 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 43989008508 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 43989008509 putative dimer interface [polypeptide binding]; other site 43989008510 N-terminal domain interface [polypeptide binding]; other site 43989008511 putative substrate binding pocket (H-site) [chemical binding]; other site 43989008512 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 43989008513 active site 43989008514 dimerization interface [polypeptide binding]; other site 43989008515 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 43989008516 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 43989008517 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 43989008518 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989008519 active site 43989008520 phosphorylation site [posttranslational modification] 43989008521 intermolecular recognition site; other site 43989008522 dimerization interface [polypeptide binding]; other site 43989008523 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 43989008524 DNA binding site [nucleotide binding] 43989008525 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 43989008526 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 43989008527 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 43989008528 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 43989008529 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 43989008530 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 43989008531 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 43989008532 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 43989008533 Chromate transporter; Region: Chromate_transp; pfam02417 43989008534 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 43989008535 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 43989008536 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 43989008537 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 43989008538 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 43989008539 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 43989008540 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 43989008541 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 43989008542 cofactor binding site; other site 43989008543 DNA binding site [nucleotide binding] 43989008544 substrate interaction site [chemical binding]; other site 43989008545 DDE superfamily endonuclease; Region: DDE_3; pfam13358 43989008546 Homeodomain-like domain; Region: HTH_23; pfam13384 43989008547 HaeII restriction endonuclease; Region: RE_HaeII; pfam09554 43989008548 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 43989008549 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 43989008550 isocitrate dehydrogenase; Validated; Region: PRK07362 43989008551 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 43989008552 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 43989008553 putative active site [active] 43989008554 dimerization interface [polypeptide binding]; other site 43989008555 putative tRNAtyr binding site [nucleotide binding]; other site 43989008556 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 43989008557 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 43989008558 CpeS-like protein; Region: CpeS; pfam09367 43989008559 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 43989008560 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 43989008561 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 43989008562 active site 43989008563 Protein of unknown function (DUF3370); Region: DUF3370; pfam11850 43989008564 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989008565 putative active site [active] 43989008566 Class I aldolases; Region: Aldolase_Class_I; cl17187 43989008567 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 43989008568 Protein of unknown function (DUF433); Region: DUF433; pfam04255 43989008569 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 43989008570 Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085 43989008571 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 43989008572 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 43989008573 Clp amino terminal domain; Region: Clp_N; pfam02861 43989008574 Clp amino terminal domain; Region: Clp_N; pfam02861 43989008575 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 43989008576 Walker A motif; other site 43989008577 ATP binding site [chemical binding]; other site 43989008578 Walker B motif; other site 43989008579 arginine finger; other site 43989008580 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 43989008581 Walker A motif; other site 43989008582 ATP binding site [chemical binding]; other site 43989008583 Walker B motif; other site 43989008584 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 43989008585 pantothenate kinase; Reviewed; Region: PRK13331 43989008586 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 43989008587 feedback inhibition sensing region; other site 43989008588 homohexameric interface [polypeptide binding]; other site 43989008589 nucleotide binding site [chemical binding]; other site 43989008590 N-acetyl-L-glutamate binding site [chemical binding]; other site 43989008591 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 43989008592 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 43989008593 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 43989008594 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 43989008595 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 43989008596 Cysteine-rich domain; Region: CCG; pfam02754 43989008597 Cysteine-rich domain; Region: CCG; pfam02754 43989008598 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 43989008599 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 43989008600 NAD(P) binding site [chemical binding]; other site 43989008601 catalytic residues [active] 43989008602 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 43989008603 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 43989008604 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 43989008605 NADP binding site [chemical binding]; other site 43989008606 active site 43989008607 putative substrate binding site [chemical binding]; other site 43989008608 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 43989008609 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 43989008610 NADP-binding site; other site 43989008611 homotetramer interface [polypeptide binding]; other site 43989008612 substrate binding site [chemical binding]; other site 43989008613 homodimer interface [polypeptide binding]; other site 43989008614 active site 43989008615 Bacterial sugar transferase; Region: Bac_transf; pfam02397 43989008616 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 43989008617 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 43989008618 putative ADP-binding pocket [chemical binding]; other site 43989008619 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 43989008620 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 43989008621 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 43989008622 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 43989008623 DXD motif; other site 43989008624 Protein of unknown function (DUF1517); Region: DUF1517; pfam07466 43989008625 CAAX protease self-immunity; Region: Abi; pfam02517 43989008626 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 43989008627 succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12577 43989008628 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 43989008629 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 43989008630 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 43989008631 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 43989008632 Malic enzyme, N-terminal domain; Region: malic; pfam00390 43989008633 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 43989008634 putative NAD(P) binding site [chemical binding]; other site 43989008635 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989008636 putative active site [active] 43989008637 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 43989008638 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 43989008639 active site 43989008640 DDE superfamily endonuclease; Region: DDE_5; cl17874 43989008641 Bacteriophage protein GP30.3; Region: Phage_30_3; cl17603 43989008642 ornithine carbamoyltransferase; Provisional; Region: PRK00779 43989008643 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 43989008644 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 43989008645 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 43989008646 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 43989008647 putative active site [active] 43989008648 putative FMN binding site [chemical binding]; other site 43989008649 putative substrate binding site [chemical binding]; other site 43989008650 6-phosphofructokinase; Provisional; Region: PRK03202 43989008651 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 43989008652 active site 43989008653 ADP/pyrophosphate binding site [chemical binding]; other site 43989008654 dimerization interface [polypeptide binding]; other site 43989008655 allosteric effector site; other site 43989008656 fructose-1,6-bisphosphate binding site; other site 43989008657 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 43989008658 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 43989008659 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 43989008660 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 43989008661 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 43989008662 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 43989008663 Soluble P-type ATPase [General function prediction only]; Region: COG4087 43989008664 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 43989008665 ribosomal protein L32; Validated; Region: rpl32; CHL00152 43989008666 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 43989008667 EF-hand domain pair; Region: EF_hand_5; pfam13499 43989008668 Ca2+ binding site [ion binding]; other site 43989008669 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 43989008670 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 43989008671 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 43989008672 catalytic motif [active] 43989008673 Zn binding site [ion binding]; other site 43989008674 RibD C-terminal domain; Region: RibD_C; cl17279 43989008675 ammonium transporter; Region: amt; TIGR00836 43989008676 Electron transfer DM13; Region: DM13; pfam10517 43989008677 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 43989008678 Cytochrome c; Region: Cytochrom_C; pfam00034 43989008679 Cytochrome B6-F complex subunit 5; Region: PetG; pfam02529 43989008680 GMP synthase; Reviewed; Region: guaA; PRK00074 43989008681 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 43989008682 AMP/PPi binding site [chemical binding]; other site 43989008683 candidate oxyanion hole; other site 43989008684 catalytic triad [active] 43989008685 potential glutamine specificity residues [chemical binding]; other site 43989008686 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 43989008687 ATP Binding subdomain [chemical binding]; other site 43989008688 Ligand Binding sites [chemical binding]; other site 43989008689 Dimerization subdomain; other site 43989008690 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 43989008691 SmpB-tmRNA interface; other site 43989008692 VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457 43989008693 metal ion-dependent adhesion site (MIDAS); other site 43989008694 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989008695 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 43989008696 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989008697 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989008698 CHRD domain; Region: CHRD; pfam07452 43989008699 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 43989008700 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 43989008701 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 43989008702 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 43989008703 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 43989008704 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 43989008705 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 43989008706 DDE superfamily endonuclease; Region: DDE_4; pfam13359 43989008707 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 43989008708 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 43989008709 substrate binding site [chemical binding]; other site 43989008710 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 43989008711 substrate binding site [chemical binding]; other site 43989008712 ligand binding site [chemical binding]; other site 43989008713 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 43989008714 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 43989008715 Transposase [DNA replication, recombination, and repair]; Region: COG5433 43989008716 Transposase [DNA replication, recombination, and repair]; Region: COG5433 43989008717 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 43989008718 Protein of unknown function (DUF433); Region: DUF433; pfam04255 43989008719 XisH protein; Region: XisH; pfam08814 43989008720 XisI protein; Region: XisI; pfam08869 43989008721 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 43989008722 Ligand Binding Site [chemical binding]; other site 43989008723 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 43989008724 imidazoleglycerol-phosphate dehydratase; Region: PLN02800 43989008725 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 43989008726 putative active site pocket [active] 43989008727 4-fold oligomerization interface [polypeptide binding]; other site 43989008728 metal binding residues [ion binding]; metal-binding site 43989008729 3-fold/trimer interface [polypeptide binding]; other site 43989008730 glucosylglycerol 3-phosphatase; Region: salt_tol_Pase; TIGR02399 43989008731 Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase); Region: Salt_tol_Pase; pfam09506 43989008732 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 43989008733 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 43989008734 pyridoxal 5'-phosphate binding site [chemical binding]; other site 43989008735 homodimer interface [polypeptide binding]; other site 43989008736 catalytic residue [active] 43989008737 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 43989008738 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 43989008739 active site 43989008740 Protein of unknown function (DUF4090); Region: DUF4090; pfam13319 43989008741 Protein of unknown function (DUF328); Region: DUF328; pfam03883 43989008742 Domain of unknown function DUF29; Region: DUF29; pfam01724 43989008743 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 43989008744 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 43989008745 Walker A/P-loop; other site 43989008746 ATP binding site [chemical binding]; other site 43989008747 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 43989008748 Q-loop/lid; other site 43989008749 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 43989008750 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 43989008751 ABC transporter signature motif; other site 43989008752 Walker B; other site 43989008753 D-loop; other site 43989008754 H-loop/switch region; other site 43989008755 Helix-turn-helix domain; Region: HTH_25; pfam13413 43989008756 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 43989008757 Protein of unknown function (DUF2488); Region: Ycf54; pfam10674 43989008758 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 43989008759 active site 43989008760 hydrophilic channel; other site 43989008761 dimerization interface [polypeptide binding]; other site 43989008762 catalytic residues [active] 43989008763 active site lid [active] 43989008764 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 43989008765 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 43989008766 Coenzyme A binding pocket [chemical binding]; other site 43989008767 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989008768 putative active site [active] 43989008769 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 43989008770 Ligand binding site; other site 43989008771 Putative Catalytic site; other site 43989008772 DXD motif; other site 43989008773 DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096 43989008774 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989008775 putative active site [active] 43989008776 DDE superfamily endonuclease; Region: DDE_4; pfam13359 43989008777 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 43989008778 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 43989008779 AAA domain; Region: AAA_23; pfam13476 43989008780 Walker A/P-loop; other site 43989008781 ATP binding site [chemical binding]; other site 43989008782 Protein of unknown function (DUF2393); Region: DUF2393; pfam09624 43989008783 TIGR02588 family protein; Region: TIGR02588 43989008784 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 43989008785 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 43989008786 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 43989008787 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 43989008788 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 43989008789 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 43989008790 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 43989008791 [2Fe-2S] cluster binding site [ion binding]; other site 43989008792 Putative integral membrane protein (DUF2391); Region: DUF2391; cl01935 43989008793 Uncharacterized conserved protein [Function unknown]; Region: COG1432 43989008794 LabA_like proteins; Region: LabA; cd10911 43989008795 putative metal binding site [ion binding]; other site 43989008796 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 43989008797 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 43989008798 active site residue [active] 43989008799 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 43989008800 active site residue [active] 43989008801 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 43989008802 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 43989008803 ATP binding site [chemical binding]; other site 43989008804 Mg2+ binding site [ion binding]; other site 43989008805 G-X-G motif; other site 43989008806 Response regulator receiver domain; Region: Response_reg; pfam00072 43989008807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989008808 active site 43989008809 phosphorylation site [posttranslational modification] 43989008810 intermolecular recognition site; other site 43989008811 dimerization interface [polypeptide binding]; other site 43989008812 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 43989008813 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 43989008814 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 43989008815 anti sigma factor interaction site; other site 43989008816 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 43989008817 regulatory phosphorylation site [posttranslational modification]; other site 43989008818 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 43989008819 RNA/DNA hybrid binding site [nucleotide binding]; other site 43989008820 active site 43989008821 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 43989008822 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 43989008823 RNA binding surface [nucleotide binding]; other site 43989008824 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 43989008825 active site 43989008826 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 43989008827 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 43989008828 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 43989008829 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989008830 phosphorylation site [posttranslational modification] 43989008831 dimer interface [polypeptide binding]; other site 43989008832 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989008833 ATP binding site [chemical binding]; other site 43989008834 Mg2+ binding site [ion binding]; other site 43989008835 G-X-G motif; other site 43989008836 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 43989008837 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 43989008838 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 43989008839 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 43989008840 ring oligomerisation interface [polypeptide binding]; other site 43989008841 ATP/Mg binding site [chemical binding]; other site 43989008842 stacking interactions; other site 43989008843 hinge regions; other site 43989008844 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 43989008845 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 43989008846 active site 43989008847 metal binding site [ion binding]; metal-binding site 43989008848 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 43989008849 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 43989008850 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 43989008851 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 43989008852 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 43989008853 active site 43989008854 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 43989008855 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 43989008856 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 43989008857 NADP-binding site; other site 43989008858 homotetramer interface [polypeptide binding]; other site 43989008859 substrate binding site [chemical binding]; other site 43989008860 homodimer interface [polypeptide binding]; other site 43989008861 active site 43989008862 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 43989008863 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 43989008864 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 43989008865 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 43989008866 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 43989008867 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 43989008868 XdhC Rossmann domain; Region: XdhC_C; pfam13478 43989008869 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 43989008870 Ligand binding site; other site 43989008871 metal-binding site 43989008872 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 43989008873 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 43989008874 peptide binding site [polypeptide binding]; other site 43989008875 dimer interface [polypeptide binding]; other site 43989008876 Tetratricopeptide repeat; Region: TPR_12; pfam13424 43989008877 Tetratricopeptide repeat; Region: TPR_12; pfam13424 43989008878 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989008879 binding surface 43989008880 TPR motif; other site 43989008881 Tetratricopeptide repeat; Region: TPR_12; pfam13424 43989008882 light-harvesting-like protein 3; Provisional; Region: PLN00014 43989008883 Exoribonuclease R [Transcription]; Region: VacB; COG0557 43989008884 RNB domain; Region: RNB; pfam00773 43989008885 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 43989008886 ribosomal protein L33; Region: rpl33; CHL00104 43989008887 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 43989008888 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 43989008889 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 43989008890 Ligand binding site; other site 43989008891 Putative Catalytic site; other site 43989008892 DXD motif; other site 43989008893 coenzyme F420-reducing hydrogenase subunit beta; Validated; Region: PRK09325 43989008894 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 43989008895 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 43989008896 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 43989008897 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 43989008898 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 43989008899 catalytic triad [active] 43989008900 cobyric acid synthase; Provisional; Region: PRK00784 43989008901 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 43989008902 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 43989008903 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 43989008904 catalytic triad [active] 43989008905 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 43989008906 catalytic loop [active] 43989008907 iron binding site [ion binding]; other site 43989008908 Predicted dehydrogenase [General function prediction only]; Region: COG0579 43989008909 hydroxyglutarate oxidase; Provisional; Region: PRK11728 43989008910 Domain of unknown function (DUF1825); Region: DUF1825; pfam08855 43989008911 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 43989008912 Short C-terminal domain; Region: SHOCT; pfam09851 43989008913 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 43989008914 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 43989008915 putative hydrophobic ligand binding site [chemical binding]; other site 43989008916 3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396 43989008917 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 43989008918 Protein of unknown function (DUF433); Region: DUF433; pfam04255 43989008919 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 43989008920 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 43989008921 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 43989008922 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 43989008923 tandem repeat interface [polypeptide binding]; other site 43989008924 oligomer interface [polypeptide binding]; other site 43989008925 active site residues [active] 43989008926 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 43989008927 homotrimer interaction site [polypeptide binding]; other site 43989008928 active site 43989008929 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 43989008930 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 43989008931 P-loop; other site 43989008932 Magnesium ion binding site [ion binding]; other site 43989008933 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 43989008934 Magnesium ion binding site [ion binding]; other site 43989008935 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 43989008936 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 43989008937 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 43989008938 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 43989008939 hypothetical protein; Region: PHA02030 43989008940 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 43989008941 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989008942 active site 43989008943 phosphorylation site [posttranslational modification] 43989008944 intermolecular recognition site; other site 43989008945 dimerization interface [polypeptide binding]; other site 43989008946 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 43989008947 DNA binding site [nucleotide binding] 43989008948 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 43989008949 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989008950 dimer interface [polypeptide binding]; other site 43989008951 phosphorylation site [posttranslational modification] 43989008952 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989008953 ATP binding site [chemical binding]; other site 43989008954 Mg2+ binding site [ion binding]; other site 43989008955 G-X-G motif; other site 43989008956 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 43989008957 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 43989008958 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 43989008959 active site 43989008960 NTP binding site [chemical binding]; other site 43989008961 metal binding triad [ion binding]; metal-binding site 43989008962 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 43989008963 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 43989008964 Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718 43989008965 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 43989008966 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 43989008967 ligand binding site [chemical binding]; other site 43989008968 flexible hinge region; other site 43989008969 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 43989008970 HEAT repeats; Region: HEAT_2; pfam13646 43989008971 HEAT repeats; Region: HEAT_2; pfam13646 43989008972 HEAT repeats; Region: HEAT_2; pfam13646 43989008973 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 43989008974 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 43989008975 FIST N domain; Region: FIST; smart00897 43989008976 FIST C domain; Region: FIST_C; pfam10442 43989008977 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 43989008978 KH domain; Region: KH_4; pfam13083 43989008979 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 43989008980 ribosomal protein S16; Region: rps16; CHL00005 43989008981 Protein of unknown function (DUF3769); Region: DUF3769; pfam12600 43989008982 photosystem II reaction center I protein I; Provisional; Region: psbI; PRK02655 43989008983 NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909 43989008984 glycogen synthase; Provisional; Region: glgA; PRK00654 43989008985 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 43989008986 ADP-binding pocket [chemical binding]; other site 43989008987 homodimer interface [polypeptide binding]; other site 43989008988 Domain of unknown function (DUF309); Region: DUF309; pfam03745 43989008989 ferredoxin thioreductase subunit beta; Validated; Region: ftrB; CHL00165 43989008990 Domain of unknown function (DUF389); Region: DUF389; pfam04087 43989008991 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 43989008992 anthranilate synthase component I-like protein; Validated; Region: PRK05940 43989008993 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 43989008994 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 43989008995 TMAO/DMSO reductase; Reviewed; Region: PRK05363 43989008996 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 43989008997 Moco binding site; other site 43989008998 metal coordination site [ion binding]; other site 43989008999 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 43989009000 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 43989009001 replicative DNA helicase; Region: DnaB; TIGR00665 43989009002 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 43989009003 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 43989009004 Walker A motif; other site 43989009005 ATP binding site [chemical binding]; other site 43989009006 Walker B motif; other site 43989009007 DNA binding loops [nucleotide binding] 43989009008 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 43989009009 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 43989009010 putative NAD(P) binding site [chemical binding]; other site 43989009011 putative active site [active] 43989009012 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 43989009013 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 43989009014 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 43989009015 active site residue [active] 43989009016 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 43989009017 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 43989009018 Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471 43989009019 cytochrome b subunit interaction site [polypeptide binding]; other site 43989009020 [2Fe-2S] cluster binding site [ion binding]; other site 43989009021 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 43989009022 pheophytin binding site; other site 43989009023 chlorophyll binding site; other site 43989009024 quinone binding site; other site 43989009025 Fe binding site [ion binding]; other site 43989009026 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB2; cd01048 43989009027 diiron binding motif [ion binding]; other site 43989009028 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 43989009029 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 43989009030 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 43989009031 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 43989009032 ABC1 family; Region: ABC1; cl17513 43989009033 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 43989009034 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 43989009035 Walker A/P-loop; other site 43989009036 ATP binding site [chemical binding]; other site 43989009037 Q-loop/lid; other site 43989009038 ABC transporter signature motif; other site 43989009039 Walker B; other site 43989009040 D-loop; other site 43989009041 H-loop/switch region; other site 43989009042 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 43989009043 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 43989009044 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 43989009045 pyruvate kinase; Provisional; Region: PRK06354 43989009046 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 43989009047 domain interfaces; other site 43989009048 active site 43989009049 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 43989009050 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 43989009051 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 43989009052 NAD binding site [chemical binding]; other site 43989009053 putative substrate binding site 2 [chemical binding]; other site 43989009054 putative substrate binding site 1 [chemical binding]; other site 43989009055 active site 43989009056 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 43989009057 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 43989009058 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 43989009059 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 43989009060 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 43989009061 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 43989009062 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 43989009063 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 43989009064 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 43989009065 anti sigma factor interaction site; other site 43989009066 regulatory phosphorylation site [posttranslational modification]; other site 43989009067 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 43989009068 Bacterial sugar transferase; Region: Bac_transf; pfam02397 43989009069 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 43989009070 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 43989009071 Peptidase family M50; Region: Peptidase_M50; pfam02163 43989009072 active site 43989009073 putative substrate binding region [chemical binding]; other site 43989009074 FOG: CBS domain [General function prediction only]; Region: COG0517 43989009075 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 43989009076 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 43989009077 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 43989009078 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 43989009079 Ycf46; Provisional; Region: ycf46; CHL00195 43989009080 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 43989009081 Walker A motif; other site 43989009082 ATP binding site [chemical binding]; other site 43989009083 Walker B motif; other site 43989009084 arginine finger; other site 43989009085 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 43989009086 catalytic core [active] 43989009087 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 43989009088 intracellular protease, PfpI family; Region: PfpI; TIGR01382 43989009089 proposed catalytic triad [active] 43989009090 conserved cys residue [active] 43989009091 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 43989009092 dinuclear metal binding motif [ion binding]; other site 43989009093 Predicted permease [General function prediction only]; Region: COG2985 43989009094 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 43989009095 TrkA-C domain; Region: TrkA_C; pfam02080 43989009096 TrkA-C domain; Region: TrkA_C; pfam02080 43989009097 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 43989009098 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989009099 S-adenosylmethionine binding site [chemical binding]; other site 43989009100 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 43989009101 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 43989009102 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 43989009103 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 43989009104 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989009105 putative active site [active] 43989009106 Domain of unknown function DUF29; Region: DUF29; pfam01724 43989009107 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 43989009108 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989009109 putative active site [active] 43989009110 Protein of unknown function (DUF1626); Region: DUF1626; pfam07788 43989009111 Uncharacterized conserved protein [Function unknown]; Region: COG5464 43989009112 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 43989009113 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 43989009114 CsbD-like; Region: CsbD; pfam05532 43989009115 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 43989009116 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 43989009117 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 43989009118 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 43989009119 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 43989009120 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 43989009121 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 43989009122 putative ADP-binding pocket [chemical binding]; other site 43989009123 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 43989009124 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 43989009125 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 43989009126 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 43989009127 RNA binding site [nucleotide binding]; other site 43989009128 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 43989009129 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 43989009130 dimer interface [polypeptide binding]; other site 43989009131 putative anticodon binding site; other site 43989009132 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 43989009133 motif 1; other site 43989009134 active site 43989009135 motif 2; other site 43989009136 motif 3; other site 43989009137 KTSC domain; Region: KTSC; pfam13619 43989009138 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 43989009139 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 43989009140 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 43989009141 active site 43989009142 catalytic site [active] 43989009143 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 43989009144 Probable transposase; Region: OrfB_IS605; pfam01385 43989009145 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 43989009146 Transposase IS200 like; Region: Y1_Tnp; pfam01797 43989009147 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 43989009148 dimerization interface [polypeptide binding]; other site 43989009149 putative DNA binding site [nucleotide binding]; other site 43989009150 putative Zn2+ binding site [ion binding]; other site 43989009151 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 43989009152 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 43989009153 active site residue [active] 43989009154 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 43989009155 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 43989009156 signal recognition particle protein; Provisional; Region: PRK10867 43989009157 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 43989009158 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 43989009159 P loop; other site 43989009160 GTP binding site [chemical binding]; other site 43989009161 Signal peptide binding domain; Region: SRP_SPB; pfam02978 43989009162 Helix-turn-helix domain; Region: HTH_17; pfam12728 43989009163 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 43989009164 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 43989009165 cofactor binding site; other site 43989009166 DNA binding site [nucleotide binding] 43989009167 substrate interaction site [chemical binding]; other site 43989009168 SinI restriction endonuclease; Region: RE_SinI; pfam09570 43989009169 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 43989009170 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 43989009171 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 43989009172 NAD(P) binding site [chemical binding]; other site 43989009173 active site 43989009174 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 43989009175 pheophytin binding site; other site 43989009176 chlorophyll binding site; other site 43989009177 quinone binding site; other site 43989009178 Fe binding site [ion binding]; other site 43989009179 Homeodomain-like domain; Region: HTH_23; pfam13384 43989009180 Winged helix-turn helix; Region: HTH_29; pfam13551 43989009181 Winged helix-turn helix; Region: HTH_33; pfam13592 43989009182 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 43989009183 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 43989009184 Transposase [DNA replication, recombination, and repair]; Region: COG5433 43989009185 Transposase [DNA replication, recombination, and repair]; Region: COG5433 43989009186 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 43989009187 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 43989009188 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 43989009189 Sulfate transporter family; Region: Sulfate_transp; pfam00916 43989009190 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 43989009191 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 43989009192 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 43989009193 Ca binding site [ion binding]; other site 43989009194 active site 43989009195 catalytic site [active] 43989009196 TIGR03790 family protein; Region: TIGR03790 43989009197 Phospholipid methyltransferase; Region: PEMT; pfam04191 43989009198 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 43989009199 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 43989009200 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 43989009201 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 43989009202 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 43989009203 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 43989009204 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 43989009205 DNA binding site [nucleotide binding] 43989009206 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 43989009207 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 43989009208 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 43989009209 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 43989009210 RPB1 interaction site [polypeptide binding]; other site 43989009211 RPB10 interaction site [polypeptide binding]; other site 43989009212 RPB11 interaction site [polypeptide binding]; other site 43989009213 RPB3 interaction site [polypeptide binding]; other site 43989009214 RPB12 interaction site [polypeptide binding]; other site 43989009215 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 43989009216 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 43989009217 active site 43989009218 ribosomal protein S20; Region: rps20; CHL00102 43989009219 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 43989009220 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 43989009221 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 43989009222 active site 43989009223 metal binding site [ion binding]; metal-binding site 43989009224 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 43989009225 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 43989009226 active site 43989009227 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 43989009228 active site 43989009229 dimer interface [polypeptide binding]; other site 43989009230 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 43989009231 active site 43989009232 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 43989009233 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 43989009234 putative active site [active] 43989009235 catalytic site [active] 43989009236 putative metal binding site [ion binding]; other site 43989009237 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 43989009238 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 43989009239 Phytase; Region: Phytase; cl17685 43989009240 PhoD-like phosphatase; Region: PhoD; pfam09423 43989009241 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 43989009242 putative active site [active] 43989009243 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 43989009244 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 43989009245 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 43989009246 proposed catalytic triad [active] 43989009247 active site nucleophile [active] 43989009248 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 43989009249 Protein-arginine deiminase (PAD) middle domain; Region: PAD_M; pfam08527 43989009250 Protein-arginine deiminase (PAD); Region: PAD; pfam03068 43989009251 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 43989009252 Ca2+ binding site [ion binding]; other site 43989009253 EF-hand domain pair; Region: EF_hand_5; pfam13499 43989009254 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 43989009255 Ca2+ binding site [ion binding]; other site 43989009256 EF-hand domain pair; Region: EF_hand_5; pfam13499 43989009257 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 43989009258 protein I interface; other site 43989009259 D2 interface; other site 43989009260 protein T interface; other site 43989009261 chlorophyll binding site; other site 43989009262 beta carotene binding site; other site 43989009263 pheophytin binding site; other site 43989009264 manganese-stabilizing polypeptide interface; other site 43989009265 CP43 interface; other site 43989009266 protein L interface; other site 43989009267 oxygen evolving complex binding site; other site 43989009268 bromide binding site; other site 43989009269 quinone binding site; other site 43989009270 Fe binding site [ion binding]; other site 43989009271 core light harvesting interface; other site 43989009272 cytochrome b559 alpha subunit interface; other site 43989009273 cytochrome c-550 interface; other site 43989009274 protein J interface; other site 43989009275 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 43989009276 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 43989009277 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 43989009278 Walker A/P-loop; other site 43989009279 ATP binding site [chemical binding]; other site 43989009280 Q-loop/lid; other site 43989009281 ABC transporter signature motif; other site 43989009282 Walker B; other site 43989009283 D-loop; other site 43989009284 H-loop/switch region; other site 43989009285 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 43989009286 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 43989009287 substrate binding site [chemical binding]; other site 43989009288 ligand binding site [chemical binding]; other site 43989009289 Bacterial Ig-like domain; Region: Big_5; pfam13205 43989009290 TIGR03943 family protein; Region: TIGR03943 43989009291 Predicted permeases [General function prediction only]; Region: COG0701 43989009292 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 43989009293 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 43989009294 catalytic loop [active] 43989009295 iron binding site [ion binding]; other site 43989009296 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 43989009297 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 43989009298 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 43989009299 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 43989009300 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 43989009301 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 43989009302 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 43989009303 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 43989009304 metal binding site [ion binding]; metal-binding site 43989009305 active site 43989009306 I-site; other site 43989009307 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 43989009308 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 43989009309 Coenzyme A binding pocket [chemical binding]; other site 43989009310 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 43989009311 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 43989009312 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 43989009313 NAD(P) binding site [chemical binding]; other site 43989009314 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 43989009315 NADH(P)-binding; Region: NAD_binding_10; pfam13460 43989009316 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 43989009317 active site 43989009318 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 43989009319 AAA domain; Region: AAA_26; pfam13500 43989009320 S-layer homology domain; Region: SLH; pfam00395 43989009321 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 43989009322 S-layer homology domain; Region: SLH; pfam00395 43989009323 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 43989009324 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 43989009325 PhoU domain; Region: PhoU; pfam01895 43989009326 PhoU domain; Region: PhoU; pfam01895 43989009327 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 43989009328 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989009329 dimer interface [polypeptide binding]; other site 43989009330 phosphorylation site [posttranslational modification] 43989009331 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989009332 ATP binding site [chemical binding]; other site 43989009333 Mg2+ binding site [ion binding]; other site 43989009334 G-X-G motif; other site 43989009335 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 43989009336 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 43989009337 active site 43989009338 catalytic site [active] 43989009339 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 43989009340 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 43989009341 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 43989009342 putative hexamer interface [polypeptide binding]; other site 43989009343 putative hexagonal pore; other site 43989009344 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 43989009345 Hexamer interface [polypeptide binding]; other site 43989009346 Hexagonal pore residue; other site 43989009347 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 43989009348 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 43989009349 Walker A/P-loop; other site 43989009350 ATP binding site [chemical binding]; other site 43989009351 Q-loop/lid; other site 43989009352 ABC transporter signature motif; other site 43989009353 Walker B; other site 43989009354 D-loop; other site 43989009355 H-loop/switch region; other site 43989009356 hydrolase, alpha/beta fold family protein; Region: PLN02824 43989009357 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 43989009358 Transglycosylase; Region: Transgly; pfam00912 43989009359 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 43989009360 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 43989009361 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 43989009362 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 43989009363 FAD binding site [chemical binding]; other site 43989009364 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 43989009365 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 43989009366 active site 43989009367 HIGH motif; other site 43989009368 dimer interface [polypeptide binding]; other site 43989009369 KMSKS motif; other site 43989009370 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 43989009371 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 43989009372 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 43989009373 Walker A motif; other site 43989009374 ATP binding site [chemical binding]; other site 43989009375 Walker B motif; other site 43989009376 arginine finger; other site 43989009377 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 43989009378 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 43989009379 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 43989009380 active site 43989009381 dinuclear metal binding site [ion binding]; other site 43989009382 dimerization interface [polypeptide binding]; other site 43989009383 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 43989009384 Protein of unknown function (DUF3747); Region: DUF3747; pfam12565 43989009385 Sporulation related domain; Region: SPOR; pfam05036 43989009386 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 43989009387 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 43989009388 active site 43989009389 catalytic triad [active] 43989009390 oxyanion hole [active] 43989009391 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 43989009392 amidase; Provisional; Region: PRK09201 43989009393 Amidase; Region: Amidase; cl11426 43989009394 Methyltransferase domain; Region: Methyltransf_23; pfam13489 43989009395 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989009396 S-adenosylmethionine binding site [chemical binding]; other site 43989009397 yiaA/B two helix domain; Region: YiaAB; cl01759 43989009398 Methyltransferase domain; Region: Methyltransf_24; pfam13578 43989009399 Homeodomain-like domain; Region: HTH_23; pfam13384 43989009400 DDE superfamily endonuclease; Region: DDE_3; pfam13358 43989009401 Taspase1_like domains; Taspase1 catalyzes the cleavage of the mix lineage leukemia (MLL) nuclear protein and transcription factor TFIIA. Taspase1 is a threonine aspartase, a member of the Ntn hydrolase superfamily and the type 2 asparaginase family. A...; Region: Taspase1_like; cd04514 43989009402 active site 43989009403 dimer interface [polypeptide binding]; other site 43989009404 catalytic nucleophile [active] 43989009405 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 43989009406 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 43989009407 putative DNA binding site [nucleotide binding]; other site 43989009408 putative Zn2+ binding site [ion binding]; other site 43989009409 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989009410 active site 43989009411 phosphorylation site [posttranslational modification] 43989009412 intermolecular recognition site; other site 43989009413 dimerization interface [polypeptide binding]; other site 43989009414 HAMP domain; Region: HAMP; pfam00672 43989009415 PAS domain S-box; Region: sensory_box; TIGR00229 43989009416 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989009417 putative active site [active] 43989009418 heme pocket [chemical binding]; other site 43989009419 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 43989009420 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989009421 putative active site [active] 43989009422 heme pocket [chemical binding]; other site 43989009423 PAS domain; Region: PAS_8; pfam13188 43989009424 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 43989009425 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989009426 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 43989009427 putative active site [active] 43989009428 heme pocket [chemical binding]; other site 43989009429 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989009430 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 43989009431 putative active site [active] 43989009432 heme pocket [chemical binding]; other site 43989009433 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989009434 putative active site [active] 43989009435 heme pocket [chemical binding]; other site 43989009436 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989009437 putative active site [active] 43989009438 heme pocket [chemical binding]; other site 43989009439 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 43989009440 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989009441 putative active site [active] 43989009442 heme pocket [chemical binding]; other site 43989009443 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989009444 dimer interface [polypeptide binding]; other site 43989009445 phosphorylation site [posttranslational modification] 43989009446 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989009447 ATP binding site [chemical binding]; other site 43989009448 Mg2+ binding site [ion binding]; other site 43989009449 G-X-G motif; other site 43989009450 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 43989009451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989009452 active site 43989009453 phosphorylation site [posttranslational modification] 43989009454 intermolecular recognition site; other site 43989009455 dimerization interface [polypeptide binding]; other site 43989009456 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 43989009457 DNA binding site [nucleotide binding] 43989009458 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 43989009459 putative binding surface; other site 43989009460 active site 43989009461 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 43989009462 active site 43989009463 dimerization interface [polypeptide binding]; other site 43989009464 Response regulator receiver domain; Region: Response_reg; pfam00072 43989009465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989009466 active site 43989009467 phosphorylation site [posttranslational modification] 43989009468 intermolecular recognition site; other site 43989009469 dimerization interface [polypeptide binding]; other site 43989009470 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989009471 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 43989009472 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989009473 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 43989009474 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989009475 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989009476 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 43989009477 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989009478 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 43989009479 Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651 43989009480 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 43989009481 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 43989009482 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 43989009483 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989009484 putative active site [active] 43989009485 Mitochondrial carrier protein; Region: Mito_carr; pfam00153 43989009486 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 43989009487 phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816 43989009488 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 43989009489 Phycobilisome protein; Region: Phycobilisome; cl08227 43989009490 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 43989009491 structural tetrad; other site 43989009492 FOG: WD40 repeat [General function prediction only]; Region: COG2319 43989009493 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 43989009494 structural tetrad; other site 43989009495 WD40 repeats; Region: WD40; smart00320 43989009496 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 43989009497 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 43989009498 arginine-tRNA ligase; Region: PLN02286 43989009499 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 43989009500 active site 43989009501 HIGH motif; other site 43989009502 KMSK motif region; other site 43989009503 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 43989009504 tRNA binding surface [nucleotide binding]; other site 43989009505 anticodon binding site; other site 43989009506 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 43989009507 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 43989009508 metal binding site [ion binding]; metal-binding site 43989009509 active site 43989009510 I-site; other site 43989009511 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 43989009512 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 43989009513 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 43989009514 Walker A motif; other site 43989009515 ATP binding site [chemical binding]; other site 43989009516 Walker B motif; other site 43989009517 arginine finger; other site 43989009518 Peptidase family M41; Region: Peptidase_M41; pfam01434 43989009519 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 43989009520 FOG: WD40 repeat [General function prediction only]; Region: COG2319 43989009521 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 43989009522 structural tetrad; other site 43989009523 light-harvesting-like protein 3; Provisional; Region: PLN00014 43989009524 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 43989009525 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 43989009526 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 43989009527 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 43989009528 DNA binding residues [nucleotide binding] 43989009529 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 43989009530 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 43989009531 putative NAD(P) binding site [chemical binding]; other site 43989009532 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 43989009533 classical (c) SDRs; Region: SDR_c; cd05233 43989009534 NAD(P) binding site [chemical binding]; other site 43989009535 active site 43989009536 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 43989009537 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 43989009538 putative ADP-binding pocket [chemical binding]; other site 43989009539 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 43989009540 putative nucleotide binding site [chemical binding]; other site 43989009541 uridine monophosphate binding site [chemical binding]; other site 43989009542 homohexameric interface [polypeptide binding]; other site 43989009543 ribosome recycling factor; Reviewed; Region: frr; PRK00083 43989009544 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 43989009545 hinge region; other site 43989009546 cytosine deaminase-like protein; Validated; Region: PRK07583 43989009547 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 43989009548 active site 43989009549 RNA polymerase sigma factor SigD; Validated; Region: PRK07405 43989009550 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 43989009551 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 43989009552 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 43989009553 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 43989009554 DNA binding residues [nucleotide binding] 43989009555 Protein of unknown function (DUF760); Region: DUF760; pfam05542 43989009556 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 43989009557 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 43989009558 minor groove reading motif; other site 43989009559 helix-hairpin-helix signature motif; other site 43989009560 substrate binding pocket [chemical binding]; other site 43989009561 active site 43989009562 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 43989009563 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 43989009564 active site 43989009565 8-oxo-dGMP binding site [chemical binding]; other site 43989009566 nudix motif; other site 43989009567 metal binding site [ion binding]; metal-binding site 43989009568 na(+)/h(+) antiporter; Region: c_cpa1; TIGR00844 43989009569 Ion channel; Region: Ion_trans_2; pfam07885 43989009570 Predicted membrane protein [Function unknown]; Region: COG2323 43989009571 short chain dehydrogenase; Provisional; Region: PRK06701 43989009572 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 43989009573 NAD binding site [chemical binding]; other site 43989009574 metal binding site [ion binding]; metal-binding site 43989009575 active site 43989009576 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 43989009577 dimer interface [polypeptide binding]; other site 43989009578 catalytic triad [active] 43989009579 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 43989009580 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 43989009581 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 43989009582 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 43989009583 putative phosphoketolase; Provisional; Region: PRK05261 43989009584 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 43989009585 TPP-binding site; other site 43989009586 XFP C-terminal domain; Region: XFP_C; pfam09363 43989009587 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 43989009588 putative active site [active] 43989009589 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 43989009590 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 43989009591 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 43989009592 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 43989009593 Catalytic domain of Protein Kinases; Region: PKc; cd00180 43989009594 active site 43989009595 ATP binding site [chemical binding]; other site 43989009596 substrate binding site [chemical binding]; other site 43989009597 activation loop (A-loop); other site 43989009598 Catalytic domain of Protein Kinases; Region: PKc; cd00180 43989009599 active site 43989009600 ATP binding site [chemical binding]; other site 43989009601 substrate binding site [chemical binding]; other site 43989009602 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 43989009603 substrate binding site [chemical binding]; other site 43989009604 activation loop (A-loop); other site 43989009605 activation loop (A-loop); other site 43989009606 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 43989009607 NAD(P) binding pocket [chemical binding]; other site 43989009608 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 43989009609 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 43989009610 tartrate dehydrogenase; Region: TTC; TIGR02089 43989009611 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 43989009612 putative active site [active] 43989009613 dihydroorotase; Provisional; Region: PRK07575 43989009614 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 43989009615 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 43989009616 active site 43989009617 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 43989009618 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 43989009619 Catalytic site [active] 43989009620 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 43989009621 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 43989009622 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 43989009623 Ligand binding site; other site 43989009624 Putative Catalytic site; other site 43989009625 DXD motif; other site 43989009626 Ycf46; Provisional; Region: ycf46; CHL00195 43989009627 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 43989009628 Walker A motif; other site 43989009629 ATP binding site [chemical binding]; other site 43989009630 Walker B motif; other site 43989009631 arginine finger; other site 43989009632 Protein of unknown function (DUF1257); Region: DUF1257; pfam06868 43989009633 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 43989009634 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 43989009635 active site 43989009636 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 43989009637 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 43989009638 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 43989009639 putative catalytic residue [active] 43989009640 TPR repeat; Region: TPR_11; pfam13414 43989009641 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989009642 binding surface 43989009643 TPR motif; other site 43989009644 TPR repeat; Region: TPR_11; pfam13414 43989009645 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989009646 binding surface 43989009647 TPR motif; other site 43989009648 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989009649 binding surface 43989009650 Tetratricopeptide repeat; Region: TPR_16; pfam13432 43989009651 TPR motif; other site 43989009652 photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044 43989009653 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 43989009654 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 43989009655 Walker A/P-loop; other site 43989009656 ATP binding site [chemical binding]; other site 43989009657 Q-loop/lid; other site 43989009658 ABC transporter signature motif; other site 43989009659 Walker B; other site 43989009660 D-loop; other site 43989009661 H-loop/switch region; other site 43989009662 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 43989009663 Walker A/P-loop; other site 43989009664 ATP binding site [chemical binding]; other site 43989009665 Q-loop/lid; other site 43989009666 ABC transporter signature motif; other site 43989009667 Walker B; other site 43989009668 D-loop; other site 43989009669 H-loop/switch region; other site 43989009670 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 43989009671 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 43989009672 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 43989009673 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 43989009674 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 43989009675 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 43989009676 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 43989009677 TrkA-N domain; Region: TrkA_N; pfam02254 43989009678 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 43989009679 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 43989009680 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 43989009681 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 43989009682 Walker A/P-loop; other site 43989009683 ATP binding site [chemical binding]; other site 43989009684 Q-loop/lid; other site 43989009685 ABC transporter signature motif; other site 43989009686 Walker B; other site 43989009687 D-loop; other site 43989009688 H-loop/switch region; other site 43989009689 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 43989009690 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 43989009691 mannosyl-3-phosphoglycerate synthase; Provisional; Region: PRK14503; cl12225 43989009692 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 43989009693 Caspase domain; Region: Peptidase_C14; pfam00656 43989009694 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 43989009695 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 43989009696 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 43989009697 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 43989009698 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 43989009699 dimer interface [polypeptide binding]; other site 43989009700 conserved gate region; other site 43989009701 putative PBP binding loops; other site 43989009702 ABC-ATPase subunit interface; other site 43989009703 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 43989009704 Protein of unknown function (DUF1257); Region: DUF1257; pfam06868 43989009705 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 43989009706 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 43989009707 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 43989009708 active site 43989009709 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 43989009710 Protein of unknown function (DUF3086); Region: DUF3086; pfam11285 43989009711 Protein of unknown function (DUF3119); Region: DUF3119; pfam11317 43989009712 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 43989009713 putative ADP-binding pocket [chemical binding]; other site 43989009714 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 43989009715 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 43989009716 Cation efflux family; Region: Cation_efflux; pfam01545 43989009717 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 43989009718 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 43989009719 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 43989009720 active site 43989009721 homodimer interface [polypeptide binding]; other site 43989009722 Domain of unknown function DUF29; Region: DUF29; pfam01724 43989009723 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 43989009724 active site 43989009725 catalytic residues [active] 43989009726 metal binding site [ion binding]; metal-binding site 43989009727 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 43989009728 DnaA N-terminal domain; Region: DnaA_N; pfam11638 43989009729 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 43989009730 Walker A motif; other site 43989009731 ATP binding site [chemical binding]; other site 43989009732 Walker B motif; other site 43989009733 arginine finger; other site 43989009734 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 43989009735 DnaA box-binding interface [nucleotide binding]; other site 43989009736 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 43989009737 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 43989009738 RNase_H superfamily; Region: RNase_H_2; pfam13482 43989009739 Tic22-like family; Region: Tic22; pfam04278 43989009740 Tic22-like family; Region: Tic22; cl04468 43989009741 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 43989009742 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989009743 S-adenosylmethionine binding site [chemical binding]; other site 43989009744 PIN domain; Region: PIN_3; cl17397 43989009745 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 43989009746 Mechanosensitive ion channel; Region: MS_channel; pfam00924 43989009747 cobalt transport protein CbiM; Validated; Region: PRK06265 43989009748 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 43989009749 PDGLE domain; Region: PDGLE; pfam13190 43989009750 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 43989009751 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 43989009752 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 43989009753 trimer interface [polypeptide binding]; other site 43989009754 dimer interface [polypeptide binding]; other site 43989009755 putative active site [active] 43989009756 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 43989009757 GSH binding site [chemical binding]; other site 43989009758 catalytic residues [active] 43989009759 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 43989009760 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 43989009761 Coenzyme A binding pocket [chemical binding]; other site 43989009762 bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477 43989009763 Pantoate-beta-alanine ligase; Region: PanC; cd00560 43989009764 active site 43989009765 ATP-binding site [chemical binding]; other site 43989009766 pantoate-binding site; other site 43989009767 HXXH motif; other site 43989009768 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 43989009769 CMP-binding site; other site 43989009770 The sites determining sugar specificity; other site 43989009771 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 43989009772 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 43989009773 Tocopherol cyclase; Region: Tocopherol_cycl; pfam14249 43989009774 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 43989009775 Saccharopine Dehydrogenase like proteins; Region: SDH_like; cd05199 43989009776 active site 43989009777 ligand binding site [chemical binding]; other site 43989009778 NAD(P) binding site [chemical binding]; other site 43989009779 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 43989009780 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 43989009781 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 43989009782 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 43989009783 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 43989009784 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 43989009785 Coenzyme A binding pocket [chemical binding]; other site 43989009786 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 43989009787 Peptidase family M23; Region: Peptidase_M23; pfam01551 43989009788 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 43989009789 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 43989009790 NADH(P)-binding; Region: NAD_binding_10; pfam13460 43989009791 NAD(P) binding site [chemical binding]; other site 43989009792 putative active site [active] 43989009793 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 43989009794 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 43989009795 active site 43989009796 catalytic tetrad [active] 43989009797 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 43989009798 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 43989009799 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 43989009800 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 43989009801 Walker A/P-loop; other site 43989009802 ATP binding site [chemical binding]; other site 43989009803 Q-loop/lid; other site 43989009804 ABC transporter signature motif; other site 43989009805 Walker B; other site 43989009806 D-loop; other site 43989009807 H-loop/switch region; other site 43989009808 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 43989009809 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 43989009810 putative active site [active] 43989009811 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 43989009812 putative active site [active] 43989009813 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 43989009814 active site 43989009815 SAM binding site [chemical binding]; other site 43989009816 homodimer interface [polypeptide binding]; other site 43989009817 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989009818 putative active site [active] 43989009819 PRC-barrel domain; Region: PRC; pfam05239 43989009820 PRC-barrel domain; Region: PRC; pfam05239 43989009821 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 43989009822 Ligand Binding Site [chemical binding]; other site 43989009823 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 43989009824 MoaE interaction surface [polypeptide binding]; other site 43989009825 MoeB interaction surface [polypeptide binding]; other site 43989009826 thiocarboxylated glycine; other site 43989009827 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 43989009828 FAD binding domain; Region: FAD_binding_4; pfam01565 43989009829 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 43989009830 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 43989009831 Cysteine-rich domain; Region: CCG; pfam02754 43989009832 Cysteine-rich domain; Region: CCG; pfam02754 43989009833 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 43989009834 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 43989009835 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 43989009836 ATP binding site [chemical binding]; other site 43989009837 putative Mg++ binding site [ion binding]; other site 43989009838 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 43989009839 nucleotide binding region [chemical binding]; other site 43989009840 ATP-binding site [chemical binding]; other site 43989009841 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 43989009842 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 43989009843 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 43989009844 active site 43989009845 Zn binding site [ion binding]; other site 43989009846 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 43989009847 GAF domain; Region: GAF; pfam01590 43989009848 Phytochrome region; Region: PHY; pfam00360 43989009849 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989009850 dimer interface [polypeptide binding]; other site 43989009851 phosphorylation site [posttranslational modification] 43989009852 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989009853 ATP binding site [chemical binding]; other site 43989009854 Mg2+ binding site [ion binding]; other site 43989009855 G-X-G motif; other site 43989009856 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 43989009857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989009858 active site 43989009859 phosphorylation site [posttranslational modification] 43989009860 intermolecular recognition site; other site 43989009861 dimerization interface [polypeptide binding]; other site 43989009862 Response regulator receiver domain; Region: Response_reg; pfam00072 43989009863 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989009864 active site 43989009865 phosphorylation site [posttranslational modification] 43989009866 intermolecular recognition site; other site 43989009867 dimerization interface [polypeptide binding]; other site 43989009868 PAS domain S-box; Region: sensory_box; TIGR00229 43989009869 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989009870 putative active site [active] 43989009871 heme pocket [chemical binding]; other site 43989009872 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 43989009873 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 43989009874 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 43989009875 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 43989009876 metal binding site [ion binding]; metal-binding site 43989009877 active site 43989009878 I-site; other site 43989009879 quinolinate synthetase; Provisional; Region: PRK09375 43989009880 hypothetical protein; Provisional; Region: PRK07394 43989009881 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 43989009882 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 43989009883 Transposase; Region: DDE_Tnp_ISL3; pfam01610 43989009884 alanine racemase; Reviewed; Region: alr; PRK00053 43989009885 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 43989009886 active site 43989009887 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 43989009888 dimer interface [polypeptide binding]; other site 43989009889 substrate binding site [chemical binding]; other site 43989009890 catalytic residues [active] 43989009891 Uncharacterized conserved protein [Function unknown]; Region: COG1434 43989009892 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 43989009893 putative active site [active] 43989009894 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 43989009895 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 43989009896 Response regulator receiver domain; Region: Response_reg; pfam00072 43989009897 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989009898 active site 43989009899 phosphorylation site [posttranslational modification] 43989009900 intermolecular recognition site; other site 43989009901 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 43989009902 dimerization interface [polypeptide binding]; other site 43989009903 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989009904 dimer interface [polypeptide binding]; other site 43989009905 phosphorylation site [posttranslational modification] 43989009906 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989009907 ATP binding site [chemical binding]; other site 43989009908 Mg2+ binding site [ion binding]; other site 43989009909 G-X-G motif; other site 43989009910 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989009911 PAS fold; Region: PAS_3; pfam08447 43989009912 putative active site [active] 43989009913 heme pocket [chemical binding]; other site 43989009914 PAS fold; Region: PAS_4; pfam08448 43989009915 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989009916 putative active site [active] 43989009917 heme pocket [chemical binding]; other site 43989009918 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 43989009919 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 43989009920 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 43989009921 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989009922 putative active site [active] 43989009923 heme pocket [chemical binding]; other site 43989009924 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989009925 dimer interface [polypeptide binding]; other site 43989009926 phosphorylation site [posttranslational modification] 43989009927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989009928 ATP binding site [chemical binding]; other site 43989009929 Mg2+ binding site [ion binding]; other site 43989009930 G-X-G motif; other site 43989009931 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 43989009932 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989009933 active site 43989009934 phosphorylation site [posttranslational modification] 43989009935 intermolecular recognition site; other site 43989009936 dimerization interface [polypeptide binding]; other site 43989009937 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 43989009938 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 43989009939 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 43989009940 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 43989009941 active site 43989009942 Zn binding site [ion binding]; other site 43989009943 Protein of unknown function (DUF3124); Region: DUF3124; pfam11322 43989009944 aspartate aminotransferase; Provisional; Region: PRK05942 43989009945 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 43989009946 pyridoxal 5'-phosphate binding site [chemical binding]; other site 43989009947 homodimer interface [polypeptide binding]; other site 43989009948 catalytic residue [active] 43989009949 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 43989009950 Cytochrome P450; Region: p450; cl12078 43989009951 MEKHLA domain; Region: MEKHLA; pfam08670 43989009952 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 43989009953 Transcriptional regulator [Transcription]; Region: LysR; COG0583 43989009954 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 43989009955 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 43989009956 putative dimerization interface [polypeptide binding]; other site 43989009957 Rhomboid family; Region: Rhomboid; pfam01694 43989009958 Protein of unknown function (DUF2854); Region: DUF2854; pfam11016 43989009959 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 43989009960 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 43989009961 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 43989009962 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 43989009963 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 43989009964 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 43989009965 CoA-binding site [chemical binding]; other site 43989009966 ATP-binding [chemical binding]; other site 43989009967 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 43989009968 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 43989009969 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 43989009970 ribonuclease E; Reviewed; Region: rne; PRK10811 43989009971 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 43989009972 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 43989009973 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 43989009974 CHASE2 domain; Region: CHASE2; pfam05226 43989009975 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 43989009976 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 43989009977 metal binding site [ion binding]; metal-binding site 43989009978 active site 43989009979 I-site; other site 43989009980 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 43989009981 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 43989009982 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 43989009983 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 43989009984 Dimer interface [polypeptide binding]; other site 43989009985 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 43989009986 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 43989009987 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 43989009988 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 43989009989 homodimer interface [polypeptide binding]; other site 43989009990 substrate-cofactor binding pocket; other site 43989009991 Aminotransferase class IV; Region: Aminotran_4; pfam01063 43989009992 pyridoxal 5'-phosphate binding site [chemical binding]; other site 43989009993 catalytic residue [active] 43989009994 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 43989009995 Transcriptional regulator [Transcription]; Region: LysR; COG0583 43989009996 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 43989009997 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 43989009998 putative effector binding pocket; other site 43989009999 dimerization interface [polypeptide binding]; other site 43989010000 phytoene desaturase; Region: phytoene_desat; TIGR02731 43989010001 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 43989010002 Elongation factor TS; Region: EF_TS; pfam00889 43989010003 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 43989010004 active site lid residues [active] 43989010005 substrate binding pocket [chemical binding]; other site 43989010006 catalytic residues [active] 43989010007 substrate-Mg2+ binding site; other site 43989010008 aspartate-rich region 1; other site 43989010009 aspartate-rich region 2; other site 43989010010 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4704 43989010011 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 43989010012 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 43989010013 metal binding site [ion binding]; metal-binding site 43989010014 dimer interface [polypeptide binding]; other site 43989010015 acyl-CoA synthetase; Validated; Region: PRK05850 43989010016 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 43989010017 acyl-activating enzyme (AAE) consensus motif; other site 43989010018 active site 43989010019 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 43989010020 Fatty acid desaturase; Region: FA_desaturase; pfam00487 43989010021 Di-iron ligands [ion binding]; other site 43989010022 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 43989010023 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 43989010024 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 43989010025 active site 43989010026 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 43989010027 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 43989010028 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 43989010029 Thioesterase domain; Region: Thioesterase; pfam00975 43989010030 Methyltransferase domain; Region: Methyltransf_31; pfam13847 43989010031 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989010032 S-adenosylmethionine binding site [chemical binding]; other site 43989010033 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 43989010034 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 43989010035 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 43989010036 putative active site [active] 43989010037 PhoH-like protein; Region: PhoH; pfam02562 43989010038 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 43989010039 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 43989010040 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 43989010041 dimer interface [polypeptide binding]; other site 43989010042 PYR/PP interface [polypeptide binding]; other site 43989010043 TPP binding site [chemical binding]; other site 43989010044 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 43989010045 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 43989010046 TPP-binding site [chemical binding]; other site 43989010047 dimer interface [polypeptide binding]; other site 43989010048 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 43989010049 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 43989010050 active site 43989010051 Zn binding site [ion binding]; other site 43989010052 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 43989010053 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 43989010054 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 43989010055 Transposase [DNA replication, recombination, and repair]; Region: COG5433 43989010056 Transposase [DNA replication, recombination, and repair]; Region: COG5433 43989010057 Transposase; Region: DDE_Tnp_ISL3; pfam01610 43989010058 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 43989010059 HEAT repeats; Region: HEAT_2; pfam13646 43989010060 HEAT repeats; Region: HEAT_2; pfam13646 43989010061 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 43989010062 HEAT repeats; Region: HEAT_2; pfam13646 43989010063 CpeS-like protein; Region: CpeS; pfam09367 43989010064 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 43989010065 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 43989010066 putative NAD(P) binding site [chemical binding]; other site 43989010067 active site 43989010068 UDP-glucose 4-epimerase C-term subunit; Region: Epimerase_Csub; pfam13950 43989010069 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 43989010070 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 43989010071 DNA binding residues [nucleotide binding] 43989010072 putative dimer interface [polypeptide binding]; other site 43989010073 DNA methylase; Region: N6_N4_Mtase; cl17433 43989010074 AAA-like domain; Region: AAA_10; pfam12846 43989010075 DDE superfamily endonuclease; Region: DDE_4; pfam13359 43989010076 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 43989010077 Protein of unknown function, DUF488; Region: DUF488; pfam04343 43989010078 Bacterial TniB protein; Region: TniB; pfam05621 43989010079 AAA domain; Region: AAA_22; pfam13401 43989010080 Helix-turn-helix domain; Region: HTH_28; pfam13518 43989010081 Winged helix-turn helix; Region: HTH_29; pfam13551 43989010082 Homeodomain-like domain; Region: HTH_32; pfam13565 43989010083 Integrase core domain; Region: rve; pfam00665 43989010084 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 43989010085 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 43989010086 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 43989010087 heme-binding site [chemical binding]; other site 43989010088 Methyltransferase domain; Region: Methyltransf_31; pfam13847 43989010089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989010090 S-adenosylmethionine binding site [chemical binding]; other site 43989010091 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 43989010092 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 43989010093 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 43989010094 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 43989010095 ligand binding site [chemical binding]; other site 43989010096 flexible hinge region; other site 43989010097 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 43989010098 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 43989010099 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 43989010100 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 43989010101 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 43989010102 Walker A/P-loop; other site 43989010103 ATP binding site [chemical binding]; other site 43989010104 Q-loop/lid; other site 43989010105 ABC transporter signature motif; other site 43989010106 Walker B; other site 43989010107 D-loop; other site 43989010108 H-loop/switch region; other site 43989010109 TOBE domain; Region: TOBE_2; pfam08402 43989010110 DDE superfamily endonuclease; Region: DDE_3; pfam13358 43989010111 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 43989010112 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 43989010113 Homeodomain-like domain; Region: HTH_32; pfam13565 43989010114 Homeodomain-like domain; Region: HTH_23; pfam13384 43989010115 DDE superfamily endonuclease; Region: DDE_3; pfam13358 43989010116 Domain of unknown function (DUF3598); Region: DUF3598; pfam12204 43989010117 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 43989010118 adenylosuccinate lyase; Provisional; Region: PRK07380 43989010119 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 43989010120 tetramer interface [polypeptide binding]; other site 43989010121 active site 43989010122 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 43989010123 This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511 43989010124 Fatty acid desaturase; Region: FA_desaturase; pfam00487 43989010125 putative di-iron ligands [ion binding]; other site 43989010126 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 43989010127 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 43989010128 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 43989010129 Hexamer interface [polypeptide binding]; other site 43989010130 Hexagonal pore residue; other site 43989010131 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 43989010132 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 43989010133 Hexamer interface [polypeptide binding]; other site 43989010134 Hexagonal pore residue; other site 43989010135 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 43989010136 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 43989010137 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 43989010138 hypothetical protein; Provisional; Region: PRK02509 43989010139 Uncharacterized conserved protein [Function unknown]; Region: COG1615 43989010140 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 43989010141 Cytochrome P450; Region: p450; pfam00067 43989010142 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 43989010143 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 43989010144 Walker A/P-loop; other site 43989010145 ATP binding site [chemical binding]; other site 43989010146 Q-loop/lid; other site 43989010147 ABC transporter signature motif; other site 43989010148 Walker B; other site 43989010149 D-loop; other site 43989010150 H-loop/switch region; other site 43989010151 TOBE-like domain; Region: TOBE_3; pfam12857 43989010152 sulfate transport protein; Provisional; Region: cysT; CHL00187 43989010153 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 43989010154 dimer interface [polypeptide binding]; other site 43989010155 conserved gate region; other site 43989010156 putative PBP binding loops; other site 43989010157 ABC-ATPase subunit interface; other site 43989010158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 43989010159 dimer interface [polypeptide binding]; other site 43989010160 conserved gate region; other site 43989010161 putative PBP binding loops; other site 43989010162 ABC-ATPase subunit interface; other site 43989010163 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 43989010164 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 43989010165 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 43989010166 Domain of unknown function (DUF202); Region: DUF202; pfam02656 43989010167 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 43989010168 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 43989010169 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 43989010170 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 43989010171 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 43989010172 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 43989010173 Predicted membrane protein [Function unknown]; Region: COG3431 43989010174 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 43989010175 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 43989010176 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 43989010177 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 43989010178 flavoprotein, HI0933 family; Region: TIGR00275 43989010179 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 43989010180 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 43989010181 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 43989010182 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 43989010183 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 43989010184 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 43989010185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 43989010186 putative substrate translocation pore; other site 43989010187 phosphate:H+ symporter; Region: 2A0109; TIGR00887 43989010188 Domain of unknown function (DUF202); Region: DUF202; pfam02656 43989010189 Sodium Bile acid symporter family; Region: SBF; cl17470 43989010190 Domain of unknown function (DUF202); Region: DUF202; pfam02656 43989010191 Domain of unknown function (DUF202); Region: DUF202; cl09954 43989010192 Domain of unknown function (DUF202); Region: DUF202; cl09954 43989010193 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 43989010194 Sulfatase; Region: Sulfatase; pfam00884 43989010195 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 43989010196 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 43989010197 DDE superfamily endonuclease; Region: DDE_3; pfam13358 43989010198 Homeodomain-like domain; Region: HTH_23; pfam13384 43989010199 DDE superfamily endonuclease; Region: DDE_3; pfam13358 43989010200 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 43989010201 Sulfatase; Region: Sulfatase; pfam00884 43989010202 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 43989010203 DDE superfamily endonuclease; Region: DDE_3; pfam13358 43989010204 Homeodomain-like domain; Region: HTH_23; pfam13384 43989010205 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 43989010206 DDE superfamily endonuclease; Region: DDE_3; pfam13358 43989010207 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 43989010208 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 43989010209 Homeodomain-like domain; Region: HTH_32; pfam13565 43989010210 bifunctional enterobactin receptor/adhesin protein; Provisional; Region: PRK13486 43989010211 MarC family integral membrane protein; Region: MarC; cl00919 43989010212 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 43989010213 Sulfatase; Region: Sulfatase; pfam00884 43989010214 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 43989010215 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 43989010216 NADH(P)-binding; Region: NAD_binding_10; pfam13460 43989010217 NAD(P) binding site [chemical binding]; other site 43989010218 putative active site [active] 43989010219 MgtC family; Region: MgtC; pfam02308 43989010220 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 43989010221 Mechanosensitive ion channel; Region: MS_channel; pfam00924 43989010222 serine O-acetyltransferase; Region: cysE; TIGR01172 43989010223 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 43989010224 trimer interface [polypeptide binding]; other site 43989010225 active site 43989010226 substrate binding site [chemical binding]; other site 43989010227 CoA binding site [chemical binding]; other site 43989010228 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 43989010229 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 43989010230 Walker A/P-loop; other site 43989010231 ATP binding site [chemical binding]; other site 43989010232 Q-loop/lid; other site 43989010233 ABC transporter signature motif; other site 43989010234 Walker B; other site 43989010235 D-loop; other site 43989010236 H-loop/switch region; other site 43989010237 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 43989010238 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 43989010239 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 43989010240 putative ligand binding site [chemical binding]; other site 43989010241 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 43989010242 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 43989010243 Catalytic site [active] 43989010244 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 43989010245 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 43989010246 homodimer interface [polypeptide binding]; other site 43989010247 metal binding site [ion binding]; metal-binding site 43989010248 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 43989010249 homodimer interface [polypeptide binding]; other site 43989010250 active site 43989010251 putative chemical substrate binding site [chemical binding]; other site 43989010252 metal binding site [ion binding]; metal-binding site 43989010253 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 43989010254 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 43989010255 Ligand Binding Site [chemical binding]; other site 43989010256 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 43989010257 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 43989010258 active site 43989010259 metal binding site [ion binding]; metal-binding site 43989010260 potassium-transporting ATPase subunit C; Provisional; Region: PRK14003 43989010261 F subunit of K+-transporting ATPase (Potass_KdpF); Region: Potass_KdpF; pfam09604 43989010262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989010263 active site 43989010264 phosphorylation site [posttranslational modification] 43989010265 intermolecular recognition site; other site 43989010266 dimerization interface [polypeptide binding]; other site 43989010267 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989010268 TPR motif; other site 43989010269 Tetratricopeptide repeat; Region: TPR_16; pfam13432 43989010270 binding surface 43989010271 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 43989010272 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 43989010273 Soluble P-type ATPase [General function prediction only]; Region: COG4087 43989010274 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 43989010275 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989010276 putative active site [active] 43989010277 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 43989010278 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989010279 dimer interface [polypeptide binding]; other site 43989010280 phosphorylation site [posttranslational modification] 43989010281 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989010282 ATP binding site [chemical binding]; other site 43989010283 Mg2+ binding site [ion binding]; other site 43989010284 G-X-G motif; other site 43989010285 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 43989010286 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989010287 active site 43989010288 phosphorylation site [posttranslational modification] 43989010289 intermolecular recognition site; other site 43989010290 dimerization interface [polypeptide binding]; other site 43989010291 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 43989010292 DNA binding residues [nucleotide binding] 43989010293 dimerization interface [polypeptide binding]; other site 43989010294 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 43989010295 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 43989010296 putative active site [active] 43989010297 catalytic triad [active] 43989010298 putative dimer interface [polypeptide binding]; other site 43989010299 Sporulation and spore germination; Region: Germane; pfam10646 43989010300 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 43989010301 Protein of unknown function (DUF3067); Region: DUF3067; pfam11267 43989010302 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 43989010303 Catalytic domain of Protein Kinases; Region: PKc; cd00180 43989010304 active site 43989010305 ATP binding site [chemical binding]; other site 43989010306 substrate binding site [chemical binding]; other site 43989010307 activation loop (A-loop); other site 43989010308 Uncharacterized conserved protein [Function unknown]; Region: COG1262 43989010309 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 43989010310 PemK-like protein; Region: PemK; pfam02452 43989010311 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 43989010312 putative ADP-ribose binding site [chemical binding]; other site 43989010313 putative active site [active] 43989010314 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 43989010315 active site 43989010316 Protein of unknown function (DUF2930); Region: DUF2930; pfam11152 43989010317 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 43989010318 putative active site pocket [active] 43989010319 dimerization interface [polypeptide binding]; other site 43989010320 putative catalytic residue [active] 43989010321 Protein of unknown function (DUF497); Region: DUF497; pfam04365 43989010322 Protein of unknown function (DUF497); Region: DUF497; cl01108 43989010323 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 43989010324 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 43989010325 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 43989010326 NAD(P) binding site [chemical binding]; other site 43989010327 active site 43989010328 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 43989010329 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 43989010330 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 43989010331 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 43989010332 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 43989010333 motif II; other site 43989010334 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 43989010335 Domain of unknown function DUF29; Region: DUF29; pfam01724 43989010336 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 43989010337 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 43989010338 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 43989010339 homotrimer interaction site [polypeptide binding]; other site 43989010340 putative active site [active] 43989010341 NACHT domain; Region: NACHT; pfam05729 43989010342 FOG: WD40 repeat [General function prediction only]; Region: COG2319 43989010343 WD40 repeats; Region: WD40; smart00320 43989010344 FOG: WD40 repeat [General function prediction only]; Region: COG2319 43989010345 WD domain, G-beta repeat; Region: WD40; pfam00400 43989010346 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 43989010347 structural tetrad; other site 43989010348 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 43989010349 structural tetrad; other site 43989010350 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 43989010351 Predicted chitinase [General function prediction only]; Region: COG3179 43989010352 catalytic residue [active] 43989010353 Peptidase M15; Region: Peptidase_M15_3; cl01194 43989010354 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 43989010355 FOG: WD40 repeat [General function prediction only]; Region: COG2319 43989010356 structural tetrad; other site 43989010357 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 43989010358 structural tetrad; other site 43989010359 FOG: WD40 repeat [General function prediction only]; Region: COG2319 43989010360 WD40 repeats; Region: WD40; smart00320 43989010361 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 43989010362 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 43989010363 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 43989010364 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 43989010365 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 43989010366 putative catalytic site [active] 43989010367 putative metal binding site [ion binding]; other site 43989010368 putative phosphate binding site [ion binding]; other site 43989010369 Endonuclease I; Region: Endonuclease_1; cl01003 43989010370 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 43989010371 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 43989010372 short chain dehydrogenase; Provisional; Region: PRK07454 43989010373 classical (c) SDRs; Region: SDR_c; cd05233 43989010374 NAD(P) binding site [chemical binding]; other site 43989010375 active site 43989010376 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 43989010377 homodecamer interface [polypeptide binding]; other site 43989010378 GTP cyclohydrolase I; Provisional; Region: PLN03044 43989010379 active site 43989010380 putative catalytic site residues [active] 43989010381 zinc binding site [ion binding]; other site 43989010382 GTP-CH-I/GFRP interaction surface; other site 43989010383 CHASE domain; Region: CHASE; pfam03924 43989010384 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989010385 dimer interface [polypeptide binding]; other site 43989010386 phosphorylation site [posttranslational modification] 43989010387 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989010388 ATP binding site [chemical binding]; other site 43989010389 Mg2+ binding site [ion binding]; other site 43989010390 G-X-G motif; other site 43989010391 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 43989010392 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989010393 active site 43989010394 phosphorylation site [posttranslational modification] 43989010395 intermolecular recognition site; other site 43989010396 dimerization interface [polypeptide binding]; other site 43989010397 Response regulator receiver domain; Region: Response_reg; pfam00072 43989010398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989010399 active site 43989010400 phosphorylation site [posttranslational modification] 43989010401 intermolecular recognition site; other site 43989010402 dimerization interface [polypeptide binding]; other site 43989010403 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989010404 PAS domain; Region: PAS_9; pfam13426 43989010405 putative active site [active] 43989010406 heme pocket [chemical binding]; other site 43989010407 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 43989010408 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 43989010409 metal binding site [ion binding]; metal-binding site 43989010410 active site 43989010411 I-site; other site 43989010412 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 43989010413 active site 43989010414 Ca binding site [ion binding]; other site 43989010415 catalytic site [active] 43989010416 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 43989010417 non-specific DNA binding site [nucleotide binding]; other site 43989010418 salt bridge; other site 43989010419 sequence-specific DNA binding site [nucleotide binding]; other site 43989010420 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 43989010421 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 43989010422 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 43989010423 active site 43989010424 dimer interface [polypeptide binding]; other site 43989010425 motif 1; other site 43989010426 motif 2; other site 43989010427 motif 3; other site 43989010428 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 43989010429 anticodon binding site; other site 43989010430 Uncharacterized conserved protein [Function unknown]; Region: COG3339 43989010431 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 43989010432 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 43989010433 dimer interface [polypeptide binding]; other site 43989010434 active site 43989010435 glycine-pyridoxal phosphate binding site [chemical binding]; other site 43989010436 folate binding site [chemical binding]; other site 43989010437 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 43989010438 nucleoside/Zn binding site; other site 43989010439 dimer interface [polypeptide binding]; other site 43989010440 catalytic motif [active] 43989010441 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 43989010442 RNA/DNA hybrid binding site [nucleotide binding]; other site 43989010443 active site 43989010444 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 43989010445 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 43989010446 dimerization interface [polypeptide binding]; other site 43989010447 putative ATP binding site [chemical binding]; other site 43989010448 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 43989010449 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 43989010450 Ligand binding site; other site 43989010451 Putative Catalytic site; other site 43989010452 DXD motif; other site 43989010453 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 43989010454 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 43989010455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989010456 active site 43989010457 phosphorylation site [posttranslational modification] 43989010458 intermolecular recognition site; other site 43989010459 dimerization interface [polypeptide binding]; other site 43989010460 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 43989010461 DNA binding site [nucleotide binding] 43989010462 HupF/HypC family; Region: HupF_HypC; pfam01455 43989010463 photosystem I reaction center subunit VIII; Reviewed; Region: psaI; PRK11877 43989010464 photosystem I reaction center protein subunit XI; Provisional; Region: PRK00704 43989010465 Photosystem I reaction centre subunit XI; Region: PsaL; pfam02605 43989010466 Domain of unknown function (DUF1815); Region: DUF1815; pfam08844 43989010467 Protein of function (DUF2518); Region: DUF2518; pfam10726 43989010468 precorrin-8X methylmutase; Provisional; Region: PRK05954 43989010469 Precorrin-8X methylmutase; Region: CbiC; pfam02570 43989010470 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 43989010471 active site 43989010472 putative homodimer interface [polypeptide binding]; other site 43989010473 SAM binding site [chemical binding]; other site 43989010474 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 43989010475 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989010476 S-adenosylmethionine binding site [chemical binding]; other site 43989010477 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 43989010478 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 43989010479 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 43989010480 ABC transporter; Region: ABC_tran_2; pfam12848 43989010481 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 43989010482 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 43989010483 AAA domain; Region: AAA_18; pfam13238 43989010484 ligand-binding site [chemical binding]; other site 43989010485 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 43989010486 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 43989010487 putative active site [active] 43989010488 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 43989010489 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 43989010490 tRNA; other site 43989010491 putative tRNA binding site [nucleotide binding]; other site 43989010492 putative NADP binding site [chemical binding]; other site 43989010493 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 43989010494 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 43989010495 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 43989010496 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 43989010497 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 43989010498 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989010499 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989010500 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 43989010501 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989010502 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989010503 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989010504 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989010505 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989010506 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989010507 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 43989010508 dimerization interface [polypeptide binding]; other site 43989010509 putative DNA binding site [nucleotide binding]; other site 43989010510 putative Zn2+ binding site [ion binding]; other site 43989010511 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 43989010512 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 43989010513 phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972 43989010514 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 43989010515 Walker A/P-loop; other site 43989010516 ATP binding site [chemical binding]; other site 43989010517 Q-loop/lid; other site 43989010518 ABC transporter signature motif; other site 43989010519 Walker B; other site 43989010520 D-loop; other site 43989010521 H-loop/switch region; other site 43989010522 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 43989010523 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 43989010524 active site 43989010525 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 43989010526 Part of AAA domain; Region: AAA_19; pfam13245 43989010527 Family description; Region: UvrD_C_2; pfam13538 43989010528 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 43989010529 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 43989010530 catalytic residues [active] 43989010531 Fatty acid desaturase; Region: FA_desaturase; pfam00487 43989010532 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 43989010533 Di-iron ligands [ion binding]; other site 43989010534 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 43989010535 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 43989010536 dimer interface [polypeptide binding]; other site 43989010537 motif 1; other site 43989010538 active site 43989010539 motif 2; other site 43989010540 motif 3; other site 43989010541 carboxyl-terminal processing protease; Provisional; Region: PLN00049 43989010542 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 43989010543 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 43989010544 protein binding site [polypeptide binding]; other site 43989010545 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 43989010546 Catalytic dyad [active] 43989010547 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 43989010548 putative catalytic site [active] 43989010549 putative phosphate binding site [ion binding]; other site 43989010550 active site 43989010551 metal binding site A [ion binding]; metal-binding site 43989010552 DNA binding site [nucleotide binding] 43989010553 putative AP binding site [nucleotide binding]; other site 43989010554 putative metal binding site B [ion binding]; other site 43989010555 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 43989010556 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 43989010557 cofactor binding site; other site 43989010558 DNA binding site [nucleotide binding] 43989010559 substrate interaction site [chemical binding]; other site 43989010560 Predicted membrane protein [Function unknown]; Region: COG1971 43989010561 Domain of unknown function DUF; Region: DUF204; pfam02659 43989010562 Uncharacterized conserved protein [Function unknown]; Region: COG0398 43989010563 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 43989010564 putative glycosyl transferase; Provisional; Region: PRK10307 43989010565 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 43989010566 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 43989010567 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 43989010568 DNA repair protein RadA; Provisional; Region: PRK11823 43989010569 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 43989010570 Walker A motif/ATP binding site; other site 43989010571 ATP binding site [chemical binding]; other site 43989010572 Walker B motif; other site 43989010573 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 43989010574 Ycf27; Reviewed; Region: orf27; CHL00148 43989010575 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989010576 active site 43989010577 phosphorylation site [posttranslational modification] 43989010578 intermolecular recognition site; other site 43989010579 dimerization interface [polypeptide binding]; other site 43989010580 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 43989010581 DNA binding site [nucleotide binding] 43989010582 asparagine synthetase B; Provisional; Region: asnB; PRK09431 43989010583 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 43989010584 active site 43989010585 dimer interface [polypeptide binding]; other site 43989010586 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 43989010587 Ligand Binding Site [chemical binding]; other site 43989010588 Molecular Tunnel; other site 43989010589 molecular chaperone DnaK; Provisional; Region: PRK13411 43989010590 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 43989010591 nucleotide binding site [chemical binding]; other site 43989010592 NEF interaction site [polypeptide binding]; other site 43989010593 SBD interface [polypeptide binding]; other site 43989010594 GrpE; Region: GrpE; pfam01025 43989010595 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 43989010596 dimer interface [polypeptide binding]; other site 43989010597 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 43989010598 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 43989010599 putative binding surface; other site 43989010600 active site 43989010601 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 43989010602 HSP70 interaction site [polypeptide binding]; other site 43989010603 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 43989010604 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989010605 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989010606 2-isopropylmalate synthase; Validated; Region: PRK00915 43989010607 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 43989010608 active site 43989010609 catalytic residues [active] 43989010610 metal binding site [ion binding]; metal-binding site 43989010611 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 43989010612 Phosphotransferase enzyme family; Region: APH; pfam01636 43989010613 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 43989010614 active site 43989010615 substrate binding site [chemical binding]; other site 43989010616 ATP binding site [chemical binding]; other site 43989010617 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 43989010618 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 43989010619 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 43989010620 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 43989010621 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 43989010622 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 43989010623 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 43989010624 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 43989010625 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 43989010626 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 43989010627 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 43989010628 putative translocon binding site; other site 43989010629 protein-rRNA interface [nucleotide binding]; other site 43989010630 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 43989010631 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 43989010632 G-X-X-G motif; other site 43989010633 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 43989010634 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 43989010635 23S rRNA interface [nucleotide binding]; other site 43989010636 5S rRNA interface [nucleotide binding]; other site 43989010637 putative antibiotic binding site [chemical binding]; other site 43989010638 L25 interface [polypeptide binding]; other site 43989010639 L27 interface [polypeptide binding]; other site 43989010640 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 43989010641 putative translocon interaction site; other site 43989010642 23S rRNA interface [nucleotide binding]; other site 43989010643 signal recognition particle (SRP54) interaction site; other site 43989010644 L23 interface [polypeptide binding]; other site 43989010645 trigger factor interaction site; other site 43989010646 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 43989010647 ribosomal protein L14; Region: rpl14; CHL00057 43989010648 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 43989010649 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 43989010650 RNA binding site [nucleotide binding]; other site 43989010651 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 43989010652 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 43989010653 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 43989010654 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 43989010655 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 43989010656 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 43989010657 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 43989010658 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 43989010659 23S rRNA interface [nucleotide binding]; other site 43989010660 5S rRNA interface [nucleotide binding]; other site 43989010661 L27 interface [polypeptide binding]; other site 43989010662 L5 interface [polypeptide binding]; other site 43989010663 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 43989010664 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 43989010665 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 43989010666 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 43989010667 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 43989010668 SecY translocase; Region: SecY; pfam00344 43989010669 adenylate kinase; Provisional; Region: adk; PRK02496 43989010670 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 43989010671 AMP-binding site [chemical binding]; other site 43989010672 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 43989010673 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 43989010674 rRNA binding site [nucleotide binding]; other site 43989010675 predicted 30S ribosome binding site; other site 43989010676 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 43989010677 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 43989010678 30S ribosomal protein S13; Region: bact_S13; TIGR03631 43989010679 30S ribosomal protein S11; Validated; Region: PRK05309 43989010680 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 43989010681 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 43989010682 alphaNTD homodimer interface [polypeptide binding]; other site 43989010683 alphaNTD - beta interaction site [polypeptide binding]; other site 43989010684 alphaNTD - beta' interaction site [polypeptide binding]; other site 43989010685 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 43989010686 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 43989010687 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 43989010688 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 43989010689 dimerization interface 3.5A [polypeptide binding]; other site 43989010690 active site 43989010691 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 43989010692 23S rRNA interface [nucleotide binding]; other site 43989010693 L3 interface [polypeptide binding]; other site 43989010694 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 43989010695 ribosomal protein L31; Validated; Region: rpl31; CHL00136 43989010696 peptide chain release factor 1; Validated; Region: prfA; PRK00591 43989010697 This domain is found in peptide chain release factors; Region: PCRF; smart00937 43989010698 RF-1 domain; Region: RF-1; pfam00472 43989010699 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 43989010700 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 43989010701 dimer interface [polypeptide binding]; other site 43989010702 putative metal binding site [ion binding]; other site 43989010703 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 43989010704 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 43989010705 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 43989010706 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 43989010707 active site 43989010708 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 43989010709 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 43989010710 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 43989010711 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 43989010712 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 43989010713 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 43989010714 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 43989010715 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989010716 putative active site [active] 43989010717 Domain of unknown function DUF29; Region: DUF29; pfam01724 43989010718 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 43989010719 TrkA-N domain; Region: TrkA_N; pfam02254 43989010720 TrkA-C domain; Region: TrkA_C; pfam02080 43989010721 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989010722 putative active site [active] 43989010723 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 43989010724 Catalytic domain of Protein Kinases; Region: PKc; cd00180 43989010725 active site 43989010726 ATP binding site [chemical binding]; other site 43989010727 substrate binding site [chemical binding]; other site 43989010728 activation loop (A-loop); other site 43989010729 Mg chelatase-related protein; Region: TIGR00368 43989010730 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 43989010731 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 43989010732 Walker A motif; other site 43989010733 ATP binding site [chemical binding]; other site 43989010734 Walker B motif; other site 43989010735 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 43989010736 Uncharacterized conserved protein [Function unknown]; Region: COG1479 43989010737 Protein of unknown function DUF262; Region: DUF262; pfam03235 43989010738 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 43989010739 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 43989010740 Protein of unknown function DUF262; Region: DUF262; pfam03235 43989010741 Uncharacterized conserved protein [Function unknown]; Region: COG1479 43989010742 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 43989010743 ribonuclease Z; Region: RNase_Z; TIGR02651 43989010744 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 43989010745 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 43989010746 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 43989010747 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 43989010748 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 43989010749 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 43989010750 Walker A/P-loop; other site 43989010751 ATP binding site [chemical binding]; other site 43989010752 Q-loop/lid; other site 43989010753 ABC transporter signature motif; other site 43989010754 Walker B; other site 43989010755 D-loop; other site 43989010756 H-loop/switch region; other site 43989010757 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 43989010758 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 43989010759 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 43989010760 Ycf39; Provisional; Region: ycf39; CHL00194 43989010761 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 43989010762 NAD(P) binding site [chemical binding]; other site 43989010763 putative active site [active] 43989010764 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649 43989010765 ATP-NAD kinase; Region: NAD_kinase; pfam01513 43989010766 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 43989010767 Amidase; Region: Amidase; pfam01425 43989010768 DNA polymerase III subunit alpha; Reviewed; Region: PRK09532 43989010769 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 43989010770 active site 43989010771 PHP Thumb interface [polypeptide binding]; other site 43989010772 metal binding site [ion binding]; metal-binding site 43989010773 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 43989010774 protein-splicing catalytic site; other site 43989010775 thioester formation/cholesterol transfer; other site 43989010776 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 43989010777 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 43989010778 dimerization interface [polypeptide binding]; other site 43989010779 domain crossover interface; other site 43989010780 redox-dependent activation switch; other site 43989010781 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 43989010782 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 43989010783 Walker A/P-loop; other site 43989010784 ATP binding site [chemical binding]; other site 43989010785 Q-loop/lid; other site 43989010786 ABC transporter signature motif; other site 43989010787 Walker B; other site 43989010788 D-loop; other site 43989010789 H-loop/switch region; other site 43989010790 TOBE domain; Region: TOBE_2; pfam08402 43989010791 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 43989010792 active site 43989010793 oxyanion hole [active] 43989010794 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 43989010795 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 43989010796 catalytic residues [active] 43989010797 flagellar capping protein; Provisional; Region: PRK12765 43989010798 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 43989010799 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 43989010800 elongation factor Tu; Region: tufA; CHL00071 43989010801 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 43989010802 G1 box; other site 43989010803 GEF interaction site [polypeptide binding]; other site 43989010804 GTP/Mg2+ binding site [chemical binding]; other site 43989010805 Switch I region; other site 43989010806 G2 box; other site 43989010807 G3 box; other site 43989010808 Switch II region; other site 43989010809 G4 box; other site 43989010810 G5 box; other site 43989010811 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 43989010812 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 43989010813 Antibiotic Binding Site [chemical binding]; other site 43989010814 elongation factor G; Reviewed; Region: PRK00007 43989010815 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 43989010816 G1 box; other site 43989010817 putative GEF interaction site [polypeptide binding]; other site 43989010818 GTP/Mg2+ binding site [chemical binding]; other site 43989010819 Switch I region; other site 43989010820 G2 box; other site 43989010821 G3 box; other site 43989010822 Switch II region; other site 43989010823 G4 box; other site 43989010824 G5 box; other site 43989010825 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 43989010826 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 43989010827 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 43989010828 30S ribosomal protein S7; Validated; Region: PRK05302 43989010829 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 43989010830 S17 interaction site [polypeptide binding]; other site 43989010831 S8 interaction site; other site 43989010832 16S rRNA interaction site [nucleotide binding]; other site 43989010833 streptomycin interaction site [chemical binding]; other site 43989010834 23S rRNA interaction site [nucleotide binding]; other site 43989010835 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 43989010836 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 43989010837 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 43989010838 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 43989010839 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 43989010840 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 43989010841 B12 binding site [chemical binding]; other site 43989010842 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 43989010843 FeS/SAM binding site; other site 43989010844 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 43989010845 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 43989010846 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 43989010847 Catalytic domain of Protein Kinases; Region: PKc; cd00180 43989010848 active site 43989010849 ATP binding site [chemical binding]; other site 43989010850 substrate binding site [chemical binding]; other site 43989010851 activation loop (A-loop); other site 43989010852 AAA ATPase domain; Region: AAA_16; pfam13191 43989010853 Predicted ATPase [General function prediction only]; Region: COG3899 43989010854 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 43989010855 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 43989010856 PAS fold; Region: PAS_4; pfam08448 43989010857 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989010858 putative active site [active] 43989010859 heme pocket [chemical binding]; other site 43989010860 Amidohydrolase; Region: Amidohydro_2; pfam04909 43989010861 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 43989010862 YcaO-like family; Region: YcaO; pfam02624 43989010863 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 43989010864 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 43989010865 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 43989010866 Predicted membrane protein [Function unknown]; Region: COG4244 43989010867 Predicted membrane protein [Function unknown]; Region: COG4244 43989010868 Predicted membrane protein [Function unknown]; Region: COG4244 43989010869 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 43989010870 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 43989010871 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 43989010872 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 43989010873 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 43989010874 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 43989010875 Subunit I/III interface [polypeptide binding]; other site 43989010876 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 43989010877 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 43989010878 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 43989010879 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 43989010880 Walker A/P-loop; other site 43989010881 ATP binding site [chemical binding]; other site 43989010882 Q-loop/lid; other site 43989010883 ABC transporter signature motif; other site 43989010884 Walker B; other site 43989010885 D-loop; other site 43989010886 H-loop/switch region; other site 43989010887 DevC protein; Region: devC; TIGR01185 43989010888 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 43989010889 FtsX-like permease family; Region: FtsX; pfam02687 43989010890 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 43989010891 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 43989010892 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 43989010893 HlyD family secretion protein; Region: HlyD_3; pfam13437 43989010894 Repair protein; Region: Repair_PSII; pfam04536 43989010895 acyl carrier protein; Provisional; Region: acpP; PRK00982 43989010896 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 43989010897 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 43989010898 dimer interface [polypeptide binding]; other site 43989010899 active site 43989010900 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 43989010901 Peptidase family M50; Region: Peptidase_M50; pfam02163 43989010902 active site 43989010903 putative substrate binding region [chemical binding]; other site 43989010904 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 43989010905 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 43989010906 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 43989010907 P-loop; other site 43989010908 Magnesium ion binding site [ion binding]; other site 43989010909 hypothetical protein; Validated; Region: PRK09039 43989010910 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 43989010911 UbiA prenyltransferase family; Region: UbiA; pfam01040 43989010912 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 43989010913 16S/18S rRNA binding site [nucleotide binding]; other site 43989010914 S13e-L30e interaction site [polypeptide binding]; other site 43989010915 25S rRNA binding site [nucleotide binding]; other site 43989010916 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 43989010917 putative catalytic residues [active] 43989010918 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 43989010919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 43989010920 dimer interface [polypeptide binding]; other site 43989010921 conserved gate region; other site 43989010922 putative PBP binding loops; other site 43989010923 ABC-ATPase subunit interface; other site 43989010924 Predicted integral membrane protein [Function unknown]; Region: COG5542 43989010925 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989010926 S-layer homology domain; Region: SLH; pfam00395 43989010927 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 43989010928 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 43989010929 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 43989010930 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 43989010931 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 43989010932 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 43989010933 c-type cytochrome biogenensis protein; Validated; Region: ccs1; CHL00177 43989010934 ResB-like family; Region: ResB; pfam05140 43989010935 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 43989010936 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 43989010937 Lipase (class 2); Region: Lipase_2; pfam01674 43989010938 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 43989010939 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 43989010940 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 43989010941 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989010942 TPR motif; other site 43989010943 binding surface 43989010944 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 43989010945 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 43989010946 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 43989010947 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 43989010948 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 43989010949 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 43989010950 catalytic residues [active] 43989010951 Putative zinc-finger; Region: zf-HC2; pfam13490 43989010952 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 43989010953 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 43989010954 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 43989010955 DNA binding residues [nucleotide binding] 43989010956 Late competence development protein ComFB; Region: ComFB; pfam10719 43989010957 Sm and related proteins; Region: Sm_like; cl00259 43989010958 heptamer interface [polypeptide binding]; other site 43989010959 Sm1 motif; other site 43989010960 hexamer interface [polypeptide binding]; other site 43989010961 RNA binding site [nucleotide binding]; other site 43989010962 Sm2 motif; other site 43989010963 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 43989010964 diaminopimelate epimerase; Region: PLN02536 43989010965 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 43989010966 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 43989010967 phosphopeptide binding site; other site 43989010968 Transglycosylase; Region: Transgly; pfam00912 43989010969 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 43989010970 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 43989010971 YCII-related domain; Region: YCII; cl00999 43989010972 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 43989010973 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989010974 S-adenosylmethionine binding site [chemical binding]; other site 43989010975 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 43989010976 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 43989010977 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 43989010978 substrate-cofactor binding pocket; other site 43989010979 pyridoxal 5'-phosphate binding site [chemical binding]; other site 43989010980 catalytic residue [active] 43989010981 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 43989010982 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 43989010983 dimer interface [polypeptide binding]; other site 43989010984 anticodon binding site; other site 43989010985 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 43989010986 homodimer interface [polypeptide binding]; other site 43989010987 motif 1; other site 43989010988 active site 43989010989 motif 2; other site 43989010990 GAD domain; Region: GAD; pfam02938 43989010991 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 43989010992 active site 43989010993 motif 3; other site 43989010994 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 43989010995 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 43989010996 Predicted permease; Region: DUF318; cl17795 43989010997 acylphosphatase; Provisional; Region: PRK14423 43989010998 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 43989010999 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 43989011000 ligand binding site [chemical binding]; other site 43989011001 flexible hinge region; other site 43989011002 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 43989011003 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 43989011004 ligand binding site [chemical binding]; other site 43989011005 flexible hinge region; other site 43989011006 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 43989011007 catalytic core [active] 43989011008 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 43989011009 catalytic core [active] 43989011010 TPR repeat; Region: TPR_11; pfam13414 43989011011 Tetratricopeptide repeat; Region: TPR_2; pfam07719 43989011012 binding surface 43989011013 TPR motif; other site 43989011014 FOG: CBS domain [General function prediction only]; Region: COG0517 43989011015 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 43989011016 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 43989011017 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 43989011018 putative substrate binding site [chemical binding]; other site 43989011019 putative ATP binding site [chemical binding]; other site 43989011020 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 43989011021 ABC1 family; Region: ABC1; cl17513 43989011022 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 43989011023 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 43989011024 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989011025 active site 43989011026 phosphorylation site [posttranslational modification] 43989011027 intermolecular recognition site; other site 43989011028 dimerization interface [polypeptide binding]; other site 43989011029 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 43989011030 DNA binding residues [nucleotide binding] 43989011031 dimerization interface [polypeptide binding]; other site 43989011032 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 43989011033 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 43989011034 phosphopeptide binding site; other site 43989011035 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 43989011036 metal binding site [ion binding]; metal-binding site 43989011037 active site 43989011038 I-site; other site 43989011039 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 43989011040 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 43989011041 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 43989011042 phosphopeptide binding site; other site 43989011043 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 43989011044 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 43989011045 metal binding site [ion binding]; metal-binding site 43989011046 active site 43989011047 I-site; other site 43989011048 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 43989011049 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 43989011050 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 43989011051 phosphopeptide binding site; other site 43989011052 PAS domain S-box; Region: sensory_box; TIGR00229 43989011053 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989011054 putative active site [active] 43989011055 heme pocket [chemical binding]; other site 43989011056 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 43989011057 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 43989011058 metal binding site [ion binding]; metal-binding site 43989011059 active site 43989011060 I-site; other site 43989011061 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 43989011062 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 43989011063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989011064 active site 43989011065 phosphorylation site [posttranslational modification] 43989011066 intermolecular recognition site; other site 43989011067 dimerization interface [polypeptide binding]; other site 43989011068 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 43989011069 DNA binding residues [nucleotide binding] 43989011070 dimerization interface [polypeptide binding]; other site 43989011071 Uncharacterized conserved protein [Function unknown]; Region: COG3339 43989011072 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 43989011073 Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...; Region: ADA_AMPD; cd00443 43989011074 active site 43989011075 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 43989011076 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 43989011077 putative metal binding site; other site 43989011078 peptide chain release factor 2; Validated; Region: prfB; PRK00578 43989011079 This domain is found in peptide chain release factors; Region: PCRF; smart00937 43989011080 RF-1 domain; Region: RF-1; pfam00472 43989011081 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 43989011082 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 43989011083 SLBB domain; Region: SLBB; pfam10531 43989011084 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 43989011085 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 43989011086 putative binding surface; other site 43989011087 active site 43989011088 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 43989011089 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 43989011090 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 43989011091 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989011092 ATP binding site [chemical binding]; other site 43989011093 Mg2+ binding site [ion binding]; other site 43989011094 G-X-G motif; other site 43989011095 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 43989011096 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 43989011097 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989011098 active site 43989011099 phosphorylation site [posttranslational modification] 43989011100 intermolecular recognition site; other site 43989011101 dimerization interface [polypeptide binding]; other site 43989011102 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 43989011103 dimerization interface [polypeptide binding]; other site 43989011104 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 43989011105 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 43989011106 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 43989011107 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 43989011108 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 43989011109 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 43989011110 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 43989011111 dimer interface [polypeptide binding]; other site 43989011112 putative CheW interface [polypeptide binding]; other site 43989011113 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 43989011114 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 43989011115 dimerization interface [polypeptide binding]; other site 43989011116 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 43989011117 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 43989011118 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 43989011119 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 43989011120 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 43989011121 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 43989011122 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 43989011123 dimer interface [polypeptide binding]; other site 43989011124 putative CheW interface [polypeptide binding]; other site 43989011125 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 43989011126 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 43989011127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989011128 active site 43989011129 phosphorylation site [posttranslational modification] 43989011130 intermolecular recognition site; other site 43989011131 dimerization interface [polypeptide binding]; other site 43989011132 Response regulator receiver domain; Region: Response_reg; pfam00072 43989011133 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989011134 active site 43989011135 phosphorylation site [posttranslational modification] 43989011136 intermolecular recognition site; other site 43989011137 dimerization interface [polypeptide binding]; other site 43989011138 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 43989011139 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 43989011140 dimer interface [polypeptide binding]; other site 43989011141 putative functional site; other site 43989011142 putative MPT binding site; other site 43989011143 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 43989011144 phosphopeptide binding site; other site 43989011145 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 43989011146 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 43989011147 phosphopeptide binding site; other site 43989011148 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 43989011149 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 43989011150 Walker A/P-loop; other site 43989011151 ATP binding site [chemical binding]; other site 43989011152 Q-loop/lid; other site 43989011153 ABC transporter signature motif; other site 43989011154 Walker B; other site 43989011155 D-loop; other site 43989011156 H-loop/switch region; other site 43989011157 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 43989011158 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 43989011159 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 43989011160 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 43989011161 Tetramer interface [polypeptide binding]; other site 43989011162 active site 43989011163 FMN-binding site [chemical binding]; other site 43989011164 Domain of unknown function DUF29; Region: DUF29; pfam01724 43989011165 hybrid cluster protein; Provisional; Region: PRK05290 43989011166 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 43989011167 ACS interaction site; other site 43989011168 CODH interaction site; other site 43989011169 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 43989011170 ACS interaction site; other site 43989011171 CODH interaction site; other site 43989011172 metal cluster binding site [ion binding]; other site 43989011173 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 43989011174 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 43989011175 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989011176 dimer interface [polypeptide binding]; other site 43989011177 phosphorylation site [posttranslational modification] 43989011178 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 43989011179 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 43989011180 Coenzyme A binding pocket [chemical binding]; other site 43989011181 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 43989011182 NlpC/P60 family; Region: NLPC_P60; pfam00877 43989011183 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 43989011184 DHH family; Region: DHH; pfam01368 43989011185 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 43989011186 FOG: CBS domain [General function prediction only]; Region: COG0517 43989011187 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 43989011188 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 43989011189 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 43989011190 active site 43989011191 NTP binding site [chemical binding]; other site 43989011192 metal binding triad [ion binding]; metal-binding site 43989011193 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 43989011194 Class I aldolases; Region: Aldolase_Class_I; cl17187 43989011195 catalytic residue [active] 43989011196 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989011197 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989011198 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 43989011199 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989011200 Uncharacterized conserved protein [Function unknown]; Region: COG0397 43989011201 hypothetical protein; Validated; Region: PRK00029 43989011202 Nuclease-related domain; Region: NERD; pfam08378 43989011203 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 43989011204 Family description; Region: UvrD_C_2; pfam13538 43989011205 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 43989011206 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989011207 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 43989011208 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 43989011209 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 43989011210 phosphate binding site [ion binding]; other site 43989011211 putative substrate binding pocket [chemical binding]; other site 43989011212 dimer interface [polypeptide binding]; other site 43989011213 Predicted ATPases [General function prediction only]; Region: COG1106 43989011214 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 43989011215 Walker A/P-loop; other site 43989011216 ATP binding site [chemical binding]; other site 43989011217 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 43989011218 ABC transporter signature motif; other site 43989011219 Walker B; other site 43989011220 D-loop; other site 43989011221 H-loop/switch region; other site 43989011222 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 43989011223 Phosphoglycerate kinase; Region: PGK; pfam00162 43989011224 substrate binding site [chemical binding]; other site 43989011225 hinge regions; other site 43989011226 ADP binding site [chemical binding]; other site 43989011227 catalytic site [active] 43989011228 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 43989011229 Ligand Binding Site [chemical binding]; other site 43989011230 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 43989011231 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 43989011232 GDP-binding site [chemical binding]; other site 43989011233 ACT binding site; other site 43989011234 IMP binding site; other site 43989011235 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 43989011236 5S rRNA interface [nucleotide binding]; other site 43989011237 CTC domain interface [polypeptide binding]; other site 43989011238 L16 interface [polypeptide binding]; other site 43989011239 Neurotransmitter-gated ion-channel ligand binding domain; Region: Neur_chan_LBD; pfam02931 43989011240 Neurotransmitter-gated ion-channel transmembrane region; Region: Neur_chan_memb; pfam02932 43989011241 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 43989011242 putative active site [active] 43989011243 acetolactate synthase; Reviewed; Region: PRK08322 43989011244 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 43989011245 PYR/PP interface [polypeptide binding]; other site 43989011246 dimer interface [polypeptide binding]; other site 43989011247 TPP binding site [chemical binding]; other site 43989011248 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 43989011249 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 43989011250 TPP-binding site [chemical binding]; other site 43989011251 dimer interface [polypeptide binding]; other site 43989011252 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 43989011253 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 43989011254 NAD(P) binding site [chemical binding]; other site 43989011255 catalytic residues [active] 43989011256 DDE superfamily endonuclease; Region: DDE_3; pfam13358 43989011257 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 43989011258 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 43989011259 Homeodomain-like domain; Region: HTH_32; pfam13565 43989011260 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989011261 putative active site [active] 43989011262 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 43989011263 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 43989011264 NAD(P) binding site [chemical binding]; other site 43989011265 active site 43989011266 Ebola nucleoprotein; Region: Ebola_NP; pfam05505 43989011267 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 43989011268 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 43989011269 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 43989011270 HIGH motif; other site 43989011271 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 43989011272 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 43989011273 active site 43989011274 KMSKS motif; other site 43989011275 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 43989011276 tRNA binding surface [nucleotide binding]; other site 43989011277 AIPR protein; Region: AIPR; pfam10592 43989011278 Uncharacterized conserved protein [Function unknown]; Region: COG5464 43989011279 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 43989011280 Homeodomain-like domain; Region: HTH_23; pfam13384 43989011281 DDE superfamily endonuclease; Region: DDE_3; pfam13358 43989011282 Uncharacterized conserved protein [Function unknown]; Region: COG5464 43989011283 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 43989011284 Homeodomain-like domain; Region: HTH_23; cl17451 43989011285 Homeodomain-like domain; Region: HTH_32; pfam13565 43989011286 DDE superfamily endonuclease; Region: DDE_3; pfam13358 43989011287 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 43989011288 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 43989011289 Clp protease ATP binding subunit; Region: clpC; CHL00095 43989011290 Clp amino terminal domain; Region: Clp_N; pfam02861 43989011291 Clp amino terminal domain; Region: Clp_N; pfam02861 43989011292 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 43989011293 Walker A motif; other site 43989011294 ATP binding site [chemical binding]; other site 43989011295 Walker B motif; other site 43989011296 arginine finger; other site 43989011297 UvrB/uvrC motif; Region: UVR; pfam02151 43989011298 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 43989011299 Walker A motif; other site 43989011300 ATP binding site [chemical binding]; other site 43989011301 Walker B motif; other site 43989011302 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 43989011303 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 43989011304 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 43989011305 Domain of unknown function DUF29; Region: DUF29; pfam01724 43989011306 competence damage-inducible protein A; Provisional; Region: PRK00549 43989011307 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 43989011308 putative MPT binding site; other site 43989011309 Competence-damaged protein; Region: CinA; pfam02464 43989011310 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 43989011311 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 43989011312 active site 43989011313 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 43989011314 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 43989011315 putative active site; other site 43989011316 catalytic residue [active] 43989011317 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 43989011318 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 43989011319 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 43989011320 protein binding site [polypeptide binding]; other site 43989011321 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 43989011322 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989011323 S-adenosylmethionine binding site [chemical binding]; other site 43989011324 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 43989011325 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 43989011326 active site 43989011327 HIGH motif; other site 43989011328 nucleotide binding site [chemical binding]; other site 43989011329 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 43989011330 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 43989011331 active site 43989011332 KMSKS motif; other site 43989011333 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 43989011334 tRNA binding surface [nucleotide binding]; other site 43989011335 anticodon binding site; other site 43989011336 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 43989011337 Domain of unknown function DUF29; Region: DUF29; pfam01724 43989011338 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 43989011339 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 43989011340 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 43989011341 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 43989011342 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 43989011343 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 43989011344 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 43989011345 active site 43989011346 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 43989011347 Uncharacterized conserved protein [Function unknown]; Region: COG1656 43989011348 Protein of unknown function DUF82; Region: DUF82; pfam01927 43989011349 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 43989011350 phosphatidate cytidylyltransferase; Region: PLN02953 43989011351 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 43989011352 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989011353 S-adenosylmethionine binding site [chemical binding]; other site 43989011354 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 43989011355 sulfotransferase; Region: PLN02164 43989011356 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 43989011357 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989011358 putative active site [active] 43989011359 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 43989011360 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989011361 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989011362 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989011363 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989011364 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989011365 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989011366 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 43989011367 Ligand Binding Site [chemical binding]; other site 43989011368 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 43989011369 Ligand Binding Site [chemical binding]; other site 43989011370 Photosystem I protein M (PsaM); Region: PsaM; pfam07465 43989011371 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 43989011372 Uncharacterized conserved protein [Function unknown]; Region: COG5464 43989011373 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 43989011374 Uncharacterized conserved protein [Function unknown]; Region: COG5464 43989011375 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 43989011376 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 43989011377 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 43989011378 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 43989011379 putative trimer interface [polypeptide binding]; other site 43989011380 putative CoA binding site [chemical binding]; other site 43989011381 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 43989011382 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 43989011383 trimer interface [polypeptide binding]; other site 43989011384 active site 43989011385 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 43989011386 putative multimerization interface [polypeptide binding]; other site 43989011387 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 43989011388 putative multimerization interface [polypeptide binding]; other site 43989011389 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 43989011390 putative multimerization interface [polypeptide binding]; other site 43989011391 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 43989011392 putative multimerization interface [polypeptide binding]; other site 43989011393 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 43989011394 Hexamer/Pentamer interface [polypeptide binding]; other site 43989011395 central pore; other site 43989011396 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 43989011397 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 43989011398 Hexamer interface [polypeptide binding]; other site 43989011399 Hexagonal pore residue; other site 43989011400 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 43989011401 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 43989011402 Hexamer interface [polypeptide binding]; other site 43989011403 Hexagonal pore residue; other site 43989011404 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 43989011405 putative rRNA binding site [nucleotide binding]; other site 43989011406 Biofilm formation and stress response factor; Region: BsmA; pfam10014 43989011407 Response regulator receiver domain; Region: Response_reg; pfam00072 43989011408 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989011409 active site 43989011410 phosphorylation site [posttranslational modification] 43989011411 intermolecular recognition site; other site 43989011412 dimerization interface [polypeptide binding]; other site 43989011413 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 43989011414 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 43989011415 metal binding site [ion binding]; metal-binding site 43989011416 active site 43989011417 I-site; other site 43989011418 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 43989011419 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 43989011420 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 43989011421 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 43989011422 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989011423 dimer interface [polypeptide binding]; other site 43989011424 phosphorylation site [posttranslational modification] 43989011425 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989011426 ATP binding site [chemical binding]; other site 43989011427 Mg2+ binding site [ion binding]; other site 43989011428 G-X-G motif; other site 43989011429 Response regulator receiver domain; Region: Response_reg; pfam00072 43989011430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989011431 active site 43989011432 phosphorylation site [posttranslational modification] 43989011433 intermolecular recognition site; other site 43989011434 dimerization interface [polypeptide binding]; other site 43989011435 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 43989011436 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 43989011437 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 43989011438 active site 43989011439 catalytic triad [active] 43989011440 GUN4-like; Region: GUN4; pfam05419 43989011441 Methyltransferase domain; Region: Methyltransf_31; pfam13847 43989011442 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989011443 S-adenosylmethionine binding site [chemical binding]; other site 43989011444 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 43989011445 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 43989011446 FeS/SAM binding site; other site 43989011447 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 43989011448 Uncharacterized conserved protein [Function unknown]; Region: COG0398 43989011449 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 43989011450 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546 43989011451 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 43989011452 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 43989011453 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 43989011454 Protein of unknown function (DUF512); Region: DUF512; pfam04459 43989011455 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 43989011456 O-Antigen ligase; Region: Wzy_C; pfam04932 43989011457 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 43989011458 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 43989011459 triosephosphate isomerase; Provisional; Region: PRK14565 43989011460 substrate binding site [chemical binding]; other site 43989011461 dimer interface [polypeptide binding]; other site 43989011462 catalytic triad [active] 43989011463 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 43989011464 dihydropteroate synthase; Region: DHPS; TIGR01496 43989011465 substrate binding pocket [chemical binding]; other site 43989011466 dimer interface [polypeptide binding]; other site 43989011467 inhibitor binding site; inhibition site 43989011468 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 43989011469 FAD binding domain; Region: FAD_binding_4; pfam01565 43989011470 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 43989011471 alpha-dioxygenase; Region: PLN02283 43989011472 Animal heme oxidases similar to plant pathogen-inducible oxygenases; Region: PIOX_like; cd09818 43989011473 putative heme binding site [chemical binding]; other site 43989011474 putative active site [active] 43989011475 putative substrate binding site [chemical binding]; other site 43989011476 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 43989011477 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 43989011478 putative active site [active] 43989011479 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 43989011480 putative active site [active] 43989011481 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765 43989011482 DNA photolyase; Region: DNA_photolyase; pfam00875 43989011483 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 43989011484 DNA binding residues [nucleotide binding] 43989011485 Domain of unknown function (DUF3893); Region: DUF3893; pfam13032 43989011486 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 43989011487 heterotetramer interface [polypeptide binding]; other site 43989011488 active site pocket [active] 43989011489 cleavage site 43989011490 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 43989011491 dimerization interface [polypeptide binding]; other site 43989011492 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 43989011493 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 43989011494 dimer interface [polypeptide binding]; other site 43989011495 putative CheW interface [polypeptide binding]; other site 43989011496 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 43989011497 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 43989011498 putative binding surface; other site 43989011499 active site 43989011500 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 43989011501 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989011502 ATP binding site [chemical binding]; other site 43989011503 Mg2+ binding site [ion binding]; other site 43989011504 G-X-G motif; other site 43989011505 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 43989011506 Response regulator receiver domain; Region: Response_reg; pfam00072 43989011507 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989011508 active site 43989011509 phosphorylation site [posttranslational modification] 43989011510 intermolecular recognition site; other site 43989011511 dimerization interface [polypeptide binding]; other site 43989011512 CheW-like domain; Region: CheW; pfam01584 43989011513 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 43989011514 nucleotide binding site [chemical binding]; other site 43989011515 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 43989011516 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 43989011517 ATP binding site [chemical binding]; other site 43989011518 putative Mg++ binding site [ion binding]; other site 43989011519 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 43989011520 nucleotide binding region [chemical binding]; other site 43989011521 ATP-binding site [chemical binding]; other site 43989011522 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 43989011523 NACHT domain; Region: NACHT; pfam05729 43989011524 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 43989011525 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 43989011526 DNA binding site [nucleotide binding] 43989011527 catalytic residue [active] 43989011528 H2TH interface [polypeptide binding]; other site 43989011529 putative catalytic residues [active] 43989011530 turnover-facilitating residue; other site 43989011531 intercalation triad [nucleotide binding]; other site 43989011532 8OG recognition residue [nucleotide binding]; other site 43989011533 putative reading head residues; other site 43989011534 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 43989011535 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 43989011536 photosystem I reaction center subunit IV; Provisional; Region: PRK02749 43989011537 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 43989011538 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 43989011539 active site 43989011540 catalytic tetrad [active] 43989011541 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 43989011542 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 43989011543 active site 43989011544 zinc binding site [ion binding]; other site 43989011545 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 43989011546 dimer interface [polypeptide binding]; other site 43989011547 substrate binding site [chemical binding]; other site 43989011548 metal binding sites [ion binding]; metal-binding site 43989011549 Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664 43989011550 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 43989011551 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989011552 putative active site [active] 43989011553 Winged helix-turn helix; Region: HTH_29; pfam13551 43989011554 Winged helix-turn helix; Region: HTH_33; pfam13592 43989011555 DDE superfamily endonuclease; Region: DDE_3; pfam13358 43989011556 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 43989011557 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 43989011558 RNA methyltransferase, RsmE family; Region: TIGR00046 43989011559 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 43989011560 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 43989011561 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 43989011562 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 43989011563 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 43989011564 Selenophosphate synthase [Amino acid transport and metabolism]; Region: SelD; COG0709 43989011565 dimerization interface [polypeptide binding]; other site 43989011566 putative ATP binding site [chemical binding]; other site 43989011567 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 43989011568 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 43989011569 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 43989011570 Predicted membrane protein [Function unknown]; Region: COG3463 43989011571 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 43989011572 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 43989011573 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 43989011574 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 43989011575 Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655 43989011576 Uncharacterized conserved protein [Function unknown]; Region: COG2361 43989011577 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 43989011578 active site 43989011579 NTP binding site [chemical binding]; other site 43989011580 metal binding triad [ion binding]; metal-binding site 43989011581 antibiotic binding site [chemical binding]; other site 43989011582 biotin synthase; Region: bioB; TIGR00433 43989011583 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 43989011584 FeS/SAM binding site; other site 43989011585 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 43989011586 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 43989011587 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 43989011588 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 43989011589 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 43989011590 active site 43989011591 dimer interface [polypeptide binding]; other site 43989011592 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 43989011593 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 43989011594 active site 43989011595 FMN binding site [chemical binding]; other site 43989011596 substrate binding site [chemical binding]; other site 43989011597 3Fe-4S cluster binding site [ion binding]; other site 43989011598 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 43989011599 domain interface; other site 43989011600 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 43989011601 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 43989011602 purine monophosphate binding site [chemical binding]; other site 43989011603 dimer interface [polypeptide binding]; other site 43989011604 putative catalytic residues [active] 43989011605 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 43989011606 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 43989011607 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 43989011608 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 43989011609 Malic enzyme, N-terminal domain; Region: malic; pfam00390 43989011610 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 43989011611 putative NAD(P) binding site [chemical binding]; other site 43989011612 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 43989011613 Methyltransferase domain; Region: Methyltransf_31; pfam13847 43989011614 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989011615 S-adenosylmethionine binding site [chemical binding]; other site 43989011616 magnesium chelatase subunit H; Provisional; Region: PRK12493 43989011617 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 43989011618 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 43989011619 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 43989011620 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 43989011621 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 43989011622 active site 43989011623 TRAM domain; Region: TRAM; cl01282 43989011624 Protein of unknown function DUF262; Region: DUF262; pfam03235 43989011625 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 43989011626 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 43989011627 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 43989011628 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 43989011629 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 43989011630 B12 binding site [chemical binding]; other site 43989011631 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 43989011632 FeS/SAM binding site; other site 43989011633 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 43989011634 argininosuccinate synthase; Provisional; Region: PRK13820 43989011635 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 43989011636 ANP binding site [chemical binding]; other site 43989011637 Substrate Binding Site II [chemical binding]; other site 43989011638 Substrate Binding Site I [chemical binding]; other site 43989011639 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 43989011640 nucleotide binding site [chemical binding]; other site 43989011641 Protein of unknown function (DUF433); Region: DUF433; pfam04255 43989011642 PhoD-like phosphatase; Region: PhoD; pfam09423 43989011643 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 43989011644 putative active site [active] 43989011645 putative metal binding site [ion binding]; other site 43989011646 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 43989011647 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360 43989011648 ATP adenylyltransferase; Region: ATP_transf; pfam09830 43989011649 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 43989011650 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 43989011651 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 43989011652 domain interfaces; other site 43989011653 active site 43989011654 hypothetical protein; Validated; Region: PRK00153 43989011655 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 43989011656 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 43989011657 Cl- selectivity filter; other site 43989011658 Cl- binding residues [ion binding]; other site 43989011659 pore gating glutamate residue; other site 43989011660 Mechanosensitive ion channel; Region: MS_channel; pfam00924 43989011661 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 43989011662 DNA polymerase III subunit delta'; Validated; Region: PRK07399 43989011663 DNA polymerase III subunit delta'; Validated; Region: PRK08485 43989011664 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 43989011665 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 43989011666 phosphopeptide binding site; other site 43989011667 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 43989011668 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 43989011669 metal-binding site [ion binding] 43989011670 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 43989011671 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 43989011672 motif II; other site 43989011673 Protein of unknown function (DUF2489); Region: DUF2489; pfam10675 43989011674 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 43989011675 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 43989011676 putative di-iron ligands [ion binding]; other site 43989011677 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 43989011678 RNA/DNA hybrid binding site [nucleotide binding]; other site 43989011679 active site 43989011680 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 43989011681 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 43989011682 Zn2+ binding site [ion binding]; other site 43989011683 Mg2+ binding site [ion binding]; other site 43989011684 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 43989011685 synthetase active site [active] 43989011686 NTP binding site [chemical binding]; other site 43989011687 metal binding site [ion binding]; metal-binding site 43989011688 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 43989011689 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 43989011690 Putative capsular polysaccharide synthesis protein; Region: NKWYS; pfam10364 43989011691 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 43989011692 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 43989011693 [2Fe-2S] cluster binding site [ion binding]; other site 43989011694 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 43989011695 hydrophobic ligand binding site; other site 43989011696 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 43989011697 dimerization interface [polypeptide binding]; other site 43989011698 putative DNA binding site [nucleotide binding]; other site 43989011699 putative Zn2+ binding site [ion binding]; other site 43989011700 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 43989011701 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989011702 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989011703 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989011704 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989011705 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989011706 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 43989011707 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 43989011708 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 43989011709 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 43989011710 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 43989011711 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 43989011712 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 43989011713 DNA gyrase subunit A; Validated; Region: PRK05560 43989011714 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 43989011715 CAP-like domain; other site 43989011716 active site 43989011717 primary dimer interface [polypeptide binding]; other site 43989011718 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 43989011719 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 43989011720 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 43989011721 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 43989011722 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 43989011723 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 43989011724 TspO/MBR family; Region: TspO_MBR; cl01379 43989011725 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 43989011726 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989011727 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989011728 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 43989011729 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989011730 Cupin domain; Region: Cupin_2; cl17218 43989011731 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 43989011732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989011733 active site 43989011734 phosphorylation site [posttranslational modification] 43989011735 intermolecular recognition site; other site 43989011736 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 43989011737 dimerization interface [polypeptide binding]; other site 43989011738 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989011739 dimer interface [polypeptide binding]; other site 43989011740 phosphorylation site [posttranslational modification] 43989011741 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989011742 ATP binding site [chemical binding]; other site 43989011743 Mg2+ binding site [ion binding]; other site 43989011744 G-X-G motif; other site 43989011745 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 43989011746 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 43989011747 Uncharacterized conserved protein [Function unknown]; Region: COG0432 43989011748 Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066 43989011749 nickel binding site [ion binding]; other site 43989011750 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 43989011751 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 43989011752 metal binding site [ion binding]; metal-binding site 43989011753 substrate binding pocket [chemical binding]; other site 43989011754 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989011755 putative active site [active] 43989011756 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 43989011757 diiron binding motif [ion binding]; other site 43989011758 Cytochrome P450; Region: p450; cl12078 43989011759 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 43989011760 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 43989011761 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 43989011762 putative active site [active] 43989011763 catalytic site [active] 43989011764 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 43989011765 putative active site [active] 43989011766 catalytic site [active] 43989011767 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 43989011768 Helix-hairpin-helix motif; Region: HHH; pfam00633 43989011769 Cobalt transport protein; Region: CbiQ; cl00463 43989011770 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 43989011771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989011772 active site 43989011773 phosphorylation site [posttranslational modification] 43989011774 intermolecular recognition site; other site 43989011775 dimerization interface [polypeptide binding]; other site 43989011776 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 43989011777 DNA binding site [nucleotide binding] 43989011778 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 43989011779 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 43989011780 homodimer interface [polypeptide binding]; other site 43989011781 pyridoxal 5'-phosphate binding site [chemical binding]; other site 43989011782 catalytic residue [active] 43989011783 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 43989011784 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 43989011785 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 43989011786 homooctamer interface [polypeptide binding]; other site 43989011787 active site 43989011788 Rhomboid family; Region: Rhomboid; pfam01694 43989011789 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 43989011790 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 43989011791 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 43989011792 active site 43989011793 putative lithium-binding site [ion binding]; other site 43989011794 substrate binding site [chemical binding]; other site 43989011795 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 43989011796 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 43989011797 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 43989011798 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 43989011799 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 43989011800 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989011801 dimer interface [polypeptide binding]; other site 43989011802 phosphorylation site [posttranslational modification] 43989011803 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989011804 ATP binding site [chemical binding]; other site 43989011805 Mg2+ binding site [ion binding]; other site 43989011806 G-X-G motif; other site 43989011807 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 43989011808 photosystem II stability/assembly factor; Provisional; Region: PLN00033 43989011809 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 43989011810 glutamine synthetase, type I; Region: GlnA; TIGR00653 43989011811 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 43989011812 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 43989011813 helicase 45; Provisional; Region: PTZ00424 43989011814 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 43989011815 ATP binding site [chemical binding]; other site 43989011816 Mg++ binding site [ion binding]; other site 43989011817 motif III; other site 43989011818 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 43989011819 nucleotide binding region [chemical binding]; other site 43989011820 ATP-binding site [chemical binding]; other site 43989011821 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 43989011822 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 43989011823 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 43989011824 FeS/SAM binding site; other site 43989011825 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 43989011826 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 43989011827 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 43989011828 Walker A motif; other site 43989011829 ATP binding site [chemical binding]; other site 43989011830 Walker B motif; other site 43989011831 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 43989011832 Clp protease; Region: CLP_protease; pfam00574 43989011833 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 43989011834 oligomer interface [polypeptide binding]; other site 43989011835 active site residues [active] 43989011836 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 43989011837 active site 43989011838 dimer interface [polypeptide binding]; other site 43989011839 metal binding site [ion binding]; metal-binding site 43989011840 Photosystem II reaction centre N protein (psbN); Region: PsbN; pfam02468 43989011841 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 43989011842 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 43989011843 ATP binding site [chemical binding]; other site 43989011844 putative Mg++ binding site [ion binding]; other site 43989011845 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 43989011846 nucleotide binding region [chemical binding]; other site 43989011847 ATP-binding site [chemical binding]; other site 43989011848 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 43989011849 cytochrome b6-f complex subunit PetN; Provisional; Region: PRK14747 43989011850 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 43989011851 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 43989011852 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 43989011853 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 43989011854 active site 43989011855 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 43989011856 UbiA prenyltransferase family; Region: UbiA; pfam01040 43989011857 Dehydroquinate synthase (DHQS)-like. DHQS catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS-like2; cd08198 43989011858 active site 43989011859 metal binding site [ion binding]; metal-binding site 43989011860 Uncharacterized conserved protein [Function unknown]; Region: COG3379 43989011861 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 43989011862 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 43989011863 prolyl-tRNA synthetase; Provisional; Region: PRK09194 43989011864 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 43989011865 dimer interface [polypeptide binding]; other site 43989011866 motif 1; other site 43989011867 active site 43989011868 motif 2; other site 43989011869 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 43989011870 putative deacylase active site [active] 43989011871 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 43989011872 active site 43989011873 motif 3; other site 43989011874 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 43989011875 anticodon binding site; other site 43989011876 Late competence development protein ComFB; Region: ComFB; pfam10719 43989011877 arogenate dehydrogenase; Reviewed; Region: PRK07417 43989011878 prephenate dehydrogenase; Validated; Region: PRK08507 43989011879 HAS barrel domain; Region: HAS-barrel; pfam09378 43989011880 HerA helicase [Replication, recombination, and repair]; Region: COG0433 43989011881 Domain of unknown function DUF87; Region: DUF87; pfam01935 43989011882 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 43989011883 oligomeric interface; other site 43989011884 putative active site [active] 43989011885 homodimer interface [polypeptide binding]; other site 43989011886 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 43989011887 DNA methylase; Region: N6_N4_Mtase; pfam01555 43989011888 Tetratricopeptide repeat; Region: TPR_12; pfam13424 43989011889 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989011890 binding surface 43989011891 TPR motif; other site 43989011892 Tetratricopeptide repeat; Region: TPR_12; pfam13424 43989011893 Tetratricopeptide repeat; Region: TPR_12; pfam13424 43989011894 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989011895 binding surface 43989011896 TPR motif; other site 43989011897 Tetratricopeptide repeat; Region: TPR_12; pfam13424 43989011898 Tetratricopeptide repeat; Region: TPR_12; pfam13424 43989011899 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989011900 TPR motif; other site 43989011901 Tetratricopeptide repeat; Region: TPR_12; pfam13424 43989011902 binding surface 43989011903 CHAT domain; Region: CHAT; pfam12770 43989011904 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 43989011905 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 43989011906 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 43989011907 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 43989011908 shikimate binding site; other site 43989011909 NAD(P) binding site [chemical binding]; other site 43989011910 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 43989011911 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 43989011912 P loop; other site 43989011913 Nucleotide binding site [chemical binding]; other site 43989011914 DTAP/Switch II; other site 43989011915 Switch I; other site 43989011916 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 43989011917 Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184 43989011918 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 43989011919 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 43989011920 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 43989011921 PYR/PP interface [polypeptide binding]; other site 43989011922 dimer interface [polypeptide binding]; other site 43989011923 TPP binding site [chemical binding]; other site 43989011924 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 43989011925 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 43989011926 TPP-binding site [chemical binding]; other site 43989011927 dimer interface [polypeptide binding]; other site 43989011928 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 43989011929 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419 43989011930 UbiA prenyltransferase family; Region: UbiA; pfam01040 43989011931 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 43989011932 chorismate binding enzyme; Region: Chorismate_bind; cl10555 43989011933 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 43989011934 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 43989011935 NeuB family; Region: NeuB; pfam03102 43989011936 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 43989011937 NeuB binding interface [polypeptide binding]; other site 43989011938 putative substrate binding site [chemical binding]; other site 43989011939 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 43989011940 ATP synthase I chain; Region: ATP_synt_I; pfam03899 43989011941 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 43989011942 ATP synthase CF0 A subunit; Region: atpI; CHL00046 43989011943 F0F1 ATP synthase subunit C; Validated; Region: PRK07354 43989011944 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 43989011945 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 43989011946 ATP synthase CF0 B subunit; Region: atpF; CHL00019 43989011947 F0F1 ATP synthase subunit B; Validated; Region: PRK07352 43989011948 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 43989011949 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 43989011950 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 43989011951 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 43989011952 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 43989011953 beta subunit interaction interface [polypeptide binding]; other site 43989011954 Walker A motif; other site 43989011955 ATP binding site [chemical binding]; other site 43989011956 Walker B motif; other site 43989011957 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 43989011958 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 43989011959 core domain interface [polypeptide binding]; other site 43989011960 delta subunit interface [polypeptide binding]; other site 43989011961 epsilon subunit interface [polypeptide binding]; other site 43989011962 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 43989011963 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 43989011964 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 43989011965 putative PBP binding loops; other site 43989011966 dimer interface [polypeptide binding]; other site 43989011967 ABC-ATPase subunit interface; other site 43989011968 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 43989011969 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 43989011970 inhibitor-cofactor binding pocket; inhibition site 43989011971 pyridoxal 5'-phosphate binding site [chemical binding]; other site 43989011972 catalytic residue [active] 43989011973 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 43989011974 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 43989011975 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 43989011976 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 43989011977 active site 43989011978 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 43989011979 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 43989011980 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 43989011981 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 43989011982 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 43989011983 Coenzyme A binding pocket [chemical binding]; other site 43989011984 HEAT repeats; Region: HEAT_2; pfam13646 43989011985 HEAT repeat; Region: HEAT; pfam02985 43989011986 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 43989011987 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 43989011988 active site 43989011989 metal binding site [ion binding]; metal-binding site 43989011990 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 43989011991 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 43989011992 Major Facilitator Superfamily; Region: MFS_1; pfam07690 43989011993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 43989011994 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 43989011995 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 43989011996 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 43989011997 putative dimer interface [polypeptide binding]; other site 43989011998 N-terminal domain interface [polypeptide binding]; other site 43989011999 putative substrate binding pocket (H-site) [chemical binding]; other site 43989012000 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 43989012001 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 43989012002 RNA binding surface [nucleotide binding]; other site 43989012003 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 43989012004 active site 43989012005 Helix-turn-helix domain; Region: HTH_25; pfam13413 43989012006 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 43989012007 Dihaem cytochrome c; Region: DHC; pfam09626 43989012008 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 43989012009 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 43989012010 Active site cavity [active] 43989012011 catalytic acid [active] 43989012012 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 43989012013 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 43989012014 cofactor binding site; other site 43989012015 DNA binding site [nucleotide binding] 43989012016 substrate interaction site [chemical binding]; other site 43989012017 aspartate kinase; Provisional; Region: PRK07431 43989012018 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 43989012019 putative catalytic residues [active] 43989012020 putative nucleotide binding site [chemical binding]; other site 43989012021 putative aspartate binding site [chemical binding]; other site 43989012022 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 43989012023 putative allosteric regulatory site; other site 43989012024 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 43989012025 putative allosteric regulatory residue; other site 43989012026 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 43989012027 putative allosteric regulatory site; other site 43989012028 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 43989012029 Muconolactone delta-isomerase; Region: MIase; cl01992 43989012030 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 43989012031 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 43989012032 photosystem II protein K; Region: psbK; CHL00047 43989012033 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 43989012034 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 43989012035 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 43989012036 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 43989012037 NAD binding site [chemical binding]; other site 43989012038 dimerization interface [polypeptide binding]; other site 43989012039 product binding site; other site 43989012040 substrate binding site [chemical binding]; other site 43989012041 zinc binding site [ion binding]; other site 43989012042 catalytic residues [active] 43989012043 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 43989012044 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 43989012045 Walker A/P-loop; other site 43989012046 ATP binding site [chemical binding]; other site 43989012047 Q-loop/lid; other site 43989012048 ABC transporter signature motif; other site 43989012049 Walker B; other site 43989012050 D-loop; other site 43989012051 H-loop/switch region; other site 43989012052 Ferredoxin [Energy production and conversion]; Region: COG1146 43989012053 ribonuclease PH; Reviewed; Region: rph; PRK00173 43989012054 Ribonuclease PH; Region: RNase_PH_bact; cd11362 43989012055 hexamer interface [polypeptide binding]; other site 43989012056 active site 43989012057 SCP_GAPR-1_like: SCP-like extracellular protein domain, golgi-associated plant pathogenesis related protein (GAPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian...; Region: SCP_GAPR-1_like; cd05382 43989012058 short chain dehydrogenase; Provisional; Region: PRK08303 43989012059 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 43989012060 NAD(P) binding site [chemical binding]; other site 43989012061 active site 43989012062 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 43989012063 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 43989012064 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 43989012065 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 43989012066 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989012067 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989012068 putative active site [active] 43989012069 photochlorophyllide reductase subunit L; Region: chlL; CHL00072 43989012070 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 43989012071 P-loop; other site 43989012072 Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979 43989012073 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 43989012074 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 43989012075 FO synthase subunit 2; Reviewed; Region: PRK07360 43989012076 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 43989012077 FeS/SAM binding site; other site 43989012078 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 43989012079 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit [DNA replication, recombination, and repair]; Region: GyrA; COG0188 43989012080 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 43989012081 CAP-like domain; other site 43989012082 active site 43989012083 primary dimer interface [polypeptide binding]; other site 43989012084 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 43989012085 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 43989012086 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 43989012087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989012088 Response regulator receiver domain; Region: Response_reg; pfam00072 43989012089 active site 43989012090 phosphorylation site [posttranslational modification] 43989012091 intermolecular recognition site; other site 43989012092 dimerization interface [polypeptide binding]; other site 43989012093 Response regulator receiver domain; Region: Response_reg; pfam00072 43989012094 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989012095 active site 43989012096 phosphorylation site [posttranslational modification] 43989012097 intermolecular recognition site; other site 43989012098 dimerization interface [polypeptide binding]; other site 43989012099 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 43989012100 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 43989012101 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 43989012102 HIGH motif; other site 43989012103 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 43989012104 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 43989012105 active site 43989012106 KMSKS motif; other site 43989012107 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 43989012108 tRNA binding surface [nucleotide binding]; other site 43989012109 anticodon binding site; other site 43989012110 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 43989012111 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 43989012112 Recombination protein O N terminal; Region: RecO_N; pfam11967 43989012113 Recombination protein O C terminal; Region: RecO_C; pfam02565 43989012114 Protein of unknown function (DUF751); Region: DUF751; pfam05421 43989012115 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 43989012116 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 43989012117 Walker A/P-loop; other site 43989012118 ATP binding site [chemical binding]; other site 43989012119 Q-loop/lid; other site 43989012120 ABC transporter signature motif; other site 43989012121 Walker B; other site 43989012122 D-loop; other site 43989012123 H-loop/switch region; other site 43989012124 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 43989012125 putative carbohydrate binding site [chemical binding]; other site 43989012126 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 43989012127 Family description; Region: VCBS; pfam13517 43989012128 Family description; Region: VCBS; pfam13517 43989012129 Family description; Region: VCBS; pfam13517 43989012130 Family description; Region: VCBS; pfam13517 43989012131 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 43989012132 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 43989012133 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 43989012134 FMN binding site [chemical binding]; other site 43989012135 dimer interface [polypeptide binding]; other site 43989012136 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 43989012137 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 43989012138 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 43989012139 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 43989012140 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 43989012141 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 43989012142 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 43989012143 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 43989012144 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899 43989012145 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 43989012146 active site 43989012147 DNA binding site [nucleotide binding] 43989012148 Int/Topo IB signature motif; other site 43989012149 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 43989012150 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 43989012151 active site 43989012152 DNA binding site [nucleotide binding] 43989012153 Int/Topo IB signature motif; other site 43989012154 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 43989012155 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 43989012156 active site 43989012157 catalytic residues [active] 43989012158 DNA binding site [nucleotide binding] 43989012159 Int/Topo IB signature motif; other site 43989012160 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 43989012161 replicative DNA helicase; Region: DnaB; TIGR00665 43989012162 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 43989012163 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 43989012164 Walker A motif; other site 43989012165 ATP binding site [chemical binding]; other site 43989012166 Walker B motif; other site 43989012167 DNA binding loops [nucleotide binding] 43989012168 tellurium resistance terB-like protein; Region: terB_like; cl11965 43989012169 metal binding site [ion binding]; metal-binding site 43989012170 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 43989012171 Dynamin family; Region: Dynamin_N; pfam00350 43989012172 G1 box; other site 43989012173 GTP/Mg2+ binding site [chemical binding]; other site 43989012174 G2 box; other site 43989012175 Switch I region; other site 43989012176 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 43989012177 G3 box; other site 43989012178 Switch II region; other site 43989012179 GTP/Mg2+ binding site [chemical binding]; other site 43989012180 G4 box; other site 43989012181 G5 box; other site 43989012182 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 43989012183 Active_site [active] 43989012184 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 43989012185 UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255 43989012186 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 43989012187 NAD binding site [chemical binding]; other site 43989012188 substrate binding site [chemical binding]; other site 43989012189 active site 43989012190 Mechanosensitive ion channel; Region: MS_channel; pfam00924 43989012191 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 43989012192 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 43989012193 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 43989012194 active site 43989012195 metal binding site [ion binding]; metal-binding site 43989012196 DNA binding site [nucleotide binding] 43989012197 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989012198 binding surface 43989012199 TPR motif; other site 43989012200 TPR repeat; Region: TPR_11; pfam13414 43989012201 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 43989012202 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 43989012203 substrate binding pocket [chemical binding]; other site 43989012204 membrane-bound complex binding site; other site 43989012205 hinge residues; other site 43989012206 Response regulator receiver domain; Region: Response_reg; pfam00072 43989012207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989012208 active site 43989012209 phosphorylation site [posttranslational modification] 43989012210 intermolecular recognition site; other site 43989012211 dimerization interface [polypeptide binding]; other site 43989012212 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 43989012213 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 43989012214 metal binding site [ion binding]; metal-binding site 43989012215 active site 43989012216 I-site; other site 43989012217 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 43989012218 HAMP domain; Region: HAMP; pfam00672 43989012219 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989012220 PAS fold; Region: PAS_3; pfam08447 43989012221 putative active site [active] 43989012222 heme pocket [chemical binding]; other site 43989012223 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 43989012224 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989012225 dimer interface [polypeptide binding]; other site 43989012226 phosphorylation site [posttranslational modification] 43989012227 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989012228 ATP binding site [chemical binding]; other site 43989012229 Mg2+ binding site [ion binding]; other site 43989012230 G-X-G motif; other site 43989012231 Response regulator receiver domain; Region: Response_reg; pfam00072 43989012232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989012233 active site 43989012234 phosphorylation site [posttranslational modification] 43989012235 intermolecular recognition site; other site 43989012236 dimerization interface [polypeptide binding]; other site 43989012237 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 43989012238 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989012239 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989012240 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989012241 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989012242 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989012243 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989012244 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989012245 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 43989012246 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989012247 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 43989012248 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 43989012249 substrate binding site [chemical binding]; other site 43989012250 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 43989012251 substrate binding pocket [chemical binding]; other site 43989012252 Ion channel; Region: Ion_trans_2; pfam07885 43989012253 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 43989012254 membrane-bound complex binding site; other site 43989012255 hinge residues; other site 43989012256 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 43989012257 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 43989012258 Mechanosensitive ion channel; Region: MS_channel; pfam00924 43989012259 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 43989012260 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 43989012261 inhibitor-cofactor binding pocket; inhibition site 43989012262 pyridoxal 5'-phosphate binding site [chemical binding]; other site 43989012263 catalytic residue [active] 43989012264 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 43989012265 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 43989012266 hypothetical protein; Provisional; Region: PRK04323 43989012267 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 43989012268 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 43989012269 catalytic site [active] 43989012270 G-X2-G-X-G-K; other site 43989012271 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 43989012272 active site 43989012273 catalytic triad [active] 43989012274 glycogen branching enzyme; Provisional; Region: PRK12313 43989012275 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 43989012276 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 43989012277 active site 43989012278 catalytic site [active] 43989012279 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 43989012280 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 43989012281 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 43989012282 trmE is a tRNA modification GTPase; Region: trmE; cd04164 43989012283 G1 box; other site 43989012284 GTP/Mg2+ binding site [chemical binding]; other site 43989012285 Switch I region; other site 43989012286 G2 box; other site 43989012287 Switch II region; other site 43989012288 G3 box; other site 43989012289 G4 box; other site 43989012290 G5 box; other site 43989012291 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 43989012292 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 43989012293 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 43989012294 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 43989012295 UbiA prenyltransferase family; Region: UbiA; pfam01040 43989012296 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 43989012297 phage shock protein A; Region: phageshock_pspA; TIGR02977 43989012298 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 43989012299 DHH family; Region: DHH; pfam01368 43989012300 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 43989012301 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 43989012302 Penicillin amidase; Region: Penicil_amidase; pfam01804 43989012303 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 43989012304 active site 43989012305 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 43989012306 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 43989012307 active site 43989012308 catalytic residues [active] 43989012309 metal binding site [ion binding]; metal-binding site 43989012310 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 43989012311 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 43989012312 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 43989012313 Ligand binding site; other site 43989012314 Putative Catalytic site; other site 43989012315 DXD motif; other site 43989012316 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 43989012317 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 43989012318 Ligand binding site; other site 43989012319 Putative Catalytic site; other site 43989012320 DXD motif; other site 43989012321 Predicted membrane protein [Function unknown]; Region: COG2246 43989012322 GtrA-like protein; Region: GtrA; pfam04138 43989012323 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 43989012324 active site 43989012325 Domain of unknown function (DUF1824); Region: DUF1824; pfam08854 43989012326 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 43989012327 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 43989012328 Protein of unknown function, DUF479; Region: DUF479; cl01203 43989012329 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 43989012330 Synechococcus sp. strain PCC 7942 PhoA and related proteins, N-terminal metallophosphatase domain; Region: MPP_PhoA_N; cd08162 43989012331 putative active site [active] 43989012332 putative metal binding site [ion binding]; other site 43989012333 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 43989012334 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 43989012335 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 43989012336 putative di-iron ligands [ion binding]; other site 43989012337 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 43989012338 iron-sulfur cluster [ion binding]; other site 43989012339 [2Fe-2S] cluster binding site [ion binding]; other site 43989012340 Pheophorbide a oxygenase; Region: PaO; pfam08417 43989012341 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 43989012342 nudix motif; other site 43989012343 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 43989012344 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 43989012345 generic binding surface I; other site 43989012346 generic binding surface II; other site 43989012347 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 43989012348 putative active site [active] 43989012349 putative catalytic site [active] 43989012350 putative Mg binding site IVb [ion binding]; other site 43989012351 putative phosphate binding site [ion binding]; other site 43989012352 putative DNA binding site [nucleotide binding]; other site 43989012353 putative Mg binding site IVa [ion binding]; other site 43989012354 glutathione reductase; Validated; Region: PRK06116 43989012355 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 43989012356 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 43989012357 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 43989012358 transketolase; Region: PLN02790 43989012359 TPP-binding site [chemical binding]; other site 43989012360 dimer interface [polypeptide binding]; other site 43989012361 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 43989012362 PYR/PP interface [polypeptide binding]; other site 43989012363 dimer interface [polypeptide binding]; other site 43989012364 TPP binding site [chemical binding]; other site 43989012365 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 43989012366 TPR repeat; Region: TPR_11; pfam13414 43989012367 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 43989012368 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 43989012369 putative ligand binding site [chemical binding]; other site 43989012370 Uncharacterized conserved protein [Function unknown]; Region: COG3349 43989012371 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 43989012372 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989012373 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 43989012374 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989012375 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989012376 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 43989012377 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 43989012378 active site 43989012379 dimer interface [polypeptide binding]; other site 43989012380 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 43989012381 recombinase A; Provisional; Region: recA; PRK09354 43989012382 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 43989012383 hexamer interface [polypeptide binding]; other site 43989012384 Walker A motif; other site 43989012385 ATP binding site [chemical binding]; other site 43989012386 Walker B motif; other site 43989012387 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 43989012388 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 43989012389 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 43989012390 catalytic triad [active] 43989012391 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 43989012392 active site 43989012393 dimer interface [polypeptide binding]; other site 43989012394 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 43989012395 dimer interface [polypeptide binding]; other site 43989012396 active site 43989012397 Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar3; cd08577 43989012398 putative active site [active] 43989012399 catalytic site [active] 43989012400 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 43989012401 Protein export membrane protein; Region: SecD_SecF; pfam02355 43989012402 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 43989012403 protein-export membrane protein SecD; Region: secD; TIGR01129 43989012404 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 43989012405 pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144 43989012406 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 43989012407 alpha subunit interface [polypeptide binding]; other site 43989012408 TPP binding site [chemical binding]; other site 43989012409 heterodimer interface [polypeptide binding]; other site 43989012410 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 43989012411 PRC-barrel domain; Region: PRC; pfam05239 43989012412 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861 43989012413 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 43989012414 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 43989012415 phosphopeptide binding site; other site 43989012416 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 43989012417 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 43989012418 metal binding site [ion binding]; metal-binding site 43989012419 active site 43989012420 I-site; other site 43989012421 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 43989012422 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 43989012423 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 43989012424 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 43989012425 phosphopeptide binding site; other site 43989012426 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 43989012427 metal binding site [ion binding]; metal-binding site 43989012428 active site 43989012429 I-site; other site 43989012430 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 43989012431 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 43989012432 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 43989012433 Caspase domain; Region: Peptidase_C14; pfam00656 43989012434 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 43989012435 ATP-sulfurylase; Region: ATPS; cd00517 43989012436 active site 43989012437 HXXH motif; other site 43989012438 flexible loop; other site 43989012439 Response regulator receiver domain; Region: Response_reg; pfam00072 43989012440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989012441 active site 43989012442 phosphorylation site [posttranslational modification] 43989012443 intermolecular recognition site; other site 43989012444 dimerization interface [polypeptide binding]; other site 43989012445 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989012446 Response regulator receiver domain; Region: Response_reg; pfam00072 43989012447 active site 43989012448 phosphorylation site [posttranslational modification] 43989012449 intermolecular recognition site; other site 43989012450 dimerization interface [polypeptide binding]; other site 43989012451 PAS domain; Region: PAS_9; pfam13426 43989012452 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 43989012453 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989012454 putative active site [active] 43989012455 Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035 43989012456 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 43989012457 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 43989012458 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 43989012459 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 43989012460 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 43989012461 putative active site [active] 43989012462 putative NTP binding site [chemical binding]; other site 43989012463 putative nucleic acid binding site [nucleotide binding]; other site 43989012464 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 43989012465 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 43989012466 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 43989012467 active site 43989012468 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 43989012469 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 43989012470 prephenate dehydratase; Provisional; Region: PRK11898 43989012471 Prephenate dehydratase; Region: PDT; pfam00800 43989012472 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 43989012473 putative L-Phe binding site [chemical binding]; other site 43989012474 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 43989012475 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 43989012476 putative dimer interface [polypeptide binding]; other site 43989012477 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 43989012478 Bacterial SH3 domain; Region: SH3_3; pfam08239 43989012479 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 43989012480 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 43989012481 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 43989012482 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 43989012483 Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158 43989012484 putative homodimer interface [polypeptide binding]; other site 43989012485 putative homotetramer interface [polypeptide binding]; other site 43989012486 putative metal binding site [ion binding]; other site 43989012487 putative homodimer-homodimer interface [polypeptide binding]; other site 43989012488 putative allosteric switch controlling residues; other site 43989012489 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 43989012490 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 43989012491 active site 43989012492 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 43989012493 homopentamer interface [polypeptide binding]; other site 43989012494 active site 43989012495 photosystem II reaction center protein Z; Provisional; Region: psbZ; PRK02576 43989012496 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 43989012497 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 43989012498 active site 43989012499 substrate binding site [chemical binding]; other site 43989012500 metal binding site [ion binding]; metal-binding site 43989012501 mechanosensitive channel MscS; Provisional; Region: PRK10334 43989012502 Mechanosensitive ion channel; Region: MS_channel; pfam00924 43989012503 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 43989012504 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989012505 S-adenosylmethionine binding site [chemical binding]; other site 43989012506 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 43989012507 thiS-thiF/thiG interaction site; other site 43989012508 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 43989012509 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 43989012510 thiamine phosphate binding site [chemical binding]; other site 43989012511 active site 43989012512 pyrophosphate binding site [ion binding]; other site 43989012513 transaldolase/EF-hand domain-containing protein; Provisional; Region: PRK12309 43989012514 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 43989012515 active site 43989012516 dimer interface [polypeptide binding]; other site 43989012517 catalytic residue [active] 43989012518 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 43989012519 Ca2+ binding site [ion binding]; other site 43989012520 phosphoenolpyruvate synthase; Validated; Region: PRK06464 43989012521 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 43989012522 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 43989012523 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 43989012524 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 43989012525 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 43989012526 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 43989012527 GUN4-like; Region: GUN4; pfam05419 43989012528 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 43989012529 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 43989012530 HlyD family secretion protein; Region: HlyD_3; pfam13437 43989012531 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 43989012532 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 43989012533 putative dimer interface [polypeptide binding]; other site 43989012534 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 43989012535 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 43989012536 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 43989012537 C-terminal domain interface [polypeptide binding]; other site 43989012538 GSH binding site (G-site) [chemical binding]; other site 43989012539 dimer interface [polypeptide binding]; other site 43989012540 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 43989012541 putative dimer interface [polypeptide binding]; other site 43989012542 N-terminal domain interface [polypeptide binding]; other site 43989012543 active site 43989012544 FeoA domain; Region: FeoA; pfam04023 43989012545 YwiC-like protein; Region: YwiC; pfam14256 43989012546 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 43989012547 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 43989012548 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 43989012549 Ligand Binding Site [chemical binding]; other site 43989012550 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 43989012551 Ligand Binding Site [chemical binding]; other site 43989012552 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 43989012553 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 43989012554 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 43989012555 ligand binding site [chemical binding]; other site 43989012556 Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154 43989012557 Rab subfamily motif 1 (RabSF1); other site 43989012558 G1 box; other site 43989012559 GTP/Mg2+ binding site [chemical binding]; other site 43989012560 Rab subfamily motif 2 (RabSF2); other site 43989012561 Switch I region; other site 43989012562 G2 box; other site 43989012563 effector interaction site; other site 43989012564 GDI interaction site; other site 43989012565 Rab family motif 1 (RabF1); other site 43989012566 GEF interaction site [polypeptide binding]; other site 43989012567 Rab family motif 2 (RabF2); other site 43989012568 G3 box; other site 43989012569 Switch II region; other site 43989012570 Rab family motif 3 (RabF3); other site 43989012571 Rab family motif 4 (RabF4); other site 43989012572 Rab family motif 5 (RabF5); other site 43989012573 Rab subfamily motif 3 (RabSF3); other site 43989012574 G4 box; other site 43989012575 G5 box; other site 43989012576 Rab subfamily motif 4 (RabSF4); other site 43989012577 Protein of unknown function (DUF904); Region: DUF904; cl11531 43989012578 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 43989012579 PAS fold; Region: PAS_3; pfam08447 43989012580 putative active site [active] 43989012581 heme pocket [chemical binding]; other site 43989012582 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 43989012583 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 43989012584 metal binding site [ion binding]; metal-binding site 43989012585 active site 43989012586 I-site; other site 43989012587 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 43989012588 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 43989012589 pseudouridine synthase; Region: TIGR00093 43989012590 active site 43989012591 DDE superfamily endonuclease; Region: DDE_3; pfam13358 43989012592 Winged helix-turn helix; Region: HTH_29; pfam13551 43989012593 Winged helix-turn helix; Region: HTH_33; pfam13592 43989012594 Response regulator receiver domain; Region: Response_reg; pfam00072 43989012595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989012596 active site 43989012597 phosphorylation site [posttranslational modification] 43989012598 intermolecular recognition site; other site 43989012599 dimerization interface [polypeptide binding]; other site 43989012600 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 43989012601 tetramer interface [polypeptide binding]; other site 43989012602 dimer interface [polypeptide binding]; other site 43989012603 circadian clock protein KaiC; Reviewed; Region: PRK09302 43989012604 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 43989012605 Walker A motif; other site 43989012606 ATP binding site [chemical binding]; other site 43989012607 Walker B motif; other site 43989012608 recA bacterial DNA recombination protein; Region: RecA; cl17211 43989012609 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 43989012610 Walker A motif; other site 43989012611 ATP binding site [chemical binding]; other site 43989012612 Walker B motif; other site 43989012613 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 43989012614 NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415 43989012615 GTP-binding protein LepA; Provisional; Region: PRK05433 43989012616 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 43989012617 G1 box; other site 43989012618 putative GEF interaction site [polypeptide binding]; other site 43989012619 GTP/Mg2+ binding site [chemical binding]; other site 43989012620 Switch I region; other site 43989012621 G2 box; other site 43989012622 G3 box; other site 43989012623 Switch II region; other site 43989012624 G4 box; other site 43989012625 G5 box; other site 43989012626 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 43989012627 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 43989012628 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 43989012629 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 43989012630 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 43989012631 DNA binding residues [nucleotide binding] 43989012632 dimerization interface [polypeptide binding]; other site 43989012633 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 43989012634 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 43989012635 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 43989012636 Domain of unknown function DUF20; Region: UPF0118; pfam01594 43989012637 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 43989012638 DNA polymerase III subunit alpha; Reviewed; Region: PRK07373 43989012639 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 43989012640 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 43989012641 generic binding surface I; other site 43989012642 generic binding surface II; other site 43989012643 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 43989012644 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 43989012645 Probable Catalytic site; other site 43989012646 metal-binding site 43989012647 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 43989012648 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 43989012649 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 43989012650 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 43989012651 Predicted transcriptional regulators [Transcription]; Region: COG1725 43989012652 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 43989012653 DNA-binding site [nucleotide binding]; DNA binding site 43989012654 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 43989012655 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 43989012656 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 43989012657 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 43989012658 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 43989012659 cyclase homology domain; Region: CHD; cd07302 43989012660 nucleotidyl binding site; other site 43989012661 metal binding site [ion binding]; metal-binding site 43989012662 dimer interface [polypeptide binding]; other site 43989012663 Protein of unknown function (DUF2605); Region: DUF2605; pfam10792 43989012664 Protein of unknown function (DUF2973); Region: DUF2973; pfam11189 43989012665 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 43989012666 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 43989012667 active site 43989012668 metal binding site [ion binding]; metal-binding site 43989012669 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 43989012670 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 43989012671 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 43989012672 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 43989012673 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 43989012674 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 43989012675 Permease; Region: Permease; cl00510 43989012676 Protein of unknown function (DUF3122); Region: DUF3122; pfam11320 43989012677 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 43989012678 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 43989012679 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 43989012680 putative NAD(P) binding site [chemical binding]; other site 43989012681 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 43989012682 Double zinc ribbon; Region: DZR; pfam12773 43989012683 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 43989012684 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 43989012685 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 43989012686 phosphopeptide binding site; other site 43989012687 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 43989012688 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 43989012689 putative active site [active] 43989012690 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 43989012691 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 43989012692 cofactor binding site; other site 43989012693 DNA binding site [nucleotide binding] 43989012694 substrate interaction site [chemical binding]; other site 43989012695 HindVP restriction endonuclease; Region: RE_HindVP; pfam09519 43989012696 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 43989012697 DXD motif; other site 43989012698 Predicted membrane protein [Function unknown]; Region: COG2324 43989012699 RDD family; Region: RDD; pfam06271 43989012700 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 43989012701 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 43989012702 putative active site cavity [active] 43989012703 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 43989012704 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 43989012705 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 43989012706 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 43989012707 dimer interface [polypeptide binding]; other site 43989012708 phosphorylation site [posttranslational modification] 43989012709 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989012710 ATP binding site [chemical binding]; other site 43989012711 Mg2+ binding site [ion binding]; other site 43989012712 G-X-G motif; other site 43989012713 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 43989012714 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989012715 active site 43989012716 phosphorylation site [posttranslational modification] 43989012717 intermolecular recognition site; other site 43989012718 dimerization interface [polypeptide binding]; other site 43989012719 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 43989012720 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 43989012721 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 43989012722 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 43989012723 Protein of unknown function (DUF497); Region: DUF497; cl01108 43989012724 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989012725 putative active site [active] 43989012726 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 43989012727 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 43989012728 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 43989012729 homotrimer interface [polypeptide binding]; other site 43989012730 Walker A motif; other site 43989012731 GTP binding site [chemical binding]; other site 43989012732 Walker B motif; other site 43989012733 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 43989012734 AMP binding site [chemical binding]; other site 43989012735 fructose-1,6-bisphosphatase family protein; Region: PLN02628 43989012736 metal binding site [ion binding]; metal-binding site 43989012737 active site 43989012738 Uncharacterized family of heme peroxidases, mostly bacterial; Region: peroxinectin_like_bacterial; cd09822 43989012739 putative heme binding site [chemical binding]; other site 43989012740 putative substrate binding site [chemical binding]; other site 43989012741 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619 43989012742 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 43989012743 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 43989012744 Major Facilitator Superfamily; Region: MFS_1; pfam07690 43989012745 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 43989012746 putative substrate translocation pore; other site 43989012747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 43989012748 Domain of unknown function DUF77; Region: DUF77; pfam01910 43989012749 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 43989012750 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 43989012751 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 43989012752 putative active site [active] 43989012753 putative NTP binding site [chemical binding]; other site 43989012754 putative nucleic acid binding site [nucleotide binding]; other site 43989012755 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 43989012756 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 43989012757 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 43989012758 active site 43989012759 cce_RNA056; group II catalytic intron domains V and VI; Rfam score 42.79 43989012760 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 43989012761 PGAP1-like protein; Region: PGAP1; pfam07819 43989012762 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 43989012763 Domain of unknown function (DUF955); Region: DUF955; pfam06114 43989012764 KTSC domain; Region: KTSC; pfam13619 43989012765 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 43989012766 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 43989012767 active site 43989012768 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 43989012769 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 43989012770 DnaJ domain; Region: DnaJ; pfam00226 43989012771 HSP70 interaction site [polypeptide binding]; other site 43989012772 potential frameshift: common BLAST hit: gi|218442614|ref|YP_002380934.1| P4 family phage/plasmid primase 43989012773 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 43989012774 active site 43989012775 metal binding site [ion binding]; metal-binding site 43989012776 interdomain interaction site; other site 43989012777 D5 N terminal like; Region: D5_N; pfam08706 43989012778 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 43989012779 metal ion-dependent adhesion site (MIDAS); other site 43989012780 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 43989012781 non-specific DNA binding site [nucleotide binding]; other site 43989012782 salt bridge; other site 43989012783 sequence-specific DNA binding site [nucleotide binding]; other site 43989012784 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 43989012785 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 43989012786 Transposase [DNA replication, recombination, and repair]; Region: COG5433 43989012787 Transposase [DNA replication, recombination, and repair]; Region: COG5433 43989012788 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 43989012789 HSP70 interaction site [polypeptide binding]; other site 43989012790 helicase superfamily c-terminal domain; Region: HELICc; smart00490 43989012791 ATP-binding site [chemical binding]; other site 43989012792 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 43989012793 DDE superfamily endonuclease; Region: DDE_5; cl17874 43989012794 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 43989012795 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 43989012796 active site 43989012797 catalytic residues [active] 43989012798 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989012799 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 43989012800 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 43989012801 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989012802 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989012803 CHAT domain; Region: CHAT; cl17868 43989012804 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 43989012805 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 43989012806 AAA ATPase domain; Region: AAA_16; pfam13191 43989012807 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 43989012808 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 43989012809 structural tetrad; other site 43989012810 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 43989012811 FOG: WD40 repeat [General function prediction only]; Region: COG2319 43989012812 structural tetrad; other site 43989012813 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 43989012814 structural tetrad; other site 43989012815 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 43989012816 structural tetrad; other site 43989012817 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 43989012818 active site 43989012819 metal binding site [ion binding]; metal-binding site 43989012820 interdomain interaction site; other site 43989012821 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 43989012822 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 43989012823 active site 43989012824 metal binding site [ion binding]; metal-binding site 43989012825 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 43989012826 domain I; other site 43989012827 phosphate binding site [ion binding]; other site 43989012828 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 43989012829 domain II; other site 43989012830 domain III; other site 43989012831 nucleotide binding site [chemical binding]; other site 43989012832 DNA binding groove [nucleotide binding] 43989012833 catalytic site [active] 43989012834 domain IV; other site 43989012835 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 43989012836 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 43989012837 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 43989012838 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 43989012839 Subunit I/III interface [polypeptide binding]; other site 43989012840 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 43989012841 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 43989012842 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 43989012843 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 43989012844 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 43989012845 Predicted membrane protein [Function unknown]; Region: COG4244 43989012846 Predicted membrane protein [Function unknown]; Region: COG4244 43989012847 Family description; Region: VCBS; pfam13517 43989012848 Family description; Region: VCBS; pfam13517 43989012849 Family description; Region: VCBS; pfam13517 43989012850 Family description; Region: VCBS; pfam13517 43989012851 Family description; Region: VCBS; pfam13517 43989012852 Family description; Region: VCBS; pfam13517 43989012853 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 43989012854 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 43989012855 THF binding site; other site 43989012856 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 43989012857 substrate binding site [chemical binding]; other site 43989012858 THF binding site; other site 43989012859 zinc-binding site [ion binding]; other site 43989012860 S-layer homology domain; Region: SLH; pfam00395 43989012861 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 43989012862 High-affinity nickel-transport protein; Region: NicO; cl00964 43989012863 light-harvesting-like protein 3; Provisional; Region: PLN00014 43989012864 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 43989012865 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 43989012866 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 43989012867 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 43989012868 active site 43989012869 catalytic site [active] 43989012870 substrate binding site [chemical binding]; other site 43989012871 Phylum Aquificae Pol A is different from Escherichia coli Pol A by three signature sequences; Region: DNA_pol_A_Aquificae_like; cd08639 43989012872 active site 43989012873 DNA binding site [nucleotide binding] 43989012874 catalytic site [active] 43989012875 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 43989012876 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 43989012877 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 43989012878 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 43989012879 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 43989012880 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 43989012881 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 43989012882 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 43989012883 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 43989012884 active site 43989012885 dimer interface [polypeptide binding]; other site 43989012886 motif 1; other site 43989012887 motif 2; other site 43989012888 motif 3; other site 43989012889 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 43989012890 anticodon binding site; other site 43989012891 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989012892 putative active site [active] 43989012893 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 43989012894 MPT binding site; other site 43989012895 trimer interface [polypeptide binding]; other site 43989012896 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 43989012897 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 43989012898 active site 43989012899 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 43989012900 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 43989012901 active site 43989012902 HIGH motif; other site 43989012903 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 43989012904 KMSKS motif; other site 43989012905 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 43989012906 tRNA binding surface [nucleotide binding]; other site 43989012907 anticodon binding site; other site 43989012908 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 43989012909 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 43989012910 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 43989012911 PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595 43989012912 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 43989012913 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 43989012914 G1 box; other site 43989012915 GTP/Mg2+ binding site [chemical binding]; other site 43989012916 G2 box; other site 43989012917 Switch I region; other site 43989012918 G3 box; other site 43989012919 Switch II region; other site 43989012920 G4 box; other site 43989012921 G5 box; other site 43989012922 Nucleoside recognition; Region: Gate; pfam07670 43989012923 Nucleoside recognition; Region: Gate; pfam07670 43989012924 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 43989012925 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 43989012926 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 43989012927 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 43989012928 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 43989012929 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 43989012930 metal binding site [ion binding]; metal-binding site 43989012931 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 43989012932 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 43989012933 active site 43989012934 metal binding site [ion binding]; metal-binding site 43989012935 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 43989012936 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 43989012937 dimer interface [polypeptide binding]; other site 43989012938 active site 43989012939 aspartate-rich active site metal binding site; other site 43989012940 allosteric magnesium binding site [ion binding]; other site 43989012941 Schiff base residues; other site 43989012942 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 43989012943 dimerization interface [polypeptide binding]; other site 43989012944 putative DNA binding site [nucleotide binding]; other site 43989012945 putative Zn2+ binding site [ion binding]; other site 43989012946 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 43989012947 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 43989012948 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 43989012949 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 43989012950 P-loop, Walker A motif; other site 43989012951 Base recognition motif; other site 43989012952 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 43989012953 FOG: WD40 repeat [General function prediction only]; Region: COG2319 43989012954 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 43989012955 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 43989012956 structural tetrad; other site 43989012957 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 43989012958 metal binding site 2 [ion binding]; metal-binding site 43989012959 putative DNA binding helix; other site 43989012960 metal binding site 1 [ion binding]; metal-binding site 43989012961 dimer interface [polypeptide binding]; other site 43989012962 structural Zn2+ binding site [ion binding]; other site 43989012963 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 43989012964 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 43989012965 dimer interface [polypeptide binding]; other site 43989012966 putative PBP binding regions; other site 43989012967 ABC-ATPase subunit interface; other site 43989012968 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 43989012969 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 43989012970 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 43989012971 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 43989012972 intersubunit interface [polypeptide binding]; other site 43989012973 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 43989012974 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 43989012975 Src Homology 3 domain superfamily; Region: SH3; cl17036 43989012976 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 43989012977 S-adenosylmethionine binding site [chemical binding]; other site 43989012978 P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872 43989012979 Helicase_C-like; Region: Helicase_C_4; pfam13871 43989012980 DNA polymerase III subunit beta; Validated; Region: PRK05643 43989012981 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 43989012982 putative DNA binding surface [nucleotide binding]; other site 43989012983 dimer interface [polypeptide binding]; other site 43989012984 beta-clamp/clamp loader binding surface; other site 43989012985 beta-clamp/translesion DNA polymerase binding surface; other site 43989012986 PIN domain; Region: PIN_3; pfam13470 43989012987 Helix-turn-helix domain; Region: HTH_17; cl17695 43989012988 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 43989012989 dimer interface [polypeptide binding]; other site 43989012990 putative radical transfer pathway; other site 43989012991 diiron center [ion binding]; other site 43989012992 tyrosyl radical; other site 43989012993 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 43989012994 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 43989012995 P-loop; other site 43989012996 Magnesium ion binding site [ion binding]; other site 43989012997 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 43989012998 ParB-like nuclease domain; Region: ParB; smart00470 43989012999 Domain of unknown function DUF77; Region: DUF77; pfam01910 43989013000 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 43989013001 PGAP1-like protein; Region: PGAP1; pfam07819 43989013002 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 43989013003 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 43989013004 putative acyl-acceptor binding pocket; other site 43989013005 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 43989013006 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 43989013007 putative NAD(P) binding site [chemical binding]; other site 43989013008 putative substrate binding site [chemical binding]; other site 43989013009 catalytic Zn binding site [ion binding]; other site 43989013010 structural Zn binding site [ion binding]; other site 43989013011 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 43989013012 protochlorophyllide reductase; Region: PLN00015 43989013013 NAD(P) binding site [chemical binding]; other site 43989013014 active site 43989013015 Calcium binding; Region: Calci_bind_CcbP; pfam11535 43989013016 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 43989013017 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 43989013018 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 43989013019 classical (c) SDRs; Region: SDR_c; cd05233 43989013020 NAD(P) binding site [chemical binding]; other site 43989013021 active site 43989013022 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 43989013023 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 43989013024 cobalamin binding residues [chemical binding]; other site 43989013025 putative BtuC binding residues; other site 43989013026 dimer interface [polypeptide binding]; other site 43989013027 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 43989013028 EamA-like transporter family; Region: EamA; pfam00892 43989013029 Inward rectifier potassium channel; Region: IRK; pfam01007 43989013030 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 43989013031 Pox virus Ag35 surface protein; Region: Pox_Ag35; cl17789 43989013032 Uncharacterized conserved protein [Function unknown]; Region: COG0397 43989013033 hypothetical protein; Validated; Region: PRK00029 43989013034 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 43989013035 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 43989013036 dimer interface [polypeptide binding]; other site 43989013037 PYR/PP interface [polypeptide binding]; other site 43989013038 TPP binding site [chemical binding]; other site 43989013039 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 43989013040 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 43989013041 TPP-binding site [chemical binding]; other site 43989013042 dimer interface [polypeptide binding]; other site 43989013043 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 43989013044 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 43989013045 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 43989013046 putative active site [active] 43989013047 PhoH-like protein; Region: PhoH; pfam02562 43989013048 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 43989013049 DDE superfamily endonuclease; Region: DDE_5; cl17874 43989013050 Competence protein CoiA-like family; Region: CoiA; cl11541 43989013051 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 43989013052 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 43989013053 active site 43989013054 DNA binding site [nucleotide binding] 43989013055 Int/Topo IB signature motif; other site 43989013056 PemK-like protein; Region: PemK; pfam02452 43989013057 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989013058 putative active site [active] 43989013059 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 43989013060 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 43989013061 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 43989013062 CHASE2 domain; Region: CHASE2; pfam05226 43989013063 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989013064 ATP binding site [chemical binding]; other site 43989013065 Mg2+ binding site [ion binding]; other site 43989013066 G-X-G motif; other site 43989013067 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 43989013068 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989013069 binding surface 43989013070 TPR motif; other site 43989013071 Tetratricopeptide repeat; Region: TPR_12; pfam13424 43989013072 CHAT domain; Region: CHAT; cl17868 43989013073 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 43989013074 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 43989013075 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 43989013076 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 43989013077 Surface antigen; Region: Bac_surface_Ag; pfam01103 43989013078 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 43989013079 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 43989013080 active site 43989013081 phosphorylation site [posttranslational modification] 43989013082 intermolecular recognition site; other site 43989013083 dimerization interface [polypeptide binding]; other site 43989013084 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 43989013085 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 43989013086 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 43989013087 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 43989013088 putative metal binding site [ion binding]; other site 43989013089 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 43989013090 ATP binding site [chemical binding]; other site 43989013091 Mg2+ binding site [ion binding]; other site 43989013092 G-X-G motif; other site 43989013093 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 43989013094 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 43989013095 Walker A motif; other site 43989013096 ATP binding site [chemical binding]; other site 43989013097 Walker B motif; other site 43989013098 arginine finger; other site 43989013099 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 43989013100 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 43989013101 TPR repeat; Region: TPR_11; pfam13414 43989013102 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 43989013103 binding surface 43989013104 TPR motif; other site 43989013105 Protein of unknown function (DUF497); Region: DUF497; pfam04365 43989013106 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 43989013107 RNA/DNA hybrid binding site [nucleotide binding]; other site 43989013108 active site 43989013109 Protein of unknown function (DUF1036); Region: DUF1036; cl02296 43989013110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304 43989013111 Protein of unknown function (DUF497); Region: DUF497; pfam04365 43989013112 Protein of unknown function (DUF433); Region: DUF433; cl01030 43989013113 anthranilate synthase component I; Provisional; Region: PRK13564 43989013114 L-aspartate dehydrogenase; Provisional; Region: PRK13303 43989013115 RNA dependent RNA polymerase; Region: RdRP; pfam05183 43989013116 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 43989013117 Mg binding site [ion binding]; other site 43989013118 nucleotide binding site [chemical binding]; other site 43989013119 putative protofilament interface [polypeptide binding]; other site 43989013120 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 43989013121 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 43989013122 siroheme synthase; Provisional; Region: cysG; PRK10637 43989013123 Domain of unknown function DUF87; Region: DUF87; pfam01935 43989013124 AAA-like domain; Region: AAA_10; pfam12846 43989013125 conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729 43989013126 AAA-like domain; Region: AAA_10; pfam12846 43989013127 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 43989013128 CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158 43989013129 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 43989013130 ATP binding site [chemical binding]; other site 43989013131 putative Mg++ binding site [ion binding]; other site 43989013132 helicase superfamily c-terminal domain; Region: HELICc; smart00490 43989013133 ATP-binding site [chemical binding]; other site 43989013134 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 43989013135 Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683 43989013136 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 43989013137 putative active site [active] 43989013138 homotetrameric interface [polypeptide binding]; other site 43989013139 metal binding site [ion binding]; metal-binding site 43989013140 PemK-like protein; Region: PemK; pfam02452 43989013141 Transposase IS200 like; Region: Y1_Tnp; cl00848 43989013142 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 43989013143 DEAD-like helicases superfamily; Region: DEXDc; smart00487 43989013144 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 43989013145 ATP binding site [chemical binding]; other site 43989013146 putative Mg++ binding site [ion binding]; other site 43989013147 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 43989013148 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 43989013149 nucleotide binding region [chemical binding]; other site 43989013150 ATP-binding site [chemical binding]; other site 43989013151 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 43989013152 Mg binding site [ion binding]; other site 43989013153 nucleotide binding site [chemical binding]; other site 43989013154 putative protofilament interface [polypeptide binding]; other site 43989013155 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 43989013156 AAA domain; Region: AAA_30; pfam13604 43989013157 CHAT domain; Region: CHAT; pfam12770 43989013158 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 43989013159 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 43989013160 ATP binding site [chemical binding]; other site 43989013161 putative Mg++ binding site [ion binding]; other site 43989013162 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 43989013163 nucleotide binding region [chemical binding]; other site 43989013164 ATP-binding site [chemical binding]; other site 43989013165 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 43989013166 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 43989013167 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 43989013168 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 43989013169 Peptidase family M23; Region: Peptidase_M23; pfam01551 43989013170 AAA-like domain; Region: AAA_10; pfam12846 43989013171 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 43989013172 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 43989013173 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 43989013174 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 43989013175 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 43989013176 motif II; other site 43989013177 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 43989013178 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 43989013179 P-loop; other site 43989013180 Magnesium ion binding site [ion binding]; other site 43989013181 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 43989013182 Magnesium ion binding site [ion binding]; other site 43989013183 ParB-like nuclease domain; Region: ParB; smart00470 43989013184 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 43989013185 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 43989013186 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 43989013187 generic binding surface II; other site 43989013188 generic binding surface I; other site 43989013189 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 43989013190 Coenzyme A binding pocket [chemical binding]; other site 43989013191 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 43989013192 HicB family; Region: HicB; pfam05534 43989013193 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 43989013194 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 43989013195 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 43989013196 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 43989013197 non-specific DNA binding site [nucleotide binding]; other site 43989013198 salt bridge; other site 43989013199 sequence-specific DNA binding site [nucleotide binding]; other site 43989013200 CHASE2 domain; Region: CHASE2; pfam05226 43989013201 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 43989013202 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 43989013203 binding surface 43989013204 TPR motif; other site 43989013205 CHAT domain; Region: CHAT; cl17868 43989013206 Domain of unknown function (DUF3598); Region: DUF3598; pfam12204 43989013207 haemagglutination activity domain; Region: Haemagg_act; pfam05860 43989013208 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 43989013209 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 43989013210 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 43989013211 Surface antigen; Region: Bac_surface_Ag; pfam01103 43989013212 CARDB; Region: CARDB; pfam07705 43989013213 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 43989013214 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 43989013215 RNB domain; Region: RNB; pfam00773 43989013216 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 43989013217 dsRNA binding site [nucleotide binding]; other site 43989013218 RRXRR protein; Region: RRXRR; pfam14239 43989013219 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 43989013220 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 43989013221 active site 43989013222 RNB domain; Region: RNB; pfam00773 43989013223 PIN domain; Region: PIN_3; cl17397 43989013224 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 43989013225 IHF dimer interface [polypeptide binding]; other site 43989013226 IHF - DNA interface [nucleotide binding]; other site 43989013227 hypothetical protein; Reviewed; Region: PRK12275 43989013228 four helix bundle protein; Region: TIGR02436 43989013229 Calcium binding; Region: Calci_bind_CcbP; pfam11535 43989013230 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 43989013231 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 43989013232 Transposase domain (DUF772); Region: DUF772; pfam05598 43989013233 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 43989013234 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 43989013235 Catalytic site [active] 43989013236 DDE superfamily endonuclease; Region: DDE_3; pfam13358 43989013237 Homeodomain-like domain; Region: HTH_23; pfam13384 43989013238 Winged helix-turn helix; Region: HTH_29; pfam13551 43989013239 Homeodomain-like domain; Region: HTH_32; pfam13565 43989013240 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 43989013241 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 43989013242 NAD(P) binding site [chemical binding]; other site 43989013243 active site 43989013244 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 43989013245 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 43989013246 NAD(P) binding site [chemical binding]; other site 43989013247 active site 43989013248 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 43989013249 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 43989013250 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 43989013251 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 43989013252 Exocyst complex component Sec6; Region: Sec6; pfam06046 43989013253 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 43989013254 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 43989013255 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 43989013256 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 43989013257 putative active site [active] 43989013258 Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451 43989013259 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 43989013260 Walker A/P-loop; other site 43989013261 ATP binding site [chemical binding]; other site 43989013262 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 43989013263 Walker B; other site 43989013264 D-loop; other site 43989013265 H-loop/switch region; other site 43989013266 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 43989013267 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989013268 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989013269 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 43989013270 T5orf172 domain; Region: T5orf172; cl17462 43989013271 Competence protein CoiA-like family; Region: CoiA; cl11541 43989013272 potential frameshift: common BLAST hit: gi|172055297|ref|YP_001806624.1| putative RuvC-like Holliday junction resolvase 43989013273 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 43989013274 UbiA prenyltransferase family; Region: UbiA; pfam01040 43989013275 Protein of unknown function DUF262; Region: DUF262; pfam03235 43989013276 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 43989013277 HD domain; Region: HD_4; pfam13328 43989013278 DDE superfamily endonuclease; Region: DDE_4; pfam13359 43989013279 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 43989013280 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 43989013281 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 43989013282 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 43989013283 catalytic residues [active] 43989013284 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 43989013285 NADH(P)-binding; Region: NAD_binding_10; pfam13460 43989013286 NAD(P) binding site [chemical binding]; other site 43989013287 putative active site [active] 43989013288 GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441 43989013289 GIY-YIG motif/motif A; other site 43989013290 putative active site [active] 43989013291 putative metal binding site [ion binding]; other site 43989013292 SnoaL-like domain; Region: SnoaL_3; pfam13474 43989013293 Protein of unknown function (DUF4087); Region: DUF4087; pfam13316 43989013294 DDE superfamily endonuclease; Region: DDE_4; pfam13359 43989013295 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 43989013296 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 43989013297 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 43989013298 Coenzyme A binding pocket [chemical binding]; other site 43989013299 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 43989013300 Staphylococcal nuclease homologues; Region: SNc; smart00318 43989013301 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 43989013302 Catalytic site; other site 43989013303 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 43989013304 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 43989013305 Transposase [DNA replication, recombination, and repair]; Region: COG5433 43989013306 Transposase [DNA replication, recombination, and repair]; Region: COG5433 43989013307 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 43989013308 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 43989013309 AAA-like domain; Region: AAA_10; pfam12846 43989013310 Walker A/P-loop; other site 43989013311 ATP binding site [chemical binding]; other site 43989013312 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 43989013313 Walker B motif; other site 43989013314 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 43989013315 putative active site [active] 43989013316 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 43989013317 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 43989013318 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 43989013319 active site 43989013320 substrate binding site [chemical binding]; other site 43989013321 Mg2+ binding site [ion binding]; other site 43989013322 Lamin Tail Domain; Region: LTD; pfam00932 43989013323 AAA domain; Region: AAA_22; pfam13401 43989013324 AAA domain; Region: AAA_30; pfam13604 43989013325 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 43989013326 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 43989013327 P-loop; other site 43989013328 Magnesium ion binding site [ion binding]; other site 43989013329 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 43989013330 Putative Ig domain; Region: He_PIG; pfam05345 43989013331 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 43989013332 active site 43989013333 DNA binding site [nucleotide binding] 43989013334 Int/Topo IB signature motif; other site 43989013335 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 43989013336 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 43989013337 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 43989013338 DDE superfamily endonuclease; Region: DDE_4; cl17710 43989013339 Protein of unknown function (DUF3997); Region: DUF3997; pfam13162 43989013340 CHAD domain; Region: CHAD; pfam05235 43989013341 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 43989013342 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 43989013343 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 43989013344 ligand binding site [chemical binding]; other site 43989013345 flexible hinge region; other site 43989013346 polyphosphate kinase; Provisional; Region: PRK05443 43989013347 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 43989013348 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 43989013349 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 43989013350 putative domain interface [polypeptide binding]; other site 43989013351 putative active site [active] 43989013352 catalytic site [active] 43989013353 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 43989013354 putative domain interface [polypeptide binding]; other site 43989013355 putative active site [active] 43989013356 catalytic site [active] 43989013357 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 43989013358 catalytic core [active] 43989013359 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 43989013360 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 43989013361 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 43989013362 domain interfaces; other site 43989013363 active site 43989013364 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 43989013365 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 43989013366 active site 43989013367 dimer interface [polypeptide binding]; other site 43989013368 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 43989013369 dimer interface [polypeptide binding]; other site 43989013370 active site 43989013371 enolase; Provisional; Region: eno; PRK00077 43989013372 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 43989013373 dimer interface [polypeptide binding]; other site 43989013374 metal binding site [ion binding]; metal-binding site 43989013375 substrate binding pocket [chemical binding]; other site 43989013376 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 43989013377 von Willebrand factor type A domain; Region: VWA_2; pfam13519 43989013378 metal ion-dependent adhesion site (MIDAS); other site 43989013379 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 43989013380 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 43989013381 ligand binding site [chemical binding]; other site 43989013382 flexible hinge region; other site 43989013383 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 43989013384 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 43989013385 ligand binding site [chemical binding]; other site 43989013386 flexible hinge region; other site 43989013387 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 43989013388 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 43989013389 putative phosphoketolase; Provisional; Region: PRK05261 43989013390 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 43989013391 TPP-binding site; other site 43989013392 XFP C-terminal domain; Region: XFP_C; pfam09363 43989013393 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 43989013394 homodimer interface [polypeptide binding]; other site 43989013395 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 43989013396 active site pocket [active] 43989013397 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 43989013398 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 43989013399 NAD binding site [chemical binding]; other site 43989013400 dimer interface [polypeptide binding]; other site 43989013401 substrate binding site [chemical binding]; other site 43989013402 tetramer (dimer of dimers) interface [polypeptide binding]; other site 43989013403 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 43989013404 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 43989013405 tetrameric interface [polypeptide binding]; other site 43989013406 activator binding site; other site 43989013407 NADP binding site [chemical binding]; other site 43989013408 substrate binding site [chemical binding]; other site 43989013409 catalytic residues [active] 43989013410 phosphate transporter ATP-binding protein; Provisional; Region: PRK14243 43989013411 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 43989013412 Walker A/P-loop; other site 43989013413 ATP binding site [chemical binding]; other site 43989013414 Q-loop/lid; other site 43989013415 ABC transporter signature motif; other site 43989013416 Walker B; other site 43989013417 D-loop; other site 43989013418 H-loop/switch region; other site 43989013419 phosphate transporter ATP-binding protein; Provisional; Region: PRK14243 43989013420 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 43989013421 Walker A/P-loop; other site 43989013422 ATP binding site [chemical binding]; other site 43989013423 Q-loop/lid; other site 43989013424 ABC transporter signature motif; other site 43989013425 Walker B; other site 43989013426 D-loop; other site 43989013427 H-loop/switch region; other site 43989013428 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 43989013429 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 43989013430 Transposase; Region: HTH_Tnp_1; pfam01527 43989013431 HTH-like domain; Region: HTH_21; pfam13276 43989013432 Integrase core domain; Region: rve; pfam00665 43989013433 Integrase core domain; Region: rve_3; pfam13683 43989013434 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 43989013435 TrkA-N domain; Region: TrkA_N; pfam02254 43989013436 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 43989013437 TrkA-N domain; Region: TrkA_N; pfam02254 43989013438 PBP superfamily domain; Region: PBP_like_2; cl17296 43989013439 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 43989013440 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 43989013441 active site 43989013442 metal binding site [ion binding]; metal-binding site 43989013443 FOG: WD40 repeat [General function prediction only]; Region: COG2319 43989013444 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 43989013445 structural tetrad; other site 43989013446 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 43989013447 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 43989013448 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 43989013449 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 43989013450 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 43989013451 motif II; other site 43989013452 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 43989013453 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 43989013454 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 43989013455 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 43989013456 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 43989013457 Soluble P-type ATPase [General function prediction only]; Region: COG4087 43989013458 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 43989013459 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 43989013460 Protein of unknown function (DUF3254); Region: DUF3254; pfam11630 43989013461 Transposase [DNA replication, recombination, and repair]; Region: COG5433 43989013462 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 43989013463 Transposase [DNA replication, recombination, and repair]; Region: COG5433 43989013464 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 43989013465 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 43989013466 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 43989013467 active site 43989013468 putative DNA-binding cleft [nucleotide binding]; other site 43989013469 dimer interface [polypeptide binding]; other site 43989013470 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 43989013471 D5 N terminal like; Region: D5_N; pfam08706 43989013472 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 43989013473 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 43989013474 DNA-binding site [nucleotide binding]; DNA binding site 43989013475 RNA-binding motif; other site 43989013476 Uncharacterized conserved protein [Function unknown]; Region: COG5464 43989013477 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 43989013478 Uncharacterized conserved protein [Function unknown]; Region: COG5464 43989013479 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261